; SAM: prettyalign v3.2 (July 31, 2000) compiled 08/11/00_16:27:51 ; (c) 1992-2000 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequences correspond to the following labels: ; 1 gi|7305281|ref|NP_038628.1|_164:450 ; 2 gi|3986757|gb|AAC84154.1|_164:450 ; 3 gi|4505253|ref|NP_002432.1|_165:451 ; 4 gi|3108220|gb|AAC62533.1|_165:451 ; 5 gi|5725250|emb|CAB52406.1|_185:468 ; 6 gi|3914066|sp|Q19272|MSH5_CAEEL_236:606 ; 7 gi|3831701|gb|AAC70065.1|_236:505 ; 8 gi|8515837|gb|AAF76200.1|_236:505 ; 9 gi|6320047|ref|NP_010127.1|_235:528 ; 10 gi|1582703|prf||2119252A_235:528 ; 11 gi|7522430|pir||T38256_135:417 ; 12 gi|6166561|sp|O13921|MSH1_SCHPO_296:578 ; 13 gi|172000|gb|AAA34801.1|_327:582 ; 14 gi|6321912|ref|NP_011988.1|_327:582 ; 15 gi|3914062|sp|O65607|MSH3_ARATH_353:725 ; 16 gi|3319876|emb|CAA07684.1|_370:712 ; 17 gi|7269404|emb|CAB81364.1|_353:725 ; 18 gi|1076927|pir||S22569_261:572 ; 19 gi|135075|sp|P26359|SWI4_SCHPO_353:664 ; 20 gi|6319935|ref|NP_010016.1|_398:725 ; 21 gi|448278|prf||1916402A_397:724 ; 22 gi|118951|sp|P20585|MSH3_HUMAN_485:798 ; 23 gi|4505249|ref|NP_002430.1|_476:789 ; 24 gi|387849|gb|AAB60711.1|_443:753 ; 25 gi|1083296|pir||JC4019_478:788 ; 26 gi|400971|sp|P13705|MSH3_MOUSE_443:753 ; 27 gi|110917|pir||A32495_443:753 ; 28 gi|7387924|sp|Q9Z6W5|MUTS_CHLPN_220:532 ; 29 gi|7189834|gb|AAF38705.1|_220:532 ; 30 gi|7190210|gb|AAF39048.1|_214:526 ; 31 gi|7387913|sp|O84797|MUTS_CHLTR_214:526 ; 32 gi|6647605|sp|Q9ZDM9|MUTS_RICPR_242:553 ; 33 gi|8473172|sp|P56883|MUTS_RHIME_251:566 ; 34 gi|6093453|sp|O83348|MUTS_TREPA_228:530 ; 35 gi|7448108|pir||S74860_287:595 ; 36 gi|7404405|sp|P73769|MUTS_SYNY3_253:561 ; 37 gi|123080|sp|P10564|HEXA_STRPN_211:510 ; 38 gi|7328284|emb|CAB82466.1|_202:419 ; 39 gi|7404403|sp|P49849|MUTS_BACSU_223:512 ; 40 gi|1002520|gb|AAB19235.1|_217:506 ; 41 gi|9106782|gb|AAF84525.1|AE003995_7_258:565 ; 42 gi|9654962|gb|AAF93703.1|_222:531 ; 43 gi|79102|pir||A28668_219:524 ; 44 gi|417330|sp|P10339|MUTS_SALTY_219:525 ; 45 gi|1592569|gb|AAB97931.1|_217:524 ; 46 gi|4887554|emb|CAB43497.1|_217:524 ; 47 gi|127556|sp|P23909|MUTS_ECOLI_217:524 ; 48 gi|1171081|sp|P44834|MUTS_HAEIN_218:526 ; 49 gi|7108493|gb|AAF36440.1|AF126491_1_214:523 ; 50 gi|7229490|gb|AAF42850.1|_214:523 ; 51 gi|127555|sp|P27345|MUTS_AZOVI_216:523 ; 52 gi|7243293|dbj|BAA92687.1|_39:229 ; 53 gi|7227419|gb|AAF42468.1|_217:518 ; 54 gi|7379009|emb|CAB83555.1|_217:518 ; 55 gi|6226653|sp|P74926|MUTS_THEMA_211:501 ; 56 gi|1619909|gb|AAB16999.1|_211:501 ; 57 gi|3024198|sp|P70755|MUTS_AQUPY_222:518 ; 58 gi|3914079|sp|O66652|MUTS_AQUAE_222:518 ; 59 gi|7387928|sp|Q9ZIX6|MUTS_THECA_209:506 ; 60 gi|2145507|pir||S62790_211:507 ; 61 gi|2497996|sp|Q56239|MUTS_THETH_212:508 ; 62 gi|1871501|dbj|BAA09880.1|_212:508 ; 63 gi|2497995|sp|Q56215|MUTS_THEAQ_203:500 ; 64 T0116-201-500 ; 65 gi|6320302|ref|NP_010382.1|_563:877 ; 66 gi|1588283|prf||2208298A_563:877 ; 67 gi|7492209|pir||T41262_618:924 ; 68 gi|7012942|gb|AAF35250.1|AF227632_1_1:276 ; 69 gi|6226648|sp|O04716|MSH6_ARATH_641:977 ; 70 gi|2104549|gb|AAB57798.1|_654:1015 ; 71 gi|1082386|pir||A56742_597:955 ; 72 gi|7512474|pir||JC5839_665:1023 ; 73 gi|7512473|pir||JC5840_665:1023 ; 74 gi|4504191|ref|NP_000170.1|_665:1023 ; 75 gi|1709123|sp|P52701|MSH6_HUMAN_665:1023 ; 76 gi|6754744|ref|NP_034960.1|_662:1021 ; 77 gi|2506881|sp|P54276|MSH6_MOUSE_662:1021 ; 78 gi|7294307|gb|AAF49656.1|_515:858 ; 79 gi|7331984|gb|AAF60672.1|_1110:1457 ; 80 gi|6224917|gb|AAF06013.1|AF193018_1_504:731 ; 81 gi|9294039|dbj|BAB01996.1|_504:731 ; 82 gi|9558057|emb|CAC00183.1|_134:238 ; 83 gi|4775578|emb|CAB42555.1|_609:822 ; 84 gi|4775580|emb|CAB42556.1|_302:515 ; 85 gi|9864530|gb|AAG00261.1|_293:603 ; 86 gi|1174416|sp|P43248|MSH2_DROME_246:566 ; 87 gi|7287834|gb|AAF44872.1|AE003406_77_250:570 ; 88 gi|7298155|gb|AAF53392.1|_250:507 ; 89 gi|172002|gb|AAA34802.1|_247:589 ; 90 gi|6324482|ref|NP_014551.1|_247:589 ; 91 gi|3914053|sp|O13396|MSH2_NEUCR_249:561 ; 92 gi|7522263|pir||T39832_265:579 ; 93 gi|4151103|emb|CAA07342.1|_266:586 ; 94 gi|1000875|gb|AAB59568.1|_262:377 ; 95 gi|1000877|gb|AAB59569.1|_262:423 ; 96 gi|1000879|gb|AAB59570.1|_262:482 ; 97 gi|1000883|gb|AAB59571.1|_262:529 ; 98 gi|2135744|pir||I37550_264:575 ; 99 gi|4557761|ref|NP_000242.1|_264:575 ; 100 gi|7448104|pir||I64827_264:575 ; 101 gi|726086|gb|AAA75027.1|_263:575 ; 102 gi|6678938|ref|NP_032654.1|_263:575 ; 103 gi|1709122|sp|P54275|MSH2_RAT_264:575 ; 104 gi|1079288|pir||S53609_262:573 ; 105 gi|4775576|emb|CAB42554.1|_250:572 ; 106 gi|3914056|sp|O24617|MSH2_ARATH_248:571 ; 107 gi|4139230|gb|AAD04176.1|_248:571 ; 108 gi|3886083|gb|AAC78226.1|_259:546 ; 109 gi|4505251|ref|NP_002431.1|_262:584 ; 110 gi|4336728|gb|AAD17920.1|_262:584 ; 111 gi|6321109|ref|NP_011187.1|_223:542 ; 112 gi|730066|sp|P40965|MSH4_YEAST_223:542 ; 113 gi|7493777|pir||T18246_144:464 ; 114 gi|5815430|gb|AAD52669.1|AF178755_1_159:495 ; 115 gi|3914075|sp|O51737|MUTS_BORBU_213:516 10 20 30 40 | | | | 1 --ILFLSSIIPFDCVLTVRALGGLLKFLSRR......RIGVeledydvgVPILG..FKKFVL... 2 --ILFLSSIIPFDCVLTVRALGGLLKFLSRR......RIGVeledydvgVPILG..FKKFVL... 3 --ILFLSSIIPFDCLLTVRALGGLLKFLGRR......RIGVeledynvsVPILG..FKKFML... 4 --ILFLSSIIPFDCLLTVRALGGLLKFLGRR......RIGVeledynvsVPILG..FKKFML... 5 -----RFTPIPLLIPSQVRALGGLLKFLGRR......RIGVeledynvsVPILG..FKKFML... 6 ---------------NMIRSFGALLLFLDET......RMGVtddplsvtSPIKS..IKTFTL... 7 ---------------NMIRSFGALLLFLDET......RMGVtddplsvtSPIKS..IKTFTL... 8 ---------------NMIRSFGALLLFLDET......RMGVtddplsvtSPIKS..IKTFTL... 9 -------------------------------......----........--IHG..IRYIDI... 10 -------------------------------......----........--IHG..IRYIDI... 11 ---EIDPSFIKYCTKLEVTAGCTLISYIADRl.....QNSH........PNIQP..PIRVSL... 12 ---EIDPSFIKYCTKLEVTAGCTLISYIADRl.....QNSH........PNIQP..PIRVSL... 13 --------------QKELAALRNTLIYVSNH......LPDF........SINFQi.PQRQLA... 14 --------------QKELAALRNTLIYVSNH......LPDF........SINFQi.PQRQLA... 15 -MSCLTVHTIMNMPHLTVQALALTFCHLKQF......GFER........ILYQGasFRSLSS... 16 -MSCLTVHTIMNMPHLTVQALALTFCHLKQF......GFER........ILYQGasFRSLSS... 17 -MSCLTVQTIMNMPHLTVQALALTFCHLKQF......GFER........ILYQGasFRSLSS... 18 --IELHMEKVKSLHSLSIICLDMAISYLMEF......SLED........LFVASnfYQPFDS... 19 --IELHMEKVKSLHSLSIICLDMAISYLMEF......SLED........LFVASnfYQPFDS... 20 --AIKVMNEKIQLSPSLIRLVSKLYSHMVEY......NNEQ........VMLIPsiYSPFAS... 21 --AIKVMNEKIQLSPSLIRLVSKLYSHMVEY......NNEQ........VMLIPsiYSPFAS... 22 --GSQIISGIVNLEKPVICSLAAIIKYLKEFn.....LEKM........LSKPEn.FKQLSS... 23 --GSQIISGIVNLEKPVICSLAAIIKYLKEFn.....LEKM........LSKPEn.FKQLSS... 24 --GSQSLSGVINLEKPVICALAAVIRYLKEFn.....LEKM........LSKPEs.FKQLSS... 25 --GSQSLSGVINLEKPVICALAAVIRYLKEFn.....LEKM........LSKPEs.FKQLSS... 26 --GSQSLSGVINLEKPVICALAAVIRYLKEFn.....LEKM........LSKPEs.FKQLSS... 27 --GSQSLSGVINLEKPVICALAAVIRYLKEFn.....LEKM........LSKPEs.FKQLSS... 28 FQVASLDGFGLKGLVPAINAAGGLLSYIQDK......LLLP........TKHIAi.PQTRGK... 29 FQVASLDGFGLKGLVPAINAAGGLLSYIQDK......LLLP........TKHIAi.PQTRGK... 30 FQVSSLDGFGLQGLVPAINAAGALLSYIQDK......LLLP........ISHLSi.PKIYGQ... 31 FQVSSLDGFGLQGLVPAINAAGALLSYIQDK......LLLP........ISHLSi.PKIYGQ... 32 ----RDIKGIGEISNSQICAIGSILEYLSLT......QKQN........IPHLPi.PKIINF... 33 ---VGTLDGFGSFSRAELAAASAAVSYVEKT......QLQE........RPALGi.PERESA... 34 ----------LLPHSPDLAAAGALIAYLEET......TRHP........LSHVSa.ITRYHI... 35 ---KSLEGMGCEGLPLAIRAAGGLLEYIEDTq.....KAHV........VPIQP..LKTYGL... 36 ---KSLEGMGCEGLPLAIRAAGGLLEYIEDTq.....KAHV........VPIQP..LKTYGL... 37 -----------RLATVEQTASSKLLQYVHRT......QMRE........LNHLKp.VIRYEI... 38 ----EIYSVNQTEHKLMYQATQLLLDYIHHT......QKRD........LSHIEd.VVQYAA... 39 -----------------------LYTYLKRT......QKRS........LDHLQp.VQVYEL... 40 -----------------------LYTYLKRT......QKRS........LDHLQp.VQVYEL... 41 --LHDLSGFGIENNPQATAAAGALLGYIEET......QKQR........LPHLTs.ITMETV... 42 FGTRDLVGFGVEQAKLGLCAAGCLIQYVKDT......QRTA........LPHIRs.LTWDRQ... 43 FGTRDLVGFGVENASRGLCAAGCLLQYVKDT......QRTS........LPHIRs.ITMERQ... 44 FGTRDLVGFGVENASRGLCAAGCLLQYVKDT......QRTS........LPHIRs.ITMERQ... 45 FGTRDLVGFGVENAPRGLCAAGCLLQYAKDT......QRTT........LPHIRs.ITMERE... 46 FGTRDLVGFGVENAPRGLCAAGCLLQYAKDT......QRTT........LPHIRs.ITMERE... 47 FGTRDLVGFGVENAPRGLCAAGCLLQYAKDT......QRTT........LPHIRs.ITMERE... 48 -GTKDLRAFGVEKSPLGLSAAGCLLQYAKET......QRTA........LPHIQs.ISLIQN... 49 FGTQDLKGFGCQNLTLAIGAAGCLLAYAKET......QRTA........LPHLRs.LRHDRL... 50 FGTQDLKGFGCQNLTLAIGAAGCLLAYAKET......QRTA........LPHLRs.LRHDRL... 51 --TQDLKGFGCDGLGLAIGAAGCLLAYARET......QRTA........LPHLRg.LRHERL... 52 -------------------------------......----........-----..------... 53 ----RGFGLDGKEHAVAIGAAGALLNYIRLT......QNLM........PQHLDg.LSLETD... 54 ----RGFGLDGKEHAVAIGAAGALLNYIRLT......QNLM........PQHLDg.LSLETD... 55 -----------ELSPLALKALAALIKYVKYTm.....IAED........LNLKP..PLLISQ... 56 -----------ELSPLALKALAALIKYVKYTm.....IGED........LNLKP..PLLISQ... 57 -----------EDL---SLSLGAVYRYAKAT......QKSF........TPLIPk.PKPYVD... 58 --------------DTYSLPLGAVYKYAKTT......QKGY........TPLIPr.PKPYRD... 59 ---EAPFDPEGEAPLALSRARGALLAYARAT......QGGA........LSVRP..FRLYDP... 60 ---EAPFEPQGEGPLALRRAQGALLAYARAT......QGGA........LSVRP..FRLYDP... 61 ---EAPFEPQGEGPLALRRAQGALLAYARAT......QGGA........LSVRP..FRLYDP... 62 ---EAPFEPQGEGPLALRRAQGALLAYARAT......QGGA........LSVRP..FRLYDP... 63 --SEAPFEPEGEGPLALRRARGALLAYAQRT......QGGA........LSLQP..FRFYDP... 64 MLSEAPFEPEGEGPLALRRARGALLAYAQRT......QGGA........LSLQP..FRFYDP... 65 ---EVLKSYYDTGKKVGFSAFGGLLYYLKWLkl....DKNL........ISMKN..IKEYDFvks 66 ---EVLKSYYDTGKKVGFSAFGGLLYYLKWLkl....DKNL........ISMKN..IKEYDFvks 67 ------LKSYLSEKPLAISAFGALFWYLRQLkl....DKDM........CSMGN..FDEYDAsqq 68 -------------------------------......----........-----..------... 69 ----SELATEDKNGSLALSALGGAIYYLRQA......FLDEsll10fesLPYCD..FSNVNE... 70 ----SELATEDKNGSLALSALGGAIYYLRQA......FLDEsll10fesLPYCD..FSNVNE... 71 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli....DQEL........LSMAN..FEEYIPlds 72 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli....DQEL........LSMAN..FEEYIPlds 73 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli....DQEL........LSMAN..FEEYIPlds 74 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli....DQEL........LSMAN..FEEYIPlds 75 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli....DQEL........LSMAN..FEEYIPlds 76 -ESDSVGLTPGEESELALSALGGIVFYLKKCli....DQEL........LSMAN..FEEYFPlds 77 -ESDSVGLTPGEESELALSALGGIVFYLKKCli....DQEL........LSMAN..FEEYFPlds 78 ---DHLGLTPNDNYKLALKALGQCIFFIHKCkl....EPKV........LPMAR..YQLYVPpdq 79 ---SSILPKPSTDWQLALSAFGAIFWYLRDSli....DVDM........LSMRN..VTIYNSnsm 80 --SWNCAVDGLNECDVALSALGELINHLSRLk.....LEDV........LKHGDi.FPYQVY... 81 --SWNCAVDGLNECDVALSALGELINHLSRLk.....LEDV........LKHGDi.FPYQVY... 82 -------------------------------......----........-----..------... 83 ------------NQDVVICALGGLIGHLTRLm.....LHDA........LKNGEv.LPYHVY... 84 ------------NQDVVICALGGLIGHLTRLm.....LHDA........LKNGEv.LPYHVY... 85 -------RLALSNCPLASRAIEYLVSNIIDNf.....DATN........HRAFY..LKHTIP... 86 ---EDATGLKELQLQLASNALKTAIKYLDLVn.....DAGN........LGHYE..IKQLDL... 87 ---EDATGLKELQLQLASNALKTAIKYLDLVn.....DAGN........LGHYE..IKQLDL... 88 ---EDATGLKELQLQLASNALKTAIKYLDLVn.....DAGN........LGHYE..IKQLDL... 89 --DDLALSLPQKYSKLSMGACNALIGYLQLLs.....EQDQ........VGKYE..LVEHKL... 90 --DDLALSLPQKYSKLSMGACNALIGYLQLLs.....EQDQ........VGKYE..LVEHKL... 91 ---------PQTDLKLAMGSASALIKYLGILh.....DPSN........FGQYQ..LYQHDL... 92 ---------PELGLQLAMASCNALLRYLGPA......LLNPdme9rentSRKLH..LYHHNL... 93 ----------ELGLQLAMASCNALLRYLGPA......LLNPdme9rentSRKLH..LYHHNL... 94 ------------ENQVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LTTFDF... 95 ------------ENQVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LTTFDF... 96 ------------ENQVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LTTFDF... 97 ------------ENQVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LTTFDF... 98 --------------QVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LTTFDF... 99 --------------QVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LTTFDF... 100 --------------QVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LTTFDF... 101 -------------NQVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LATFDF... 102 -------------NQVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LATFDF... 103 --------------QVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LATFDF... 104 -------------KQVAMSALAAVMKYLELLs.....DESN........FGQFV..MTNFDL... 105 ----EPVRDLLSQFDYALGPLGALLSYAELLa.....DDTN........YGNYT..IEKYNL... 106 ----EPVRDLVSGFDLATPALGALLSFSELLs.....NEDN........YGNFT..IRRYDI... 107 ----EPVRDLVSGFDLATPALGALLSFSELLs.....NEDN........YGNFT..IRRYDI... 108 -------------------------------......----........--KYS..IFNYGT... 109 ---FSTVLMEVQSKYYCLAAVAALLKYVEFI......QNSV........YAPKSlkICFQGS... 110 ---FSTVLMEVQSKYYCLAAVAALLKYVEFI......QNSV........YAPKSlkICFQGS... 111 -------------KTFALCAASAAISYMEEIiskssrNLNA........FRKLR..IQFEGT... 112 -------------KTFALCAASAAISYMEEIiskssrNLNA........FRKLR..IQFEGT... 113 --NESTLGQVISNRKLSLAAANACIDYCVSTk.....MFRV........TNKIR..LKYCMC... 114 ---VSTVSEGCLRRTLALGALAVLLKYIHET......RCVF........FRVKSlrIKEMGV... 115 --ILGLSSLGFDEEKPYYISIFLIINHIKNN......LKNL........LSNIDk.IDINND... 50 60 70 80 90 | | | | | 1 .....T.HLVSIDQDTYSVLQIFKSESH.Psvy12kegLSLFGILNRCRC.KWGQKLLRLWFTRP 2 .....T.HLVSIDQDTYSVLQIFKSESH.Psvy12kegLSLFGILNRCRC.KWGQKLLRLWFTRP 3 .....T.HLVNIDQDTYSVLQIFKSESH.Psvy12kegLSLFGILNRCHC.KWGEKLLRLWFTRP 4 .....T.HLVNIDQDTYSVLQIFKSESH.Psvy12kegLSLFGILNRCHC.KWGEKLLRLWFTRP 5 .....T.HLVNIDQDTYSVLQIFKSESH.Psvy12kegLSLFGILNRCHC.KWGEKLLRLWFTRP 6 .....G.NLVEIDFNTIQALDILPKETE.Nkktfgqg.RSLYQLMDKCRS.TVGKKCLRKWFRNP 7 .....G.NLVEIDFNTIQALDILPKETE.Nkktfgqg.RSLYQLMDKCRS.TVGKKCLRKWFRNP 8 .....G.NLVEIDFNTIQALDILPKETE.Nkktfgqg.RSLYQLMDKCRS.TVGKKCLRKWFRNP 9 .....R.DRMVLDENTISALHIFPTAHK.Lghd10ngfFSVFELFNQVSS.DYARRILKSWLINP 10 .....R.DRMVLDENTISALHIFPTAHK.Lghd10ngfFSVFELFNQVSS.DYARRILKSWLINP 11 .....N.EYMIIGESAMKGLEIRSSLYQ.Nryt.....GSLLHAINKTVT.KSGSRLLTRRLCAP 12 .....N.EYMIIGESAMKGLEIRSSLYQ.Nryt.....GSLLHAINKTVT.KSGSRLLTRRLCAP 13 .....T.AIMQIDSRTSTALELHSTVRD.Nnkk.....GSLLSSIRRTVT.PSGTRLLSQWLSGP 14 .....T.AIMQIDSRTSTALELHSTVRD.Nnkk.....GSLLSSIRRTVT.PSGTRLLSQWLSGP 15 .....N.TEMTLSANTLQQLEVVKNNSD.Gses.....GSLFHNMNHTLT.VYGSRLLRHWVTHP 16 .....N.TEMTLSANTLQQLEVVKNNSD.Gses.....GSLFHNMNHTLT.VYGSRLLRHWVTHP 17 .....N.TEMTLSANTLQQLEVVKNNSD.Gses.....GSLFHNMNHTLT.VYGSRLLRHWVTHP 18 .....I.SSMVLSKQALEGLELFVNQTD.Htpv.....GSLFWVLDRTYT.RFGQRMLQRWLQKP 19 .....I.SSMVLSKQALEGLELFVNQTD.Htpv.....GSLFWVLDRTYT.RFGQRMLQRWLQKP 20 .....K.IHMLLDPNSLQSLDIFTHDGG.K........GSLFWLLDHTRT.SFGLRMLREWILKP 21 .....K.IHMLLDPNSLQSLDIFTHDGG.K........GSLFWLLDHTRT.SFGLRMLREWILKP 22 .....KmEFMTINGTTLRNLEILQNQTD.Mktk.....GSLLWVLDHTKT.SFGRRKLKKWVTQP 23 .....KmEFMTINGTTLRNLEILQNQTD.Mktk.....GSLLWVLDHTKT.SFGRRKLKKWVTQP 24 .....GmEFMRINGTTLRNLEILQNQTD.Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQP 25 .....GmEFMRINGTTLRNLEILQNQTD.Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQP 26 .....GmEFMRINGTTLRNLEMVQNQTD.Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQP 27 .....GmEFMRINGTTLRNLEMVQNQTD.Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQP 28 .....Q.QKLLIDTASQVNLELLAPLND.Pqgk.....NSLLRIMDHTST.PMGGRLLRQILISP 29 .....Q.QKLLIDTASQVNLELLAPLND.Pqgk.....NSLLRIMDHTST.PMGGRLLRQILISP 30 .....H.KHLLIDKASQTNLELLSAIHG.Ehgk.....GSLLQVMERTST.PMGGRLLRNTLVNP 31 .....Q.KHLLIDKASQTNLELLSPIHG.Ehgk.....GSLLQVMERTST.PMGGRLLRNTLINP 32 .....H.NYMTIDFSTRRNLEIVTNLQG.Nly......GSVLNTLNHTVT.TQGGRLLYHFLSSP 33 .....A.STLFIDPATRANLELAKTLSG.Srd......GSLLKSLDRTMT.SGGARLLAERLMSP 34 .....H.DFVEIDDATRKNLEILQNLHD.Stha.....HSLFETLNYTHT.AMGTRLLRYWLHHP 35 .....T.DFLVLDHQTRRNLEINQTVRD.Gsfh.....GSLLWALDRTST.TMGSRALRRWLLQP 36 .....T.DFLVLDHQTRRNLEINQTVRD.Gsfh.....GSLLWALDRTST.TMGSRALRRWLLQP 37 .....K.DFLQMDYATKASLDLVENARS.Gkkq.....GSLFWLLDETKT.AMGMRLLRSWIHRP 38 .....I.DYMKMDFYAKRNLELTESIRL.Kskk.....GTLLWLMDETKT.PMGARRLKQWIDRP 39 .....E.EAMKIDLYSKRNLELTETIRS.Knkk.....GSLLWLLDETKT.AMGGRLLKQWIDRP 40 .....E.EAMKIDLYSKRNLELTETIRS.Knkk.....GSLLWLLDETKT.AMGGRLLKQWIDRP 41 .....G.EAITMNAATRRHLELDTRVDG.Esr......HTLLGVLDSTVT.PMGGRLLRRWLHRP 42 .....D.QSVILDAATRRNLELTHNLAG.Gtd......NTLAEVLDHCAT.PMGSRMLKRWIHQP 43 .....Q.DSIIMDAATRRNLEITQNLAG.Gve......NTLAAVLDCTVT.PMGSRMLKRWLHMP 44 .....Q.DSIIMDAATRRNLEITQNLAG.Gve......NTLAAVLDCTVT.PMGSRMLKRWLHMP 45 .....Q.DSIIMDAATRRNLEITQNLAG.Gae......NTLASVLDCTVT.PMGSRMLKRWLHMP 46 .....Q.DSIIMDAATRRNLEITQNLAG.Gae......NTLASVLDCTVT.PMGSRMLKRWLHMP 47 .....Q.DSIIMDAATRRNLEITQNLAG.Gae......NTLASVLDCTVT.PMGSRMLKRWLHMP 48 .....Q.DCIQLDAATRRNLELTQNLAG.Gte......NTLASVLDKCVT.PMGSRLLKRWIHQP 49 .....D.DTVILDGASRRNLELDINLSG.Gre......NTLQSVVDRCQT.AMASRLMSRWLNRP 50 .....D.DTVILDGASRRNLELDINLSG.Gre......NTLQSVVDRCQT.AMASRLMSRWLNRP 51 .....D.DTVILAGASRRNLELDVNLSG.Grd......NTLQSVIDRCQT.AMGSRLLGRWLNRP 52 .....-.---------------------.-........------------.-------------- 53 .....S.QYIGMDAATRRNLEITQTLSG.Kks......PTLMSTLDLCAT.HMGSRLLALWLHHP 54 .....S.QYIGMDAATRRNLEITQTLSG.Kks......PTLMSTLDLCAT.HMGSRLLALWLHHP 55 .....R.DYMILDSATVENLSLIPGDRG.Kn.......--LFDVLNNTET.PMGARLLKKWILHP 56 .....R.DYMILDSATVENLSWIPGDRG.Kn.......--LFDVLNNTET.PMGARLGKKWILHP 57 .....E.GYVKLDLKAVKGLEITESIEG.Rkd......LSLFKVVDRTLT.GMGRRRLRFRLLNP 58 .....E.GFVRLDIKAIKGLEILESLEG.Rkd......ISLFKVIDRTLT.GMGRRRLKFRLLSP 59 .....G.AIVRLPEASLKALEVFEPLRG.Q........DTLFGVLDETRT.APGRRLLQAWLRHP 60 .....G.AFVRLPEASLKALEVFEPLRG.Q........DTLFGVLDETRT.APGRRLLQAWLRHP 61 .....G.AFVRLPEASLKALEVFEPLRG.Q........DTLFGVLDETRT.APGRRLLQAWLRHP 62 .....G.AFVRLPEASLKALEVFEPLRG.Q........DTLFGVLDETRT.APGRRLLQAWLRHP 63 .....G.AFMRLPEATLRALEVFEPLRG.Q........DTLFSVLDETRT.APGRRLLQSWLRHP 64 .....G.AFMRLPEATLRALEVFEPLRG.Q........DTLFSVLDETRT.APGRRLLQSWLRHP 65 .....Q.HSMVLDGITLQNLEIFSNSFD.Gsdk.....GTLFKLFNRAIT.PMGKRMMKKWLMHP 66 .....Q.HSMVLDGITLQNLEIFSNSFD.Gsdk.....GTLFKLFNRAIT.PMGKRMMKKWLMHP 67 .....S.TSLLMNGQTLKNLEIFSNSFD.Ggse.....GTLFHLLCRCVT.PFGKRLFHTWLCHP 68 .....-.-----DTAALENLELLENTRT.Ggls.....GTLYAQLNHCVT.GFGKRLLKRWIAKP 69 .....K.QHMVLDAAALENLEIFENSRN.Ggys.....GTLYAQLNQCIT.ASGKRLLKTWLARP 70 .....K.QHMVLDAAALENLEIFENSRN.Ggys.....GTLYAQLNQCIT.ASGKRLLKTWLARP 71 18tkaY.QRMVLDAVTLNNLEIFLNGTN.Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAP 72 18tkaY.QRMVLDAVTLNNLEIFLNGTN.Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAP 73 18tkaY.QRMVLDAVTLNNLEIFLNGTN.Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAP 74 18tkaY.QRMVLDAVTLNNLEIFLNGTN.Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAP 75 18tkaY.QRMVLDAVTLNNLEIFLNGTN.Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAP 76 18tkaS.QRMVLDAVTLNNLEIFLNGTN.Gste.....GTLLERLDTCHT.PFGKRLLKQWLCAP 77 18tkaS.QRMVLDAVTLNNLEIFLNGTN.Gste.....GNLLERLDTCHT.PFGKRLLKQWLCAP 78 16tlrR.SHMVLDATTLSNLRII---GE.E........HSLLSTLDHCCT.KFGKRLLHHWLCAP 79 15dwnG.KNLILDGTALENLNIVPNGRD.Shl......TSLYYVINKCST.PFGRRLLRSWLLQP 80 .....R.GCLRIDGQTMVNLEIFNNSCD.Gvlq.....GPLNKYLENCVS.PTGKRLLRNWICHP 81 .....R.GCLRIDGQTMVNLEIFNNSCD.Ggps.....GTLYKYLDNCVS.PTGKRLLRNWICHP 82 .....-.-CLHXPGPTLRALDVFHSSVG.Lr.......GSLVGLLDHSVT.PCGSRCLRRWLTAP 83 .....K.TCLRMDGQTLVNLEIFINNFN.Ggss.....GTLYKHLNHCVT.ASGKRMLRRWICHP 84 .....K.TCLRMDGQTLVNLEIFINNFN.Ggss.....GTLYKHLNHCVT.ASGKRMLRRWICHP 85 .....S.TFMKLDTAAIQALHIIHQKPE.Argslp...TSVYSWLNRCVT.GMGSRMMRQWLLQP 86 .....N.RFVHLDSAAVAALNIMPKPGT.HpsmpsyrwQSVLGVLDHCRT.PQGHRLMGQWVKQP 87 .....N.RFVHLDSAAVAALNIMPKPGT.HpsmpsyrwQSVLGVLDHCRT.PQGHRLMGQWVKQP 88 .....N.RFVHLDSAAVAALNIMPKPGT.HpsmpsyrwQSVLGVLDHCRT.PQGHRLMGQWVKQP 89 .....K.EFMKLDASAIKALNLFPQGPQ.Npfg21gkvTSLFQLLNHCKT.NAGVRLLNEWLKQP 90 .....K.EFMKLDASAIKALNLFPQGPQ.Npfg21gkvTSLFQLLNHCKT.NAGVRLLNEWLKQP 91 .....A.QFMKLDAAALKALNLMPGARD.Gakn.....MSLYGLLNHCKT.PVGSRLLSQWLKQP 92 .....E.QYMRLDIAAVRSLNLLPPPNG.Nahkt....MSLYGLLNHCRT.AMGARNLRRWIVQP 93 .....E.QYMRLDIAAVRSLNLLPPPNG.Nahkt....MSLYGLLNHCRT.AMGARNLRRWIVQP 94 .....S.QYMKLDIAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQP 95 .....S.QYMKLDIAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQP 96 .....S.QYMKLDIAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQP 97 .....S.QYMKLDIAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQP 98 .....S.QYMKLDIAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQP 99 .....S.QYMKLDIAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQP 100 .....S.QYMKLDIAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQP 101 .....S.QYMKLDMAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.AQGQRLVNQWIKQP 102 .....S.QYMKLDMAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.AQGQRLVNQWIKQP 103 .....S.QYMKLDMAAVRALNLFQGSVE.Dttgs....QSLAAFLNKCKT.AQGQRLVSQWIKQP 104 .....S.QYMKLDNAAVGALNLFPGSAE.Dtsgt....QSLAGLLNKCKT.PQGQRLVNQWIKQP 105 .....N.CYMRLDSAAVRALNIAEGKTDv-nkn.....FSLFGLMNRTCTvGMGKRLLNRWLKQP 106 .....G.GFMRLDSAAMRALNVMESKTD.Ankn.....FSLFGLMNRTCTaGMGKRLLHMWLKQP 107 .....G.GFMRLDSAAMRALNVMESKTD.Ankn.....FSLFGLMNRTCTaGMGKRLLHMWLKQP 108 .....H.GNMLIDSCAVEALELFQLNYN.Yleksnn..LTLYNVLNKCKT.LPGEKLLRDWLSRP 109 .....E.QTAMIDSSSAQNLELLINNQD.Yrnn.....HTLFGVLNYTKT.PGGSRRLRSNILEP 110 .....E.QTAMIDSSSAQNLELLINNQD.Yrnn.....HTLFGVLNYTKT.PGGSRRLRSNILEP 111 .....E.NTMLIDSKTVRGLELVENKLD.Kng......ISLWKFLDTTST.KMGQRSLRNSILQP 112 .....E.NTMLIDSKTVRGLELVENKLD.Kng......ISLWKFLDTTST.KMGQRSLRNSILQP 113 .....E.NTMLIDTCTVRDLELVDSLSE.Tg.......TTLYSFLNCCLT.KMGMRILRTSILQP 114 .....N.DTCMIDFVSWESLEIVDADDA.Skar10kqkRTLMSVLNHTVT.TNGYRLLRSSVLQP 115 .....S.SYMFLDDVTQVNLELVKNNND.Fssq.....YSLYSVLNDCKT.AMGKRLLREFILNP 100 110 120 130 140 | | | | | 1 TRELRELNSRLDVIQFFLmp.....Q........NLDMAQMLH...RLLSHIKNVPLILKRMK.. 2 TRELRELNSRLDVIQFFLmp.....Q........NLDMAQMLH...RLLSHIKNVPLILKRMK.. 3 THDLGELSSRLDVIQFFLlp.....Q........NLDMAQMLH...RLLGHIKNVPLILKRMK.. 4 THDLGELSSRLDVIQFFLlp.....Q........NLDMAQMLH...RLLGHIKNVPLILKRMK.. 5 THDLGELSSRLDVIQFFLlp.....Q........NLDMAQMLH...RLLGHIKNVPLILKRMK.. 6 TTDRDDLVSRQKCVHYFKqviifkvE........YRNLWEIFL...NHSKFSPDSEYLSEKIFlk 7 TTDRDDLVSRQKCVHYFKqd.....W........NAEVTAKLS...SILGRVKALNSVFQKFQ.. 8 TTDRDDLVSRQKCVHYFKqd.....W........NAEVTAKLS...SILGRVKALNSVFQKFQ.. 9 LTNKKRIETRYSIIRTLLdk.....Q........NAIIFSDLS...QSIKRCPDAFGFINQLR.. 10 LTNKKRIETRYSIIRTLLdk.....Q........NAIIFSDLS...QSIKRCPDAFGFINQLR.. 11 STNIVEINNRLDLVEKFK.......L........LPELCSKVI...NLLKKSNDTHRILQHLL.. 12 STNIVEINNRLDLVEKFK.......L........LPELCSKVI...NLLKKSNDTHRILQHLL.. 13 SLDLKEIKKRQKIVAFFK.......D........NRDITENLR...TMLKKVNDLSRILQKFS.. 14 SLDLKEIKKRQKIVAFFK.......D........NRDITETLR...TMLKKVNDLSRILQKFS.. 15 LCDRNLISARLDAVSEIS.......Acmg27speFYLVLSSVL...TAMSRSSDIQRGITRIF.. 16 LCDRNLISARLDAVSEIS.......Acmg27speFYLVLSSVL...TAMSRSSDIQRGITRIF.. 17 LCDRNLISARLDAVSEIS.......Acmg27speFYLVLSSVL...TAMSRSSDIQRGITRIF.. 18 LVDKENIIERLDAVEELAf......N........SNSQVQAIR...KMLYRLPDLEKGLSRIYyq 19 LVDKENIIERLDAVEELAf......N........SNSQVQAIR...KMLYRLPDLEKGLSRIYyq 20 LVDVHQIEERLDAIECITsei....N........NSIFFESLN...QMLNHTPDLLRTLNRIM.. 21 LVDVHQIEERLDAIECITsei....N........NSIFFESLN...QMLNHTPDLLRTLNRIM.. 22 LLKLREINARLDAVSEVLh......S........ESSVFGQIE...NHLRKLPDIGRGLCSIY.. 23 LLKLREINARLDAVSEVLh......S........ESSVFGQIE...NHLRKLPDIERGLCSIY.. 24 LLKLREINARLDAVSDVLh......S........ESSVFEQIE...NLLRKLPDVERGLCSIY.. 25 LLKLREINARLDAVSDVLh......S........ESSVFEQIE...NLLRKLPDVERGLCSIY.. 26 LLKLREINARLDAVSDVLh......S........ESSVFEQIE...NLLRKLPDVERGLCSIY.. 27 LLKLREINARLDAVSDVLh......S........ESSVFEQIE...NLLRKLPDVERGLCSIY.. 28 FYNPKEILVRQDAVEFFL.......R........QVTLRKNIK...TYLCQVRDIERLMTKVT.. 29 FYNPKEILVRQDAVEFFL.......R........QVTLRKNIK...TYLCQVRDIERLMTKVT.. 30 FYDLKEITLRQDSVEFFL.......K........QEPLRKTLK...RHLSCVRDLERLATKIS.. 31 FYDLKEITLRQDSVEFFL.......Q........QADLRKILK...RQLSCVRDLERLATKIS.. 32 LTNIAKINHRLNITEFFY.......S........NLGIVTRIR...ELLKNTSDIERCLTRIT.. 33 LTDPERINQRLDSIEVLA.......D........QPRFTTDVR...DALRRAPDMPRALSRLA.. 34 LRSQEEIQKRLSAVVFFH.......H........RPHILKTLR...ATLSCVRDVERLVARVA.. 35 LLDLKGIQARQDTIQELY.......H........HPALRQDLR...QLLRQIYDLERLTGRIG.. 36 LLDLKGIQARQDTIQELY.......H........HPALRQDLR...QLLRQIYDLERLTGRIG.. 37 LIDKERIVQRQEVVQVFL.......D........HFFERSDLT...DSLKGVYDIERLASRVS.. 38 LISKEQIEARLDIVDEFS.......A........HFIERDTLR...TYLNQVYDIERLVGRVS.. 39 LIRVNQIEERQEMVETLM.......S........HFFEREDLR...ERLKEVYDLERLAGRVA.. 40 LIRVNQIEERQEMVETLM.......S........HFFEREDLR...ERLKEVYDLERLAGRVA.. 41 LRLREVVRQRHAAVGSMI.......-........DRDLDNKLM...ETFRRLGDMERILTRVA.. 42 MRDNATLNQRLDAITELK.......-........ETALYGELH...PVLKQIGDIERILARLA.. 43 VRNTDILRERQQTIGAL-.......-........-QDTVSELQ...PVLRQVGDLERTPC---.. 44 VRNTDILRERQQTIGAL-.......-........-QDTVSELQ...PVLRQVGDLERTPC---.. 45 VRHTRVLLERQQTIGAL-.......-........-QDFTAELQ...PVLRQVGDLERILARLA.. 46 VRDTRVLLERQQTIGAL-.......-........-QDFTAELQ...PVLRQVGDLERILARLA.. 47 VRDTRVLLERQQTIGAL-.......-........-QDFTAGLQ...PVLRQVGDLERILARLA.. 48 VRDVEKLKQRQQSIAEIL.......-........NFDLVDELQ...PYLQLVGDMERILARVA.. 49 LRDRAVLEARQESIACLL.......E........-RYRFENLQ...PQLKEIGDLERILARIG.. 50 LRDRAVLEARQESIACLL.......E........-RYRFENLQ...PQLKEIGDLERILARIG.. 51 LRDRAVLEARQDTVACLL.......Q........DY-RFESLQ...PQLKEIGDVERILARIG.. 52 ------------------.......-........---IGVDVS...PVMIKVVDAAVQKARIG.. 53 LRNRAHIRARQEAVAAL-.......-........-ESQYKPLQ...CRLKSIADIERIAARIA.. 54 LRNRAHIRARQEAVAAL-.......-........-ESQYKPLQ...CRLKNIADIERIAARIA.. 55 LVDRKQIEERLKAVERLV.......N........DRVSLEEMR...NLLSNVRDVERIVSRVE.. 56 LVDRKQIEERLKAVERLV.......N........DRVSLEEMR...NLLSNVRDVERIVSRVE.. 57 FRSIERIRKVQEAVEELI.......N........KREVLNEIR...KTLEGMSDLERLVSRIS.. 58 FRSREKIERIQEGVQELK.......E........NREALLKIR...QILEGMADLERLVSKIS.. 59 LLERGPLEARLDRVERFV.......R........EGALREGVR...RLLFRLADLERLATRLE.. 60 LLERGPLEARLDRVERFV.......R........EGALREGVR...RLLFRLADLERLATRLE.. 61 LLERGPLEARLDRVERFV.......R........EGALREGVR...RLLFRLADLERLATRLE.. 62 LLERGPLEARLDRVERFV.......R........EGALREGVR...RLLFRLADLERLATRLE.. 63 LLDRGPLEARLDRVEGFV.......R........EGALREGVR...RLLYRLADLERLATRLE.. 64 LLDRGPLEARLDRVEGFV.......R........EGALREGVR...RLLYRLADLERLATRLE.. 65 LLRKNDIESRLDSVDSLL.......Q........DITLREQLE...ITFSKLPDLERMLARIH.. 66 LLRKNDIESRLDSVDSLL.......Q........DITLREQLE...ITFSKLPDLERMLARIH.. 67 LRSGTAINARLDVVELIA.......D........NPVIRDTIW...GFLHKLPDLERLISRVH.. 68 LYDCREILRRQSAVATFKg......V........GQDCAAQFR...KDLSRLPDMERLLARLFss 69 LYNTELIKERQDAVAILRg......E........NLPYSLEFR...KSLSRLPDMERLIARMFss 70 LYNTELIKERQDAVAILRg......E........NLPYSLEFR...KSLSRLPDMERLIARMFss 71 LCNHYAINDRLDAIEDLM.......V........VPDKISEVV...ELLKKLPDLERLLSKIHnv 72 LCNHYAINDRLDAIEDLM.......V........VPDKISEVV...ELLKKLPDLERLLSKIHnv 73 LCNHYAINDRLDAIEDLM.......V........VPDKISEVV...ELLKKLPDLERLLSKIHnv 74 LCNHYAINDRLDAIEDLM.......V........VPDKISEVV...ELLKKLPDLERLLSKIHnv 75 LCNHYAINDRLDAIEDLM.......V........VPDKISEVV...ELLKKLPDLERLLSKIHnv 76 LCSPSAISDRLDAVEDLM.......A........VPDKVTEVA...DLLKKLPDLERLLSKIHnv 77 LCSPSAISDRLDAVEDLM.......A........VPYKVTEVA...DLLKKLPDLERLLSKIHnv 78 SCDVSVIKERQDAIGELI.......R........MPTELQEVR...ALLAPMPDFERNLAQIHlf 79 TCDPKKLEQRQKAIKWLVsp.....D........ASSFMTTAT...ATLKKIPDLDRLLQKIHti 80 LKDVESINKRLDVVEEFT.......A........NSESMQITG...QYLHKLPDLERLLGRIKss 81 LKDVESINKRLDVVEEFT.......A........NSESMQITG...QYLHKLPDLERLLGRIKss 82 LCERASIVARQEVLAYLMvc.....K........DDXQVEDXL...HECARXGDXEAVVSKLX.. 83 LKDIDAINKRLDVVEGFI.......Q........NCGLGPTTL...GYLQKIPDLERLLGQV-.. 84 LKDIDAINKRLDVVEGFI.......Q........NCGLGPTTL...GYLQKIPDLERLLGQV-.. 85 LRNAEDINQRLSLVELMV.......E........DSILRDALLs..QVLRCCGDMDRLNRKLQ.. 86 LRSRNILNDRHNIVQCLL.......E........SPDTMETLSl..DYLKRIPDILMLTKKLM.. 87 LRSRNILNDRHNIVQCLL.......E........SPDTMETLSl..DYLKRIPDILMLTKKLM.. 88 LRSRNILNDRHNIVQCLL.......E........SPDTMETLSl..DYLKR------------.. 89 LTNIDEINKRHDLVDYLI.......D........QIELRQMLTs..EYLPMIPDIRRLTKKL-.. 90 LTNIDEINKRHDLVDYLI.......D........QIELRQMLTs..EYLPMIPDIRRLTKKL-.. 91 LMNAEEIEKRQQLVEAFA.......N........DTELRQSMQe..EHLRSIPDLYRLSKRFQ.. 92 LLDAKSIERRHDLVSALV.......E........DAEARQLLLdddHLLRSIPDIPKLCRRLT.. 93 LLDAKSIERRHDLVSALV.......E........DAEARQLLLdddHLLRSIPDIPKLCRRLT.. 94 LMDKNRIEERLNLVEAFV.......E........DAELRQTLQ...-----------------.. 95 LMDKNRIEERLNLVEAFV.......E........DAELRQTLQe..DLLRRFPDLNRLAKKFQ.. 96 LMDKNRIEERLNLVEAFV.......E........DAELRQTLQe..DLLRRFPDLNRLAKKFQ.. 97 LMDKNRIEERLNLVEAFV.......E........DAELRQTLQe..DLLRRFPDLNRLAKKFQ.. 98 LMDKNRIEERLNLVEAFV.......E........DAELRQTLQe..DLLRRFPDLNRLAKKFQ.. 99 LMDKNRIEERLNLVEAFV.......E........DAELRQTLQe..DLLRRFPDLNRLAKKFQ.. 100 LMDKNRIEERLNLVEAFV.......E........DAELRQTLQe..DLLRRFPDLNRLAKKFQ.. 101 LMDRNRIEERLNLVEAFV.......E........DSELRQSLQe..DLLRRFPDLNRLAKKFQ.. 102 LMDRNRIEERLNLVEAFV.......E........DSELRQSLQe..DLLRRFPDLNRLAKKFQ.. 103 LMDKNRIEERLNLVEAFV.......E........DSELRRALQe..DLLRRFPDLNRLAKKFQ.. 104 LMDKNRVEERLNLVEAFV.......M........DVELRQCLQe..DLLRRFPDLNRLAKKFQ.. 105 LLDVNEINNRLDMVQAFV.......E........DPELRQGLR...QQLKRISDIDRLTHSLR.. 106 LVDLNEIKTRLDIVQCFV.......E........EAGLRQDLR...QHLKRISDVERLLRSLE.. 107 LVDLNEIKTRLDIVQCFV.......E........EAGLRQDLR...QHLKRISDVERLLRSLE.. 108 LCQIDHINERLDIVEALF.......E........NQTIRQKLRd..SILARMPDCSQLARRL-.. 109 LVDIETINMRLDCVQELL.......Q........DEELFFGLQ...SVISRFLDTEQLLSVLVqi 110 LVDIETINMRLDCVQELL.......Q........DEELFFGLQ...SVISRFLDTEQLLSVLVqi 111 LTDRGSIEMRLEALEELK.......A........NDDLLQKLR...LEMKSLPDLDKLFSRLLci 112 LTDRGSIEMRLEALEELK.......A........NDDLLQKLR...LEMKSLPDLDKLFSRLLci 113 STHENSIILRSESLQELI.......N........DEDALISIR...SSLKHTCDLEKVFSTFLep 114 STDVYLIQSRQEAIEELI.......G........KPQLKDKLR...RTLSRAHELDRVIAMCIqt 115 ILNISEINTRLDHVEFFC.......K........NISLTVTLR...ETFINIWDIERIISRIQ.. 150 160 170 180 190 | | | | | 1 ......LSHTKVSDWQVLYK.TVYSALGLRDACRSLPQsiq12qefSDDLHHIASLIGKVVDFEE 2 ......LSHTKVSDWQVLYK.TVYSALGLRDACRSLPQsiq12qefSDDLHHIASLIGKVVDFEE 3 ......LSHTKVSDWQVLYK.TVYSALGLRDACRSLPQsiq12qefSDDLHHIASLIGKVVDFEG 4 ......LSHTKVSDWQVLYK.TVYSALGLRDACRSLPQsiq12qefSDDLHHIASLIGKVVDFEG 5 ......LSHTKVSDWQVLYK.TVYSALGLRDACRSLPQsiq12qefSDDLHHIASLIGKVVDFEG 6 k96kfqSGTAQLIHWECFVS.TVNALVEILNIIRQTPIske10sdlLREVSEIAVIAGSIINFAE 7 ......SGTAQLIHWECFVS.TVNALVEILNIIRQTPIske10sdlLREVSEIAVIAGSIINFAE 8 ......SGTAQLIHWECFVS.TVNALVEILNIIRQTPIske10sdlLREVSEIAVIAGSIINFAE 9 ......SGKSTLGTWSKVAS.FLEKGIAIFQLVSSLKLgsd16kvdISALKECLRKVETVIDFDT 10 ......SGKSTLGTWSKVAS.FLEKGIAIFQLVSSLKLgsd16kvdISALKECLRKVETVIDFDT 11 ......MGRGNSYDLLKMAD.NFSITKEIHSLLSPLESssa10llnMHPHDELKQLINNAVDENA 12 ......MGRGNSYDLLKMAD.NFSITKEIHSLLSPLESssa10llnMHPHDELKQLINNAVDENA 13 ......FGRGEALELIQMAR.SLEVSREIRKYLLNNTSlmk23knlIDDILKFLNEEELAKSQDA 14 ......FGRGEALELIQMAR.SLEVSREIRKYLLNNTSlmk23knlIDDILKFLNEEELAKSQDA 15 ......HRTAKATEVKIWPV.LCPLMYVPVSSSPGLRVlnf58pvvVDNAGKLLSALNKEAAVRG 16 ......HRTAKATEFIAVME.AILLAGKQIQRLGIKQDsem28pvvVDNAGKLLSALNKEAAVRG 17 ......HRTAKATEV-KIWP.VLCPLMYVPGSSSPGLRvln59pvvVDNAGKLLSALNKEAAVRG 18 r13afsKNSYSCFKSALLRR.LIQQLPSISSIIDHFLGmf......DQKEAENNNKVDMFKDIDN 19 r13afsKNSYSCFKSALLRR.LIQQLPSISSIIDHFLGmf......DQKEAENNNKVDMFKDIDN 20 ......YGTTSRKEVYFYLK.QITSFVDHFKMHQSYLSehf29llsTTQLPHFLTMINVSAVMEK 21 ......YGTTSRKEVYFYLK.QITSFVDHFKMHQSYLSehf29llsTTQLPHFLTMINVSAVMEK 22 ......HKKCSTQEFFLIVK.TLYHLKSEFQAIIPAVNshi14ileIPELLSPVEHYLKILNEQA 23 ......HKKCSTQEFFLIVK.TLYHLKSEFQAIIPAVNshi14ileIPELLSPVEHYLKILNEQA 24 ......HKKCSTQEFFLIVK.SLCQLKSELQALMPAVNshv11ralIVELLSPVEHYLKVLNGPA 25 ......HKKCSTQEFFLIVK.SLCQLKSELQALMPAVNshv11ralIVELLSPVEHYLKVLNGPA 26 ......HKKCSTQEFFLIVK.SLCQLKSELQALMPAVNshv11ralIVELLSPVEHYLKVLNGPA 27 ......HKKCSTQEFFLIVK.SLCQLKSELQALMPAVNshv11ralIVELLSPVEHYLKVLNGPA 28 ......TGLAGPRDIGTLRD.SFSAGAQIYEQLASATLpef10cslDTKLASLIALLSKSLNGDL 29 ......TGLAGPRDIGTLRD.SFSAGAQIYEQLASATLpef10cslDTKLASLIALLSKSLNGDL 30 ......TTLASPKDIGMLRD.SLLSCMHIAHDLQSYTLpef10cliSSSLKSLIEALSTDLLQEL 31 ......TSLATPKDIGTLRD.SLLSCTHIADNLQNCALpef10fliAPPLCSLIKTLSTELIQEL 32 ......MNRSSGRDLLSIKY.TLETAKTIKGLFSESYGlnl13ikpLSGDAELYNLIHMSIREDA 33 ......LGRGGPRDLGAIQA.GMRAAAAISALLSGAELsae11daiAALPGELLARLDATLAEEL 34 ......LEKAHGRDLLALKE.SLRAILTFRSLERESPFppd10egdTPVLQELYGLLEQSIKEDC 35 ......ANTASARDVYGLAS.SLVRLTDLAELAQEGHSpyl9lqtvPPELEELGKYVLAHIVENP 36 ......ANTASARDVYGLAS.SLVRLTDLAELAQEGHSpyl9lqtvPPELEELGKYVLAHIVENP 37 ......FGKTNPKDLLQLAT.TLSSVPRIRAILEGMEQptl9liaqLDAIPELESLISAAIAPEA 38 ......YGNVNARDLIQLKH.SISEIPNIKALLNSMNQntlvqvnqLEPLDDLLDILEQSLVEEP 39 ......FGNVNARDLIQLKE.SLKQVPGIKQLVASLAHdka9rakrIDPCGDVLELLEEALYENP 40 ......FGNVNARDLIQLKE.SLKQVPGIKQLVASLAHdka9rakrIDPCGDVLELLEEALYENP 41 ......LRSARPRDISTLRD.SLSLLPRLRELLNASDSprl9lyaeLGEHDSTASLLVKAVAEQP 42 ......LRSARPRDLARLRH.AMQQLPELHSVMSELKQphl9lrthAEPMDELCDLLERAIKENP 43 ......-ASGAAQPSARSRP.NASRLPAAAELHAQLET........VDSAPVQRCVKKWAISPSC 44 ......-ASGAAQPSARSRP.NASRLPAAAELHAQLETvds12rkkMGDFAELRDLLERAIIDAP 45 ......LRTARPRDLARMRH.AFQQLPELRAQLETVDSapv9lrekMGEFAELRDLLERAIIDTP 46 ......LRTARPRDLARMRH.AFQQLPELRAQLETVDSapv9lrekMGEFAELRDLLERAIIDTP 47 ......LRTARPRDLARMRH.AFQQLPELRAQLETVDSapv9lrekMGEFAELRDLLERAIIDTP 48 ......LRSARPRDLTRLRT.ALEQIPALRAIVQQKTPpfl9lfsqIADFSEQCDLLQRALIETP 49 ......LRNARPRDLARLRD.ALAALPDLQNAMTELEAphl9lattIGTYPELAELLAKAIIDNP 50 ......LRNARPRDLARLRD.ALAALPDLQNAMTELEAphl9lattIGTYPELAELLAKAIIDNP 51 ......LRNARPRDLARLRD.ALAALPQLQTALSPLEAphl9lagnIRTYPELAELLRRAIIDNP 52 ......LRNARPRDLARLRD.ALGALPELQNAMTELEAphl9laaiTGTYPELASLLERAIIDNP 53 ......VGNARPRDLAALRD.SLFALSEIELSAECSSLlgtlkav.FPENLSTAEQLRQAILPEP 54 ......VGNARPRDLASLRD.SLFELAQIDLSANGSSLletlkav.FPENLSTAEQLRQAILPEP 55 ......YNRSVPRDLVALRE.TLEIIPKLNEVLSTFGVfkk.....LAFPEGLVDLLRKAIEDDP 56 ......YNRSVPRDLVALRE.TLEIIPKLNEVLSTFGVfkk.....LAFPEGLVDLLRKAIEDDP 57 ......SNMASPRELIHLKN.SLRKAEELRKILSLLDSeif9iegsLLNLNKVADLIDKTLVDDP 58 ......SNMATPRELVYLKN.SLKKVEELRLLLLELKApif9ilqnFEDTKKIINDIEKTLVEDP 59 ......LSRASPRDLAALRRrSLEILPELEGLLGEEVG........LPDLSGLLEELRAALVEDP 60 ......LSRASPRDLAALRR.SLEILPELKGLLGEEVG........LPDLSGLLEELRAALVEDP 61 ......LSRASPRDLAALRR.SLEILPELKGLLGEEVG........LPDLSGLLEELRAALVEDP 62 ......LSRASPRDLAALRR.SLEILPELKGLLGEEVG........LPDLSGLLEELRAALVEDP 63 ......LGRASPKDLGALRR.SLQILPELRALLGEEVG........LPDLSPLKEELEAALVEDP 64 ......LGRASPKDLGALRR.SLQILPELRALLGEEVG........LPDLSPLKEELEAALVEDP 65 ......SRTIKVKDFEKVIT.AFETIIELQDSLKNNDL........KGDVSKYISSFPEGLVEAV 66 ......SRTIKVKDFEKVIT.AFETIIELQDSLKNNDL........KGDVSKYISSFPEGLVEAV 67 ......AGRSKPADFVRVLE.GFQRINSAFDQLREEFMeva14iqsAPNMKEELEAWTRAFNWQK 68 c17yedASKKLLQQFTSALC.GCQQMFHACSSISTLICseg15gkgLSNISSILDRFRDAFDWSD 69 i18yedTAKKQVQEFISTLR.GCETMAEACSSLRAILKhdt16gqsLPNISSSIKYFKDAFDWVE 70 i18yedTAKKQVQEFISTLR.GCETMAEACSSLRAILKhdt41gqsLPNISSSIKYFKDAFDWVE 71 g23ettYSKKKIIDFLSALE.GFKVMCKIIGIMEEVADgfk21egrFPDLTVELNRWDTAFDHEK 72 g23ettYSKKKIIDFLSALE.GFKVMCKIIGIMEEVADgfk21egrFPDLTVELNRWDTAFDHEK 73 g23ettYSKKKIIDFLSALE.GFKVMCKIIGIMEEVADgfk21egrFPDLTVELNRWDTAFDHEK 74 g23ettYSKKKIIDFLSALE.GFKVMCKIIGIMEEVADgfk21egrFPDLTVELNRWDTAFDHEK 75 g23ettYSKKKIIDFLSALE.GFKVMCKIIGIMEEVADgfk21egrFPDLTVELNRWDTAFDHEK 76 g23ettYSKKKIIDFLSALE.GFKVMCKVSGLLEEVAGgft21kgrFPDLTAELQRWDTAFDHEK 77 g23ettYSKKKIIDFLSALE.GFKVMCKVSGLLEEVAGgft21kgrFPDLTAELQRWDTAFDHEK 78 g24eklYNKQKLQGFMAVLK.GFNDLTKLPTMFHQCKTtll15ggsFPDLSKELQYFATAFDHDA 79 g23tikTNQKKIAELLAAID.GFKLCNKLRKEYIKVQKege17eqeMEEVDENIYFFEKMFDRST 80 v17gkkVLKQRVKAFGQIVK.GFRSGIDLLLALQKESNmms16lvgKSGLELFLSQFEAAIDSDF 81 v17gkkVLKQRVKAFGQIVK.GFRSGIDLLLALQKESNmms16lvgKSGLELFLSQFEAAIDSDF 82 ......AERCQVVEFX----.-----------------........------------------- 83 ......--------------.------------RSTVG........LSSLLQLPFIGEKIIK--- 84 ......--------------.------------RSTVG........LSSLLQLPFIGEKIIK--- 85 ......RRSIALKDLQSILT.FVNTIPRAVQVLRTHQGgrn14iapLEDINEHFSNLRILITATV 86 ......RRKANLQDLFRIYQ.VILRTPKILKVLHELDNsti14ksfLKDLTGLKQMVEQVVDFE- 87 ......RRKANLQDLFRIYQ.VILRTPKILKVLHELDNsti14ksfLKDLTGLKQMVEQVVDFE- 88 ......--------------.-----------------........------LKQMVEQVVDFE- 89 ......NKRGNLEDVLKIYQ.FSKRIPEIVQVFTSFLEdds23shhVEPLSKFEEMVETTVDLDA 90 ......NKRGNLEDVLKIYQ.FSKRIPEIVQVFTSFLEdds23shhVEPLSKFEEMVETTVDLDA 91 ......RGKATLEDVVRAYQ.VVIRLPGFIGTLEGVMDeay18relSDSLVKLQEMVETTVDLD- 92 ......RGSASLEDVVRIYQ.MAKALPKIVTVLDSLTSehk17nnhCKNLEKLIELVETTIDLE- 93 ......RGSASLEDVVRIYQ.MAKALPKIVTVLDSLTSehk17nnhCKNLEKLIELVETTIDLE- 94 ......--------------.-----------------........------------------- 95 ......RQAANLQDCYRLYQ.GINQLPNVIQALEK---........------------------- 96 ......RQAANLQDCYRLYQ.GINQLPNVIQALEKHEGkhq17tdlRSDFSKFQEMIETTLDMD- 97 ......RQAANLQDCYRLYQ.GINQLPNVIQALEKHEGkhq17tdlRSDFSKFQEMIETTLDMD- 98 ......RQAANLQDCYRLYQ.GINQLPNVIQALEKHEGkhq17tdlRSDFSKFQEMIETTLDMD- 99 ......RQAANLQDCYRLYQ.GINQLPNVIQALEKHEGkhq17tdlRSDFSKFQEMIETTLDMD- 100 ......RQAANLQDCYRLYQ.GINQLPNVIQALEKHEGkhq17tdlRSDFSKFQEMIETTLDMD- 101 ......RQAANLQDCYRLYQ.GINQLPSVIQALEKYEGrhq17idlRSDFSKFQEMIETTLDMD- 102 ......RQAANLQDCYRLYQ.GINQLPSVIQALEKYEGrhq17idlRSDFSKFQEMIETTLDMD- 103 ......RQAANLQDCYRLYQ.GVKQLPNVIQALEKYQGrhq17tdlRSDFSKFQEKIETTLDMD- 104 ......RQTANLQDCYRLYQ.AVNHLPTVVQAIEKYEGthq17sdlSSDFSKFQEMIETTLDMD- 105 ......KKSANLQPVVKLYQ.SCSRIPYIKGILQQYNGqfs19wmaKNRFGRFSSLVETAIDLA- 106 ......RRRGGLQHIIKLYQ.STIRLPFIKTAMQQYTGefa19lsdQDHLGKFIDLVECSVDLD- 107 ......RRRGGLQHIIKLYQ.SAIRLPFIKTAMQQYTGefa19lsdQDHLGKFIDLVECSVDLD- 108 ......MRKCTLQDLNRFYQ.AATLLETVEMQLIQLSEaeq19teiLKKVERFQVLCDEFFDFDY 109 p9dtvnAAESKITNLIYLKH.TLELVDPLKIAMKNCNTpll11sleDKRFGIILEKIKTVINDDA 110 p9dtvnAAESKITNLIYLKH.TLELVDPLKIAMKNCNTpll11sleDKRFGIILEKIKTVINDDA 111 nhsai.KPDQRINYVLLLKE.TLQSVKSLKDALNDQLIqsr13ifnNDAIMEIEKLINSCINEDC 112 nhsai.KPDQRINYVLLLKE.TLQSVKSLKDALNDQLIqsr13ifnNDAIMEIEKLINSCINEDC 113 rgll..SQEQEINNIILLKT.VLQNTFVIRKSIQNVSShll11ileHENVQHLLAIINEYIRNDC 114 s9wtvrESEAKINQIIKLMH.TLKVIQGIRTLLHSAKMksn13flkDPRFDQIMNILVEKVDDSL 115 ......MKRYIKKDFLFIEK.ALSVFFTVKKLFDKHNFdyw9dkfeEDSISKVYFLINSAISSAP 200 210 220 230 | | | | 1 -........SLAENRFTVLPNIDPDIDAKK.RRLIGLPSFLTEVAQKELENL...DsrIP..... 2 -........SLAENRFTVLPNIDPDIDAKK.RRLIGLPSFLTEVAQKELENL...DsrIP..... 3 -........SLAENRFTVLPNIDPEIDEKK.RRLMGLPSFLTEVARKELENL...DsrIP..... 4 -........SLAENRFTVLPNIDPEIDEKK.RRLMGLPSFLTEVARKELENL...DsrIP..... 5 -........SLAENRFTVLPNIDPEIDEKK.RRLMGLPSFLTEVARKELENL...DsrIP..... 6 -........SKIQGRVTVMNGIDEELDEIR.DTYENMPMVLTAIAKQEEARL...G..LPpys.. 7 -........SKIQGRVTVMNGIDEELDEIR.DTYENMPMVLTAIAKQEEARL...G..LPpys.. 8 -........SKIQGRVTVMNGIDEELDEIR.DTYENMPMVLTAIAKQEEARL...G..LPpys.. 9 -........SRDTKTLTINTGVDNRLDECR.NIYNHLEGILLDVARETQIFLlnt-..--mpq14 10 -........SRDTKTLTINTGVDNRLDECR.NIYNHLEGILLDVARETQIFLlnt-..--mpq14 11 L........MK------------------Q.KINEEEETEVIAQEAEEILQD...E..NA..... 12 L........MK------------------Q.KINEEEETEVIAQEAEEILQD...E..NA..... 13 Kqna23kdeIFELRDFIVNPSFNTKLRKLH.DTYQGVWQ-------------...-..--..... 14 Kqna23kdeIFELRDFIVNPSFNTKLRKLH.DTYQGVWQ-------------...-..--..... 15 D........LL--DILITSSDQFPELAEAR.QAVLVIREKLDSSIASFRKKL...A..IR..... 16 D........LL--DILITSSDQFPELAEAR.QAVLVIREKLDSSIASFRKKL...A..IR..... 17 D........LL--DILITSSDQFPELAEAR.QAVLVIREKLDSSIASFRKKL...A..IR..... 18 F........DLSEEPNDVDYELAQEIRELK.MSILMVRTEMDFHLQELRDYL...E..YP..... 19 F........DLSEEPNDVDYELAQEIRELK.MSILMVRTEMDFHLQELRDYL...E..YP..... 20 Nsdk.....QVMDFFNLNNYDCSEGIIKIQ.RESESVRSQLKEELAEIRKYL...K..RP..... 21 Nsdk.....QVMDFFNLNNYDCSEGIIKIQ.RESESVRSQLKEELAEIRKYL...K..RP..... 22 A........KVGDKTELFKDLSDFPLIKKRkDEIQGVIDEIRMHLQEIRKIL...K..NP..... 23 A........KVGDKTELFKDLSDFPLIKKRkDEIQGVIDEIRMHLQEIRKIL...K..NP..... 24 A........KVGDKTELFKDLSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL...K..LP..... 25 A........KVGDKTELFKDLSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL...K..LP..... 26 A........KVGDKTELFKDLSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL...K..LP..... 27 A........KVGDKTELFKDLSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL...K..LP..... 28 P........LRVSDGNIFVDEFHNDLKRLR.HNQEHSQEWIWEYQERIRKET...G..IK..... 29 P........LRVSDGNIFVDEFHNDLKRLR.HNQEHSQEWIWEYQERIRKET...G..IK..... 30 P........LKVSEGNIFADHYHQDLLRLR.NIKTNSKSWILEYQERIRQET...G..IK..... 31 P........LKVSEGNIFANHYHPDLLRLR.NIKENSKSWILEYQERIRNET...G..IK..... 32 P........NNLNDGGIIKYEFHPKIAQLN.DLINNKKLHVEKLKDQYRKET...R..IE..... 33 P........LLKRDGGFVREGASAELDEMR.ALRDQSRRVIAGLQLQYCEET...G..IK..... 34 P........VTLSDGNLIKRGFSASLDELH.RVRDNANEILKQYLAEERERT...G..IG..... 35 P........LHIREGNLIRSGVNPTLDEMR.QSLEDDNQWLANLEVTEREKT...G..IA..... 36 P........LHIREGNLIRSGVNPTLDEMR.QSLEDDNQWLANLEVTEREKT...G..IA..... 37 P........HVITDGGIIRTGFDETLDKYR.CVLREGTSWIAEIEAKERENS...G..IS..... 38 P........ISVKDGGLFKVGFNTQLDE--.---------------------...-..--..... 39 P........LSVKEGNLIKDGYNQKLDEYR.DASRNGKDWIARLEQQEREYT...G..IR..... 40 P........LSVKEGNLIKDGYNQKLDEYR.DASRNGKDWIARLEQQEREYT...G..IR..... 41 P........LKLTDGGVIASEYDVELDELR.KLSNNADQFLIDLETRERESS...G..IS..... 42 P........VVIRDGGVIADGYSAELDEWR.DLANGATEFLERLEAEERDRH...G..ID..... 43 Atsw11trrRYWSRRRVIAPGYHEELDEWR.ALADGATDYLDRLEIRERERT...G..LD..... 44 P........VLVRDGAVIAPGYHEELDEWR.ALADGATDYLDRLEIRERERT...G..LD..... 45 P........VLVRDGGVIASGYNEELDEWR.ALADGATDYLERLEVRERERT...G..LD..... 46 P........VLVRDGGVIASGYNEELDEWR.ALADGATDYLERLEVRERERT...G..LD..... 47 P........VLVRDGGVIASGYNEELDEWR.ALADGATDYLERLEVRERERT...G..LD..... 48 P........LLIRDGGVIAEGYNAELDEWR.MLSDGATQYLENLEKREREST...G..ID..... 49 P........AVIRDGGVIKTGYDAELDELQ.ALSENAGQFLMDLEAREKART...G..LP..... 50 P........AVIRDGGVIKTGYDAELDELQ.ALSENAGQFLMDLEAREKART...G..LP..... 51 P........AVIRDGGVLKQGYDAELDELL.SLSENAGQFLMDLEAREKART...G..LP..... 52 P........AVIRDGGVLKAGYDNELDEML.AISENAGQFLIDLEAREKART...G..LA..... 53 S........VWLKDGNVINHGFHPELDELR.RIQNHGDEFLLDLEAKERERT...G..LS..... 54 S........VWLKDGNVINHGFHPELDELR.RIQNHGDEFLLDLEAKERERT...G..LS..... 55 V........GSPGEGKVIKRGFSSELDEYR.DLLEHAEERLKEFEEKERERT...G..IQ..... 56 V........GSPGEGKVIKRGFSSELDEYR.DLLEHAEERLKEFEEKERERT...G..IQ..... 57 P........LHVKEGGLIKPGVNAYLDELR.FIRENAEKLLKEYEKKLKKET...G..IQ..... 58 P........LHVKEGGLIREGVNAYLDELR.FIRDNAETYLREYEKKLRQET...G..IQ..... 59 P........LKVSEGGVIREGYDPDLDALR.RAHADPVAYFLDLEVREKEST...G..IP..... 60 P........LKVSEGGLIREGYDPDLDALR.RAHAEGVAYFLDLEAREKERT...G..IP..... 61 P........LKVSEGGLIREGYDPDLDALR.RAHAEGVAYFLDLEAREKERT...G..IP..... 62 P........LKVSEGGLIREGYDPDLDALR.RAHAEGVAYFLDLEAREKERT...G..IP..... 63 P........LKVSEGGLIREGYDPDLDALR.AAHREGVAYFLELEERERERT...G..IP..... 64 P........LKVSEGGLIREGYDPDLDALR.AAHREGVAYFLELEERERERT...G..IP..... 65 Kswt10rqkAINENIIVPQRGFDIEFDKSM.DRIQELEDELMEILMTYRKQF...K..CS..... 66 Kswt10rqkAINENIIVPQRGFDIEFDKSM.DRIQELEDELMEILMTYRKQF...K..CS..... 67 -........ASEEGVFEPEIGFEAEYDTSQ.KYQSELKNELYALLEQYKKQL...R..CS..... 68 -........ADRNGRFIPYEGCDPEFDATC.NAIEEIKSSLKEYLKEQRKLL...R..PA..... 69 -........AHNSGRVIPHEGADEEYDCAC.KTVEEFESSLKKHLKEQRKLL...G..DA..... 70 -........AHNSGRVIPHEGADEEYDCAC.KTVEEFESSLKKHLKEQRKLL...G..DA..... 71 -........ARKTGLITPKAGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR..... 72 -........ARKTGLITPKAGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR..... 73 -........ARKTGLITPKAGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR..... 74 -........ARKTGLITPKAGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR..... 75 -........ARKTGLITPKAGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR..... 76 -........ARKTGLITPKAGFDSDYDQAL.ADIRENEQSLLEYLDKQRSRL...G..CK..... 77 -........ARKTGLITPKAGFDSDYDQAL.ADIRENEQSLLEYLDKQRSRL...G..CK..... 78 -........AAKTGVIAPQAGMDAEYDAAM.DSIGEVEKRLKTYLVEQERHF...G..CR..... 79 -........AMKDGKIVPNAGCDEEYDEAL.NRVKEALNELNDYKDSVAKKY...S..CS..... 80 P........N--------------------.---------------------...-..--..... 81 P........N--------------------.---------------------...-..--..... 82 -........---------------------.---------------------...-..--..... 83 -........KRIKTFIMLINGLRNGIDLLN.DLQRADHGILALY--------...-..--..... 84 -........KRIKTFIMLINGLRNGIDLLN.DLQRADHGILALY--------...-..--..... 85 D........LSDENTTRINPEFDDELMELE.EQRKSVVKAIESEHQRVMKVY...G..WTek... 86 -........AIERGEYLVKASFDSRLMELQ.QMMTELYSKMEELQFKCSQEL...N..LDgkn.. 87 -........AIERGEYLVKASFDSRLMELQ.QMMTELYSKMEELQFKCSQEL...N..LDgkn.. 88 -........AIERGEYLVKASFDSRLMELQ.QMMTELYSKMEELQFKCSQEL...N..LDgkn.. 89 -........YEENNEFMIKVEFNEELGKIR.SKLDTLRDEIHSIHLDSAEDL...G..FDpdk.. 90 -........YEENNEFMIKVEFNEELGKIR.SKLDTLRDEIHSIHLDSAEDL...G..FDpdk.. 91 -........ALDNHEFIIKPEFDDSLRIIR.KKLDRLRTDMDNEFAEAAEDL...G..QErek.. 92 -........ALDSHQYIIRAEFDEELLDLR.QRLDELQHSIFEEHKRVGSDL...H..QDtek.. 93 -........ALDSHQYIIRAEFDEELLDLR.QRLDELQHSIFEEHKRVGSDL...H..QDtek.. 94 -........---------------------.---------------------...-..--..... 95 -........---------------------.---------------------...-..--..... 96 -........QVENHEFLVKPSFDPNLSELK.---------------------...-..--..... 97 -........QVENHEFLVKPSFDPNLSELR.EIMNDLEKKMQSTLISAARDL...G..LDpgk.. 98 -........QVENHEFLVKPSFDPNLSELR.EIMNDLEKKMQSTLISAARDL...G..LDpgk.. 99 -........QVENHEFLVKPSFDPNLSELR.EIMNDLEKKMQSTLISAARDL...G..LDpgk.. 100 -........QVENHEFLVKPSFDPNLSELR.EIMNDLEKKMQSTLISAARDL...G..LDpgk.. 101 -........QVENHEFLVKPSFDPNLSELR.EVMDGLEKKMQSTLINAARGL...G..LDpgk.. 102 -........QVENHEFLVKPSFDPNLSELR.EVMDGLEKKMQSTLINAARGL...G..LDpgk.. 103 -........QVENHEFLVKPSFDPNLSELR.EVMDGLEKKMQSTLISAARGL...G..LDpgk.. 104 -........QVENHEFLVKASFDPNLTELR.EKMDELEKNMQGALGGAAREL...G..LDagk.. 105 -........QLENGEYRISPLYSSDLGVLK.DELSVVENHINNLHVDTASDL...D..LSvdk.. 106 -........QLENGEYMISSSYDTKLASLK.DQKELLEQQIHELHKKTAIEL...D..LQvdk.. 107 -........QLENGEYMISSNYDTKLASLK.DQKELLEQQIHELHKKTAIEL...D..LQvdk.. 108 -........EKENKEIRVRVDFVPEIQEIS.EKLEQMERVAEKLRKKYSAKF...E..CD..... 109 Rymkgcln.MRTQKCYAVRSNINEFLDIAR.RTYTEIVDDIAGMISQLGEKY...S..LP..... 110 Rymkgcln.MRTQKCYAVRSNINEFLDIAR.RTYTEIVDDIAGMISQLGEKY...S..LP..... 111 Vwassaiq.LLNQRSYAVKSDSNGLLDVSR.QIYKEVKEEFFREVEDLTAKN...K..IN..... 112 Vwassaiq.LLNQRSYAVKSDSNGLLDVSR.QIYKEVKEEFFREVEDLTAKN...K..IN..... 113 Qwannste.LANQRANAVKSGVNGLLDVSR.RIRETLLEEVSELVAKLSEEL...E..IF..... 114 LdgkknslhLQNTKCYAIRHFVAVQLDLAR.QTYEEIIRNVEETGAREIAEYfh.G..NS..... 115 D........------ELIKRGYDLKLDNLK.DLKINANKYIDQYLESERLLS...K..IN..... 240 250 260 270 280 | | | | | 1 ...SCSVIYIPLIGFLLSIPR---....---......---....---------...--------- 2 ...SCSVIYIPLIGFLLSIPR---....---......---....---------...--------- 3 ...SCSVIYIPLIGFLLSIPR---....---......---....---------...--------- 4 ...SCSVIYIPLIGFLLSIPR---....---......---....---------...--------- 5 ...SCSVIYIPLIGFLLSIPR---....---......---....---------...--------- 6 ...NVACVYIPLVGFVLSVPRDY-....---......---....---------...--------- 7 ...NVACVYIPLVGFVLSVPRDY-....---......---....---------...--------- 8 ...NVACVYIPLVGFVLSVPRDY-....---......---....---------...--------- 9 lekLVNAVYIPQLGYLVTISVLME....PLLdgip..NLQ....WEEIFRSSE...NIYFKNGRV 10 lekLVNAVYIPQLGYLVTISVLME....PLLdgip..NLQ....WEEIFRSSE...NIYFKNGRV 11 ...QVEIVKKS-----LSSEFDIR....QSF......KEN....WVVKSNFNN...NLRKLHEKL 12 ...QVEIVKKS-----LSSEFDIR....QSF......KEN....WVVKSNFNN...NLRKLHEKL 13 ...---------------------....---......---....---------...--------- 14 ...---------------------....---......---....---------...--------- 15 ...NLEFLQVSGITHLIELPVD--....SKV......PMN....WVKVNSTKK...TIRYHPPEI 16 ...NLEFLQVSGITHLIELPVD--....SKV......PMN....WVKVNSTKK...TIRYHPPEI 17 ...NLEFLQVSGITHLIELPVD--....SKV......PMN....WVKVNSTKK...TIRYHPPEI 18 ...NLEFSIWGNVKFCIEVSKGC-....KKI......PPD....WIKLSSTRS...LFRFHTPKI 19 ...NLEFSIWGNVKFCIEVSKGC-....KKI......PPD....WIKLSSTRS...LFRFHTPKI 20 ...YLNFR--DEVDYLIEVKNSQI....KDL......PDD....WIKVNNTKM...VSRFTTPRT 21 ...YLNFR--DEVDYLIEVKNSQI....KDL......PDD....WIKVNNTKM...VSRFTTPRT 22 ...SAQYVTVSGQEFMIEIKNSAV....SCI......PTD....WVKVGSTKA...VSRFHSPFI 23 ...SAQYVTVSGQEFMIEIKNSAV....SCI......PTD....WVKVGSTKA...VSRFHSPFI 24 ...SLQYVTVSGQEFMIEIKNSAV....SCI......PAD....WVKVGSTKA...VSRFHPPFI 25 ...SLQYVTVSGQEFMIEIKNSAV....SCI......PAD....WVKVGSTKA...VSRFHPPFI 26 ...SLQYVTVSGQEFMIEIKNSAV....SCI......PAD....WVKVGSTKA...VSRFHPPFI 27 ...SLQYVTVSGQEFMIEIKNSAV....SCI......PAD....WVKVGSTKA...VSRFHPPFI 28 ...KLKICFAQALGYYIEVSSEFA....PQL......PKD....FIRRQSRLH...AERFTTIEL 29 ...KLKICFAQALGYYIEVSSEFA....PQL......PKD....FIRRQSRLH...AERFTTIEL 30 ...KLKVCYAQALGYYIEVASSFA....PQL......PKE....FIRRQSRLH...AERFTTQEL 31 ...KLKVCYAQALGYYIEVASNLA....PQL......PKE....FIRRQSRLH...AERFTTQEL 32 ...SLKISHNNVLGFFIDITPKNV....NKIl.....DPK....FIHRQTTIN...SVRYTTYEL 33 ...SLKIKHNNVLGYFIEVTAGNA....GSMtdtdagRAR....FIHRQTMAN...AMRFTTTEL 34 ...TLKMKYNRMLGHFLEVSKGHL....SAV......PAH....FIRRRSLSN...ADRFTTEQL 35 ...NLKVGYNKAFGYYLSLPRSKS....EQA......PDN....YIRKQTLVN...EERYITPEL 36 ...NLKVGYNKAFGYYLSLPRSKS....EQA......PDN....YIRKQTLVN...EERYITPEL 37 ...TLKIDYNKKDGYYFHVTNSQL....GNV......PAH....FFRKATLKN...SERFGTEEL 38 ...---------------------....---......---....---------...--------- 39 ...SLKVGFNKVFGYYIEVTKANL....HLL......EEGr...YERNETLTN...AERYITPEL 40 ...SLKVGFNKVFGYYIEVTKANL....HLL......EEGr...YERNETLTN...AERYITPEL 41 ...TLKVGYNRVHGYYIEISKGQA....DKA......PVH....YTRRQTLTN...AERYITEEL 42 ...TLKVGYNNVHGFYIQVSRGQS....HLV......PPH....YVRRQTLKN...AERYIIEEL 43 ...TLKVGYNAVHGYYIQISRGQS....HLA......PIN....YVRRQTLKN...AERYIIPEL 44 ...TLKVGYNAVHGYYIQISRGQS....HLA......PIN....YVRRQTLKN...AERYIIPEL 45 ...TLKVGFNAVHGYYIQISRGQS....HLA......PIN....YMRRQTLKN...AERYIIPEL 46 ...TLKVGFNAVHGYYIQISRGQS....HLA......PIN....YMRRQTLKN...AERYIIPEL 47 ...TLKVGFNAVHGYYIQISRGQS....HLA......PIN....YMRRQTLKN...AERYIIPEL 48 ...TLKIGFNAVHGYYIQISQGQA....HKA......PIH....YVRRQTLKN...AERYIIPEL 49 ...NLKVGYNRIHGYFIELPRVQA....EQA......PAD....YIRRQTLKG...AERFITPEL 50 ...NLKVGYNRIHGYFIELPRVQA....EQA......PAD....YIRRQTLKG...AERFITPEL 51 ...NLKVGYNRIHGYYIELPRVQA....EQA......PAD....YIRRQTLKG...AERFITPEL 52 ...NLKVGYNRVHGYFIELPTKQA....EQA......PGD....YIRRQTLKG...AERFITPEL 53 ...TLKVEFNRVHGFYIELSKTQA....EQA......PAD....YQRRQTLKN...AERFITPEL 54 ...TLKVEFNRVHGFYIELSKTQA....EQA......PAD....YQRRQTLKN...AERFITPEL 55 ...KLRVGYNQVFGYYIEVTKANL....DKI......PDD....YERKQTLVN...SERFITPEL 56 ...KLRVGYNQVFGYYIEVTKANL....DKI......PDD....YERKQTLVN...SERFITPEL 57 ...SLKIGYNKVMGYYIEVTKANV....KYV......PEH....FRRRQTLSN...AERYTTEEL 58 ...SLKIGYNKVMGYYIEVTKPNL....KYV......PSY....FRRRQTLSN...SERFTTEEL 59 ...TLKVGYNAVFGYYLEVTRPYY....EKV......PQE....YRPVQTLKD...RQRYTLPEM 60 ...TLKVGYNAVFGYYLEVTRPYY....EKV......PQE....YRPVQTLKD...RQRYTLPEM 61 ...TLKVGYNAVFGYYLEVTRPYY....EKV......PQE....YRPVQTLKD...RQRYTLPEM 62 ...TLKVGYNAVFGYYLEVTRPYY....EKV......PQE....YRPVQTLKD...RQRYTLPEM 63 ...TLKVGYNAVFGYYLEVTRPYY....ERV......PKE....YRPVQTLKD...RQRYTLPEM 64 ...TLKVGYNAVFGYYLEVTRPYY....ERV......PKE....YRPVQTLKD...RQRYTLPEM 65 ...NIQYKDSGKEIYTIEIPISAT....KNV......PSN....WVQMAANKT...YKRYYSDEV 66 ...NIQYKDSGKEIYTIEIPISAT....KNV......PSN....WVQMAANKT...YKRYYSDEV 67 ...SLNFKNIGKEVYQVEVPSDV-....-KV......PVN....WCKMSGTKK...TNRYYNDEL 68 ...SVNYVNVGKDMYLIEVPESLG....GSV......PRN....YELQSTKKG...FYRYWTPEL 69 ...SINYVTVGKDEYLLEVPESLS....GSV......PHD....YELCSSKKG...VSRYWTPTI 70 ...SINYVTVGKDEYLLEVPESLS....GSV......PHD....YELCSSKKG...VSRYWTPTI 71 ...TIVYWGIGRNRYQLEIPENFT....TRNl.....PEE....YELKSTKKG...CKRYWTKTI 72 ...TIVYWGIGRNRYQLEIPENFT....TRNl.....PEE....YELKSTKKG...CKRYWTKTI 73 ...TIVYWGIGRNRYQLEIPENFT....TRNl.....PEE....YELKSTKKG...CKRYWTKTI 74 ...TIVYWGIGRNRYQLEIPENFT....TRNl.....PEE....YELKSTKKG...CKRYWTKTI 75 ...TIVYWGIGRNRYQLEIPENFT....TRNl.....PEE....YELKSTKKG...CKRYWTKTI 76 ...SIVYWGIGRNRYQLEIPENFA....TRNl.....PEE....YELKSTKKG...CKRYWTKTI 77 ...SIVYWGIGRNRYQLEIPENFA....TRNl.....PEE....YELKSTKKG...CKRYWTKTI 78 ...-ITYFGSDKKRYQLDVPESHA....SKA......NKS....YTLEGQTKGkkpSRRYTTAET 79 ...-IKFVDSGKVKYLLEMPEN--....TKV......SSS....FELKSRRKG...FIRYSTPDS 80 ...---------------------....---......---....---------...--------- 81 ...---------------------....---......---....---------...--------- 82 ...---------------------....---......---....---------...--------- 83 ...--KIVDIPSLSYLPELIHKFE....ERM......QNE....FP-------...--------- 84 ...--KIVDIPSLSYLPELIHKFE....ERM......QNE....FP-------...--------- 85 ...QLKCEYHTTYGYVFRVTRKED....QQVrt....SKE....LITVSTSKD...GVRFVSERL 86 ...QVKLESVAKLGHHFRITVKDD....SVLrk....NKN....YRIVDVIKG...GVRFTSDKL 87 ...QVKLESVAKLGHHFRITVKDD....SVLrk....NKN....YRIVDVIKG...GVRFTSDKL 88 ...QVKLESVAKLGHHFRITVKDD....SVLrk....NKN....YRIVDVIKG...GVRFTSDKL 89 ...KLKLENHHLHGWCMRLTRNDA....KEL......RKHkk..YIELSTVKA...GIFFSTKQL 90 ...KLKLENHHLHGWCMRLTRNDA....KEL......RKHkk..YIELSTVKA...GIFFSTKQL 91 ...KIFLENHKVHGWCMRLTRTEA....GCIrn....NSR....YLECSTQKN...GVYFTTKTL 92 ...KLHLEQHHLYGWCLRLTRTEA....GCLrgr...SSH....YTELSTQKN...GVYFTTKRL 93 ...KLHLEQHHLYGWCLRLTRTEA....GCLrgr...SSH....YTELSTQKN...GVYFTTKRL 94 ...---------------------....---......---....---------...--------- 95 ...---------------------....---......---....---------...--------- 96 ...---------------------....---......---....---------...--------- 97 ...QIKLDSSAQFGYYFRVTCKE-....---......---....---------...--------- 98 ...QIKLDSSAQFGYYFRVTCKEE....KVLrn....NKN....FSTVDIQKN...GVKFTNSKL 99 ...QIKLDSSAQFGYYFRVTCKEE....KVLrn....NKN....FSTVDIQKN...GVKFTNSKL 100 ...QIKLDSSAQFGYYFRVTCKEE....KVLrn....NKN....FSTVDIQKN...GVKFTNSKL 101 ...QIKLDSSAQFGYYFRVTCKEE....KVLrn....NKN....FSTVDIQKN...GVKFTNSEL 102 ...QIKLDSSAQFGYYFRVTCKEE....KVLrn....NKN....FSTVDIQKN...GVKFTNSEL 103 ...QIKLDSSAQFGYYFRVTCKEE....KVLrn....NKN....FSTVDIQKN...GVKFTNSEL 104 ...SIKLESNSQIGHYFRVTCKEE....KALrn....NKK....FTTIDIQKN...GVRFTNSKL 105 ...QLKLEK-GSLGHVFRMSKKEE....QKV......RKKltgsYLIIETRKD...GVKFTNSKL 106 ...ALKLDKAAQFGHVFRITKKEE....PKI......RKKlttqFIVLETRKD...GVKFTNTKL 107 ...ALKLDKAAQFGHVFRITKKEE....PKI......RKKlttqFIVLETRKD...GVKFTNTKL 108 ...NLKLDKNSQYGFYFRVTLKEE....KSI......RKKdv..HILETTKGS...GVKFSVGEL 109 ...-LRTSLSSVRGFFIQMTTDCIalpsDQL......PSE....FIKISKVKN...SYSFTSADL 110 ...-LRTSFSSARGFFIQMTTDCIalpsDQL......PSE....FIKISKVKN...SYSFTSADL 111 ...-LDHNYDSARGFYLRIKRQEF....TDDvatl..PDV....FISRTIKKN...YIECTTLNI 112 ...-LDHNYDSARGFYLRIKRQEF....TDDvatl..PDV....FISRTIKKN...YIECTTLNI 113 ...-MEYRFEISRGFFIKIKGNNT....DINsl....PEV....LINRVKKRK...TIECTTIEL 114 ...SVRLSFSQSRGFHYTFVTRQA....ESVti....PRY....FLDVFRNRT...TVTFNSRKV 115 ...NLKIRKTNNRGLFFEVTKSNY....AQV......PPH....FMESQALNS...SKRYKTEKL 290 300 | | 1 ------------------- 2 ------------------- 3 ------------------- 4 ------------------- 5 ------------------- 6 ------------------- 7 ------------------- 8 ------------------- 9 LELDE-------------- 10 LELDE-------------- 11 QSLFASYDKLQEDL----- 12 QSLFASYDKLQEDL----- 13 ------------------- 14 ------------------- 15 VAGLDEL------------ 16 VAGLDEL------------ 17 VAGLDEL------------ 18 QSLLIELSSHEEN------ 19 QSLLIELSSHEEN------ 20 QKLTQKLEYYKDLL----- 21 QKLTQKLEYYKDLL----- 22 VENYRHLNQLREQ------ 23 VENYRHLNQLREQ------ 24 VESYRRLNQLREQ------ 25 VESYRRLNQLREQ------ 26 VESYRRLNQLREQ------ 27 VESYRRLNQLREQ------ 28 QQFQDDMSNISEKLQTLE- 29 QQFQDDMSNISEKLQTLE- 30 QQFQDEVFSVEDKLQTLE- 31 QQFQDEVFSVEDKLQTLE- 32 QNLENELVNAQTLVIRLE- 33 AELETKIANAADRALAIE- 34 SELEAKLARAREGLVSFE- 35 KERETRILTAQADLNQLE- 36 KERETRILTAQADLNQLE- 37 ARIEGDMLEAREKSANL-- 38 ------------------- 39 KEKEALILEAENNICELE- 40 KEKEALILEAENNICELE- 41 KAFEDKVLSARDRALVRE- 42 KQHEDKVLNSKSRALALE- 43 KEYEDKVLTSKGKALALE- 44 KEYEDKVLTSKGKALALE- 45 KEYEDKVLTSKGKALALE- 46 KEYEDKVLTSKGKALALE- 47 KEYEDKVLTSKGKALALE- 48 KEYEDKVLKSKGAALALE- 49 KAFEDKALSAQSRALARE- 50 KAFEDKALSAQSRALARE- 51 KAFEDKALSAKSRALARE- 52 KAFEDKALSAKSRALARE- 53 KAFEDKVLTAQEQALALE- 54 KAFEDKVLTAQEQALALE- 55 KEFETKIMAAKERIEELE- 56 KEFETKIMAAKERIEELE- 57 QRLEEKILSAQTRINELE- 58 QRLEEKILSAQTRINDLE- 59 KERERELYRLEALIKRREE 60 KERERELYRLEALIKRREE 61 KERERELYRLEALIKRREE 62 KERERELYRLEALIKRREE 63 KEKEREVYRLEALIRRREE 64 KEKEREVYRLEALIRRREE 65 RALARSMAEAKEIHKTLEE 66 RALARSMAEAKEIHKTLEE 67 RKKIKKLLEAEEL------ 68 KELILELSKAES------- 69 KKLLKELSQAKSE------ 70 KKLLKELSQAKSE------ 71 EKKLANLINAEE------- 72 EKKLANLINAEE------- 73 EKKLANLINAEE------- 74 EKKLANLINAEE------- 75 EKKLANLINAEE------- 76 EKKLANLINAEER------ 77 EKKLANLINAEER------ 78 RALLKDMQHAE-------- 79 EQLVAALDAVEKE------ 80 ------------------- 81 ------------------- 82 ------------------- 83 ------------------- 84 ------------------- 85 SSLSEQYKGIRK------- 86 EGYADEFASCRTRYEE--- 87 EGYADEFASCRTRYEE--- 88 EGYADEFASCRTRYEE--- 89 KSIANETNILQKEYD---- 90 KSIANETNILQKEYD---- 91 QALRREFDQLSQNYN---- 92 HSLNNS------------- 93 HSLNNSYMDHQKS------ 94 ------------------- 95 ------------------- 96 ------------------- 97 ------------------- 98 TSLNEEYTKNKTEYEEAQD 99 TSLNEEYTKNKTEYEEAQD 100 TSLNEEYTKNKTEYEEAQD 101 SSLNEEYTKNKGEYEEAQD 102 SSLNEEYTKNKGEYEEAQD 103 SSLNEEYTKNKGEYEEAQD 104 SSLSEEYMRNREEYEEAQ- 105 KNLSDQYQALFGEYTSCQ- 106 KKLGDQYQSVVDDYRSCQ- 107 KKLGDQYQSVVDDYRSCQ- 108 SDINDEFLEFHLKYTRAE- 109 IKMNERCQES--------- 110 IKMNERCQES--------- 111 IKKNARLKEVMEEI----- 112 IKKNARLKEVMEEI----- 113 MKQSSRYNDIVSEIT---- 114 IAYNDRLEQVVAE------ 115 ISLEVDINNAEDNVVAFE-