; SAM: prettyalign v3.2 (July 31, 2000) compiled 08/11/00_16:27:51 ; (c) 1992-2000 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequences correspond to the following labels: ; 1 Q58598/358-537 ; 2 O26857/343-522 ; 3 O58078/350-531 ; 4 O28932/329-499 ; 5 O30161/24-173 ; 6 Y831_METJA/19-168 ; 7 O27473/31-174 ; 8 O57804/23-171 ; 9 O29559/20-162 ; 10 O29523/14-162 ; 11 Y977_METJA/15-169 ; 12 O26266/1-146 ; 13 O29950/1-131 ; 14 O25115/42-203 ; 15 Q9ZD22/80-250 ; 16 O32044/76-232 ; 17 RECJ_ECOLI/67-239 ; 18 RECJ_ERWCH/66-238 ; 19 RECJ_HAEIN/63-233 ; 20 O51269/73-370 ; 21 Q9Z7Z0/82-250 ; 22 P94659/11-177 ; 23 O84453/81-249 ; 24 O67909/73-229 ; 25 P73518/80-246 ; 26 O83702/72-370 ; 27 O31903/58-212 ; 28 O25177/21-204 ; 29 O66728/1-143 ; 30 YYBT_BACSU/333-502 ; 31 Y371_MYCPN/15-167 ; 32 O34600/8-159 ; 33 MGPA_MYCGE/55-209 ; 34 MGPA_MYCPN/17-173 ; 35 O67552/12-160 ; 36 O51564/17-170 ; 37 O83450/37-192 ; 38 P71615/29-184 ; 39 P72962/61-231 ; 40 YG33_METJA/160-312 ; 41 O28250/152-306 ; 42 O58017/157-321 ; 43 O73979/14-165 ; 44 Y988_METJA/5-161 ; 45 O83781/33-211 ; 46 O25683/3-150 ; 47 O31824/1-143 ; 48 Q58598/358-537 ; 49 O26857/343-522 ; 50 O58078/350-531 ; 51 O28932/329-499 ; 52 O30161/24-173 ; 53 Y831_METJA/19-168 ; 54 O27473/31-174 ; 55 O57804/23-171 ; 56 O29559/20-162 ; 57 O29523/14-162 ; 58 Y977_METJA/15-169 ; 59 O26266/1-146 ; 60 O29950/1-131 ; 61 O25115/42-203 ; 62 Q9ZD22/80-250 ; 63 O32044/76-232 ; 64 RECJ_ECOLI/67-239 ; 65 RECJ_ERWCH/66-238 ; 66 RECJ_HAEIN/63-233 ; 67 O51269/73-370 ; 68 Q9Z7Z0/82-250 ; 69 P94659/11-177 ; 70 O84453/81-249 ; 71 O67909/73-229 ; 72 P73518/80-246 ; 73 O83702/72-370 ; 74 O31903/58-212 ; 75 O25177/21-204 ; 76 O66728/1-143 ; 77 YYBT_BACSU/333-502 ; 78 Y371_MYCPN/15-167 ; 79 O34600/8-159 ; 80 MGPA_MYCGE/55-209 ; 81 MGPA_MYCPN/17-173 ; 82 O67552/12-160 ; 83 O51564/17-170 ; 84 O83450/37-192 ; 85 P71615/29-184 ; 86 P72962/61-231 ; 87 YG33_METJA/160-312 ; 88 O28250/152-306 ; 89 O58017/157-321 ; 90 O73979/14-165 ; 91 Y988_METJA/5-161 ; 92 O83781/33-211 ; 93 O25683/3-150 ; 94 O31824/1-143 10 20 30 40 50 | | | | | 1 .......AVLDGRPIIIRHHA--DTDGYCGGIALEKAILPIidkfaiD.VDAIWHFFKR--RPSK 2 .......AVYDGRSILVRHHA--DADGICAGVAIEKAVLPLlrdlnpS.TDAEWHYFKR--APSK 3 .......AIFEGRPIILRHHA--DTDGYTAGVALETAIVPLieevapD.PDARWHLFKR--RPSR 4 .......AIYESRPVIIRHHW--DADGTCGGVALEKALTDLvervhsD.SEAKYYLVKR--RVSR 5 rs.....--YAGGGVTVVHHN--DADGLCSGALLKKLCEYC......G.FEAELICIEK------ 6 i......-LNHYGYIRVITHH--DTDGLSSGGILAKMLMRT......N.KLFHLTVVEHLSKEVI 7 .......HLERGNIIRIISHN--DADGLSAAGVVARAISSM......N.GQFHISILSRLKKEF- 8 .......HIELGHTIRIISHR--DADGITSAAILAKALARE......G.AKFHISIVKQ------ 9 l......-VARHDFIRIYTHH--DADGISAGAIIAKALLKA......G.KAFHITFLKGLNEPFE 10 r......-ILKNEEVLVVTHI--DADGITAGTIAHTSLLRA......G.VESGIRFVKQLDESEI 11 qn.....--NKNNKILIVTHI--DTDGLTSRAILQKLAERL......N.LDADFMFLKQ------ 12 m......-VESSETVTVYSHT--DCDGITAATVLSKVLERL......D.MDHEVRIININEVPEV 13 mismn..--------LIIHHW--DTDGITSAALLIKALELD......E.FRNMSPPIGE------ 14 a......-MRTNTEILVVGDY--DADGVISSAIMAKFFESL......NyKHVRIAIPNRFMDGYG 15 .......AIVNSQQICIFADY--DVDGATSAALLKHFLRDL......N.IICDIYVPDRIYEGYG 16 .......AISQQEKIMIYGDY--DADGVTSTSVMLHTLQKL......S.AQVDFYIPDRFKEGYG 17 a......-FREGTRIIVVGDF--DADGATSTALSVLAMRSL......GcSNIDYLVPNRFEDGYG 18 .......ALADNRRIVIVGDF--DADRATSTALTVLALRSM......AaREVQYLVPNRFEDGYG 19 ay.....--QPQQKIVIVGDF--DADGATSTALSVLALRQL......GfSDVDYLVPNRFEQGYG 20 .......AIKNNENILIFGDK--DADGITATIIMYETLKDF......G.LNVSYKIPSN-GEFYG 21 a......-RDRKEHVMIYGDS--DVDGMTGVALLVEFLRDI......D.VHVSYFFLGAILKQHG 22 .......AKERNEHVMVYGDS--DVDGMTGVALLVEFLRSI......D.MKVSYCFLGALLKHYG 23 a......-KANNEHVMIYGDG--DVDGITGVTLIVEFLQIL......G.VKTSYCCSGTLFKQHG 24 .......AVLKKKRIIIYGDY--DVDGITGTAILYRVLKLL......G.AKVYPVLPNR-QTGYG 25 .......AMAQKEKVTIWGDF--DADGITSTAVLWEGLGQFfpq...D.SQLTYTIPNRLRESHG 26 .......AHERKEKVLIFGDR--DADGISATTLLFEALCAF......G.LTVCWRVPVA-DEPYG 27 .......HLNNKNKLFVQVDS--DVDGYTSSSIIINYIKKI......C.PKANIHYRIQDGKEHG 28 .......EAKQHRPIVFYTDN--DCDGMLAGSVLMSMCYRL......GiKDFFFFSPLRNAHGYG 29 mvcpkvv----------ILSEGADLDSLSAAYGVLK----L......Y.PDAYLLKPKHLSKKAG 30 i......-VTESSNVIIMGHKFPDMDSIGAAIGILKVAQAN......N.KDGFIVIDPNQIGSSV 31 kl.....--KTFDNFSLYVHVNPDFDAFGAAFAFKAFLAVY......F.PHKKAYVMGS--HNIK 32 ti.....--SLYDTIILHRHVRPDPDAYGSQCGLTEILRET......Y.PEKNIFAVGTPEPSLS 33 .......AIKQFDKIVIFHHVRPDGDCLGAQQGLFHLIKAN......F.KNKEVKCVGN--NNNL 34 .......AIQAHDKIVIFHHIRPDGDCLGAQHGLARLIQTN......F.PHKQVFCVGD--PKHN 35 lk.....--NVKGSILILTHENPDGDSLGSGLALYKFLKKK......G.KEVYIGSKDGVPHFLD 36 .......FIKKYNNFVIIGHKDPDFDCIGSSLALSSFLSRI......G.KNSILLNEGPFIRKEI 37 f......-IDAHRAFAVVGHEKPDGDCVGSSLALASFLRRI......G.KEVELLSAGPFKRREI 38 llsaa..-----ARVGVVCHVHPDADTIGAGLALALVLDGC......G.KRVEVSFAAPATLPES 39 gh.....---QGQRLILVIQDFPDPDALSSAWAFQLIAAQY......E.IQCDIVYAGTLSHQEN 40 ee.....--EKKAPLLILTHINPDPDAIASAMALKTLAERW......G.VDSDIAYGGNIGYDEN 41 e......-SLRGKRLGIFTHDNPDPDSMSSAYALREIAKQF......D.VIADILYYGEILHQKN 42 i......-KEKTDTLLIVMHDNPDPDCMASASALAVIAQSI......G.LKTQIVYGGDITHHQN 43 l......--NRDEGIILLCHHNADPDSLGSAIAFSNFLLSK......G.FSRIRIGVAQSIASYS 44 e......-YLKRDEVLFLCHHNADPDAVGSCVALKYLASQL......N.PNGKFRISADSVSKLS 45 .......EIAIHGSFLLLGHEHPDEDCIASLVAFALLLTRC......N.KRVEICCQGPIRVQIS 46 q......-------VYHLSHI--DLDGYACQLVSKQFFKNI......Q.-----CYNANYGREVS 47 myh....---------LYSHN--DLDGVGCGIVAKLA---F......G.KDVEIRYNSV--NGLN 48 .......AVLDGRPIIIRHHA--DTDGYCGGIALEKAILPIidkfaiD.VDAIWHFFKR--RPSK 49 .......AVYDGRSILVRHHA--DADGICAGVAIEKAVLPLlrdlnpS.TDAEWHYFKR--APSK 50 .......AIFEGRPIILRHHA--DTDGYTAGVALETAIVPLieevapD.PDARWHLFKR--RPSR 51 .......AIYESRPVIIRHHW--DADGTCGGVALEKALTDLvervhsD.SEAKYYLVKR--RVSR 52 rs.....--YAGGGVTVVHHN--DADGLCSGALLKKLCEYC......G.FEAELICIEK------ 53 i......-LNHYGYIRVITHH--DTDGLSSGGILAKMLMRT......N.KLFHLTVVEHLSKEVI 54 .......HLERGNIIRIISHN--DADGLSAAGVVARAISSM......N.GQFHISILSRLKKEF- 55 .......HIELGHTIRIISHR--DADGITSAAILAKALARE......G.AKFHISIVKQ------ 56 l......-VARHDFIRIYTHH--DADGISAGAIIAKALLKA......G.KAFHITFLKGLNEPFE 57 r......-ILKNEEVLVVTHI--DADGITAGTIAHTSLLRA......G.VESGIRFVKQLDESEI 58 qn.....--NKNNKILIVTHI--DTDGLTSRAILQKLAERL......N.LDADFMFLKQ------ 59 m......-VESSETVTVYSHT--DCDGITAATVLSKVLERL......D.MDHEVRIININEVPEV 60 mismn..--------LIIHHW--DTDGITSAALLIKALELD......E.FRNMSPPIGE------ 61 a......-MRTNTEILVVGDY--DADGVISSAIMAKFFESL......NyKHVRIAIPNRFMDGYG 62 .......AIVNSQQICIFADY--DVDGATSAALLKHFLRDL......N.IICDIYVPDRIYEGYG 63 .......AISQQEKIMIYGDY--DADGVTSTSVMLHTLQKL......S.AQVDFYIPDRFKEGYG 64 a......-FREGTRIIVVGDF--DADGATSTALSVLAMRSL......GcSNIDYLVPNRFEDGYG 65 .......ALADNRRIVIVGDF--DADRATSTALTVLALRSM......AaREVQYLVPNRFEDGYG 66 ay.....--QPQQKIVIVGDF--DADGATSTALSVLALRQL......GfSDVDYLVPNRFEQGYG 67 .......AIKNNENILIFGDK--DADGITATIIMYETLKDF......G.LNVSYKIPSN-GEFYG 68 a......-RDRKEHVMIYGDS--DVDGMTGVALLVEFLRDI......D.VHVSYFFLGAILKQHG 69 .......AKERNEHVMVYGDS--DVDGMTGVALLVEFLRSI......D.MKVSYCFLGALLKHYG 70 a......-KANNEHVMIYGDG--DVDGITGVTLIVEFLQIL......G.VKTSYCCSGTLFKQHG 71 .......AVLKKKRIIIYGDY--DVDGITGTAILYRVLKLL......G.AKVYPVLPNR-QTGYG 72 .......AMAQKEKVTIWGDF--DADGITSTAVLWEGLGQFfpq...D.SQLTYTIPNRLRESHG 73 .......AHERKEKVLIFGDR--DADGISATTLLFEALCAF......G.LTVCWRVPVA-DEPYG 74 .......HLNNKNKLFVQVDS--DVDGYTSSSIIINYIKKI......C.PKANIHYRIQDGKEHG 75 .......EAKQHRPIVFYTDN--DCDGMLAGSVLMSMCYRL......GiKDFFFFSPLRNAHGYG 76 mvcpkvv----------ILSEGADLDSLSAAYGVLK----L......Y.PDAYLLKPKHLSKKAG 77 i......-VTESSNVIIMGHKFPDMDSIGAAIGILKVAQAN......N.KDGFIVIDPNQIGSSV 78 kl.....--KTFDNFSLYVHVNPDFDAFGAAFAFKAFLAVY......F.PHKKAYVMGS--HNIK 79 ti.....--SLYDTIILHRHVRPDPDAYGSQCGLTEILRET......Y.PEKNIFAVGTPEPSLS 80 .......AIKQFDKIVIFHHVRPDGDCLGAQQGLFHLIKAN......F.KNKEVKCVGN--NNNL 81 .......AIQAHDKIVIFHHIRPDGDCLGAQHGLARLIQTN......F.PHKQVFCVGD--PKHN 82 lk.....--NVKGSILILTHENPDGDSLGSGLALYKFLKKK......G.KEVYIGSKDGVPHFLD 83 .......FIKKYNNFVIIGHKDPDFDCIGSSLALSSFLSRI......G.KNSILLNEGPFIRKEI 84 f......-IDAHRAFAVVGHEKPDGDCVGSSLALASFLRRI......G.KEVELLSAGPFKRREI 85 llsaa..-----ARVGVVCHVHPDADTIGAGLALALVLDGC......G.KRVEVSFAAPATLPES 86 gh.....---QGQRLILVIQDFPDPDALSSAWAFQLIAAQY......E.IQCDIVYAGTLSHQEN 87 ee.....--EKKAPLLILTHINPDPDAIASAMALKTLAERW......G.VDSDIAYGGNIGYDEN 88 e......-SLRGKRLGIFTHDNPDPDSMSSAYALREIAKQF......D.VIADILYYGEILHQKN 89 i......-KEKTDTLLIVMHDNPDPDCMASASALAVIAQSI......G.LKTQIVYGGDITHHQN 90 l......--NRDEGIILLCHHNADPDSLGSAIAFSNFLLSK......G.FSRIRIGVAQSIASYS 91 e......-YLKRDEVLFLCHHNADPDAVGSCVALKYLASQL......N.PNGKFRISADSVSKLS 92 .......EIAIHGSFLLLGHEHPDEDCIASLVAFALLLTRC......N.KRVEICCQGPIRVQIS 93 q......-------VYHLSHI--DLDGYACQLVSKQFFKNI......Q.-----CYNANYGREVS 94 myh....---------LYSHN--DLDGVGCGIVAKLA---F......G.KDVEIRYNSV--NGLN 60 70 80 90 | | | | 1 APFYELEDVT........KDLVFSIEDAL...KFGQKLPLIVLIDN...GSTD....E......D 2 APFYELEDVV........KDLSYALEDLE...RHGQKLPLLVLLDN...GSTE....E......D 3 APFYELEDVL........KDIIFMMEDHM...RFGDELPLVVIVDN...GGTT....E......D 4 APFYELEDVV........RDLDESLEDAE...RHGDKIPLVVLVDN...GSGL....E......D 5 ----------........---VYPAVVEK...IHSSRDGMIIYTDL...GG--....L......A 6 EKLAKENEV-........-----------...----NKPLFIFADM...GS--....-......- 7 ----------........--------IKK...LSGEKYSLFFFCDM...GS--....-......- 8 ----------........---VSEELVRQ...LKDEEYKIIIFSDL...GSGS....L......S 9 YE--------........-----------...----QGELLLFADM...GS--....-......- 10 EAIKD-----........-----------...----ENTFVWFTDI...GS--....-......- 11 ----------........---ITIETIND...IPFKDYDLIIFADL...GSGQlkmiK......E 12 EL--------........-----------...----SSDLTIFSDL...GS--....-......- 13 ----------........---FRFDDRIR...KAIEHAERVYILDL...NLPY....D......V 14 ISKKFLEKH-........-----------...----HAPLIITVDN...GI--....N......A 15 PT--------........-----PLAMQK...IKGNGTELLITVDC...GA--....M......A 16 PN--------........-----EQAFRS...IKERGFSLIITVDT...GI--....A......A 17 LS--------........-----PEVVDQ...AHARGAQLIVTVDN...GI--....S......S 18 LS--------........-----PEVVAQ...APAKGAELIVTVDN...GI--....S......S 19 LS--------........-----IPVAEM...AIEKGVQLLMTVDN...GV--....S......S 20 LS--------........-----NELINT...ALEKKISLIITVDN...GI--....S......S 21 ET--------........-----STLIAK...LKEEGITLLITVDC...GI--....T......A 22 EP--------........-----SSLIAK...MKEEKVTLLITVDC...GI--....T......A 23 ET--------........-----ASLISQ...MLQDGISLLITVDC...GI--....T......A 24 LN--------........------KELMS...IFEKYGDFLITVDN...GT--....-......- 25 LNRPGLERL-........-----------...-ATQGTKLIVTCDT...GS--....T......N 26 LS--------........-----CNAVDE...HAAAGGTLIVTVDC...GI--....S......N 27 IF--------........---------ID...TIPDDVDLVIIPDA...GS--....S......Q 28 FTDLALNDLLsqp9fnpkTNQLVRLDCIK...NQFQKNPLLFSADL...GADLa...A......N 29 EVFKKYRDK-........------FRVIE...DLPDCFE-LVLVDT...HF--....-......- 30 QRLIGEIKKY........EELWSRFITPEeamEISNDDTLLVIVDT...HK--....P......S 31 ADGKDLFPF-........-----EAAPID...DAFVKNSLAIIFDT...S---....N......Q 32 FL--------........----YSLDEVD...NETYEGALVIVCDT...A---....N......Q 33 FSFINMTF--........------TNQID...ESFLKEALAIVVDA...NYKN....R......I 34 FPWLEMVFTP........KEQITPELM--...----QQALAVIVDA...NYKE....R......I 35 FL--------........---PGVEDVIN...PDGKFYDVGIVVDA...SG--....-......- 36 VPFKD-----........---KFLSEWPN...IEISEYS-VIILDC...SI-L....D......R 37 AAYATLFR--........-----PSLSAQ...IRPSDQTAVIVVDC...SE-L....S......R 38 LRSLPGCHL-........------LVRPE...VMRRDVDLVVTVDI...PS-V....D......R 39 IALVKLTGLP........AKRWGPQMLKD...IDLSDYQGCVLVDS...QGTN....S......Q 40 KAMINLLGI-........----KLLNVED...IDLDNYCVIAVIDT...ST--....-......- 41 RAMVNLLEI-........----PMIRAPE...VDLSHYDAFAIVDS...SG--....-......- 42 RAMVNVLGME........FRKVSR---GS...YEIKRHKAIAIVDA...QP--....N......G 43 RRLVALSRVP........IEKDPVI----...----KENVIFIFDT...SS--....-......- 44 RNILNEIG--........-----ERVDIE...IYPKLPETVFIVDT...AS--....I......N 45 FL---IDICL........YNGIAVHLDTQ...TVPRMPDALVILDTpnpGMIY....A......P 46 ARIYEILNA-........---------IA...QSKESEFLILVSDL...NLNL....NeaeylqD 47 AQ--------........---VQYFLEKA...KESNRQDALFITDL...AVNE....E......N 48 APFYELEDVT........KDLVFSIEDAL...KFGQKLPLIVLIDN...GSTD....E......D 49 APFYELEDVV........KDLSYALEDLE...RHGQKLPLLVLLDN...GSTE....E......D 50 APFYELEDVL........KDIIFMMEDHM...RFGDELPLVVIVDN...GGTT....E......D 51 APFYELEDVV........RDLDESLEDAE...RHGDKIPLVVLVDN...GSGL....E......D 52 ----------........---VYPAVVEK...IHSSRDGMIIYTDL...GG--....L......A 53 EKLAKENEV-........-----------...----NKPLFIFADM...GS--....-......- 54 ----------........--------IKK...LSGEKYSLFFFCDM...GS--....-......- 55 ----------........---VSEELVRQ...LKDEEYKIIIFSDL...GSGS....L......S 56 YE--------........-----------...----QGELLLFADM...GS--....-......- 57 EAIKD-----........-----------...----ENTFVWFTDI...GS--....-......- 58 ----------........---ITIETIND...IPFKDYDLIIFADL...GSGQlkmiK......E 59 EL--------........-----------...----SSDLTIFSDL...GS--....-......- 60 ----------........---FRFDDRIR...KAIEHAERVYILDL...NLPY....D......V 61 ISKKFLEKH-........-----------...----HAPLIITVDN...GI--....N......A 62 PT--------........-----PLAMQK...IKGNGTELLITVDC...GA--....M......A 63 PN--------........-----EQAFRS...IKERGFSLIITVDT...GI--....A......A 64 LS--------........-----PEVVDQ...AHARGAQLIVTVDN...GI--....S......S 65 LS--------........-----PEVVAQ...APAKGAELIVTVDN...GI--....S......S 66 LS--------........-----IPVAEM...AIEKGVQLLMTVDN...GV--....S......S 67 LS--------........-----NELINT...ALEKKISLIITVDN...GI--....S......S 68 ET--------........-----STLIAK...LKEEGITLLITVDC...GI--....T......A 69 EP--------........-----SSLIAK...MKEEKVTLLITVDC...GI--....T......A 70 ET--------........-----ASLISQ...MLQDGISLLITVDC...GI--....T......A 71 LN--------........------KELMS...IFEKYGDFLITVDN...GT--....-......- 72 LNRPGLERL-........-----------...-ATQGTKLIVTCDT...GS--....T......N 73 LS--------........-----CNAVDE...HAAAGGTLIVTVDC...GI--....S......N 74 IF--------........---------ID...TIPDDVDLVIIPDA...GS--....S......Q 75 FTDLALNDLLsqp9fnpkTNQLVRLDCIK...NQFQKNPLLFSADL...GADLa...A......N 76 EVFKKYRDK-........------FRVIE...DLPDCFE-LVLVDT...HF--....-......- 77 QRLIGEIKKY........EELWSRFITPEeamEISNDDTLLVIVDT...HK--....P......S 78 ADGKDLFPF-........-----EAAPID...DAFVKNSLAIIFDT...S---....N......Q 79 FL--------........----YSLDEVD...NETYEGALVIVCDT...A---....N......Q 80 FSFINMTF--........------TNQID...ESFLKEALAIVVDA...NYKN....R......I 81 FPWLEMVFTP........KEQITPELM--...----QQALAVIVDA...NYKE....R......I 82 FL--------........---PGVEDVIN...PDGKFYDVGIVVDA...SG--....-......- 83 VPFKD-----........---KFLSEWPN...IEISEYS-VIILDC...SI-L....D......R 84 AAYATLFR--........-----PSLSAQ...IRPSDQTAVIVVDC...SE-L....S......R 85 LRSLPGCHL-........------LVRPE...VMRRDVDLVVTVDI...PS-V....D......R 86 IALVKLTGLP........AKRWGPQMLKD...IDLSDYQGCVLVDS...QGTN....S......Q 87 KAMINLLGI-........----KLLNVED...IDLDNYCVIAVIDT...ST--....-......- 88 RAMVNLLEI-........----PMIRAPE...VDLSHYDAFAIVDS...SG--....-......- 89 RAMVNVLGME........FRKVSR---GS...YEIKRHKAIAIVDA...QP--....N......G 90 RRLVALSRVP........IEKDPVI----...----KENVIFIFDT...SS--....-......- 91 RNILNEIG--........-----ERVDIE...IYPKLPETVFIVDT...AS--....I......N 92 FL---IDICL........YNGIAVHLDTQ...TVPRMPDALVILDTpnpGMIY....A......P 93 ARIYEILNA-........---------IA...QSKESEFLILVSDL...NLNL....NeaeylqD 94 AQ--------........---VQYFLEKA...KESNRQDALFITDL...AVNE....E......N 100 110 120 130 140 150 | | | | | | 1 IPAISKAKAYGIEV.IVIDHH.FPGEVVDgkv.EVDDYVDAHVNPYLVGG.DSNLTAGVLGTEIA 2 ILALMKAKIYDIEI.VVVDHH.YPGEVQDgrv.EVDEYVDTHVNPYLVGG.DSQITAGSLSVEIA 3 IPAYKRLKAYGVKI.VVIDHH.DPRDWISedkaKVDEYVDVHVNPHH---.---VKRGYYELTAG 4 VPAIRQFLLFGADV.ITIDHH.FPDE---....EVDSYLLYHVNPYKVGG.DSNYTSGVLCVEIA 5 ADMIDKINAGKSMV.LIIDHH.PAKD---....-IDSDYVHVLDPELAGI.SGD-----VFVSAS 6 -GQIEEIIKHNFNA.IILDHH.PPVIKDS....F-INENIIQLNPHIFGV.DGS-----REITAS 7 -AYLEEISRLKGDV.IVADHH.QPSE---....SEAGPHVVHINPHLHGL.DGS-----RDLSAS 8 LIGEHL---KDKSV.VILDHH.PPEP---....VETHEKHILANPVQFGA.NSV-----RDLSGS 9 -GYADLISQVDTDV.VILDHH.IPNG--E....IRPKRNLAHVNPHLVGM.DGT-----FELSAS 10 ---GVLNMLDGIEF.AITDHH.LPQS---....----HHPMQLNPHDFGY.DGA-----FELSGA 11 KLDELNLSDKRDKI.IILDHH.QPEE---....IKIPKTIIHINPLTIAK.SGA------EICGA 12 GQRVHENLKSNSRV.LILDHH.PPVRKMNf...TAPSGDFLEINPIFYGM.DGS-----THVSGG 13 EGIE-------KET.VFIDHH.IQPK---....-IKNPRVRQINPSLEGKeSPSASFVVSEYFDV 14 FEAARFCKEKNYTL.IITDHH.CLHH---....DEVPDAYAVINPKQ---.-PDCDFIQKEVCGA 15 HDALKYAKDVKLDV.IVIDHH.ISTE---....-ILPDAVAIVNPNR---.-IDETSEYKYLAAV 16 VHEAKVAKELGLDV.IITDHH.EPGP---....-ELPDVRAIVHPKQ---.-PGCTYPFKELAGV 17 HAGVEHARSLGIPV.IVTDHH.LPGD---....-TLPAAEAIINPNL---.-RDCNFPSKSLAGV 18 HAGVDDAHRRGIAV.VVTDHH.LPGE---....-TLPAAEAMINPNL---.-SDCAFPSKALAGV 19 FDGVAFLKEKGIRV.LVTDHH.LPPE---....-TLPPADAIVNPNL---.-SQCGFPSKSLAGV 20 IEEINYANSKGIEI.IITDHH.LPGE---....-NFKTENIVINPHL---.-KDDKYPFKEIAGC 21 GKEVSDITRQGIDV.IITDHH.MPTG---....-KIPHCVATLNPKL---.-RDHTYPNRELTGV 22 GKEVSDINKQGIDV.IITDHH.MPTG---....-KIPHCIATLNPKL---.-RDRAYPNKELTGV 23 GKEVHAINKQGIDV.IVTDHH.MPTG---....-KLPHCVAMLNPKL---.-DKNPYPNKELTGV 24 -SAVEEIDQSSLET.VVIDHH.NVPP---....-RIPKKALIVNPKV---.-GAKREGLKALSSS 25 LDEIVYAQQLGMDV.IVTDHH.TLPD---....-DRPEVVAIINPRY---.-FADGHPLFNLSGV 26 RAEIAYARHRGIDV.LVIDHH.AAPE---....--TLPDAIIINAKV---.-PGAGYPHEFLSGC 27 FEEHEALNKRGTEI.IVIDHH.ECER---....--VSEHAIVVNNQL---.--SPNYSNKTLTGA 28 TELQEILLEHFEQC.IITDHH.KSFE-VD....WIDENKIAYINLND---.-EKDANYYSGAFTS 29 -LPEGLPRERIKRI.IVYDHH.PIGD---....--VKEFEGKIEKV----.-GAATTLVVEEIKE 30 LVMEERLVNKIEHI.VVIDHH.RRGE--E....FIRDPLLVYMEPYA---.-SSTAELVTELLEY 31 ERVLTQKHKLAKET.VRIDHH.PKTE---....--SFADLEWIDPAF---.-SAAAEMVGYLILQ 32 ERIDDQRYPSGAKL.MKIDHH.PNED---....--PYGDLLWVDTSA---.-SSVSEMIYELYLE 33 ELRELLDKNLFKAV.LRIDHH.PNED---....-DLNTSFNFVEESY---.-VACCEQIVEMATV 34 ECRDLLDQNQFKAV.LRIDHH.PNED---....-DLNTTHNFVDASY---.-IAAAEQVVDLAVQ 35 -FYRVGKEVKVGKR.IRIDHH.VGGE---....--FYGMHDYIDPTA---.-PATAALVYEIIKN 36 IGDEFIFYVKNMPT.LVIDHH.MSGE---....--KLECEGYIDPFA---.-PSTTFLIEKLIRE 37 VGAELASQLAPFAR.AFIDHH.ETCG---....--DHCAHSFVVKTA---.-PSTTTLVQTLIET 38 LGALGDLTDSGREL.LVIDHH.ASND---....--LFGTANFIDPSA---.-DSTTTMVAEILDA 39 LMPLVQEANIPV-V.VIIDHH.SPQD--E....VEAEGAFVDIRPSS---.-RSTATILTEYLQG 40 -SKQLPIELPNID-.IIIDHH.NNTD---....--LTAKYMDVRPEV---.-GATASILTQYLME 41 -PGVNNSIPPDIDIsIVIDHH.PAEK---....--VVAEFVDLREDV---.-GATATILTEYIKE 42 NITILDEEDLNKIE.IIIDHHqILQNLRE....KLPPNCFVDIRTDV---.-NATSSIMAEYLKA 43 IEQLEPIEVPPAKI.VVIDHH.VEKE---....NPIPADVAIIDPTR---.-TSTAEIVWELFKK 44 QLKVNFDELKEREV.ILIDHH.KKTD---....LADICKYYIIKEDY---.-PSTSEIIAEIFKE 45 PSCRLLLSDSTIRK.IELDHH.LFANAAC....CGDPGYSLIARA-----.-SSTCEIIAYLCYK 46 KIQEHRLQNKNIQI.QLLDHH.ISGKEVA....ESFHWYFLDINRCA---.----TKIVYEFLKK 47 EERLNEYVHAGGKV.KLIDHH.KTALHLN....E-HEWGFVQVEYDDGRL.TSATSLLYGYLIEN 48 IPAISKAKAYGIEV.IVIDHH.FPGEVVDgkv.EVDDYVDAHVNPYLVGG.DSNLTAGVLGTEIA 49 ILALMKAKIYDIEI.VVVDHH.YPGEVQDgrv.EVDEYVDTHVNPYLVGG.DSQITAGSLSVEIA 50 IPAYKRLKAYGVKI.VVIDHH.DPRDWISedkaKVDEYVDVHVNPHH---.---VKRGYYELTAG 51 VPAIRQFLLFGADV.ITIDHH.FPDE---....EVDSYLLYHVNPYKVGG.DSNYTSGVLCVEIA 52 ADMIDKINAGKSMV.LIIDHH.PAKD---....-IDSDYVHVLDPELAGI.SGD-----VFVSAS 53 -GQIEEIIKHNFNA.IILDHH.PPVIKDS....F-INENIIQLNPHIFGV.DGS-----REITAS 54 -AYLEEISRLKGDV.IVADHH.QPSE---....SEAGPHVVHINPHLHGL.DGS-----RDLSAS 55 LIGEHL---KDKSV.VILDHH.PPEP---....VETHEKHILANPVQFGA.NSV-----RDLSGS 56 -GYADLISQVDTDV.VILDHH.IPNG--E....IRPKRNLAHVNPHLVGM.DGT-----FELSAS 57 ---GVLNMLDGIEF.AITDHH.LPQS---....----HHPMQLNPHDFGY.DGA-----FELSGA 58 KLDELNLSDKRDKI.IILDHH.QPEE---....IKIPKTIIHINPLTIAK.SGA------EICGA 59 GQRVHENLKSNSRV.LILDHH.PPVRKMNf...TAPSGDFLEINPIFYGM.DGS-----THVSGG 60 EGIE-------KET.VFIDHH.IQPK---....-IKNPRVRQINPSLEGKeSPSASFVVSEYFDV 61 FEAARFCKEKNYTL.IITDHH.CLHH---....DEVPDAYAVINPKQ---.-PDCDFIQKEVCGA 62 HDALKYAKDVKLDV.IVIDHH.ISTE---....-ILPDAVAIVNPNR---.-IDETSEYKYLAAV 63 VHEAKVAKELGLDV.IITDHH.EPGP---....-ELPDVRAIVHPKQ---.-PGCTYPFKELAGV 64 HAGVEHARSLGIPV.IVTDHH.LPGD---....-TLPAAEAIINPNL---.-RDCNFPSKSLAGV 65 HAGVDDAHRRGIAV.VVTDHH.LPGE---....-TLPAAEAMINPNL---.-SDCAFPSKALAGV 66 FDGVAFLKEKGIRV.LVTDHH.LPPE---....-TLPPADAIVNPNL---.-SQCGFPSKSLAGV 67 IEEINYANSKGIEI.IITDHH.LPGE---....-NFKTENIVINPHL---.-KDDKYPFKEIAGC 68 GKEVSDITRQGIDV.IITDHH.MPTG---....-KIPHCVATLNPKL---.-RDHTYPNRELTGV 69 GKEVSDINKQGIDV.IITDHH.MPTG---....-KIPHCIATLNPKL---.-RDRAYPNKELTGV 70 GKEVHAINKQGIDV.IVTDHH.MPTG---....-KLPHCVAMLNPKL---.-DKNPYPNKELTGV 71 -SAVEEIDQSSLET.VVIDHH.NVPP---....-RIPKKALIVNPKV---.-GAKREGLKALSSS 72 LDEIVYAQQLGMDV.IVTDHH.TLPD---....-DRPEVVAIINPRY---.-FADGHPLFNLSGV 73 RAEIAYARHRGIDV.LVIDHH.AAPE---....--TLPDAIIINAKV---.-PGAGYPHEFLSGC 74 FEEHEALNKRGTEI.IVIDHH.ECER---....--VSEHAIVVNNQL---.--SPNYSNKTLTGA 75 TELQEILLEHFEQC.IITDHH.KSFE-VD....WIDENKIAYINLND---.-EKDANYYSGAFTS 76 -LPEGLPRERIKRI.IVYDHH.PIGD---....--VKEFEGKIEKV----.-GAATTLVVEEIKE 77 LVMEERLVNKIEHI.VVIDHH.RRGE--E....FIRDPLLVYMEPYA---.-SSTAELVTELLEY 78 ERVLTQKHKLAKET.VRIDHH.PKTE---....--SFADLEWIDPAF---.-SAAAEMVGYLILQ 79 ERIDDQRYPSGAKL.MKIDHH.PNED---....--PYGDLLWVDTSA---.-SSVSEMIYELYLE 80 ELRELLDKNLFKAV.LRIDHH.PNED---....-DLNTSFNFVEESY---.-VACCEQIVEMATV 81 ECRDLLDQNQFKAV.LRIDHH.PNED---....-DLNTTHNFVDASY---.-IAAAEQVVDLAVQ 82 -FYRVGKEVKVGKR.IRIDHH.VGGE---....--FYGMHDYIDPTA---.-PATAALVYEIIKN 83 IGDEFIFYVKNMPT.LVIDHH.MSGE---....--KLECEGYIDPFA---.-PSTTFLIEKLIRE 84 VGAELASQLAPFAR.AFIDHH.ETCG---....--DHCAHSFVVKTA---.-PSTTTLVQTLIET 85 LGALGDLTDSGREL.LVIDHH.ASND---....--LFGTANFIDPSA---.-DSTTTMVAEILDA 86 LMPLVQEANIPV-V.VIIDHH.SPQD--E....VEAEGAFVDIRPSS---.-RSTATILTEYLQG 87 -SKQLPIELPNID-.IIIDHH.NNTD---....--LTAKYMDVRPEV---.-GATASILTQYLME 88 -PGVNNSIPPDIDIsIVIDHH.PAEK---....--VVAEFVDLREDV---.-GATATILTEYIKE 89 NITILDEEDLNKIE.IIIDHHqILQNLRE....KLPPNCFVDIRTDV---.-NATSSIMAEYLKA 90 IEQLEPIEVPPAKI.VVIDHH.VEKE---....NPIPADVAIIDPTR---.-TSTAEIVWELFKK 91 QLKVNFDELKEREV.ILIDHH.KKTD---....LADICKYYIIKEDY---.-PSTSEIIAEIFKE 92 PSCRLLLSDSTIRK.IELDHH.LFANAAC....CGDPGYSLIARA-----.-SSTCEIIAYLCYK 93 KIQEHRLQNKNIQI.QLLDHH.ISGKEVA....ESFHWYFLDINRCA---.----TKIVYEFLKK 94 EERLNEYVHAGGKV.KLIDHH.KTALHLN....E-HEWGFVQVEYDDGRL.TSATSLLYGYLIEN 160 170 180 | | | 1 --------RMINP..DV.......E........DEIKHIPGIAVVGD---hak...... 2 --------KMINP..EI.......A........ERILHLPGIAAVGD---han...... 3 MLATEVARYVNPA..VE.......D........KIKHLPAIAG-------tgdrsk... 4 -----------RM..IS.......D........LDMKHLAAISVVGD---rae...... 5 SLNYIFFRAVAGE..E-.......A........KKYAYIAVLGSVGDY--hd....... 6 GVCYLV----ARE..FG.......Y........YDLSVLAIVGIIGDMQ-y........ 7 GTAYL-----ATR..LL.......N........RKTAPLALVGALGDMQ-y........ 8 GVSYFFAREL--N..EM.......N........KDLAYIAIVGAVGDMQ-e........ 9 GVCYFFA---NEL..GR.......N........RELASVALIGALGDKQR......... 10 TTTYLVSKYLRNG..RTlfdyendN........SDLLPISIVGAVGDLQ-d........ 11 GVSYLFAKAINND..WI.......D........--LAKYAVLGAVGDIQN......... 12 GLTYLL----ARE..FG.......Y........RDLSWMGLLAAVGDMQN......... 13 -------------..--.......-........--WNTWTALGAVGDVG-e........ 14 LVAFYLCYGIHQL..LG.......Kekshs...SELLCLAGVATIADMMP......... 15 GVTFLFATAILSN..LK.......Krny13pnlMKYLDLVALGTVCDMM-k........ 16 GVAFKLAHALLGE..LP.......D........-ELLDLAAIGTIADLV-p........ 17 GVAFYLMLALRTF..LR.......Dqgw14pnlAELLDLVALGTVADVV-p........ 18 GVAFYLMMALRAN..LR.......Ecgw14pnlAELLDLVALGTVADVV-p........ 19 GVAFYLMLAVRAK..FR.......Elgi12pnfTDLLDLVALGTIADVV-p........ 20 CVSFKACLA----..--.......-........-----------------ls165nmp. 21 GVAFKLARGVLNA..LI.......Srnl11gslKKLLDLVTLGTITDVG-v........ 22 GVAFKLARGVLNA..LR.......Kenp9kvdtKHLLDLVTLGTVTDVG-t........ 23 GVAFKLVCATYEE..LI.......Qqda11idlLRFLDLVSLGTIADVGR......... 24 ALSFYLGSALIRE..FNlded...P........RNFLDLVALGLLADYMP......... 25 AVAFKLVEALYNQ..YP.......Tvpqqpl..EDLLDLVAIGLIADL--vt....... 26 ATAWKVVTA----..--.......-........-----------------lr167lmv. 27 GMAYKFCQAIDEK..LN.......Knea.....EQFLDLVSIGNIAD---sad...... 28 ALVFSQIFQTQTT..PL.......E........EELIAITLLS-------drid..... 29 ----------KGI..DI.......N........PRDATLLAFGIYEDTGN......... 30 --------QPKRL..KI.......N........MIEATALLAGIIVDT--ks....... 31 ----------MGY..EL.......N........AEMAAYIYAGIITDTQR......... 32 GKE-------HGW..KL.......N........TKAAELIYAGIVGDTGR......... 33 ----------AKW..TI.......P........PVAATLLYIGIYTDSN-r........ 34 ----------AKW..KL.......S........PPAATALYLGIYTDSN-r........ 35 W---------DET..AI.......D........KDIATCIYTGLATDTG-f........ 36 ----------FGH..DL.......T........KEEAWYILVGFCTDTG-f........ 37 ----------MAG..SL.......E........AAEARALFLGLATDTG-f........ 38 ----------WGK..PI.......D........PRVAHCIYAGLATDTG-s........ 39 GMLDFN----SSN..PT.......H........VKCATALMHGLRSDTI-n........ 40 ----------LDI..EP.......S........RNLATALFYGIQSDT--dy....... 41 ----------LKI..TP.......S........KILATALFFGIKS----etde..... 42 ----------LEI..PI.......T........ETLATALFYGMYIDT--kk....... 43 -----------FN..YS.......D........ENSAKALLAGIISDTS-n........ 44 ----------LNI..FP.......P........KNVRIALLCGIVYDT--kh....... 45 LARNHAQRTALGIrnLY.......S........RNVVLSILTGMIGD---akt...... 46 HYA----------..--.......-........-----------------ile19vns. 47 G------------..--.......-........-----------------fmk17vrq. 48 --------RMINP..DV.......E........DEIKHIPGIAVVGD---hak...... 49 --------KMINP..EI.......A........ERILHLPGIAAVGD---han...... 50 MLATEVARYVNPA..VE.......D........KIKHLPAIAG-------tgdrsk... 51 -----------RM..IS.......D........LDMKHLAAISVVGD---rae...... 52 SLNYIFFRAVAGE..E-.......A........KKYAYIAVLGSVGDY--hd....... 53 GVCYLV----ARE..FG.......Y........YDLSVLAIVGIIGDMQ-y........ 54 GTAYL-----ATR..LL.......N........RKTAPLALVGALGDMQ-y........ 55 GVSYFFAREL--N..EM.......N........KDLAYIAIVGAVGDMQ-e........ 56 GVCYFFA---NEL..GR.......N........RELASVALIGALGDKQR......... 57 TTTYLVSKYLRNG..RTlfdyendN........SDLLPISIVGAVGDLQ-d........ 58 GVSYLFAKAINND..WI.......D........--LAKYAVLGAVGDIQN......... 59 GLTYLL----ARE..FG.......Y........RDLSWMGLLAAVGDMQN......... 60 -------------..--.......-........--WNTWTALGAVGDVG-e........ 61 LVAFYLCYGIHQL..LG.......Kekshs...SELLCLAGVATIADMMP......... 62 GVTFLFATAILSN..LK.......Krny13pnlMKYLDLVALGTVCDMM-k........ 63 GVAFKLAHALLGE..LP.......D........-ELLDLAAIGTIADLV-p........ 64 GVAFYLMLALRTF..LR.......Dqgw14pnlAELLDLVALGTVADVV-p........ 65 GVAFYLMMALRAN..LR.......Ecgw14pnlAELLDLVALGTVADVV-p........ 66 GVAFYLMLAVRAK..FR.......Elgi12pnfTDLLDLVALGTIADVV-p........ 67 CVSFKACLA----..--.......-........-----------------ls165nmp. 68 GVAFKLARGVLNA..LI.......Srnl11gslKKLLDLVTLGTITDVG-v........ 69 GVAFKLARGVLNA..LR.......Kenp9kvdtKHLLDLVTLGTVTDVG-t........ 70 GVAFKLVCATYEE..LI.......Qqda11idlLRFLDLVSLGTIADVGR......... 71 ALSFYLGSALIRE..FNlded...P........RNFLDLVALGLLADYMP......... 72 AVAFKLVEALYNQ..YP.......Tvpqqpl..EDLLDLVAIGLIADL--vt....... 73 ATAWKVVTA----..--.......-........-----------------lr167lmv. 74 GMAYKFCQAIDEK..LN.......Knea.....EQFLDLVSIGNIAD---sad...... 75 ALVFSQIFQTQTT..PL.......E........EELIAITLLS-------drid..... 76 ----------KGI..DI.......N........PRDATLLAFGIYEDTGN......... 77 --------QPKRL..KI.......N........MIEATALLAGIIVDT--ks....... 78 ----------MGY..EL.......N........AEMAAYIYAGIITDTQR......... 79 GKE-------HGW..KL.......N........TKAAELIYAGIVGDTGR......... 80 ----------AKW..TI.......P........PVAATLLYIGIYTDSN-r........ 81 ----------AKW..KL.......S........PPAATALYLGIYTDSN-r........ 82 W---------DET..AI.......D........KDIATCIYTGLATDTG-f........ 83 ----------FGH..DL.......T........KEEAWYILVGFCTDTG-f........ 84 ----------MAG..SL.......E........AAEARALFLGLATDTG-f........ 85 ----------WGK..PI.......D........PRVAHCIYAGLATDTG-s........ 86 GMLDFN----SSN..PT.......H........VKCATALMHGLRSDTI-n........ 87 ----------LDI..EP.......S........RNLATALFYGIQSDT--dy....... 88 ----------LKI..TP.......S........KILATALFFGIKS----etde..... 89 ----------LEI..PI.......T........ETLATALFYGMYIDT--kk....... 90 -----------FN..YS.......D........ENSAKALLAGIISDTS-n........ 91 ----------LNI..FP.......P........KNVRIALLCGIVYDT--kh....... 92 LARNHAQRTALGIrnLY.......S........RNVVLSILTGMIGD---akt...... 93 HYA----------..--.......-........-----------------ile19vns. 94 G------------..--.......-........-----------------fmk17vrq.