; SAM: prettyalign v3.2 (July 31, 2000) compiled 08/11/00_16:27:51 ; (c) 1992-2000 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequences correspond to the following labels: ; 1 Q58598/358-537 ; 2 O26857/343-522 ; 3 O58078/350-531 ; 4 O28932/329-499 ; 5 O30161/24-173 ; 6 Y831_METJA/19-168 ; 7 O27473/31-174 ; 8 O57804/23-171 ; 9 O29559/20-162 ; 10 O29523/14-162 ; 11 Y977_METJA/15-169 ; 12 O26266/1-146 ; 13 O29950/1-131 ; 14 O25115/42-203 ; 15 Q9ZD22/80-250 ; 16 O32044/76-232 ; 17 RECJ_ECOLI/67-239 ; 18 RECJ_ERWCH/66-238 ; 19 RECJ_HAEIN/63-233 ; 20 O51269/73-370 ; 21 Q9Z7Z0/82-250 ; 22 P94659/11-177 ; 23 O84453/81-249 ; 24 O67909/73-229 ; 25 P73518/80-246 ; 26 O83702/72-370 ; 27 O31903/58-212 ; 28 O25177/21-204 ; 29 O66728/1-143 ; 30 YYBT_BACSU/333-502 ; 31 Y371_MYCPN/15-167 ; 32 O34600/8-159 ; 33 MGPA_MYCGE/55-209 ; 34 MGPA_MYCPN/17-173 ; 35 O67552/12-160 ; 36 O51564/17-170 ; 37 O83450/37-192 ; 38 P71615/29-184 ; 39 P72962/61-231 ; 40 YG33_METJA/160-312 ; 41 O28250/152-306 ; 42 O58017/157-321 ; 43 O73979/14-165 ; 44 Y988_METJA/5-161 ; 45 O83781/33-211 ; 46 O25683/3-150 ; 47 O31824/1-143 ; 48 Q58598/358-537 ; 49 O26857/343-522 ; 50 O58078/350-531 ; 51 O28932/329-499 ; 52 O30161/24-173 ; 53 Y831_METJA/19-168 ; 54 O27473/31-174 ; 55 O57804/23-171 ; 56 O29559/20-162 ; 57 O29523/14-162 ; 58 Y977_METJA/15-169 ; 59 O26266/1-146 ; 60 O29950/1-131 ; 61 O25115/42-203 ; 62 Q9ZD22/80-250 ; 63 O32044/76-232 ; 64 RECJ_ECOLI/67-239 ; 65 RECJ_ERWCH/66-238 ; 66 RECJ_HAEIN/63-233 ; 67 O51269/73-370 ; 68 Q9Z7Z0/82-250 ; 69 P94659/11-177 ; 70 O84453/81-249 ; 71 O67909/73-229 ; 72 P73518/80-246 ; 73 O83702/72-370 ; 74 O31903/58-212 ; 75 O25177/21-204 ; 76 O66728/1-143 ; 77 YYBT_BACSU/333-502 ; 78 Y371_MYCPN/15-167 ; 79 O34600/8-159 ; 80 MGPA_MYCGE/55-209 ; 81 MGPA_MYCPN/17-173 ; 82 O67552/12-160 ; 83 O51564/17-170 ; 84 O83450/37-192 ; 85 P71615/29-184 ; 86 P72962/61-231 ; 87 YG33_METJA/160-312 ; 88 O28250/152-306 ; 89 O58017/157-321 ; 90 O73979/14-165 ; 91 Y988_METJA/5-161 ; 92 O83781/33-211 ; 93 O25683/3-150 ; 94 O31824/1-143 ; 95 gi|3063673|gb|AAC14136.1|_11:176 ; 96 gi|7475820|pir||H69980_76:231 ; 97 gi|7451688|pir||H71513_82:249 ; 98 gi|7226077|gb|AAF41253.1|_68:237 ; 99 gi|2507106|sp|P21893|RECJ_ECOLI_68:239 ; 100 gi|9656991|gb|AAF95560.1|_69:241 ; 101 gi|96357|pir||C39202_69:240 ; 102 gi|1172895|sp|P45112|RECJ_HAEIN_65:233 ; 103 gi|2507107|sp|P39693|RECJ_ERWCH_66:238 ; 104 gi|7451687|pir||D72062_83:248 ; 105 gi|7451686|pir||G71656_80:249 ; 106 gi|2128720|pir||E64449_358:534 ; 107 gi|7379749|emb|CAB84317.1|_68:235 ; 108 gi|2498554|sp|P75144|MGPA_MYCPN_17:172 ; 109 gi|7462837|pir||F72243_73:231 ; 110 gi|7430137|pir||B70177_17:169 ; 111 gi|7450088|pir||A69202_343:519 ; 112 gi|7190761|gb|AAF39542.1|_83:249 ; 113 gi|7450090|pir||H69416_329:496 ; 114 gi|7228156|emb|CAB77039.1|_67:236 ; 115 gi|1346531|sp|P22746|MGPA_MYCGE_55:208 ; 116 gi|2842584|sp|Q58387|RECJ_METJA_17:169 ; 117 gi|7453624|gb|AAF62912.1|_68:237 ; 118 gi|9106065|gb|AAF83920.1|AE003946_11_44:225 ; 119 gi|4101624|gb|AAD01239.1|_73:206 ; 120 gi|7451685|pir||A70485_73:229 ; 121 gi|7463775|pir||F70131_73:206 ; 122 gi|6967533|emb|CAB72521.1|_47:204 ; 123 gi|7430136|pir||F69999_11:159 ; 124 gi|7477397|pir||H70693_35:183 ; 125 gi|4102237|gb|AAD09318.1|_73:206 ; 126 gi|7469901|pir||S74940_63:230 ; 127 gi|2496409|sp|Q49428|Y371_MYCGE_16:167 ; 128 gi|2496410|sp|P75229|Y371_MYCPN_17:167 ; 129 gi|7450091|pir||A75011_350:528 ; 130 gi|7450089|pir||A71141_350:528 ; 131 gi|7448980|pir||H71452_158:319 ; 132 gi|7519590|pir||E71279_33:208 ; 133 gi|9630257|ref|NP_046684.1|_58:210 ; 134 gi|7473679|pir||E75434_3:160 ; 135 gi|7450703|pir||G75192_25:171 ; 136 gi|7450704|pir||H71224_24:170 ; 137 gi|586814|sp|P37484|YYBT_BACSU_334:500 ; 138 gi|7445472|pir||F70440_14:159 ; 139 gi|7448979|pir||B75216_158:319 ; 140 gi|7514584|pir||D71323_38:191 ; 141 gi|7450701|pir||E69056_31:173 ; 142 gi|7450700|pir||B69086_2:146 ; 143 gi|7464994|pir||E71824_21:201 ; 144 gi|7470865|pir||S77224_80:244 ; 145 gi|7450702|pir||C69337_21:162 ; 146 gi|7482966|pir||C69259_26:171 ; 147 gi|7674163|sp|O68579|PPAC_STRMU_3:151 ; 148 gi|3024962|sp|Q58395|Y988_METJA_6:159 ; 149 gi|7464533|pir||B64696_22:201 ; 150 gi|7464253|pir||A64573_22:201 ; 151 gi|7451683|pir||D64563_43:203 ; 152 gi|7521421|pir||D71289_72:203 ; 153 gi|7462295|pir||G72233_8:156 ; 154 gi|7471305|pir||A75470_24:174 ; 155 gi|586817|sp|P37487|PPAC_BACSU_2:149 ; 156 gi|8134643|sp|P95765|PPAC_STRGC_3:152 ; 157 gi|7448978|pir||D69503_154:303 ; 158 gi|3025197|sp|Q59027|YG33_METJA_162:310 ; 159 gi|7518694|pir||B71167_14:164 ; 160 gi|9656203|gb|AAF94837.1|_2:147 ; 161 gi|7450705|pir||G69341_15:161 ; 162 gi|6899406|gb|AAF30828.1|AE002139_1_16:164 ; 163 gi|7483398|pir||C69286_6:130 ; 164 gi|7462978|pir||B72344_4:145 ; 165 gi|7516499|pir||D72622_12:166 ; 166 gi|2833617|sp|Q58241|Y831_METJA_20:167 ; 167 gi|8134641|sp|O29502|PPAC_ARCFU_5:161 ; 168 gi|7451682|pir||B71946_42:203 ; 169 gi|7518105|pir||C75065_14:164 ; 170 gi|7464457|pir||B64650_4:141 ; 171 gi|7475203|pir||A69893_4:125 ; 172 gi|7464707|pir||D71937_3:132 ; 173 gi|7518174|pir||C75097_3:125 ; 174 gi|80890|pir||JQ0091_7:100 ; 175 gi|8134645|sp|Q9RRB7|PPAC_DEIRA_4:147 ; 176 gi|2496072|sp|Q58025|PPAC_METJA_4:148 ; 177 gi|80899|pir||JS0068_5:89 ; 178 gi|7520820|pir||D70337_13:143 10 20 30 40 5 | | | | 1 .......AVLDGRPIIIRHHA--DTDGYCGGIALEKAILPIidkfai..D.VDAIWHFFKR--RP 2 .......AVYDGRSILVRHHA--DADGICAGVAIEKAVLPLlrdlnp..S.TDAEWHYFKR--AP 3 .......AIFEGRPIILRHHA--DTDGYTAGVALETAIVPLieevap..D.PDARWHLFKR--RP 4 .......AIYESRPVIIRHHW--DADGTCGGVALEKALTDLvervhs..D.SEAKYYLVKR--RV 5 rs.....--YAGGGVTVVHHN--DADGLCSGALLKKLCEYC........G.FEAELICIEK---- 6 i......-LNHYGYIRVITHH--DTDGLSSGGILAKMLMRT........N.KLFHLTVVEHLSKE 7 .......HLERGNIIRIISHN--DADGLSAAGVVARAISSM........N.GQFHISILSRLKKE 8 .......HIELGHTIRIISHR--DADGITSAAILAKALARE........G.AKFHISIVKQ---- 9 l......-VARHDFIRIYTHH--DADGISAGAIIAKALLKA........G.KAFHITFLKGLNEP 10 r......-ILKNEEVLVVTHI--DADGITAGTIAHTSLLRA........G.VESGIRFVKQLDES 11 qn.....--NKNNKILIVTHI--DTDGLTSRAILQKLAERL........N.LDADFMFLKQ---- 12 m......-VESSETVTVYSHT--DCDGITAATVLSKVLERL........D.MDHEVRIININEVP 13 mismn..--------LIIHHW--DTDGITSAALLIKALELD........E.FRNMSPPIGE---- 14 a......-MRTNTEILVVGDY--DADGVISSAIMAKFFESL........NyKHVRIAIPNRFMDG 15 .......AIVNSQQICIFADY--DVDGATSAALLKHFLRDL........N.IICDIYVPDRIYEG 16 .......AISQQEKIMIYGDY--DADGVTSTSVMLHTLQKL........S.AQVDFYIPDRFKEG 17 a......-FREGTRIIVVGDF--DADGATSTALSVLAMRSL........GcSNIDYLVPNRFEDG 18 .......ALADNRRIVIVGDF--DADRATSTALTVLALRSM........AaREVQYLVPNRFEDG 19 ay.....--QPQQKIVIVGDF--DADGATSTALSVLALRQL........GfSDVDYLVPNRFEQG 20 .......AIKNNENILIFGDK--DADGITATIIMYETLKDF........G.LNVSYKIPSN-GEF 21 a......-RDRKEHVMIYGDS--DVDGMTGVALLVEFLRDI........D.VHVSYFFLGAILKQ 22 .......AKERNEHVMVYGDS--DVDGMTGVALLVEFLRSI........D.MKVSYCFLGALLKH 23 a......-KANNEHVMIYGDG--DVDGITGVTLIVEFLQIL........G.VKTSYCCSGTLFKQ 24 .......AVLKKKRIIIYGDY--DVDGITGTAILYRVLKLL........G.AKVYPVLPNR-QTG 25 .......AMAQKEKVTIWGDF--DADGITSTAVLWEGLGQFfpq.....D.SQLTYTIPNRLRES 26 .......AHERKEKVLIFGDR--DADGISATTLLFEALCAF........G.LTVCWRVPVA-DEP 27 .......HLNNKNKLFVQVDS--DVDGYTSSSIIINYIKKI........C.PKANIHYRIQDGKE 28 .......EAKQHRPIVFYTDN--DCDGMLAGSVLMSMCYRL........GiKDFFFFSPLRNAHG 29 mvcpkvv----------ILSEGADLDSLSAAYGVLK----L........Y.PDAYLLKPKHLSKK 30 i......-VTESSNVIIMGHKFPDMDSIGAAIGILKVAQAN........N.KDGFIVIDPNQIGS 31 kl.....--KTFDNFSLYVHVNPDFDAFGAAFAFKAFLAVY........F.PHKKAYVMGS--HN 32 ti.....--SLYDTIILHRHVRPDPDAYGSQCGLTEILRET........Y.PEKNIFAVGTPEPS 33 .......AIKQFDKIVIFHHVRPDGDCLGAQQGLFHLIKAN........F.KNKEVKCVGN--NN 34 .......AIQAHDKIVIFHHIRPDGDCLGAQHGLARLIQTN........F.PHKQVFCVGD--PK 35 lk.....--NVKGSILILTHENPDGDSLGSGLALYKFLKKK........G.KEVYIGSKDGVPHF 36 .......FIKKYNNFVIIGHKDPDFDCIGSSLALSSFLSRI........G.KNSILLNEGPFIRK 37 f......-IDAHRAFAVVGHEKPDGDCVGSSLALASFLRRI........G.KEVELLSAGPFKRR 38 llsaa..-----ARVGVVCHVHPDADTIGAGLALALVLDGC........G.KRVEVSFAAPATLP 39 gh.....---QGQRLILVIQDFPDPDALSSAWAFQLIAAQY........E.IQCDIVYAGTLSHQ 40 ee.....--EKKAPLLILTHINPDPDAIASAMALKTLAERW........G.VDSDIAYGGNIGYD 41 e......-SLRGKRLGIFTHDNPDPDSMSSAYALREIAKQF........D.VIADILYYGEILHQ 42 i......-KEKTDTLLIVMHDNPDPDCMASASALAVIAQSI........G.LKTQIVYGGDITHH 43 l......--NRDEGIILLCHHNADPDSLGSAIAFSNFLLSK........G.FSRIRIGVAQSIAS 44 e......-YLKRDEVLFLCHHNADPDAVGSCVALKYLASQL........N.PNGKFRISADSVSK 45 .......EIAIHGSFLLLGHEHPDEDCIASLVAFALLLTRC........N.KRVEICCQGPIRVQ 46 q......-------VYHLSHI--DLDGYACQLVSKQFFKNI........Q.-----CYNANYGRE 47 myh....---------LYSHN--DLDGVGCGIVAKLA---F........G.KDVEIRYNSV--NG 48 .......AVLDGRPIIIRHHA--DTDGYCGGIALEKAILPIidkfai..D.VDAIWHFFKR--RP 49 .......AVYDGRSILVRHHA--DADGICAGVAIEKAVLPLlrdlnp..S.TDAEWHYFKR--AP 50 .......AIFEGRPIILRHHA--DTDGYTAGVALETAIVPLieevap..D.PDARWHLFKR--RP 51 .......AIYESRPVIIRHHW--DADGTCGGVALEKALTDLvervhs..D.SEAKYYLVKR--RV 52 rs.....--YAGGGVTVVHHN--DADGLCSGALLKKLCEYC........G.FEAELICIEK---- 53 i......-LNHYGYIRVITHH--DTDGLSSGGILAKMLMRT........N.KLFHLTVVEHLSKE 54 .......HLERGNIIRIISHN--DADGLSAAGVVARAISSM........N.GQFHISILSRLKKE 55 .......HIELGHTIRIISHR--DADGITSAAILAKALARE........G.AKFHISIVKQ---- 56 l......-VARHDFIRIYTHH--DADGISAGAIIAKALLKA........G.KAFHITFLKGLNEP 57 r......-ILKNEEVLVVTHI--DADGITAGTIAHTSLLRA........G.VESGIRFVKQLDES 58 qn.....--NKNNKILIVTHI--DTDGLTSRAILQKLAERL........N.LDADFMFLKQ---- 59 m......-VESSETVTVYSHT--DCDGITAATVLSKVLERL........D.MDHEVRIININEVP 60 mismn..--------LIIHHW--DTDGITSAALLIKALELD........E.FRNMSPPIGE---- 61 a......-MRTNTEILVVGDY--DADGVISSAIMAKFFESL........NyKHVRIAIPNRFMDG 62 .......AIVNSQQICIFADY--DVDGATSAALLKHFLRDL........N.IICDIYVPDRIYEG 63 .......AISQQEKIMIYGDY--DADGVTSTSVMLHTLQKL........S.AQVDFYIPDRFKEG 64 a......-FREGTRIIVVGDF--DADGATSTALSVLAMRSL........GcSNIDYLVPNRFEDG 65 .......ALADNRRIVIVGDF--DADRATSTALTVLALRSM........AaREVQYLVPNRFEDG 66 ay.....--QPQQKIVIVGDF--DADGATSTALSVLALRQL........GfSDVDYLVPNRFEQG 67 .......AIKNNENILIFGDK--DADGITATIIMYETLKDF........G.LNVSYKIPSN-GEF 68 a......-RDRKEHVMIYGDS--DVDGMTGVALLVEFLRDI........D.VHVSYFFLGAILKQ 69 .......AKERNEHVMVYGDS--DVDGMTGVALLVEFLRSI........D.MKVSYCFLGALLKH 70 a......-KANNEHVMIYGDG--DVDGITGVTLIVEFLQIL........G.VKTSYCCSGTLFKQ 71 .......AVLKKKRIIIYGDY--DVDGITGTAILYRVLKLL........G.AKVYPVLPNR-QTG 72 .......AMAQKEKVTIWGDF--DADGITSTAVLWEGLGQFfpq.....D.SQLTYTIPNRLRES 73 .......AHERKEKVLIFGDR--DADGISATTLLFEALCAF........G.LTVCWRVPVA-DEP 74 .......HLNNKNKLFVQVDS--DVDGYTSSSIIINYIKKI........C.PKANIHYRIQDGKE 75 .......EAKQHRPIVFYTDN--DCDGMLAGSVLMSMCYRL........GiKDFFFFSPLRNAHG 76 mvcpkvv----------ILSEGADLDSLSAAYGVLK----L........Y.PDAYLLKPKHLSKK 77 i......-VTESSNVIIMGHKFPDMDSIGAAIGILKVAQAN........N.KDGFIVIDPNQIGS 78 kl.....--KTFDNFSLYVHVNPDFDAFGAAFAFKAFLAVY........F.PHKKAYVMGS--HN 79 ti.....--SLYDTIILHRHVRPDPDAYGSQCGLTEILRET........Y.PEKNIFAVGTPEPS 80 .......AIKQFDKIVIFHHVRPDGDCLGAQQGLFHLIKAN........F.KNKEVKCVGN--NN 81 .......AIQAHDKIVIFHHIRPDGDCLGAQHGLARLIQTN........F.PHKQVFCVGD--PK 82 lk.....--NVKGSILILTHENPDGDSLGSGLALYKFLKKK........G.KEVYIGSKDGVPHF 83 .......FIKKYNNFVIIGHKDPDFDCIGSSLALSSFLSRI........G.KNSILLNEGPFIRK 84 f......-IDAHRAFAVVGHEKPDGDCVGSSLALASFLRRI........G.KEVELLSAGPFKRR 85 llsaa..-----ARVGVVCHVHPDADTIGAGLALALVLDGC........G.KRVEVSFAAPATLP 86 gh.....---QGQRLILVIQDFPDPDALSSAWAFQLIAAQY........E.IQCDIVYAGTLSHQ 87 ee.....--EKKAPLLILTHINPDPDAIASAMALKTLAERW........G.VDSDIAYGGNIGYD 88 e......-SLRGKRLGIFTHDNPDPDSMSSAYALREIAKQF........D.VIADILYYGEILHQ 89 i......-KEKTDTLLIVMHDNPDPDCMASASALAVIAQSI........G.LKTQIVYGGDITHH 90 l......--NRDEGIILLCHHNADPDSLGSAIAFSNFLLSK........G.FSRIRIGVAQSIAS 91 e......-YLKRDEVLFLCHHNADPDAVGSCVALKYLASQL........N.PNGKFRISADSVSK 92 .......EIAIHGSFLLLGHEHPDEDCIASLVAFALLLTRC........N.KRVEICCQGPIRVQ 93 q......-------VYHLSHI--DLDGYACQLVSKQFFKNI........Q.-----CYNANYGRE 94 myh....---------LYSHN--DLDGVGCGIVAKLA---F........G.KDVEIRYNSV--NG 95 .......AKERNEHVMVYGDS--DVDGMTGVALLVEFLRSI........D.MKVSYCFLGALLKH 96 .......AISQQEKIMIYGDY--DADGVTSTSVMLHTLQKL........S.AQVDFYIPDRFKEG 97 .......-KANNEHVMIYGDG--DVDGITGVTLIVEFLQIL........G.VKTSYCCSGTLFKQ 98 .......AVGRKEKILIVADY--DADGATACAVGMSGLAAM........G.AKVDFLVPNRFEHG 99 .......-FREGTRIIVVGDF--DADGATSTALSVLAMRSL........GcSNIDYLVPNRFEDG 100 .......AIAEQKRIIVVGDF--DADGATSSALSVLALRML........GsRNVDYLVPNRFEDG 101 .......-FREGTRIIVVGDF--DADGATSTALSVLAMRSL........GcSNIDYLVPNRFEDG 102 .......--QPQQKIVIVGDF--DADGATSTALSVLALRQL........GfSDVDYLVPNRFEQG 103 .......ALADNRRIVIVGDF--DADRATSTALTVLALRSM........AaREVQYLVPNRFEDG 104 .......-RDRKEHVMIYGDS--DVDGMTGVALLVEFLRDI........D.VHVSYFFLGAILKQ 105 .......AIVNSQQICIFADY--DVDGATSAALLKHFLRDL........N.IICDIYVPDRIYEG 106 .......AVLDGRPIIIRHHA--DTDGYCGGIALEKAILPIidkfai..D.VDAIWHFFKR--RP 107 .......AVERQEKILIVADY--DADGATACAVGLDGLAAM........G.AKVDFLVPNRFEHG 108 .......AIQAHDKIVIFHHIRPDGDCLGAQHGLARLIQTN........F.PHKQVFCVGD--PK 109 .......-RSKNELVLIHGDY--DVDGITSTVMLKEFLEEN........G.WRVDVYIPHRIEEG 110 .......FIKKYNNFVIIGHKDPDFDCIGSSLALSSFLSRI........G.KNSILLNEGPFIRK 111 .......AVYDGRSILVRHHA--DADGICAGVAIEKAVLPLlrdlnp..S.TDAEWHYFKR--AP 112 .......--ENNEHVMIYGDG--DVDGITGVTLLVEFLQML........G.VKTSYCCSGTLFKQ 113 .......AIYESRPVIIRHHW--DADGTCGGVALEKALTDLvervhs..D.SEAKYYLVKR--RV 114 .......AIAAQRRILVVGDF--DCDGATACAVGVRGLRML........GaLDVHHAVPNRMVHG 115 .......AIKQFDKIVIFHHVRPDGDCLGAQQGLFHLIKAN........F.KNKEVKCVGN--NN 116 .......--NKNNKILIVTHI--DTDGLTSRAILQKLAERL........N.LDADFMFLKQ---- 117 .......AVERKEKILIVADY--DADGATACAVGLDGLAAM........G.AKVDFLVPNRFEHG 118 .......-IKANGRILVVGDF--DCDGATACAVAVRGLRLL........GaRNVMHAVPNRMVHG 119 .......AIKNNENILIFGDK--DADGITATIIMYETLKDF........G.LNVSYKIPSN-GEF 120 .......AVLKKKRIIIYGDY--DVDGITGTAILYRVLKLL........G.AKVYPVLPNR-QTG 121 .......AIKNNENILIFGDK--DADGITATIIMYETLKDF........G.LNVSYKIPSN-GEF 122 .......AVEKNEKVAIVGDY--DVDGIISCVIMAEFFDDI........G.FDYIIRIPNRFKDG 123 .......---LYDTIILHRHVRPDPDAYGSQCGLTEILRET........Y.PEKNIFAVGTPEPS 124 .......------RVGVVCHVHPDADTIGAGLALALVLDGC........G.KRVEVSFAAPATLP 125 .......AIKNNENILIFGDK--DADGIXATIIMYETLKDF........G.LNVSYXIPSN-GEF 126 .......---QGQRLILVIQDFPDPDALSSAWAFQLIAAQY........E.IQCDIVYAGTLSHQ 127 .......-VKQFDKFSLFVHVNPDFDAFGSAFAFKTFLNTF........F.SEKKAYVMGS--YN 128 .......--KTFDNFSLYVHVNPDFDAFGAAFAFKAFLAVY........F.PHKKAYVMGS--HN 129 .......AIFEGRPIIIRHHA--DTDGYTAGVALETAIVPLieqvap..D.PDARWHLFKR--RP 130 .......AIFEGRPIILRHHA--DTDGYTAGVALETAIVPLieevap..D.PDARWHLFKR--RP 131 .......-KEKTDTLLIVMHDNPDPDCMASASALAVIAQSI........G.LKTQIVYGGDITHH 132 .......EIAIHGSFLLLGHEHPDEDCIASLVAFALLLTRC........N.KRVEICCQGPIRVQ 133 .......HLNNKNKLFVQVDS--DVDGYTSSSIIINYIKKI........C.PKANIHYRIQDGKE 134 .......AVREGKRIRIHGDY--DADGVSATATLVLGLRAI........G.ANVHGFIPHRLNEG 135 .......-IELGHTIRIISHR--DADGITSAAIVAKALARE........G.ADFHVSIVKQ---- 136 .......-IELGHTIRIISHR--DADGITSAAILAKALARE........G.AKFHISIVKQ---- 137 .......-VTESSNVIIMGHKFPDMDSIGAAIGILKVAQAN........N.KDGFIVIDPNQIGS 138 .......--NVKGSILILTHENPDGDSLGSGLALYKFLKKK........G.KEVYIGSKDGVPHF 139 .......-KERTDSLLIVMHDNPDPDSMASASALAVIAQSV........G.LRPQIVYGGDITHH 140 .......-IDAHRAFAVVGHEKPDGDCVGSSLALASFLRRI........G.KEVELLSAGPFKRR 141 .......HLERGNIIRIISHN--DADGLSAAGVVARAISSM........N.GQFHISILSRLK-- 142 .......-VESSETVTVYSHT--DCDGITAATVLSKVLERL........D.MDHEVRIININEVP 143 .......EVKRHRPIIFYTDN--DCDGMLAGSVLMSMCYRL........GiKDFFFFSPLRNAHG 144 .......AMAQKEKVTIWGDF--DADGITSTAVLWEGLGQFfpq.....D.SQLTYTIPNRLRES 145 .......-VARHDFIRIYTHH--DADGISAGAIIAKALLKA........G.KAFHITFLKGLNEP 146 .......--YAGGGVTVVHHN--DADGLCSGALLKKLCEYC........G.FEAELICIEK---- 147 .......------KILVFGHQNPDSDAIGSSMAYAYLKRQL........G.VDAQAVALGNPNEE 148 .......-YLKRDEVLFLCHHNADPDAVGSCVALKYLASQL........N.PNGKFRISADSVSK 149 .......-AKQHRPIVFYTDN--DCDGMLAGSVLMSMCYRL........GiKDFFFFSPLRNAHG 150 .......-AKQHRPIVFYTDN--DCDGMLAGSVLMSMCYRL........GiKDFFFFSPLRNAHG 151 .......-MRTNTEILVVGDY--DADGVISSAIMAKFFESL........NyKHVRIAIPNRFMDG 152 .......AHERKEKVLIFGDR--DADGISATTLLFEALCAF........G.LTVCWRVPVA-DEP 153 .......-LSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKL........G.KEVKAAVDYK---- 154 .......--AHPGPIVVLSHENPDGDALGSVLGLSRALRTL........G.K----TVLAPMTVP 155 .......-----EKILIFGHQNPDTDTICSAIAYADLKNKL........G.FNAEPVRLGQVNGE 156 .......------KILVFGHQNPDSDAIGSSYAFAYLAREAy.......G.LDTEAVALGEPNEE 157 .......--LRGKRLGIFTHDNPDPDSMSSAYALREIAKQF........D.VIADILYYGEILHQ 158 .......--EKKAPLLILTHINPDPDAIASAMALKTLAERW........G.VDSDIAYGGNIGYD 159 .......-LNRDEGIILLCHHNADPDSLGSAIAFSNFLLSK........G.FSRIRIGVAQSIAS 160 .......-------ILVVGHKNPDSDSICSALVAAELLKAR........G.LEAKAVRQGEINRE 161 .......-ILKNEEVLVVTHI--DADGITAGTIAHTSLLRA........G.VESGIRFVKQLDES 162 .......----FNKITIFVHTNPDCDALGSAFALARILKLNtf......G.TRVKIVGVNALNPN 163 .......--------LIIHHW--DTDGITSAALLIKALELD........E.FRNMSPPIGE---- 164 .......---------ITTHRSPDFDAFASCVAAKKLLD--........-.-DHIIVLPSNPARN 165 .......---EGEKSAVITHRNADPDAVGAALVVREVLRAL........R.MNPCLYSPEGISRQ 166 .......-LNHYGYIRVITHH--DTDGLSSGGILAKMLMRT........N.KLFHLTVVEHLSKE 167 .......-------VYVVGHKNPDTDSVCSAIAFAYLWNKWkeg12mkiE.AEAKPVIQGDVNPE 168 .......AMRANTEILVVGDY--DADGVISSAIMAKFFKSL........NyKHVRVAIPNRFMDG 169 .......-LKRDEGIILLCHHNADPDSLGSAIAFSNFLLDR........G.LRNVRIGVAQSIAS 170 .......-------VYHLSHI--DLDGYACQLVSKQFFKNI........Q.-----CYNANYGRE 171 .......---------LYSHN--DLDGVGCGIVAKLA---F........G.KDVEIRYNSV--NG 172 .......-------VYHLSHI--DLDGYACQLVSKQFFKNI........Q.-----CYNANYGRE 173 .......--------LIIHHW--DTDGITSAALLMKKLG--........-.-------------- 174 .......----------------------------------........-.-------------- 175 .......---------VFGHLNPDTDAISAAMVYARLLTRQ........G.TEAQAYRLGEPNFE 176 .......---------VVGHKNPDTDSIASAIVLAYFL---........-.-DCYPARLGDINPE 177 .......----------------------------------........-.-------------- 178 .......---------------ADLDSLSAAYGVLKL----........Y.PDAYLLKPKHLSKK 0 60 70 80 90 | | | | | 1 SKAPFYEL........EDVT........KDLVFSIEDAL...KFGQKLPLI.VLIDN...GSTD. 2 SKAPFYEL........EDVV........KDLSYALEDLE...RHGQKLPLL.VLLDN...GSTE. 3 SRAPFYEL........EDVL........KDIIFMMEDHM...RFGDELPLV.VIVDN...GGTT. 4 SRAPFYEL........EDVV........RDLDESLEDAE...RHGDKIPLV.VLVDN...GSGL. 5 --------........----........---VYPAVVEK...IHSSRDGMI.IYTDL...GG--. 6 VIEKLAKE........NEV-........-----------...----NKPLF.IFADM...GS--. 7 F-------........----........--------IKK...LSGEKYSLF.FFCDM...GS--. 8 --------........----........---VSEELVRQ...LKDEEYKII.IFSDL...GSGS. 9 FEYE----........----........-----------...----QGELL.LFADM...GS--. 10 EIEAIKD-........----........-----------...----ENTFV.WFTDI...GS--. 11 --------........----........---ITIETIND...IPFKDYDLI.IFADL...GSGQl 12 EVEL----........----........-----------...----SSDLT.IFSDL...GS--. 13 --------........----........---FRFDDRIR...KAIEHAERV.YILDL...NLPY. 14 YGISKKFL........EKH-........-----------...----HAPLI.ITVDN...GI--. 15 YGPT----........----........-----PLAMQK...IKGNGTELL.ITVDC...GA--. 16 YGPN----........----........-----EQAFRS...IKERGFSLI.ITVDT...GI--. 17 YGLS----........----........-----PEVVDQ...AHARGAQLI.VTVDN...GI--. 18 YGLS----........----........-----PEVVAQ...APAKGAELI.VTVDN...GI--. 19 YGLS----........----........-----IPVAEM...AIEKGVQLL.MTVDN...GV--. 20 YGLS----........----........-----NELINT...ALEKKISLI.ITVDN...GI--. 21 HGET----........----........-----STLIAK...LKEEGITLL.ITVDC...GI--. 22 YGEP----........----........-----SSLIAK...MKEEKVTLL.ITVDC...GI--. 23 HGET----........----........-----ASLISQ...MLQDGISLL.ITVDC...GI--. 24 YGLN----........----........------KELMS...IFEKYGDFL.ITVDN...GT--. 25 HGLNRPGL........ERL-........-----------...-ATQGTKLI.VTCDT...GS--. 26 YGLS----........----........-----CNAVDE...HAAAGGTLI.VTVDC...GI--. 27 HGIF----........----........---------ID...TIPDDVDLV.IIPDA...GS--. 28 YGFTDLAL........NDLLsqp9fnpkTNQLVRLDCIK...NQFQKNPLL.FSADL...GADLa 29 AGEVFKKY........RDK-........------FRVIE...DLPDCFE-L.VLVDT...HF--. 30 SVQRLIGE........IKKY........EELWSRFITPEeamEISNDDTLL.VIVDT...HK--. 31 IKADGKDL........FPF-........-----EAAPID...DAFVKNSLA.IIFDT...S---. 32 LSFL----........----........----YSLDEVD...NETYEGALV.IVCDT...A---. 33 NLFSFINM........TF--........------TNQID...ESFLKEALA.IVVDA...NYKN. 34 HNFPWLEM........VFTP........KEQITPELM--...----QQALA.VIVDA...NYKE. 35 LDFL----........----........---PGVEDVIN...PDGKFYDVG.IVVDA...SG--. 36 EIVPFKD-........----........---KFLSEWPN...IEISEYS-V.IILDC...SI-L. 37 EIAAYATL........FR--........-----PSLSAQ...IRPSDQTAV.IVVDC...SE-L. 38 ESLRSLPG........CHL-........------LVRPE...VMRRDVDLV.VTVDI...PS-V. 39 ENIALVKL........TGLP........AKRWGPQMLKD...IDLSDYQGC.VLVDS...QGTN. 40 ENKAMINL........LGI-........----KLLNVED...IDLDNYCVI.AVIDT...ST--. 41 KNRAMVNL........LEI-........----PMIRAPE...VDLSHYDAF.AIVDS...SG--. 42 QNRAMVNV........LGME........FRKVSR---GS...YEIKRHKAI.AIVDA...QP--. 43 YSRRLVAL........SRVP........IEKDPVI----...----KENVI.FIFDT...SS--. 44 LSRNILNE........IG--........-----ERVDIE...IYPKLPETV.FIVDT...AS--. 45 ISFL---I........DICL........YNGIAVHLDTQ...TVPRMPDAL.VILDTpnpGMIY. 46 VSARIYEI........LNA-........---------IA...QSKESEFLI.LVSDL...NLNL. 47 LNAQ----........----........---VQYFLEKA...KESNRQDAL.FITDL...AVNE. 48 SKAPFYEL........EDVT........KDLVFSIEDAL...KFGQKLPLI.VLIDN...GSTD. 49 SKAPFYEL........EDVV........KDLSYALEDLE...RHGQKLPLL.VLLDN...GSTE. 50 SRAPFYEL........EDVL........KDIIFMMEDHM...RFGDELPLV.VIVDN...GGTT. 51 SRAPFYEL........EDVV........RDLDESLEDAE...RHGDKIPLV.VLVDN...GSGL. 52 --------........----........---VYPAVVEK...IHSSRDGMI.IYTDL...GG--. 53 VIEKLAKE........NEV-........-----------...----NKPLF.IFADM...GS--. 54 F-------........----........--------IKK...LSGEKYSLF.FFCDM...GS--. 55 --------........----........---VSEELVRQ...LKDEEYKII.IFSDL...GSGS. 56 FEYE----........----........-----------...----QGELL.LFADM...GS--. 57 EIEAIKD-........----........-----------...----ENTFV.WFTDI...GS--. 58 --------........----........---ITIETIND...IPFKDYDLI.IFADL...GSGQl 59 EVEL----........----........-----------...----SSDLT.IFSDL...GS--. 60 --------........----........---FRFDDRIR...KAIEHAERV.YILDL...NLPY. 61 YGISKKFL........EKH-........-----------...----HAPLI.ITVDN...GI--. 62 YGPT----........----........-----PLAMQK...IKGNGTELL.ITVDC...GA--. 63 YGPN----........----........-----EQAFRS...IKERGFSLI.ITVDT...GI--. 64 YGLS----........----........-----PEVVDQ...AHARGAQLI.VTVDN...GI--. 65 YGLS----........----........-----PEVVAQ...APAKGAELI.VTVDN...GI--. 66 YGLS----........----........-----IPVAEM...AIEKGVQLL.MTVDN...GV--. 67 YGLS----........----........-----NELINT...ALEKKISLI.ITVDN...GI--. 68 HGET----........----........-----STLIAK...LKEEGITLL.ITVDC...GI--. 69 YGEP----........----........-----SSLIAK...MKEEKVTLL.ITVDC...GI--. 70 HGET----........----........-----ASLISQ...MLQDGISLL.ITVDC...GI--. 71 YGLN----........----........------KELMS...IFEKYGDFL.ITVDN...GT--. 72 HGLNRPGL........ERL-........-----------...-ATQGTKLI.VTCDT...GS--. 73 YGLS----........----........-----CNAVDE...HAAAGGTLI.VTVDC...GI--. 74 HGIF----........----........---------ID...TIPDDVDLV.IIPDA...GS--. 75 YGFTDLAL........NDLLsqp9fnpkTNQLVRLDCIK...NQFQKNPLL.FSADL...GADLa 76 AGEVFKKY........RDK-........------FRVIE...DLPDCFE-L.VLVDT...HF--. 77 SVQRLIGE........IKKY........EELWSRFITPEeamEISNDDTLL.VIVDT...HK--. 78 IKADGKDL........FPF-........-----EAAPID...DAFVKNSLA.IIFDT...S---. 79 LSFL----........----........----YSLDEVD...NETYEGALV.IVCDT...A---. 80 NLFSFINM........TF--........------TNQID...ESFLKEALA.IVVDA...NYKN. 81 HNFPWLEM........VFTP........KEQITPELM--...----QQALA.VIVDA...NYKE. 82 LDFL----........----........---PGVEDVIN...PDGKFYDVG.IVVDA...SG--. 83 EIVPFKD-........----........---KFLSEWPN...IEISEYS-V.IILDC...SI-L. 84 EIAAYATL........FR--........-----PSLSAQ...IRPSDQTAV.IVVDC...SE-L. 85 ESLRSLPG........CHL-........------LVRPE...VMRRDVDLV.VTVDI...PS-V. 86 ENIALVKL........TGLP........AKRWGPQMLKD...IDLSDYQGC.VLVDS...QGTN. 87 ENKAMINL........LGI-........----KLLNVED...IDLDNYCVI.AVIDT...ST--. 88 KNRAMVNL........LEI-........----PMIRAPE...VDLSHYDAF.AIVDS...SG--. 89 QNRAMVNV........LGME........FRKVSR---GS...YEIKRHKAI.AIVDA...QP--. 90 YSRRLVAL........SRVP........IEKDPVI----...----KENVI.FIFDT...SS--. 91 LSRNILNE........IG--........-----ERVDIE...IYPKLPETV.FIVDT...AS--. 92 ISFL---I........DICL........YNGIAVHLDTQ...TVPRMPDAL.VILDTpnpGMIY. 93 VSARIYEI........LNA-........---------IA...QSKESEFLI.LVSDL...NLNL. 94 LNAQ----........----........---VQYFLEKA...KESNRQDAL.FITDL...AVNE. 95 YGEP----........----........-----SSLIAK...MKEEKVTLL.ITVDC...GI--. 96 YGPN----........----........-----EQAFRS...IKERGFSLI.ITVDT...GI--. 97 HGET----........----........-----ASLISQ...MLQDGISLL.ITVDC...GI--. 98 YGLT----........----........-----PELAEI...AAAQGVDLL.ITVDN...GI--. 99 YGLS----........----........-----PEVVDQ...AHARGAQLI.VTVDN...GI--. 100 YGLS----........----........-----PEVVDQ...AIERGAEMI.MTVDN...GV--. 101 YGLS----........----........-----PEVVDQ...AHARGAQLI.VTVDN...GI--. 102 YGLS----........----........-----IPVAEM...AIEKGVQLL.MTVDN...GV--. 103 YGLS----........----........-----PEVVAQ...APAKGAELI.VTVDN...GI--. 104 HGET----........----........-----STLIAK...LKEEGITLL.ITVDC...GI--. 105 YGPT----........----........-----PLAMQK...IKGNGTELL.ITVDC...GA--. 106 SKAPFYEL........EDVT........KDLVFSIEDAL...KFGQKLPLI.VLIDN...GSTD. 107 YGLT----........----........-----PELAEI...AAAQGVDLL.ITVDN...GI--. 108 HNFPWLEM........VFTP........KEQITPELM--...----QQALA.VIVDA...NYKE. 109 YGIQ----........----........-----PENIST...FKENNVSCL.VTVDC...GI--. 110 EIVPFKD-........----........---KFLSEWPN...IEISEYS-V.IILDC...SI-L. 111 SKAPFYEL........EDVV........KDLSYALEDLE...RHGQKLPLL.VLLDN...GSTE. 112 HGEI----........----........-----TSLISQ...MLQDGVSLL.ITVDC...GI--. 113 SRAPFYEL........EDVV........RDLDESLEDAE...RHGDKIPLV.VLVDN...GSGL. 114 YGLS----........----........-----PALVDE...LAALQPDLL.VTVDH...GI--. 115 NLFSFINM........T---........-----FTNQID...ESFLKEALA.IVVDA...NYKN. 116 --------........----........---ITIETIND...IPFKDYDLI.IFADL...GSGQl 117 YGLT----........----........-----PELAEI...AAAQGVDLL.ITVDN...GI--. 118 YGLS----........----........-----SALVEE...LAPLQPALL.VTVDH...GI--. 119 YGLS----........----........-----NELINT...ALEKKISLI.ITVDN...GI--. 120 YGLN----........----........------KELMS...IFEKYGDFL.ITVDN...GT--. 121 YGLS----........----........-----NELINT...ALEKKISLI.ITVDN...GI--. 122 YGLN----........----........-----AEIINE...---LDVNLI.ITVDN...GI--. 123 LSFL----........----........----YSLDEVD...NETYEGALV.IVCDT...A---. 124 ESLR----........---S........LPGCHLLVRPE...VMRRDVDLV.VTVDI...PS-V. 125 YGLS----........----........-----NELINT...ALEKKISLI.ITVDN...GI--. 126 ENIALVKL........TGLP........AKRWGPQMLKD...IDLSDYQGC.VLVDS...QGTN. 127 INADGREL........FPF-........-----EQTDIN...DDFVKESLA.IIFDT...S---. 128 IKADGKDL........FPF-........-----EAAPID...DAFVKNSLA.IIFDT...S---. 129 SRAPFYEL........EDVL........KDIIFMMEDHQ...RFGDELPLI.VIVDN...GGTS. 130 SRAPFYEL........EDVL........KDIIFMMEDHM...RFGDELPLV.VIVDN...GGTT. 131 QNRAMVNV........LGME........FR---KVSRGS...YEIKRHKAI.AIVDA...QP--. 132 ISFL---I........DICL........YNGIAVHLDTQ...TVPRMPDAL.VILDTpnpGMIY. 133 HGIF----........----........---------ID...TIPDDVDLV.IIPDA...GS--. 134 YGIH----........----........------PDRVP...EHAAAADLV.VTVDC...GV--. 135 --------........----........---VSEDLVRQ...LKDEDYKVF.IFSDL...GSGS. 136 --------........----........---VSEELVRQ...LKDEEYKII.IFSDL...GSGS. 137 SVQRLIGE........IKKY........EELWSRFITPEeamEISNDDTLL.VIVDT...HK--. 138 LDFL----........----........---PGVEDVIN...PDGKFYDVG.IVVDA...SGFY. 139 QNRAMVNV........LGME........---FKKVLRGS...YEIKRYDAI.AIVDA...QP--. 140 EIAA----........---Y........ATLFRPSLSAQ...IRPSDQTAV.IVVDC...SE-L. 141 --------........----........-----KEFIKK...LSGEKYSLF.FFCDM...GS--. 142 EVEL----........----........-----------...----SSDLT.IFSDL...GS--. 143 YGFTDLALndl9qlciFNPK........TNQLVRLDYIK...NQFQKTPLL.FSADL...GADLv 144 HGLN----........----........-----RPGLER...LATQGTKLI.VTCDT...GS--. 145 FEYE----........----........-----------...----QGELL.LFADM...GS--. 146 --------........----........---VYPAVVEK...IHSSRDGMI.IYTDL...GG--. 147 TAFV-LD-........---Y........FGIQAPPVVKS...AQAEGAKQV.ILTDH...NEFQ. 148 LSRN----........---I........LNEIGERVDIE...IYPKLPETV.FIVDT...AS--. 149 YGFTDLALndl9qpciFNPK........TNQLVRLDCIK...NQFQKNPLL.FSADL...GADLa 150 YGFTDLALndl9qpciFNPK........TNQLVRLDCIK...NQFQKNPLL.FSADL...GADLa 151 YGISKKFL........EKH-........-----------...----HAPLI.ITVDN...GI--. 152 YGLS----........----........-----CNAVDE...HAAAGGTLI.VTVDC...GI--. 153 -------I........PYVF........EKFPYIDKIEE...NPNFDPELL.VVVDA...SSPD. 154 HYLS----........---F........LPQPGELTAPL...ESWPQGALA.AVLDV...DNND. 155 TQYA-LDY........FK--........---QESPRLVE...TAANEVNGV.ILVDH...NERQ. 156 TAFV-LD-........---Y........FGVAAPRVITS...AKAEGAEQV.ILTDH...NEFQ. 157 KNRAMVNL........LE--........---IPMIRAPE...VDLSHYDAF.AIVDS...SG--. 158 ENKAMINL........LG--........---IKLLNVED...IDLDNYCVI.AVIDT...ST-S. 159 YSRRLVAL........SRVP........IEKDPVI----...----KENVI.FIFDT...SS--. 160 TQHI-LN-........---V........AGVEQPELRTS...VAGEQVWLV.DYTDL...A---. 161 EIEAIKD-........----........-----------...----ENTFV.WFTDI...GS--. 162 DFKNFFT-........----........---FDPNEVDD...EFIKD-SIA.FIVDT...A---. 163 --------........----........---FRFDDRIR...KAIEHAERV.YILDL...NLPY. 164 LSDFLK--........---V........YSDRFEFVWDH...EFEGEITEL.VIVDA...PS-L. 165 SKRL----........LEAV........GEEFGPLCSPD...----ENPLIaVVVDA...ANLS. 166 VIEKLAKE........NEV-........-----------...----NKPLF.IFADM...GS--. 167 TKYVLEK-........----........FGFEVPEIMTN...G---EGKKV.ALVDH...SEKA. 168 YGISKKFL........EKH-........-----------...----HAPLI.ITVDN...GI--. 169 YSRRLLKF........SRV-........------PIERN...PKI-SERVV.FIFDT...SS-L. 170 VSARIYEI........LNA-........---------IA...QSKESEFLI.LVSDL...NLNL. 171 LNAQ----........----........---VQYFLEKA...KESNRQDAL.FITDL...AVNE. 172 VSARIYEI........LNA-........---------IA...QSKESEFLI.LVSDL...NLNL. 173 --EDFENL........TG-P........IGEFRFDDRIW...KEIERAEEI.YVVDF...NV--. 174 --------........----........---------ID...ESFLKEALA.IVVDA...NYKN. 175 TAYVLREL........----........-GLEAPPLLTE...LPAG--SKV.ALVDH...NESA. 176 TEFVLRK-........----........---FGVMEPEL...IESAKGKEI.ILVDH...SEKS. 177 --------........----........-----------...-------LA.VIVDA...NYKE. 178 AGEVFKKY........RDK-........---FRVIEDLP...----DCFEL.VLVDT...HFLP. 100 110 120 130 14 | | | | 1 ...E......DIPAISKAKAYGIEV.IVIDHH.FPGEVVDgkv.EVDDYVDAHVNPYLVGG.DSN 2 ...E......DILALMKAKIYDIEI.VVVDHH.YPGEVQDgrv.EVDEYVDTHVNPYLVGG.DSQ 3 ...E......DIPAYKRLKAYGVKI.VVIDHH.DPRDWISedkaKVDEYVDVHVNPHH---.--- 4 ...E......DVPAIRQFLLFGADV.ITIDHH.FPDE---....EVDSYLLYHVNPYKVGG.DSN 5 ...L......AADMIDKINAGKSMV.LIIDHH.PAKD---....-IDSDYVHVLDPELAGI.SGD 6 ...-......--GQIEEIIKHNFNA.IILDHH.PPVIKDS....F-INENIIQLNPHIFGV.DGS 7 ...-......--AYLEEISRLKGDV.IVADHH.QPSE---....SEAGPHVVHINPHLHGL.DGS 8 ...L......SLIGEHL---KDKSV.VILDHH.PPEP---....VETHEKHILANPVQFGA.NSV 9 ...-......--GYADLISQVDTDV.VILDHH.IPNG--E....IRPKRNLAHVNPHLVGM.DGT 10 ...-......----GVLNMLDGIEF.AITDHH.LPQS---....----HHPMQLNPHDFGY.DGA 11 kmiK......EKLDELNLSDKRDKI.IILDHH.QPEE---....IKIPKTIIHINPLTIAK.SGA 12 ...-......-GQRVHENLKSNSRV.LILDHH.PPVRKMNf...TAPSGDFLEINPIFYGM.DGS 13 ...D......VEGIE-------KET.VFIDHH.IQPK---....-IKNPRVRQINPSLEGKeSPS 14 ...N......AFEAARFCKEKNYTL.IITDHH.CLHH---....DEVPDAYAVINPKQ---.-PD 15 ...M......AHDALKYAKDVKLDV.IVIDHH.ISTE---....-ILPDAVAIVNPNR---.-ID 16 ...A......AVHEAKVAKELGLDV.IITDHH.EPGP---....-ELPDVRAIVHPKQ---.-PG 17 ...S......SHAGVEHARSLGIPV.IVTDHH.LPGD---....-TLPAAEAIINPNL---.-RD 18 ...S......SHAGVDDAHRRGIAV.VVTDHH.LPGE---....-TLPAAEAMINPNL---.-SD 19 ...S......SFDGVAFLKEKGIRV.LVTDHH.LPPE---....-TLPPADAIVNPNL---.-SQ 20 ...S......SIEEINYANSKGIEI.IITDHH.LPGE---....-NFKTENIVINPHL---.-KD 21 ...T......AGKEVSDITRQGIDV.IITDHH.MPTG---....-KIPHCVATLNPKL---.-RD 22 ...T......AGKEVSDINKQGIDV.IITDHH.MPTG---....-KIPHCIATLNPKL---.-RD 23 ...T......AGKEVHAINKQGIDV.IVTDHH.MPTG---....-KLPHCVAMLNPKL---.-DK 24 ...-......--SAVEEIDQSSLET.VVIDHH.NVPP---....-RIPKKALIVNPKV---.-GA 25 ...T......NLDEIVYAQQLGMDV.IVTDHH.TLPD---....-DRPEVVAIINPRY---.-FA 26 ...S......NRAEIAYARHRGIDV.LVIDHH.AAPE---....--TLPDAIIINAKV---.-PG 27 ...S......QFEEHEALNKRGTEI.IVIDHH.ECER---....--VSEHAIVVNNQL---.--S 28 ...A......NTELQEILLEHFEQC.IITDHH.KSFE-VD....WIDENKIAYINLND---.-EK 29 ...-......--LPEGLPRERIKRI.IVYDHH.PIGD---....--VKEFEGKIEKV----.-GA 30 ...P......SLVMEERLVNKIEHI.VVIDHH.RRGE--E....FIRDPLLVYMEPYA---.-SS 31 ...N......QERVLTQKHKLAKET.VRIDHH.PKTE---....--SFADLEWIDPAF---.-SA 32 ...N......QERIDDQRYPSGAKL.MKIDHH.PNED---....--PYGDLLWVDTSA---.-SS 33 ...R......IELRELLDKNLFKAV.LRIDHH.PNED---....-DLNTSFNFVEESY---.-VA 34 ...R......IECRDLLDQNQFKAV.LRIDHH.PNED---....-DLNTTHNFVDASY---.-IA 35 ...-......--FYRVGKEVKVGKR.IRIDHH.VGGE---....--FYGMHDYIDPTA---.-PA 36 ...D......RIGDEFIFYVKNMPT.LVIDHH.MSGE---....--KLECEGYIDPFA---.-PS 37 ...S......RVGAELASQLAPFAR.AFIDHH.ETCG---....--DHCAHSFVVKTA---.-PS 38 ...D......RLGALGDLTDSGREL.LVIDHH.ASND---....--LFGTANFIDPSA---.-DS 39 ...S......QLMPLVQEANIPV-V.VIIDHH.SPQD--E....VEAEGAFVDIRPSS---.-RS 40 ...-......--SKQLPIELPNID-.IIIDHH.NNTD---....--LTAKYMDVRPEV---.-GA 41 ...-......--PGVNNSIPPDIDIsIVIDHH.PAEK---....--VVAEFVDLREDV---.-GA 42 ...N......GNITILDEEDLNKIE.IIIDHHqILQNLRE....KLPPNCFVDIRTDV---.-NA 43 ...-......-IEQLEPIEVPPAKI.VVIDHH.VEKE---....NPIPADVAIIDPTR---.-TS 44 ...I......NQLKVNFDELKEREV.ILIDHH.KKTD---....LADICKYYIIKEDY---.-PS 45 ...A......PPSCRLLLSDSTIRK.IELDHH.LFANAAC....CGDPGYSLIARA-----.-SS 46 ...NeaeylqDKIQEHRLQNKNIQI.QLLDHH.ISGKEVA....ESFHWYFLDINRCA---.--- 47 ...E......NEERLNEYVHAGGKV.KLIDHH.KTALHLN....E-HEWGFVQVEYDDGRL.TSA 48 ...E......DIPAISKAKAYGIEV.IVIDHH.FPGEVVDgkv.EVDDYVDAHVNPYLVGG.DSN 49 ...E......DILALMKAKIYDIEI.VVVDHH.YPGEVQDgrv.EVDEYVDTHVNPYLVGG.DSQ 50 ...E......DIPAYKRLKAYGVKI.VVIDHH.DPRDWISedkaKVDEYVDVHVNPHH---.--- 51 ...E......DVPAIRQFLLFGADV.ITIDHH.FPDE---....EVDSYLLYHVNPYKVGG.DSN 52 ...L......AADMIDKINAGKSMV.LIIDHH.PAKD---....-IDSDYVHVLDPELAGI.SGD 53 ...-......--GQIEEIIKHNFNA.IILDHH.PPVIKDS....F-INENIIQLNPHIFGV.DGS 54 ...-......--AYLEEISRLKGDV.IVADHH.QPSE---....SEAGPHVVHINPHLHGL.DGS 55 ...L......SLIGEHL---KDKSV.VILDHH.PPEP---....VETHEKHILANPVQFGA.NSV 56 ...-......--GYADLISQVDTDV.VILDHH.IPNG--E....IRPKRNLAHVNPHLVGM.DGT 57 ...-......----GVLNMLDGIEF.AITDHH.LPQS---....----HHPMQLNPHDFGY.DGA 58 kmiK......EKLDELNLSDKRDKI.IILDHH.QPEE---....IKIPKTIIHINPLTIAK.SGA 59 ...-......-GQRVHENLKSNSRV.LILDHH.PPVRKMNf...TAPSGDFLEINPIFYGM.DGS 60 ...D......VEGIE-------KET.VFIDHH.IQPK---....-IKNPRVRQINPSLEGKeSPS 61 ...N......AFEAARFCKEKNYTL.IITDHH.CLHH---....DEVPDAYAVINPKQ---.-PD 62 ...M......AHDALKYAKDVKLDV.IVIDHH.ISTE---....-ILPDAVAIVNPNR---.-ID 63 ...A......AVHEAKVAKELGLDV.IITDHH.EPGP---....-ELPDVRAIVHPKQ---.-PG 64 ...S......SHAGVEHARSLGIPV.IVTDHH.LPGD---....-TLPAAEAIINPNL---.-RD 65 ...S......SHAGVDDAHRRGIAV.VVTDHH.LPGE---....-TLPAAEAMINPNL---.-SD 66 ...S......SFDGVAFLKEKGIRV.LVTDHH.LPPE---....-TLPPADAIVNPNL---.-SQ 67 ...S......SIEEINYANSKGIEI.IITDHH.LPGE---....-NFKTENIVINPHL---.-KD 68 ...T......AGKEVSDITRQGIDV.IITDHH.MPTG---....-KIPHCVATLNPKL---.-RD 69 ...T......AGKEVSDINKQGIDV.IITDHH.MPTG---....-KIPHCIATLNPKL---.-RD 70 ...T......AGKEVHAINKQGIDV.IVTDHH.MPTG---....-KLPHCVAMLNPKL---.-DK 71 ...-......--SAVEEIDQSSLET.VVIDHH.NVPP---....-RIPKKALIVNPKV---.-GA 72 ...T......NLDEIVYAQQLGMDV.IVTDHH.TLPD---....-DRPEVVAIINPRY---.-FA 73 ...S......NRAEIAYARHRGIDV.LVIDHH.AAPE---....--TLPDAIIINAKV---.-PG 74 ...S......QFEEHEALNKRGTEI.IVIDHH.ECER---....--VSEHAIVVNNQL---.--S 75 ...A......NTELQEILLEHFEQC.IITDHH.KSFE-VD....WIDENKIAYINLND---.-EK 76 ...-......--LPEGLPRERIKRI.IVYDHH.PIGD---....--VKEFEGKIEKV----.-GA 77 ...P......SLVMEERLVNKIEHI.VVIDHH.RRGE--E....FIRDPLLVYMEPYA---.-SS 78 ...N......QERVLTQKHKLAKET.VRIDHH.PKTE---....--SFADLEWIDPAF---.-SA 79 ...N......QERIDDQRYPSGAKL.MKIDHH.PNED---....--PYGDLLWVDTSA---.-SS 80 ...R......IELRELLDKNLFKAV.LRIDHH.PNED---....-DLNTSFNFVEESY---.-VA 81 ...R......IECRDLLDQNQFKAV.LRIDHH.PNED---....-DLNTTHNFVDASY---.-IA 82 ...-......--FYRVGKEVKVGKR.IRIDHH.VGGE---....--FYGMHDYIDPTA---.-PA 83 ...D......RIGDEFIFYVKNMPT.LVIDHH.MSGE---....--KLECEGYIDPFA---.-PS 84 ...S......RVGAELASQLAPFAR.AFIDHH.ETCG---....--DHCAHSFVVKTA---.-PS 85 ...D......RLGALGDLTDSGREL.LVIDHH.ASND---....--LFGTANFIDPSA---.-DS 86 ...S......QLMPLVQEANIPV-V.VIIDHH.SPQD--E....VEAEGAFVDIRPSS---.-RS 87 ...-......--SKQLPIELPNID-.IIIDHH.NNTD---....--LTAKYMDVRPEV---.-GA 88 ...-......--PGVNNSIPPDIDIsIVIDHH.PAEK---....--VVAEFVDLREDV---.-GA 89 ...N......GNITILDEEDLNKIE.IIIDHHqILQNLRE....KLPPNCFVDIRTDV---.-NA 90 ...-......-IEQLEPIEVPPAKI.VVIDHH.VEKE---....NPIPADVAIIDPTR---.-TS 91 ...I......NQLKVNFDELKEREV.ILIDHH.KKTD---....LADICKYYIIKEDY---.-PS 92 ...A......PPSCRLLLSDSTIRK.IELDHH.LFANAAC....CGDPGYSLIARA-----.-SS 93 ...NeaeylqDKIQEHRLQNKNIQI.QLLDHH.ISGKEVA....ESFHWYFLDINRCA---.--- 94 ...E......NEERLNEYVHAGGKV.KLIDHH.KTALHLN....E-HEWGFVQVEYDDGRL.TSA 95 ...T......AGKEVSDINKQGIDV.IITDHH.MPTG---....-KIPHCIATLNPKL---.-RD 96 ...A......AVHEAKVAKELGLDV.IITDHH.EPGP---....-ELPDVRAIVHPKQ---.-PG 97 ...T......AGKEVHAINKQGIDV.IVTDHH.MPTG---....-KLPHCVAMLNPKL---.-DK 98 ...A......SIAGVARAQALGLDV.IVTDHH.LPAE---....--TVPDCIIVNPNQ---.-KG 99 ...S......SHAGVEHARSLGIPV.IVTDHH.LPGD---....-TLPAAEAIINPNL---.-RD 100 ...S......SLEGVRYAKQKGLQV.VVTDHH.LPGQ---....-ELPEVDAMVNPNL---.-QQ 101 ...S......SHAGVEHARSLGIPV.IVTDHH.LPGD---....-TLPAAEAIINPNL---.-RD 102 ...S......SFDGVAFLKEKGIRV.LVTDHH.LPPE---....-TLPPADAIVNPNL---.-SQ 103 ...S......SHAGVDDAHRRGIAV.VVTDHH.LPGE---....-TLPAAEAMINPNL---.-SD 104 ...T......AGKEVSDITRQGIDV.IITDHH.MPTG---....-KIPHCVATLNPKL---.-RD 105 ...M......AHDALKYAKDVKLDV.IVIDHH.ISTE---....-ILPDAVAIVNPNR---.-ID 106 ...E......DIPAISKAKAYGIEV.IVIDHH.FPGEVVDgkv.EVDDYVDAHVNPYLVGG.DSN 107 ...A......SIAGVARAQALGLDV.IVTDHH.LPAE---....--TVPDCIIVNPNQ---.-KG 108 ...R......IECRDLLDQNQFKAV.LRIDHH.PNED---....-DLNTTHNFVDASY---.-IA 109 ...T......ALDSVALAKKFGMKV.IVTDHH.EVNG---....-DLPPADAIVNPKV---.-PG 110 ...D......RIGDEFIFYVKNMPT.LVIDHH.MSGE---....--KLECEGYIDPFA---.-PS 111 ...E......DILALMKAKIYDIEI.VVVDHH.YPGEVQDgrv.EVDEYVDTHVNPYLVGG.DSQ 112 ...T......AGREVRSINKQGIDV.IVTDHH.TPTG---....-KLPHCIATLNPKL---.-DK 113 ...E......DVPAIRQFLLFGADV.ITIDHH.FPDE---....EVDSYLLYHVNPYKVGG.DSN 114 ...A......CHAGVAAAKARGWTV.LVTDHH.LPGE---....-VLPPADAIVDPNL---.-VQ 115 ...R......IELRELLDKNLFKAV.LRIDHH.PNED---....-DLNTSFNFVEESY---.-VA 116 kmiK......EKLDELNLSDKRDKI.IILDHH.QPEE---....IKIPKTIIHINPLTIAK.SGA 117 ...A......SIAGVARAQALGLDV.IVTDHH.LPAD---....--TVPDCIIVNPNQ---.-KG 118 ...A......CHAGVAAAKARGWQV.LVTDHH.LPGE---....-ILPPADVIVNPNL---.-PG 119 ...S......SIEEINYANSKGIEI.IITDHH.LPGE---....-NFKTENIVINPHL---.-KD 120 ...-......--SAVEEIDQSSLET.VVIDHH.NVPP---....-RIPKKALIVNPKV---.-GA 121 ...S......SIEEINYANSKGIEI.IITDHH.LPGE---....-NFKTENIVINPHL---.-KD 122 ...A......ALEAAKLCKEKNIDL.IITDHH.MPQD---....-ILPDAFAIINPKQ---.-KD 123 ...N......QERIDDQRYPSGAKL.MKIDHH.PNED---....--PYGDLLWVDTSA---.-SS 124 ...D......RLGALGDLTDSGREL.LVIDHH.ASND---....--LFGTANFIDPSA---.-DS 125 ...S......SIEEINYANSKGIEI.IITDHH.LPGE---....-NFKTENIVINPHL---.-KD 126 ...S......QLMPLVQEANIPV-V.VIIDHH.SPQD--E....VEAEGAFVDIRPSS---.-RS 127 ...N......QERVLTQKHKLAKET.VRIDHH.PRTE---....--KFADMEWIDSSF---.-SA 128 ...N......QERVLTQKHKLAKET.VRIDHH.PKTE---....--SFADLEWIDPAF---.-SA 129 ...E......DIPAYKRLKAYGVKI.VVIDHH.DPREWISedkaKVDEYVDVHVNPHH---.--- 130 ...E......DIPAYKRLKAYGVKI.VVIDHH.DPRDWISedkaKVDEYVDVHVNPHH---.--- 131 ...N......GNITILDEEDLNKIE.IIIDHHqILQNLRE....KLPPNCFVDIRTDV---.-NA 132 ...A......PPSCRLLLSDSTIRK.IELDHH.LFANAAC....CGDPGYSLIARA-----.-SS 133 ...S......QFEEHEALNKRGTEI.IVIDHH.ECER---....--VSEHAIVVNNQL---.--S 134 ...S......NLDEVKSLLATGTEV.VVTDHH.APGE---....--NFPECLVVHPHL---.TPD 135 ...L......SIIKEHL---KDRTV.IILDHH.PPEN---....VELPEKHILVNPVQFGA.NSV 136 ...L......SLIGEHL---KDKSV.VILDHH.PPEP---....VETHEKHILANPVQFGA.NSV 137 ...P......SLVMEERLVNKIEHI.VVIDHH.RRGE--E....FIRDPLLVYMEPYA---.-SS 138 ...R......VGKEV-----KVGKR.IRIDHH.VGGE---....--FYGMHDYIDPTA---.-PA 139 ...N......GNITILDDDDLKRVE.IIVDHHqILQNLRE....KLSPNCFVDIRTDV---.-NA 140 ...S......RVGAELASQLAPFAR.AFIDHH.ETCG---....--DHCAHSFVVKTA---.-PS 141 ...-......--AYLEEISRLKGDV.IVADHH.QPSE---....SEAGPHVVHINPHLHGL.DGS 142 ...-......-GQRVHENLKSNSRV.LILDHH.PPVRKMNf...TAPSGDFLEINPIFYGM.DGS 143 ...S......NIELQKILLERFEQC.IITDHH.KSFE-VD....WIDKNKIAYINLND---.-EK 144 ...T......NLDEIVYAQQLGMDV.IVTDHH.TLPD---....-DRPEVVAIINPRY---.-FA 145 ...-......--GYADLISQVDTDV.VILDHH.IPNG--E....IRPKRNLAHVNPHLVGM.DGT 146 ...L......AADMIDKINAGKSMV.LIIDHH.PAKD---....-IDSDYVHVLDPELAGI.SGD 147 ...Q......SIADIREVEV----V.EVVDHH.RVAN--F....ETANPLYMRLEPV----.-GS 148 ...I......NQLKVNFDELKEREV.ILIDHH.KKTD---....LADICKYYIIKEDY---.-PS 149 ...A......NTELQEILLEHFEQC.IITDHH.KSFE-VD....WIDENKIAYINLND---.-EK 150 ...A......NTELQEILLEHFEQC.IITDHH.KSFE-VD....WIDENKIAYINLND---.-EK 151 ...N......AFEAARFCKEKNYTL.IITDHH.CLHH---....DEVPDAYAVINPKQ---.-PD 152 ...S......NRAEIAYARHRGIDV.LVIDHH.AAPE---....--TLPDAIIINAKV---.-PG 153 ...R......IGKFQDLLDK--VPS.VVIDHH.STNT---....--NFGNWNWVDPSF---.-AA 154 ...P......VRVAGADLTQFDGPV.VNVDHH.GTNL---....--RRADAGVVDPSK---.-PA 155 ...Q......SIKDIEEVQV----L.EVIDHH.RIAN--F....ETAEPLYYRAEPV----.-GC 156 ...Q......SVADIAEVEV----Y.GVVDHH.RVAN--F....ETANPLYMRLEPV----.-GS 157 ...-......--PGVNNSIPPDIDIsIVIDHH.PAEK---....--VVAEFVDLREDV---.-GA 158 ...K......QLPIELPNID-----.IIIDHH.NNTD---....--LTAKYMDVRPEV---.-GA 159 ...-......-IEQLEPIEVPPAKI.VVIDHH.VEKE---....NPIPADVAIIDPTR---.-TS 160 ...Q......APDDLNQAEI----L.GIVDHH.RLGD--V....MTVNPLEAWIWPV----.-GC 161 ...-......----GVLNMLDGIEF.AITDHH.LPQS---....----HHPMQLNPHDFGY.DGA 162 ...N......QERVLSQKHRLAKKT.ILVDHH.VKTI---....--TYTDLEYINDQS---.-IA 163 ...D......VEGIEKE-------T.VFIDHH.IQPK---....-IKNPRVRQINPSLEGKeSPS 164 ...D......RIPESIRKKAQGAKI.TVYDHH.VDES---....----PYDGIVSKV----.-GA 165 ...Q......IAGAESLFRAARL-K.VVIDHH.ERGS---....IHEEADVALVDPGA---.-GS 166 ...-......--GQIEEIIKHNFNA.IILDHH.PPVI-KD....SFINENIIQLNPHIFGV.DGS 167 ...Q......TVDGIDKAEV----V.AIVDHH.KIGD---....VTTPQPILFVNLPV---.-GC 168 ...N......AFEAAQFCKEKNYTL.IITDHH.CLHH---....DEIPDAYAVINPKQ---.-PD 169 ...E......QL--EPIKIPPNAKL.IVIDHH.VEKE---....NPIPADISVIDPKR---.-TS 170 ...NeaeylqDKIQEHRLQNKNIQI.QLLDHH.ISGKEVA....ESFHWYFLDINRCA---.--- 171 ...E......NEERLNEYVHAGGKV.KLIDHH.KTALHLN....E-HEWGFVQVEYDDGRL.TSA 172 ...NeaeylqDKIQEHRLQNKDIQI.QLLDHH.ISGKEVA....ESFHWYFLDTNRCA---.--- 173 ...-......----PREAEKLRVPT.VFIDHH.SQPR---....-IKNPLVKHVNPVLEGRyYPS 174 ...R......IELRELLDKNLFKAV.LRIDHH.PNED---....-DLNTSFNFVEESY---.-VA 175 ...Q......SLPALGELDV----T.RVVDHH.KLGD--L....TTINPPYLRFEPV----.-GC 176 ...Q......SFDDLEEGKL----I.AIIDHH.KVGL---....TTTEPILYYAKPV----.-GS 177 ...R......IECRDLLDQNQFKAV.LRIDHH.PNED---....-DLNTTHNFVDASY---.-IA 178 ...E......GLPRERI-----KRI.IVYDHH.PIGD---....--VKEFEGKIEKV----.-GA 0 150 160 170 180 | | | | | 1 LTAGVLGTEIA--------RMINP..DV.......E........DEIKHIPGIAVVGD---hak. 2 ITAGSLSVEIA--------KMINP..EI.......A........ERILHLPGIAAVGD---han. 3 VKRGYYELTAGMLATEVARYVNPA..VE.......D........KIKHLPAIAG-------tgdr 4 YTSGVLCVEIA-----------RM..IS.......D........LDMKHLAAISVVGD---rae. 5 -----VFVSASSLNYIFFRAVAGE..E-.......A........KKYAYIAVLGSVGDY--hd.. 6 -----REITASGVCYLV----ARE..FG.......Y........YDLSVLAIVGIIGDMQ-y... 7 -----RDLSASGTAYL-----ATR..LL.......N........RKTAPLALVGALGDMQ-y... 8 -----RDLSGSGVSYFFAREL--N..EM.......N........KDLAYIAIVGAVGDMQ-e... 9 -----FELSASGVCYFFA---NEL..GR.......N........RELASVALIGALGDKQR.... 10 -----FELSGATTTYLVSKYLRNG..RTlfdyendN........SDLLPISIVGAVGDLQ-d... 11 ------EICGAGVSYLFAKAINND..WI.......D........--LAKYAVLGAVGDIQN.... 12 -----THVSGGGLTYLL----ARE..FG.......Y........RDLSWMGLLAAVGDMQN.... 13 ASFVVSEYFDV-------------..--.......-........--WNTWTALGAVGDVG-e... 14 CDFIQKEVCGALVAFYLCYGIHQL..LG.......Kekshs...SELLCLAGVATIADMMP.... 15 ETSEYKYLAAVGVTFLFATAILSN..LK.......Krny13pnlMKYLDLVALGTVCDMM-k... 16 CTYPFKELAGVGVAFKLAHALLGE..LP.......D........-ELLDLAAIGTIADLV-p... 17 CNFPSKSLAGVGVAFYLMLALRTF..LR.......Dqgw14pnlAELLDLVALGTVADVV-p... 18 CAFPSKALAGVGVAFYLMMALRAN..LR.......Ecgw14pnlAELLDLVALGTVADVV-p... 19 CGFPSKSLAGVGVAFYLMLAVRAK..FR.......Elgi12pnfTDLLDLVALGTIADVV-p... 20 DKYPFKEIAGCCVSFKACLA----..--.......-........-----------------ls16 21 HTYPNRELTGVGVAFKLARGVLNA..LI.......Srnl11gslKKLLDLVTLGTITDVG-v... 22 RAYPNKELTGVGVAFKLARGVLNA..LR.......Kenp9kvdtKHLLDLVTLGTVTDVG-t... 23 NPYPNKELTGVGVAFKLVCATYEE..LI.......Qqda11idlLRFLDLVSLGTIADVGR.... 24 KREGLKALSSSALSFYLGSALIRE..FNlded...P........RNFLDLVALGLLADYMP.... 25 DGHPLFNLSGVAVAFKLVEALYNQ..YP.......Tvpqqpl..EDLLDLVAIGLIADL--vt.. 26 AGYPHEFLSGCATAWKVVTA----..--.......-........-----------------lr16 27 PNYSNKTLTGAGMAYKFCQAIDEK..LN.......Knea.....EQFLDLVSIGNIAD---sad. 28 DANYYSGAFTSALVFSQIFQTQTT..PL.......E........EELIAITLLS-------drid 29 ATTLVVEEIKE----------KGI..DI.......N........PRDATLLAFGIYEDTGN.... 30 TAELVTELLEY--------QPKRL..KI.......N........MIEATALLAGIIVDT--ks.. 31 AAEMVGYLILQ----------MGY..EL.......N........AEMAAYIYAGIITDTQR.... 32 VSEMIYELYLEGKE-------HGW..KL.......N........TKAAELIYAGIVGDTGR.... 33 CCEQIVEMATV----------AKW..TI.......P........PVAATLLYIGIYTDSN-r... 34 AAEQVVDLAVQ----------AKW..KL.......S........PPAATALYLGIYTDSN-r... 35 TAALVYEIIKNW---------DET..AI.......D........KDIATCIYTGLATDTG-f... 36 TTFLIEKLIRE----------FGH..DL.......T........KEEAWYILVGFCTDTG-f... 37 TTTLVQTLIET----------MAG..SL.......E........AAEARALFLGLATDTG-f... 38 TTTMVAEILDA----------WGK..PI.......D........PRVAHCIYAGLATDTG-s... 39 TATILTEYLQGGMLDFN----SSN..PT.......H........VKCATALMHGLRSDTI-n... 40 TASILTQYLME----------LDI..EP.......S........RNLATALFYGIQSDT--dy.. 41 TATILTEYIKE----------LKI..TP.......S........KILATALFFGIKS----etde 42 TSSIMAEYLKA----------LEI..PI.......T........ETLATALFYGMYIDT--kk.. 43 TAEIVWELFKK-----------FN..YS.......D........ENSAKALLAGIISDTS-n... 44 TSEIIAEIFKE----------LNI..FP.......P........KNVRIALLCGIVYDT--kh.. 45 TCEIIAYLCYKLARNHAQRTALGIrnLY.......S........RNVVLSILTGMIGD---akt. 46 -TKIVYEFLKKHYA----------..--.......-........-----------------ile1 47 TSLLYGYLIENG------------..--.......-........-----------------fmk1 48 LTAGVLGTEIA--------RMINP..DV.......E........DEIKHIPGIAVVGD---hak. 49 ITAGSLSVEIA--------KMINP..EI.......A........ERILHLPGIAAVGD---han. 50 VKRGYYELTAGMLATEVARYVNPA..VE.......D........KIKHLPAIAG-------tgdr 51 YTSGVLCVEIA-----------RM..IS.......D........LDMKHLAAISVVGD---rae. 52 -----VFVSASSLNYIFFRAVAGE..E-.......A........KKYAYIAVLGSVGDY--hd.. 53 -----REITASGVCYLV----ARE..FG.......Y........YDLSVLAIVGIIGDMQ-y... 54 -----RDLSASGTAYL-----ATR..LL.......N........RKTAPLALVGALGDMQ-y... 55 -----RDLSGSGVSYFFAREL--N..EM.......N........KDLAYIAIVGAVGDMQ-e... 56 -----FELSASGVCYFFA---NEL..GR.......N........RELASVALIGALGDKQR.... 57 -----FELSGATTTYLVSKYLRNG..RTlfdyendN........SDLLPISIVGAVGDLQ-d... 58 ------EICGAGVSYLFAKAINND..WI.......D........--LAKYAVLGAVGDIQN.... 59 -----THVSGGGLTYLL----ARE..FG.......Y........RDLSWMGLLAAVGDMQN.... 60 ASFVVSEYFDV-------------..--.......-........--WNTWTALGAVGDVG-e... 61 CDFIQKEVCGALVAFYLCYGIHQL..LG.......Kekshs...SELLCLAGVATIADMMP.... 62 ETSEYKYLAAVGVTFLFATAILSN..LK.......Krny13pnlMKYLDLVALGTVCDMM-k... 63 CTYPFKELAGVGVAFKLAHALLGE..LP.......D........-ELLDLAAIGTIADLV-p... 64 CNFPSKSLAGVGVAFYLMLALRTF..LR.......Dqgw14pnlAELLDLVALGTVADVV-p... 65 CAFPSKALAGVGVAFYLMMALRAN..LR.......Ecgw14pnlAELLDLVALGTVADVV-p... 66 CGFPSKSLAGVGVAFYLMLAVRAK..FR.......Elgi12pnfTDLLDLVALGTIADVV-p... 67 DKYPFKEIAGCCVSFKACLA----..--.......-........-----------------ls16 68 HTYPNRELTGVGVAFKLARGVLNA..LI.......Srnl11gslKKLLDLVTLGTITDVG-v... 69 RAYPNKELTGVGVAFKLARGVLNA..LR.......Kenp9kvdtKHLLDLVTLGTVTDVG-t... 70 NPYPNKELTGVGVAFKLVCATYEE..LI.......Qqda11idlLRFLDLVSLGTIADVGR.... 71 KREGLKALSSSALSFYLGSALIRE..FNlded...P........RNFLDLVALGLLADYMP.... 72 DGHPLFNLSGVAVAFKLVEALYNQ..YP.......Tvpqqpl..EDLLDLVAIGLIADL--vt.. 73 AGYPHEFLSGCATAWKVVTA----..--.......-........-----------------lr16 74 PNYSNKTLTGAGMAYKFCQAIDEK..LN.......Knea.....EQFLDLVSIGNIAD---sad. 75 DANYYSGAFTSALVFSQIFQTQTT..PL.......E........EELIAITLLS-------drid 76 ATTLVVEEIKE----------KGI..DI.......N........PRDATLLAFGIYEDTGN.... 77 TAELVTELLEY--------QPKRL..KI.......N........MIEATALLAGIIVDT--ks.. 78 AAEMVGYLILQ----------MGY..EL.......N........AEMAAYIYAGIITDTQR.... 79 VSEMIYELYLEGKE-------HGW..KL.......N........TKAAELIYAGIVGDTGR.... 80 CCEQIVEMATV----------AKW..TI.......P........PVAATLLYIGIYTDSN-r... 81 AAEQVVDLAVQ----------AKW..KL.......S........PPAATALYLGIYTDSN-r... 82 TAALVYEIIKNW---------DET..AI.......D........KDIATCIYTGLATDTG-f... 83 TTFLIEKLIRE----------FGH..DL.......T........KEEAWYILVGFCTDTG-f... 84 TTTLVQTLIET----------MAG..SL.......E........AAEARALFLGLATDTG-f... 85 TTTMVAEILDA----------WGK..PI.......D........PRVAHCIYAGLATDTG-s... 86 TATILTEYLQGGMLDFN----SSN..PT.......H........VKCATALMHGLRSDTI-n... 87 TASILTQYLME----------LDI..EP.......S........RNLATALFYGIQSDT--dy.. 88 TATILTEYIKE----------LKI..TP.......S........KILATALFFGIKS----etde 89 TSSIMAEYLKA----------LEI..PI.......T........ETLATALFYGMYIDT--kk.. 90 TAEIVWELFKK-----------FN..YS.......D........ENSAKALLAGIISDTS-n... 91 TSEIIAEIFKE----------LNI..FP.......P........KNVRIALLCGIVYDT--kh.. 92 TCEIIAYLCYKLARNHAQRTALGIrnLY.......S........RNVVLSILTGMIGD---akt. 93 -TKIVYEFLKKHYA----------..--.......-........-----------------ile1 94 TSLLYGYLIENG------------..--.......-........-----------------fmk1 95 RAYPNKELTGVGVAFKLARGVLNA..LR.......Kenp9kvdtKHLLDLVTLGTVTDVG-.... 96 CTYPFKELAGVGVAFKLAHALLGE..LP.......D........-ELLDLAAIGTIADLV-.... 97 NPYPNKELTGVGVAFKLVCATYEE..LI.......Qqda11idlLRFLDLVSLGTIADVGR.... 98 CGFPSKSLAGVGVIFYVLMALRAE..LR.......Rrny13pnlGELLDLVALGTVADVVP.... 99 CNFPSKSLAGVGVAFYLMLALRTF..LR.......Dqgw14pnlAELLDLVALGTVADVVP.... 100 CAFPSKALAGVGVAFYLMMALCVH..MR.......Qqgw14pklMELIDLVALGTVADVVP.... 101 CNFPSKSLAGVGVAFYLMLALRTF..LR.......Dqgw14pnlAELLDLVALGTVADVVP.... 102 CGFPSKSLAGVGVAFYLMLAVRAK..FR.......Elgi12pnfTDLLDLVALGTIADVVP.... 103 CAFPSKALAGVGVAFYLMMALRAN..LR.......Ecgw14pnlAELLDLVALGTVADVVP.... 104 HTYPNRELTGVGVAFKLARGVLNA..LI.......Srnl11gslKKLLDLVTLGTITDV--.... 105 ETSEYKYLAAVGVTFLFATAILSN..LK.......Krny13pnlMKYLDLVALGTVCDMM-.... 106 LTAGVLGTEIA--------RMINP..DV.......E........DEIKHIPGIAVVGD---.... 107 CGFPSKSLAGVGVIFYVLMALRAE..LR.......Rrny13pnlGDLLDLVALGTVADV--.... 108 AAEQVVDLAVQ----------AKW..KL.......S........PPAATALYLGIYTDSN-.... 109 ENYPFRDLAGVGVTYKLVQALSEA..TN.......Yphp.....ERFLELVALGTVADMV-.... 110 TTFLIEKLIRE----------FGH..DL.......T........KEEAWYILVGFCTDTG-.... 111 ITAGSLSVEIA--------KMINP..EI.......A........ERILHLPGIAAVGD---.... 112 NSYPNKELTGVGVAFKLVCATYEE..LI.......Kqda11idlLHFLDLVSLGTIADVGR.... 113 YTSGVLCVEIA-----------RM..IS.......D........LDMKHLAAISVVGD---.... 114 DSFPSKTLAGVGVIFYVLLALRGV..LR.......Arga12pdlSVLLDLVAVGTVADLV-.... 115 CCEQIVEMATV----------AKW..TI.......P........PVAATLLYIGIYTDSN-.... 116 ------EICGAGVSYLFAKAINND..WI.......D........--LAKYAVLGAVGDIQN.... 117 CGFPSKSLAGVGVIFYVLTALRAE..LR.......Rrny13pnlGGLLDLVALGTVADVVP.... 118 DLFPSKTLAGVGVIFYVLLALRAR..LY.......Pvah25pdlTSLLDLVAVGTVADLV-.... 119 DKYPFKEIAGCCVSFKACLAL---..--.......-........-----------------.... 120 KREGLKALSSSALSFYLGSALIRE..FNlded...P........RNFLDLVALGLLADYMP.... 121 DKYPFKEIAGCCVSFKACLAL---..--.......-........-----------------.... 122 CDFPEIEICGAQVAWYLIAALKEVc.-K.......Lkydm....CKFLELLAIAIVADMM-.... 123 VSEMIYELYLEGKE-------HGW..KL.......N........TKAAELIYAGIVGDTGR.... 124 TTTMVAEILDA----------WGK..PI.......D........PRVAHCIYAGLATDTG-.... 125 DKYPFKEIAGCCVSFKACLAL---..--.......-........-----------------.... 126 TATILTEYLQGGMLDFN----SSN..PT.......H........VKCATALMHGLRSDTI-.... 127 TAEMIGYLILQ----------MGY..KL.......N........DEIASYLYAGIITDTQR.... 128 AAEMVGYLILQ----------MGY..EL.......N........AEMAAYIYAGIITDTQR.... 129 VKRGYYELTAGMLATEVARFI-NP..EV.......E........DKIKHLPAIAGTGD---.... 130 VKRGYYELTAGMLATEVARYV-NP..AV.......E........DKIKHLPAIAGTGD---.... 131 TSSIMAEYLKA----------LEI..PI.......T........ETLATALFYGMYIDT--.... 132 TCEIIAYLCYKLARNHAQRTALGIrnLY.......S........RNVVLSILTGMIGD---.... 133 PNYSNKTLTGAGMAYKFCQAIDEK..LN.......Knea.....EQFLDLVSIGNIADS--.... 134 YDPDRHNLTGAGVAYHLLWAVYEE..LG.......Rpep.....RALLPLATLGTVADV--.... 135 -----RDLSGSGVCYFFAREL--N..ER.......N........KDLAYIAIVGAVGDMQ-.... 136 -----RDLSGSGVSYFFAREL--N..EM.......N........KDLAYIAIVGAVGDMQ-.... 137 TAELVTELLEY--------QPKRL..KI.......N........MIEATALLAGIIVDT--.... 138 TAALVYEIIKNW---------DET..AI.......D........KDIATCIYTGLATDTG-.... 139 TSSIMVEYLKA----------LEI..PI.......T........DTLATALFYGMYIDT--.... 140 TTTLVQTLIET----------MAG..SL.......E........AAEARALFLGLATDTG-.... 141 -----RDLSASGTAYL-----ATR..LL.......N........RKTAPLALVGALGDMQ-.... 142 -----THVSGGGLTYLL----ARE..FG.......Y........RDLSWMGLLAAVGDMQN.... 143 DAN---YYSGAFTSALVFSQIFQI..QT.......T........PLEEELIAITLLSD---.... 144 DGHPLFNLSGVAVAFKLVEALYNQ..YP.......Tvpqqpl..EDLLDLVAIGLIADL--.... 145 -----FELSASGVCYFFA---NEL..GR.......N........RELASVALIGALGDKQR.... 146 -----VFVSASSLNYIFFRAVAGE..E-.......A........KKYAYIAVLGSVGDY--.... 147 ASSIVYRLYKE----------NGV..AI.......P........KEIAGVMLSGLISDT--.... 148 TSEIIAEIFKE----------LNI..FP.......P........KNVRIALLCGIVYDT--.... 149 DAN---YYSGAFTSALVFSQIFQT..QT.......T........PLEEELIAITLLSD---.... 150 DAN---YYSGAFTSALVFSQIFQT..QT.......T........PLEEELIAITLLSD---.... 151 CDFIQKEVCGALVAFYLCYGIHQL..LG.......Kekshs...SELLCLAGVATIADMMP.... 152 AGYPHEFLSGCATAWKVVTA----..--.......-........-----------------.... 153 TAQMIFRINKA----------LGV..EY.......D........SNLATLNYLGIATDTG-.... 154 AAMMVADVIDA----------LGA..PW.......S........EAVATPLMLGLNTDTGN.... 155 TATILNKMYKE----------NNV..KI.......E........KEIAGLMLSAIISD---.... 156 ASSIVYRMFKE----------HSV..AV.......S........KEIAGLMLSGLISDT--.... 157 TATILTEYIKE----------LKI..TP.......S........KILATALFFGIKSE---.... 158 TASILTQYLME----------LDI..EP.......S........RNLATALFYGIQSDT--.... 159 TAEIVWELFKK-----------FN..YS.......D........ENSAKALLAGIISDTS-.... 160 TSTILFNLFKM----------ENA..EI.......T........RPLALLMISAILSDTV-.... 161 -----FELSGATTTYLVSKYLRNG..RTlfdy...-endn....SDLLPISIVGAVGDLQ-.... 162 ACEMIAYSLMH----------TNL..NF.......D........LKTLNYLLLGITTDSN-.... 163 ASFVVSEYFDV-------------..--.......-........--WNTWTALGAVGDVG-.... 164 TITILVELIRE----------KNI..PL.......D........PTEATLFMIALYDDTGN.... 165 SSELAVKTAVE----------AGT..PL.......R........PSVATAALGGIVYDTGR.... 166 -----REITASGVCYLV----ARE..FG.......Y........YDLSVLAIVGIIGDMQ-.... 167 TATVIKLLFDK----------TGV..EI.......P........KDIAGILLSSILSDT--.... 168 CDFIQKEVCGALVAFYLCYGIHQL..LG.......Kekshs...SELLCLAGVATIADMMP.... 169 TAEIVWELFKK----------LGY..K-.......D........EDSAKVLLAAIISDT--.... 170 -TKIVYEFLKKHYAI------LEP..KN.......T........TWL--------------.... 171 TSLLYGYLIEN-------------..--.......-........-----------------.... 172 -TKIVYEFLKKYYAIL--------..--.......-........-----------------.... 173 ASFVVSEYLNY-------------..--.......-........--WNEWSALGVVGDI--.... 174 CCEQIVEMATV----------AKW..TI.......P........PVAATLLYIGIYTDSN-.... 175 TGTILLKLHRE----------AGL..SV.......E........PQDAKLMLSAILSDT--.... 176 TATVIAELYFKDAIDLI--GGKKK..EL.......K........PDLAGLLLSAIISDT--.... 177 AAEQVVDLAVQ----------AKW..KL.......S........PPAATALYLGIYTDSN-.... 178 ATTLVVEEIKE----------KGI..DI.......N........PRDATLLAFGIYEDTGN.... 1 ..... 2 ..... 3 sk... 4 ..... 5 ..... 6 ..... 7 ..... 8 ..... 9 ..... 10 ..... 11 ..... 12 ..... 13 ..... 14 ..... 15 ..... 16 ..... 17 ..... 18 ..... 19 ..... 20 5nmp. 21 ..... 22 ..... 23 ..... 24 ..... 25 ..... 26 7lmv. 27 ..... 28 ..... 29 ..... 30 ..... 31 ..... 32 ..... 33 ..... 34 ..... 35 ..... 36 ..... 37 ..... 38 ..... 39 ..... 40 ..... 41 ..... 42 ..... 43 ..... 44 ..... 45 ..... 46 9vns. 47 7vrq. 48 ..... 49 ..... 50 sk... 51 ..... 52 ..... 53 ..... 54 ..... 55 ..... 56 ..... 57 ..... 58 ..... 59 ..... 60 ..... 61 ..... 62 ..... 63 ..... 64 ..... 65 ..... 66 ..... 67 5nmp. 68 ..... 69 ..... 70 ..... 71 ..... 72 ..... 73 7lmv. 74 ..... 75 ..... 76 ..... 77 ..... 78 ..... 79 ..... 80 ..... 81 ..... 82 ..... 83 ..... 84 ..... 85 ..... 86 ..... 87 ..... 88 ..... 89 ..... 90 ..... 91 ..... 92 ..... 93 9vns. 94 7vrq. 95 ..... 96 ..... 97 ..... 98 ..... 99 ..... 100 ..... 101 ..... 102 ..... 103 ..... 104 ..... 105 ..... 106 ..... 107 ..... 108 ..... 109 ..... 110 ..... 111 ..... 112 ..... 113 ..... 114 ..... 115 ..... 116 ..... 117 ..... 118 ..... 119 ..... 120 ..... 121 ..... 122 ..... 123 ..... 124 ..... 125 ..... 126 ..... 127 ..... 128 ..... 129 ..... 130 ..... 131 ..... 132 ..... 133 ..... 134 ..... 135 ..... 136 ..... 137 ..... 138 ..... 139 ..... 140 ..... 141 ..... 142 ..... 143 ..... 144 ..... 145 ..... 146 ..... 147 ..... 148 ..... 149 ..... 150 ..... 151 ..... 152 ..... 153 ..... 154 ..... 155 ..... 156 ..... 157 ..... 158 ..... 159 ..... 160 ..... 161 ..... 162 ..... 163 ..... 164 ..... 165 ..... 166 ..... 167 ..... 168 ..... 169 ..... 170 ..... 171 ..... 172 ..... 173 ..... 174 ..... 175 ..... 176 ..... 177 ..... 178 .....