; SAM: prettyalign v3.2 (June, 2000) compiled 07/10/00_09:40:44 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequence numbers correspond to the following labels: ; 1 T0117 ; 2 gi|4741228|emb|CAB41881.1|_4:249 ; 3 gi|6502515|gb|AAF14342.1|U90524_1_19:270 ; 4 gi|2497574|sp|O00142|KITM_HUMAN_3:232 ; 5 gi|4456608|emb|CAA71523.2|_5:230 ; 6 gi|2833282|sp|Q16854|DGK_HUMAN_21:270 ; 7 gi|7304999|ref|NP_038792.1|_20:270 ; 8 gi|1905974|gb|AAC51168.1|_2:222 ; 9 gi|4503319|ref|NP_001920.1|_4:253 ; 10 gi|7434490|pir||S71315_4:253 ; 11 gi|4877289|emb|CAB43122.1|_2:239 ; 12 gi|6424683|gb|AAF08104.1|AF105217_1_38:269 ; 13 gi|4503269|ref|NP_000779.1|_3:257 ; 14 gi|6681141|ref|NP_031858.1|_3:257 ; 15 gi|1352235|sp|P48769|DCK_RAT_3:257 ; 16 gi|4494925|gb|AAD21347.1|_211:445 ; 17 gi|7330010|gb|AAF59999.1|AF210726_20_211:445 ; 18 gi|4019247|gb|AAC95545.1|_190:439 ; 19 gi|7271649|gb|AAF44495.1|AF198100_142_9:230 ; 20 gi|2370245|emb|CAA73635.1|_190:438 ; 21 gi|125448|sp|P21293|KITH_HSVSA_190:438 ; 22 gi|1246355|gb|AAA93507.1|_266:498 ; 23 gi|118822|sp|P14344|KITH_VZVW_1:217 ; 24 gi|118821|sp|P14343|KITH_VZVG_1:217 ; 25 gi|118820|sp|P09250|KITH_VZVD_1:217 ; 26 gi|118818|sp|P14341|KITH_VZV4_1:217 ; 27 gi|1246358|gb|AAA93509.1|_3:218 ; 28 gi|5732886|gb|AAD49322.1|_1:217 ; 29 gi|1072623|pir||C56604_107:338 ; 30 gi|1246776|emb|CAA63755.1|_308:540 ; 31 gi|2317936|gb|AAB66394.1|_308:540 ; 32 gi|118819|sp|P14342|KITH_VZV7_1:217 ; 33 gi|5732882|gb|AAD49321.1|_1:217 ; 34 gi|1360832|pir||S55615_275:516 ; 35 gi|586859|sp|P37529|YAAF_BACSU_3:213 ; 36 gi|7444320|pir||T03116_219:438 ; 37 gi|462450|sp|P33802|KITH_HSVBM_217:436 ; 38 gi|1136820|gb|AAB08396.1|_235:468 ; 39 gi|66705|pir||KIBETE_266:498 ; 40 gi|1170666|sp|P03177|KITH_EBV_266:498 ; 41 gi|140631|sp|P21974|YF26_FOWP1_10:216 ; 42 gi|7428050|pir||G70129_5:198 ; 43 gi|125445|sp|P28855|KITH_HSVI1_6:210 ; 44 gi|7471796|pir||F75535_2:195 ; 45 gi|3023658|sp|Q59483|DGK1_LACAC_1:211 ; 46 gi|687841|gb|AAA62532.1|_54:304 ; 47 gi|464254|sp|P34942|NUDM_BOVIN_28:262 ; 48 gi|833830|gb|AAB04138.1|_4:224 ; 49 gi|4033719|gb|AAC97156.1|_1:204 ; 50 gi|7461161|pir||T03086_1:192 ; 51 gi|4758768|ref|NP_004535.1|_50:274 ; 52 gi|3023659|sp|Q59484|DGK2_LACAC_1:213 ; 53 gi|586860|sp|P37530|YAAG_BACSU_5:202 ; 54 gi|7471797|pir||G75535_1:195 ; 55 gi|7461850|pir||T17919_1:186 ; 56 gi|1723139|sp|P47510|Y268_MYCGE_14:216 ; 57 gi|7469438|pir||S76121_24:234 ; 58 gi|2496356|sp|P75396|Y268_MYCPN_16:219 ; 59 gi|8247943|sp|Q55593|KTHY_SYNY3_2:210 ; 60 gi|6899038|gb|AAF30491.1|AE002108_4_21:225 ; 61 gi|3769437|gb|AAC64514.1|_4:216 ; 62 gi|125440|sp|P22649|KITH_HSVBH_5:212 ; 63 gi|1074411|pir||A64153_11:230 ; 64 gi|7493480|pir||T41553_7:201 ; 65 gi|5926720|dbj|BAA23726.2|_1:166 ; 66 gi|6015696|emb|CAB57523.1|_3:184 ; 67 gi|8134528|sp|Q9YA48|KTHY_AERPE_1:197 ; 68 gi|7483979|pir||C69413_38:238 ; 69 gi|1730073|sp|P44719|KTHY_HAEIN_1:203 ; 70 gi|547813|sp|P36590|KTHY_SCHPO_7:201 ; 71 gi|7446649|pir||H75067_2:174 ; 72 gi|6016458|sp|O30175|KTHY_ARCFU_1:189 ; 73 gi|7481957|pir||S77770_2:149 ; 74 gi|7518683|pir||F71164_2:176 ; 75 gi|7519788|pir||T12903_1:138 ; 76 gi|7449772|pir||D70470_1:190 ; 77 gi|7463781|pir||H70198_65:234 ; 78 gi|3123135|sp|O28278|YK01_ARCFU_1:147 ; 79 gi|7939517|dbj|BAA95720.1|_14:191 ; 80 gi|7450211|pir||H75093_1:152 10 20 30 40 50 | | | | | 1 MAEAASCARKGTKYAEGTQPFTVLIEGNIGSGKTT....YLNHFEKY......KNDICLLTEPVE 2 ---AASCARKGTKYAEGTQPFTVLIEGNIGSGKTT....YLNHFEKY......KNDICLLTEPVE 3 LRNCFVDAPHARAMHDGGGPRRLCIEGNIAVGKST....FVKLLMKT......HPEWQVATEPIA 4 ---AFCQRPSSDKEQEKEKKSVICVEGNIAGGKTT....CLEFFSNA......-TDVEVLTEPVS 5 -------AWPPDKEQEKEKKSVICVEGNIASGKTT....CLEFFSNA......-TDVEVLTEPVS 6 --SPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKST....FVKLLTKT......YPEWHVATEPVA 7 -RNALVDAPHARAMHDGGGPRRLCIEGNIAVGKST....FVKLLMKT......HPEWQVATEPIA 8 ------------KEQEKEKKSVICVEGNIAGGKTT....CLEFFSNA......-TDVEVLTEPVS 9 --SPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKST....FVKLLTKT......YPEWHVATEPVA 10 --SPLEGVSSSRGLHAGCGPRRLSIEGNIAVGKST....FVKLLTKT......YPEWHVATEPVA 11 --------------HDGGGPRRLCIEGNIAVGKST....FVKLLMKT......HPEWQVATEPIA 12 --PRRAWPPDKDRENDKEKKAVVCIEGNIASGKTT....CLEFFSNT......-TDVEVLMEPVL 13 -TPPKRSCPSFSASSEGTRIKKISIEGNIAAGKST....FVNILKQL......CEDWEVVPEPVA 14 -TPPKRFCPSPSTSSEGTRIKKISIEGNIAAGKST....FVNILKQA......SEDWEVVPEPVA 15 -TPPKRFCSSPSTSSEGTRIKKISIEGNIAAGKST....FVNILKQV......CEDWEVVPEPVA 16 PVTVPVHLMQPHPMTEYRNAFLIYLEGVMGVGKTT....LLNSMTGMvp....QENVLSCPEPMK 17 PVTVPVHLMQPHPMTEYRNAFLIYLEGVMGVGKTT....LLNSMTGMvp....QENVLSCPEPMK 18 LVHVPVHVLYPPLHQEPIPAFFIFLEGSIGVGKTT....LLKSMRGIlp....GKNVLTFHEPMA 19 -----SNLLKFENCSLLETHKKISIEGNISAGKST....LINILSD-......-NGYNVVQEPLE 20 LVHVPVHLLYPPMHQELVPAFFIFLEGSIGVGKTT....LLKSMNGIlg....GKNVLAFHEPIA 21 LVHVPVHLLYPPKHQDPVPAFFIFLEGSIGVGKTT....LLKSMNGIlg....GKNVLAFHEPIA 22 -MRVPIVTHLTNHVPVIKPACSLFLEGAPGVGKTT....MLNHLKAVf.....GDLTIVVPEPMR 23 --------MSTDKTDVKMGVLRIYLDGAYGIGKTTaaeeFLHHFAIT......PNRILLIGEPLS 24 --------MSTDKTDVKMGVLRIYLDGAYGIGKTTaaeeFLHHFAIT......PNRILLIGEPLS 25 --------MSTDKTDVKMGVLRIYLDGAYGIGKTTaaeeFLHHFAIT......PNRILLIGEPLS 26 --------MSTDKTDVKMGVLRIYLDGAYGIGKTTaaeeFLHHFAIT......PNRILLIGEPLS 27 ---------STDKTDVKMGVLRIYLDGAYGIGKTTaaeeFLHHFAIT......PNRILLIGEPLS 28 --------MSTDKTDVKMGVLRIYLDGAYGIGKTTaaeeFLHHFAIT......PNRILLIGEPLS 29 -KPAPAHLLYPRPPTGYTDAYFIFFEGVMGVGKTT....LLKTLARNd.....MNNVIIFEEAMN 30 -YSYMSKMSTDFPAGPTRCATVLYFDGGIAVGKTT....ALEAAAEF......LHNILVISEPIP 31 -YSYMSKMSTDFPAGPTRCATVLYFDGGIAVGKTT....ALEAAAEF......LHNILVISEPIP 32 --------MSTDKTDVKMGVLRIYLDGAYGIGKTTaaeeFLHHFAIT......PNRILLIGEPLS 33 --------MSTDKTDVKMGVLRIYLDGAYGIGKTTaaeeFLHHFAIT......PNRILLIGGPLS 34 PRDVFNTFLGSGTCPSFKNAFFLYLEGSMGVGKTT....LIRHMREIn.....GDNVISFVEPMF 35 -------------EHHIPKNSIITVAGTVGVGKST....LTKTLAKR......-LGFKTSLEEVD 36 CQPGFTPIFQDLGEPHYVKACTVFFEGCMAAGKTT....LLNFARQTls....DDEALTIPEPMR 37 CQPGFTPIFQDLGEPHYVKACTVFFEGCMAAGKTT....LLNFARQTls....DDEALTIPEPMR 38 -LMVPVHLIRTPVTVDYRNVYLLYLEGVMGVGKST....LVNAVCGIlp....QERVTSFPEPMV 39 -MRVPIVTHLTNHVPVIKPACSLFLEGAPGVGKTT....MLNHLKAVf.....GDLTIVVPEPMR 40 -MRVPIVTHLTNHVPVIKPACSLFLEGAPGVGKTT....MLNHLKAVf.....GDLTIVVPEPMR 41 --------------------KKLSIEGNISSGKTD....VLNILRNI......-NNVVSFHDVED 42 --------------------LVIVIEGLIGVGKTT....LGNILSKE......-LEVPFYSELNN 43 ---------GPTPARFLPEGLVFCVEGNIGCGKST....LVKALMERva....GSGVNVVEEPVD 44 ---------------------YVAVSGNIGSGKST....LTRMLAER......-YGLRPVYEPYA 45 -------------------MTVIVLSGPIGAGKSS....LTSLLAEH......-LGTQAFYEGVD 46 -FNYIDGLKDDTRSHFHQNSKLIVVEGNIGSGKTT....LAKQLADQ......-LGFVHFPEFRM 47 --PLAYILGEKATKKMTEKSKLITVDGNICSGKSK....LAKEIAEK......-LGLKHFPEAGI 48 ----------HGTCRDPVCITRVYLEGAFGIGKTT....TALAFVNGsr....VNPVFFIGEPMM 49 --------------------MLIVLAGTIGAGKSS....LAAALGEH......-LGTDVFYEAVD 50 -------------------MTIICIDGIIGAGKST....VTHRLKK-......-NLYKCYEEPID 51 ------------SKRLTERSRVITVDGNICTGKGK....LAKEIAEK......-LGFKHFPEAGI 52 -------------------MTVIVLSGPIGAGKSS....LTGILSKY......-LGTNPFYESVD 53 --------------------PFIAIEGPIGAGKTT....LATMLSQK......-FGFPMINEIVE 54 --------------------MYVVVEGPIGVGKTS....LAQRLAQR......-SGAELNLEVVE 55 --------------------MIISVDGLMGSGKTT....LLDRLEKR......--GFKVFREPVG 56 -------------------ANCIVIGGMIALGKTT....IANTLANH......IQAAKVVCELET 57 ----------------IMAALFIVLEGIDGSGKTTqgdlLLAHFQRQ......GLAAVLSPEPTN 58 --------------------NAVVVGGMIAFGKTT....IAESLAKH......LKGSKVIYELEE 59 ------------------AALFIVLEGIDGSGKTTqgdlLLAHFQRQ......GLAAVLSPEPTN 60 ---------------------SIAIGGMIAFGKST....LAQALHEK......YQPSNVVYEMVE 61 -------------------VLRIYLDGPHGIGKTT....LGSELTKVlah...RADVVFVPEPMA 62 --------------------LRVYVDGPHGLGKTT....AASRLASE......RGDAIYLPEPMS 63 YVGIAVRKMPNKSAEENMKGKFIVIEGLEGAGKSSahqsVVRVLHELg.....IQDVVFTREPGG 64 -------------------GRLIVIEGLDRSGKST....QCQLLVDKlisqheKAELFKFPDRTT 65 --------MSTDKTDVKMGVLRIYLDGAYGIGKTTaaeeFLHHFAIT......PNRILLIGEPLS 66 --------------------KLIAIEGIDGSGKTT....LANLLKEHleskm.KLNVIVTREPFS 67 -------------------MRIVALEGIDGSGVSThsrlLHARLAGA......GVKSCLWKEPTE 68 -AGQPERFNFNRNTILLDGMRFIVIDGMDGAGKDT....HAEFVRRRyae...RGSVIVRTHPSD 69 -----------------MKGKFIVIEGLEGAGKSSahqsVVRVLHELg.....IQDVVFTREPGG 70 -------------------GRLIVIEGLDRSGKST....QCQLLVDKl.....ILNMKRLKLFKF 71 ----------------GMEKMIVGIAGKIAAGKTT....VAKFLEEF......GFCRISCSEPLF 72 --------------------MLIAVEGIDGAGKTTiaayIAELLKEK......GYKVKVLKEPGD 73 -----------------------------------....--------......------------ 74 ----------------GVEKTIVGIAGKIAAGKTT....VAKFLEEL......GFCRISCSEPLL 75 -------------------MTLIILEGPDCCFKST....VAAKLSKE......------------ 76 -------------------MKRIGLTGNIGCGKST....VAQMFREL......-GAYVLDADKLI 77 -----------------------CIEGIDGSGKTS....ITNKLKALcnd...ESRYYFTKEPSS 78 --------------------MLIALTGTPGTGKSS....VAERLRER......GYKVATVVELAE 79 ----ISDYVSPSAPAPLKQPFVIGVAGGTASGKTT....VCNMIMSQ......LHDQRVVLVNQD 80 --------------------MLIAITGTPGVGKTT....IAKLLAEK......-LGYEY------ 60 70 80 90 | | | | 1 KWRNV........NGVNLLEL...MY........K...DPK...K.WAMPFQSYVTLTML.QSHT 2 KWRNV........NGVNLLEL...MY........K...DPK...K.WAMPFQSYVTLTML.QSHT 3 EWQNIqaa12tskRLGNLLEM...MY........Q...EPA...R.WSYTFQTLSFMSRL.KVQL 4 KWRNV........RGHNPLGL...MY........H...DAS...R.WGLTLQTYVQLTML.DRHT 5 KWRNV........RGHNPLGL...MY........H...DAS...R.WGLTLQTYVQLTML.DRHT 6 TWQNIqaa12taqSLGNLLDM...MY........R...EPA...R.WSYTFQTFSFLSRL.KVQL 7 AWQNIqaa12tskRLGNLLEM...MY........Q...EPA...R.WSYTFQTLSFMSRL.KVQL 8 KWRNV........RGHNPLGL...MY........H...DAS...R.WGLTLQTYVQLTML.DRHT 9 TWQNIqaa12taqSLGNLLDM...MY........R...EPA...R.WSYTFQTFSFLSRL.KVQL 10 TWQNIqaa12taqSLGNLLDM...MY........R...EPA...R.WSYTFQTFSFLSRL.KVQL 11 AWQNIqaa12tskRLGNLLEM...MY........Q...EPA...R.WSYTFQTLSFMSRL.KVQL 12 KWRNV........HGHNPLSL...MY........H...DAS...R.WGLTLQTYVQLTML.DQHT 13 RWCNVqst15sqkNGGNVLQM...MY........E...KPE...R.WSFTFQTYACLSRI.RAQL 14 RWCNVqst15sqkSGGNVLQM...MY........E...KPE...R.WSFTFQSYACLSRI.RAQL 15 RWCNVqst15sqkSGGNVLQM...MY........E...KPE...R.WSFIFQSYACLSRI.RAQL 16 FWTCV........YSNCLKEQrs.IV........K...QGT...H.GKLITSARVYACQS.KFAL 17 FWTCV........YSNCLKEQrs.IV........K...QGT...H.GKSITSARVYACQS.KFAL 18 FWKNV........F-SNSLDE...VY........KltlPAK...V.GSMTNSSKLLACQL.KFAA 19 QWR--........-GNNLLDK...LY........K...DPS...R.WAYTFQSHAFWTRT.KTYI 20 YWTDV........F-SNSLEE...VY........KltlPAK...V.GRTSNSAKLLACQL.KFAS 21 YWTDV........F-SNSLEE...VY........KltlPAK...V.GRTSNSAKLLACQL.KFAS 22 YWTHV........Y-ENAIKA...MH........KnvtRAR...H.GREDTSAEVLACQM.KFTT 23 YWRNL........AGEDAICG...IYgtq13vspE...DAQ...R.LTAHFQSLFCSPHA.IMHA 24 YWRNL........AGEDAICG...IYgtq13vspE...DAQ...R.LTAHFQSLFCSPHA.IMHA 25 YWRNL........AGEDAICG...IYgtq13vspE...DAQ...R.LTAHFQSLFCSPHA.IMHA 26 YWRNL........AGEDAICG...IYgtq13vspE...DAQ...R.LTAHFQSLFCSPHA.IMHA 27 YWRNL........AGEDAICG...IYgtq13vspE...DAQ...R.LTAHFQSLFCSPHA.IMHA 28 YWRNL........AGEDAICG...IYgtq13vspE...DAQ...R.LTAHFQSLFCSPHA.IMHA 29 YWKTV........F-SDCHKL...IYdvm.....K...MGK...H.GSFSVSSKLLACQM.KFLT 30 YWTST........FDKNVCQQ...IY........Dvv.KTK...E.KGKKHSKKVLQCQM.AFAQ 31 YWTST........FDKNVCQQ...IY........Dvv.KTK...E.KGKKHSKKVLQCQM.AFAQ 32 YWRNL........AGEDAICG...IYgtq13vspE...DAQ...R.LTAHFQSLFCSPHA.IMHA 33 YWRNL........AGEDAICG...IYgtq13vspE...DAQ...R.LTAHFQSLFCSPHA.IMHA 34 YWREV........Y-SDCVKL...IYsac.....K...PFN...L.GKMSTSKKVLSAQM.KFMT 35 H----........--NPYLEK...FY........H...DFE...R.WSFHLQIYFLAERF.KEQK 36 FWTEV........Y-TNVLSQ...IV........KinkECK...P.GKTSTTAELVSCQL.KFAT 37 FWTEV........Y-TNVLSQ...IV........KinkECK...P.GKTSTTAELVSCQL.KFAT 38 YWTRA........FTDCYKEI...SHlm......K...SGK...A.GDPLTSAKIYSCQN.KFSL 39 YWTHV........Y-ENAIKA...MH........KnvtRAR...H.GREDTSAEVLACQM.KFTT 40 YWTHV........Y-ENAIKA...MH........KnvtRAR...H.GREDTSAEVLACQM.KFTT 41 RYTPI........E-KELIRK...FH........E...NPS...R.WSYALQTHYCMKRV.RMHL 42 DFT--........--LAVLDK...FY........K...DKS...R.WAFPVQINFLNERF.KLIK 43 QWVNH........NGKNYLEL...SY........T...DPT...G.YAVPFQNLVFDSYV.NVQ- 44 E----........--NPYLED...FY........H...DMR...Q.YSFHSQVYFLSRRL.EQHL 45 N----........--NPILPL...YY........K...DMA...H.YTFLLNTYLLNHRL.AQIN 46 DDILVdry17parYRLPDISM...FY........K...NPS...GeLSAAMQDRIFNCRF.DQYL 47 HYVDSttg12vqfSGNCSLEK...FY........D...DPKsndG.NSYRLQAWLYASRL.LQYA 48 YWRNM........AGDDAING...IYgtq13isdN...DAQ...R.LTAYFQGLFCSPHS.MLHA 49 N----........--NPVLDF...YY........Q...DPK...K.YAFLLQIYFLNKRF.KSIK 50 KWT--........----LLPN...LY........N...DMK...K.YATPFQFQVLFSQY.DQYL 51 HYPDSttg12tdyNGNCSLEK...FY........D...DPRsndG.NSYRLQSWLYSSRL.LQYS 52 D----........--NPVLPL...FY........E...NPK...K.YAFLLQVYFLNTRF.RSIK 53 D----........--NPYLDK...FY........D...NIK...E.WSFQLEMFFLCHRY.KQLE 54 E----........--NPFLAK...FY........E...QPQ...A.YAFQVQAFFLLSRF.KQLS 55 EWK--........----FLNK...FY........K...NPK...K.YALALQLEILVSFT.KYT- 56 NDQLV........--ELLLAK...MY........Ers.DEL...L.YSPLFQLYFTLNRFgKYQN 57 GPVGR........LIRQALQGdlfTY........N...DAR...Q.FEAQMGYLFAADRH.YHLY 58 QDQLA........--DLLLAK...MY........Ern.DEL...L.YAPLFQLYFTLNRFnKYRK 59 GPVGR........LIRQALQGdlfTY........N...DAR...Q.FEAQMGYLFAADRH.YHLY 60 GDKLM........--DLLLAK...MY........Ere.NNV...L.FGSLFQLYFVLNRF.ANYK 61 YWRAV........GGVDTIAS...VYetatrc..D...NKE...I.SSEEASLIMANTQV.LMNM 62 YWSGA........GEDDLVAR...VYtaqhrm..D...RGE...I.DAREAAGVVLGAQL.TMST 63 TPL--........--AEKLRH...LI........KhetEEP...V.TDKAELLMLYAARI.QLVE 64 AIGKK........IDDYLKES...VQ........L...NDQ...V.IHLLFSANRWETIQ.YIYE 65 YWRNL........AGEDAICG...IYgtq13vspE...DAQ...R.LTAHFQSLFCSPHA.IMHA 66 E----........----DIIK...LI........E...KIG...W.NDPILLVLLFAADR.EIHV 67 GPV--........--GRLIRG...FL........R...STE...G.VDSDLMALLFAADR.LWGL 68 SLFGR........V---AKAS...LL........R...RGK...F.FHLMAAIFYFFDVI.YSLL 69 TPL--........--AEKLRH...LI........KhetEEP...V.TDKAELLMLYAARI.QLVE 70 PDRTT........AIGKKIDD...YLt.......E...SVQ...L.NDQVIHLLFSANRW.EPSI 71 DILTG........N-------...--........-...---...-.----TQGYSWVPEV.EFKG 72 SKFGKkik9eerlSPEEELEL...FL........K...DRE...I.D----------ARE.NILP 73 -----........--------...--........-...---...-.-----QIYMLTARS.KQLK 74 DILTG........N-------...--........-...---...-.----VSEYSWVPEV.NFKG 75 -----........-------L...KY........P...IIK...G.SSFELAKSGNEKLF.EHFN 76 HSFYR........KGHPVYEE...VVktf27kdeE...KLR...K.LEEITHRALYKEIE.KITK 77 GII--........--GEMIRK...QL........M...NFEnp.L.EESTFAYLYAADRH.DHLY 78 K----........--------...--........-...---...-.--------------.---- 79 SFYHS........LTKEKLNK...VH........Ey..NFD...H.PDAFNTEVLLSCME.KLRS 80 -----........--VNLRDF...AL........E...KGC...G.REVDGEVEVEIDEL.AYFV 100 110 120 130 140 | | | | | 1 APT........NKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFIEESI......H 2 APT........NKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFIEESI......H 3 EPIpgrllqa.EKSVRVFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLQEFan....R 4 RPQ........VSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNM......D 5 RPQ........VSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNM......D 6 EPFpekllqa.RKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFas....R 7 EPIpgrllqa.EKSVRVFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLQEFan....R 8 RPQ........VSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNM......D 9 EPFpekllqa.RKPVQIFERSVYSDRYIFAKNLFENDSLSDIEWHIYQDWHSFLLWEFas....R 10 EPFpekllqa.RKPVQIFERSVYSDRYIFAKNLFENDSLSDIEWHIYQDWHSFLLWEFas....R 11 EPIpgrllqa.EKSVRVFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLQEFan....R 12 RPQ........MSPVRLMERSIYSARYIFVENLYRSGKMPEVDYAILSEWFDWIVRNI......D 13 ASLngklkda.EKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFgq....S 14 ASLngklkda.EKPVLFFERSVYSDRYIFASNLYESDCMNETEWTIYQDWHDWMNSQFgq....S 15 ASLngslrda.EKPVLFFERSVYSDRYIFASNLYESDCMNETEWTIYQDWHDWMNSQFgq....S 16 PFRata21stkPANWIVFDRHLLSATVVFPLVHVKYNRLTPDHLFQILSLFSA-----......- 17 PFRata21stkPANWIVFDRHLLSATVVFPLVHVKYNRLTPDHLFQILSLFSA-----......- 18 PLLalk18nlsSNMWVMFDRHPLSATVVFPYMHYQNGFLSFSHLVHLWGSFRA-----......- 19 DALnk......NKGNIILERSVFSDKYIFATALHDIGYIDDTEWNIYNEYSKWMTEFM......D 20 PLLalk18llsSDMWVMFDRHPLSATVVFPYMHFQNGFLSFSHLIQLWSSFKA-----......- 21 PLLalk18llsSDMWVMFDRHPLSATVVFPYMHFQNGFLSFSHLIQLWSSFKA-----......- 22 PFRvla21vapLDCWILHDRHLLSASVVFPLMLLRSQLLSYSDFIQVLATFTA-----......- 23 KISalm16nkePYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPA-----......E 24 KISalm16nkePYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPA-----......E 25 KISalm16nkePYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPA-----......E 26 KISalm16nkePYKIMLSDRHPIASTICFPLSRYLVGDMSPAAPPGLLFTLPA-----......E 27 KISalm16nkePYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPA-----......E 28 KISalm16nkePYKIMLSDRHPIASTICFPLSGYLVGDMSPAALPGLLFTLPA-----......E 29 PLKslg22rsdVSHWVMFDRHALSACLVFPLVMLKSGMLSFEHFISLVSTFRA-----......- 30 PFHatq19dgtCNNYVLIDRHMVSPTVIFPCLFFRLGVLRFCDLLSLLSVFSA-----......- 31 PFHatq19dgtCNNYVLIDRHMVSPTVIFPCLFFRLGVLRFCDLLSLLSVFSA-----......- 32 KISalm16nkePYKIMLSDQHPIASTICFPLSRYLVGDMSPAALPGLLFTLPA-----......E 33 KISalm16nkePYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPA-----......E 34 PMKclq21ktaMDNWLLFDRHPLSATLVFPYLSLKNGYLAFEHFLALAANFTA-----......- 35 TIFe.......AGGGFVQDRSIYEDTGIFAKMHADKGTMSKVDYKTYTSLFEAMVMTPy.....F 36 PLKtqs21vgpLDKWVIVDRHQLSALVVFPLVLMRRGMLSFSDFFNLLGMFEA-----......- 37 PLKtqs21vgpLDKWVIVDRHQLSALVVFPLVLMRRGMLSFSDFFNLLGMFEA-----......- 38 PFRtna21sgrGTHWCVFDRHLLSPAVVFPLMHLKHGRLSFDHFFQLLSIFRA-----......- 39 PFRvla21vapLDCWILHDRHLLSASVVFPLMLLRSQLLSYSDFIQVLATFTA-----......- 40 PFRvla21vapLDCWILHDRHLLSASVVFPLMLLRSQLLSYSDFIQVLATFTA-----......- 41 ECFv.......PSRVNILERSIFSDRYVFAEAATALGYMDDPEWALYCKQHDWYTDKL......E 42 GVF........RTKGGILDRSIYGD-CVFASLLNCDGHISDEEYKIYIDLLDNMLEHS......- 43 --R........LQNPDIMERSPMSATRVFCAVNGSRGVIPATALPGMAARGEAVMRTI......- 44 GMVt.......GARYVIQDRTVFEDANIFARNLYESGQMGERDWQTYRGLYEGVLPAL......- 45 QAI........RDHNSVSDRSIYED-ALFFKMNVDSGIADPTEFKIYDSLLENMMEQApgnp..S 46 NALahiln...TGQGVVLERTPHSD-FVFANAMRDKNYIGHEYFKHYYFVRKNALPQL......H 47 DALehlls...TGQGVVLERSIYSD-FVFLEAMYRQGFIRKQCVDHYNQVKKVTICEY......- 48 RILhlt15kffNNPVAIFDRHPVASNVCFPISRYVVGDMTPATLPGFLFAVSE-----......E 49 EAY........QADNNILDRSIFED-ELFLKLNYKNGNVTKTELDIYQELLANMLEELegmp..K 50 SFKd.......CKETVVVERCPWTSKNIFTSLMIENNLFDLSAIDTYNNLYER----L......S 51 DALehllt...TGQGVVLERSIFSD-FVFLEAMYNQGFIRKQCVDHYNEVKSVTICDY......- 52 SAL........TDDNNVLDRSIYED-ALFFQMNADIGRATPEEVDTYYELLHNMMSELdrmp..K 53 DTSdhflk...KGQPVIADYHIYKN-VIFAE-----RTLSPHQLEKYKKIYHLLTDDL......- 54 QLWqpgl....YRPEVVSDYLFDKD-FIFAAMN-----LRDAEFDLYQDLYGHLSPRL......- 55 --F........TEDIVFTERCPQVSHYVFAKMLSAKGTLTDEEMATYKNFYDKMN---......L 56 NCN........TINPTIFDRSIFED-WLFA----KHNIIRPAVFSYYNQLWNRLAKELvnk...H 57 HPGdgveaklaQQCHVITTRYYFSS------------LAYNCHTEADWEFVQRLNQSF......- 58 ECN........NKTPTIFDRSIFED-WLFA----KQNIHRPSIFTYYNHLWNGIVKELifk...H 59 HPGdgveaklaQQCHVITTRYYFSS------------LAYNCHTEADWEFVQRLNQSF......- 60 NNCn.......RKSLTIFDRSIFED-WLFAHANIDK----PSVFSYYDGLWQGVCKELiye...H 61 PYMvla22pplPGQTIIVDRHPIASLLCYPLARYLRGSFTLQTAMSLLAFIPK-----......I 62 PYValn21atpPDLILIFDRHPTASLLCYPLARYLTRCLPIESVLSLIALIPP-----......T 63 NVIkpalm...QGKWVVGDRHDMSS----QAYQGGGRQLDPHFMLTLKETVLG-----......N 64 QIN........KGVTCILDRYAFSG------------IAFSAAKGLDWEWCKSPDRGL......- 65 KISalm16nkePYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPA-----......D 66 NWLskik....DADLIILDRYYFSS------------IAYQGALGVDEQWIKMVNSYF......- 67 R--........---LGVVERCGGSP-EVLVVDRYKYSSLAYQGVGSGLEWVDAVNRKA......- 68 R--........--------YYGRAETVIFVRYLGGVLYLPERYARVLYRFFRSVL---......- 69 NVIkpalm...QGKWVVGDRHDMSS----QAYQGGGRQLDPHFMLTLKETVLG-----......N 70 YYRanq.....QRCNCILDRYAFSG------------IAFSAAKGLDWEWCKSPDRGL......- 71 EPT........RENLIELGRILKEKYGEDILIRLAVDKLRNCENIAIDGVRSMGEVDAi.....K 72 ALQ........SGYAVVMDRYYFSN------------IAYQSARGIDARLIREMNEKI......A 73 QAK........NLENIIFDRTLLED-PIFMKVNYDLNNVDQIDYNTYIEFYNNVVLENlkipenK 74 EPT........RENLIELGRLLKEKYGEDILIRLAIDKLRRCKNIAIDGVRSLGEVEAi.....K 75 KLA........DEDNVIIDRFVYSN-LVYAKKFKDYSILTERQLRFIEDKIKA-----......- 76 NLS........EDTLFILEASLLVE----------------------KGTYKN-----......- 77 KKGgileilntKSRKIITDRYLFSS-------------------IAYQGKLGYELNKN......F 78 ---........--HGCIIDEEDGEI-VIDVESLAAR--------IDFEGIVEGHLSHL......- 79 GQPvnip....SYDFKIHQSIESSS------------PVNPGDVIILEGILVLNDPRV......R 80 EKEl.......KDRNVVLDGHLSHL---------------------------------......- 150 160 170 180 190 | | | | | 1 VQADLIIYLRTSPEVAYERIRQRARSEES.....CVPL....KYLQELHELHEDWLIH......Q 2 VQADLIIYLRTSPEVAYERIRQRARSEES.....CVPL....KYLQELHELHEDWLIH......Q 3 LLLHGFIYLQASPQVCMERLYQRDREEEK.....GIEL....AYLQQLHSQHEDWFINkttklhF 4 VSVDLIVYLRTNPETCYQRLKKRCREEEK.....VIPL....EYLEAIHHLHEEWLIKg.....S 5 VSVDLIVYLRTNPETCYQRLKKRCREEEK.....VIPL....EYLEAIHHLHEEWLIKg.....S 6 ITLHGFIYLQASPQVCLKRLYQRAREEEK.....GIEL....AYLEQLHGQHEAWLIHkttklhF 7 LLLHGFIYLQASPQVCMERLYQRDREEEK.....GIEL....AYLQQLHSQHEDWFINkttklhF 8 VSVDLIVYLRTNPETCYQRLKKRCREEEK.....VIPL....EYLEAIHHLHEEWLIKg.....S 9 ITLHGFIYLQASPQVCLKRLYQRAREEEE.....GIEL....AYLEQLHGQHEAWLIHkttklhF 10 ITLHGFIYLQASPQVCLKRLYQRAREEEE.....GIEL....AYLEQLHGQHEAWLIHkttklhF 11 LLLHGFIYLQASPQVCMERLYQRDREEEK.....GIEL....AYLQQLHSQHEDWFINkttklhF 12 VSVDLIVYLRTTPEICYQRLKMRCREEEK.....VIPM....EYLHAIHRLYEEWLVNg.....S 13 LELDGIIYLQATPETCLHRIYLRGRNEEQ.....GIPL....EYLEKLHYKHESWLLHrtlktnF 14 LELDGIIYLRATPEKCLNRIYLRGRNEEQ.....GIPL....EYLEKLHYKHESWLLHrtlktsF 15 LELDGIIYLRATPEKCLNRIYIRGRDEEQ.....GIPL....EYLEKLHYKHESWLLHrtlktnF 16 HDGDVVVLLTLNSSEAHRRIQSRGRKEEK.....GITQ....NYLRQVAWAYHAVFCT......W 17 HDGDVVVLLTLNSSEAHRRIQSRGRKEEK.....GITQ....NYLRQVAWAYHAVFCT......W 18 SHGDNIILLNLNSQENLERVKRRNRKEEK.....CVSL....EHIRMLNSCYHAVYCA......W 19 IKIDGIIYLKTSPDICYKRMLNRARHEEN.....TVKI....DYLNLLHDKHEKWLSEn.....N 20 SQGDNIILLNLNSQENLKRVRKRNRKEEK.....SVSI....EHIRLLNNCYHAVYCA......W 21 SRGDNIILLNLNSQENLKRVKKRNRKEEK.....SVSI....EHIRLLNNCYHAVYCA......W 22 DPGDTIVWMKLNVEENMRRLKKRGRKHES.....GLDA....GYLKSVNDAYHAVYCA......W 23 PPGTNLVVCTVSLPSHLSRVSKRARPGE-.....TVNL....PFVMVLRNVYIMLINT......I 24 PPGTNLVVCTVSLPSHLSRVSKRARPGE-.....TVNL....PFVMVLRNVYIMLINT......I 25 PPGTNLVVCTVSLPSHLSRVSKRARPGE-.....TVNL....PFVMVLRNVYIMLINT......I 26 PPGTNLVVCTVSLPSHLSRVSKRARPGE-.....TVNL....PFVMVLRNVYIMLINT......I 27 PPGTNLVVCTVSLPSHLSRVSKRARPGE-.....TVNL....PFVMVLRNVYIMLINT......I 28 PPGTNLVVCTVSLPSHLSRVSKRARPGE-.....TVNL....PFVMVLRNVYIMLINT......I 29 NEGDIIVLIALDHGEAIRRIKTRKRPEEE.....TISL....TYVIRLHWCFVAVYNT......W 30 QKFDNVVLFKLHPKVAATRVKERGRNPEG.....VINH....TYLQLLNEVLDAIFCA......W 31 QKFDNVVLFKLHPKVAATRVKERGRNPEG.....VINH....TYLQLLNEVLDAIFCA......W 32 PPGTNLVVCTVSLPSHLSRVSKRARPGE-.....TVNL....PFVMVLRNVYIMLINT......I 33 PPGTNLVVCTVSLPSHLSRVSKRARPGE-.....TVNL....PFVMVLRNVYIMLINT......I 34 HEGDIIALLCMGEEDNLKMVKLRNRKGES.....GVTS....AHLKDLGQAFHACYCT......W 35 PHPDVLIYLEGDLENILNRIEQRGREMEL.....QTSR....SYWEEMHTRYENWISG......F 36 HPGEVIALMSVNVEENFTRLKKRGRVCER.....HIDR....DYIKEIKGSFNAAYCA......W 37 HPGEVIALMSVNVEENFTRLKKRGRVCER.....HIDR....DYIKEIKGSFNAAYCA......W 38 TEGDVVAILTLSSAESLRRVRARGRKNDG.....TVEQ....NYIRELAWAYHAVYCS......W 39 DPGDTIVWMKLNVEENMRRLKKRGRKHES.....GLDA....GYLKSVNDAYHAVYCA......W 40 DPGDTIVWMKLNVEENMRRLKKRGRKHES.....GLDA....GYLKSVNDAYHAVYCA......W 41 IQFDGIIYLRTIPESCKERINEKSITEKNyp...NISI....DYLKTLHEKHELWLTQ......C 42 QRPSLLVYLDCSIDEVERRIKNRNRSFEM.....NIPR....DYLEGLNRKYLKWYDE......Y 43 ATRPVFVYLELPPEECLRRMRRRDRTGEA.....GVGL....DYLRLLHERYEAWLSS......- 44 RVPDLLIHIDAGLPTLRRRIALRGRDYEQ.....AIPD....EYLAGLNRLYAGWIAA......F 45 KKPDLLIYIHVSLDTMLHRIQKRGRKFEQ.....LSTDpslkDYYARLLSYYEPWY--......- 46 FWPHLVVYLNTPTNKCLENIKRRGNTDEIa....TVDE....RYLKTIEESYKDSLRE......Y 47 LPPHVVVYVDVPVPEVQSRIQKKGNPHEM.....KITS....AYLQDIENAYKGTFLPemsek.C 48 PEGTNLIVCTVSLTNHLTRITNRSRSGE-.....IIDV....QFILVLRNVYIMLINT......I 49 KRPDLLIYIDVSFDKMLERIEKRGRSFEQvd...--GNpsleQYYHQVHGEYPTWYED......Y 50 YQVDHFIYIKVDSEMAFERIKKRDRFAEQ.....NISF....DYLKSLENKYATSLAT......- 51 LPPHLVIYIDVPVPEVQRRIQKKGDPHEM.....KITS....AYLQDIENAYKKTFLPemsek.C 52 KNPDLLVHIDVSYDTMLKRIQKRGRNYEQls...--YDptleDYYKRLLRYYKPWYAK......Y 53 PKPNFIIYIKASLPTLLHRIEKRGRPFEK.....KIET....SYLEQLISDYEVAIKQl.....Q 54 PTPDLVVYLRADPPELLRRIARRGRPFEH.....DMKA....AYLADLTGRYDDYFRT......Y 55 WKPDVHIFLKCPIDVCEQRLKRRSDSY--.....TIDT....EYMERLEKYYSIFN--......- 56 GVPNLYVILDGDWKLFEKRLFMRNRKVEIdnf..TKNQ....LYFQNLHRVYTGFMEA......V 57 PQPDWVIYLDLPVDLALQRLGDRQQLEDQaprecYEQR....EKLISVHRNYDRIFAH......Y 58 GIPALYVILEGDWELFEQRLFQRNRKVEIdnf..AKNK....DYFKNLYKIYGEFIKN......V 59 PQPDWVIYLDLPVDLALQRLGDRQQLEDQaprecYEQR....EKLISVHRNYDRIFAH......Y 60 GVPKLYVILDGDWELFKERIFKRNRKVEIdnf..SINE....TYFKRLLEMYKNYMVN......V 61 PHGTNLVLGKLSGGETTQRLYERGRPGE-.....VVDW....HMIECIHNIYDRLQNT......V 62 PPGTNLILGTAPAEDHLSRLVARGPPGE-.....LPDA....RMLRAIRYVYALLANT......V 63 FEPDLTIYLDIDPSVGLARARGRGELDRIe....QMDL....DFFHRTRARYLELVKD......- 64 PRPDLVIFLNVDPRIAATR---GQYGEER.....YEKI....EMQEKVLKNFQRLQKE......F 65 PP---------------------------.....----....----------------......- 66 PKPDMVILLDLPIEVAISRIKNDKFNFEE.....KIKS....--LAKVREKYLKLA--......- 67 PEAEILVYIDVPTEVALRRITARERR-EV.....FETP....EFLERVKSMYEEVL--......- 68 PTSPYMFYLEAEPEVCMERVARRSES-EM.....FENI....EDFRRVRERAFRILKG......W 69 FEPDLTIYLDIDPSVGLARARGRGELDRIe....QMDL....DFFHRTRARYLELVKD......- 70 TRPDLVIFLNVDPRIAATR---GQYGEER.....YEKI....EMQEKVLKNLQRLQKE......F 71 RMGGIVVYIEAKPEIRFERLRRRGSSKDR.....GIKS....--LEDLLK-FDEWE--......- 72 PKPDLTILLDVEPEIALERVRKRGKLSP-.....FEKL....DYLRKVRKCFLENA--......- 73 LSFDIVIYLRVSTKTAISRIKKRGRSEEP.....LIGD....EYWETLNKNYEEFYKQ......N 74 RMGGIIIYIEARAEVRFERLRKRCSEKDR.....GIKT....--LQDLLR-FDEWE--......- 75 --KAKVVYLHADPSVIKKRLRVRGDE---.....YIEG....KDIDSILELYREVMSN......- 76 --YDKLIVVYAPYEVCKERAIKRGMSEED.....FERR....------------WKKQmp....I 77 PLPEKVFFIETDPNIAYERIQKNRTQSDLfe...LEKY....KTFEQIALKYLKIFKK......L 78 LKPDVAIVLRCNPAVLRERLKGRNWSEE-.....----....KLLENLEAEMLDVILV......E 79 DLMNMKIFVDTDADVRLSRRIQRDTVER-.....GRN-....--IQNVLEQYTKFVKP......- 80 MPVDLVVVLRAHPRIIGERLRERGYSKEKig...-ENV....----------EAELVD......A 200 210 220 230 240 250 | | | | | | 1 RRPQSC....KVLVLDAD..LNLENIGTEYQRSESSIFDAISSNQQPSPVLVSPSKRQRVAR 2 RRPQSC....KVLVLDAD..LNLENIGTEYQRSESSIFDAISSNQQPSPVLVSPSKRQRVA- 3 EALQHV....PVLVLDVT..EDFSENAARQEELMGQV------------------------- 4 LFPMAA....PVLVIEAD..HHMERM--------------LELFEQNRDRILTPENRKH--- 5 LFPMAA....PVLVIEAD..HHMERM--------------LELFEQNRDRILTPENRKH--- 6 EALMNI....PVLVLDVN..DDFSEEVTKQEDLMREV------------------------- 7 EALQHV....PVLVLDVT..EDFSENAARQEELMGQV------------------------- 8 LFPMAA....PVLVIEAD..HHMERM--------------LELFEQNRDRILTPENRKH--- 9 EALMNI....PVLVLDVN..DDFSEEVTKQEDLMREV------------------------- 10 EALMNI....PVLVLDVN..DDFSEEVTKQEDLMREV------------------------- 11 EALQHV....PVLVLDVT..EDFSENAARQEELMGQV------------------------- 12 LFPAAA....PVLVIEAD..HNLEKM--------------LELFEQNRARILTPENWKHW-- 13 DYLQEV....PILTLDVN..EDFKDKYESLVEKVKEFL------------------------ 14 DYLQEV....PVLTLDVN..EDFKDKHESLVEKVKEFL------------------------ 15 EYLQEV....PILTLDVN..LDFKDKEESLVEKVKEFL------------------------ 16 VMMQYLt...PEQMVQLC..VQTVSIE----------------------------------- 17 VMMQYLt...PEQMVQLC..VQTVSIE----------------------------------- 18 LLVQNFt...PEEIVEVC..FNTKQI-TDLRSSKPSFLEKHVSIED---------------- 19 EHEFKV....PVLEINGD..GDFIDDSNRQSSILSNIYDFI--------------------- 20 LLVQNFt...PEEIVEVC..FNAKHI-TDLSSSKPSFLAKHVSTE----------------- 21 LLVQNFt...PEEIVEVC..FNAKHI-TDLSSSKPSFLAKHVSTE----------------- 22 LLTQYFa...PEDIVKVC..AGLTTIT----------------------------------- 23 IFLK--....--------..------------------------------------------ 24 IFLK--....--------..------------------------------------------ 25 IFLK--....--------..------------------------------------------ 26 IFLK--....--------..------------------------------------------ 27 IFLK--....--------..------------------------------------------ 28 IFLK--....--------..------------------------------------------ 29 RLLQYFt...AREATEVC..LDIKT------------------------------------- 30 ELLAIVp...PEVIVDAM..LSQTSVKTVF-------------------------------- 31 ELLAIVp...PEVIVDAM..LSQTSVKTVF-------------------------------- 32 IFLK--....--------..------------------------------------------ 33 IFLK--....--------..------------------------------------------ 34 LLLKYLs...PEDMVSVCc.CDVTLNDICIMRSM---------------------------- 35 ---NAC....PVLKLRIEd.YDLLNDENSIENIVDQIASVIHD------------------- 36 LFLQYF....S-------..------------------------------------------ 37 LFLQYF....S-------..------------------------------------------ 38 IMLQYIt...VEQMVQLC..VQTTNIP----------------------------------- 39 LLTQYFa...PEDIVKVC..AGLTTIT----------------------------------- 40 LLTQYFa...PEDIVKVC..AGLTTIT----------------------------------- 41 ---KKV....PVLIIDGE..EDFIFDPCAKKKLINEVTEFI--------------------- 42 NLSSKI....KFSYDNIN..IFSEEDRNKVISL----------------------------- 43 ----AE....DVERVDAS..RSREEIVDRVIEI----------------------------- 44 ---DLC....PVVRVDGDa.LDFVHDPQAFEWVCGR-------------------------- 45 EKYNAS....PKMMIDGDk.YDFVANEDARRKVINAIDQKLIDI------------------ 46 R--NHS....KILAYDWTkpGDTDAVVEDIERLDLDFFEWHS-------------------- 47 EVLQYS....AWEAQDAE..KVVEDIE----------------------------------- 48 RYLQAK....SDWLIDW-..------------------------------------------ 49 ---KVS....PKMKIDGNs.LDFVQNPQDLATVLKMID------------------------ 50 --LSPS....TVTIIDGS..NTIEEVEFDVKTAINNF------------------------- 51 EVLQYS....AREAQDSK..KVVEDIE----------------------------------- 52 ---DYS....PKMTIDGDk.LDFMASEEDRQEVLNQIVAKLKEMGK---------------- 53 EADPEL....TVLTVDGDs.KDFVLNKSDFERIAAHV------------------------- 54 ----AH....PHLILEAGn.YDFVANEADQQAIFDQIDAA---------------------- 55 KYTNST....PIKFIDAS..KNEDEVEEDFMNQVKDF------------------------- 56 CNDFGI....NYCIIDAK..LPIVTIIKMILE------------------------------ 57 ----QG....QLCRLDAS..LPVEQLHQAIITKVEE-------------------------- 58 CYDFGI....SHCIVNAN..QSVESITKQVLEVL---------------------------- 59 ----QG....QLCRLDAS..LPVEQLHQAIITKVEE-------------------------- 60 CKDFGI....NYVVLDAN..NSVEQNVDEVTKILQK-------------------------- 61 TYIQQG....NNWRDDW-..------------------------------------------ 62 KYLQSG....GSWRADL-..------------------------------------------ 63 ----NP....KAVVINAE..QSIELVQADIESAVKN-------------------------- 64 -REEGL....EFITLDAS..SSLEDVHSQIVDLVSNV------------------------- 65 ------....--------..------------------------------------------ 66 ---KEY....NFYVVDAS..KDKNEVLEQAIKII---------------------------- 67 RLARAR....GVKVIRVE..GVRGGVERGIEDVQGEIAE----------------------- 68 ------....--KFINTN..RPIEETRREIERILSEL------------------------- 69 ----NP....KAVVINAE..QSIELVQADIESAVKN-------------------------- 70 -REEGL....EFITLDASs.YALEDVDSQIVDLVSNV------------------------- 71 EKLYET....TKIKEKAD..IVIV-------------------------------------- 72 ----DE....TTVVVDAS..KPLEEVKEEVRKVIESFL------------------------ 73 V--YNF....PFFVVDAE..LDVKAQIELIMNKLNSI------------------------- 74 ERLYST....TNIKEKAD..FVILNE------------------------------------ 75 ------....--------..------------------------------------------ 76 EEKVKY....ADYVIDNS..GSIEETYKQVKKVYE--------------------------- 77 E--KKI....NVI-----..------------------------------------------ 78 ALEHAS....EVYEIDTTe.MSLEEVIEAVEAIIR--------------------------- 79 ------....--------..------------------------------------------ 80 ILIEAIdeheNVIEVDTTn.KTPEEIVEEIIGLIK---------------------------