; SAM: prettyalign v3.1b (February 24, 1999) compiled 04/18/00_11:44:15 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ------ Citations (HMMs, SAM) ------ ; A. Krogh et al., Hidden Markov models in computational biology: ; ------------- Citations (SAM, SAM-T99, HMMs) ----------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; -------------------------------------------------------------- ; Sequence numbers correspond to the following labels: ; 1 T0089 ; 2 gi|6715614|gb|AAA95992.2|_1:413 ; 3 gi|2707899|gb|AAB92376.1|_1:388 ; 4 gi|120568|sp|P06137|FTSA_ECOLI_1:412 ; 5 gi|146025|gb|AAA23811.1|_1:412 ; 6 gi|7380686|emb|CAB85276.1|_4:411 ; 7 gi|7225649|gb|AAF40864.1|_4:411 ; 8 gi|4033383|sp|O51928|FTSA_BUCAP_1:414 ; 9 gi|1169751|sp|P45068|FTSA_HAEIN_1:409 ; 10 gi|120567|sp|P28264|FTSA_BACSU_2:373 ; 11 gi|3122114|sp|O30994|FTSA_RHIME_17:416 ; 12 gi|7471223|pir||D75494_1:378 ; 13 gi|7462793|pir||G72328_1:419 ; 14 gi|3122097|sp|O30991|FTSA_AGRTU_17:416 ; 15 gi|7443771|pir||D70347_5:413 ; 16 gi|1200208|emb|CAA78155.1|_3:382 ; 17 gi|3023796|sp|Q44774|FTSA_BORBU_3:382 ; 18 gi|4433657|gb|AAD20834.1|_9:404 ; 19 gi|4009469|gb|AAC95439.1|_2:365 ; 20 gi|7465360|pir||C71873_2:418 ; 21 gi|3122103|sp|O07672|FTSA_ENTHR_2:370 ; 22 gi|3122110|sp|O25629|FTSA_HELPY_2:418 ; 23 gi|5834365|gb|AAD53931.1|AF179611_15_1:407 ; 24 gi|7443772|pir||G71331_3:385 ; 25 gi|6968152|emb|CAB72969.1|_5:390 ; 26 gi|4138103|emb|CAA75615.1|_2:368 ; 27 gi|7467594|pir||G71679_6:409 ; 28 gi|3122101|sp|O07111|FTSA_ENTFA_2:344 ; 29 gi|1230567|gb|AAC05418.1|_5:377 ; 30 gi|729993|sp|P39751|MBL_BACSU_6:316 ; 31 gi|6983753|emb|CAB75392.1|_11:322 ; 32 gi|7444224|pir||E64691_13:329 ; 33 gi|2920363|gb|AAC04558.1|_13:329 ; 34 gi|7444221|pir||E71826_13:329 ; 35 gi|2039364|gb|AAB53051.1|_5:375 ; 36 gi|7444223|pir||E71316_1:321 ; 37 gi|2598562|emb|CAA05361.1|_26:400 ; 38 gi|3122102|sp|O07325|FTSA_STAAU_3:400 ; 39 gi|6470150|gb|AAF13605.1|AF188611_1_7:381 ; 40 gi|7444226|pir||D69660_9:321 ; 41 gi|121570|sp|P07823|GR78_MESAU_25:399 ; 42 gi|2506545|sp|P20029|GR78_MOUSE_26:400 ; 43 gi|109893|pir||A37048_26:400 ; 44 gi|6900104|emb|CAB71335.1|_25:399 ; 45 gi|121574|sp|P06761|GR78_RAT_25:399 ; 46 gi|266568|sp|Q01465|MREB_BACSU_9:321 ; 47 gi|417314|sp|P32444|MBL_BACCE_6:316 ; 48 gi|1945628|emb|CAA72797.1|_5:371 ; 49 gi|1708306|sp|Q10265|HS71_SCHPO_5:374 ; 50 gi|7494626|pir||T34037_26:400 ; 51 gi|730060|sp|P39763|MREH_BACSU_6:319 ; 52 gi|1708633|gb|AAB38076.1|_30:404 ; 53 gi|1929868|gb|AAB58248.1|_32:405 ; 54 gi|6967753|emb|CAB72744.1|_14:328 ; 55 gi|4033392|sp|Q90593|GR78_CHICK_23:397 ; 56 gi|3850199|gb|AAC72002.1|_6:376 ; 57 gi|3850197|gb|AAC72001.1|_6:376 ; 58 gi|3323502|gb|AAC26629.1|_6:376 ; 59 gi|121567|sp|P11021|GR78_HUMAN_25:398 ; 60 gi|3004463|emb|CAA04673.1|_5:376 ; 61 gi|2253079|emb|CAA74597.1|_11:321 ; 62 gi|6322426|ref|NP_012500.1|KAR2_46:419 ; 63 gi|7503381|pir||T22169_7:375 ; 64 gi|3426021|dbj|BAA32395.1|_29:401 ; 65 gi|2827905|gb|AAB99911.1|_7:379 ; 66 gi|2529289|gb|AAB95297.1|_7:379 ; 67 gi|2636166|emb|CAB15658.1|_6:302 ; 68 gi|311895|emb|CAA48873.1|_28:396 ; 69 gi|5805059|emb|CAB53636.1|_3:339 ; 70 gi|1684654|emb|CAB05381.1|_6:298 ; 71 gi|7495875|pir||T19211_6:375 ; 72 gi|7462820|pir||A72273_2:372 ; 73 gi|3122104|sp|O07827|FTSA_PORGI_5:346 ; 74 gi|5738968|dbj|BAA83426.1|_32:340 ; 75 gi|7444225|pir||B70189_16:339 ; 76 gi|4164594|gb|AAD05564.1|_13:262 ; 77 gi|436763|dbj|BAA02189.1|_16:292 ; 78 gi|2921217|gb|AAC05357.1|_34:344 ; 79 gi|1346046|sp|P47203|FTSA_PSEAE_7:230 ; 80 gi|1236795|gb|AAA93010.1|_6:264 ; 81 gi|585273|sp|Q08276|HS7M_SOLTU_56:426 ; 82 gi|3510734|gb|AAC33583.1|_10:362 ; 83 gi|3122010|sp|P94317|DNAK_BRAJA_4:371 ; 84 gi|7579069|gb|AAF64243.1|AF252299_1_3:229 ; 85 gi|300265|gb|AAB26551.1|_20:325 ; 86 gi|2706556|emb|CAA78755.1|_1:220 ; 87 gi|2829291|gb|AAC00520.1|_15:259 ; 88 gi|2253225|gb|AAB62884.1|_3:203 ; 89 gi|1854597|gb|AAB48219.1|_9:215 ; 90 gi|345402|pir||A44261_9:202 ; 91 gi|1854613|gb|AAB48227.1|_9:215 ; 92 gi|295365|gb|AAA30206.1|_10:201 ; 93 gi|7441860|pir||T07620_1:197 ; 94 gi|1854603|gb|AAB48222.1|_9:214 ; 95 gi|1628635|gb|AAB17395.1|_4:216 ; 96 gi|1084481|pir||S48023_1:148 ; 97 gi|1808585|emb|CAA67132.1|_3:158 ; 98 gi|1196309|gb|AAB51401.1|_3:101 ; 99 gi|2661598|emb|CAA15711.1|_18:406 10 20 30 40 | | | | 1 MIDLSKTVFYTSIDIGSRYIKGLVLGK........R..DQEWEALAF.SS........VKSRGLD 2 MASVQSGKMIVGLDIGTSKVVALVGEV........Ta.DGQLEVVGI.GT........HPSRGLK 3 MANAHSGKMIVGLDIGTSKVVALVGEV........Ge.DGTLEIVGI.GT........HPSRGLK 4 MIKATDRKLVVGLEIGTAKVAALVGEV........Lp.DGMVNIIGV.GS........CPSRGMD 5 MIKATDRKLVVGLEIGTAKVAALVGEV........Lp.DGMVNIIGV.GS........CPSRGMD 6 -----QQRYISVLDIGTSKVLALIGEV........Qd.DDKINIVGL.GQ........APSRGLR 7 -----QQRYISVLDIGTSKVLALIGEV........Qd.DDKINIVGL.GQ........APSRGLR 8 MIISKNRKLVVGLEIGTTKVVTLVGEV........Lt.NGKIKIIGI.GI........CQSNGID 9 MVKGVETKTIVGLEVGTSKVVVVVGEV........Fp.DGVVNVLGV.GS........CPSKGID 10 ----NNNELYVSLDLGTSNTKVIVGEM........T..GDSLNIIGV.GN........VPSEGLK 11 -LPSKRSHVVSVLDIGSTKVVCMIGRLtpr11lpgR..THSIEVIGI.GH........QKSRGVK 12 ---MRENSIIVGLDIGTTKITTVIGEV........Ap.DGTIDIIGE.GS........VPSEGMK 13 MIDLSKTVFYTSIDIGSRYIKGLVLGK........R..DQEWEALAF.SS........VKSRGLD 14 -LSSKRSHIVSVLDIGSTKVVCMIGRLtpr11lpgR..THKVEIIGI.GH........QRSRGVK 15 ----------AALDIGSQKTVFVIGER........Ds.YGDIHIIGF.GE........VPSRGIV 16 ------RNLIVGLDVGTSKICTVVAEV........Nl.NDQLEIVGI.GT........SISRGVR 17 ------RNLIVGLDVGTSKICTVVAEV........Nl.NDQLEIVGI.GT........SISRGVR 18 --GWRKTRFLTVLDVGSSKIVCLIACLhpl11lygR..THSIEILGF.GM........QRSCGIK 19 ----AREGFFTGLDIGTSSVKVLVAEQ........R..NGELNVIGV.SN........AKSKGVK 20 ----EHKEIVIGVDIGSRKICAIVAEF........K..DGILRIIGT.AHqdske...INSKAIK 21 ----AKTGMYVGLDIGTTSVKVVVAEY........I..DSQMNIIGV.GN........AKSEGIN 22 ----EHKEIVIGVDLGSRKICAIVAEF........K..EGILRIIGT.AHqdske...INSKAIK 23 MTPVKEGNLITALDIGSSKISALIVEK........Ra.DNVLQVLGS.GQ........RESLGVR 24 -------EVIVGLDIGTESIRAVVAER........Le.GGALQVVGV.GV........GHSKGLR 25 ---------ILGIDLGSTQTCAIIAQK........D..EDGLKIIGF.SK........SKTNGVK 26 ----AKSGLYTGVDIGTNTIKVLVAEY........V..SGEMNIIGV.GN........AKSDGLK 27 -------SNFVTFDFGSSKIAVIAAYI........Sk.KGEIKVASQ.NL........HHSKGIK 28 ---------------------------........-..----NIIGV.GN........AKSDGLN 29 ----------VGIDLGTTYSCVGIFR-........-..DDRIEIIAN.DQgnr20igdAAKNQVA 30 ----------IGIDLGTANVLIHVKGK........GivLNEPSVVAL.DKnsg23gniVAIRPLK 31 ---------DMAVDLGTANTLVYVRGR........GivLNEPSVVAI.NTntg23gniVAVRPLK 32 ---------DIAIDLGTANTIVLVKGQ........GiiINEPSIVAV.RMglf28nsiRAIRPMK 33 ---------DIAIDLGTANTIVLVKGQ........GiiINEPSIVAV.RMglf28nsiRAIRPMK 34 ---------DIAIDLGTANTIVLVKGQ........GiiINEPSIVAV.RMglf28nsiRAIRPMK 35 ----------IGIDLGTTYSCVGIFR-........-..DDRIEIIAN.EQgnr32pqt------- 36 MFFLRRFSADVGIDLGTCNTIIYVEGR........GivVNEPSVVAV.ERgtk23gniVAIRPLK 37 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 38 ------EHYYVSIDIGSSSVKTIVGEK........F..HNGINVIGT.GQ........TYTSGIK 39 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 40 ----------LGIDLGTANTLVFVKGK........GivVREPSVVAL.QTdtk23gnvVALRPMK 41 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 42 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 43 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 44 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 45 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 46 ----------LGIDLGTANTLVFVKGK........GivVREPSVVAL.QTdtk23gnvVALRPMK 47 ----------IGIDLGTANVLIHVKGK........GivLNEPSVVAI.DRntg23gniVAIRPLK 48 ----------IGIDLGTTYSCVAVWQ-........-..QDRVEIIAN.DQgnr25knq-----VA 49 ----------IGIDLGTTYSC--VGHF........S..NNRVEIIAN.DQgnr28vam------- 50 ---EEKMGTIIGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr30lti------- 51 ---------EIGIDLGTANILVYSKNK........GiiLNEPSVVAV.DTttk23gkiVAVRPMK 52 --KEESYGTVIGIDLGTTYSCVGVMQ-........-..SGRVEILAN.DQgnr20vgdAAKNQAP 53 ---EESYGAVIGIDLGTTYSCVGVMQ-........-..SGRVEILPN.DQgnr20vgdAAKNQAP 54 ----------MGIDLGTANTLVLVKDK........GivINEPSVVAV.ERery27gniEAIRPMK 55 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 56 ---------AVGIDLGTTYSCVGVWK-........-..NDAVEIIAN.DQgnr20vgdAAKNQVA 57 ---------AVGIDLGTTYSCVGVWK-........-..NDAVEIIAN.DQgnr20vgdAAKNQVA 58 ---------AVGIDLGTTYSCVGVWK-........-..NDAVEIIAN.DQgnr20vgdAAKNQVA 59 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 60 -------GVAIGIDLGTTYSCVGVFQ-........-..HGKVEIIAN.DQgnr28valNPSNTVF 61 ---------DMAVDLGTANTLVYVRGR........GivLNEPSVVAI.NTntg22rniVAVRPLK 62 ---VENYGTVIGIDLGTTYSCVAVMK-........-..NGKTEILAN.EQgnr20igdAAKNQVA 63 ----------IGIDLGTTYSCVGIYQ-........-..NGKVEILAN.SEgnk28aar------- 64 -----DIGTVIGIDLGTTYSCVGVYK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 65 -------APAIGIDLGTTYSCVGVFQ-........-..HGKVEIIAN.DQgnr28aamNPSNTVY 66 -------APAIGIDLGTTYSCVGVFQ-........-..HGKVEIIAN.DQgnr28aamNPSNTVY 67 ----------IGIDLGTANVLIHVKGK........GivLNEPSVVAL.DKnsg23gniVAIRPLK 68 -------GPVIGIDLGTTYSCVGVFK-........-..NGRVEILNN.ELgnr28atlHPTQTVF 69 ------KEFIVAIELGSSKMTGIAGQK........Nl.DGSISVLSIvEE........DSTSCIR 70 ----------IGIDLGTANVLIHVKGK........GivLNEPSVVAL.DKnsg23gniVAIRPLK 71 ---------AIGIDLGTTYSCVGIYQ-........-..NGKVEILAN.SEgnk28aar------- 72 ---------IFALDVGTRKIAGLIAVE........E..KGTIRIVDS.ELie......HKTRTMF 73 ------NTIYAVIDLGSWYIRGMVARK........Me.DGRVSPISF.YEe.......PANNCIR 74 ---------------------------........-..---------.--........------- 75 ---FKSFLIDIGIDLGTCNTLVYIKDY........GvvMSEPSVVAI.DItkg24eniKAVRPLR 76 ---------------------------........-..---------.--........------- 77 ---------------------------........-..---------.--........------- 78 ---------------------------........-..---------.--........------- 79 ---------------------------........-..---------.--........------- 80 ---------------------------........-..---------.--........------- 81 ------GNEIIGIDLGTTNSCVAVMEGknp11seg-a.RTTPSVVAF.NQkgellvgtPAKRQAV 82 ---------------------------........-..NGKVDIIAN.EAgsr20vgeAAKHQMA 83 ---------VIGIDLGTTNSCVAVMDGkna11segM..RTTPSIVAV.TDdge16avt------- 84 ---------------------------........-..---------.--........------- 85 ---------------------------........-..---------.--........------- 86 ---------------------------........-..---------.--........------- 87 ---------------------------........-..---------.--........------- 88 ---------------------------........-..---------.--........------- 89 ---------------------------........-..---------.--........------- 90 ---------------------------........-..---------.--........------- 91 ---------------------------........-..---------.--........------- 92 ---------------------------........-..---------.--........------- 93 ---------------------------........-..---------.--........------- 94 ---------------------------........-..---------.--........------- 95 ---------------------------........-..---------.--........------- 96 ---------------------------........-..---------.--........------- 97 ---------------------------........-..---------.--........------- 98 ---------------------------........-..---------.--........------- 99 -----QGAAVMSVDLGSEWMKVGVVSP........G..VPME--IAL.NResk35say------- 50 60 70 80 90 | | | | | 1 EGEIKDAIAFKESVNTLLKELEEQL..QKSLRSD........FVISFSSVSFE.....REDTVI. 2 KGVVVNIESTVQSIQRAIDEAQQMA..GCRIHS-........AFVGIAGNHIR.....SLNSHG. 3 KGVVVNIESTVQSIQRAVEEAQLMA..GCRIHS-........AFVGVAGNHIR.....SLNSHG. 4 KGGVNDLESVVKCVQRAIDQAELMA..DCQISS-........VYLALSGKHIS.....CQNEIG. 5 KGGVNDLESVVKCVQRAIDQAELMA..DCQISS-........VYLALSGKHIS.....CQNEIG. 6 AGMVTNIDATVQAIRQAVNDAELMA..DTKITH-........VTTGIAGNHIR.....SLNSQG. 7 AGMVTNIDATVQAIRQAVNDAELMA..DTKITH-........VTTGIAGNHIR.....SLNSQG. 8 KGRINDLDAVISCIRESIHQAEIMA..NCQITS-........VYLSLSSKYIN.....CPNEIG. 9 RGSITDLDAVVGSIQRAIEAAESMA..DCQIMS-........VTLAITGEHIQ.....SLNESG. 10 KGSIVDIDETVHSIRKAFDQAERMV..GFPLRK-........AIVGVNGNYIN.....IQDTNG. 11 NGVIADLDAVESVVRLAVDAAERMA..GLTIDS-........LIVNVSAGRLQ.....SDVYTA. 12 RGSVINLERATQAIKQSLHAAERVS..GVRAWN-........VFVSVGGNHTK.....AMTSHG. 13 EGEIKDAIAFKESVNTLLKELEEQL..QKSLRSD........FVISFSSVSFE.....REDTVI. 14 SGVIADLDALEGVIRLSVDAAERMA..GLTVDS-........LIVNVSAGRLA.....SDIYTA. 15 KGVINDLSEAKGSILRAMKEAEAMA..GLKVRE-........VVYNVSGGTTKngtvkSQNVKD. 16 KGVLINIEAALDSISNSIEAAELIS..GCDITS-........LSVSMSGSSVE.....GTNSRG. 17 KGVLINIEAALDSISNSIEAAELIS..GCDITS-........LSVSMSGSSVE.....GTNSRG. 18 SGVIMDMVAAERSIRLAVDAAEKMA..GLVVDS-........VIVNFSSSCLK.....SSFING. 19 DGIIVDIDAAATAIKSAISQAEEKA..GISIKS-........VNVGLPGNLLQ.....VEPTQG. 20 RGRINSLAHASNAIKEVINSAKKMA..GLNADEDrnn17ktkAIVSFSGAYTE.....SIRDVT. 21 RGIIVDIDKTVQAIQRAVRQAEEKA..GIQIKG-........VSVGLPANLLE.....VENCQG. 22 RGRINSLAHASNAIKEVINSAKKMA..GLNADEDrnn16ktkAIVSFSGAYTE.....SIRDVT. 23 RGYLFDMESTEKAVREAVEQAERIA..GTNIES-........VWVSFSAGGLI.....SDLSST. 24 RGVVVNIENTVVGIHHAVEAAEMMS..GIEVAH-........CVVGLGGTHIE.....GRNLKG. 25 KGAITNIELASKSIEEAVRSAEMMS..GVHYDR-........VVVSISGAYTK.....SVDSIG. 26 NGIIVDIEKVAQALRKAVNAAEERA..GITIDR-........INVSIPANSLE.....MEPCQG. 27 SGVILDLKNAETSILTAIYALEKDC..GKNINK-........IILSLSGAETK.....SYYINY. 28 RGIVVDIDQTVQAIQRAVRQAEEKA..GIQIKS-........VNVGLPANLLE.....VESCQG. 29 MNPANTVFDAKRLIGRKFADPEVQA..DMKHFPF........KIT------DK.....GGKPVI. 30 DGVIADFEVTEAMLKHFINKLNVKG..LFSKPR-........-----------.....-----M. 31 DGVIADFEITERMLRYFILKIHKRR..YLARPR-........-----------.....-----V. 32 DGVIADYDITAKMIRYFIEKVHKRK..TWIRPR-........-----------.....-----I. 33 DGVIADYDITAKMIRYFIEKAHKRK..TWIRPR-........-----------.....-----I. 34 DGVIADYDITAKMIRYFIEKAHKRK..TWIRPR-........-----------.....-----I. 35 ------VFEAKRLIGRKFADPEVQA..DMKHFPF........------KITDK.....GGNPKI. 36 DGVIADMDTTEKMIRYFISKILPRH..RLIKPR-........-----------.....-----M. 37 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 38 NGLIDDFDIARQAIKDTIKKASIAS..GVDIKE-........VFLKLPIIGTE.....VYDESN. 39 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 40 DGVIADYETTATMMKYYINQAIKNK..GMFTRK-........-----------.....---PYV. 41 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 42 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 43 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 44 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 45 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 46 DGVIADYETTATMMKYYINQAIKNK..GMFARK-........-----------.....---PYV. 47 DGVIADFEITEAMLKYFINKLDVKS..FFSKPR-........-----------.....-----I. 48 MNPYNTVFDAKRLIGRKFEDAEVQS..DMKHWPF........KVISRLASLHQ.....VEYARG. 49 -NPHNTIFDAKRLIGRRFNDPEVQS..DMKHWPF........KVIEKDGKP--.....----LI. 50 -NPENTIFDAKRLIGRFYNEKTVQQ..DIKHWPF........KIVD------K.....SNKPNV. 51 DGVIADYDMTTDLLKHIMKKAAKSI..GMSFRK-........-----------.....---PNV. 52 ANPLNTIFDVKRLIGRRFDDVDVQA..DMKHWP-........-----FKVHHQ.....DGKPHV. 53 ANPLNTIFDVKRLIGRRFDEADVQS..DIKNFP-........FKVNHHE----.....-GKPHV. 54 DGVIADFDMTEKMIRYFIEKTHRRK..SFLRPR-........-----------.....-----I. 55 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKYLPF........KV------VEK.....KAKPHI. 56 RNPENTIFDAKRLIGRKFDDPSVQS..DMKHWPF........KVIAGPGD---.....--KPLI. 57 RNPENTIFDAKRLIGRKFDDPSVQS..DMKHWPF........KVIAGPGD---.....--KPLI. 58 RNPENTIFDAKRLIGRKFDDPSVQS..DMKHWPF........KVIAGPGD---.....--KPLI. 59 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 60 --------DAKRLIGRKFDEPVVQA..DMKHWPF........KVISDGGK---.....---PKI. 61 DGVIADFEITERMLRYFILKIHKRR..YLARPR-........-----------.....-----V. 62 ANPQNTIFDIKRLIGLKYNDRSVQK..DIKHLPF........NVVNKDGK---.....---PAV. 63 -NPENTVFDAKRLIGRRFDESTVQS..DCKHWP-........-----FGVKGK.....QGKPVI. 64 TNPENTVFDAKRLIGREWSDQTVQH..DVKFFPF........KV------VEK.....NSKPHV. 65 --------DAKRLIGRKFDDKTVQN..DMKHWPF........KVVEVDGRPK-.....-----I. 66 --------DAKRLIGRKFDDKTVQN..DMKHWPF........KVVEVDGRPK-.....-----I. 67 DGVIADFEVTEAMLKHFINKLNVKG..LFSKPR-........-----------.....-----M. 68 D--------VKRLIGRKFDDQEVVK..DRSLLPY........EIVNNQGK---.....---PNI. 69 KGVVYNIEKTGQCLTSIMQKLKNNL..KQDITH-........VYVGVGGQSIR.....SVKNVI. 70 DGVIADFEVTEAMLKHFINKLNVKG..LFSKPR-........-----------.....-----M. 71 -NPENTVFDAKRLIGRRFDEETVQS..DIKHWP-........-----FTVKGK.....QGKPVV. 72 DGQVHDVLGVAETVKEVKERLESRN..EIELKE-........VAVALAGRFLK.....TQVGEA. 73 HGCVHNIDEAAAIIRRIVNQLNENLedNTHITS-........LYVGVGGQSIA.....SQEFIV. 74 -------FDAKRLIGRKFDDPSVQS..DMKHWPF........KVIAGPGD---.....--KPLI. 75 DGVIADIENTEKMIKYFINQIFSRK..KLFFKP-........-----------.....----RM. 76 -------------------------..-------........-----------.....------. 77 -------------------------..-------........-----------.....---PNI. 78 -------FDAKRLIGRKFTDSIVQS..DMKLWPF........DVVDESGR---.....---PKI. 79 -------------------------..-------........-----------.....------. 80 -------------------------..-------........-----------.....------. 81 TNPTNTLSGTKRLIGRRFDDPQTQK..EMKMVP-........YKIVRGSNGDA.....WVEANG. 82 NNPHNTIFAIKRLMGLRYSDKEVQN..ELKRLPY........KVIDQDNR---.....---PFV. 83 -NPERTFFAVKRLIGRRYDDPMVEK..DKKLVPY........KIVKASNGD-A.....WVEADG. 84 -------------------------..-------........-----------.....------. 85 ------LSGTKRLIGRRFDDPQTQK..EMKMVP-........YKIVKGSNGDA.....WVEANG. 86 -------------------------..-------........-----------.....------. 87 -------------------------..-------........-----------.....------. 88 -------------------------..-------........-----------.....------. 89 -------------------------..-------........-----------.....------. 90 -------------------------..-------........-----------.....------. 91 -------------------------..-------........-----------.....------. 92 -------------------------..-------........-----------.....------. 93 -------------------------..-------........-----------.....------. 94 -------------------------..-------........-----------.....------. 95 -------------------------..-------........-----------.....------. 96 -------------------------..-------........-----------.....------. 97 -------------------------..-------........-----------.....------. 98 -------------------------..-------........-----------.....------. 99 -GYLLD-----------------LL..GKTIDN-........PIVDLYRKRFP.....YYNIVGd 100 110 120 130 140 | | | | | 1 .....ERDF...GEE.KRSITLDILSEMQSEALEK....LKENGKTPLHIFSKRYLLDDERIVFN 2 .....IVAI...RD-.-REVNPADIERVLDAAQAV....AIPADQRVLHTLAQDYVIDNQEGVRE 3 .....IVAI...RD-.-REVSLADLERVLDAAQAV....AIPADQRVLHTLPQDYVIDNQEGVRE 4 .....MVPI...SE-.-EEVTQEDVENVVHTAKSV....RVRDEHRVLHVIPQEYAIDYQEGIKN 5 .....MVPI...SE-.-EEVTQEDVENVVHTAKSV....RVRDEHRVLHVIPQEYAIDYQEGIKN 6 .....VVKI...KD-.-GEVTQADIDRAIETAKAI....NIPPDQKILDAVVQDYIIDTQLGVRE 7 .....VVKI...KD-.-GEVTQADIDRAIETAKAI....NIPPDQKILDAVVQDYIIDTQLGVRE 8 .....IVPI...SE-.-DEVTKEDIENVIHTAKSV....KILNEHHILHVIPQEYSIDQQSGIKN 9 .....FVPI...AE-.-SEVTQEEIDSALHTASSI....KLPEGLSLLHVIPQEYAVDRQMNIKN 10 .....VVAV...SSE.NKEIQVEDVRRVMAAAQVV....SVPHEQLIVDVIPKQFIVDGRDEITD 11 .....TIDL...GG-.-QEVEANDLKKVLAAAGHQ....SLRTDRAILHSLPTGFSLDGERGIRD 12 .....LAAI...RRQ.-QEISPPDVERAIENARAV....PLDPSLEILHTIPQEYVVDGQEGIKN 13 .....ERDF...GEE.KRSITLDILSEMQSEALEK....LKENGKTPLHIFSKRYLLDDERIVFN 14 .....SIDL...GG-.-QEVEASDLRKVLVAASQQ....SMRQDRAILHSLPTGYSLDGERGIRD 15 .....TISI...STK.SSEIEESHIQRLHERCLMK....AKEEGYEIVYTAPRKYILDDHTEVKN 16 .....VVAI...NSK.TREINEEDVERVIEAAKAI....VIPMDREILHVIPQEFIVDGIPHIKN 17 .....VVAI...NSK.TREINEEDVERVIEAAKAI....VIPMDREILHVIPQEFIVDGIPHIKN 18 .....TVCL...DG-.-HEVTPYDVRMALADVSRK....AFDAEHHIVHTVPAFYALDGNKGIVD 19 .....MIPV...TSD.TKEITDQDVENVVKSALTK....SMTPDREVITFIPEEFIVDGFQGIRD 20 .....GVAS...TKD.-NVVTIDEINRAINNACAKa...GLDNDKHILHALPYRFTLDKQE-VND 21 .....MIAV...NGD.SKEITDEDVRNVASAALVR....SIPPERQIVSILPQDFTVDGFEGIKD 22 .....GVAS...TKD.-NVVTIDEINRAINSACAKa...GLDNDKHILHALPYRFTLDKQE-VND 23 .....EVAL...NG-.-QRIEEIHMETLLATGRDA....IDPDGHMVLHAQPALYTLDGLKGVKS 24 .....VVAVadkGKG.HREVDQSDIDRVLEVACAV....SLPPDRKILHVIPKVYSVDDQHGITD 25 .....VVNI...PN-.-HEIGIKEIHRAVSTAKHTa...NLPSGYEIIHVLPYNFKVNDLEHVDD 26 .....MVPI...VSD.TKEITDNDVIQVVQNALMR....GIVPEREIIAVETKEFTVDGFTGISD 27 .....TIKI...NG-.-QTVTQQDIKKLLQKALVE....FKFKNQEIIHYFPLEFTLDNNS-VEN 28 .....MIAV...SSE.SKEITDEDVCNVASAALVR....STPPERQIVAILPQDFTVDGFEGIKD 29 .....QVEF...KGE.TKEFTPEEISSMVLTKMREtaeaYLGGTVNNAVVTVPAYFNDSQRQATK 30 .....LICC...PTN.ITSVEQKAIKEAAEK----....-------------------------- 31 .....VVCV...PSG.ITGVERRAVIEASSQ----....-------------------------- 32 .....MVCV...PYG.LTSVERNAVKESTLS----....-------------------------- 33 .....MVCV...PYG.LTSVERNAVKESALS----....-------------------------- 34 .....MVCV...PYG.LTSVERNAVKESALS----....-------------------------- 35 .....QVEF...RGE.GKHFTPEGISSMFRRKKREiaesYLGGTVNNAVVTVPAYFNDSQRQVTK 36 .....VIGI...PSC.ITDVECRAVHESASK----....-------------------------- 37 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 38 .....EIDF...YED.-TEINGSHIEKVLEGIREK....NDVQETEVINVFPIRFIVDKENEVSD 39 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 40 .....MVCV...PSG.ITAVEERAVIDATRQ----....-------------------------- 41 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 42 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 43 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 44 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 45 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 46 .....MVCV...PSG.ITAVEERAVIDATRQ----....-------------------------- 47 .....LICC...PTN.ITSVEQKAIREAAER----....-------------------------- 48 .....----...---.-EEFSPEEISSMVLIKMKEtaeaYLGGTVSKAVVTVPAYFNDSQRQATK 49 .....QVEF...KGE.TKTFTPEEISSMVLLKMREsaeaFLGGKVTDAVVTVPAYFNDSQRQATK 50 .....EVKV...GSE.TKQFTPEEVSAMVLTKMKQiaesYLGHEVKNAVVTVPAYFNDAQKQATK 51 .....VVCT...PSG.STAVERRAISDAVKN----....-------------------------- 52 .....IVNI...AGE.KKTFTPEEISAMVLRKMKEiaesYLGRTVTHAVVAVPAYFNDAQRQATK 53 .....EVNI...AGE.KKTFTPEEISAMVLRKMKEiaesYLGRTVTHAVVTVPAYFNDAQRQATK 54 .....IISV...PYG.LTQVERKAVRESALS----....-------------------------- 55 .....QVDV...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 56 .....EVTY...QGE.KKTFHPEEVSAMVLGKMKEiaeaYLGKEVKEAVITVPAYFNDSQRQATK 57 .....EVTY...QGE.KKTFHPEEVSAMVLGKMKEiaeaYLGKEVKEAVITVPAYFNDSQRQATK 58 .....EVTY...QGE.KKTFHPEEVSAMVLGKMKEiaeaYLGKEVKEAVITVPAYFNDSQRQATK 59 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 60 .....RVEY...KGE.DKAFYPEEISSMVLVKMKEiaeaYLGQKVSNAVITVPAYFNDSQRQATK 61 .....VVCV...PSG.ITGVERRAVIEASSQ----....-------------------------- 62 .....EVSV...KGE.KKVFTPEEISGMILGKMKQiaedYLGTKVTHAVVTVPAYFNDAQRQATK 63 .....EVEV...KGE.KRQFNPEEISAMVLQKMKEtaetYLGHTVKDAVITVPAYFNDSQRQATK 64 .....QVQT...SQG.DKVFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 65 .....QAEY...RGE.NKLFAPEEISSMVLTKMKEtaeaYLGQKITDSVITVPAYFNDSQRQATK 66 .....QAEY...RGE.NKLFAPEEISSMVLTKMKEtaeaYLGQKITDSVITVPAYFNDSQRQATK 67 .....LICC...PTN.ITSVEQKAIKEAAEK----....-------------------------- 68 .....KVQI...KDK.DTTFAPEQISAMVLEKMKEiaqsFLGKPVKNAVVTVPAYFNDAQRQATK 69 .....VKDL...PSA.-TQVTQEMVNELMDANRNM....SYP-DLEILDAATQEYKLDNQF-QLD 70 .....LICC...PTN.ITSVEQKAIKEAAEK----....-------------------------- 71 .....EVEV...KGE.KREFNAEEISAMVLQKMKEtaeaVLGHSVRDAVITVPAYFNDSQRQATK 72 .....ELDF...SK-.VGHITREDVMKLEIEAVTKaqe.SVEEDFFCVGYSVVEYRLDGMW-MKK 73 .....RKAM...VPE.GEVIRTEHIESLWAEMRGA....SFP-DKEVLDVTDPLFYVDGKQ-EIQ 74 .....EVTY...QGE.KKTFHPEEVSAMVLGKMKEiaeaYLGKEVKEAVITVPAYFNDSQRQATK 75 .....VIGV...PTC.ITEVERRAVKESAMN----....-------------------------- 76 .....----...---.--------------ETAES....YLGGTVNNAVVTVPAYFNGSQRQATK 77 .....EVTF...QGE.RKTFHAEEISSMVLTKMKEiaeaFIGKTVKDVVITVPAYFNDSQRQATK 78 .....KVTH...QCK.DKTFFAEEISSMVLGKMKEtaeaYLGKTVNDAVITVPAYFNDSQRQATK 79 .....----...---.-------------------....-------------------------- 80 .....----...---.---FAPEQISAMVLEKMKEiaqsFLGKPVKNAVVTVPAYFNDAQRQATK 81 .....QQYS...PTQ.IGAFILTKMKETAEAYLGK....----SINKAVITVPAYFNDAQRQAIK 82 .....EVQY...KGK.TEHYSPEEISAMILSKMKTiaeeYLGRPVKNAVVTCPAYFNDAQRKATA 83 .....----...---.-QTYSPSQVSAFILQKMKEtaeaHLGQKVDQAVITVPAYFNDAQRQATK 84 .....----...---.-------------------....-------------PAYFNDAQRQATK 85 .....QQYS...PSQ.IGAFILTKMKETAEAYLGK....----SINKAVITVPAYFNDAQRQATK 86 .....----...---.-------------------....---------------YFNDAQRQATK 87 .....----...---.-----------------ES....YLGSKVKNVVITVPAYFNDSQRQATK 88 .....----...---.-------------------....-------------------------- 89 .....----...---.-------------------....-------------------------- 90 .....----...---.-------------------....-------------------------- 91 .....----...---.-------------------....-------------------------- 92 .....----...---.-------------------....-------------------------- 93 .....----...---.-------------------....-------------------------- 94 .....----...---.-------------------....-------------------------- 95 .....----...---.-------------------....-------------------------- 96 .....----...---.-------------------....-------------------------- 97 .....----...---.-------------------....-------------------------- 98 .....----...---.-------------------....-------------------------- 99 perntVVFR...KSD.TDEFSVEELVAQLLVKAKQfaqeSVQQPITECVLTVPGYF--------- 150 160 170 180 190 200 | | | | | | 1 PLDMKASK.IAIEYTSIVVPLKVYEMFYNFLQ.DTVKSPFQLKSSLVSTAEGVLTTP.....EKD 2 PLGMSGVR.LEAKVHVVTCAVNASQNIEKCVR.RCGLEVDDIILEQLASAYSVLTED.....EKE 3 PLGMSGVR.LEAKVHVVTCAVNAAQNIEKCVR.RCGLEIDDIILEQLASAYSVLTDD.....EKE 4 PVGLSGVR.MQAKVHLITCHNDMAKNIVKAVE.RCGLKVDQLIFAGLASSYSVLTED.....ERE 5 PVGLSGVR.MQAKVHLITCHNDMAKNIVKAVE.RCGLKVDQLIFAGLASSYSVLTED.....ERE 6 PIGMSGVR.LDTRVHIITGASTAVQNVQKCIE.RCGLKSDQIMLQPLASGQAVLTED.....EKD 7 PIGMSGVR.LDTRVHIITGASTAVQNVQKCIE.RCGLKSDQIMLQPLASGQAVLTED.....EKD 8 PIGLSGTR.MQVRVHLITCHQNMAKNIIKAVE.KCDIKVDQVIFSGLASSKAVLTED.....ECK 9 PLGLQGVR.LKAQVHLIACHQDWQNNLKKAVE.RCGLQVDKVVFSGFAATHSVLTED.....EKD 10 PKKMLGVR.LEVEGTLITGSKTILHNLLRCVE.RAGIEITDICLQPLAAGSAALSKD.....EKN 11 PLAMFGDV.LGVDMHVLTAERPALKNLELCVN.RAHLSVEGMVATPYASGLAALVDD.....EVE 12 PVGMHGVR.LEVDVHIVAGSAGPLLNLRRCVQ.EAGLQIEGFVLHSLASGLATLDHS.....EQN 13 PLDMKASK.IAIEYTSIVVPLKVYEMFYNFLQ.DTVKSPFQLKSSLVSTAEGVLTTP.....EKD 14 PLSMYGDL.LGVDMHVVTVERTALKNLELCVN.RAHLSVEGMVATPYASGLAALVDD.....EVE 15 PLGLVGSK.LSVEMHVVKVSTTILRNLEKAIR.EVGLNPVGRTVNAIASADSVLTHD.....EKE 16 PIDMMGIR.LEGGVHIITGSSSSSQNLVRCVN.RAGFAVDEVVLGSLASSYATLSKE.....ERE 17 PIDMMGIR.LEGEVHIITGSSSSSQNLVRCVN.RAGFAVDEVVLGSLASSYATLSKE.....ERE 18 PIGMIGKT.LGVNVHVVTAETAPLRNLETCIN.RAHLSVEAMVATPFASGLSVLIND.....EAR 19 PRGMMGVR.LEMRGLLYTGPRTILHNLRKTVE.RAGVQVENVIISPLAMVQSVLNEG.....ERE 20 PLGMSGTR.LEVFIHIVYTEKNNIENLEKIMI.QSGVEIENIVINSYAASIATLSND.....ERE 21 PRGMIGVR.LEMYGLLFTGPKTIVHNIRKCVE.NAGLVVNELVITPLALTETILSDG.....EKD 22 PLGMSGTR.LEVFIHIVYTEKNNIENLEKIMI.QSGVEIENIVINSYAASIATLSND.....ERE 23 PIGLYADR.LGVDIHVIAAEPSPVRYLELAVR.SAHLEVQAIVAAPIAAGMSCLFAE.....ERE 24 PRNIIGVR.LEGEVHMITGSATCMRSVIDCVK.RANLHIDFLMHNGLAAVRSVLNDD.....ERN 25 PLGMSGNR.LEVSTHIVISQESHIKNLKKAVE.LADLRVDNIVLSGYASAIACLDDS.....EKE 26 PRGMFGVR.LEIRGVVYTGPKTLVHNVRKVVE.RAGLLVDNIVIAPLAMRQYVLTEG.....ERE 27 PIGMYGRA.LSCELHIISARSNLLSNIVQCFA.KCHVEVTNITLAIYASAISCLTND.....EKN 28 PRGMLGVR.MEMFGVVYTGPKTIIHNIRKCVE.KAGLGINELVITPLALTETILTDG.....EKD 29 DAGLI---.-----------------------.-AGLNVLRIINEPTAAAIAYGLDKka...DGE 30 --------.-----------------------.-SGGKHVYLEEEPKVAAIGAGMEI.....FQP 31 --------.-----------------------.-AGARQVHIIEEPMAAAIGSGLPV.....HEA 32 --------.-----------------------.-AGAREVFLIEEPMAAAIGAGLPV.....KEP 33 --------.-----------------------.-AGAREVFLIEEPMAAAIGAGLPV.....KEP 34 --------.-----------------------.-AGAREVFLIEEPMAAAIGAGLPV.....KEP 35 DAGLI---.-----------------------.-AGLNVLRIINEPTAAAIAYGLDKka...EGE 36 --------.-----------------------.-AGAGEVEVLEESLAAAIGANIPI.....EEP 37 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 38 PKELIARHsLKVEAGVIAIQKSILINMIKCVE.ACGVDVLDVYSDAYNYG-SILTAT.....EKE 39 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 40 --------.-----------------------.-AGARDAYPIEEPFAAAIGANLPV.....WEP 41 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 42 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 43 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 44 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 45 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 46 --------.-----------------------.-AGARDAYPIEEPFAAAIGANLPV.....WEP 47 --------.-----------------------.-SGGKTVFLEEEPKVAAVGAGMEI.....FQP 48 DAGTI---.-----------------------.-AGLEVLRIINEPTAAAIAYGLDKks...EGE 49 DAGLI---.-----------------------.-AGLNVLRIINEPTAAAIAYGLDRsn...QHE 50 DAGSI---.-----------------------.-AGLNVVRIINEPTAAAIAYGLDKk....DGE 51 --------.-----------------------.-CGAKNVHLIEEPVAAAIGADLPV.....DEP 52 DAGTI---.-----------------------.-AGLNVLRIVNEPTAAAIAYGLDKk....EGE 53 DAGTI---.-----------------------.-AGLNVLRIVNEPTAAAIAYGLDKk....EGE 54 --------.-----------------------.-AGAREVFLIEEPMAAAIGASLPI.....QEP 55 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 56 DAGTI---.-----------------------.-AGLSVLRIINEPTAAAIAYGLDKkg...CGE 57 DAGTI---.-----------------------.-AGLSVLRIINEPTAAAIAYGLDKkg...CGE 58 DAGTI---.-----------------------.-AGLSVLRIINEPTAAAIAYGLDKkg...CGE 59 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 60 DAGVI---.-----------------------.-AGLNVLRIINEPTAAAIAYGLDKgk...SGE 61 --------.-----------------------.-AGARQVHIIEEPMAAAIGSGLPV.....HEA 62 DAGTI---.-----------------------.-AGLNVLRIVNEPTAAAIAYGLDKs....DKE 63 DAATI---.-----------------------.-AGLNAIRIINEPTAAALAYGLDKgi...QDE 64 DAGTI---.-----------------------.-SGLNVMRIINEPTAAAIAYGLDKk....EGE 65 DAGAI---.-----------------------.-AGLNVLRIINEPTAAALAYGLDKgh...KGE 66 DAGAI---.-----------------------.-AGLNVLRIINEPTAAALAYGLDKgh...KGE 67 --------.-----------------------.-SGGKHVYLEEEPKVAAIGAGMEI.....FQP 68 DAGTI---.-----------------------.-AGLNIVRIINEPTAAALAYGLDK.....KEE 69 PVGIQCTH.LEGNFLNILWRKNFYRNLNTCFD.NAGIAIAEMYLAPLALADSTLTDA.....EKR 70 --------.-----------------------.-SGGKHVYLEEEPKVAAIGAGMEI.....FQP 71 DAATI---.-----------------------.-AGLNAIRIINEPTAAALAYGLDKgi...TDE 72 LEGHRGGK.AYVKVVSAFLPVHVVDSLMRVLE.TVGLTPVHVTLEPIAAMDLTVPED.....LRY 73 AKGVFCHE.LEARFQLITARRSVKQNIRIAIEeRLGLRLAGILVTPLCEAQVLLSDD.....ELT 74 DAGTI---.-----------------------.-AGLSVLRIINEPTAAAIAYGLDKkg...CGE 75 --------.-----------------------.-AGAREVKVIEESLAAAIGSDIPI.....FEP 76 DAGLI---.-----------------------.-AGLNVLRIINEPTAAAIAYGLDKka...EGE 77 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKks...GGE 78 DAGVI---.-----------------------.-ARINVLRIINEPIAAAIAYGLDKkgnt.QGE 79 --------.-----------------------.-------------LASAYSVLTED.....EKE 80 DAGTI---.-----------------------.-AGLNIVRIINEPTAAALAYGLDK.....KEE 81 DAGAI---.-----------------------.-AGLDVQRIINEPTAAALSYGMNS.....KEG 82 DAGTI---.-----------------------.-AGLNVVRILNEPTAASLAYGLNK.....KGS 83 DAGKI---.-----------------------.-AGLEVLRIINEPTAAALAYGLDK.....TKT 84 DAGKI---.-----------------------.-AGLNVLRILNEPTAAAMAYGLNKv....TGE 85 DAGRI---.-----------------------.-AGLDVQRIINEPTAAALSYGMNS.....KEG 86 DAGAI---.-----------------------.-AGLNVLRIINEPTAAALAYGLDKgq...KGE 87 DAGKI---.-----------------------.-AGMEVLRVINEPTAAALAYGLDR.....TDD 88 --------.-----------------------.---------------AAIAYGLDKka...EGE 89 --------.-----------------------.IAGLEVERIINEPTAAALAYGLEK.....KKN 90 ---AI---.-----------------------.-AGLNVLRIINEPTAAALAYGLDKgq...KGE 91 --------.-----------------------.IAGLEVLRIVNEPTAAALAYGSDK.....KKD 92 --------.-----------------------.-AGLEVLRIVNEPTAAAIAYGRDRsse..GAM 93 --------.-----------------------.----------------AIAYGLDKkg...KGE 94 --------.-----------------------.IAGLEVLRIVNEPTAAALAYGLDK.....KKD 95 --------.-----------------------.-AGLEVERIINEPTAAALAYGFDKk....NVN 96 --------.-----------------------.------------------------.....--- 97 --------.-----------------------.------------------------.....--- 98 --------.-----------------------.------------------------.....--- 99 --------.----------GQAEREALLSAAQ.LANLKVLQLINDYAAVALNYGVFHrgeinETA 210 220 230 240 250 | | | | | 1 RGVVVVNLGYNFTGLIAYKNGVPIK........ISYVPVGMKHVIKDVS........AVLDTSFE 2 LGVCLVDIGGGTTDIAIFTEGAIRH........TAVIPIAGDQVTNDIA........MALRTPTQ 3 LGVCLVDIGGGTTDIAIFTEGAIRH........TAVIPIAGDQVTNDIA........MALRTPTQ 4 LGVCVVDIGGGTMDIAVYTGGALRH........TKVIPYAGNVVTSDIA........YAFGTPPS 5 LGVCVVDIGGGTMDIAVYTGGALRH........TKVIPYAGNVVTSDIA........YAFGTPPS 6 LGVCVIDIGGGTTDIAVYMNGAIRH........TSVIPAGGNLITKDLS........KSLRTPLD 7 LGVCVIDIGGGTTDIAVYMNGAIRH........TSVIPAGGNLITKDLS........KSLRTPLD 8 LGVCMIDIGGGTIDLITYIDGSIQD........SQVIPYAGNIVTKDIS........YAFSTSYS 9 LGVCLIDFGAGTMNVMVYTNGALRF........SKVIPYAGNIVTNDIA........HACTISRA 10 LGVALIDIGGGSTTIAVFQNGHLTS........TRVIPLGGENITKDIS........IGLRTSTE 11 LGCAAIDMGGGTTTISVFAEGKLVH........ADAVGLGGHHVTTDLA........RGLSTRIE 12 QTTVVVDMGGGTTDIGVFKRGNLAH........SASIPIGGDHVTADLA........QILKIPME 13 RGVVVVNLGYNFTGLIAYKNGVPIK........ISYVPVGMKHVIKDVS........AVLDTSFE 14 LGCAAIDMGGGTTTISVFAEGRLIH........TDAIGLGGHHVTTDLA........RGLSTRIE 15 DGVLLLDMGAGLTDYSLYTEGRPYI........TGVVPFGGINITKDLS........YMLKIDTE 16 MGVLFIDMGKGTTDIILYIDGSPYY........TGVIPIGVNRVTLDIA........QVWKVPED 17 MGVLFIDMGKGTTDIILYIDGSPYY........TGVIPIGVNRVTLDIA........QVWKVPED 18 LGAACIDLGGGTTTLSVFSEGKFVH........TDVLPVGGHHVTLDVA........RGFSMSIE 19 FGATVIDMGAGQTTVATIRNQELQF........THILQEGGDYVTKDIS........KVLKTSRK 20 LGVACVDMGGETCNLTIYSGNSIRY........NKYLPVGSHHLTTDLS........HMLNTPFP 21 FGTIVIDMGGGQTTTAVMHDKQLKF........TSLDQEGGEFVTKDIS........IVLNTSFN 22 LGVACVDMGGETCNLTIYSGNSIRY........NKYLPVGSHHLTTDLS........HMLNTPFP 23 LGVALVELGAGVTNVSLFAGGLLVG........LTSIPMGASDITDDIA........AAFGTRRS 24 VGCVLINIGGGTTDVIAMYKGSPVL........ITSIPVGGSQVTSDLA........KVKNLPLE 25 LGAVLIDMGGAICDMVVHTGNSIRY........NDCLQIGSINITQDLS........MALHTPLK 26 FGTIMVDLGAGQTTVSIVKDQSLKF........THTSPEGGDYVTKDIS........TVLNTSVS 27 LGVLIIDIGDQTTSCGIFFADKLIY........TWHLNIGSFHISLDIA........KVFGIDLV 28 FGTIVIDMGGGQTTTSVIHDKQLKF........THVNQEGGEFITKDIS........IVLNTSFN 29 RNVLIFDLGGGTFDVSLLTIEEGIFevkst...AGDTHLGGEDFDNRLVnhf20eraRALRRSPT 30 SGNMVVDIGGGTTDIAVISMGDIVT........SSSIKMAGDKFDMEILnyikre..YKLLIGER 31 TGNMVVDIGGGTTEVAVISLGGIVT........AQSIRVAGDELDNAIIqhvkke..YSLLLGER 32 QGSLIVDIGGGTTEIGVISLGGLVI........SKSIRVAGDKLDQSIVeyirkk..FNLLIGER 33 QGSLIVDIGGGTTEIGVISLGGLVI........SKSIRVAGDKLDQSIVeyirkk..FNLLIGER 34 QGSLIVDIGGGTTEIGVISLGGLVI........SKSIRVAGDKLDQSIVeyirkk..FNLLIGER 35 RNVLILDLGGGTFDVSLLTIEEGIFevkst...AGDTHFGGEDFDNRLVnhf19snaRALRRLRT 36 AGNMVCDIGGGTTEVSVISLLGMVV........TNAIRVGGDEFDQAIIkhvrsv..HNLIIGEQ 37 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 38 LGACVIDIGEDVTQVAFYERGELVD........ADSIEMAGRDITRRYCtri.....KALLMKL- 39 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 40 TGSMVVDIGGGTTEVAIISLGGIVT........SQSIRVAGDEMDDAIInyirkt..YNLMIGDR 41 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 42 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 43 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 44 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 45 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 46 TGSMVVDIGGGTTEVAIISLGGIVT........SQSIRVAGDEMDDAIInyirkt..YNLMIGDR 47 SGNMVVDIGGGTTDIAVLSMGDIVT........SSSIKMAGDKFDMEILnyikrk..YKLLIGER 48 KNVLIFDLGGGTFDVSLLTIEEGIFevkat...AGDTHLGGEDFDNRLVnhf19snaRALRRLRT 49 TNVLIFDLGGGTFDVSLLTIEEGIFevkat...AGDTHLGGEDFDSRLVnhf19gnaRAVRRLRT 50 RNILVFDLGGGTFDVSLLTIDSGVFevlat...NGDTHLGGEDFDQRVMeyf19kdnRAVQKLRR 51 VANVVVDIGGGTTEVAIISFGGVVS........CHSIRIGGDQLDEDIVsfvrkk..YNLLIGER 52 RLIIVYDLGGGTFDVSLLSIEDGVFeviat...AGDTHLGGEDFDHQVMsyf19ddpKALGKLKR 53 RLIIVYDLGGGTFDVSLLSIEDGVFeviat...AGDTHLGGEDFDHQVMahf19sdpKALGKLKR 54 KGNLVVDIGGGTTEIGVISLGGLVI........SKSIRTAGDKLDMSIVnyvkek..YNLIIGER 55 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 56 MNVLIFDMGGGTFDVSLLTIEDGIFevkat...AGDTHLGGEDFDNRLVdfc20tnsRALRRLRT 57 MNVLIFDMGGGTFDVSLLTIEDGIFevkat...AGDTHLGGEDFDNRLVdfc20tnsRALRRLRT 58 MNVLIFDMGGGTFDVSLLTIEDGIFevkat...AGDTHLGGEDFDNRLVdfc20tnsRALRRLRT 59 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 60 RNVLIFDLGGGTFDVSILTIEDGIFevkst...AGDTHLGGEDFDNRMVnhf19qnkRALRRLRT 61 TGNMVVDIGGGTTEVAVISLGGIVT........AS-PSVAGDELDNAIIqhvkke..YSLLLGER 62 HQIIVYDLGGGTFDVSLLSIENGVFevqat...SGDTHLGGEDFDYKIVrql19dnnKALAKLKR 63 KNVLIFDLGGGTFDVSILSIAEGSIfevkst..AGDTHLGGEDFDQRMLqhf19pnpRAIRRLRT 64 KNVLVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 65 KNVLIFDLGGGTFDVSILTIDEGSMfevkat..AGDTHLGGEDFDNRMVthf19snpRAIRRLQT 66 KNVLIFDLGGGTFDVSILTIDEGSMfevkat..AGDTHLGGEDFDNRMVthf19snpRAIRRLQT 67 SGNMVVDIGGGTTDIAVISMGDIVT........SSSIKMAGDKFDMEILnyikre..YKLLIGER 68 TSILVYDLGGGTFDVSILVIDNGVFevyat...AGNTHLGGEDFDQRVMdyf19tdkRAIQKLRK 69 SGCVLIDLGADTTTVSVYYKNILRH........LAVIPLGGSNITKDI-........ASLQMEDS 70 SGNMVVDIGGGTTDIAVISMGDIVT........SSSIKMAGDKFDMEILnyikre..YKLLIGER 71 KNILIFDLGGGTFDVSILSIAEGSIfevkst..AGDTHLGGEDFDSRVLqhf19snpRAIRRLRT 72 LNISLVDVGAGTSDIAISKEGTVVA........YGMIPMAGDEITEAIG........KKFLLDFQ 73 LGCCYVNIGAGCTSVSIYKNRLLAM........LRVLPMGGYNVTRDL-........TSLRLTEQ 74 MNVLIFDMGGGTFDVSLLTIEDGIFevkat...AGDTHLGGEDFDNRLVdfc20tnsRALRRLRT 75 TGHMVCDIGGGTTEISVISLGGMVV........SRAIRTGGDEFDESIIkymrns..HNIIIGQQ 76 RNVLIFDLGGGTFDVSLLTIEEGIFevkst...AGDTHLGGEDFDNRLVnhf19snaRALRRLRT 77 KNVLIFDLGGGTFDVSILTIEDGIFevkat...AGDTHLGGEDFDNLLVehc20snkRALRRLRT 78 RNVLIFDLGGGTFDVSILSIEDGIFevkst...NGDTHLGGEDFDNRMVnhf19nnkRSLRRLRT 79 LGVCLVDIGGGTTDIAIFTEGAIRH........TAVIPIAGDQVTNDIA........MALRTPTQ 80 TSILVYDLGGGTFDVSILVIDNGVFevyat...AGNTHLGGEDFDQRVMdyf19tdkRAIQKLRK 81 L-VAVFDLGGGTFDVSILEISNGVFevkat...NGDTFLGGEDFDNALLefl19kdkLALQRLRE 82 KKILVFDLGGGTFDVSCLAVDDGLFevlat...GGDTHLGGEDFDDRTIeyl19knaKAMAKLKR 83 GTIAVYDLGGGTFDISILEIGDGVFevkst...NGDTFLGGEDFDMRLVgyl19ndkLALQRLKE 84 KNILVFDLGGGTFDVSLLNIEENVFdvvst...SGDTHLGGSDFDQKVTeyl19kdkRAVTRLRR 85 L-VAVFDLGGGTFDVSILEISNGVFevkat...NGDTFLGGEDFDNALLefl19kdkLALQRLRE 86 KHVLIFDLGGGTFDVSVLAIDEGSIfevkat..AGDTHLGGEDFDNRLVahf19knaRAIRRLRT 87 KTIAVYDLGGGTFDISVLEIQKGVFevkst...NGDTFLGGEDFDNELLrfl19kdpMALQRVKE 88 RNVLIFDLGGGTFDVSLLTIEEAIFevkst...AGDTHLGGEDFDNRLVnhf19fnaRALRRLRT 89 EKIVVFDLGGGTFDVSVLEVTEELVevlst...NGDTHLGGDDFDEELInfi19kdpMALQRLRE 90 KHVLIFDLGGGTFDVSVLAIDEGSIfevkat..AGDTHLGGEDFDNRLVahf19knaRAIRRLRT 91 ETIAVYDFGGGTFDISILEVGEGVVevkst...NGDTHLGGDNIDQKVMdwi19kdkMALQRLKE 92 KTVLIFDLGGGTFDVTLLNIDGGLFevrat...AGDTHLGGEDFDSRLVdyf19gnaRAMRRLRT 93 RNILIFDLGGGTFDVSLLTIDDGIFevkat...AGDTHLGGEDFDNRMVnyf19gnpRALRRLRT 94 ETIAVFDFGGGTFDISILEVGEGVVevkst...NGDTHLGGDDIDEALVgwi18aqdKMALQRLK 95 SKIAVYDLGGGTFDISILELADGVFevkst...NGDTHLGGDDFDMAIMewm19adkNTVQRLKE 96 -------------------------........------GGEDFDNRMVnhf19gnpRALRRLRT 97 -----------------LNINGGVFavkat...AGDTHLGGEDFDNALLehf19ddaRALRRLRS 98 -------------------------........----------------........-------- 99 QYFLFYDMGAYKTSAAVVSYQLVKDkqt15lgvGYDRTLGGLEIQLRLRdyl21tspRALAKLFK 260 270 280 290 300 | | | | | 1 ESERLIITHGNAVYNDLK......EEEIQYRGLD...GNT....I....KTTTAKKL.SVIIHAR 2 YAEEIKIRYACALAKLAGa.....GETIKVPSVG...DRP....P....RELSRQAL.AEVVEPR 3 YAEEIKIRYTCALAKLAGa.....GETIKVPSVG...DRP....P....RELSRQAL.AEVVEPR 4 DAEAIKVRHGCALGSIVGk.....DESVEVPSVG...GRP....P....RSLQRQTL.AEVIEPR 5 DAEAIKVRHGCALGSIVGk.....DESVEVPSVG...GRP....P....RSLQRQTL.AEVIEPR 6 AAEYIKIHYGVASCDTEGl.....GEMIEVPGVG...DRT....S....RQVSSKVL.AAIISAR 7 AAEYIKIHYGVASCDTEGl.....GEMIEVPGVG...DRT....S....RQVSSKVL.AAIISAR 8 DSEKIKIKYGSAIKLSPGt.....SKNIDLSSKY...GNF....Q....KNLQQDTV.IEVIDSR 9 EAERIKVNYASAFYPARLhg....DKKIEVASIG...GRA....P....RSLTKSDL.SLITSAR 10 EAERVKKQLGHAYYDEASe.....DEIFEVTVIG...TNQ....K....QTFTQQEA.ANIIEAR 11 DAERLKVVHGSALPNSADe.....RDIISVPPIGeddRDQ....P....THVPRALV.SRIVRAR 12 EAEKVKRHYGAAIPELAD......QELTLEITTA...SGA....T....HAISAYEL.SRVIRPR 13 ESERLIITHGNAVYNDLK......EEEIQYRGLD...GNT....I....KTTTAKKL.SVIIHAR 14 DAERLKVVHGSALLNGADe.....RDMISIPPIGeddRDQ....P....SQVSRALV.TRIVRAR 15 TAESVKVNHGVAFESLVDd.....EDVVKIKPRG...EDR....E....IPIQKKQV.AEIIQSR 16 VAENIKITAGIAHPSILEsq....METVIIPNLG...TRP....P....QEKSRKEL.SVIINSR 17 VAENIKITAGIAHPSILEsq....METVIIPNLG...TRP....P....QEKSRKEL.SVIINSR 18 EAERLKIVYGSTFSMSADd.....RCMINVLEIGn..GHH....E....TEYPRAVL.GRIIRAR 19 LAEGLKLNYGEAYPPLAS......KETFQVEVIG...EVE....A....VEVTEAYL.SEIISAR 20 YAEEVKIKYGDLSFESGAetpsq.SVQIPTTGSD...GHE....S....HIVPLSEI.QTIMRER 21 NAEALKINYGDAYPERTSa.....NEEFPVDVIG...QSE....P....VKVDERYL.SEVISAR 22 YAEEVKIKYGDLSFEGGEetpsq.NVQIPTTGSD...GHE....S....HIVPLSEI.QTIMRER 23 DAERLKCFYGSAQSSPRDn.....HEMIDVAPIA...NDEdvidP....QRISRAQL.IGVIRKR 24 TAERIKIKDGCCWIPLLEg.....EGSVLISSQG...NRI....P....VEISKREI.AEIIEAR 25 EAEKIKLNYAALS--QQP......NTLIQIPSMGd..ERK....V....NEVSLDII.SNVIYAR 26 AAEDLKVNYGEASTERASq.....DEYFLVDVVG...KDE....P....EQITEYYL.SQIIEAR 27 TAEKLKILYGNAIIPLFEkds...IINMDDFHVDip.HNL....N....ISLTIYRL.AEVISAR 28 NAEALKINYGDAYPERTSa.....NEEFPVDVIG...KSE....P....VRVDERYL.SEIIEAR 29 ACERAKRTLSSAA---QT......SIEIDSLYEG...IDF....Y....TSITRARF.EELCQDL 30 TAEDIKIKVATVFPDARHeei...SIRGRDMVSG...LPR....T....ITVNSKEV.EEALRES 31 TAEQIKITIGSAYDLDSDeht...EIRGRDLVSG...LPK....T....VVISAAEV.RKAIEEP 32 TGEEIKIEIGCAIKLDPPltm...EVSGRDQVSG...LLH....T....IELSSDDV.FEAIKDQ 33 TGEEIKIEIGCAIKLDPPltm...EVSGRDQVSG...LLH....T....IELSSDDV.FEAIKNQ 34 TGEEIKIEIGCAIKLDPPltm...EVSGRDQVSG...LLH....T....IELSSDDV.FEAIKDQ 35 ACERAKRTLSSAA---QT......SIEIDSLYEG...IDF....Y....TSITRARF.EELCQDL 36 TAERLKIEIGNASPEKNIekv...EVKGTDAITG...LPR....R....LEIDSVEV.REALKEP 37 EVEKAKRALSSQH---QA......RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDL 38 ----LKKLNTNMVMHSMI......LLQIKISSLL...NRL....IvmkqYSIPQKDL.SDFIEAR 39 EVEKAKRALSSQH---QA......RIEIESFYEG...EDF....S....ETLTRAKF.EELNMDL 40 TAEAIKMEIGSAEAPEESdnm...EIRGRDLLTG...LPK....T....IEITGKEI.SNALRDT 41 EVEKAKRALSSQH---QA......RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDL 42 EVEKAKRALSSQH---QA......RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDL 43 EVEKAKRALSSQH---QA......RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDL 44 EVEKAKRALSSQH---QA......RIEIESFYEG...EDF....S....ETLTRAKF.EELNMDL 45 EVEKAKRALSSQH---QA......RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDL 46 TAEAIKMEIGSAEAPEESdnm...EIRGRDLLTG...LPK....T....IEITGKEI.SNALRDT 47 TSEDIKIKVGTVFPGARSeel...EIRGRDMVTG...LPR....T....ITVCSEEI.TEALKEN 48 ACERAKRTLSSAA---QT......SIEIDSLYDG...IDF....Y....TSITRARF.EELCQDL 49 ACERAKRTLSSSA---QA......SIEIDSLYEG...IDF....Y....TSITRARF.EELCADL 50 EVEKAKRALSTQH---QT......KIEIESLFDG...EDF....S....ETLTRAKF.EELNMDL 51 TAEQVKMEIGHALIEHIPeam...EIRGRDLVTG...LPK....T....IMLQSNEI.QDAMRES 52 EVEKAKRILSSQM---SA......RVDIESLYQG...IDF....S....ETLTRPKF.EEINMHL 53 EVEKAKRTLSSQM---SA......RVEIESLYQG...IDF....S....ETLTRAKF.EEINMHL 54 TGEEIKITIGSAIQLPKElsm...VVKGRDQVSG...LLS....R....IELTSEDV.REAMREY 55 EVEKAKRALSSQH---QA......RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDL 56 QCERTKRTLSSST---QA......TIEIDSLFEG...IDY....S....VSISRARF.EELCMDY 57 QCERTKRTLSSST---QA......TIEIDSLFEG...IDY....S....VSISRARF.EELCMDY 58 QCERTKRTLSSST---QA......TIEIDSLFEG...IDY....S....VSISRARF.EELCMDY 59 EVEKAKALSSQH----QA......RIEIESFYEG...EDF....S....ETLTRAKF.EELNMDL 60 AFERAKRTLSSSS---QA......SIEIDSLFEG...VDF....Y....TSITRARF.EELCSDL 61 TAEQIKITIGSAYDLDSDeht...EIRGRDLVSG...LPK....T....VVISAAEV.RKAIEEP 62 EAEKAKRALSSQM---ST......RIEIDSFVDG...IDL....S....ETLTRAKF.EELNLDL 63 ACERAKRTLSSSS---EA......CVEVDSLFEG...IDL....C....TKITRARF.EELCADL 64 EVEKAKRALSSSH---QV......KIEIESFFEG...DDS....S....ETLTRAKF.EELNMDL 65 ACERAKRTLSSSS---EA......SIEIDSLYEG...IDF....Y....TKITRARF.EELCGDL 66 ACERAKRTLSSSS---EA......SIEIDSLYEG...IDF....Y....TKITRARF.EELCGDL 67 TAEDIKIKVATVFPDARHeei...SIRGRDMVSG...LPR....T....ITVNSKEV.EEALRES 68 EVEIAKRNLSVVH---ST......QIEIEDILEG...HNF....S....ETLTRAKF.EELNDDL 69 DAEKMKIKYASAF--TEN......NEIDNTLSYS...IDA....D....RQIESRKF.IEIVEGR 70 TAEDIKIKVATVFPDARHeei...SIRGRDMVSG...LPR....T....ITVNSKEV.EEALRES 71 ACERAKRTLSSST---EA......TVEVDSLFDG...TDF....Y....SKITRARF.EELCADL 72 TAEHVKRTVFSEERVKVK......NI--------...LDR....E....IELNVREV.SEAIKPV 73 EAENMKLNHVSMINDNKS......NGSFRMTFAD...KFS....E....REFRSSEV.NRLAKAR 74 QCERTKRTLSSST---QA......TIEIDSLFEG...IDY....S....VSISRARF.EELCMDY 75 TAEKLKIKIGNVYPDIQNlrvekiDIKGTDAVTG...LPR....K....QLVDSMEV.RESLQEP 76 ACERAKRTLSSAA---QT......SIEIDSLYEG...IDF....Y....TSITRARF.EELCQDL 77 HCERAKRVLSSST---QA......TIELDSLYEG...IDY....N....TTISRARF.EELCNEK 78 ACERAKRTLSSSA---QA......SIEIDALYEG...IDF....Y....TTLTKPRF.EELNNDL 79 YAEEIKIRYACALAKLAGa.....GETIKVPTVG...DRP....P....GELSRQAL.AEVVEPR 80 EVEIAKRNLSVVH---ST......QIEIEDIVEG...HNF....S....ETLTRAKF.EELNDDL 81 AAEKAKIELSSTSQTDIN......LPFITADASGa..KHL....N....ITLTRSKF.ETLVNHL 82 EAEKAKHTLSTLP---QV......NIEIENFMDG...EDF....T....ETLTRARF.EEINNDL 83 AAEKAKIELSSTTQTEIN......LPFITADQTGp..KHL....T....MKLTRAKF.EALVDDL 84 EAERAKRTLSVQQ---QD......RIEIENLADG...VDF....S....FTLTRAKF.EELNMDL 85 AAEKAKIELSSTSQTDIN......LPFITADASGa..KHL....N....ITLTRSKF.ETLVNNL 86 ACERAKRTLSSSS---EA......SIEIDSLFEG...IDY....Y....TKVSRARF.EELCGDL 87 AAEKAKIELSSSLQTDIN......LPYLTMDKAGp..KHM....H....LKLTRAKL.EHLVEPL 88 ACERAKRTLSSAA---QT......SIEIDSLYEG...IDF....Y....TSITRARF.EELCQDL 89 AAEKGKKELSSSQQTDIN......PPFITADASGa..KHL....Q....MSITRAEF.ERLCDPL 90 ACERAKRTLSSSS---EA......SIEIDSLFEG...IDY....Y....TKVSRARF.EELCGDL 91 AAEKAKMELSSVMETEINl.....PFIIADASGP...KHL....T....MKLTRARF.EQLVEDL 92 ACERVKRTLSSSA---ST......NIAIDALYEG...FDF....F....SKITRARF.EEMCRDQ 93 ACERAKALSSQT----QT......TIEIDSLFEG...IDF....N....ATITRAKF.EELNIDL 94 EPSRAKVELSSAMETEIQ......LPFITADASGp..KHL....V....MKLTRAKF.EALVEPL 95 AAEKAKIELSGTMSTQINl.....PFITAEPSRP...KHL....E....LTLTRAKFdQDLTKSL 96 ACERAKRTLSSTA---QT......TIEIDSLYEG...IDF....Y....STITRARF.EELNMDL 97 ACERAKRTLSSVT---QT......MVEVDSLYQG...EDF....S....ASITRARF.EEINAVL 98 ------------------......----------...---....P....QEKSRKEL.SVIINSR 99 EAGRLKNVLSANT---EF......FAQIENLIED...IDF....K....LPVTREKL.EQLCEDL 310 320 330 340 350 360 | | | | | | 1 LREIMSK.SKKFFRE.VEAKIVEEG.EIGIPGGVVLTGGGAKIPRINELATEVF.KSP.VRTGCY 2 YDELFTL.VQAELRR.SGY------.EDLIPAGIVLTGGTSKMEGAVELAEEIF.HMP.VRLG-- 3 YDELFTL.IQAELRR.SGY------.EDLVPAGIVLTGGTAKMEGAVELAEEIF.HMP.VRLG-- 4 YTELLNL.VNEEILQ.LQEKLRQQGvKHHLAAGIVLTGGAAQIEGLAACAQRVF.HTQ.VRIG-- 5 YTELLNL.VNEEILQ.LQEKLRQQGvKHHLAAGIVLTGGARQIEGLAACAQRVF.HTQ.VRIG-- 6 IQEIFGV.VLGELQK.SGF-----P.KEVLNAGIVLTGGVSMMTGIVEFAEKIF.DLP.VRTG-- 7 IQEIFGV.VLGELQK.SGF-----P.KEVLNAGIVLTGGVSMMTGIVEFAEKIF.DLP.VRTG-- 8 YNELLHL.INNRILY.VQKKLYKEGrKYQLTGGIVLTGGASTISFLTECAEKIF.QKK.IRIA-- 9 YTELLGV.VKDELDK.LKAELEAKHiKFELIAGVVITGGGAQIEDLKECASNVF.HCQ.VRIA-- 10 VEEILEI.VSEELRS.MGI------.-TDLPGGFVLTGGQAAMPGVMSLAQDVL.QNN.VRVQ-- 11 IEETLEL.IRDRIQR.SGF------.SPIVGKRIVLTGGASQLTGLPEAARRIL.ARN.VRIG-- 12 VSEIYGL.IRDEIDQaLGP------.VELVAQSVVLTGGGAQLPGAVDLARERF.RLP.TRLG-- 13 LREIMSK.SKKFFRE.VEAKIVEEG.EIGIPGGVVLTGGGAKIPRINELATEVF.KSP.VRTGCY 14 IEETLEL.IRDRIQK.SGF------.SPIVGKRVVLTGGASQLTGLPETARRIL.ARN.VRIG-- 15 VEEIVEK.VFKEIKA.RGV-----P.LNQINSGIVVTGGTANLKGIRELIEHMT.GLP.VRIG-- 16 LREIFEM.MKAEILK.RGL------.YNKINGGIVLTGGGALFPGISNLIEEVF.NYP.ARIG-- 17 LREIFEM.MKAEILK.RGL------.YNKINGGIVLTGGGALFPGISNLIEEVF.NYP.ARIG-- 18 VEEILEM.MRDRLNR.SGF------.GHIIGKRVILTGGASQLTGLPEMARNIL.GRN.VRIG-- 19 IKHILEQ.IKQELDR.RRL------.-LDLPGGIVLIGGNAILPGMVELAQEVF.GVR.VKLY-- 20 ALETFKI.IHRSIQD.SGF------.EEHLGGGVVLTGGMALMKGIKELARTHFtNYP.VRLA-- 21 MEQIFNK.AKEALDQ.IEA------.-LELPGGIVLTGGAASLPGVVDLAQEIF.GVN.VKLY-- 22 ALETFKI.IHRSIQD.SGL------.EEHLGGGVVLTGGMALMKGIKELARTHFtNYP.VRLA-- 23 LDHWMDH.IADALKS.LGY------.NGPVGRQVVLTGGGAELKGIADYAQGVL.GRS.VRIG-- 24 MCEVFTI.VRDRLST.VET----QS.GRGIIENIILCGGGAQLTGAVELASAIF.DTPrVHLG-- 25 AEETLMI.LAKILSD.NRY------.ANAIGGGVVLTGGMTKLAGIDELAPATFdNRS.VRLA-- 26 MTQVFNR.VRQDLEH.GHT------.-SETPGGLILVGGTAAMPGVVDLATKIL.GMN.ARLY-- 27 AEEILSM.VKAEYDK.ATK------.GQFEVFRVVITGGGSQLRGLKELSNKIF.AKQ.SRIG-- 28 VEQILRK.SKEVLDE.IDA------.-FELPGGVVLTGGAASIARYCRFRRKRFlEAN.VKLY-- 29 FRSTMEP.VERVLRD.AKI------.DKSSVHEIVLVGGSTRIPRIQKLVSDFFnGKE.PNKS-- 30 VAVIVQA.AKQVLER.TPP---ELS.ADIIDRGVIITGGGALLNGLDQLLAEEL.KVP.VLVA-- 31 VNAIVDA.VKTTLDK.CPP---ELS.GDIMDRGIVLTGGGALLRGLDERLRRET.GMP.IHIA-- 32 VREISSA.LRSVLEE.VKP---DLA.KDIVQNGVVLTGGGALIKGLDKYLSDMV.KLP.VYVG-- 33 VREISSA.LRSVLEE.VKP---DLV.KDIVQNGVVLTGGGALIKGLDKYLSDMV.KLP.VYVG-- 34 VREISSA.LRSVLEE.VKP---DLV.RDIVQNGVVLTGGGALIKGLDKYLSDMV.KLP.VYVG-- 35 FRSTMDP.VERVLRD.AKI------.DKSSVHEIVLVGGSTRIPRIQKLVSDFFnGKE.PNKS-- 36 ITQIVEE.IKRTLAR.TPP---ELA.ADIVERGIVMTGGGSLLKGLPKLISKET.HVP.VILA-- 37 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 38 VEEIFFE.VFDVLQD.LGL------.-TKVNGGFIVTGGSANLLGVKELLSDMV.SEK.VRIH-- 39 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 40 VSTIVEA.VKSTLEK.TPP---ELA.ADIMDRGIVLTGGGALLRNLDKVISEET.KMP.VLIA-- 41 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 42 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 43 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 44 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 45 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 46 VSTIVEA.VKSTLEK.TPP---ELA.ADIMDRGIVLTGGGALLRNLDKVISEET.KMP.VLIA-- 47 AAVIVQA.AKGVLER.TPP---ELS.ADIIDRGVILTGGGALLHGIDMLLAEEL.KVP.VLIA-- 48 FRSTMEP.VEKVLRD.SKI------.DKSSVNEIVLVGGSTRIPKIQKLVSDMFsGRE.PNRS-- 49 FRNTMEP.VEKVLRD.SKI------.DKSSVNEIVLVGGSTRIPRIQKLVSDFF.NGK.EPCK-- 50 FRATLKP.VQKVLED.ADM------.KKTDVHEIVLVGGSTRIPKVQQLIKDYFnGKE.PSRG-- 51 LLHILEA.IRATLED.CPP---ELS.GDIVDRGVILTGGGALLNGIKEWLTEEI.VVP.VHVA-- 52 SKKTMKP.VEQVLKD.GNV------.KKSDIDDIVLVGGSTRIPKVQQLLEDYFdGKK.VSKS-- 53 FKKTMKP.VEQVLKD.GNV------.KKSDIDDIVLVGGSTRIPKVQQLLEEFFdGKK.VSKS-- 54 LKEIADA.LKMVLEM.MPP---DLA.SDIVENGVVLTGGGALIRGLDKYLSEIV.RLP.VYIA-- 55 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 56 FRNSLLP.VEKVLKD.SGI------.DKRSVSEVVLVGGSTRIPKIQQLITDFF.NGK.EPCR-- 57 FRNSLLP.VEKVLKD.SGI------.DKRSVSEVVLVGGSTRIPKIQQLITDFF.NGK.EPCR-- 58 FRNSLLP.VEKVLKD.SGI------.DKRSVSEVVLVGGSTRIPKIQQLITDFF.NGK.EPCR-- 59 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 60 FRGTLEP.VEKSLRD.AKL------.DKGQIHDVVLVGGSTRIPKIQKLLQDFFnGRE.LNKS-- 61 VNAIVDAgSRTTLDK.CPP---ELS.GDIMDRGIVLTGGGALLPGLDERLRRET.GMP.IHIA-- 62 FKKTLKP.VEKVLQD.SGL------.EKKDVDDIVLVGGSTRIPKVQQLLESYFdGKK.ASKG-- 63 FRKTLEP.VEKALRD.AKL------.DKSKIDEVVLVGGSTRVPKIQKLLKDFFnGKE.LNCS-- 64 FRSTLKP.VQKVLED.ADM------.NKKDVDEIVLVGGSTRIPKVQQLVKEFFnGKE.PSRG-- 65 FRSTLQP.VETALRD.AKL------.DKGKIDEVVLVGGSTRIPKVQKLLTDFFnGKE.LNKS-- 66 FRSTLQP.VETALRD.AKL------.DKGKIDEVVLVGGSTRIPKVQKLLTDFFnGKE.LNKS-- 67 VAVIVQA.AKQVLER.TPP---ELS.ADIIDRGVIITGGGALLNGLDQLLAEEL.KVP.------ 68 FRETLEP.VKKVLDD.AKY------.EKSKIDEIVLVGGSTRIPKIQQIIKEFFnGKE.PNRG-- 69 VEEI---.----IEN.AWFQVPNEY.ADKLLGGIILTGGGSNMPNIEKAFRSHT.HIE.------ 70 VAVIVQA.AKQVLER.TPP---ELS.ADIIDRGVIITGGGALLNGLDQLLAEE-.---.------ 71 FRKTLEP.VEKALRD.AKT------.DKGRIDEVVLVGGSTRIPKIQKLLKEFFnGKD.LNCS-- 72 VDQITTE.ISTVVTE.LNG------.--GAPSVVMVVGGGAKVPGFVESLARKL.DLPlDRVSLK 73 MDEITAN.YLNILRL.SGL------.LEDIGAGIILNGGGTKINNYMAAMKKIL.G--.------ 74 FRNSLLP.VEKVLKD.SGI------.DKRSVSEVVLVGGSTRIPKIQQLITDFF.NGK.EPCR-- 75 INVVVDE.VKRTLGA.TPP---ELA.TDIVERGIILTGGGALLKGLNRLLSKET.GVP.VYVA-- 76 FRSTMDP.VERVLRD.AKI------.DKSSVHEIVLVGGSTRIPRIQKLVSDFFnGKE.PNKS-- 77 FRSTLVP.VEKALES.SGL------.DKRSIHEVVLVGGSTRIPKIQSLIKSFF.NGK.EPCR-- 78 FKKTTEC.VEKAVRD.AKM------.EKGEIHEIVLVGGSTRIPKIQKLLEDFFkGKS.LNKS-- 79 YDELFTL.VQAELRR.SGY------.EDLIPAGIVLTGGTSKMEGAVELAEEIF.HMP.VRLG-- 80 FRETLEP.VKKVLDD.AKY------.EKSKIDEIVLVGGSTRIPKIQQIIKEFFnGKE.PNRG-- 81 IERTRNP.CKNCLKD.AGV------.SLKDVDEVLLVGGMTRVPKVQEIVSEIF.GKS.PSKG-- 82 FKKCMGP.VDQVLKD.AGL------.SKSEIDDVVLVGGSTRIPKVQQLVKSFFnGKE.PSKA-- 83 IQKTVEP.CRKALKD.AGV------.TAGEIGEVVLVGGMSRMPKVQEVVKQLF.GKE.PHKG-- 84 FKSTIAP.VKKVLED.SKM------.SKGAIHEVVLVGGSTRIPKVQQLLKEFFnGKE.PSRG-- 85 IERTRNP.CKNCLKD.AGV------.SLKDVDEVLLVGGMTRVPKVQEIVSEIF.GKS.PSKG-- 86 FRNTLEP.VETALRD.AKL------.DKGKIDEVVLVGGSTRIPKIQKLLTDFFnGKE.LNKS-- 87 IKRTIDP.CNKALKD.AEV------.KASDIGEIILVGGMTRMPKVQETVEKIF.GKT.PSKS-- 88 FRSTMDP.VERVVRD.AKI------.DKSSVHEIVLVGGSTRIPRIQKLVSDFFnGKE.PNKS-- 89 FERCREP.VTKALKD.AKL------.DPKEIDEVVLVGGSTRIPKVQELVREMF.GKE.PHKG-- 90 FRNTLEP.VETALRD.AKL------.DKGKIDEVVLVGGSTRIPKIQKLLTDFF.N--.------ 91 LQKSVGP.CKQALSD.AGV------.KPEQIDEVVLVGGSTRIPRVQQIVRDLF.KKE.PHKG-- 92 FERCLEP.VRKVLKD.AEV------.DASAVDDVVLVGGSTRIPRVQQLVQNFF.N--.------ 93 FRGCLEP.VEKVLRD.AKV------.DKGTIHDIVLVGGSSRIPKVQQLLRDFF.NGK.ELCQ-- 94 LKRLMPP.VEQAIKD.AGL------.EPKDIEEIVLVGGSTRIPKVQEMVKGFF.GKE.PNKS-- 95 VDRTRIP.CEKHLRD.AGL------.KASDINEVILVGGGLRIPAVQELVKQVF.GKE.PNKS-- 96 FRKCMEP.VEKCLRD.AKM------.DKSTVHDVVLVGGSTRIPRVQQLLQDFF.NGK.ELCK-- 97 FKSTLEP.VEKVLKD.AKM------.AHEKVDDIVLVGGSTRIPKVQALVSEYFgGRQ.LNKS-- 98 LREIFEM.MKAEILK.RGL------.YNKINGGIVLTGGGALFPGISNLIEEVF.NYP.ARIG-- 99 WPRATKP.LEEALAS.SHL------.SLDVINQVILFGGGTRVPRVQETIKAVI.KQE.LGKN-- 370 380 390 400 | | | | 1 ANSDRPSIINADEVANDPSFAAAFGNV.....FAVSE.....NPYE.......ETPVKSE.NPL. 2 ---VPYSVKGLTDVVRNPIYSTGVGLL.....MYGLQ.....KQSDgmsmsvsGSSYSSD.EPK. 3 ---VPHSVRGLSDVVRNPIYSTGVGLL.....TYGLL.....KQSE.......DLA----.---. 4 ---APLNITGLTDYAQEPYYSTAVGLL.....HYGKE.....SHLN.......GEAEVEK.RVT. 5 ---APLNITGLTDYAQEPYYSTAVGLL.....HYGKE.....SHLN.......GEAEVEK.RVT. 6 ---APQEMGGLSDRVRTPRFSTAIGLL.....HAACKlegnlPQLE.......NGAVQER.EGG. 7 ---APQEMGGLSDRVRTPRFSTAIGLL.....HAACKlegnlPQPE.......NGAVQER.EGG. 8 ---KPLNISGLTDNVTEPHYSTVVGLL.....HYGKE.....FYFD.......DTNQKREiSFI. 9 ---SPLNITGLTDYVNRPQYSTVVGLL.....QYNYS.....NSDD.......DLISGSD.DSE. 10 ----GPNYIGV----RDPQYMTGVGLI.....QFACR.....----.......-------.---. 11 ---RPLGVSGLPAAAKGPAFSTAVGLM.....IYPQV.....ADLE.......THA----.---. 12 ---RPRGIHGLSDIVGDPAHACSVGMV.....LYGI-.....----.......-------.---. 13 ANSDRPSIINADEVANDPSFAAAFGNV.....FAVSE.....NPYE.......ETPVKSE.NPL. 14 ---RPMGVAGLPVAAKGPAFSTACGLM.....IYPQV.....ADIE.......IHA----.---. 15 ---LPQGIVGLREKIENPKYATVCGLLrqaf.VSGTI.....DITE.......STNSNTG.NFF. 16 ---LPMSINGIGEEHIDPKFSSALGLV.....LYKHE.....QQ--.......-------.---. 17 ---LPMSINGIGEEHIDPKFSSALGLV.....LYKHE.....QQ--.......-------.---. 18 ---RPLGISRLPSFAKGATFSSAVGLL.....IYPQL.....VGFE.......KK-----.---. 19 ----VPNQVGI----RNPAFAHVIS--.....-----.....----.......-------.---. 20 TPVEKYNIMGMFEDLKDPRFSVVVGLI.....LYKAG.....GHTN.......YERDS--.---. 21 ----VPNQMGL----RNPVFTNVISIV.....DY---.....----.......-------.---. 22 APVEKYNIMGMFEDLKDPRFSVVVGLI.....LYKAG.....GHTN.......YERDSK-.---. 23 ---RPHGLVGLPDAHSGPAFATLTGLV.....LHAAS.....EPFD.......LRPLSYN.NRIg 24 ---IPGTLGGLAGEYRSPEFAVVLGLI.....LEYTH.....K---.......-------.---. 25 -TARKDLITGFSEIFNDPENTCAIGLC.....LYGAG.....YFTP.......YELDSNE.KL-. 26 ----VPGEMGL----RNPAFAQVISVV.....-----.....----.......-------.---. 27 ---KPEIIAGFTEDYNPAMYSAAIGMLkiha.LKQQK.....ALSH.......IRLDENI.NFF. 28 ----VPNHMGL----RNPVFANVISIV.....EYS--.....----.......-------.---. 29 ---------------INPDEAVAYGAA.....VQAA-.....----.......-------.---. 30 ---------------ENPMDCVAIG--.....-----.....----.......-------.---. 31 ---------------EDPLDSVALG--.....-----.....----.......-------.---. 32 ---------------DEPLLAVAKG--.....-----.....----.......-------.---. 33 ---------------DEPLLAVAKG--.....-----.....----.......-------.---. 34 ---------------DEPLLAVAKG--.....-----.....----.......-------.---. 35 ---------------INPDEAVAYGAA.....VQAA-.....----.......-------.---. 36 ---------------ENPMNCVAIG--.....-----.....----.......-------.---. 37 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 38 ----TPSQMGI----RKPEFSSAISTIsssiaFDELL.....DYVT.......INYHDNE.ETE. 39 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 40 ---------------EDPLDCVAIG--.....-----.....----.......-------.---. 41 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 42 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 43 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 44 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 45 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 46 ---------------EDPLDCVAIG--.....-----.....----.......-------.---. 47 ---------------ENPMHCVAVG--.....-----.....----.......-------.---. 48 ---------------INPDEAVAYGAA.....V----.....----.......-------.---. 49 --------------SINPDEAVAYGAA.....VQ---.....----.......-------.---. 50 ---------------INPDEAVAYGA-.....-----.....----.......-------.---. 51 ---------------QNPLESVAIG--.....-----.....----.......-------.---. 52 ---------------INPAEAVAYGAT.....-----.....----.......-------.---. 53 ---------------INPDEAVAYGAT.....-----.....----.......-------.---. 54 ---------------DEPLLAVAKG--.....-----.....----.......-------.---. 55 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 56 --------------SINPDEAVAYGAA.....-----.....----.......-------.---. 57 --------------SINPDEAVAYGAA.....-----.....----.......-------.---. 58 --------------SINPDEAVAYGAA.....-----.....----.......-------.---. 59 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 60 ---------------INPDEAVAYGAA.....V----.....----.......-------.---. 61 ---------------EDPLDSVALG--.....-----.....----.......-------.---. 62 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 63 ---------------INPDEAVAFGAA.....-----.....----.......-------.---. 64 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 65 ---------------INPDEAVAYGAA.....V----.....----.......-------.---. 66 ---------------INPDEAVAYGAA.....V----.....----.......-------.---. 67 ---------------------------.....-----.....----.......-------.---. 68 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 69 ---------------------------.....-----.....----.......-------.---. 70 ---------------------------.....-----.....----.......-------.---. 71 ---------------INPDEAVAFGAA.....-----.....----.......-------.---. 72 SVESTGLVEDLTGKVKGSEYITPVGIA.....YSAMR.....----.......-------.---. 73 ---------------------------.....-----.....----.......-------.---. 74 --------------SINPDEAVAYGAA.....-----.....----.......-------.---. 75 ---------------DNPLLSVAVGA-.....-----.....----.......-------.---. 76 ---------------INPDEAVAYGAA.....VQAA-.....----.......-------.---. 77 --------------SINPDEAVAYGAA.....VQ---.....----.......-------.---. 78 ---------------INPDEAVAYGAA.....VQ---.....----.......-------.---. 79 ---VPYSVKGLTDVVRNPIYSTGVGLL.....MYGLQ.....KQSDgmsmsvsGSSYSSD.EPK. 80 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 81 ---------------VNPDEAVAMGAA.....L----.....----.......-------.---. 82 ---------------VNPDEAVAHGAA.....VQA--.....----.......-------.---. 83 ---------------VNPDEVVAIGAA.....-----.....----.......-------.---. 84 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 85 ---------------VNPDEAVAMGAA.....L----.....----.......-------.---. 86 ---------------INPDE-------.....-----.....----.......-------.---. 87 ---------------VNPDEAVAMGAA.....I----.....----.......-------.---. 88 ---------------INPDEAVAYGAA.....VQAAI.....----.......-------.---. 89 ---------------VNPDEAV-----.....-----.....----.......-------.---. 90 ---------------------------.....-----.....----.......-------.---. 91 ---------------VNPDEAV-----.....-----.....----.......-------.---. 92 ---------------------------.....-----.....----.......-------.---. 93 --------------SINPDEAVAYGAV.....QAA--.....----.......-------.---. 94 ---------------VNPDEAV-----.....-----.....----.......-------.---. 95 ---------------VNPDEVVAIGAA.....-----.....----.......-------.---. 96 --------------NINPDEAVAYGAA.....VQ---.....----.......-------.---. 97 ---------------INP---------.....-----.....----.......-------.---. 98 ---LPMSINGIGEEHIDPKFSSALGLV.....LYKHE.....QQ--.......-------.---. 99 ---------------LNADESATMGAV.....Y----.....----.......-------.---. 410 | 1 ..KKIFRLFKELME 2 ..APVLERLKRWV- 3 ..------------ 4 ..ASVGSWIKRL-- 5 ..ASVGSWIKRL-- 6 ..GGLLARLKRWIE 7 ..GGLLARLKRWIE 8 ..EKWFQKISNWF- 9 ..GTFFES------ 10 ..------------ 11 ..------------ 12 ..------------ 13 ..KKIFRLFKELME 14 ..------------ 15 ..KNLSERFKKWFE 16 ..------------ 17 ..------------ 18 ..------------ 19 ..------------ 20 ..------------ 21 ..------------ 22 ..------------ 23 sqKSFMG------- 24 ..------------ 25 ..------------ 26 ..------------ 27 ..KKAFDWFKE--- 28 ..------------ 29 ..------------ 30 ..------------ 31 ..------------ 32 ..------------ 33 ..------------ 34 ..------------ 35 ..------------ 36 ..------------ 37 ..------------ 38 ..EDVIDVKDK--- 39 ..------------ 40 ..------------ 41 ..------------ 42 ..------------ 43 ..------------ 44 ..------------ 45 ..------------ 46 ..------------ 47 ..------------ 48 ..------------ 49 ..------------ 50 ..------------ 51 ..------------ 52 ..------------ 53 ..------------ 54 ..------------ 55 ..------------ 56 ..------------ 57 ..------------ 58 ..------------ 59 ..------------ 60 ..------------ 61 ..------------ 62 ..------------ 63 ..------------ 64 ..------------ 65 ..------------ 66 ..------------ 67 ..------------ 68 ..------------ 69 ..------------ 70 ..------------ 71 ..------------ 72 ..------------ 73 ..------------ 74 ..------------ 75 ..------------ 76 ..------------ 77 ..------------ 78 ..------------ 79 ..APVLERLKRWV- 80 ..------------ 81 ..------------ 82 ..------------ 83 ..------------ 84 ..------------ 85 ..------------ 86 ..------------ 87 ..------------ 88 ..------------ 89 ..------------ 90 ..------------ 91 ..------------ 92 ..------------ 93 ..------------ 94 ..------------ 95 ..------------ 96 ..------------ 97 ..------------ 98 ..------------ 99 ..------------