; SAM: prettyalign v3.2 (July 31, 2000) compiled 08/11/00_16:27:51 ; (c) 1992-2000 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequences correspond to the following labels: ; 1 O25177/21-204 ; 2 O25177/21-204 ; 3 gi|7464253|pir||A64573_22:201 ; 4 gi|7464533|pir||B64696_22:201 ; 5 gi|7464994|pir||E71824_21:201 ; 6 O31903/58-212 ; 7 O31903/58-212 ; 8 gi|9630257|ref|NP_046684.1|_58:210 ; 9 gi|7521421|pir||D71289_72:203 ; 10 O83702/72-370 ; 11 O83702/72-370 ; 12 gi|7451688|pir||H71513_82:249 ; 13 O84453/81-249 ; 14 O84453/81-249 ; 15 gi|7190761|gb|AAF39542.1|_83:249 ; 16 gi|3063673|gb|AAC14136.1|_11:176 ; 17 P94659/11-177 ; 18 P94659/11-177 ; 19 Q9Z7Z0/82-250 ; 20 Q9Z7Z0/82-250 ; 21 gi|7451687|pir||D72062_83:248 ; 22 O51269/73-370 ; 23 O51269/73-370 ; 24 gi|7463775|pir||F70131_73:206 ; 25 gi|4101624|gb|AAD01239.1|_73:206 ; 26 gi|4102237|gb|AAD09318.1|_73:206 ; 27 RECJ_ECOLI/67-239 ; 28 RECJ_ECOLI/67-239 ; 29 gi|96357|pir||C39202_69:240 ; 30 gi|2507106|sp|P21893|RECJ_ECOLI_68:239 ; 31 gi|2507107|sp|P39693|RECJ_ERWCH_66:238 ; 32 RECJ_ERWCH/66-238 ; 33 RECJ_ERWCH/66-238 ; 34 gi|9656991|gb|AAF95560.1|_69:241 ; 35 gi|1172895|sp|P45112|RECJ_HAEIN_65:233 ; 36 RECJ_HAEIN/63-233 ; 37 RECJ_HAEIN/63-233 ; 38 gi|7226077|gb|AAF41253.1|_68:237 ; 39 gi|7379749|emb|CAB84317.1|_68:235 ; 40 gi|7453624|gb|AAF62912.1|_68:237 ; 41 gi|7228156|emb|CAB77039.1|_67:236 ; 42 gi|9106065|gb|AAF83920.1|AE003946_11_44:225 ; 43 gi|7462837|pir||F72243_73:231 ; 44 O32044/76-232 ; 45 O32044/76-232 ; 46 gi|7475820|pir||H69980_76:231 ; 47 gi|7470865|pir||S77224_80:244 ; 48 P73518/80-246 ; 49 P73518/80-246 ; 50 gi|6967533|emb|CAB72521.1|_47:204 ; 51 gi|7451682|pir||B71946_42:203 ; 52 O25115/42-203 ; 53 O25115/42-203 ; 54 gi|7451683|pir||D64563_43:203 ; 55 gi|7473679|pir||E75434_3:160 ; 56 gi|7451686|pir||G71656_80:249 ; 57 Q9ZD22/80-250 ; 58 Q9ZD22/80-250 ; 59 O67909/73-229 ; 60 O67909/73-229 ; 61 gi|7451685|pir||A70485_73:229 ; 62 gi|7482966|pir||C69259_26:171 ; 63 O30161/24-173 ; 64 O30161/24-173 ; 65 gi|2842584|sp|Q58387|RECJ_METJA_17:169 ; 66 Y977_METJA/15-169 ; 67 Y977_METJA/15-169 ; 68 gi|7450704|pir||H71224_24:170 ; 69 O57804/23-171 ; 70 O57804/23-171 ; 71 gi|7450703|pir||G75192_25:171 ; 72 O27473/31-174 ; 73 O27473/31-174 ; 74 gi|7450701|pir||E69056_31:173 ; 75 O29559/20-162 ; 76 O29559/20-162 ; 77 gi|7450702|pir||C69337_21:162 ; 78 gi|2833617|sp|Q58241|Y831_METJA_20:167 ; 79 Y831_METJA/19-168 ; 80 Y831_METJA/19-168 ; 81 O26266/1-146 ; 82 O26266/1-146 ; 83 gi|7450700|pir||B69086_2:146 ; 84 O29523/14-162 ; 85 O29523/14-162 ; 86 gi|7450705|pir||G69341_15:161 ; 87 O67552/12-160 ; 88 O67552/12-160 ; 89 gi|7445472|pir||F70440_14:159 ; 90 gi|586814|sp|P37484|YYBT_BACSU_334:500 ; 91 YYBT_BACSU/333-502 ; 92 YYBT_BACSU/333-502 ; 93 O73979/14-165 ; 94 O73979/14-165 ; 95 gi|7518694|pir||B71167_14:164 ; 96 gi|7518105|pir||C75065_14:164 ; 97 O66728/1-143 ; 98 O66728/1-143 ; 99 gi|7520820|pir||D70337_13:143 ; 100 gi|7462978|pir||B72344_4:145 ; 101 gi|7430137|pir||B70177_17:169 ; 102 O51564/17-170 ; 103 O51564/17-170 ; 104 gi|7514584|pir||D71323_38:191 ; 105 O83450/37-192 ; 106 O83450/37-192 ; 107 P71615/29-184 ; 108 P71615/29-184 ; 109 gi|7477397|pir||H70693_35:183 ; 110 gi|7471305|pir||A75470_24:174 ; 111 gi|7462295|pir||G72233_8:156 ; 112 gi|7516499|pir||D72622_12:166 ; 113 gi|2496072|sp|Q58025|PPAC_METJA_4:148 ; 114 gi|8134641|sp|O29502|PPAC_ARCFU_5:161 ; 115 gi|8134645|sp|Q9RRB7|PPAC_DEIRA_4:147 ; 116 gi|8134643|sp|P95765|PPAC_STRGC_3:152 ; 117 gi|7674163|sp|O68579|PPAC_STRMU_3:151 ; 118 gi|586817|sp|P37487|PPAC_BACSU_2:149 ; 119 gi|9656203|gb|AAF94837.1|_2:147 ; 120 O58017/157-321 ; 121 O58017/157-321 ; 122 gi|7448980|pir||H71452_158:319 ; 123 gi|7448979|pir||B75216_158:319 ; 124 YG33_METJA/160-312 ; 125 YG33_METJA/160-312 ; 126 gi|3025197|sp|Q59027|YG33_METJA_162:310 ; 127 gi|7448978|pir||D69503_154:303 ; 128 O28250/152-306 ; 129 O28250/152-306 ; 130 P72962/61-231 ; 131 P72962/61-231 ; 132 gi|7469901|pir||S74940_63:230 ; 133 gi|6899406|gb|AAF30828.1|AE002139_1_16:164 ; 134 gi|2496409|sp|Q49428|Y371_MYCGE_16:167 ; 135 Y371_MYCPN/15-167 ; 136 Y371_MYCPN/15-167 ; 137 gi|2496410|sp|P75229|Y371_MYCPN_17:167 ; 138 O34600/8-159 ; 139 O34600/8-159 ; 140 gi|7430136|pir||F69999_11:159 ; 141 gi|3024962|sp|Q58395|Y988_METJA_6:159 ; 142 Y988_METJA/5-161 ; 143 Y988_METJA/5-161 ; 144 MGPA_MYCPN/17-173 ; 145 MGPA_MYCPN/17-173 ; 146 gi|80899|pir||JS0068_5:89 ; 147 gi|2498554|sp|P75144|MGPA_MYCPN_17:172 ; 148 gi|1346531|sp|P22746|MGPA_MYCGE_55:208 ; 149 gi|80890|pir||JQ0091_7:100 ; 150 MGPA_MYCGE/55-209 ; 151 MGPA_MYCGE/55-209 ; 152 gi|7518174|pir||C75097_3:125 ; 153 gi|7483398|pir||C69286_6:130 ; 154 O29950/1-131 ; 155 O29950/1-131 ; 156 gi|7475203|pir||A69893_4:125 ; 157 O31824/1-143 ; 158 O31824/1-143 ; 159 gi|7464707|pir||D71937_3:132 ; 160 gi|7464457|pir||B64650_4:141 ; 161 O25683/3-150 ; 162 O25683/3-150 ; 163 gi|7450090|pir||H69416_329:496 ; 164 O28932/329-499 ; 165 O28932/329-499 ; 166 gi|7450088|pir||A69202_343:519 ; 167 O26857/343-522 ; 168 O26857/343-522 ; 169 Q58598/358-537 ; 170 Q58598/358-537 ; 171 gi|2128720|pir||E64449_358:534 ; 172 gi|7450091|pir||A75011_350:528 ; 173 gi|7450089|pir||A71141_350:528 ; 174 O58078/350-531 ; 175 O58078/350-531 ; 176 O83781/33-211 ; 177 O83781/33-211 ; 178 gi|7519590|pir||E71279_33:208 10 20 30 40 5 | | | | 1 .......EAKQHRPIVFYTDN--DCDGMLAGSVLMSMCYRL........GiKDFFFFSPLRNAHG 2 .......EAKQHRPIVFYTDN--DCDGMLAGSVLMSMCYRL........GiKDFFFFSPLRNAHG 3 .......-AKQHRPIVFYTDN--DCDGMLAGSVLMSMCYRL........GiKDFFFFSPLRNAHG 4 .......-AKQHRPIVFYTDN--DCDGMLAGSVLMSMCYRL........GiKDFFFFSPLRNAHG 5 .......EVKRHRPIIFYTDN--DCDGMLAGSVLMSMCYRL........GiKDFFFFSPLRNAHG 6 .......HLNNKNKLFVQVDS--DVDGYTSSSIIINYIKKI........C.PKANIHYRIQDGKE 7 .......HLNNKNKLFVQVDS--DVDGYTSSSIIINYIKKI........C.PKANIHYRIQDGKE 8 .......HLNNKNKLFVQVDS--DVDGYTSSSIIINYIKKI........C.PKANIHYRIQDGKE 9 .......AHERKEKVLIFGDR--DADGISATTLLFEALCAF........G.LTVCWRVPVA-DEP 10 .......AHERKEKVLIFGDR--DADGISATTLLFEALCAF........G.LTVCWRVPVA-DEP 11 .......AHERKEKVLIFGDR--DADGISATTLLFEALCAF........G.LTVCWRVPVA-DEP 12 .......-KANNEHVMIYGDG--DVDGITGVTLIVEFLQIL........G.VKTSYCCSGTLFKQ 13 a......-KANNEHVMIYGDG--DVDGITGVTLIVEFLQIL........G.VKTSYCCSGTLFKQ 14 a......-KANNEHVMIYGDG--DVDGITGVTLIVEFLQIL........G.VKTSYCCSGTLFKQ 15 .......--ENNEHVMIYGDG--DVDGITGVTLLVEFLQML........G.VKTSYCCSGTLFKQ 16 .......AKERNEHVMVYGDS--DVDGMTGVALLVEFLRSI........D.MKVSYCFLGALLKH 17 .......AKERNEHVMVYGDS--DVDGMTGVALLVEFLRSI........D.MKVSYCFLGALLKH 18 .......AKERNEHVMVYGDS--DVDGMTGVALLVEFLRSI........D.MKVSYCFLGALLKH 19 a......-RDRKEHVMIYGDS--DVDGMTGVALLVEFLRDI........D.VHVSYFFLGAILKQ 20 a......-RDRKEHVMIYGDS--DVDGMTGVALLVEFLRDI........D.VHVSYFFLGAILKQ 21 .......-RDRKEHVMIYGDS--DVDGMTGVALLVEFLRDI........D.VHVSYFFLGAILKQ 22 .......AIKNNENILIFGDK--DADGITATIIMYETLKDF........G.LNVSYKIPSN-GEF 23 .......AIKNNENILIFGDK--DADGITATIIMYETLKDF........G.LNVSYKIPSN-GEF 24 .......AIKNNENILIFGDK--DADGITATIIMYETLKDF........G.LNVSYKIPSN-GEF 25 .......AIKNNENILIFGDK--DADGITATIIMYETLKDF........G.LNVSYKIPSN-GEF 26 .......AIKNNENILIFGDK--DADGIXATIIMYETLKDF........G.LNVSYXIPSN-GEF 27 a......-FREGTRIIVVGDF--DADGATSTALSVLAMRSL........GcSNIDYLVPNRFEDG 28 a......-FREGTRIIVVGDF--DADGATSTALSVLAMRSL........GcSNIDYLVPNRFEDG 29 .......-FREGTRIIVVGDF--DADGATSTALSVLAMRSL........GcSNIDYLVPNRFEDG 30 .......-FREGTRIIVVGDF--DADGATSTALSVLAMRSL........GcSNIDYLVPNRFEDG 31 .......ALADNRRIVIVGDF--DADRATSTALTVLALRSM........AaREVQYLVPNRFEDG 32 .......ALADNRRIVIVGDF--DADRATSTALTVLALRSM........AaREVQYLVPNRFEDG 33 .......ALADNRRIVIVGDF--DADRATSTALTVLALRSM........AaREVQYLVPNRFEDG 34 .......AIAEQKRIIVVGDF--DADGATSSALSVLALRML........GsRNVDYLVPNRFEDG 35 .......--QPQQKIVIVGDF--DADGATSTALSVLALRQL........GfSDVDYLVPNRFEQG 36 ay.....--QPQQKIVIVGDF--DADGATSTALSVLALRQL........GfSDVDYLVPNRFEQG 37 ay.....--QPQQKIVIVGDF--DADGATSTALSVLALRQL........GfSDVDYLVPNRFEQG 38 .......AVGRKEKILIVADY--DADGATACAVGMSGLAAM........G.AKVDFLVPNRFEHG 39 .......AVERQEKILIVADY--DADGATACAVGLDGLAAM........G.AKVDFLVPNRFEHG 40 .......AVERKEKILIVADY--DADGATACAVGLDGLAAM........G.AKVDFLVPNRFEHG 41 .......AIAAQRRILVVGDF--DCDGATACAVGVRGLRML........GaLDVHHAVPNRMVHG 42 .......-IKANGRILVVGDF--DCDGATACAVAVRGLRLL........GaRNVMHAVPNRMVHG 43 .......-RSKNELVLIHGDY--DVDGITSTVMLKEFLEEN........G.WRVDVYIPHRIEEG 44 .......AISQQEKIMIYGDY--DADGVTSTSVMLHTLQKL........S.AQVDFYIPDRFKEG 45 .......AISQQEKIMIYGDY--DADGVTSTSVMLHTLQKL........S.AQVDFYIPDRFKEG 46 .......AISQQEKIMIYGDY--DADGVTSTSVMLHTLQKL........S.AQVDFYIPDRFKEG 47 .......AMAQKEKVTIWGDF--DADGITSTAVLWEGLGQFfpq.....D.SQLTYTIPNRLRES 48 .......AMAQKEKVTIWGDF--DADGITSTAVLWEGLGQFfpq.....D.SQLTYTIPNRLRES 49 .......AMAQKEKVTIWGDF--DADGITSTAVLWEGLGQFfpq.....D.SQLTYTIPNRLRES 50 .......AVEKNEKVAIVGDY--DVDGIISCVIMAEFFDDI........G.FDYIIRIPNRFKDG 51 .......AMRANTEILVVGDY--DADGVISSAIMAKFFKSL........NyKHVRVAIPNRFMDG 52 a......-MRTNTEILVVGDY--DADGVISSAIMAKFFESL........NyKHVRIAIPNRFMDG 53 a......-MRTNTEILVVGDY--DADGVISSAIMAKFFESL........NyKHVRIAIPNRFMDG 54 .......-MRTNTEILVVGDY--DADGVISSAIMAKFFESL........NyKHVRIAIPNRFMDG 55 .......AVREGKRIRIHGDY--DADGVSATATLVLGLRAI........G.ANVHGFIPHRLNEG 56 .......AIVNSQQICIFADY--DVDGATSAALLKHFLRDL........N.IICDIYVPDRIYEG 57 .......AIVNSQQICIFADY--DVDGATSAALLKHFLRDL........N.IICDIYVPDRIYEG 58 .......AIVNSQQICIFADY--DVDGATSAALLKHFLRDL........N.IICDIYVPDRIYEG 59 .......AVLKKKRIIIYGDY--DVDGITGTAILYRVLKLL........G.AKVYPVLPNR-QTG 60 .......AVLKKKRIIIYGDY--DVDGITGTAILYRVLKLL........G.AKVYPVLPNR-QTG 61 .......AVLKKKRIIIYGDY--DVDGITGTAILYRVLKLL........G.AKVYPVLPNR-QTG 62 .......--YAGGGVTVVHHN--DADGLCSGALLKKLCEYC........G.FEAELICIEK---- 63 rs.....--YAGGGVTVVHHN--DADGLCSGALLKKLCEYC........G.FEAELICIEK---- 64 rs.....--YAGGGVTVVHHN--DADGLCSGALLKKLCEYC........G.FEAELICIEK---- 65 .......--NKNNKILIVTHI--DTDGLTSRAILQKLAERL........N.LDADFMFLKQ---- 66 qn.....--NKNNKILIVTHI--DTDGLTSRAILQKLAERL........N.LDADFMFLKQ---- 67 qn.....--NKNNKILIVTHI--DTDGLTSRAILQKLAERL........N.LDADFMFLKQ---- 68 .......-IELGHTIRIISHR--DADGITSAAILAKALARE........G.AKFHISIVKQ---- 69 .......HIELGHTIRIISHR--DADGITSAAILAKALARE........G.AKFHISIVKQ---- 70 .......HIELGHTIRIISHR--DADGITSAAILAKALARE........G.AKFHISIVKQ---- 71 .......-IELGHTIRIISHR--DADGITSAAIVAKALARE........G.ADFHVSIVKQ---- 72 .......HLERGNIIRIISHN--DADGLSAAGVVARAISSM........N.GQFHISILSRLKKE 73 .......HLERGNIIRIISHN--DADGLSAAGVVARAISSM........N.GQFHISILSRLKKE 74 .......HLERGNIIRIISHN--DADGLSAAGVVARAISSM........N.GQFHISILSRLK-- 75 l......-VARHDFIRIYTHH--DADGISAGAIIAKALLKA........G.KAFHITFLKGLNEP 76 l......-VARHDFIRIYTHH--DADGISAGAIIAKALLKA........G.KAFHITFLKGLNEP 77 .......-VARHDFIRIYTHH--DADGISAGAIIAKALLKA........G.KAFHITFLKGLNEP 78 .......-LNHYGYIRVITHH--DTDGLSSGGILAKMLMRT........N.KLFHLTVVEHLSKE 79 i......-LNHYGYIRVITHH--DTDGLSSGGILAKMLMRT........N.KLFHLTVVEHLSKE 80 i......-LNHYGYIRVITHH--DTDGLSSGGILAKMLMRT........N.KLFHLTVVEHLSKE 81 m......-VESSETVTVYSHT--DCDGITAATVLSKVLERL........D.MDHEVRIININEVP 82 m......-VESSETVTVYSHT--DCDGITAATVLSKVLERL........D.MDHEVRIININEVP 83 .......-VESSETVTVYSHT--DCDGITAATVLSKVLERL........D.MDHEVRIININEVP 84 r......-ILKNEEVLVVTHI--DADGITAGTIAHTSLLRA........G.VESGIRFVKQLDES 85 r......-ILKNEEVLVVTHI--DADGITAGTIAHTSLLRA........G.VESGIRFVKQLDES 86 .......-ILKNEEVLVVTHI--DADGITAGTIAHTSLLRA........G.VESGIRFVKQLDES 87 lk.....--NVKGSILILTHENPDGDSLGSGLALYKFLKKK........G.KEVYIGSKDGVPHF 88 lk.....--NVKGSILILTHENPDGDSLGSGLALYKFLKKK........G.KEVYIGSKDGVPHF 89 .......--NVKGSILILTHENPDGDSLGSGLALYKFLKKK........G.KEVYIGSKDGVPHF 90 .......-VTESSNVIIMGHKFPDMDSIGAAIGILKVAQAN........N.KDGFIVIDPNQIGS 91 i......-VTESSNVIIMGHKFPDMDSIGAAIGILKVAQAN........N.KDGFIVIDPNQIGS 92 i......-VTESSNVIIMGHKFPDMDSIGAAIGILKVAQAN........N.KDGFIVIDPNQIGS 93 l......--NRDEGIILLCHHNADPDSLGSAIAFSNFLLSK........G.FSRIRIGVAQSIAS 94 l......--NRDEGIILLCHHNADPDSLGSAIAFSNFLLSK........G.FSRIRIGVAQSIAS 95 .......-LNRDEGIILLCHHNADPDSLGSAIAFSNFLLSK........G.FSRIRIGVAQSIAS 96 .......-LKRDEGIILLCHHNADPDSLGSAIAFSNFLLDR........G.LRNVRIGVAQSIAS 97 mvcpkvv----------ILSEGADLDSLSAAYGVLK----L........Y.PDAYLLKPKHLSKK 98 mvcpkvv----------ILSEGADLDSLSAAYGVLK----L........Y.PDAYLLKPKHLSKK 99 .......---------------ADLDSLSAAYGVLKL----........Y.PDAYLLKPKHLSKK 100 .......---------ITTHRSPDFDAFASCVAAKKLLD--........-.-DHIIVLPSNPARN 101 .......FIKKYNNFVIIGHKDPDFDCIGSSLALSSFLSRI........G.KNSILLNEGPFIRK 102 .......FIKKYNNFVIIGHKDPDFDCIGSSLALSSFLSRI........G.KNSILLNEGPFIRK 103 .......FIKKYNNFVIIGHKDPDFDCIGSSLALSSFLSRI........G.KNSILLNEGPFIRK 104 .......-IDAHRAFAVVGHEKPDGDCVGSSLALASFLRRI........G.KEVELLSAGPFKRR 105 f......-IDAHRAFAVVGHEKPDGDCVGSSLALASFLRRI........G.KEVELLSAGPFKRR 106 f......-IDAHRAFAVVGHEKPDGDCVGSSLALASFLRRI........G.KEVELLSAGPFKRR 107 llsaa..-----ARVGVVCHVHPDADTIGAGLALALVLDGC........G.KRVEVSFAAPATLP 108 llsaa..-----ARVGVVCHVHPDADTIGAGLALALVLDGC........G.KRVEVSFAAPATLP 109 .......------RVGVVCHVHPDADTIGAGLALALVLDGC........G.KRVEVSFAAPATLP 110 .......--AHPGPIVVLSHENPDGDALGSVLGLSRALRTL........G.K----TVLAPMTVP 111 .......-LSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKL........G.KEVKAAVDYK---- 112 .......---EGEKSAVITHRNADPDAVGAALVVREVLRAL........R.MNPCLYSPEGISRQ 113 .......---------VVGHKNPDTDSIASAIVLAYFL---........-.-DCYPARLGDINPE 114 .......-------VYVVGHKNPDTDSVCSAIAFAYLWNKWkeg12mkiE.AEAKPVIQGDVNPE 115 .......---------VFGHLNPDTDAISAAMVYARLLTRQ........G.TEAQAYRLGEPNFE 116 .......------KILVFGHQNPDSDAIGSSYAFAYLAREAy.......G.LDTEAVALGEPNEE 117 .......------KILVFGHQNPDSDAIGSSMAYAYLKRQL........G.VDAQAVALGNPNEE 118 .......-----EKILIFGHQNPDTDTICSAIAYADLKNKL........G.FNAEPVRLGQVNGE 119 .......-------ILVVGHKNPDSDSICSALVAAELLKAR........G.LEAKAVRQGEINRE 120 i......-KEKTDTLLIVMHDNPDPDCMASASALAVIAQSI........G.LKTQIVYGGDITHH 121 i......-KEKTDTLLIVMHDNPDPDCMASASALAVIAQSI........G.LKTQIVYGGDITHH 122 .......-KEKTDTLLIVMHDNPDPDCMASASALAVIAQSI........G.LKTQIVYGGDITHH 123 .......-KERTDSLLIVMHDNPDPDSMASASALAVIAQSV........G.LRPQIVYGGDITHH 124 ee.....--EKKAPLLILTHINPDPDAIASAMALKTLAERW........G.VDSDIAYGGNIGYD 125 ee.....--EKKAPLLILTHINPDPDAIASAMALKTLAERW........G.VDSDIAYGGNIGYD 126 .......--EKKAPLLILTHINPDPDAIASAMALKTLAERW........G.VDSDIAYGGNIGYD 127 .......--LRGKRLGIFTHDNPDPDSMSSAYALREIAKQF........D.VIADILYYGEILHQ 128 e......-SLRGKRLGIFTHDNPDPDSMSSAYALREIAKQF........D.VIADILYYGEILHQ 129 e......-SLRGKRLGIFTHDNPDPDSMSSAYALREIAKQF........D.VIADILYYGEILHQ 130 gh.....---QGQRLILVIQDFPDPDALSSAWAFQLIAAQY........E.IQCDIVYAGTLSHQ 131 gh.....---QGQRLILVIQDFPDPDALSSAWAFQLIAAQY........E.IQCDIVYAGTLSHQ 132 .......---QGQRLILVIQDFPDPDALSSAWAFQLIAAQY........E.IQCDIVYAGTLSHQ 133 .......----FNKITIFVHTNPDCDALGSAFALARILKLNtf......G.TRVKIVGVNALNPN 134 .......-VKQFDKFSLFVHVNPDFDAFGSAFAFKTFLNTF........F.SEKKAYVMGS--YN 135 kl.....--KTFDNFSLYVHVNPDFDAFGAAFAFKAFLAVY........F.PHKKAYVMGS--HN 136 kl.....--KTFDNFSLYVHVNPDFDAFGAAFAFKAFLAVY........F.PHKKAYVMGS--HN 137 .......--KTFDNFSLYVHVNPDFDAFGAAFAFKAFLAVY........F.PHKKAYVMGS--HN 138 ti.....--SLYDTIILHRHVRPDPDAYGSQCGLTEILRET........Y.PEKNIFAVGTPEPS 139 ti.....--SLYDTIILHRHVRPDPDAYGSQCGLTEILRET........Y.PEKNIFAVGTPEPS 140 .......---LYDTIILHRHVRPDPDAYGSQCGLTEILRET........Y.PEKNIFAVGTPEPS 141 .......-YLKRDEVLFLCHHNADPDAVGSCVALKYLASQL........N.PNGKFRISADSVSK 142 e......-YLKRDEVLFLCHHNADPDAVGSCVALKYLASQL........N.PNGKFRISADSVSK 143 e......-YLKRDEVLFLCHHNADPDAVGSCVALKYLASQL........N.PNGKFRISADSVSK 144 .......AIQAHDKIVIFHHIRPDGDCLGAQHGLARLIQTN........F.PHKQVFCVGD--PK 145 .......AIQAHDKIVIFHHIRPDGDCLGAQHGLARLIQTN........F.PHKQVFCVGD--PK 146 .......----------------------------------........-.-------------- 147 .......AIQAHDKIVIFHHIRPDGDCLGAQHGLARLIQTN........F.PHKQVFCVGD--PK 148 .......AIKQFDKIVIFHHVRPDGDCLGAQQGLFHLIKAN........F.KNKEVKCVGN--NN 149 .......----------------------------------........-.-------------- 150 .......AIKQFDKIVIFHHVRPDGDCLGAQQGLFHLIKAN........F.KNKEVKCVGN--NN 151 .......AIKQFDKIVIFHHVRPDGDCLGAQQGLFHLIKAN........F.KNKEVKCVGN--NN 152 .......--------LIIHHW--DTDGITSAALLMKKLG--........-.-------------- 153 .......--------LIIHHW--DTDGITSAALLIKALELD........E.FRNMSPPIGE---- 154 mismn..--------LIIHHW--DTDGITSAALLIKALELD........E.FRNMSPPIGE---- 155 mismn..--------LIIHHW--DTDGITSAALLIKALELD........E.FRNMSPPIGE---- 156 .......---------LYSHN--DLDGVGCGIVAKLA---F........G.KDVEIRYNSV--NG 157 myh....---------LYSHN--DLDGVGCGIVAKLA---F........G.KDVEIRYNSV--NG 158 myh....---------LYSHN--DLDGVGCGIVAKLA---F........G.KDVEIRYNSV--NG 159 .......-------VYHLSHI--DLDGYACQLVSKQFFKNI........Q.-----CYNANYGRE 160 .......-------VYHLSHI--DLDGYACQLVSKQFFKNI........Q.-----CYNANYGRE 161 q......-------VYHLSHI--DLDGYACQLVSKQFFKNI........Q.-----CYNANYGRE 162 q......-------VYHLSHI--DLDGYACQLVSKQFFKNI........Q.-----CYNANYGRE 163 .......AIYESRPVIIRHHW--DADGTCGGVALEKALTDLvervhs..D.SEAKYYLVKR--RV 164 .......AIYESRPVIIRHHW--DADGTCGGVALEKALTDLvervhs..D.SEAKYYLVKR--RV 165 .......AIYESRPVIIRHHW--DADGTCGGVALEKALTDLvervhs..D.SEAKYYLVKR--RV 166 .......AVYDGRSILVRHHA--DADGICAGVAIEKAVLPLlrdlnp..S.TDAEWHYFKR--AP 167 .......AVYDGRSILVRHHA--DADGICAGVAIEKAVLPLlrdlnp..S.TDAEWHYFKR--AP 168 .......AVYDGRSILVRHHA--DADGICAGVAIEKAVLPLlrdlnp..S.TDAEWHYFKR--AP 169 .......AVLDGRPIIIRHHA--DTDGYCGGIALEKAILPIidkfai..D.VDAIWHFFKR--RP 170 .......AVLDGRPIIIRHHA--DTDGYCGGIALEKAILPIidkfai..D.VDAIWHFFKR--RP 171 .......AVLDGRPIIIRHHA--DTDGYCGGIALEKAILPIidkfai..D.VDAIWHFFKR--RP 172 .......AIFEGRPIIIRHHA--DTDGYTAGVALETAIVPLieqvap..D.PDARWHLFKR--RP 173 .......AIFEGRPIILRHHA--DTDGYTAGVALETAIVPLieevap..D.PDARWHLFKR--RP 174 .......AIFEGRPIILRHHA--DTDGYTAGVALETAIVPLieevap..D.PDARWHLFKR--RP 175 .......AIFEGRPIILRHHA--DTDGYTAGVALETAIVPLieevap..D.PDARWHLFKR--RP 176 .......EIAIHGSFLLLGHEHPDEDCIASLVAFALLLTRC........N.KRVEICCQGPIRVQ 177 .......EIAIHGSFLLLGHEHPDEDCIASLVAFALLLTRC........N.KRVEICCQGPIRVQ 178 .......EIAIHGSFLLLGHEHPDEDCIASLVAFALLLTRC........N.KRVEICCQGPIRVQ 0 60 70 80 90 | | | | | 1 YGFTDLAL........NDLLsqp9fnpkTNQLVRLDCIK...NQFQKNPLL.FSADL...GADLa 2 YGFTDLAL........NDLLsqp9fnpkTNQLVRLDCIK...NQFQKNPLL.FSADL...GADLa 3 YGFTDLALndl9qpciFNPK........TNQLVRLDCIK...NQFQKNPLL.FSADL...GADLa 4 YGFTDLALndl9qpciFNPK........TNQLVRLDCIK...NQFQKNPLL.FSADL...GADLa 5 YGFTDLALndl9qlciFNPK........TNQLVRLDYIK...NQFQKTPLL.FSADL...GADLv 6 HGIF----........----........---------ID...TIPDDVDLV.IIPDA...GS--. 7 HGIF----........----........---------ID...TIPDDVDLV.IIPDA...GS--. 8 HGIF----........----........---------ID...TIPDDVDLV.IIPDA...GS--. 9 YGLS----........----........-----CNAVDE...HAAAGGTLI.VTVDC...GI--. 10 YGLS----........----........-----CNAVDE...HAAAGGTLI.VTVDC...GI--. 11 YGLS----........----........-----CNAVDE...HAAAGGTLI.VTVDC...GI--. 12 HGET----........----........-----ASLISQ...MLQDGISLL.ITVDC...GI--. 13 HGET----........----........-----ASLISQ...MLQDGISLL.ITVDC...GI--. 14 HGET----........----........-----ASLISQ...MLQDGISLL.ITVDC...GI--. 15 HGEI----........----........-----TSLISQ...MLQDGVSLL.ITVDC...GI--. 16 YGEP----........----........-----SSLIAK...MKEEKVTLL.ITVDC...GI--. 17 YGEP----........----........-----SSLIAK...MKEEKVTLL.ITVDC...GI--. 18 YGEP----........----........-----SSLIAK...MKEEKVTLL.ITVDC...GI--. 19 HGET----........----........-----STLIAK...LKEEGITLL.ITVDC...GI--. 20 HGET----........----........-----STLIAK...LKEEGITLL.ITVDC...GI--. 21 HGET----........----........-----STLIAK...LKEEGITLL.ITVDC...GI--. 22 YGLS----........----........-----NELINT...ALEKKISLI.ITVDN...GI--. 23 YGLS----........----........-----NELINT...ALEKKISLI.ITVDN...GI--. 24 YGLS----........----........-----NELINT...ALEKKISLI.ITVDN...GI--. 25 YGLS----........----........-----NELINT...ALEKKISLI.ITVDN...GI--. 26 YGLS----........----........-----NELINT...ALEKKISLI.ITVDN...GI--. 27 YGLS----........----........-----PEVVDQ...AHARGAQLI.VTVDN...GI--. 28 YGLS----........----........-----PEVVDQ...AHARGAQLI.VTVDN...GI--. 29 YGLS----........----........-----PEVVDQ...AHARGAQLI.VTVDN...GI--. 30 YGLS----........----........-----PEVVDQ...AHARGAQLI.VTVDN...GI--. 31 YGLS----........----........-----PEVVAQ...APAKGAELI.VTVDN...GI--. 32 YGLS----........----........-----PEVVAQ...APAKGAELI.VTVDN...GI--. 33 YGLS----........----........-----PEVVAQ...APAKGAELI.VTVDN...GI--. 34 YGLS----........----........-----PEVVDQ...AIERGAEMI.MTVDN...GV--. 35 YGLS----........----........-----IPVAEM...AIEKGVQLL.MTVDN...GV--. 36 YGLS----........----........-----IPVAEM...AIEKGVQLL.MTVDN...GV--. 37 YGLS----........----........-----IPVAEM...AIEKGVQLL.MTVDN...GV--. 38 YGLT----........----........-----PELAEI...AAAQGVDLL.ITVDN...GI--. 39 YGLT----........----........-----PELAEI...AAAQGVDLL.ITVDN...GI--. 40 YGLT----........----........-----PELAEI...AAAQGVDLL.ITVDN...GI--. 41 YGLS----........----........-----PALVDE...LAALQPDLL.VTVDH...GI--. 42 YGLS----........----........-----SALVEE...LAPLQPALL.VTVDH...GI--. 43 YGIQ----........----........-----PENIST...FKENNVSCL.VTVDC...GI--. 44 YGPN----........----........-----EQAFRS...IKERGFSLI.ITVDT...GI--. 45 YGPN----........----........-----EQAFRS...IKERGFSLI.ITVDT...GI--. 46 YGPN----........----........-----EQAFRS...IKERGFSLI.ITVDT...GI--. 47 HGLN----........----........-----RPGLER...LATQGTKLI.VTCDT...GS--. 48 HGLNRPGL........ERL-........-----------...-ATQGTKLI.VTCDT...GS--. 49 HGLNRPGL........ERL-........-----------...-ATQGTKLI.VTCDT...GS--. 50 YGLN----........----........-----AEIINE...---LDVNLI.ITVDN...GI--. 51 YGISKKFL........EKH-........-----------...----HAPLI.ITVDN...GI--. 52 YGISKKFL........EKH-........-----------...----HAPLI.ITVDN...GI--. 53 YGISKKFL........EKH-........-----------...----HAPLI.ITVDN...GI--. 54 YGISKKFL........EKH-........-----------...----HAPLI.ITVDN...GI--. 55 YGIH----........----........------PDRVP...EHAAAADLV.VTVDC...GV--. 56 YGPT----........----........-----PLAMQK...IKGNGTELL.ITVDC...GA--. 57 YGPT----........----........-----PLAMQK...IKGNGTELL.ITVDC...GA--. 58 YGPT----........----........-----PLAMQK...IKGNGTELL.ITVDC...GA--. 59 YGLN----........----........------KELMS...IFEKYGDFL.ITVDN...GT--. 60 YGLN----........----........------KELMS...IFEKYGDFL.ITVDN...GT--. 61 YGLN----........----........------KELMS...IFEKYGDFL.ITVDN...GT--. 62 --------........----........---VYPAVVEK...IHSSRDGMI.IYTDL...GG--. 63 --------........----........---VYPAVVEK...IHSSRDGMI.IYTDL...GG--. 64 --------........----........---VYPAVVEK...IHSSRDGMI.IYTDL...GG--. 65 --------........----........---ITIETIND...IPFKDYDLI.IFADL...GSGQl 66 --------........----........---ITIETIND...IPFKDYDLI.IFADL...GSGQl 67 --------........----........---ITIETIND...IPFKDYDLI.IFADL...GSGQl 68 --------........----........---VSEELVRQ...LKDEEYKII.IFSDL...GSGS. 69 --------........----........---VSEELVRQ...LKDEEYKII.IFSDL...GSGS. 70 --------........----........---VSEELVRQ...LKDEEYKII.IFSDL...GSGS. 71 --------........----........---VSEDLVRQ...LKDEDYKVF.IFSDL...GSGS. 72 F-------........----........--------IKK...LSGEKYSLF.FFCDM...GS--. 73 F-------........----........--------IKK...LSGEKYSLF.FFCDM...GS--. 74 --------........----........-----KEFIKK...LSGEKYSLF.FFCDM...GS--. 75 FEYE----........----........-----------...----QGELL.LFADM...GS--. 76 FEYE----........----........-----------...----QGELL.LFADM...GS--. 77 FEYE----........----........-----------...----QGELL.LFADM...GS--. 78 VIEKLAKE........NEV-........-----------...----NKPLF.IFADM...GS--. 79 VIEKLAKE........NEV-........-----------...----NKPLF.IFADM...GS--. 80 VIEKLAKE........NEV-........-----------...----NKPLF.IFADM...GS--. 81 EVEL----........----........-----------...----SSDLT.IFSDL...GS--. 82 EVEL----........----........-----------...----SSDLT.IFSDL...GS--. 83 EVEL----........----........-----------...----SSDLT.IFSDL...GS--. 84 EIEAIKD-........----........-----------...----ENTFV.WFTDI...GS--. 85 EIEAIKD-........----........-----------...----ENTFV.WFTDI...GS--. 86 EIEAIKD-........----........-----------...----ENTFV.WFTDI...GS--. 87 LDFL----........----........---PGVEDVIN...PDGKFYDVG.IVVDA...SG--. 88 LDFL----........----........---PGVEDVIN...PDGKFYDVG.IVVDA...SG--. 89 LDFL----........----........---PGVEDVIN...PDGKFYDVG.IVVDA...SGFY. 90 SVQRLIGE........IKKY........EELWSRFITPEeamEISNDDTLL.VIVDT...HK--. 91 SVQRLIGE........IKKY........EELWSRFITPEeamEISNDDTLL.VIVDT...HK--. 92 SVQRLIGE........IKKY........EELWSRFITPEeamEISNDDTLL.VIVDT...HK--. 93 YSRRLVAL........SRVP........IEKDPVI----...----KENVI.FIFDT...SS--. 94 YSRRLVAL........SRVP........IEKDPVI----...----KENVI.FIFDT...SS--. 95 YSRRLVAL........SRVP........IEKDPVI----...----KENVI.FIFDT...SS--. 96 YSRRLLKF........SRV-........------PIERN...PKI-SERVV.FIFDT...SS-L. 97 AGEVFKKY........RDK-........------FRVIE...DLPDCFE-L.VLVDT...HF--. 98 AGEVFKKY........RDK-........------FRVIE...DLPDCFE-L.VLVDT...HF--. 99 AGEVFKKY........RDK-........---FRVIEDLP...----DCFEL.VLVDT...HFLP. 100 LSDFLK--........---V........YSDRFEFVWDH...EFEGEITEL.VIVDA...PS-L. 101 EIVPFKD-........----........---KFLSEWPN...IEISEYS-V.IILDC...SI-L. 102 EIVPFKD-........----........---KFLSEWPN...IEISEYS-V.IILDC...SI-L. 103 EIVPFKD-........----........---KFLSEWPN...IEISEYS-V.IILDC...SI-L. 104 EIAA----........---Y........ATLFRPSLSAQ...IRPSDQTAV.IVVDC...SE-L. 105 EIAAYATL........FR--........-----PSLSAQ...IRPSDQTAV.IVVDC...SE-L. 106 EIAAYATL........FR--........-----PSLSAQ...IRPSDQTAV.IVVDC...SE-L. 107 ESLRSLPG........CHL-........------LVRPE...VMRRDVDLV.VTVDI...PS-V. 108 ESLRSLPG........CHL-........------LVRPE...VMRRDVDLV.VTVDI...PS-V. 109 ESLR----........---S........LPGCHLLVRPE...VMRRDVDLV.VTVDI...PS-V. 110 HYLS----........---F........LPQPGELTAPL...ESWPQGALA.AVLDV...DNND. 111 -------I........PYVF........EKFPYIDKIEE...NPNFDPELL.VVVDA...SSPD. 112 SKRL----........LEAV........GEEFGPLCSPD...----ENPLIaVVVDA...ANLS. 113 TEFVLRK-........----........---FGVMEPEL...IESAKGKEI.ILVDH...SEKS. 114 TKYVLEK-........----........FGFEVPEIMTN...G---EGKKV.ALVDH...SEKA. 115 TAYVLREL........----........-GLEAPPLLTE...LPAG--SKV.ALVDH...NESA. 116 TAFV-LD-........---Y........FGVAAPRVITS...AKAEGAEQV.ILTDH...NEFQ. 117 TAFV-LD-........---Y........FGIQAPPVVKS...AQAEGAKQV.ILTDH...NEFQ. 118 TQYA-LDY........FK--........---QESPRLVE...TAANEVNGV.ILVDH...NERQ. 119 TQHI-LN-........---V........AGVEQPELRTS...VAGEQVWLV.DYTDL...A---. 120 QNRAMVNV........LGME........FRKVSR---GS...YEIKRHKAI.AIVDA...QP--. 121 QNRAMVNV........LGME........FRKVSR---GS...YEIKRHKAI.AIVDA...QP--. 122 QNRAMVNV........LGME........FR---KVSRGS...YEIKRHKAI.AIVDA...QP--. 123 QNRAMVNV........LGME........---FKKVLRGS...YEIKRYDAI.AIVDA...QP--. 124 ENKAMINL........LGI-........----KLLNVED...IDLDNYCVI.AVIDT...ST--. 125 ENKAMINL........LGI-........----KLLNVED...IDLDNYCVI.AVIDT...ST--. 126 ENKAMINL........LG--........---IKLLNVED...IDLDNYCVI.AVIDT...ST-S. 127 KNRAMVNL........LE--........---IPMIRAPE...VDLSHYDAF.AIVDS...SG--. 128 KNRAMVNL........LEI-........----PMIRAPE...VDLSHYDAF.AIVDS...SG--. 129 KNRAMVNL........LEI-........----PMIRAPE...VDLSHYDAF.AIVDS...SG--. 130 ENIALVKL........TGLP........AKRWGPQMLKD...IDLSDYQGC.VLVDS...QGTN. 131 ENIALVKL........TGLP........AKRWGPQMLKD...IDLSDYQGC.VLVDS...QGTN. 132 ENIALVKL........TGLP........AKRWGPQMLKD...IDLSDYQGC.VLVDS...QGTN. 133 DFKNFFT-........----........---FDPNEVDD...EFIKD-SIA.FIVDT...A---. 134 INADGREL........FPF-........-----EQTDIN...DDFVKESLA.IIFDT...S---. 135 IKADGKDL........FPF-........-----EAAPID...DAFVKNSLA.IIFDT...S---. 136 IKADGKDL........FPF-........-----EAAPID...DAFVKNSLA.IIFDT...S---. 137 IKADGKDL........FPF-........-----EAAPID...DAFVKNSLA.IIFDT...S---. 138 LSFL----........----........----YSLDEVD...NETYEGALV.IVCDT...A---. 139 LSFL----........----........----YSLDEVD...NETYEGALV.IVCDT...A---. 140 LSFL----........----........----YSLDEVD...NETYEGALV.IVCDT...A---. 141 LSRN----........---I........LNEIGERVDIE...IYPKLPETV.FIVDT...AS--. 142 LSRNILNE........IG--........-----ERVDIE...IYPKLPETV.FIVDT...AS--. 143 LSRNILNE........IG--........-----ERVDIE...IYPKLPETV.FIVDT...AS--. 144 HNFPWLEM........VFTP........KEQITPELM--...----QQALA.VIVDA...NYKE. 145 HNFPWLEM........VFTP........KEQITPELM--...----QQALA.VIVDA...NYKE. 146 --------........----........-----------...-------LA.VIVDA...NYKE. 147 HNFPWLEM........VFTP........KEQITPELM--...----QQALA.VIVDA...NYKE. 148 NLFSFINM........T---........-----FTNQID...ESFLKEALA.IVVDA...NYKN. 149 --------........----........---------ID...ESFLKEALA.IVVDA...NYKN. 150 NLFSFINM........TF--........------TNQID...ESFLKEALA.IVVDA...NYKN. 151 NLFSFINM........TF--........------TNQID...ESFLKEALA.IVVDA...NYKN. 152 --EDFENL........TG-P........IGEFRFDDRIW...KEIERAEEI.YVVDF...NV--. 153 --------........----........---FRFDDRIR...KAIEHAERV.YILDL...NLPY. 154 --------........----........---FRFDDRIR...KAIEHAERV.YILDL...NLPY. 155 --------........----........---FRFDDRIR...KAIEHAERV.YILDL...NLPY. 156 LNAQ----........----........---VQYFLEKA...KESNRQDAL.FITDL...AVNE. 157 LNAQ----........----........---VQYFLEKA...KESNRQDAL.FITDL...AVNE. 158 LNAQ----........----........---VQYFLEKA...KESNRQDAL.FITDL...AVNE. 159 VSARIYEI........LNA-........---------IA...QSKESEFLI.LVSDL...NLNL. 160 VSARIYEI........LNA-........---------IA...QSKESEFLI.LVSDL...NLNL. 161 VSARIYEI........LNA-........---------IA...QSKESEFLI.LVSDL...NLNL. 162 VSARIYEI........LNA-........---------IA...QSKESEFLI.LVSDL...NLNL. 163 SRAPFYEL........EDVV........RDLDESLEDAE...RHGDKIPLV.VLVDN...GSGL. 164 SRAPFYEL........EDVV........RDLDESLEDAE...RHGDKIPLV.VLVDN...GSGL. 165 SRAPFYEL........EDVV........RDLDESLEDAE...RHGDKIPLV.VLVDN...GSGL. 166 SKAPFYEL........EDVV........KDLSYALEDLE...RHGQKLPLL.VLLDN...GSTE. 167 SKAPFYEL........EDVV........KDLSYALEDLE...RHGQKLPLL.VLLDN...GSTE. 168 SKAPFYEL........EDVV........KDLSYALEDLE...RHGQKLPLL.VLLDN...GSTE. 169 SKAPFYEL........EDVT........KDLVFSIEDAL...KFGQKLPLI.VLIDN...GSTD. 170 SKAPFYEL........EDVT........KDLVFSIEDAL...KFGQKLPLI.VLIDN...GSTD. 171 SKAPFYEL........EDVT........KDLVFSIEDAL...KFGQKLPLI.VLIDN...GSTD. 172 SRAPFYEL........EDVL........KDIIFMMEDHQ...RFGDELPLI.VIVDN...GGTS. 173 SRAPFYEL........EDVL........KDIIFMMEDHM...RFGDELPLV.VIVDN...GGTT. 174 SRAPFYEL........EDVL........KDIIFMMEDHM...RFGDELPLV.VIVDN...GGTT. 175 SRAPFYEL........EDVL........KDIIFMMEDHM...RFGDELPLV.VIVDN...GGTT. 176 ISFL---I........DICL........YNGIAVHLDTQ...TVPRMPDAL.VILDTpnpGMIY. 177 ISFL---I........DICL........YNGIAVHLDTQ...TVPRMPDAL.VILDTpnpGMIY. 178 ISFL---I........DICL........YNGIAVHLDTQ...TVPRMPDAL.VILDTpnpGMIY. 100 110 120 130 14 | | | | 1 ...A......NTELQEILLEHFEQC.IITDHH.KSFE-VD....WIDENKIAYINLND---.-EK 2 ...A......NTELQEILLEHFEQC.IITDHH.KSFE-VD....WIDENKIAYINLND---.-EK 3 ...A......NTELQEILLEHFEQC.IITDHH.KSFE-VD....WIDENKIAYINLND---.-EK 4 ...A......NTELQEILLEHFEQC.IITDHH.KSFE-VD....WIDENKIAYINLND---.-EK 5 ...S......NIELQKILLERFEQC.IITDHH.KSFE-VD....WIDKNKIAYINLND---.-EK 6 ...S......QFEEHEALNKRGTEI.IVIDHH.ECER---....--VSEHAIVVNNQL---.--S 7 ...S......QFEEHEALNKRGTEI.IVIDHH.ECER---....--VSEHAIVVNNQL---.--S 8 ...S......QFEEHEALNKRGTEI.IVIDHH.ECER---....--VSEHAIVVNNQL---.--S 9 ...S......NRAEIAYARHRGIDV.LVIDHH.AAPE---....--TLPDAIIINAKV---.-PG 10 ...S......NRAEIAYARHRGIDV.LVIDHH.AAPE---....--TLPDAIIINAKV---.-PG 11 ...S......NRAEIAYARHRGIDV.LVIDHH.AAPE---....--TLPDAIIINAKV---.-PG 12 ...T......AGKEVHAINKQGIDV.IVTDHH.MPTG---....-KLPHCVAMLNPKL---.-DK 13 ...T......AGKEVHAINKQGIDV.IVTDHH.MPTG---....-KLPHCVAMLNPKL---.-DK 14 ...T......AGKEVHAINKQGIDV.IVTDHH.MPTG---....-KLPHCVAMLNPKL---.-DK 15 ...T......AGREVRSINKQGIDV.IVTDHH.TPTG---....-KLPHCIATLNPKL---.-DK 16 ...T......AGKEVSDINKQGIDV.IITDHH.MPTG---....-KIPHCIATLNPKL---.-RD 17 ...T......AGKEVSDINKQGIDV.IITDHH.MPTG---....-KIPHCIATLNPKL---.-RD 18 ...T......AGKEVSDINKQGIDV.IITDHH.MPTG---....-KIPHCIATLNPKL---.-RD 19 ...T......AGKEVSDITRQGIDV.IITDHH.MPTG---....-KIPHCVATLNPKL---.-RD 20 ...T......AGKEVSDITRQGIDV.IITDHH.MPTG---....-KIPHCVATLNPKL---.-RD 21 ...T......AGKEVSDITRQGIDV.IITDHH.MPTG---....-KIPHCVATLNPKL---.-RD 22 ...S......SIEEINYANSKGIEI.IITDHH.LPGE---....-NFKTENIVINPHL---.-KD 23 ...S......SIEEINYANSKGIEI.IITDHH.LPGE---....-NFKTENIVINPHL---.-KD 24 ...S......SIEEINYANSKGIEI.IITDHH.LPGE---....-NFKTENIVINPHL---.-KD 25 ...S......SIEEINYANSKGIEI.IITDHH.LPGE---....-NFKTENIVINPHL---.-KD 26 ...S......SIEEINYANSKGIEI.IITDHH.LPGE---....-NFKTENIVINPHL---.-KD 27 ...S......SHAGVEHARSLGIPV.IVTDHH.LPGD---....-TLPAAEAIINPNL---.-RD 28 ...S......SHAGVEHARSLGIPV.IVTDHH.LPGD---....-TLPAAEAIINPNL---.-RD 29 ...S......SHAGVEHARSLGIPV.IVTDHH.LPGD---....-TLPAAEAIINPNL---.-RD 30 ...S......SHAGVEHARSLGIPV.IVTDHH.LPGD---....-TLPAAEAIINPNL---.-RD 31 ...S......SHAGVDDAHRRGIAV.VVTDHH.LPGE---....-TLPAAEAMINPNL---.-SD 32 ...S......SHAGVDDAHRRGIAV.VVTDHH.LPGE---....-TLPAAEAMINPNL---.-SD 33 ...S......SHAGVDDAHRRGIAV.VVTDHH.LPGE---....-TLPAAEAMINPNL---.-SD 34 ...S......SLEGVRYAKQKGLQV.VVTDHH.LPGQ---....-ELPEVDAMVNPNL---.-QQ 35 ...S......SFDGVAFLKEKGIRV.LVTDHH.LPPE---....-TLPPADAIVNPNL---.-SQ 36 ...S......SFDGVAFLKEKGIRV.LVTDHH.LPPE---....-TLPPADAIVNPNL---.-SQ 37 ...S......SFDGVAFLKEKGIRV.LVTDHH.LPPE---....-TLPPADAIVNPNL---.-SQ 38 ...A......SIAGVARAQALGLDV.IVTDHH.LPAE---....--TVPDCIIVNPNQ---.-KG 39 ...A......SIAGVARAQALGLDV.IVTDHH.LPAE---....--TVPDCIIVNPNQ---.-KG 40 ...A......SIAGVARAQALGLDV.IVTDHH.LPAD---....--TVPDCIIVNPNQ---.-KG 41 ...A......CHAGVAAAKARGWTV.LVTDHH.LPGE---....-VLPPADAIVDPNL---.-VQ 42 ...A......CHAGVAAAKARGWQV.LVTDHH.LPGE---....-ILPPADVIVNPNL---.-PG 43 ...T......ALDSVALAKKFGMKV.IVTDHH.EVNG---....-DLPPADAIVNPKV---.-PG 44 ...A......AVHEAKVAKELGLDV.IITDHH.EPGP---....-ELPDVRAIVHPKQ---.-PG 45 ...A......AVHEAKVAKELGLDV.IITDHH.EPGP---....-ELPDVRAIVHPKQ---.-PG 46 ...A......AVHEAKVAKELGLDV.IITDHH.EPGP---....-ELPDVRAIVHPKQ---.-PG 47 ...T......NLDEIVYAQQLGMDV.IVTDHH.TLPD---....-DRPEVVAIINPRY---.-FA 48 ...T......NLDEIVYAQQLGMDV.IVTDHH.TLPD---....-DRPEVVAIINPRY---.-FA 49 ...T......NLDEIVYAQQLGMDV.IVTDHH.TLPD---....-DRPEVVAIINPRY---.-FA 50 ...A......ALEAAKLCKEKNIDL.IITDHH.MPQD---....-ILPDAFAIINPKQ---.-KD 51 ...N......AFEAAQFCKEKNYTL.IITDHH.CLHH---....DEIPDAYAVINPKQ---.-PD 52 ...N......AFEAARFCKEKNYTL.IITDHH.CLHH---....DEVPDAYAVINPKQ---.-PD 53 ...N......AFEAARFCKEKNYTL.IITDHH.CLHH---....DEVPDAYAVINPKQ---.-PD 54 ...N......AFEAARFCKEKNYTL.IITDHH.CLHH---....DEVPDAYAVINPKQ---.-PD 55 ...S......NLDEVKSLLATGTEV.VVTDHH.APGE---....--NFPECLVVHPHL---.TPD 56 ...M......AHDALKYAKDVKLDV.IVIDHH.ISTE---....-ILPDAVAIVNPNR---.-ID 57 ...M......AHDALKYAKDVKLDV.IVIDHH.ISTE---....-ILPDAVAIVNPNR---.-ID 58 ...M......AHDALKYAKDVKLDV.IVIDHH.ISTE---....-ILPDAVAIVNPNR---.-ID 59 ...-......--SAVEEIDQSSLET.VVIDHH.NVPP---....-RIPKKALIVNPKV---.-GA 60 ...-......--SAVEEIDQSSLET.VVIDHH.NVPP---....-RIPKKALIVNPKV---.-GA 61 ...-......--SAVEEIDQSSLET.VVIDHH.NVPP---....-RIPKKALIVNPKV---.-GA 62 ...L......AADMIDKINAGKSMV.LIIDHH.PAKD---....-IDSDYVHVLDPELAGI.SGD 63 ...L......AADMIDKINAGKSMV.LIIDHH.PAKD---....-IDSDYVHVLDPELAGI.SGD 64 ...L......AADMIDKINAGKSMV.LIIDHH.PAKD---....-IDSDYVHVLDPELAGI.SGD 65 kmiK......EKLDELNLSDKRDKI.IILDHH.QPEE---....IKIPKTIIHINPLTIAK.SGA 66 kmiK......EKLDELNLSDKRDKI.IILDHH.QPEE---....IKIPKTIIHINPLTIAK.SGA 67 kmiK......EKLDELNLSDKRDKI.IILDHH.QPEE---....IKIPKTIIHINPLTIAK.SGA 68 ...L......SLIGEHL---KDKSV.VILDHH.PPEP---....VETHEKHILANPVQFGA.NSV 69 ...L......SLIGEHL---KDKSV.VILDHH.PPEP---....VETHEKHILANPVQFGA.NSV 70 ...L......SLIGEHL---KDKSV.VILDHH.PPEP---....VETHEKHILANPVQFGA.NSV 71 ...L......SIIKEHL---KDRTV.IILDHH.PPEN---....VELPEKHILVNPVQFGA.NSV 72 ...-......--AYLEEISRLKGDV.IVADHH.QPSE---....SEAGPHVVHINPHLHGL.DGS 73 ...-......--AYLEEISRLKGDV.IVADHH.QPSE---....SEAGPHVVHINPHLHGL.DGS 74 ...-......--AYLEEISRLKGDV.IVADHH.QPSE---....SEAGPHVVHINPHLHGL.DGS 75 ...-......--GYADLISQVDTDV.VILDHH.IPNG--E....IRPKRNLAHVNPHLVGM.DGT 76 ...-......--GYADLISQVDTDV.VILDHH.IPNG--E....IRPKRNLAHVNPHLVGM.DGT 77 ...-......--GYADLISQVDTDV.VILDHH.IPNG--E....IRPKRNLAHVNPHLVGM.DGT 78 ...-......--GQIEEIIKHNFNA.IILDHH.PPVI-KD....SFINENIIQLNPHIFGV.DGS 79 ...-......--GQIEEIIKHNFNA.IILDHH.PPVIKDS....F-INENIIQLNPHIFGV.DGS 80 ...-......--GQIEEIIKHNFNA.IILDHH.PPVIKDS....F-INENIIQLNPHIFGV.DGS 81 ...-......-GQRVHENLKSNSRV.LILDHH.PPVRKMNf...TAPSGDFLEINPIFYGM.DGS 82 ...-......-GQRVHENLKSNSRV.LILDHH.PPVRKMNf...TAPSGDFLEINPIFYGM.DGS 83 ...-......-GQRVHENLKSNSRV.LILDHH.PPVRKMNf...TAPSGDFLEINPIFYGM.DGS 84 ...-......----GVLNMLDGIEF.AITDHH.LPQS---....----HHPMQLNPHDFGY.DGA 85 ...-......----GVLNMLDGIEF.AITDHH.LPQS---....----HHPMQLNPHDFGY.DGA 86 ...-......----GVLNMLDGIEF.AITDHH.LPQS---....----HHPMQLNPHDFGY.DGA 87 ...-......--FYRVGKEVKVGKR.IRIDHH.VGGE---....--FYGMHDYIDPTA---.-PA 88 ...-......--FYRVGKEVKVGKR.IRIDHH.VGGE---....--FYGMHDYIDPTA---.-PA 89 ...R......VGKEV-----KVGKR.IRIDHH.VGGE---....--FYGMHDYIDPTA---.-PA 90 ...P......SLVMEERLVNKIEHI.VVIDHH.RRGE--E....FIRDPLLVYMEPYA---.-SS 91 ...P......SLVMEERLVNKIEHI.VVIDHH.RRGE--E....FIRDPLLVYMEPYA---.-SS 92 ...P......SLVMEERLVNKIEHI.VVIDHH.RRGE--E....FIRDPLLVYMEPYA---.-SS 93 ...-......-IEQLEPIEVPPAKI.VVIDHH.VEKE---....NPIPADVAIIDPTR---.-TS 94 ...-......-IEQLEPIEVPPAKI.VVIDHH.VEKE---....NPIPADVAIIDPTR---.-TS 95 ...-......-IEQLEPIEVPPAKI.VVIDHH.VEKE---....NPIPADVAIIDPTR---.-TS 96 ...E......QL--EPIKIPPNAKL.IVIDHH.VEKE---....NPIPADISVIDPKR---.-TS 97 ...-......--LPEGLPRERIKRI.IVYDHH.PIGD---....--VKEFEGKIEKV----.-GA 98 ...-......--LPEGLPRERIKRI.IVYDHH.PIGD---....--VKEFEGKIEKV----.-GA 99 ...E......GLPRERI-----KRI.IVYDHH.PIGD---....--VKEFEGKIEKV----.-GA 100 ...D......RIPESIRKKAQGAKI.TVYDHH.VDES---....----PYDGIVSKV----.-GA 101 ...D......RIGDEFIFYVKNMPT.LVIDHH.MSGE---....--KLECEGYIDPFA---.-PS 102 ...D......RIGDEFIFYVKNMPT.LVIDHH.MSGE---....--KLECEGYIDPFA---.-PS 103 ...D......RIGDEFIFYVKNMPT.LVIDHH.MSGE---....--KLECEGYIDPFA---.-PS 104 ...S......RVGAELASQLAPFAR.AFIDHH.ETCG---....--DHCAHSFVVKTA---.-PS 105 ...S......RVGAELASQLAPFAR.AFIDHH.ETCG---....--DHCAHSFVVKTA---.-PS 106 ...S......RVGAELASQLAPFAR.AFIDHH.ETCG---....--DHCAHSFVVKTA---.-PS 107 ...D......RLGALGDLTDSGREL.LVIDHH.ASND---....--LFGTANFIDPSA---.-DS 108 ...D......RLGALGDLTDSGREL.LVIDHH.ASND---....--LFGTANFIDPSA---.-DS 109 ...D......RLGALGDLTDSGREL.LVIDHH.ASND---....--LFGTANFIDPSA---.-DS 110 ...P......VRVAGADLTQFDGPV.VNVDHH.GTNL---....--RRADAGVVDPSK---.-PA 111 ...R......IGKFQDLLDK--VPS.VVIDHH.STNT---....--NFGNWNWVDPSF---.-AA 112 ...Q......IAGAESLFRAARL-K.VVIDHH.ERGS---....IHEEADVALVDPGA---.-GS 113 ...Q......SFDDLEEGKL----I.AIIDHH.KVGL---....TTTEPILYYAKPV----.-GS 114 ...Q......TVDGIDKAEV----V.AIVDHH.KIGD---....VTTPQPILFVNLPV---.-GC 115 ...Q......SLPALGELDV----T.RVVDHH.KLGD--L....TTINPPYLRFEPV----.-GC 116 ...Q......SVADIAEVEV----Y.GVVDHH.RVAN--F....ETANPLYMRLEPV----.-GS 117 ...Q......SIADIREVEV----V.EVVDHH.RVAN--F....ETANPLYMRLEPV----.-GS 118 ...Q......SIKDIEEVQV----L.EVIDHH.RIAN--F....ETAEPLYYRAEPV----.-GC 119 ...Q......APDDLNQAEI----L.GIVDHH.RLGD--V....MTVNPLEAWIWPV----.-GC 120 ...N......GNITILDEEDLNKIE.IIIDHHqILQNLRE....KLPPNCFVDIRTDV---.-NA 121 ...N......GNITILDEEDLNKIE.IIIDHHqILQNLRE....KLPPNCFVDIRTDV---.-NA 122 ...N......GNITILDEEDLNKIE.IIIDHHqILQNLRE....KLPPNCFVDIRTDV---.-NA 123 ...N......GNITILDDDDLKRVE.IIVDHHqILQNLRE....KLSPNCFVDIRTDV---.-NA 124 ...-......--SKQLPIELPNID-.IIIDHH.NNTD---....--LTAKYMDVRPEV---.-GA 125 ...-......--SKQLPIELPNID-.IIIDHH.NNTD---....--LTAKYMDVRPEV---.-GA 126 ...K......QLPIELPNID-----.IIIDHH.NNTD---....--LTAKYMDVRPEV---.-GA 127 ...-......--PGVNNSIPPDIDIsIVIDHH.PAEK---....--VVAEFVDLREDV---.-GA 128 ...-......--PGVNNSIPPDIDIsIVIDHH.PAEK---....--VVAEFVDLREDV---.-GA 129 ...-......--PGVNNSIPPDIDIsIVIDHH.PAEK---....--VVAEFVDLREDV---.-GA 130 ...S......QLMPLVQEANIPV-V.VIIDHH.SPQD--E....VEAEGAFVDIRPSS---.-RS 131 ...S......QLMPLVQEANIPV-V.VIIDHH.SPQD--E....VEAEGAFVDIRPSS---.-RS 132 ...S......QLMPLVQEANIPV-V.VIIDHH.SPQD--E....VEAEGAFVDIRPSS---.-RS 133 ...N......QERVLSQKHRLAKKT.ILVDHH.VKTI---....--TYTDLEYINDQS---.-IA 134 ...N......QERVLTQKHKLAKET.VRIDHH.PRTE---....--KFADMEWIDSSF---.-SA 135 ...N......QERVLTQKHKLAKET.VRIDHH.PKTE---....--SFADLEWIDPAF---.-SA 136 ...N......QERVLTQKHKLAKET.VRIDHH.PKTE---....--SFADLEWIDPAF---.-SA 137 ...N......QERVLTQKHKLAKET.VRIDHH.PKTE---....--SFADLEWIDPAF---.-SA 138 ...N......QERIDDQRYPSGAKL.MKIDHH.PNED---....--PYGDLLWVDTSA---.-SS 139 ...N......QERIDDQRYPSGAKL.MKIDHH.PNED---....--PYGDLLWVDTSA---.-SS 140 ...N......QERIDDQRYPSGAKL.MKIDHH.PNED---....--PYGDLLWVDTSA---.-SS 141 ...I......NQLKVNFDELKEREV.ILIDHH.KKTD---....LADICKYYIIKEDY---.-PS 142 ...I......NQLKVNFDELKEREV.ILIDHH.KKTD---....LADICKYYIIKEDY---.-PS 143 ...I......NQLKVNFDELKEREV.ILIDHH.KKTD---....LADICKYYIIKEDY---.-PS 144 ...R......IECRDLLDQNQFKAV.LRIDHH.PNED---....-DLNTTHNFVDASY---.-IA 145 ...R......IECRDLLDQNQFKAV.LRIDHH.PNED---....-DLNTTHNFVDASY---.-IA 146 ...R......IECRDLLDQNQFKAV.LRIDHH.PNED---....-DLNTTHNFVDASY---.-IA 147 ...R......IECRDLLDQNQFKAV.LRIDHH.PNED---....-DLNTTHNFVDASY---.-IA 148 ...R......IELRELLDKNLFKAV.LRIDHH.PNED---....-DLNTSFNFVEESY---.-VA 149 ...R......IELRELLDKNLFKAV.LRIDHH.PNED---....-DLNTSFNFVEESY---.-VA 150 ...R......IELRELLDKNLFKAV.LRIDHH.PNED---....-DLNTSFNFVEESY---.-VA 151 ...R......IELRELLDKNLFKAV.LRIDHH.PNED---....-DLNTSFNFVEESY---.-VA 152 ...-......----PREAEKLRVPT.VFIDHH.SQPR---....-IKNPLVKHVNPVLEGRyYPS 153 ...D......VEGIEKE-------T.VFIDHH.IQPK---....-IKNPRVRQINPSLEGKeSPS 154 ...D......VEGIE-------KET.VFIDHH.IQPK---....-IKNPRVRQINPSLEGKeSPS 155 ...D......VEGIE-------KET.VFIDHH.IQPK---....-IKNPRVRQINPSLEGKeSPS 156 ...E......NEERLNEYVHAGGKV.KLIDHH.KTALHLN....E-HEWGFVQVEYDDGRL.TSA 157 ...E......NEERLNEYVHAGGKV.KLIDHH.KTALHLN....E-HEWGFVQVEYDDGRL.TSA 158 ...E......NEERLNEYVHAGGKV.KLIDHH.KTALHLN....E-HEWGFVQVEYDDGRL.TSA 159 ...NeaeylqDKIQEHRLQNKDIQI.QLLDHH.ISGKEVA....ESFHWYFLDTNRCA---.--- 160 ...NeaeylqDKIQEHRLQNKNIQI.QLLDHH.ISGKEVA....ESFHWYFLDINRCA---.--- 161 ...NeaeylqDKIQEHRLQNKNIQI.QLLDHH.ISGKEVA....ESFHWYFLDINRCA---.--- 162 ...NeaeylqDKIQEHRLQNKNIQI.QLLDHH.ISGKEVA....ESFHWYFLDINRCA---.--- 163 ...E......DVPAIRQFLLFGADV.ITIDHH.FPDE---....EVDSYLLYHVNPYKVGG.DSN 164 ...E......DVPAIRQFLLFGADV.ITIDHH.FPDE---....EVDSYLLYHVNPYKVGG.DSN 165 ...E......DVPAIRQFLLFGADV.ITIDHH.FPDE---....EVDSYLLYHVNPYKVGG.DSN 166 ...E......DILALMKAKIYDIEI.VVVDHH.YPGEVQDgrv.EVDEYVDTHVNPYLVGG.DSQ 167 ...E......DILALMKAKIYDIEI.VVVDHH.YPGEVQDgrv.EVDEYVDTHVNPYLVGG.DSQ 168 ...E......DILALMKAKIYDIEI.VVVDHH.YPGEVQDgrv.EVDEYVDTHVNPYLVGG.DSQ 169 ...E......DIPAISKAKAYGIEV.IVIDHH.FPGEVVDgkv.EVDDYVDAHVNPYLVGG.DSN 170 ...E......DIPAISKAKAYGIEV.IVIDHH.FPGEVVDgkv.EVDDYVDAHVNPYLVGG.DSN 171 ...E......DIPAISKAKAYGIEV.IVIDHH.FPGEVVDgkv.EVDDYVDAHVNPYLVGG.DSN 172 ...E......DIPAYKRLKAYGVKI.VVIDHH.DPREWISedkaKVDEYVDVHVNPHH---.--- 173 ...E......DIPAYKRLKAYGVKI.VVIDHH.DPRDWISedkaKVDEYVDVHVNPHH---.--- 174 ...E......DIPAYKRLKAYGVKI.VVIDHH.DPRDWISedkaKVDEYVDVHVNPHH---.--- 175 ...E......DIPAYKRLKAYGVKI.VVIDHH.DPRDWISedkaKVDEYVDVHVNPHH---.--- 176 ...A......PPSCRLLLSDSTIRK.IELDHH.LFANAAC....CGDPGYSLIARA-----.-SS 177 ...A......PPSCRLLLSDSTIRK.IELDHH.LFANAAC....CGDPGYSLIARA-----.-SS 178 ...A......PPSCRLLLSDSTIRK.IELDHH.LFANAAC....CGDPGYSLIARA-----.-SS 0 150 160 170 180 | | | | | 1 DANYYSGAFTSALVFSQIFQTQTT..PL.......E........EELIAITLLS-------drid 2 DANYYSGAFTSALVFSQIFQTQTT..PL.......E........EELIAITLLS-------drid 3 DAN---YYSGAFTSALVFSQIFQT..QT.......T........PLEEELIAITLLSD---.... 4 DAN---YYSGAFTSALVFSQIFQT..QT.......T........PLEEELIAITLLSD---.... 5 DAN---YYSGAFTSALVFSQIFQI..QT.......T........PLEEELIAITLLSD---.... 6 PNYSNKTLTGAGMAYKFCQAIDEK..LN.......Knea.....EQFLDLVSIGNIAD---sad. 7 PNYSNKTLTGAGMAYKFCQAIDEK..LN.......Knea.....EQFLDLVSIGNIAD---sad. 8 PNYSNKTLTGAGMAYKFCQAIDEK..LN.......Knea.....EQFLDLVSIGNIADS--.... 9 AGYPHEFLSGCATAWKVVTA----..--.......-........-----------------.... 10 AGYPHEFLSGCATAWKVVTA----..--.......-........-----------------lr16 11 AGYPHEFLSGCATAWKVVTA----..--.......-........-----------------lr16 12 NPYPNKELTGVGVAFKLVCATYEE..LI.......Qqda11idlLRFLDLVSLGTIADVGR.... 13 NPYPNKELTGVGVAFKLVCATYEE..LI.......Qqda11idlLRFLDLVSLGTIADVGR.... 14 NPYPNKELTGVGVAFKLVCATYEE..LI.......Qqda11idlLRFLDLVSLGTIADVGR.... 15 NSYPNKELTGVGVAFKLVCATYEE..LI.......Kqda11idlLHFLDLVSLGTIADVGR.... 16 RAYPNKELTGVGVAFKLARGVLNA..LR.......Kenp9kvdtKHLLDLVTLGTVTDVG-.... 17 RAYPNKELTGVGVAFKLARGVLNA..LR.......Kenp9kvdtKHLLDLVTLGTVTDVG-t... 18 RAYPNKELTGVGVAFKLARGVLNA..LR.......Kenp9kvdtKHLLDLVTLGTVTDVG-t... 19 HTYPNRELTGVGVAFKLARGVLNA..LI.......Srnl11gslKKLLDLVTLGTITDVG-v... 20 HTYPNRELTGVGVAFKLARGVLNA..LI.......Srnl11gslKKLLDLVTLGTITDVG-v... 21 HTYPNRELTGVGVAFKLARGVLNA..LI.......Srnl11gslKKLLDLVTLGTITDV--.... 22 DKYPFKEIAGCCVSFKACLA----..--.......-........-----------------ls16 23 DKYPFKEIAGCCVSFKACLA----..--.......-........-----------------ls16 24 DKYPFKEIAGCCVSFKACLAL---..--.......-........-----------------.... 25 DKYPFKEIAGCCVSFKACLAL---..--.......-........-----------------.... 26 DKYPFKEIAGCCVSFKACLAL---..--.......-........-----------------.... 27 CNFPSKSLAGVGVAFYLMLALRTF..LR.......Dqgw14pnlAELLDLVALGTVADVV-p... 28 CNFPSKSLAGVGVAFYLMLALRTF..LR.......Dqgw14pnlAELLDLVALGTVADVV-p... 29 CNFPSKSLAGVGVAFYLMLALRTF..LR.......Dqgw14pnlAELLDLVALGTVADVVP.... 30 CNFPSKSLAGVGVAFYLMLALRTF..LR.......Dqgw14pnlAELLDLVALGTVADVVP.... 31 CAFPSKALAGVGVAFYLMMALRAN..LR.......Ecgw14pnlAELLDLVALGTVADVVP.... 32 CAFPSKALAGVGVAFYLMMALRAN..LR.......Ecgw14pnlAELLDLVALGTVADVV-p... 33 CAFPSKALAGVGVAFYLMMALRAN..LR.......Ecgw14pnlAELLDLVALGTVADVV-p... 34 CAFPSKALAGVGVAFYLMMALCVH..MR.......Qqgw14pklMELIDLVALGTVADVVP.... 35 CGFPSKSLAGVGVAFYLMLAVRAK..FR.......Elgi12pnfTDLLDLVALGTIADVVP.... 36 CGFPSKSLAGVGVAFYLMLAVRAK..FR.......Elgi12pnfTDLLDLVALGTIADVV-p... 37 CGFPSKSLAGVGVAFYLMLAVRAK..FR.......Elgi12pnfTDLLDLVALGTIADVV-p... 38 CGFPSKSLAGVGVIFYVLMALRAE..LR.......Rrny13pnlGELLDLVALGTVADVVP.... 39 CGFPSKSLAGVGVIFYVLMALRAE..LR.......Rrny13pnlGDLLDLVALGTVADV--.... 40 CGFPSKSLAGVGVIFYVLTALRAE..LR.......Rrny13pnlGGLLDLVALGTVADVVP.... 41 DSFPSKTLAGVGVIFYVLLALRGV..LR.......Arga12pdlSVLLDLVAVGTVADLV-.... 42 DLFPSKTLAGVGVIFYVLLALRAR..LY.......Pvah25pdlTSLLDLVAVGTVADLV-.... 43 ENYPFRDLAGVGVTYKLVQALSEA..TN.......Yphp.....ERFLELVALGTVADMV-.... 44 CTYPFKELAGVGVAFKLAHALLGE..LP.......D........-ELLDLAAIGTIADLV-p... 45 CTYPFKELAGVGVAFKLAHALLGE..LP.......D........-ELLDLAAIGTIADLV-p... 46 CTYPFKELAGVGVAFKLAHALLGE..LP.......D........-ELLDLAAIGTIADLV-.... 47 DGHPLFNLSGVAVAFKLVEALYNQ..YP.......Tvpqqpl..EDLLDLVAIGLIADL--.... 48 DGHPLFNLSGVAVAFKLVEALYNQ..YP.......Tvpqqpl..EDLLDLVAIGLIADL--vt.. 49 DGHPLFNLSGVAVAFKLVEALYNQ..YP.......Tvpqqpl..EDLLDLVAIGLIADL--vt.. 50 CDFPEIEICGAQVAWYLIAALKEVc.-K.......Lkydm....CKFLELLAIAIVADMM-.... 51 CDFIQKEVCGALVAFYLCYGIHQL..LG.......Kekshs...SELLCLAGVATIADMMP.... 52 CDFIQKEVCGALVAFYLCYGIHQL..LG.......Kekshs...SELLCLAGVATIADMMP.... 53 CDFIQKEVCGALVAFYLCYGIHQL..LG.......Kekshs...SELLCLAGVATIADMMP.... 54 CDFIQKEVCGALVAFYLCYGIHQL..LG.......Kekshs...SELLCLAGVATIADMMP.... 55 YDPDRHNLTGAGVAYHLLWAVYEE..LG.......Rpep.....RALLPLATLGTVADV--.... 56 ETSEYKYLAAVGVTFLFATAILSN..LK.......Krny13pnlMKYLDLVALGTVCDMM-.... 57 ETSEYKYLAAVGVTFLFATAILSN..LK.......Krny13pnlMKYLDLVALGTVCDMM-k... 58 ETSEYKYLAAVGVTFLFATAILSN..LK.......Krny13pnlMKYLDLVALGTVCDMM-k... 59 KREGLKALSSSALSFYLGSALIRE..FNlded...P........RNFLDLVALGLLADYMP.... 60 KREGLKALSSSALSFYLGSALIRE..FNlded...P........RNFLDLVALGLLADYMP.... 61 KREGLKALSSSALSFYLGSALIRE..FNlded...P........RNFLDLVALGLLADYMP.... 62 -----VFVSASSLNYIFFRAVAGE..E-.......A........KKYAYIAVLGSVGDY--.... 63 -----VFVSASSLNYIFFRAVAGE..E-.......A........KKYAYIAVLGSVGDY--hd.. 64 -----VFVSASSLNYIFFRAVAGE..E-.......A........KKYAYIAVLGSVGDY--hd.. 65 ------EICGAGVSYLFAKAINND..WI.......D........--LAKYAVLGAVGDIQN.... 66 ------EICGAGVSYLFAKAINND..WI.......D........--LAKYAVLGAVGDIQN.... 67 ------EICGAGVSYLFAKAINND..WI.......D........--LAKYAVLGAVGDIQN.... 68 -----RDLSGSGVSYFFAREL--N..EM.......N........KDLAYIAIVGAVGDMQ-.... 69 -----RDLSGSGVSYFFAREL--N..EM.......N........KDLAYIAIVGAVGDMQ-e... 70 -----RDLSGSGVSYFFAREL--N..EM.......N........KDLAYIAIVGAVGDMQ-e... 71 -----RDLSGSGVCYFFAREL--N..ER.......N........KDLAYIAIVGAVGDMQ-.... 72 -----RDLSASGTAYL-----ATR..LL.......N........RKTAPLALVGALGDMQ-y... 73 -----RDLSASGTAYL-----ATR..LL.......N........RKTAPLALVGALGDMQ-y... 74 -----RDLSASGTAYL-----ATR..LL.......N........RKTAPLALVGALGDMQ-.... 75 -----FELSASGVCYFFA---NEL..GR.......N........RELASVALIGALGDKQR.... 76 -----FELSASGVCYFFA---NEL..GR.......N........RELASVALIGALGDKQR.... 77 -----FELSASGVCYFFA---NEL..GR.......N........RELASVALIGALGDKQR.... 78 -----REITASGVCYLV----ARE..FG.......Y........YDLSVLAIVGIIGDMQ-.... 79 -----REITASGVCYLV----ARE..FG.......Y........YDLSVLAIVGIIGDMQ-y... 80 -----REITASGVCYLV----ARE..FG.......Y........YDLSVLAIVGIIGDMQ-y... 81 -----THVSGGGLTYLL----ARE..FG.......Y........RDLSWMGLLAAVGDMQN.... 82 -----THVSGGGLTYLL----ARE..FG.......Y........RDLSWMGLLAAVGDMQN.... 83 -----THVSGGGLTYLL----ARE..FG.......Y........RDLSWMGLLAAVGDMQN.... 84 -----FELSGATTTYLVSKYLRNG..RTlfdyendN........SDLLPISIVGAVGDLQ-d... 85 -----FELSGATTTYLVSKYLRNG..RTlfdyendN........SDLLPISIVGAVGDLQ-d... 86 -----FELSGATTTYLVSKYLRNG..RTlfdy...-endn....SDLLPISIVGAVGDLQ-.... 87 TAALVYEIIKNW---------DET..AI.......D........KDIATCIYTGLATDTG-f... 88 TAALVYEIIKNW---------DET..AI.......D........KDIATCIYTGLATDTG-f... 89 TAALVYEIIKNW---------DET..AI.......D........KDIATCIYTGLATDTG-.... 90 TAELVTELLEY--------QPKRL..KI.......N........MIEATALLAGIIVDT--.... 91 TAELVTELLEY--------QPKRL..KI.......N........MIEATALLAGIIVDT--ks.. 92 TAELVTELLEY--------QPKRL..KI.......N........MIEATALLAGIIVDT--ks.. 93 TAEIVWELFKK-----------FN..YS.......D........ENSAKALLAGIISDTS-n... 94 TAEIVWELFKK-----------FN..YS.......D........ENSAKALLAGIISDTS-n... 95 TAEIVWELFKK-----------FN..YS.......D........ENSAKALLAGIISDTS-.... 96 TAEIVWELFKK----------LGY..K-.......D........EDSAKVLLAAIISDT--.... 97 ATTLVVEEIKE----------KGI..DI.......N........PRDATLLAFGIYEDTGN.... 98 ATTLVVEEIKE----------KGI..DI.......N........PRDATLLAFGIYEDTGN.... 99 ATTLVVEEIKE----------KGI..DI.......N........PRDATLLAFGIYEDTGN.... 100 TITILVELIRE----------KNI..PL.......D........PTEATLFMIALYDDTGN.... 101 TTFLIEKLIRE----------FGH..DL.......T........KEEAWYILVGFCTDTG-.... 102 TTFLIEKLIRE----------FGH..DL.......T........KEEAWYILVGFCTDTG-f... 103 TTFLIEKLIRE----------FGH..DL.......T........KEEAWYILVGFCTDTG-f... 104 TTTLVQTLIET----------MAG..SL.......E........AAEARALFLGLATDTG-.... 105 TTTLVQTLIET----------MAG..SL.......E........AAEARALFLGLATDTG-f... 106 TTTLVQTLIET----------MAG..SL.......E........AAEARALFLGLATDTG-f... 107 TTTMVAEILDA----------WGK..PI.......D........PRVAHCIYAGLATDTG-s... 108 TTTMVAEILDA----------WGK..PI.......D........PRVAHCIYAGLATDTG-s... 109 TTTMVAEILDA----------WGK..PI.......D........PRVAHCIYAGLATDTG-.... 110 AAMMVADVIDA----------LGA..PW.......S........EAVATPLMLGLNTDTGN.... 111 TAQMIFRINKA----------LGV..EY.......D........SNLATLNYLGIATDTG-.... 112 SSELAVKTAVE----------AGT..PL.......R........PSVATAALGGIVYDTGR.... 113 TATVIAELYFKDAIDLI--GGKKK..EL.......K........PDLAGLLLSAIISDT--.... 114 TATVIKLLFDK----------TGV..EI.......P........KDIAGILLSSILSDT--.... 115 TGTILLKLHRE----------AGL..SV.......E........PQDAKLMLSAILSDT--.... 116 ASSIVYRMFKE----------HSV..AV.......S........KEIAGLMLSGLISDT--.... 117 ASSIVYRLYKE----------NGV..AI.......P........KEIAGVMLSGLISDT--.... 118 TATILNKMYKE----------NNV..KI.......E........KEIAGLMLSAIISD---.... 119 TSTILFNLFKM----------ENA..EI.......T........RPLALLMISAILSDTV-.... 120 TSSIMAEYLKA----------LEI..PI.......T........ETLATALFYGMYIDT--kk.. 121 TSSIMAEYLKA----------LEI..PI.......T........ETLATALFYGMYIDT--kk.. 122 TSSIMAEYLKA----------LEI..PI.......T........ETLATALFYGMYIDT--.... 123 TSSIMVEYLKA----------LEI..PI.......T........DTLATALFYGMYIDT--.... 124 TASILTQYLME----------LDI..EP.......S........RNLATALFYGIQSDT--dy.. 125 TASILTQYLME----------LDI..EP.......S........RNLATALFYGIQSDT--dy.. 126 TASILTQYLME----------LDI..EP.......S........RNLATALFYGIQSDT--.... 127 TATILTEYIKE----------LKI..TP.......S........KILATALFFGIKSE---.... 128 TATILTEYIKE----------LKI..TP.......S........KILATALFFGIKS----etde 129 TATILTEYIKE----------LKI..TP.......S........KILATALFFGIKS----etde 130 TATILTEYLQGGMLDFN----SSN..PT.......H........VKCATALMHGLRSDTI-n... 131 TATILTEYLQGGMLDFN----SSN..PT.......H........VKCATALMHGLRSDTI-n... 132 TATILTEYLQGGMLDFN----SSN..PT.......H........VKCATALMHGLRSDTI-.... 133 ACEMIAYSLMH----------TNL..NF.......D........LKTLNYLLLGITTDSN-.... 134 TAEMIGYLILQ----------MGY..KL.......N........DEIASYLYAGIITDTQR.... 135 AAEMVGYLILQ----------MGY..EL.......N........AEMAAYIYAGIITDTQR.... 136 AAEMVGYLILQ----------MGY..EL.......N........AEMAAYIYAGIITDTQR.... 137 AAEMVGYLILQ----------MGY..EL.......N........AEMAAYIYAGIITDTQR.... 138 VSEMIYELYLEGKE-------HGW..KL.......N........TKAAELIYAGIVGDTGR.... 139 VSEMIYELYLEGKE-------HGW..KL.......N........TKAAELIYAGIVGDTGR.... 140 VSEMIYELYLEGKE-------HGW..KL.......N........TKAAELIYAGIVGDTGR.... 141 TSEIIAEIFKE----------LNI..FP.......P........KNVRIALLCGIVYDT--.... 142 TSEIIAEIFKE----------LNI..FP.......P........KNVRIALLCGIVYDT--kh.. 143 TSEIIAEIFKE----------LNI..FP.......P........KNVRIALLCGIVYDT--kh.. 144 AAEQVVDLAVQ----------AKW..KL.......S........PPAATALYLGIYTDSN-r... 145 AAEQVVDLAVQ----------AKW..KL.......S........PPAATALYLGIYTDSN-r... 146 AAEQVVDLAVQ----------AKW..KL.......S........PPAATALYLGIYTDSN-.... 147 AAEQVVDLAVQ----------AKW..KL.......S........PPAATALYLGIYTDSN-.... 148 CCEQIVEMATV----------AKW..TI.......P........PVAATLLYIGIYTDSN-.... 149 CCEQIVEMATV----------AKW..TI.......P........PVAATLLYIGIYTDSN-.... 150 CCEQIVEMATV----------AKW..TI.......P........PVAATLLYIGIYTDSN-r... 151 CCEQIVEMATV----------AKW..TI.......P........PVAATLLYIGIYTDSN-r... 152 ASFVVSEYLNY-------------..--.......-........--WNEWSALGVVGDI--.... 153 ASFVVSEYFDV-------------..--.......-........--WNTWTALGAVGDVG-.... 154 ASFVVSEYFDV-------------..--.......-........--WNTWTALGAVGDVG-e... 155 ASFVVSEYFDV-------------..--.......-........--WNTWTALGAVGDVG-e... 156 TSLLYGYLIEN-------------..--.......-........-----------------.... 157 TSLLYGYLIENG------------..--.......-........-----------------fmk1 158 TSLLYGYLIENG------------..--.......-........-----------------fmk1 159 -TKIVYEFLKKYYAIL--------..--.......-........-----------------.... 160 -TKIVYEFLKKHYAI------LEP..KN.......T........TWL--------------.... 161 -TKIVYEFLKKHYA----------..--.......-........-----------------ile1 162 -TKIVYEFLKKHYA----------..--.......-........-----------------ile1 163 YTSGVLCVEIA-----------RM..IS.......D........LDMKHLAAISVVGD---.... 164 YTSGVLCVEIA-----------RM..IS.......D........LDMKHLAAISVVGD---rae. 165 YTSGVLCVEIA-----------RM..IS.......D........LDMKHLAAISVVGD---rae. 166 ITAGSLSVEIA--------KMINP..EI.......A........ERILHLPGIAAVGD---.... 167 ITAGSLSVEIA--------KMINP..EI.......A........ERILHLPGIAAVGD---han. 168 ITAGSLSVEIA--------KMINP..EI.......A........ERILHLPGIAAVGD---han. 169 LTAGVLGTEIA--------RMINP..DV.......E........DEIKHIPGIAVVGD---hak. 170 LTAGVLGTEIA--------RMINP..DV.......E........DEIKHIPGIAVVGD---hak. 171 LTAGVLGTEIA--------RMINP..DV.......E........DEIKHIPGIAVVGD---.... 172 VKRGYYELTAGMLATEVARFI-NP..EV.......E........DKIKHLPAIAGTGD---.... 173 VKRGYYELTAGMLATEVARYV-NP..AV.......E........DKIKHLPAIAGTGD---.... 174 VKRGYYELTAGMLATEVARYVNPA..VE.......D........KIKHLPAIAG-------tgdr 175 VKRGYYELTAGMLATEVARYVNPA..VE.......D........KIKHLPAIAG-------tgdr 176 TCEIIAYLCYKLARNHAQRTALGIrnLY.......S........RNVVLSILTGMIGD---akt. 177 TCEIIAYLCYKLARNHAQRTALGIrnLY.......S........RNVVLSILTGMIGD---akt. 178 TCEIIAYLCYKLARNHAQRTALGIrnLY.......S........RNVVLSILTGMIGD---.... 1 ..... 2 ..... 3 ..... 4 ..... 5 ..... 6 ..... 7 ..... 8 ..... 9 ..... 10 7lmv. 11 7lmv. 12 ..... 13 ..... 14 ..... 15 ..... 16 ..... 17 ..... 18 ..... 19 ..... 20 ..... 21 ..... 22 5nmp. 23 5nmp. 24 ..... 25 ..... 26 ..... 27 ..... 28 ..... 29 ..... 30 ..... 31 ..... 32 ..... 33 ..... 34 ..... 35 ..... 36 ..... 37 ..... 38 ..... 39 ..... 40 ..... 41 ..... 42 ..... 43 ..... 44 ..... 45 ..... 46 ..... 47 ..... 48 ..... 49 ..... 50 ..... 51 ..... 52 ..... 53 ..... 54 ..... 55 ..... 56 ..... 57 ..... 58 ..... 59 ..... 60 ..... 61 ..... 62 ..... 63 ..... 64 ..... 65 ..... 66 ..... 67 ..... 68 ..... 69 ..... 70 ..... 71 ..... 72 ..... 73 ..... 74 ..... 75 ..... 76 ..... 77 ..... 78 ..... 79 ..... 80 ..... 81 ..... 82 ..... 83 ..... 84 ..... 85 ..... 86 ..... 87 ..... 88 ..... 89 ..... 90 ..... 91 ..... 92 ..... 93 ..... 94 ..... 95 ..... 96 ..... 97 ..... 98 ..... 99 ..... 100 ..... 101 ..... 102 ..... 103 ..... 104 ..... 105 ..... 106 ..... 107 ..... 108 ..... 109 ..... 110 ..... 111 ..... 112 ..... 113 ..... 114 ..... 115 ..... 116 ..... 117 ..... 118 ..... 119 ..... 120 ..... 121 ..... 122 ..... 123 ..... 124 ..... 125 ..... 126 ..... 127 ..... 128 ..... 129 ..... 130 ..... 131 ..... 132 ..... 133 ..... 134 ..... 135 ..... 136 ..... 137 ..... 138 ..... 139 ..... 140 ..... 141 ..... 142 ..... 143 ..... 144 ..... 145 ..... 146 ..... 147 ..... 148 ..... 149 ..... 150 ..... 151 ..... 152 ..... 153 ..... 154 ..... 155 ..... 156 ..... 157 7vrq. 158 7vrq. 159 ..... 160 ..... 161 9vns. 162 9vns. 163 ..... 164 ..... 165 ..... 166 ..... 167 ..... 168 ..... 169 ..... 170 ..... 171 ..... 172 ..... 173 ..... 174 sk... 175 sk... 176 ..... 177 ..... 178 .....