; SAM: prettyalign v3.2 (July 31, 2000) compiled 07/31/00_16:52:38 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequences correspond to the following labels: ; 1 T0123 ; 2 gi|229460|prf||732164A_2:162 ; 3 gi|2194088|pdb|1BEB|A_2:162 ; 4 gi|6980895|pdb|1BSO|A_2:162 ; 5 gi|125911|sp|P02755|LACB_BUBAR_2:162 ; 6 gi|3808097|emb|CAA06532.1|_20:180 ; 7 gi|7766897|pdb|1CJ5|A_4:162 ; 8 gi|165839|gb|AAA31510.1|_20:180 ; 9 gi|6729725|pdb|1BSQ|A_2:162 ; 10 gi|223780|prf||0911271A_2:162 ; 11 gi|125910|sp|P02754|LACB_BOVIN_18:178 ; 12 gi|125912|sp|P02756|LACB_CAPHI_20:180 ; 13 gi|125918|sp|P02757|LACB_SHEEP_20:180 ; 14 gi|89908|pir||S00132_2:162 ; 15 gi|520|emb|CAA32835.1|_18:178 ; 16 gi|346460|pir||A45542_19:178 ; 17 gi|1346407|sp|P04119|LACB_PIG_19:178 ; 18 gi|2851437|sp|P02758|LACB_HORSE_21:180 ; 19 gi|462473|sp|P33687|LACB_FELCA_4:162 ; 20 gi|162748|gb|AAA30411.1|_2:151 ; 21 gi|462475|sp|P33688|LACC_FELCA_4:162 ; 22 gi|462472|sp|P33685|LACA_CANFA_2:160 ; 23 gi|125913|sp|P13613|LACB_EQUAS_3:162 ; 24 gi|72082|pir||LGHO_3:162 ; 25 gi|125905|sp|P21664|LACA_FELCA_3:163 ; 26 gi|4322134|gb|AAD15975.1|_2:155 ; 27 gi|448344|prf||1916447B_3:163 ; 28 gi|462474|sp|P33686|LACC_CANFA_2:160 ; 29 gi|4322130|gb|AAD15971.1|_2:153 ; 30 gi|2119651|pir||S33875_4:161 ; 31 gi|4322132|gb|AAD15973.1|_2:156 ; 32 gi|4322133|gb|AAD15974.1|_2:156 ; 33 gi|1082934|pir||S33878_2:160 ; 34 gi|125904|sp|P19647|LACA_EQUAS_2:161 ; 35 gi|4322131|gb|AAD15972.1|_2:153 ; 36 gi|8134627|sp|Q9XS65|PGHD_CANFA_27:186 ; 37 gi|1196815|gb|AAA88508.1|_26:176 ; 38 gi|111366|pir||S05440_26:176 ; 39 gi|2851599|sp|P07380|LACA_HORSE_20:179 ; 40 gi|3914338|sp|Q29562|PGHD_URSAR_27:186 ; 41 gi|2497698|sp|Q29487|PGHD_FELCA_27:186 ; 42 gi|6178152|dbj|BAA86198.1|_26:186 ; 43 gi|6981430|ref|NP_037147.1|_30:186 ; 44 gi|6678968|ref|NP_032674.1|_21:173 ; 45 gi|7592640|dbj|BAA94343.1|_27:186 ; 46 gi|89160|pir||A25804_1:159 ; 47 gi|4506251|ref|NP_000945.1|_26:186 ; 48 gi|190444|gb|AAA36494.1|_26:186 ; 49 gi|404390|gb|AAB27607.1|_4:164 ; 50 gi|130701|sp|P09466|PAEP_HUMAN_19:179 ; 51 gi|8307686|dbj|BAA96480.1|_22:176 ; 52 gi|8307696|dbj|BAA96485.1|_26:176 ; 53 gi|4884164|emb|CAB43305.1|_27:187 ; 54 gi|1079295|pir||S52354_22:180 ; 55 gi|3914330|sp|O02853|PGHD_BOVIN_29:186 ; 56 gi|1213589|dbj|BAA12075.1|_22:180 ; 57 gi|2119648|pir||I65319_22:176 ; 58 gi|8134628|sp|Q9XSM0|PGHD_SHEEP_30:186 ; 59 gi|2119647|pir||I52504_22:176 ; 60 gi|5107615|pdb|1NGL|A_14:176 ; 61 gi|8307694|dbj|BAA96484.1|_26:176 ; 62 gi|631308|pir||JC2339_32:194 ; 63 gi|7245434|pdb|1DFV|B_13:175 ; 64 gi|4261868|gb|AAD14168.1|S75256_1_13:175 ; 65 gi|1171700|sp|P80188|NGAL_HUMAN_33:195 ; 66 gi|127533|sp|P02761|MUP_RAT_22:176 ; 67 gi|300181|gb|AAB26529.1|_13:175 ; 68 gi|204261|gb|AAA41198.1|_18:172 ; 69 gi|8307688|dbj|BAA96481.1|_22:176 ; 70 gi|8307698|dbj|BAA96486.1|_22:176 ; 71 gi|266472|sp|Q01584|LIPO_BUFMA_21:179 ; 72 gi|127530|sp|P02762|MUP6_MOUSE_21:175 ; 73 gi|127529|sp|P11591|MUP5_MOUSE_22:175 ; 74 gi|8134622|sp|O97921|PGHD_HORSE_27:189 ; 75 gi|5031853|ref|NP_005555.1|_33:195 ; 76 gi|494384|pdb|1MUP|_7:161 ; 77 gi|4505583|ref|NP_002562.1|_2:161 ; 78 gi|72073|pir||UAMS_21:175 ; 79 gi|1839508|gb|AAB47130.1|_3:157 ; 80 gi|127526|sp|P11588|MUP1_MOUSE_21:175 ; 81 gi|127527|sp|P11589|MUP2_MOUSE_21:175 ; 82 gi|8569601|pdb|1DF3|A_3:157 ; 83 gi|8307692|dbj|BAA96483.1|_26:176 ; 84 gi|7767000|pdb|1QQS|A_10:172 ; 85 gi|3483096|gb|AAC33251.1|_20:186 ; 86 gi|91962|pir||S05244_25:176 ; 87 gi|2497700|sp|Q29095|PGHD_PIG_26:184 ; 88 gi|199869|gb|AAA39764.1|_19:173 ; 89 gi|2497699|sp|O09114|PGHD_MOUSE_30:186 ; 90 gi|112209|pir||A32202_30:185 ; 91 gi|127531|sp|P04938|MUP8_MOUSE_3:146 ; 92 gi|72084|pir||LGHO2_2:164 ; 93 gi|7025470|gb|AAF35894.1|AF229030_1_26:175 ; 94 gi|1279615|emb|CAA30059.1|_19:140 ; 95 gi|266619|sp|P30152|NGAL_RAT_34:195 ; 96 gi|576796|gb|AAA53371.1|_26:175 ; 97 gi|127532|sp|P04939|MUPM_MOUSE_25:179 ; 98 gi|1326433|gb|AAB35994.1|_34:195 ; 99 gi|131765|sp|P21760|QSP_CHICK_26:175 ; 100 gi|2119649|pir||I52212_3:145 ; 101 gi|4567048|gb|AAD23569.1|AF121346_1_26:175 ; 102 gi|211503|gb|AAA48677.1|_26:175 ; 103 gi|7657407|ref|NP_055396.1|_20:166 ; 104 gi|132403|sp|P18902|RETB_BOVIN_6:174 ; 105 gi|7657405|ref|NP_055397.1|_21:166 ; 106 gi|494079|pdb|1HBQ|_6:174 ; 107 gi|7766863|pdb|1EW3|A_5:154 ; 108 gi|6900083|emb|CAB71326.1|_21:166 ; 109 gi|3121758|sp|Q95182|ALL1_HORSE_26:176 ; 110 gi|1421027|pdb|1RLB|E_6:174 ; 111 gi|1542847|dbj|BAA13453.1|_26:186 ; 112 gi|731102|sp|P41244|VEG2_RAT_27:172 ; 113 gi|137823|sp|P20289|VEG1_RAT_27:172 ; 114 gi|8250627|emb|CAB93679.1|_26:176 ; 115 gi|1085207|pir||JC2556_26:187 ; 116 gi|1403310|emb|CAA67099.1|_22:175 ; 117 gi|1710096|sp|P06912|RETB_RABIT_24:192 ; 118 gi|230284|pdb|1RBP|_6:174 ; 119 gi|3121746|sp|O18874|ALL2_CANFA_28:175 ; 120 gi|544480|sp|P36992|AMBP_PLEPL_29:189 ; 121 gi|3041715|sp|P27485|RETB_PIG_24:192 ; 122 gi|2914422|pdb|1AQB|_6:174 ; 123 gi|89271|pir||A39486_24:192 ; 124 gi|5803139|ref|NP_006735.1|_22:190 ; 125 gi|88364|pir||A27786_6:174 ; 126 gi|730496|sp|P41263|RETB_CHICK_27:195 ; 127 gi|4558179|pdb|1QAB|E_3:171 ; 128 gi|112083|pir||A40464_21:171 ; 129 gi|3121745|sp|O18873|ALL1_CANFA_30:169 ; 130 gi|2136468|pir||I46257_24:192 ; 131 gi|6226255|sp|Q29147|TRIC_TRIVU_29:180 ; 132 gi|2317286|dbj|BAA21769.1|_49:206 ; 133 gi|125916|sp|P11944|LACB_MACGI_1:155 ; 134 gi|3122325|sp|Q29614|LACB_MACEU_19:174 ; 135 gi|3694896|gb|AAC62487.1|_16:162 ; 136 gi|1168469|sp|P09465|APHR_CRICR_10:165 ; 137 gi|4038489|emb|CAA12414.1|_10:165 ; 138 gi|448393|prf||1917182A_18:163 ; 139 gi|544253|sp|P35578|ESP4_LACVV_22:167 ; 140 gi|267585|sp|P24775|RET2_ONCMY_5:173 ; 141 gi|90181|pir||A31243_2:149 ; 142 gi|90284|pir||S10124_3:131 ; 143 gi|182093|gb|AAA35802.1|_28:157 ; 144 gi|267584|sp|P24774|RET1_ONCMY_5:173 ; 145 gi|6687453|emb|CAB64947.1|_21:189 ; 146 gi|6754514|ref|NP_034824.1|_31:173 ; 147 gi|7441753|pir||S51802_26:168 ; 148 gi|2497701|sp|Q28133|ALL2_BOVIN_17:170 ; 149 gi|1718160|sp|P53715|VEGP_PIG_28:171 ; 150 gi|5107505|pdb|1BJ7|_6:154 ; 151 gi|2443467|gb|AAC39166.1|_28:171 ; 152 gi|113824|sp|P06911|ERBP_RAT_23:171 ; 153 gi|576102|pdb|1EPA|B_2:149 ; 154 gi|204063|gb|AAA41127.1|_19:167 ; 155 gi|8777608|gb|AAF79021.1|_24:192 ; 156 gi|3913984|sp|Q29146|LACB_TRIVU_20:174 ; 157 gi|4557393|ref|NP_000597.1|_34:188 ; 158 gi|4097810|gb|AAD09351.1|_23:172 ; 159 gi|6679677|ref|NP_031973.1|_3:151 ; 160 gi|2136960|pir||I46688_33:188 ; 161 gi|5911439|gb|AAD55792.1|AF183407_1_9:154 ; 162 gi|89159|pir||A05309_1:128 ; 163 gi|3122574|sp|P81245|OBP_PIG_4:155 ; 164 gi|8567372|ref|NP_059499.1|_25:168 ; 165 gi|129095|sp|P06910|OLFA_RANPI_18:174 ; 166 gi|4504963|ref|NP_002288.1|_24:171 ; 167 gi|9181925|gb|AAF85708.1|AF276506_1_33:208 ; 168 gi|3694898|gb|AAC62488.1|_12:159 ; 169 gi|1835143|emb|CAA71867.1|_4:145 ; 170 gi|9506847|ref|NP_061998.1|_26:170 ; 171 gi|7303359|gb|AAF58418.1|_33:208 ; 172 gi|132408|sp|P06172|RETB_XENLA_26:194 ; 173 gi|4558087|pdb|1A3Y|B_4:147 ; 174 gi|199865|gb|AAA39762.1|_2:108 ; 175 gi|4558086|pdb|1A3Y|A_4:147 ; 176 gi|89098|pir||A05144_1:123 ; 177 gi|6900073|emb|CAB71321.1|_20:130 ; 178 gi|1146|emb|CAA33282.1|_7:128 ; 179 gi|6900069|emb|CAB71319.1|_20:129 ; 180 gi|102968|pir||S22400_26:178 ; 181 gi|124151|sp|P00305|ICYA_MANSE_9:162 ; 182 gi|124527|sp|Q00630|ICYB_MANSE_26:179 ; 183 gi|6900079|emb|CAB71324.1|_20:91 10 20 30 40 50 | | | | | 1 VEVTPIMTELDTQKVAGTWHTV.......AMAVSDVSL........LDAKSSPLKAYVEGLKPTP 2 -IVTQTMKGLDIQKVAGTWYSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 3 -IVTQTMKGLDIQKVAGTWYSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 4 -IVTQTMKGLDIQKVAGTWYSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 5 -IVTQTMKGLDIQKVAGTWYSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 6 -IVTQTMKGLDIQKVAGTWYSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 7 ---TQTMKGLDIQKVAGTWYSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 8 -IVTQTMKGLDIQKVAGTWYSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 9 -IVTQTMKGLDIQKVAGTWYSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 10 -IVTQTMKGLDIQKVAGTWYSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 11 -IVTQTMKGLDIQKVAGTWYSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 12 -IVTQTMKGLDIQKVAGTWYSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 13 -IVTQTMKGLDIQKVAGTWHSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 14 -IVTQTMKGLDIQKVAGTWHSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 15 -IVTQTMKGLDIQKVAGTWYSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 16 VEVTPIMTDLDTQKVAGTWHTV.......AMAVSDVSL........LDAKSSPLKAYVEGLKPTP 17 VEVTPIMTELDTQKVAGTWHTV.......AMAVSDVSL........LDAKSSPLKAYVEGLKPTP 18 --IPQTMQDLDLQEVAGKWHSV.......AMAASDISL........LDSESAPLRVYIEKLRPTP 19 ---PLTMDGLDLQKVAGMWHSM.......AMAASDISL........LDSETAPLRVYVQELRPTP 20 ------------QKVAGTWYSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 21 ---PLTMDGLDLQKVAGTWHSM.......AMAASDISL........LDSEYAPLRVYVQELRPTP 22 -VVPRTMEDLDLQKVAGTWHSM.......AMAASDISL........LDSETAPLRVYIQELRPTP 23 --IPQTMQDLDLQEVAGKWHSV.......AMAASDISL........LDSEEAPLRVYIEKLRPTP 24 --IPQTMQDLDLQEVAGKWHSV.......AMAASDISL........LDSEEAPLRVYIEKLRPTP 25 --LPPTMEDLDIRQVAGTWHSM.......AMAASDISL........LDSETAPLRVYVQELRPTP 26 --------GLDLQKVAGTWHSM.......AMAASDISL........LDSETAPLRVYVQELRPTP 27 --LPPTMEDLDIRQVAGTWHSM.......AMAASDISL........LDSETAPLRVYVQELRPTP 28 -VIPRTMEDLDLQKVAGTWHSM.......AMAASDISL........LDSETAPLRVYIQELRPTP 29 --------GLDLQKVAGMWHSM.......AMAASDISL........LDSETAPLRVYVQELRPTP 30 ---PLTMDGLDLQKVAGMWHSM.......AMAASDISL........LDSETAPLRVYVQ-LRPTP 31 --------DLDIRQVAGMWHSM.......AMAASDISL........LDSETAPLRVYVQELRPTP 32 --------DLDIRQVAGTWHSM.......AMAASDISL........LDSETAPLRVYVQELRPTP 33 -VIPRTMEDLDLQKVAGTWHSM.......AMAASDISL........LDSETAPLRVYIQELRPTP 34 -DIPQTMQDLDLQEVAGRWHSV.......AMVASDISL........LDSESAPLRVYVEELRPTP 35 --------GLDLQKVAGMWHSM.......AMAASDISL........LDSETAPLRVYVQELRPTP 36 --QVSLQPNFQQDKFLGRWFTS.......GLASNSSWF........RE-KKNVLSMCMSVVAPTA 37 ------RGNLDVDKLNGDWFSI.......VVASDKREK........IE-ENGSMRVFVQHIDVL- 38 ------RGNLDVDKLNGDWFSI.......VVASDKREK........IE-ENGSMRVFVQHIDVL- 39 -DIPQTMQDLDLQEVAGRWHSV.......AMVASDISL........LDSESVPLRVYVEELRPTP 40 --QVSLQPNFQQDKFLGRWFTS.......GLASNSSWF........RE-KKKVLSMCVSVVAPSA 41 --QVSRQPNFQQDKFLGRWFTS.......GLASNSSWF........RE-KKNALSMCISVVAPSA 42 -AQVSVQPNFQPDKFLGRWFSA.......GLASNSSWL........QE-KKAALSMCKSVVAPAT 43 -----VQPNFQQDKFLGRWYSA.......GLASNSSWF........RE-KKELLFMCQTVVAPST 44 ----SKGQNLNVEKINGEWFSI.......LLASDKREK........IE-EHGSMRVFVEHIHVL- 45 --PVSVQPEFQQDKFLGRWFTA.......GLASNSSWF........RE-KKAALSMCRSTVAPTE 46 VEVTPIMTELDTQKVAGTWHTV.......AMAVSDVSL........LDAKSSPLKAYVEGLKPTP 47 -AQVSVQPNFQQDKFLGRWFSA.......GLASNSSWL........RE-KKAALSMCKSVVAPAT 48 -AQVSVQPNFQPDKFLGRWFSA.......GLASNSSWL........QE-KKAALSMCKSVVAPAA 49 -AQVSVQPNFQPDKFLGRWFSA.......GLASNSSWL........QE-KKAALSMCKSVVAPAA 50 MDIPQTKQDLELPKLAGTWHSM.......AMATNNISL........MATLKAPLRVHITSLLPTP 51 --ASSTRGNLDVDKLNGDWFSI.......VVASNKREK........IE-ENGSMRVFMQHIDVL- 52 ------RGNLDVDKLNGDWFSI.......VMASDKREK........IE-ENGSMRVFMQHIDVL- 53 MDIPQTKQDLELPKLAGTWHSM.......AMATNNISL........MATLKAPLRVHITSLLPTP 54 --EVQVQPDFQKEKVLGKWYGI.......GLASNSNWF........KD-RKSHMKMCTTIITPTA 55 ----ALQPNFEEDKFLGRWFTS.......GLASNSSWF........LE-KKKVLSMCKSVVAPAA 56 --EVQVQPDFQKEKVLGKWYGI.......GLASNSNWF........KD-RKSHMKMCTTIITPTA 57 --ASSTRGNLDVDKLNGDWFSI.......VVASDKREK........IE-ENGSMRVFMQHIDVL- 58 -----LQPNFEEDKFLGRWFTS.......GLASNSSWF........LE-KRKVLSMCKSEVAPAA 59 --ASSTRGNLDVDKLNGDWFSI.......VVASDKREK........IE-ENASMRVFMQHIDVL- 60 LSKVPLQQNFQDNQFQGKWYVV.......GLAGNAILR........ED--KDPQKMYATIYELKE 61 ------RGNLDVDKLNGDWFSI.......VMASDKREK........IE-ENGSMRVFVQHIDVL- 62 LSKVPLQQNFQDNQFQGKWYVV.......GLAGNAILR........ED--KDPQKMYATIYELKE 63 LSKVPLQQNFQDNQFQGKWYVV.......GLAGNAILR........ED--KDPQKMYATIYELKE 64 LSKVPLQQNFQDNQFQGKWYVV.......GLAGNAILR........ED--KDPQKMYATIYELKE 65 LSKVPLQQNFQDNQFQGKWYVV.......GLAGNAILR........ED--KDPQKMYATIYELKE 66 --ASSTRGNLDVAKLNGDWFSI.......VVASNKREK........IE-ENGSMRVFMQHIDVL- 67 LSKVPLQQNFQDNQFQGKWYVV.......GLAGNAILR........ED--KDPQKMYATIYELKE 68 --ASSTSGNLDVAKLNGDWFSI.......VVASNKREK........IE-ENGSMRVFMQHIDVL- 69 --ASSTTGNRDVDKLNGDWFSI.......VVASDKREK........IE-ENGSMRVFVQHIRVL- 70 --ASSVRGNLDVDKLNGDWFSI.......VLASDKREK........IE-ENGSMRVFMQHIDVL- 71 --DVPIQPDFQEDKILGKWYGI.......GLASNSNWF........QS-KKQQLKMCTTVITPTA 72 --ASSTGRNFNVEKINGEWHTI.......ILASDKREK........IE-DNGNFRLFLEQIHVL- 73 ---SSERQNFNVEKINGKWFSI.......LLASDKREK........IE-EHGTMRVFVEHIDVL- 74 --QPSLQPNFQQDKFLGRWFTS.......GLASNSSWF........RE-KKKVLSMCTSVVAPTA 75 LSKVPLQQNFQDNQFQGKWYVV.......GLAGNAILR........ED--KDPQKMYATIYELKE 76 --ASSTGRNFNVEKINGEWHTI.......ILASDKREK........IE-DNGNFRLFLEQIHVL- 77 -DIPQTKQDLELPKLAGTWHSM.......AMATNNISL........MATLKAPLRVHITSLLPTP 78 --ASSTGRNFNVEKINGEWHTI.......ILASDKREK........IE-DNGNFRLFLEQIHVL- 79 --ASSTGRNFNVEKINGEWHTI.......ILASDKREK........IE-DNGNFRLFLEQIHVL- 80 --ASSTGRNFNVEKINGEWHTI.......ILASDKREK........IE-DNGNFRLFLEQIHVL- 81 --ASSTGRNFNVEKINGEWHTI.......ILASDKREK........IE-DNGNFRLFLEQIHVL- 82 --ASSTGRNFNVEKINGEWHTI.......ILASDKREK........IE-DNGNFRLFLEQIHVL- 83 ------RGNVDVDKLNGDWFSI.......VMASDKREK........IE-ENGSMRVFVQHIDVL- 84 LSKVPLQQNFQDNQFQGKWYVV.......GLAGNAILR........ED--KDPQKMYATIYEEKE 85 -NSPQTMQDVELPKLAGTWHSM.......AMAASDFSL........LETKEAPLRIYISSLQPTP 86 -----ERGNLDVDKLNGDWFSI.......VVASNKREK........IE-ENGSMRVFMQHIDVL- 87 ---ASLQPNFQEDKFLGRWFTS.......GLASNSSWF........LE-KKKVLSMCKSLVAPAP 88 --ASSTGRNFNVEKINGEWHTI.......ILAFDKREK........IE-DNGNFRLFLEQIHVL- 89 -----VQPNFQQDKFLGRWYSA.......GLASNSSWF........RE-KKAVLYMCKTVVAPST 90 -----VQPNFQQDKFLGRWYSA.......GLASNSSWF........RE-KKELLFMCQTVVAPST 91 -------------KINGEWHTI.......ILASDKREK........IE-DNGNFRLFLEQIHVL- 92 -DIPQTMQDLDLQEVAGRWHSV.......AMVASDISL........LDSEEAPLRVYVEELRPTP 93 ----------DRSEIAGKWYVV.......ALASNTEFF........LR-EKDKMKMAMARISFLG 94 IIVTQTMKGLDIQKVAGTWHSL.......AMAASDISL........LDAQSAPLRVYVEELKPTP 95 -ISVPLQPGFWTERFQGRWFVV.......GLAANAVQK........ER--QSRFTMYSTIYELQE 96 ----------DRSEVAGKWYIV.......ALASNTDFF........LR-EKGKMKMVMARISSLG 97 --SSSMERNFNVEQISGYWFSI.......AEASYEREK........IE-EHGSMRAFVENITVL- 98 -ISVPLQPGFWTERFQGRWFVV.......GLAGNAVQK........ER--QSRFTMYSTIYELQE 99 ----------DRSEVAGKWYIV.......ALASNTDFF........LR-EKGKMKMVMARISFLG 100 -----TRGNLDVAKLNGDWFSI.......VVASNKREK........IE-ENGSMKVFMQHIDVL- 101 ----------DRSEVAGKWYIV.......ALASNTDFF........LR-EKGKMKMVMARISFLG 102 ----------DSSEVAGKWYIV.......ALASNTDSF........LR-EKGKMKMVMARISFLG 103 ---------LEEEDITGTWYVK.......AMVVDKDFP........ED--RRPRKVSPVKVTALG 104 VSSFRVKENFDKARFAGTWYAM.......AKKDPEGLF........LQ------DNIVAEFSVDE 105 ----------EEEDITGTWYVK.......AMVVDKDFP........ED--RRPRKVSPVKVTALG 106 VSSFRVKENFDKARFAGTWYAM.......AKKDPEGLF........LQ------DNIVAEFSVDE 107 --------NFDISKISGEWYSI.......FLASDVKEK........IE-ENGSMRVFVDVIRALD 108 ----------EEEDITGTWYVK.......AMVVDKDFP........ED--RRPRKVSPVKVTALG 109 -------RNFDISKISGEWYSI.......FLASDVKEK........IE-ENGSMRVFVDVIRALD 110 VSSFRVKENFDKARFAGTWYAM.......AKKDPEGLF........LQ------DNIVAEFSVDE 111 -DNIQIQENFDLQRIYGKWYDI.......AIGSTCKWL........KH-HKEKFNMGTLELSDGE 112 -----------NQDVSGTWYLK.......AAAWDKEIP........DK-KFGSVSVTPMKIKTLE 113 -----------NQDVSGTWYLK.......AAAWDKEIP........DK-KFGSVSVTPMKIKTLE 114 ------TSNFDASKIAGEWYSI.......LLASDAKEN........IE-ENGSMRVFVEHIRVLD 115 -PLFPIQDNFDLTKFMGKWHDI.......AIGSTCPWM........QRHKGDAAIGTLELQASGT 116 ---GPGDPNFDEKLVKGKWFSV.......ALASNEPKF........IA-KDTDMKFFIHKIQVT- 117 VSSFRVKENFDKARFAGTWYAM.......AKKDPEGLF........LQ------DNIVAEFSVDE 118 VSSFRVKENFDKARFSGTWYAM.......AKKDPEGLF........LQ------DNIVAEFSVDE 119 ---------GGLEELSGRWHSV.......ALASNKSDL........IK-PWGHFRVFIHSMSAK- 120 -PLYPTQENFDLTRFVGTWHDV.......ALTSSCPHM........QR-NRADAAIGKLVLEKDT 121 VSSFRVKENFDKARFSGTWYAM.......AKKDPEGLF........LQ------DNIVAEFSVDE 122 VSSFRVKENFDKARFSGTWYAM.......AKKDPEGLF........LQ------DNIVAEFSVDE 123 VSSFRVKENFDKARFSGTWYAM.......AKKDPEGLF........LQ------DNIVAEFSVDE 124 VSSFRVKENFDKARFSGTWYAM.......AKKDPEGLF........LQ------DNIVAEFSVDE 125 VSSFRVKENFDKARFSGTWYAM.......AKKDPEGLF........LQ------DNIVAEFSVDE 126 VSSFKVKENFDKNRYSGTWYAM.......AKKDPEGLF........LQ------DNVVAQFTVDE 127 VSSFRVKENFDKARFSGTWYAM.......AKKDPEGLF........LQ------DNIVAEFSVDE 128 -----EAPPDDQEDFSGKWYTK.......ATVCDRNHT........DG--KRPMKVFPMTVTALE 129 -------------AVSGKWYLK.......AMTADQEVP........EK----PDSVTPMILKAQK 130 VSSFRVKENFDKARFSGTWYAM.......AKKDPEGLF........LQ------DNIVAEFSVDE 131 -----DEKERKWEQLSRHWHTV.......VLASSDRSL........IE-EEGPFRNFIQNITVE- 132 ----QCSPTFNKTSSWGAGTAR.......VLASNSSWF........RE-KKAVLYMCKTVVAPST 133 VENIRSKNDLGVEKFVGSWYLR.......EAAKTMEFS........IP----LFDMDIKEVNLTP 134 VENIRSKNDLGVEKFVGSWYLR.......EAAKTMEFS........IP----LFDMDIKEVNLTP 135 --DIPVVPNFDPQKTVGKWHPI.......GMASKLPELtp......YEQKISPMDHIVEVI---- 136 --VFSLAHAQDFAELQGKWYTI.......VIAADNLEK........IE-EGGPLRFYFRHIDCYK 137 --VFSLAHAQDFAELQGKWYTI.......VIAADNLEK........IE-EGGPLRFYFRHIDCYK 138 --DIPVVPNFDAQKTVGKWHPI.......GMASKLPEVpe......YEQKISPMDHMVELT---- 139 --DIPVVPNFDAQKTVGKWHPI.......GMASKLPEVpe......YEQKISPMDHMVELT---- 140 VSNIQVMQNFDRSRYTGRWYAV.......AKKDPVGLF........LL------DNVVAQFSVDG 141 ----------DFAELQGKWYTI.......VIAADNLEK........IE-EGGPLRFYFRHIDCYK 142 ----------------------.......------REK........IE-DNGNFRLFLEQIHVL- 143 ----------------------.......---------........LELPKAPLRVHITSLLPTP 144 VSNIQVMQNFDRSRYTGRWYAV.......AKKDPVGLF........LL------DNVVAQFSVDE 145 VSNFAVQQDFNRTRYQGTWYAV.......AKKDPVGLF........LL------DNIVANFKVEE 146 ---------FNNGNFSGKWFLK.......ALVSEDDIP........IN------KVSPMLILVLN 147 ---------FNNGNFSGKWFLK.......ALVSEDDIP........IN------KVSPMLILVLN 148 ---QETPAEIDPSKIPGEWRII.......YAAADNKDK........IV-EGGPLRNYYRRIECIN 149 ----------PLQDLLGRWYLK.......AMTSDPEIP........---GKKPESVTPLILKALE 150 --------EIDPSKIPGEWRII.......YAAADNKDK........IV-EGGPLRNYYRRIECIN 151 ----------PLQDLLGRWYLK.......AMTSDPEIP........---GKKPESVTPLILKALE 152 ----AVVKDFDISKFLGFWYEI.......AFASKMGTPg.......LAHKEEKMGAMVVELK--- 153 -----VVKDFDISKFLGFWYEI.......AFASKMGTPg.......LAHKEEKMGAMVVELK--- 154 ----AVVKDFDISKFLGFWYEI.......AFASKMGTPg.......LAHKEEKMGAMVVELK--- 155 VANIQVMQNFDKTRYAGTWYAV.......GKKDPEGLF........LI------DNIVAQFTIHE 156 -ENIHSKEELVVEKLIGPWYRV.......EEAKAMEFS........IP----LFDMNIKEVNRTP 157 -STIQPKANFDAQQFAGTWLLV.......AVGSACRFL........QE-QGHRAEATTLHVAPQ- 158 ----AVVKDFDVNKFLGFWYEI.......ALASKMGAYg.......LAHKEEKMGAMVVELK--- 159 -----VVKDFDVNKFLGFWYEI.......ALASKMGAYg.......LAHKEEKMGAMVVELK--- 160 ISAIQPKANFDAQQFAGTWLLA.......AVGSACHFL........QE-QGHRAEATALHVAPQ- 161 -----------PSEVDGKWHSL.......YIAADNKSK........VS-EGGPLRVYVKHLECSD 162 VEVTPIMTELDTQKVAGTWHTV.......AMAVSBVSL........LBAKSSPLKAYVZGLKPTP 163 ------QPEQDPFELSGKWITS.......YIGSSDLEK........IG-ENAPFQVFMRSIEFDD 164 -------------KIDGPWQTI.......YLAASTMEK........IN-EGSPLRTYFRHILCGR 165 -DLPPVMKGLEENKVTGVWYGI.......AAASNCKQF........LQMKSDNMPAPVNIYSLN- 166 -------SDEEIQDVSGTWYLK.......AMTVDREFP........---EMNLESVTPMTLTTLE 167 CPNYPSMPKFNMSRVLGHWYEVersfylpEIASGCTTFqfe.....10geqSKFSNSKLAVAIKN 168 --DIPVVANFDTPKTVGKWHPI.......GMASKLPELtp......YEQKISPMDHIVEVT---- 169 ----------------GPWKTV.......AIAADRVDK........IE-RGGELRIYCRSLTCEK 170 ------------KKIEGNWRTV.......YLAASSVEK........IN-EGSPLRTYFRRIECGK 171 CPNYPSMPKFNMSRVLGHWYEVersfylpEIASGCTTFqfe.....10geqSKFSNFKLAVAIKN 172 VDNFEVMKDFNKERYAGVWYAV.......AKKDPEGLF........LL------DNIAANFKIED 173 --------------LSGKWITS.......YIGSSDLEK........IG-ENAPFQVFMRSIEFDD 174 ----------------------.......---------........------------------- 175 --------------LSGKWITS.......YIGSSDLEK........IG-ENAPFQVFMRSIEFDD 176 VSVIRTMEDLDIQRVAGTWHSV.......AMAASDISL........LDTEEAPLRVNVEELRPTP 177 ---------LEEEDITGTWYVK.......AMVVDKDFP........ED--RRPRKVSPVKVTALG 178 ----------------------.......---------........-------FDMDIKEVNLTP 179 ---------LEEEDITGTWYVK.......AMVVDKDFP........ED--RRPRKVSPVKVTALG 180 CPEVKPVDDFDLSAFAGAWHEI.......A-----KLP........LE-NENEGKCTVAEYKYD- 181 CPDVKPVNDFDLSAFAGAWHEI.......A-----KLP........LE-NENQGKCTIAEYKYD- 182 CPDVKPVDDFDLSAFAGAWHEI.......A-----KLP........LE-NENQGKCTIAEYKYD- 183 ---------LEEEDITGTWYVK.......AMVVDKDFP........ED--RRPRKVSPVKVTALG 60 70 80 90 | | | | 1 EGD.LEIL........LQKRENDKCAQEVLLAKKTDIP.....AVFKI.NALDEN........QL 2 EGD.LEIL........LQKWENDECAQKKIIAEKTKIP.....AVFKL.DAINEN........KV 3 EGD.LEIL........LQKWENGECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 4 EGD.LEIL........LQKWENDECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 5 EGD.LEIL........LQKWENGECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 6 EGD.LEIL........LQKWENGECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 7 EGD.LEIL........LQKWENDECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 8 EGN.LEIL........LQKWENGECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 9 EGD.LEIL........LQKWENGECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 10 EGN.LEIL........LQKWENGECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 11 EGD.LEIL........LQKWENGECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 12 EGN.LEIL........LQKWENGECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 13 EGN.LEIL........LQKWENGECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 14 EGN.LEIL........LQKWENGECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 15 EGD.LEIL........LQKWENDECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 16 EGD.LEIL........LQKRENDKCAQEVLLAKKTDIP.....AVFKI.NALDEN........QL 17 EGD.LEIL........LQKRENDKCAQEVLLAKKTDIP.....AVFKI.NALDEN........QL 18 EDN.LEII........LREGENKGCAEKKIFAEKTESP.....AEFKI.NYLDED........TV 19 RDN.LEII........LRKWEDNRCVEKKVLAEKTECA.....AKFNI.NYLDEN........EL 20 EGD.LEIL........LQKWENDECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 21 RDN.LEII........LRKWEQKRCVQKKILAQKTELP.....AEFKI.SYLDEN........EL 22 QDN.LEIV........LRKWEDGRCAEQKVLAEKTEVP.....AEFKI.NYVEEN........QI 23 EDN.LEII........LREGENKGCAEKKIFAEKTESP.....AEFKI.NYLDED........TV 24 EDN.LEII........LREGENKGCAEKKIFAEKTQSP.....AQFKI.NALDED........TV 25 RDN.LEII........LRKRENHACIEGNIMAQRTEDP.....AVFMV.DYQGEK........KI 26 RDN.LEII........LRKWEHGRCVQKKVWAEKTELL.....AEFKI.SYLDEN........EL 27 RDN.LEII........LRKRENHACIEGNIMAQRTEDP.....AVFMV.DYQGEK........KI 28 QDN.LEIV........LRKWEDNRCVEKKVFAEKTELA.....AXFSI.NYVEEN........QI 29 RDN.LEII........LRKWEDNRCVEKKVLAEKTECA.....AKFNI.NYLDEN........EL 30 RDN.LEII........LRKWEDNRCVEKKVLAEKTECA.....AKFNI.NYLDEN........EL 31 QDN.LEII........LRKRENHACIEGNIMAQRTEDP.....AVFTV.DYQGEK........KI 32 QDN.LEII........LRKRENHACIEGNIMAQRTEDP.....AVFMV.DYQGEK........KI 33 QDN.LEIV........LRKWEDNRCVEKKVFAEKTELA.....AYFSI.NYVEEN........QI 34 EGN.LEII........LREGANHVCVERNIVAQKTEDP.....AVFTV.NYQGER........KI 35 RDN.LEII........LRKWEDNRCVEKKVLAEKTECV.....AKFNI.NYLDEN........EL 36 DGG.LNLT........STFLRKDQCETRTLLLRPAGTP.....GCYSY.TSPHWGsth.....DV 37 ENS.LGFT........FRIKENGVCTEFSLVADKTAKD.....GEYFV.EYDGEN........TF 38 ENS.LGFT........FRIKENGVCTEFSLVADKTAKD.....GEYFV.EYDGEN........TF 39 EGN.LEII........LREGANHACVERNIVAQKTEDP.....AVFTV.NYQGER........KI 40 DGG.LNLT........STFLRKEQCETRTLLLRPAGTP.....GCYSY.TSPHWGsth.....DV 41 EGG.LNLT........TTFLRKDQCETRTLLLRPAETP.....GCYSY.TSPHWGsth.....DV 42 DGG.LNLT........STFLRKNQCETRTMLLQPGESL.....GSYSY.GSPHWGsty.....SV 43 EGG.LNLT........STFLRKNQCETKVMVLQPAGVP.....GQYTY.NSPHWGsfh.....SL 44 ENS.LAFK........FHTVIDGECSEIFLVADKTEKA.....GEYSV.MYDGFN........TF 45 EGA.LNIT........STFLRKNQCETRTLLLQPAGRP.....GRYTY.TSPHWGsty.....SV 46 EGD.LEIL........LCKRENDKCAQEVLLAKKTDIP.....AVFKI.NALDEN........QL 47 DGG.LNLT........STFLRKNQCETRTMLLQPAGSL.....GSYSY.RSPHWGsty.....SV 48 DGG.FNLT........STFLRKNQCETRTMLLQPGDSL.....GSYSY.RSPHWGsty.....SV 49 DGG.FNLT........STFLRKNQCETRTMLLQPGDSL.....GSYSY.RSPHWGsty.....SV 50 EDN.LEIV........LHRWENNSCVEKKVLGEKTENP.....KKFKI.NYTVAN........EA 51 ENS.LGFK........FRIKENGECRELYLVAYKTPED.....GEYFV.EYDGGN........TF 52 ENS.LGFK........FCIKVNGECRELYLVAYKTPKE.....GEYFV.EYDGGN........TF 53 EDN.LEIV........LHRWENNSCVEKKVLGEKTENP.....KKFKI.NYTVAN........EA 54 DGN.LEVT........ATYPKMDRCETKSMTYFKTEQL.....GGFRA.KSPRYGseh.....DM 55 DGG.LNLT........STFLRKDQCETRTLLLRPAGPP.....GCYSY.TSPHWSsth.....EV 56 DGN.VEVT........ATYPKMDRCETKSMTYFKTEQL.....GRFRA.KSPRYGseh.....DM 57 ENS.LGFK........FRIKENGECRELYLVAYKTPED.....GEYFV.EYDGGN........TF 58 DGG.LNVT........STFLRKDQCETRTLLLRPAGPP.....GCYSY.TSPHWSsth.....EV 59 ENS.LGFK........FRIKENGECRELYLVAYKTPED.....GEYFV.EYDGGN........TF 60 DKS.YNVT........SVLFRKKKCDYWIRTFVPGCQP.....GEFTL.GNIKSYpgltsy..LV 61 ENS.LGFK........FHIKVNGKCRELYLVAYKTPKD.....GEYFV.EYDGGN........TF 62 DKS.YNVT........SVLFRKKKCDYWIRTFVPGCQP.....GEFTL.GNIKSYpgltsy..LV 63 DKS.YNVT........SVLFRKKKCDYWIRTFVPGCQP.....GEFTL.GNIKSYpgltsy..LV 64 DKS.YNVT........SVLFRKKKCDYWIRTFVPGCQP.....GEFTL.GNIKSYpgltsy..LV 65 DKS.YNVT........SVLFRKKKCDYWIRTFVPGCQP.....GEFTL.GNIKSYpgltsy..LV 66 ENS.LGFK........FRIKENGECRELYLVAYKTPED.....GEYFV.EYDGGN........TF 67 DKS.YNVT........SVLFRKKKCDYWIRTFVPGCQP.....GEFTL.GNIKSYpgltsy..LV 68 ENS.LGFK........FRIKENGECRELYLVAYKTPED.....GEYFV.EYDGGN........TF 69 ENS.LAFK........FRIKENGVCTEFSLVAYKTPKD.....GEYFV.EYDGGN........TF 70 ENS.LGFK........FHIKKNGECREVYLVAYKTPKD.....GEYFV.EHDGGN........TF 71 DGN.LDVV........ATFPKLDRCEKKSMTYIKTEQP.....GRFLS.KSPRYGsdh.....VI 72 ENS.LVLK........FHTVRDEECSELSMVADKTEKA.....GEYSV.TYDGFN........TF 73 ENS.LAFK........FHTVIDEECTEIYLVADKTEKA.....GEYSV.TYDGFN........TF 74 DGG.FNLT........STFLRKDQCETRTLLLQPAGPP.....GCYSY.TSPHWGmvh.....EV 75 DKS.YNVT........SVLFRKKKCDYWIRTFVPGCQP.....GEFTL.GNIKSYpgltsy..LV 76 ENS.LVLK........FHTVRDEECSELSMVADKTEKA.....GEYSV.TYDGFN........TF 77 EDN.LEIV........LHRWENNSCVEKKVLGEKTGNP.....KKFKI.NYTVAN........EA 78 ENS.LVLK........FHTVRDEECSELSMVADKTEKA.....GEYSV.TYDGFN........TF 79 ENS.LVLK........FHTVRDEECSELSMVADKTEKA.....GEYSV.TYDGFN........TF 80 ENS.LVLK........FHTVRDEECSELSMVADKTEKA.....GEYSV.TYDGFN........TF 81 EKS.LVLK........FHTVRDEECSELSMVADKTEKA.....GEYSV.TYDGFN........TF 82 EKS.LVLK........FHTVRDEECSELSMVADKTEKA.....GEYSV.TYDGFN........TF 83 ENS.LGFK........FRIKVNGKCRELYLVAYKTPKD.....GEYFV.EYDGGN........TF 84 DAS.YNVT........SVLFRKKKCDYAIRTFVPGCQP.....GEFTL.GNIKSYpgltsy..LV 85 EGN.LEIVlrrwsqkqSPFRDSNQCIEEKIIAEKTENP.....IEFKI.NYLDEN........RI 86 ENS.LGFK........LCIKENGECRKLYSVAYKTPKI.....GEYFL.EYDGGN........TF 87 DGG.FNLT........STFLRKDQCVTRTLMLRPAGPP.....GCYSY.TSPHGGsnl.....EV 88 ENS.LVLK........FHTVRDEECSELSMVADKTEKA.....GEYSV.TYDGFN........TF 89 EGG.LNLT........STFLRKNQCETKIMVLQPAGAP.....GHYTY.SSPHSGsih.....SV 90 EGG.LNLT........STFLRKNQCETKVMVLQPAGVP.....GQYTY.NSPHWQlp......LP 91 ENS.LVLK........FHTVRDEECSELSMVADKTEKA.....GEYSV.TYDGFN........TF 92 EGN.LEII........LREGANHACVERNIVAQKTESP.....AEFKT.EDSAVF........TV 93 EDE.LKVS........YAVPKPNGCRKWETTFKKTSDD.....GEVYY.SEEAKK........KV 94 EGN.LEIL........LQKWENGECAQKKIIAEKTKIP.....AVFKI.DALNEN........KV 95 DNS.YNVT........SILVRGQGCRYWIRTFVPSSRP.....GQFTL.GNIHSYpqiqsy..DV 96 EDE.LEVS........YAAPSPKGCRKWETTFKKTSDD.....GEVYY.SEEAEK........TV 97 ENS.LVFK........FHLIVNEECTEMTAIGEQTEKA.....GIYYM.NYDGFN........TF 98 DNS.YNVT........SILVRGQGCRYWIRTFVPSSRP.....GQFTL.GNIHSYpqiqsy..DV 99 EDE.LEVS........YAAPSPKGCRKWETTFKKTSDD.....GEVYY.SEEAEK........TV 100 ENS.LGFK........FRIKENGECRELYLVAYKTPED.....GEYFV.EYDGGN........TF 101 EDE.LEVS........YAAPSPKGCRKWETTFKKTSDD.....GELYY.SEEAEK........TV 102 EDE.LEVS........YAAPSPKGCRKWETTFKKTSDD.....GELYY.SEEAEK........TV 103 GGK.LEAT........FTFMREDRCIQKKILMRKTEEP.....GKYSA.-YGGRK........LM 104 NGH.MSATakgrv...RLLNNWDVCADMVGTFTDTEDP.....AKFKM.KYWGVAsflqkgndDH 105 GGN.LEAT........FTFMREDRCIQKKILMRKTEEP.....GKFSA.-YGGRK........LI 106 NGQ.MSATakgrv...RLLNNWDVCADMVGTFTDTEDP.....AKFKM.KYWGVAsflqkgndDH 107 NSS.LYAE........YQTKVNGECTEFPMVFDKTEED.....GVYSL.NYDGYN........VF 108 GGN.LEAT........FTFMREDRCIQKKILMRKTEEP.....GKYSA.-YGGRK........LI 109 NSS.LYAE........YQTKVNGECTEFPMVFDKTEED.....GVYSL.NYDGYN........VF 110 NGH.MSATakgrv...RLLNNWDVCADMVGTFTDTEDP.....AKFKM.KYWGVAsflqkgndDH 111 TDGeVRIV........NTRMRHGTCSQIVGSYQKTETP.....GKFDY.FNARWGtti.....QN 112 GGN.LQVK........FTVLISGRCQEMSTVLEKTDEP.....GKYTA.-YSGKQ........VV 113 GGN.LQVK........FTVLIAGRCKEMSTVLEKTDEP.....AKYTA.-YSGKQ........VL 114 NSS.LAFK........FQRKVNGECTDFYAVCDKVGD-.....GVYTV.AYYGEN........KF 115 EDK.VSMT........RSMKKHGKCEQISGDYELTATP.....GRLTY.HIAKWGadv.....DA 116 PES.LQFH........FHRKVRGMCVPTMMTAHKTKKK.....FQYTV.NHSGHK........TI 117 NGH.MSATakgrv...RLLNNWDVCADMVGTFTDTEDP.....AKFKM.KYWGVAsflqrgndDH 118 TGQ.MSATakgrv...RLLNNWDVCADMVGTFTDTEDP.....AKFKM.KYWGVAsflqkgndDH 119 DGN.LHGD........ILIPQDGQCEKVSLTAFKTATS.....NKFDL.EYWGHN........DL 120 GNK.LKVT........RTRLRHGTCVEMSGEYELTSTP.....GRIFY.HIDRWDadv.....DA 121 NGH.MSATakgrv...RLLNNWDVCADMVGTFTDTEDP.....AKFKM.KYWGVAsflqkgndDH 122 NGH.MSATakgrv...RLLNNWDVCADMVGTFTDTEDP.....AKFKM.KYWGVAsflqkgndDH 123 NGH.MSATakgrv...RLLNNWDVCADMVGTFTDTEDP.....AKFKM.KYWGVAsflqkgndDH 124 TGQ.MSATakgrv...RLLNNWDVCADMVGTFTDTEDP.....AKFKM.KYWGVAsflqkgndDH 125 TGQ.MSATakgrv...RLLNNWDVCADMVGTFTDTEDP.....AKFKM.KYWGVAsflqkgndDH 126 NGQ.MSATakgrv...RLFNNWDVCADMIGSFTDTEDP.....AKFKM.KYWGVAsflqkgndDH 127 TGQ.MSATakgrv...RLLNNWDVCADMVGTFTDTEDP.....AKFKM.KYWGVAsflqkgndDH 128 GGD.LEVR........ITFRGKGHCHLRRITMHKTDEP.....GKYTT.-FKGKK........TF 129 GGN.LEAK........ITMLTNGQCQNITVVLHKTSEP.....GKYTA.-YEGQR........VV 130 YGQ.MSATakgrv...RLLNNWDVCADMVGTFTDTEDP.....AKFKM.KYWGVAsflqkgndDH 131 SGN.LNGF........FLTRKNGQCIPLYLTAFKTEEA.....RQFKL.NYYGTN........DV 132 EGG.LNLT........STFLRKNQCETKIMVLQPAGAP.....GHYTY.SSPHSGsih.....SV 133 EGN.LELV........LLEKT-DRCVEKKLLLKKTKKP.....TEFEI.YISSESsy......TF 134 EGN.LELV........LLEKA-DRCVEKKLLLKKTQKP.....TEFEI.YISSESasy.....TF 135 DGD.MKLT........ANYMSDGVSKEATAMLKHTDKP.....GVFKF.---TDG........EV 136 NCSeMEIT........FYVITNNQCSKTTVIGYLKGN-.....GTYQT.QFEGNN........IF 137 NCSeMEIT........FYVITNNQCSKTTVIGYLKGN-.....GTYQT.QFEGNN........IF 138 DGD.MKLT........ANYMD-GVCKEATAMLKHTDKP.....GVFKF.---TGG........EI 139 DGD.MKLT........ANYMD-GVCKEATAMLKHTDKP.....GVFKF.---TGG........EI 140 SGK.VTATaqgrv...IILNNWEMCANMFGTFEDTPDP.....AKFKM.RYWGAAaylqsgndDH 141 NCSeMEIT........FYVITNNQCSKTTVIGYLKGN-.....GTYQT.QFEGNN........IF 142 EKS.LVLK........FHTVRDEECSELSMVADKTEKA.....GEYSV.TYDGFN........TF 143 EDN.LEIV........LHRWENNSCVEKKVLGEKTENP.....KKFKI.NYTVAN........EA 144 SGK.VTATahgrv...IILNNWEMCANMFGTFEDTPDP.....AKFKM.RYWGAAsylqtgndDH 145 DGT.MTATaigrv...IILNNWEMCANMFGTFEDTEDP.....AKFKM.KYWGAAaylqtgydDH 146 NGD.IELS........ITHMIYDQCLEVTTILEKTDVP.....GQYLA.-FEGKT........HL 147 NGD.IELS........ITHMIYDQCLEVTTILEKTDVP.....GQYLA.-FEGKT........HL 148 DCEsLSIT........FYLKDQGTCLLLTEVAKRQEG-.....YVYVL.EFYGTN........TL 149 GGD.LEAQ........ITFLIDGQCQDVTLVLKKTNQP.....FTFTA.-YDGKR........VV 150 DCEsLSIT........FYLKDQGTCLLLTEVAKRQEG-.....YVYVL.EFYGTN........TL 151 GGD.LEAQ........ITFLIDGQCQDVTLVLKKTNQP.....FTFTA.-YDGKR........VV 152 ENL.LALT........TTYYSEDHCVLEKVTATEGDGP.....AKFQV.TRLSGKk.......EV 153 ENL.LALT........TTYYSEDHCVLEKVTATEGDGP.....AKFQV.TRLSGKk.......EV 154 ENL.LALT........TTYYSEDHCVLEKVTATEGDGP.....AKFQV.TRLSGKk.......EV 155 DGA.MTATakgrv...IILNNWEMCADMMATFETTPDP.....AKFRM.RYWGAAsylqtgndDH 156 EGN.LELI........VLEQT-DSCVEKKFLLKKTEKP.....AEFEI.YIPSESasy.....TL 157 GTA.MAVS........TFRKLDGICWQVRQLYGDTGVL.....GRFLL.QARGARgav.....HV 158 ENL.LALT........TTYYNEGHCVLEKVAATQVDGS.....AKYKV.TRISGEk.......EV 159 ENL.LALT........TTYYNEGHCVLEKVAATQVDGS.....AKYKV.TRISGEk.......EV 160 GAA.MAVS........TFRKLDGICWQVSQRYGATGVP.....GRFLL.PARGPRgav.....HV 161 ECQtLTIK........FYTKVENVCQEHRVVGRKGKD-.....GKYIT.DFSGQN........YF 162 EGD.LEIL........LQKLENDECAQLVAKKEKTNIP.....AVFKTlEVINEN........RV 163 KESkVYLN........FFSKENGICEEFSLIGTKQEG-.....NTYDV.NYAGNN........KF 164 RCNqVYLY........FFIKKGTKCQLYKVIGRKKQE-.....-VYYA.QYEG-S........IA 165 NGH.MKSS........TSFQTEKGCQQMDVEMTTVEK-.....GHYKW.KMQQGDs.......ET 166 GGN.LEAK........VTMLISGRCQEVKAVLEKTDEP.....GKYTA.-DGGKH........VA 167 INR.ITGN........PnVNIGYATPENSRSSIMDFKF.....T-TRF.PDVIAR........LL 168 DGD.MKLT........ANYMSDGVCKTSVLVLKHTDKP.....GVFKV.---PDG........EV 169 ECKeMKVT........FYVNENGQCSLTTITGYLQEDG.....KTYKT.QFQGNN........RY 170 RCNrINLY........FYIKKGAKCQQFKIVGRRSQD-.....-VYYA.KYEG-S........TA 171 INR.ITGN........PnVNIGYATPENSRSSIMDFKF.....T-TRF.PDVIAR........LL 172 NGK.TTATakgrv...RILDKLELCANMVGTFIETNDP.....AKYRM.KYHGALailergldDH 173 KESkVYLN........FFSKENGICEEFSLIGTKQEG-.....NTYDV.NYAGNN........KF 174 --S.LVFK........FHLIVNEECTEMTAIGEQTEKA.....GIYYM.NYDGFN........TF 175 KESkVYLN........FFSKENGICEEFSLIGTKQEG-.....NTYDV.NYAGNN........KF 176 QGD.LEIF........LQK-------------EKTEIP.....AVFXX.NFLN--........-- 177 GGN.LEAT........FTFMREDRCIQKKILMRKTEEP.....GKFSA.-YGGRK........LI 178 EGN.LELV........LLEKT-DRCVEKKLLLKKTQKP.....TEFEI.YISSESasy.....TF 179 GGN.LEAT........FTFMREDRCIQKKILMRKTEEP.....GKFSA.-YGGRK........LI 180 GKK.ASVY........NSFVINGVKEYMEGDLEIAPDAkltkqGKYVM.TFKFGPrvvvq...VP 181 GKK.ASVY........NSFVSNGVKEYMEGDLEIAPDAkytkqGKYVM.TFKFGQrvvnl...VP 182 GKK.ASVY........NSFVVNGVKEYMEGDLEIAPDAkytkqGKYVM.TFKFGQrvvnl...VP 183 GGK.LEAT........FTFMREDRCIQKKILMRKTEEP.....GKYS-.------........-- 100 110 120 130 140 150 | | | | | | 1 FLLDTDYDSHLLLCMENSAS....PEHSL..VCQSLARTLE.VDDQIREKFEDALKTLSVPMRIL 2 LVLDTDYKKYLLFCMENSAE....PEQSL..VCQCLVRTPE.VDDEALEKFDKALKALPMHIRLS 3 LVLDTDYKKYLLFCMENSAE....PEQSL..VCQCLVRTPE.VDDEALEKFDKALKALPMHIRLS 4 LVLDTDYKKYLLFCMENSAE....PEQSL..VCQCLVRTPE.VDDEALEKFDKALKALPMHIRLS 5 LVLDTDYKKYLLFCMENSAE....PEQSL..ACQCLVRTPE.VDDEALEKFDKALKALPMHIRLS 6 LVLDTDYKKYLLFCMENSAE....PEQSL..ACQCLVRTPE.VDDEALEKFDKALKALPMHIRLS 7 LVLDTDYKKYLLFCMENSAE....PEQSL..VCQCLVRTPE.VDDEALEKFDKALKALPMHIRLS 8 LVLDTDYKKYLLFCMENSAE....PEQSL..ACQCLVRTPE.VDNEALEKFDKALKALPMHIRLA 9 LVLDTDYKKYLLFCMENSAE....PEQSL..ACQCLVRTPE.VDDEALEKFDKALKALPMHIRLS 10 LVLDTDYKKYLLFCMENSAE....PEQSL..ACQCLVRTPE.VDNEALEKFDKALKALPMHIRLA 11 LVLDTDYKKYLLFCMENSAE....PEQSL..ACQCLVRTPE.VDDEALEKFDKALKALPMHIRLS 12 LVLDTDYKKYLLFCMENSAE....PEQSL..ACQCLVRTPE.VDKEALEKFDKALKALPMHIRLA 13 LVLDTDYKKYLLFCMENSAE....PEQSL..ACQCLVRTPE.VDNEALEKFDKALKALPMHIRLA 14 LVLDTDYKKYLLFCMENSAE....PEQSL..ACQCLVRTPE.VDNEALEKFDKALKALPMHIRLA 15 LVLDTDYKKYLLVCMENSAE....PEQSL..VCQCLVRTPE.VDDEALEKFDKALKALPMHIRLS 16 FLLDTDYDSHLLLCMENSAS....PEHSL..VCQSLARTLE.VDDQIREKFEDALKTLSVPMRIL 17 FLLDTDYDSHLLLCMENSAS....PEHSL..VCQSLARTLE.VDDQIREKFEDALKTLSVPMRIL 18 FALDTDYKNYLFLCMKNAAT....PGQSL..VCQYLARTQM.VDEEIMEKFRRALQPLPGRVQIV 19 IVLDTDYENYLFFCLENADA....PDQNL..VCQCLTRTLK.ADNEVMEKFDRALQTLPVHVRLF 20 LVLDTDYKKYLLFCMENSAE....PEQSL..VCQCLVRTPE.VDDEALEKFDKALKALPMHIRLS 21 IVLDTDYENYLFFCLENADA....PGQNL..VCQCLTRTLK.ADNEVMEKFDRALQTLPVDVRLF 22 FLLDTDYDNYLFFCEMNADA....PQQSL..MCQCLARTLE.VDNEVMEKFNRALKTLPVHMQLL 23 FALDSDYKNYLFLCMKNAAT....PGQSL..VCQYLARTQM.VDEEIMEKFRRALQPLPGRVQIV 24 FYLDTDYKNYLFLCMKNAAT....PGQSL..VCQYLARTQM.VDEEIMEKFRRALQPLPGRVQIV 25 SVLDTDYTHYMFFCMEAPAPg...TENGM..MCQYLARTLK.ADNEVMEKFDRALQTLPVHIRII 26 IVLDTDYENYLFFCLENTDA....PGQNL..VCQCLTRTLK.ADNEVMEKFDRALQTLPVDVRLF 27 SVLDTDYTHYMFFCMEAPAPg...TENGM..MCQYLARTLK.ADNEVMEKFDRALQTLPVDIRII 28 FLLDTDYDNYLFFCMENANA....PQQSL..MCQCLARTLE.VNNEVIGKFNRALKTLPVHMQLL 29 IVLDTDYENYLFFCLENTDA....PGQNL..VCQCLTRTLK.ADNEVMEKFDRALQTLPVHVRLF 30 IVLDTDYENYLFFCLENADA....PDQNL..VCQCLTRTLK.ADNEVMEKFDRALQTLPVHVRLF 31 SVLDTDYTHYMFFCMEAPAPg...TENGM..MCQYLARTLK.ADNEVMEKFDRALQTLPVHIRII 32 SVLDTDYTHYMFFCMEAPAPg...MENGM..MCQYLARTLK.ADNEVMEKFDRALQTLPVHIRII 33 FLLDTDYDNYLFFCMENANA....PQQSL..MCQCLARTLE.VNNEVIGKFNRALKTLPVHMQLL 34 SVLDTDYAHYMFFCVGPCLPs...AEHGM..VCQYLARTQK.VDEEVMEKFSRALQPLPGHVQII 35 IVLDTDYENYLFFCLENTDA....PGQNL..VCQCLTRTLK.ADNEVMEKFDRALQTLPVDVRLF 36 WVVATNYEEYALLYTAGSKGl...GQDFH..MATLYSRTQT.PKAEIKEKFSTFAKTQGFTEDAI 37 TILKTDYDNYVMFHLVNVNN....GETFQ..LMELYGRTKD.LSSDIKEKFAKLCVAHGITRDNI 38 TILKTDYDNYVMFHLVNVNN....GETFQ..LMELYGRTKD.LSSDIKEKFAKLCVAHGITRDNI 39 SVLDTDYAHYMFFCVGPPLPs...AEHGM..VCQYLARTQK.VDEEVMEKFSRALQPLPGRVQIV 40 WVAMTDYDEYALLYTTGTKGl...GQDFH..MATLYSRTQT.PRAEIKEKFTTFAKTQGFTEDAI 41 WVVATDYEEYALLYTAGTKSp...GQDFH..MATLYSRTQT.PRAEVKEKFSTFAKTRGFTEDAI 42 SVVETDYDHYALLYSQGSKGp...GEDFR..MATLYSRTQT.PRAELKEKFSAFCKAQGFTEDSI 43 SVVETDYDEYAFLFSKGTKGp...GQDFR..MATLYSRAQL.LKEELKEKFITFSKDQGLTEEDI 44 TILKTDYDNYIMFHLINEKD....GKTFQ..LMELYGRKAD.LNSDIKEKFVKLCEEHGIIKENI 45 WVVDTDYKEFALLYSEGAKGp...GQDFR..MATLYSRSQT.PGAELKQKFMAFCKAQGFTEDIV 46 FLLDTDYDSHLLLCMENASQ....-EHSL..VQQCLARTLE.VDDQIREKFEDALKTLSVPMRIL 47 SVVETDYDQYALLYSQGSKGp...GEDFR..MATLYSRTQT.PRAELKEKFTAFCKAQGFTEDTI 48 SVVETDYDHYALLYSQGSKGp...GEDFR..MATLYSRTQT.PRAELKEKFTAFCKAQGFTEDSI 49 SVVETDYDHYALLYSQGSKGp...GEDFR..MATLYSRTQT.PRAELKEKFTAFCKAQGFTEDSI 50 TLLDTDYDNFLFLCLQDTTT....PIQSM..MCQYLARVLV.EDDEIMQGFIRAFRPLPRHLWYL 51 TILKTDYDRYVMFHLINFKN....GETFQ..AMVLYGRTKD.LSSDIKEKFAKLCEAHGITRDNI 52 NILKTDYDRYVMFHLVNFKD....GETFQ..LMELYGRTKD.LSSDIKEKFAKLCVAHGITRENI 53 TLLDTDYDNFLFLCLQDTTT....PIQSM..MCQYLARVLV.EDDEIMQGFIRAFRPLPRHLWYL 54 RVVETNYDEYILMYTVKTKG....SETNQ..IVSLFGRDKD.LRPELLDKFQNFAKSQGLADDNI 55 SVAETDYETYALLYTEGVRGp...GQDFR..MATLYSRSQN.PRAEVKEHFTTFAKSLGFTEEGI 56 RVVETNYDEYILMYTVKTKG....SETNQ..IVSLFGRDKD.LRPELLDKFQNFAKSQGLADDNI 57 TILKTDYDRYVMFHLINFKN....GETFQ..AMVLYGRTKD.LSSDIKEKFAKLCEAHGITRDNI 58 SVAETDYETYALLYTESVRGp...GPDSL..MATLYSRTQT.PRAEVKEKFTTFARSLGFTEEGI 59 TILKTDYDRYVMFHLINFKN....GETFQ..AMVLYGRTKD.LSSDIKEKFAKLCEAHGITRDNI 60 RVVSTNYNQHAMVFFKKVSQ....NREYF..KITLYGRTKE.LTSELKENFIRFSKSLGLPENHI 61 NILKTDYDRYVMFHLVNFKD....GETFQ..LMNLLGRTKD.LSSDIKEKFAKLCVAHGITRENI 62 RVVSTNYNQHAMVFFKKVSQ....NREYF..KITLYGRTKE.LTSELKENFIRFSKSLGLPENHI 63 RVVSTNYNQHAMVFFKKVSQ....NREYF..KITLYGRTKE.LTSELKENFIRFSKSLGLPENHI 64 RVVSTNYNQHAMVFFKKVSQ....NREYF..KITLYGRTKE.LTSELKENFIRFSKSLGLPENHI 65 RVVSTNYNQHAMVFFKKVSQ....NREYF..KITLYGRTKE.LTSELKENFIRFSKSLGLPENHI 66 TILKTDYDRYVMFHLINFKN....GETFQ..LMVLYGRTKD.LSSDIKEKFAKLCEAHGITRDNI 67 RVVSTNYNQHAMVFFKKVSQ....NREYF..KITLYGRTKE.LTSELKENFIRFSKSLGLPENHI 68 TILKTDYDRYVMFHLINFKN....GETFQ..LMVLYGRTKD.LSSDIKEKFAKLCEAHGITRDNI 69 TILKTDYDRYVMFHLVNFKN....GETFQ..LMELYGRTKD.LSSDIKEKFAKLCVAHGITRDNI 70 TILKTDYDRYVMIHLVNVKN....GETFQ..LMLLYGRTKD.LSSDIKEKFEKLCVAHGITRDNI 71 RVVESNYDEYTLMHTIKTKG....NEVNT..IVSLFGRRKT.LSPELLDKFQQFAKEQGLTDDNI 72 TIPKTDYDNFLMAHLINEKD....GETFQ..LMGLYGREPD.LMSDIKERFAQLCEEHGILRENI 73 TILKTDYDNYIMFHLINKKD....EENFQ..LMELFGREPD.LSSDIKEKFAKLCEEHGIVRENI 74 SVVETDYEEYALLYTHAESTkglgGQDFR..MATLYSRVQS.PRPEVKEKFSTFAKAQGFTEDAI 75 RVVSTNYNQHAMVFFKKVSQ....NREYF..KITLYGRTKE.LTSELKENFIRFSKYLGLPENHI 76 TIPKTDYDNFLMAHLINEKD....GETFQ..LMGLYGREPD.LSSDIKERFAQLCEEHGILRENI 77 TLLDTDYDNFLFLCLQDTTT....PIQSM..MCQYLARVLV.EDDEIMQGFIRAFRPLPRHLWYL 78 TIPKTDYDNFLMAHLINEKD....GETFQ..LMGLYGREPD.LSSDIKERFAQLCEEHGILRENI 79 TIPKTDYDNFLMAHLINEKD....GETFQ..LMGLYGREPD.LSSDIKERFAQLCEEHGILRENI 80 TIPKTDYDNFLMAHLINEKD....GETFQ..LMGLYGREPD.LSSDIKERFAQLCEKHGILRENI 81 TIPKTDYDNFLMAHLINEKD....GETFQ..LMGLYGREPD.LSSDIKERFAKLCEEHGILRENI 82 TIPKTDYDNFLMAHLINEKD....GETFQ..LMGLYGREPD.LSSDIKERFAQLCEEHGILRENI 83 NILKTDYDRYVMFHLVNFKD....GETFQ..LMNLFGRTKD.LSSDIKEKFAKLCVAHGITRENI 84 RVVSTNYNQHAMVFFKKVSQ....NREYF..KITLYGRTKE.LTSELKNNFIRFSKSLGLPENHI 85 YLFNTDGSKYLFLCLESTRR....--QNL..ACQYLARTLE.VDDKVMAEFISFLKTLPVHMQIF 86 TILKTDYERYVMFHLVNVNN....GEAFQ..LMELYGRTKD.LSSDIKEKFAKLCEAHGITRDNI 87 SVVETDYKNYALLHTESGPSp...GPAFR..MATLYSRSQA.PGAAVREKFTAFAKARGFTEDGI 88 TIPKTDYDNFLMAHLINEND....GETFQ..LMGLYGREPD.LSSDIKERFAQLCEKHGILRENI 89 SVVEANYDEYALLFSRGTKGp...GQDFR..MATLYSRTQT.LKDELKEKFTTFSKAQGLTEEDI 90 LSVETDYDEYAFLFSKRTKGp...GQDFR..MATLYSRAQL.LKEELKEKFITFSKDQGLTEEDI 91 TIPKTDYDNFLMAHLINEKD....GETFQ..LMGLYGREPD.LSSDIKERFAQLCEEHGILRENI 92 NYQPGERKNYLFLCMKDVGPclpsAEHGM..VCQYLARTQK.VDEEVMEKFSRALQPLPGRVQIV 93 EVLDTDYKSYAVIYATRVKD....GRTLH..MMRLYSRSPE.VSPAATAIFRKLAGERNYTDEMV 94 LVLDTDYKKYLLFCMENSAE....PEQSL..ACQCL-----.----------------------- 95 QVADTDYDQFAMVFFQKTSE....NKQYF..KVTLYGRTKG.LSDELKERFVSFAKSLGLKDNNI 96 EVLDTDYKSYAVIFATRVKD....GRTLH..MMRLYSRSRE.VSPTAMAIFRKLARERNYTDEMV 97 SILKTDYDNYIMIHLINKKD....GKTFQ..LMELYGREPD.LSLDIKEKFAKLCEEHGIIRENI 98 QVADTDYDQFAMVFFQKTSE....NKQYF..KVTLYGRTKG.LSDELKERFVSFAKSLGLKDNNI 99 EVLDTDYKSYAVIFATRVKD....GRTLH..MMRLYSRSRE.VSPTAMAIFRKLARERNYTDEMV 100 TILKTDYDRYVMFHLINFKN....GETFQ..LMVLYGRTKD.LSSDIKEKFAKLCEAHGITRDNI 101 EVLDTDYKSYAVIFATRVKD....GRTLH..MMRLYSRSRE.VSPTAMAIFRKLARERNYTDEMV 102 EVLDTDYKSYAVIFATRVKD....GRTLH..MMRLYSRSRE.VSPTAMAIFRKLARERNYTDEMV 103 YLQELPRRDHYIFYCKDQHH....GGLLH..MGKLVGRNSD.TNREALEEFKKLVQRKGLSEEDI 104 WIIDTDYETFAVQYSCRLLNl...DGTCAdsYSFVFARDPSgFSPEVQKIVRQRQEELCLARQYR 105 YLQELPGTDDYVFYCKDQRR....GGLRY..MGKLVGRNPN.TNLEALEEFKKLVQHKGLSEEDI 106 WIIDTDYETFAVQYSCRLLNl...DGTCAdsYSFVFARDPSgFSPEVQKIVRQRQEELCLARQYR 107 RISEFENDEHIILYLVNFDK....DRPFQ..LFEFYAREPD.VSPEIKEEFVKIVQKRGIVKENI 108 YLQELPGTDDYVFYCKDQRR....GGLRY..MGKLVGRNPN.TNLEALEEFKKLVQHKGLSEEDI 109 RISEFENDEHIILYLVNFDK....DRPFQ..LFEFYAREPD.VSPEIKEEFVKIVQKRGIVKENI 110 WIIDTDYETFAVQYSCRLLNl...DGTCAdsYSFVFARDPSgFSPQVQKIVRQRQEELCLARQYR 111 YIVFTNYNEYVIMQMRKKKG....SETTT..TVKLYGRSPD.LRPTLVDEFRQFALAQGIPEDSI 112 YSIPSAVEDHYIFYYEGKIH....RHHFQ..IAKLVGRNPE.INQEALEDFQNAVRAGGLNPDNI 113 YIIPSSVEDHYIFYYEGKIH....RHHFQ..IAKLVGRDPE.INQEALEDFQSVVRAGGLNPDNI 114 RLLEVNYSDYVILHLVNVNG....DKTFQ..LMEFYGRKPD.VEPKLKDKFVEICQQYGIIKENI 115 YVVDTNYDEYAIVMLSKQKTg...GEKTK..SAKLYSRTME.LPPTILEDFRRLVREQGMADDTI 116 FLEKVDPKHFVIFCAHSMKH....GKETV..VVTLFSRTPT.VSPDVMWMFKKYCKTHGIHTSNI 117 WIIDTDYDTFAVQYSCRLLNf...DGTCAdsYSFVFSRDPHgLPPDVQKLVRQRQEELCLSRQYR 118 WIVDTDYDTYAVQYSCRLLNl...DGTCAdsYSFVFSRDPNgLPPEAQKIVRQRQEELCLARQYR 119 YLAEVDPKSYLILYMINQYN....DDTSL..VAHLMVRDLS.RQQDFLPAFESVCEDIGLHKDQI 120 YVVHTNYDEYAIIIMSKQKTs...GENST..SLKLYSRTMS.VRDTVLDDFKTLVRHQGMSDDTI 121 WIIDTDYDTYAVQYSCRLQNl...DGTCAdsYSFVFARDPHgFSPEVQKIVRQRQEELCLARQYR 122 WIIDTDYDTYAVQYSCRLQNl...DGTCAdsYSFVFARDPHgFSPEVQKIVRQRQEELCLARQYR 123 WIIDTDYDTYAAQYSCRLQNl...DGTCAdsYSFVFARDPHgFSPEVQKIVRQRQEELCLARQYR 124 WIVDTDYDTYAVQYSCRLLNl...DGTCAdsYSFVFSRDPNgLPPEAQKIVRQRQEELCLARQYR 125 WIVDTDYDTYAVQYSCRLLNl...DGTCAdsYSFVFSRDPNgLPPQAQKIVRQRQEELCLARQYR 126 WVVDTDYDTYALHYSCRELNe...DGTCAdsYSFVFSRDPKgLPPEAQKIVRQRQIDLCLDRKYR 127 WIVDTDYDTYAVQYSCRLLNl...DGTCAdsYSFVFSRDPNgLPPEAQKIVAQRQEELCLAAQYR 128 YTKEIPVKDHYIFYIKGQRH....GKSYL..KGKLVGRDSK.DNPEAMEEFKKFVKSKGFREENI 129 FIQPSPVRDHYILYCEGELH....GRQIR..MAKLLGRDPE.QSQEALEDFREFSRAKGLNQEIL 130 WIIDTDYDTYAVQYSCRLLNl...DGTCAdsYSFVFARDPNgFPPEVQRIVRRRQEELCLARQYR 131 YYGSSKPNEYAKFIFYNYHD....GKVNV..VANLFGRTPN.LSNEIKKRFEEDFMNRGFRRENI 132 SVVEANYDEYALLFSRGTKGp...GQDFR..MATLYSRTQT.LKDELKEKFTTFSKAQGLTEEDI 133 CVMETDYDSYFLFCLYNISD....REK-M..ACAHYVRRIE.EN-KGMNEFKKILRTLAMPYTVI 134 SVMETDYDSYFLFCLYNISD....REK-M..ACAHYVRRIE.EN-KGMNEFKKILRTLAMPYTVI 135 HVLDVDFEKYIMLYVKKSSH....----E..ALFLSARGPD.VEDDIKEKFKKLVLEQSFPEANI 136 QPLYITSDK-IFFTNKNMDRa...GQETN..MIVVAGKGNA.LTPEENEILVQFAHEKKIPVENI 137 QPLYITSDK-IFFTNKNMDRa...GQETN..MIVVAGKGNA.LTPEENEILVQFAHEKKIPVENI 138 RMMDIDYEKYLIMYMKKS--....--TFE..AMYLSARGSD.VGDDIKEKFKKLVLEQNFPEAHI 139 RMMDIDYEKYLIMYMKKS--....--TFE..AMYLSARGSD.VGDDIKEKFKKLVLEQNFPEAHI 140 WVIDTDYDNYAIHYSCREVDl...DGTCLdgYSFIFSRHPTgLRPEDQKIVTDKKKELCFLGKYR 141 QPLYITSDK-IFFTNKNMDRa...GQETN..MIVVAGKGNA.LTPEENEILVQFAHEKKIPVENI 142 TIPKTDYDNFXMAHLINEKD....GETFQ..LMGLYGREPD.LSSDIKERFAKLCEEHGILRENI 143 TLLDTDYDNFLFLCLQDTTT....PIQSM..MCQYLARVLV.EDDEIMQGFIRAFRPLPRHLWYL 144 WVIDTDYDNYAIHYSCREVDl...DGTCLdgYSFIFSRHPTgLRPEDQKIVTDKKKEICFLGKYR 145 WIIDTDYDNYAIHYSCRELDe...DGTCLdgYSFIFSRHPDgLRPEDQAIVTQKKQDICFLGKYR 146 QVQLSSVKGHYMLYCDGEIE....GMRFL..MTQLIGRDPQ.ENLEALEEFKVFTQIKGLVAENL 147 QVQLSSVKGHYMLYCDGEIE....GMRFL..MTQLIGRDPQ.ENLEALEEFKVFTQIKGLVAENL 148 EVIHVS-ENMLVTYVENYDG....ERITK..MTEGLAKGTS.FTPEELEKYQQLNSERGVPNENI 149 YILPSKVKDHYILYCEGELD....GQEVR..MAKLVGRDPE.NNPEALEEFKEVARAKGLNPDIV 150 EVIHVS-ENMLVTYVENYDG....ERITK..MTEGLAKGTS.FTPEELEKYQQLNSERGVPNENI 151 YILPSKVKDHYILYCEGELD....GQEVR..MAKLVARDPE.NNPEALEEFKEVARAKGLNPDIV 152 VVEATDYLTYAIIDITSLVA....GAVHR..TMKLYSRSLD.DNGEALYNFRKITSDHGFSETDL 153 VVEATDYLTYAIIDITSLVA....GAVHR..TMKLYSRSLD.DNGEALYNFRKITSDHGFSETDL 154 VVEATDYLTYAIIDITSLVA....GAVHR..TMKLYSRSLD.DNGEALYNFRKITSDHGFSETDL 155 WVIATDYDNYAIHYSCRVVDs...DGTCLdsYSFVFSRHATgLRQEDVEIIVQKKTELCLLHKYR 156 SVMETDYDNYILGCLENVNY....REK-M..ACAHYERRIE.EN-KGMEEFKKIVRTLTIPYTMI 157 VVAETDYQSFAVLYLERAGQ....----L..SVKLYARSLP.VSDSVLSGFEQRVQEAHLTEDQI 158 VVVATDYMTYTVIDITSLVA....GAVHR..AMKLYSRSLD.NNGEALNNFQKIALKHGFSETDI 159 VVVATDYMTYTVIDITSLVA....GAVHR..AMKLYSRSLD.NNGEALNNFQKIALKHGFSETDI 160 VAAETDYHSFAVLYLERARQ....----L..SVKLYVRSLP.VSDSVLGAFEQRVAQANLTQDQV 161 HVVEKA-DDTMTFHNVNVDD....SGKTN..VILVVGKGES.SSIEQKQRFEKTAEKYDIPKENI 162 LVLDTD--------------....-----..----------.---AIKEALEKFDKTLPMSVRIR 163 VVSYAS-ETALIISNINVDEe...GDKTI..MTGLLGKGTD.IEDQDLEKFKEVTRENGIPEENI 164 FMLKMVNEKILLFHYFNKNRr...NDVTR..VAGVLAKGKQ.LNKEEMTEFMNLVEEMGIEEENV 165 IIVATDYDAFLMEFTKIQMG....AEVCV..TVKLFGRKDT.LPEDKIKHFEDHIEKVGLKKEQY 166 YIIRSHVKDHYIFYCEGELH....GKPVR..GVKLVGRDPK.NNLEALEDFEKAAGARGLSTESI 167 PGSGKYQVLYTDYENFAILW....SCGSI..GsLGHSDQIW.ILGRDRDFEVDIRSKVYDVLKRL 168 HVIKM-----LILKSISFFTsk..KPTHE..ALFLSARGST.GGDDIKAKFKKLVWEQIILEAHI 169 KLVDESPEN-LTFYSENVDRa...DRKTK..LLFILGHGP-.LTSEQKEKFAELAEEKGIPAGNI 170 FMLKTVNEKILLFDYFNRNRr...NDVTR..VAGVLAKGRQ.LTKDEMTEYMNFVEEMGIEDENV 171 PGSGKYQVLYTDYENFAILW....SCGSI..GsLGHSDQIW.ILGRDRDFEVDIRSKVYDVLKRL 172 WVVDTDYTTYAITYACRRRNl...DGTCRdsYSFVFSRDINgLPSESQRIVRRRQEQLCLDRKYR 173 VVSYAS-ETALIISNINVDEe...GDKTI..MTGLLGKGTD.IEDQDLEKFKEVTRENGIPEENI 174 SILKTDYDNYIMIHLINKKD....GKTFQ..LMELYGREPD.LSLDIKEKFAKLCEEHGIIRENI 175 VVSYAS-ETALIISNINVDEe...GDKTI..MTGLLGKGTD.IEDQDLEKFKEVTRENGIPEENI 176 ----SDYTNYLLFCME----....--VSL..TCQYLARTLQ.VDDGVMEKFNKAIKPLPMHIRLX 177 YLQELPGTDDYVFYCKDQRR....GGLRY..MGKLVA----.----------------------- 178 SVMETDYDSYFLFCLYNISD....REK-M..ACAHYVRRIE.EN-KGMNEFKKILRTLAMPYTVI 179 YLQELPGTDDYVFYCKDQRR....GGLRY..MGKLV-----.----------------------- 180 WVLATDYKNYAINYNCNYHPdk..KAHSI..HAWVLSRNKV.LEGNTKEVVDNVLKTFSHLID-- 181 WVLATDYKNYAINYNCDYHPdk..KAHSI..HAWILSKSKV.LEGNTKEVVDNVLKTFSHLIDA- 182 WVLATDYKNYAINYNCNYHPdk..KAHSI..HAWILSKSKV.LEGNTKEVVDNVLKTFSHLIDA- 183 --------------------....-----..----------.----------------------- 160 | 1 ..PAQLEEQCRV 2 fnPTLQEEQCHI 3 fnPTQLEEQCHI 4 fnPTQLEEQCHI 5 fnPTQLEEQCHV 6 fnPTQLEEQCHV 7 fnPTQLEEQCHI 8 fnPTQLEGQCHV 9 fnPTQLEEQCHI 10 fnPTQLEGQCHV 11 fnPTQLEEQCHI 12 fnPTQLEGQCHV 13 fnPTQLEGQCHV 14 fnPTQLEGQCHV 15 fnPTQLEEQCHI 16 ..PAQLEEQCRV 17 ..PAQLEEQCRV 18 pdLTRMAERCRI 19 fdPTQVAEQCRI 20 fnPTQLEEQCHI 21 fdPTQVAEQCRI 22 n.PTQAEEQCL- 23 pdLTRMAERCRI 24 pdLTRMAERCRI 25 ldLTQGKEQCRV 26 fdPTQVAEQCRV 27 ldLTQGEKQCRV 28 n.PTQVEEQCL- 29 fdPTQVAEQC-- 30 fdPTQVAEQCRI 31 ldLTQGKEQCRV 32 ldLTQGKEQCRV 33 n.PTQVEEQCL- 34 qdPSGGQERC-- 35 fdPTQVAEQC-- 36 v.FLPQTDKC-- 37 i.DLTKTDRC-- 38 i.DLTKTDRC-- 39 qdPSGGQERC-- 40 v.FLPQTDKC-- 41 v.FLPKTERC-- 42 v.FLPQTDKC-- 43 v.FLPQPDKC-- 44 i.DLTKTNRC-- 45 v.FLPRNDKC-- 46 ..PAQLEEQCRV 47 v.FLPQTDKC-- 48 v.FLPQTDKC-- 49 v.FLPQTDKC-- 50 ldLKQMEEPCR- 51 i.DLTKTDRC-- 52 i.DVTKTDRC-- 53 ldLKQMEEPCR- 54 i.ILPHTDQC-- 55 v.FLPKTDKC-- 56 i.ILPHTDQC-- 57 i.DLTKTDHC-- 58 v.FLPKTDKC-- 59 i.DLTKTDHC-- 60 v.FPVPIDQC-- 61 i.DVTKTDRC-- 62 v.FPVPIDQC-- 63 v.FPVPIDQC-- 64 v.FPVPIDQC-- 65 v.FPVPIDQC-- 66 i.DLTKTDRC-- 67 v.FPVPIDQC-- 68 i.DLTKTDRC-- 69 i.DLTKTDRC-- 70 i.DLTKTDRC-- 71 l.ILPQTDSC-- 72 i.DLSNANRC-- 73 i.DLSNANRC-- 74 v.FLPQTDKC-- 75 v.FPVPIDQC-- 76 i.DLSNANRC-- 77 ldLKQMEEPCR- 78 i.DLSNANRC-- 79 i.DLSNANRC-- 80 i.DLSNANRC-- 81 i.DLSNANRC-- 82 i.DLSNANRC-- 83 i.DVTKTNRC-- 84 v.FPVPIDQC-- 85 ldMTQAEEQCRV 86 i.DLTKTDRC-- 87 v.FLPRNEKC-- 88 i.DLSNANRC-- 89 v.FLPQPDKC-- 90 v.FLPQPDKC-- 91 i.DLSNANRC-- 92 qdPSGGQERC-- 93 a.MLPRQEECTV 94 ..---------- 95 v.FSVPTDQC-- 96 a.VLPSQEECSV 97 i.DLTNVNRC-- 98 v.FSVPTDQC-- 99 a.VLPSQEECSV 100 ..---------- 101 a.VLPSQEECSV 102 a.VLPSQEECSV 103 f.TPLQTGSC-- 104 ..LIPHNGYC-- 105 f.MPLQTGSC-- 106 ..LIPHNGYC-- 107 i.DLTKIDRC-- 108 f.TPLQTGSC-- 109 i.DLTKIDRC-- 110 ..LIPHNGYC-- 111 v.MLPNNGEC-- 112 f.IPKQSETC-- 113 f.IPKQSETC-- 114 i.DLTKIDRC-- 115 i.IKQNKGEC-- 116 v.DLTQTDRC-- 117 ..LIVHNGYC-- 118 ..LIVHNGYC-- 119 v.VLSDDDRC-- 120 i.IKQNKGDC-- 121 ..IITHNGYC-- 122 ..IITHNGYC-- 123 ..LITHNGYC-- 124 ..LIVHNGYC-- 125 ..LIVHNGYC-- 126 ..VIVHNGFC-- 127 ..LIVHNGYC-- 128 t.VPELLDEC-- 129 ..ELAQSETC-- 130 ..LISHNGYC-- 131 l.DISEVDHC-- 132 v.FLPQPDKC-- 133 ..EVRTRDMCHV 134 ..EVRTRDMCHV 135 ..KYFNAEQC-- 136 l.NILATDTC-- 137 l.NILATDTC-- 138 ..KYFNAEQC-- 139 ..KYFNAEQC-- 140 ..RVSHTGFC-- 141 l.NILATDTC-- 142 i.DLSNANRC-- 143 ldLKQMEEPCR- 144 ..RVGHTGFC-- 145 ..RVAHTGFC-- 146 v.ILEQMEKC-- 147 v.ILEQMEKC-- 148 e.NLIKTDNC-- 149 ..RPQQSETC-- 150 e.NLIKTDNC-- 151 ..RPQQSETC-- 152 ..YILK------ 153 ..YILK------ 154 ..YILK------ 155 ..RVAHTGFC-- 156 ..EAQTREMCRV 157 f.YFPKYGFC-- 158 ..HILKH----- 159 ..HILKH----- 160 l.FFPTYGFC-- 161 e.HLVTTDTC-- 162 ..PALQEEQCL- 163 v.NIIERDDC-- 164 q.RIMDTDNC-- 165 i.RFHTKATC-- 166 l.IPRQSETC-- 167 ..SLDPERLIIS 168 ..KYLNVEQC-- 169 r.EVLITDYC-- 170 q.RVMDTDTC-- 171 ..SLDPERLIIS 172 ..VVVHNGYC-- 173 v.NIIERDDC-- 174 i.DLTNVNRC-- 175 v.NIIERDDC-- 176 ..---------- 177 ..---------- 178 ..EVRTRDMCHV 179 ..---------- 180 ..---------- 181 ..---------- 182 ..---------- 183 ..----------