(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html

Citations (SAM, SAM-T99, HMMs)

Sequence numbers correspond to the following labels:

    • T0116-201-500 MutS, Thermus Aquaticus
    • gi|2135744|pir||I37550_264:575 mismatch repair protein MSH2 - human (Homo sapiens)
    • gi|1079805|gb|AAA82080.1| (U41221) similar to S. cerevisiae Msh2p (Swiss-Prot accession number P25847) and bacterial MutS proteins (Swiss-Prot accession numbers P23909, P10339, and P27345) [Homo sapiens] (Homo sapiens)
    • gi|2506881|sp|P54276|MSH6_MOUSE_662:1021 DNA MISMATCH REPAIR PROTEIN MSH6 (MUTS-ALPHA 160 KDA SUBUNIT) (G/T MISMATCH BINDING PROTEIN) (GTBP) (GTMBP) (P160) (Mus musculus)
    • gi|1817725|gb|AAC53034.1| (U42190) G/T-mismatch binding protein [Mus musculus] (Mus musculus)
    • gi|387849|gb|AAB60711.1|_443:753 (L10319) MutS homologue; major mRNA product contains exon 1a and exon 9b; alternative protein produced from exon 1b and exon 9b [Mus musculus] (Mus musculus)
    • gi|400971|sp|P13705|MSH3_MOUSE_443:753 DNA MISMATCH REPAIR PROTEIN MSH3 (REPAIR-3 PROTEIN) (REP-1) (Mus musculus)
    • gi|200706|gb|AAA40052.1| (M80360) Citations 2 and 3 contain revisions to the original sequence in Citation 1. The name of the gene was changed after Citation 1 from Rep-1 to Rep-3 to avoid naming conflict with an unrelated gene.; complete cds of major mRNA [Mus musculus] (Mus musculus)
    • gi|7287834|gb|AAF44872.1|AE003406_77_250:570 (AE003416) symbol=spel1; synonym=BG:DS01068.9; cDNA=method:''sim4'', score:''1000.0'', desc:''LD33650 LD Drosophila melanogaster embryo pOT2 Drosophila melanogaster cDNA clone LD33650 5prime, mRNA sequence:AA979275''; match=method:''sim4'', score:''100> (Drosophila melanogaster)
    • gi|1000883|gb|AAB59571.1|_262:529 (L47579) Insertion mutation results in premature stop [Homo sapiens] (Homo sapiens)
    • gi|7331984|gb|AAF60672.1|_1110:1457 (AC024791) contains similarity to Pfam family PF00488 (DNA mismatch repair proteins, mutS family), score=296.7, E=2.9e-85, N=1 [Caenorhabditis elegans] (Caenorhabditis elegans)
    • gi|7012942|gb|AAF35250.1|AF227632_1_1:276 (AF227632) mismatch binding protein Mus3 [Zea mays] (Zea mays)
    • gi|1000879|gb|AAB59570.1|_262:482 (L47578) The base insertion results in premature stop [Homo sapiens] (Homo sapiens)
    • gi|3886083|gb|AAC78226.1|_259:546 (AF106587) contains similarity to DNA mismatch repair proteins, mutS (Pfam: PF00488, score=376.5, E=2.8e-109, N=1) [Caenorhabditis elegans] (Caenorhabditis elegans)
    • gi|5815430|gb|AAD52669.1|AF178755_1_159:495 (AF178755) HIM-14 protein [Caenorhabditis elegans] (Caenorhabditis elegans)
    • gi|5921981|gb|AAB93433.2| (U58758) C. elegans HIM-5 (GB:AF178755); contains similarity to Pfam domain PF00488 (mutS), Score=204.6, E-value=4.9e-58, N=1 [Caenorhabditis elegans] (Caenorhabditis elegans)
    • gi|1000875|gb|AAB59568.1|_262:377 (L47576) Frameshift mutation results in premature stop [Homo sapiens] (Homo sapiens)
              10        20        30                  40               
              |         |         |                   |               
   1 MLSEAPFEPEGEGPLALRRARGALLAYAQRT.....QGGA.....LSLQP..FRFYDP.....G.
   2 FGTRDLVGFGVEQAKLGLCAAGCLIQYVKDT.....QRTA.....LPHIRs.LTWDRQ.....D.
   3 --SEAPFEPEGEGPLALRRARGALLAYAQRT.....QGGA.....LSLQP..FRFYDP.....G.
   4 FGTRDLVGFGVENAPRGLCAAGCLLQYAKDT.....QRTT.....LPHIRs.ITMERE.....Q.
   5 FGTRDLVGFGVENAPRGLCAAGCLLQYAKDT.....QRTT.....LPHIRs.ITMERE.....Q.
   6 FGTRDLVGFGVENAPRGLCAAGCLLQYAKDT.....QRTT.....LPHIRs.ITMERE.....Q.
   7 ---KSLEGMGCEGLPLAIRAAGGLLEYIEDTq....KAHV.....VPIQP..LKTYGL.....T.
   8 ---KSLEGMGCEGLPLAIRAAGGLLEYIEDTq....KAHV.....VPIQP..LKTYGL.....T.
   9 FGTQDLKGFGCQNLTLAIGAAGCLLAYAKET.....QRTA.....LPHLRs.LRHDRL.....D.
  10 FGTQDLKGFGCQNLTLAIGAAGCLLAYAKET.....QRTA.....LPHLRs.LRHDRL.....D.
  11 --TQDLKGFGCDGLGLAIGAAGCLLAYARET.....QRTA.....LPHLRg.LRHERL.....D.
  12 -GTKDLRAFGVEKSPLGLSAAGCLLQYAKET.....QRTA.....LPHIQs.ISLIQN.....Q.
  13 ---EAPFEPQGEGPLALRRAQGALLAYARAT.....QGGA.....LSVRP..FRLYDP.....G.
  14 ---EAPFEPQGEGPLALRRAQGALLAYARAT.....QGGA.....LSVRP..FRLYDP.....G.
  15 ---EAPFEPQGEGPLALRRAQGALLAYARAT.....QGGA.....LSVRP..FRLYDP.....G.
  16 --------------QVAVSSLSAVIKFLELLs....DDSN.....FGQFE..LTTFDF.....S.
  17 --------------QVAVSSLSAVIKFLELLs....DDSN.....FGQFE..LTTFDF.....S.
  18 --------------QVAVSSLSAVIKFLELLs....DDSN.....FGQFE..LTTFDF.....S.
  19 ---EAPFDPEGEAPLALSRARGALLAYARAT.....QGGA.....LSVRP..FRLYDP.....G.
  20 -------------NQVAVSSLSAVIKFLELLs....DDSN.....FGQFE..LATFDF.....S.
  21 -------------NQVAVSSLSAVIKFLELLs....DDSN.....FGQFE..LATFDF.....S.
  22 --------------QVAVSSLSAVIKFLELLs....DDSN.....FGQFE..LATFDF.....S.
  23 FGTRDLVGFGVENASRGLCAAGCLLQYVKDT.....QRTS.....LPHIRs.ITMERQ.....Q.
  24 -----------ELSPLALKALAALIKYVKYTm....IAED.....LNLKP..PLLISQ.....R.
  25 FQVSSLDGFGLQGLVPAINAAGALLSYIQDK.....LLLP.....ISHLSi.PKIYGQ.....Q.
  26 -ESDSVGLTPGEESELALSALGGIVFYLKKCli...DQEL.....LSMAN..FEEYFPl18kaS.
  27 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli...DQEL.....LSMAN..FEEYIPl18kaY.
  28 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli...DQEL.....LSMAN..FEEYIPl18kaY.
  29 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli...DQEL.....LSMAN..FEEYIPl18kaY.
  30 -----------ELSPLALKALAALIKYVKYTm....IGED.....LNLKP..PLLISQ.....R.
  31 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli...DQEL.....LSMAN..FEEYIPl18kaY.
  32 FQVSSLDGFGLQGLVPAINAAGALLSYIQDK.....LLLP.....ISHLSi.PKIYGQ.....H.
  33 ----RGFGLDGKEHAVAIGAAGALLNYIRLT.....QNLM.....PQHLDg.LSLETD.....S.
  34 FQVASLDGFGLKGLVPAINAAGGLLSYIQDK.....LLLP.....TKHIAi.PQTRGK.....Q.
  35 FQVASLDGFGLKGLVPAINAAGGLLSYIQDK.....LLLP.....TKHIAi.PQTRGK.....Q.
  36 -ESDSVGLTPGEESELALSALGGIVFYLKKCli...DQEL.....LSMAN..FEEYFPl18kaS.
  37 ----RGFGLDGKEHAVAIGAAGALLNYIRLT.....QNLM.....PQHLDg.LSLETD.....S.
  38 -----------------------LYTYLKRT.....QKRS.....LDHLQp.VQVYEL.....E.
  39 -----------------------LYTYLKRT.....QKRS.....LDHLQp.VQVYEL.....E.
  40 ---EVLKSYYDTGKKVGFSAFGGLLYYLKWLkl...DKNL.....ISMKN..IKEYDFvks..Q.
  41 ---EVLKSYYDTGKKVGFSAFGGLLYYLKWLkl...DKNL.....ISMKN..IKEYDFvks..Q.
  42 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli...DQEL.....LSMAN..FEEYIPl18kaY.
  43 -----------RLATVEQTASSKLLQYVHRT.....QMRE.....LNHLKp.VIRYEI.....K.
  44 ----------LLPHSPDLAAAGALIAYLEET.....TRHP.....LSHVSa.ITRYHI.....H.
  45 -------------KQVAMSALAAVMKYLELLs....DESN.....FGQFV..MTNFDL.....S.
  46 FGTRDLVGFGVENASRGLCAAGCLLQYVKDT.....QRTS.....LPHIRs.ITMERQ.....Q.
  47 --GSQSLSGVINLEKPVICALAAVIRYLKEFn....LEKM.....LSKPEs.FKQLSS.....Gm
  48 --GSQSLSGVINLEKPVICALAAVIRYLKEFn....LEKM.....LSKPEs.FKQLSS.....Gm
  49 --GSQSLSGVINLEKPVICALAAVIRYLKEFn....LEKM.....LSKPEs.FKQLSS.....Gm
  50 --GSQSLSGVINLEKPVICALAAVIRYLKEFn....LEKM.....LSKPEs.FKQLSS.....Gm
  51 --------------DTYSLPLGAVYKYAKTT.....QKGY.....TPLIPr.PKPYRD.....E.
  52 --LHDLSGFGIENNPQATAAAGALLGYIEET.....QKQR.....LPHLTs.ITMETV.....G.
  53 --GSQIISGIVNLEKPVICSLAAIIKYLKEFn....LEKM.....LSKPEn.FKQLSS.....Km
  54 ---EDATGLKELQLQLASNALKTAIKYLDLVn....DAGN.....LGHYE..IKQLDL.....N.
  55 ---EDATGLKELQLQLASNALKTAIKYLDLVn....DAGN.....LGHYE..IKQLDL.....N.
  56 --GSQIISGIVNLEKPVICSLAAIIKYLKEFn....LEKM.....LSKPEn.FKQLSS.....Km
  57 ----RDIKGIGEISNSQICAIGSILEYLSLT.....QKQN.....IPHLPi.PKIINF.....H.
  58 ----SELATEDKNGSLALSALGGAIYYLRQA.....FLDEs10esLPYCD..FSNVNE.....K.
  59 ------LKSYLSEKPLAISAFGALFWYLRQLkl...DKDM.....CSMGN..FDEYDAsqq..S.
  60 ----SELATEDKNGSLALSALGGAIYYLRQA.....FLDEs10esLPYCD..FSNVNE.....K.
  61 ---------PQTDLKLAMGSASALIKYLGILh....DPSN.....FGQYQ..LYQHDL.....A.
  62 ------------ENQVAVSSLSAVIKFLELLs....DDSN.....FGQFE..LTTFDF.....S.
  63 -----------EDL---SLSLGAVYRYAKAT.....QKSF.....TPLIPk.PKPYVD.....E.
  64 --DDLALSLPQKYSKLSMGACNALIGYLQLLs....EQDQ.....VGKYE..LVEHKL.....K.
  65 --DDLALSLPQKYSKLSMGACNALIGYLQLLs....EQDQ.....VGKYE..LVEHKL.....K.
  66 ----EPVRDLVSGFDLATPALGALLSFSELLs....NEDN.....YGNFT..IRRYDI.....G.
  67 ---VGTLDGFGSFSRAELAAASAAVSYVEKT.....QLQE.....RPALGi.PERESA.....A.
  68 ----EPVRDLVSGFDLATPALGALLSFSELLs....NEDN.....YGNFT..IRRYDI.....G.
  69 --AIKVMNEKIQLSPSLIRLVSKLYSHMVEY.....NNEQ.....VMLIPsiYSPFAS.....K.
  70 --AIKVMNEKIQLSPSLIRLVSKLYSHMVEY.....NNEQ.....VMLIPsiYSPFAS.....K.
  71 ----------ELGLQLAMASCNALLRYLGPA.....LLNPdm9ntSRKLH..LYHHNL.....E.
  72 --IELHMEKVKSLHSLSIICLDMAISYLMEF.....SLED.....LFVASnfYQPFDS.....I.
  73 --IELHMEKVKSLHSLSIICLDMAISYLMEF.....SLED.....LFVASnfYQPFDS.....I.
  74 ---------PELGLQLAMASCNALLRYLGPA.....LLNPdm9ntSRKLH..LYHHNL.....E.
  75 ---SSILPKPSTDWQLALSAFGAIFWYLRDSli...DVDM.....LSMRN..VTIYNSn15wnG.
  76 ----EPVRDLLSQFDYALGPLGALLSYAELLa....DDTN.....YGNYT..IEKYNL.....N.
  77 -MSCLTVHTIMNMPHLTVQALALTFCHLKQF.....GFER.....ILYQGasFRSLSS.....N.
  78 -------------KTFALCAASAAISYMEEIis6srNLNA.....FRKLR..IQFEGT.....E.
  79 -------------KTFALCAASAAISYMEEIis6srNLNA.....FRKLR..IQFEGT.....E.
  80 ---EDATGLKELQLQLASNALKTAIKYLDLVn....DAGN.....LGHYE..IKQLDL.....N.
  81 -------------------------------.....----.....-----..------.....-.
  82 -MSCLTVHTIMNMPHLTVQALALTFCHLKQF.....GFER.....ILYQGasFRSLSS.....N.
  83 -MSCLTVQTIMNMPHLTVQALALTFCHLKQF.....GFER.....ILYQGasFRSLSS.....N.
  84 ---------------NMIRSFGALLLFLDET.....RMGVtd8vtSPIKS..IKTFTL.....G.
  85 ---------------NMIRSFGALLLFLDET.....RMGVtd8vtSPIKS..IKTFTL.....G.
  86 ------------ENQVAVSSLSAVIKFLELLs....DDSN.....FGQFE..LTTFDF.....S.
  87 ---DHLGLTPNDNYKLALKALGQCIFFIHKCkl...EPKV.....LPMAR..YQLYVPp16lrR.
  88 ---FSTVLMEVQSKYYCLAAVAALLKYVEFI.....QNSV.....YAPKSlkICFQGS.....E.
  89 ---FSTVLMEVQSKYYCLAAVAALLKYVEFI.....QNSV.....YAPKSlkICFQGS.....E.
  90 --ILFLSSIIPFDCVLTVRALGGLLKFLSRR.....RIGVel8vgVPILG..FKKFVL.....T.
  91 --ILFLSSIIPFDCVLTVRALGGLLKFLSRR.....RIGVel8vgVPILG..FKKFVL.....T.
  92 -------------------------------.....----.....--KYS..IFNYGT.....H.
  93 --ILFLSSIIPFDCLLTVRALGGLLKFLGRR.....RIGVel8vsVPILG..FKKFML.....T.
  94 --ILFLSSIIPFDCLLTVRALGGLLKFLGRR.....RIGVel8vsVPILG..FKKFML.....T.
  95 --ILGLSSLGFDEEKPYYISIFLIINHIKNN.....LKNL.....LSNIDk.IDINND.....S.
  96 -----RFTPIPLLIPSQVRALGGLLKFLGRR.....RIGVel8vsVPILG..FKKFML.....T.
  97 ----EIYSVNQTEHKLMYQATQLLLDYIHHT.....QKRD.....LSHIEd.VVQYAA.....I.
  98 -------RLALSNCPLASRAIEYLVSNIIDNf....DATN.....HRAFY..LKHTIP.....S.
  99 ---EIDPSFIKYCTKLEVTAGCTLISYIADRl....QNSH.....PNIQP..PIRVSL.....N.
 100 ---VSTVSEGCLRRTLALGALAVLLKYIHET.....RCVF.....FRVKSlrIKEMGV.....N.
 101 --NESTLGQVISNRKLSLAAANACIDYCVSTk....MFRV.....TNKIR..LKYCMC.....E.
 102 ---------------NMIRSFGALLLFLDET.....RMGVtd8vtSPIKS..IKTFTL.....G.
 103 ---EIDPSFIKYCTKLEVTAGCTLISYIADRl....QNSH.....PNIQP..PIRVSL.....N.
 104 ------------ENQVAVSSLSAVIKFLELLs....DDSN.....FGQFE..LTTFDF.....S.
 105 --SWNCAVDGLNECDVALSALGELINHLSRLk....LEDV.....LKHGDi.FPYQVY.....R.
 106 ------------NQDVVICALGGLIGHLTRLm....LHDA.....LKNGEv.LPYHVY.....K.
 107 ------------NQDVVICALGGLIGHLTRLm....LHDA.....LKNGEv.LPYHVY.....K.
 108 --SWNCAVDGLNECDVALSALGELINHLSRLk....LEDV.....LKHGDi.FPYQVY.....R.
 109 -------------------------------.....----.....-----..------.....-.
 110 -------------------------------.....----.....--IHG..IRYIDI.....R.
 111 -------------------------------.....----.....--IHG..IRYIDI.....R.
 112 --------------QKELAALRNTLIYVSNH.....LPDF.....SINFQi.PQRQLA.....T.
 113 --------------QKELAALRNTLIYVSNH.....LPDF.....SINFQi.PQRQLA.....T.
 114 ------------ENQVAVSSLSAVIKFLELLs....DDSN.....FGQFE..LTTFDF.....S.
 115 -------------------------------.....----.....-----..------.....-.


       50        60              70        80         90       100     
       |         |               |         |          |         |     
   1 AFMRLPEATLRALEVFEPLRG.Q.....DTLFSVLDETRT.APGRRLLQSWLRHPLLDRGPLEAR
   2 QSVILDAATRRNLELTHNLAG.Gtd...NTLAEVLDHCAT.PMGSRMLKRWIHQPMRDNATLNQR
   3 AFMRLPEATLRALEVFEPLRG.Q.....DTLFSVLDETRT.APGRRLLQSWLRHPLLDRGPLEAR
   4 DSIIMDAATRRNLEITQNLAG.Gae...NTLASVLDCTVT.PMGSRMLKRWLHMPVRDTRVLLER
   5 DSIIMDAATRRNLEITQNLAG.Gae...NTLASVLDCTVT.PMGSRMLKRWLHMPVRDTRVLLER
   6 DSIIMDAATRRNLEITQNLAG.Gae...NTLASVLDCTVT.PMGSRMLKRWLHMPVRHTRVLLER
   7 DFLVLDHQTRRNLEINQTVRD.Gsfh..GSLLWALDRTST.TMGSRALRRWLLQPLLDLKGIQAR
   8 DFLVLDHQTRRNLEINQTVRD.Gsfh..GSLLWALDRTST.TMGSRALRRWLLQPLLDLKGIQAR
   9 DTVILDGASRRNLELDINLSG.Gre...NTLQSVVDRCQT.AMASRLMSRWLNRPLRDRAVLEAR
  10 DTVILDGASRRNLELDINLSG.Gre...NTLQSVVDRCQT.AMASRLMSRWLNRPLRDRAVLEAR
  11 DTVILAGASRRNLELDVNLSG.Grd...NTLQSVIDRCQT.AMGSRLLGRWLNRPLRDRAVLEAR
  12 DCIQLDAATRRNLELTQNLAG.Gte...NTLASVLDKCVT.PMGSRLLKRWIHQPVRDVEKLKQR
  13 AFVRLPEASLKALEVFEPLRG.Q.....DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEAR
  14 AFVRLPEASLKALEVFEPLRG.Q.....DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEAR
  15 AFVRLPEASLKALEVFEPLRG.Q.....DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEAR
  16 QYMKLDIAAVRALNLFQGSVE.Dttgs.QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEER
  17 QYMKLDIAAVRALNLFQGSVE.Dttgs.QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEER
  18 QYMKLDIAAVRALNLFQGSVE.Dttgs.QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEER
  19 AIVRLPEASLKALEVFEPLRG.Q.....DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEAR
  20 QYMKLDMAAVRALNLFQGSVE.Dttgs.QSLAALLNKCKT.AQGQRLVNQWIKQPLMDRNRIEER
  21 QYMKLDMAAVRALNLFQGSVE.Dttgs.QSLAALLNKCKT.AQGQRLVNQWIKQPLMDRNRIEER
  22 QYMKLDMAAVRALNLFQGSVE.Dttgs.QSLAAFLNKCKT.AQGQRLVSQWIKQPLMDKNRIEER
  23 DSIIMDAATRRNLEITQNLAG.Gve...NTLAAVLDCTVT.PMGSRMLKRWLHMPVRNTDILRER
  24 DYMILDSATVENLSLIPGDRG.Kn....--LFDVLNNTET.PMGARLLKKWILHPLVDRKQIEER
  25 KHLLIDKASQTNLELLSPIHG.Ehgk..GSLLQVMERTST.PMGGRLLRNTLINPFYDLKEITLR
  26 QRMVLDAVTLNNLEIFLNGTN.Gste..GTLLERLDTCHT.PFGKRLLKQWLCAPLCSPSAISDR
  27 QRMVLDAVTLNNLEIFLNGTN.Gste..GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDR
  28 QRMVLDAVTLNNLEIFLNGTN.Gste..GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDR
  29 QRMVLDAVTLNNLEIFLNGTN.Gste..GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDR
  30 DYMILDSATVENLSWIPGDRG.Kn....--LFDVLNNTET.PMGARLGKKWILHPLVDRKQIEER
  31 QRMVLDAVTLNNLEIFLNGTN.Gste..GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDR
  32 KHLLIDKASQTNLELLSAIHG.Ehgk..GSLLQVMERTST.PMGGRLLRNTLVNPFYDLKEITLR
  33 QYIGMDAATRRNLEITQTLSG.Kks...PTLMSTLDLCAT.HMGSRLLALWLHHPLRNRAHIRAR
  34 QKLLIDTASQVNLELLAPLND.Pqgk..NSLLRIMDHTST.PMGGRLLRQILISPFYNPKEILVR
  35 QKLLIDTASQVNLELLAPLND.Pqgk..NSLLRIMDHTST.PMGGRLLRQILISPFYNPKEILVR
  36 QRMVLDAVTLNNLEIFLNGTN.Gste..GNLLERLDTCHT.PFGKRLLKQWLCAPLCSPSAISDR
  37 QYIGMDAATRRNLEITQTLSG.Kks...PTLMSTLDLCAT.HMGSRLLALWLHHPLRNRAHIRAR
  38 EAMKIDLYSKRNLELTETIRS.Knkk..GSLLWLLDETKT.AMGGRLLKQWIDRPLIRVNQIEER
  39 EAMKIDLYSKRNLELTETIRS.Knkk..GSLLWLLDETKT.AMGGRLLKQWIDRPLIRVNQIEER
  40 HSMVLDGITLQNLEIFSNSFD.Gsdk..GTLFKLFNRAIT.PMGKRMMKKWLMHPLLRKNDIESR
  41 HSMVLDGITLQNLEIFSNSFD.Gsdk..GTLFKLFNRAIT.PMGKRMMKKWLMHPLLRKNDIESR
  42 QRMVLDAVTLNNLEIFLNGTN.Gste..GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDR
  43 DFLQMDYATKASLDLVENARS.Gkkq..GSLFWLLDETKT.AMGMRLLRSWIHRPLIDKERIVQR
  44 DFVEIDDATRKNLEILQNLHD.Stha..HSLFETLNYTHT.AMGTRLLRYWLHHPLRSQEEIQKR
  45 QYMKLDNAAVGALNLFPGSAE.Dtsgt.QSLAGLLNKCKT.PQGQRLVNQWIKQPLMDKNRVEER
  46 DSIIMDAATRRNLEITQNLAG.Gve...NTLAAVLDCTVT.PMGSRMLKRWLHMPVRNTDILRER
  47 EFMRINGTTLRNLEILQNQTD.Mktk..GSLLWVLDHTKT.SFGRRKLKNWVTQPLLKLREINAR
  48 EFMRINGTTLRNLEILQNQTD.Mktk..GSLLWVLDHTKT.SFGRRKLKNWVTQPLLKLREINAR
  49 EFMRINGTTLRNLEMVQNQTD.Mktk..GSLLWVLDHTKT.SFGRRKLKNWVTQPLLKLREINAR
  50 EFMRINGTTLRNLEMVQNQTD.Mktk..GSLLWVLDHTKT.SFGRRKLKNWVTQPLLKLREINAR
  51 GFVRLDIKAIKGLEILESLEG.Rkd...ISLFKVIDRTLT.GMGRRRLKFRLLSPFRSREKIERI
  52 EAITMNAATRRHLELDTRVDG.Esr...HTLLGVLDSTVT.PMGGRLLRRWLHRPLRLREVVRQR
  53 EFMTINGTTLRNLEILQNQTD.Mktk..GSLLWVLDHTKT.SFGRRKLKKWVTQPLLKLREINAR
  54 RFVHLDSAAVAALNIMPKPGT.Hps8rwQSVLGVLDHCRT.PQGHRLMGQWVKQPLRSRNILNDR
  55 RFVHLDSAAVAALNIMPKPGT.Hps8rwQSVLGVLDHCRT.PQGHRLMGQWVKQPLRSRNILNDR
  56 EFMTINGTTLRNLEILQNQTD.Mktk..GSLLWVLDHTKT.SFGRRKLKKWVTQPLLKLREINAR
  57 NYMTIDFSTRRNLEIVTNLQG.Nly...GSVLNTLNHTVT.TQGGRLLYHFLSSPLTNIAKINHR
  58 QHMVLDAAALENLEIFENSRN.Ggys..GTLYAQLNQCIT.ASGKRLLKTWLARPLYNTELIKER
  59 TSLLMNGQTLKNLEIFSNSFD.Ggse..GTLFHLLCRCVT.PFGKRLFHTWLCHPLRSGTAINAR
  60 QHMVLDAAALENLEIFENSRN.Ggys..GTLYAQLNQCIT.ASGKRLLKTWLARPLYNTELIKER
  61 QFMKLDAAALKALNLMPGARD.Gakn..MSLYGLLNHCKT.PVGSRLLSQWLKQPLMNAEEIEKR
  62 QYMKLDIAAVRALNLFQGSVE.Dttgs.QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEER
  63 GYVKLDLKAVKGLEITESIEG.Rkd...LSLFKVVDRTLT.GMGRRRLRFRLLNPFRSIERIRKV
  64 EFMKLDASAIKALNLFPQGPQ.Np21kvTSLFQLLNHCKT.NAGVRLLNEWLKQPLTNIDEINKR
  65 EFMKLDASAIKALNLFPQGPQ.Np21kvTSLFQLLNHCKT.NAGVRLLNEWLKQPLTNIDEINKR
  66 GFMRLDSAAMRALNVMESKTD.Ankn..FSLFGLMNRTCTaGMGKRLLHMWLKQPLVDLNEIKTR
  67 STLFIDPATRANLELAKTLSG.Srd...GSLLKSLDRTMT.SGGARLLAERLMSPLTDPERINQR
  68 GFMRLDSAAMRALNVMESKTD.Ankn..FSLFGLMNRTCTaGMGKRLLHMWLKQPLVDLNEIKTR
  69 IHMLLDPNSLQSLDIFTHDGG.K.....GSLFWLLDHTRT.SFGLRMLREWILKPLVDVHQIEER
  70 IHMLLDPNSLQSLDIFTHDGG.K.....GSLFWLLDHTRT.SFGLRMLREWILKPLVDVHQIEER
  71 QYMRLDIAAVRSLNLLPPPNG.Nahkt.MSLYGLLNHCRT.AMGARNLRRWIVQPLLDAKSIERR
  72 SSMVLSKQALEGLELFVNQTD.Htpv..GSLFWVLDRTYT.RFGQRMLQRWLQKPLVDKENIIER
  73 SSMVLSKQALEGLELFVNQTD.Htpv..GSLFWVLDRTYT.RFGQRMLQRWLQKPLVDKENIIER
  74 QYMRLDIAAVRSLNLLPPPNG.Nahkt.MSLYGLLNHCRT.AMGARNLRRWIVQPLLDAKSIERR
  75 KNLILDGTALENLNIVPNGRD.Shl...TSLYYVINKCST.PFGRRLLRSWLLQPTCDPKKLEQR
  76 CYMRLDSAAVRALNIAEGKTDv-nkn..FSLFGLMNRTCTvGMGKRLLNRWLKQPLLDVNEINNR
  77 TEMTLSANTLQQLEVVKNNSD.Gses..GSLFHNMNHTLT.VYGSRLLRHWVTHPLCDRNLISAR
  78 NTMLIDSKTVRGLELVENKLD.Kng...ISLWKFLDTTST.KMGQRSLRNSILQPLTDRGSIEMR
  79 NTMLIDSKTVRGLELVENKLD.Kng...ISLWKFLDTTST.KMGQRSLRNSILQPLTDRGSIEMR
  80 RFVHLDSAAVAALNIMPKPGT.Hps8rwQSVLGVLDHCRT.PQGHRLMGQWVKQPLRSRNILNDR
  81 -----DTAALENLELLENTRT.Ggls..GTLYAQLNHCVT.GFGKRLLKRWIAKPLYDCREILRR
  82 TEMTLSANTLQQLEVVKNNSD.Gses..GSLFHNMNHTLT.VYGSRLLRHWVTHPLCDRNLISAR
  83 TEMTLSANTLQQLEVVKNNSD.Gses..GSLFHNMNHTLT.VYGSRLLRHWVTHPLCDRNLISAR
  84 NLVEIDFNTIQALDILPKETE.Nkk7qgRSLYQLMDKCRS.TVGKKCLRKWFRNPTTDRDDLVSR
  85 NLVEIDFNTIQALDILPKETE.Nkk7qgRSLYQLMDKCRS.TVGKKCLRKWFRNPTTDRDDLVSR
  86 QYMKLDIAAVRALNLFQGSVE.Dttgs.QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEER
  87 SHMVLDATTLSNLRII---GE.E.....HSLLSTLDHCCT.KFGKRLLHHWLCAPSCDVSVIKER
  88 QTAMIDSSSAQNLELLINNQD.Yrnn..HTLFGVLNYTKT.PGGSRRLRSNILEPLVDIETINMR
  89 QTAMIDSSSAQNLELLINNQD.Yrnn..HTLFGVLNYTKT.PGGSRRLRSNILEPLVDIETINMR
  90 HLVSIDQDTYSVLQIFKSESH.Ps12egLSLFGILNRCRC.KWGQKLLRLWFTRPTRELRELNSR
  91 HLVSIDQDTYSVLQIFKSESH.Ps12egLSLFGILNRCRC.KWGQKLLRLWFTRPTRELRELNSR
  92 GNMLIDSCAVEALELFQLNYN.Yle6nnLTLYNVLNKCKT.LPGEKLLRDWLSRPLCQIDHINER
  93 HLVNIDQDTYSVLQIFKSESH.Ps12egLSLFGILNRCHC.KWGEKLLRLWFTRPTHDLGELSSR
  94 HLVNIDQDTYSVLQIFKSESH.Ps12egLSLFGILNRCHC.KWGEKLLRLWFTRPTHDLGELSSR
  95 SYMFLDDVTQVNLELVKNNND.Fssq..YSLYSVLNDCKT.AMGKRLLREFILNPILNISEINTR
  96 HLVNIDQDTYSVLQIFKSESH.Ps12egLSLFGILNRCHC.KWGEKLLRLWFTRPTHDLGELSSR
  97 DYMKMDFYAKRNLELTESIRL.Kskk..GTLLWLMDETKT.PMGARRLKQWIDRPLISKEQIEAR
  98 TFMKLDTAAIQALHIIHQKPE.ArgslpTSVYSWLNRCVT.GMGSRMMRQWLLQPLRNAEDINQR
  99 EYMIIGESAMKGLEIRSSLYQ.Nryt..GSLLHAINKTVT.KSGSRLLTRRLCAPSTNIVEINNR
 100 DTCMIDFVSWESLEIVDADDA.Sk10qkRTLMSVLNHTVT.TNGYRLLRSSVLQPSTDVYLIQSR
 101 NTMLIDTCTVRDLELVDSLSE.Tg....TTLYSFLNCCLT.KMGMRILRTSILQPSTHENSIILR
 102 NLVEIDFNTIQALDILPKETE.Nkk7qgRSLYQLMDKCRS.TVGKKCLRKWFRNPTTDRDDLVSR
 103 EYMIIGESAMKGLEIRSSLYQ.Nryt..GSLLHAINKTVT.KSGSRLLTRRLCAPSTNIVEINNR
 104 QYMKLDIAAVRALNLFQGSVE.Dttgs.QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEER
 105 GCLRIDGQTMVNLEIFNNSCD.Ggps..GTLYKYLDNCVS.PTGKRLLRNWICHPLKDVESINKR
 106 TCLRMDGQTLVNLEIFINNFN.Ggss..GTLYKHLNHCVT.ASGKRMLRRWICHPLKDIDAINKR
 107 TCLRMDGQTLVNLEIFINNFN.Ggss..GTLYKHLNHCVT.ASGKRMLRRWICHPLKDIDAINKR
 108 GCLRIDGQTMVNLEIFNNSCD.Gvlq..GPLNKYLENCVS.PTGKRLLRNWICHPLKDVESINKR
 109 ---------------------.-.....------------.------------------------
 110 DRMVLDENTISALHIFPTAHK.Lg10gfFSVFELFNQVSS.DYARRILKSWLINPLTNKKRIETR
 111 DRMVLDENTISALHIFPTAHK.Lg10gfFSVFELFNQVSS.DYARRILKSWLINPLTNKKRIETR
 112 AIMQIDSRTSTALELHSTVRD.Nnkk..GSLLSSIRRTVT.PSGTRLLSQWLSGPSLDLKEIKKR
 113 AIMQIDSRTSTALELHSTVRD.Nnkk..GSLLSSIRRTVT.PSGTRLLSQWLSGPSLDLKEIKKR
 114 QYMKLDIAAVRALNLFQGSVE.Dttgs.QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEER
 115 -CLHXPGPTLRALDVFHSSVG.Lr....GSLVGLLDHSVT.PCGSRCLRRWLTAPLCERASIVAR


        110                 120          130       140            150  
         |                   |            |         |              |  
   1 LDRVEGFV.....R.....EGALREGVR...RLLYRLADLERLATRLE.....LGRASPKDLGAL
   2 LDAITELK.....-.....ETALYGELH...PVLKQIGDIERILARLA.....LRSARPRDLARL
   3 LDRVEGFV.....R.....EGALREGVR...RLLYRLADLERLATRLE.....LGRASPKDLGAL
   4 QQTIGAL-.....-.....-QDFTAELQ...PVLRQVGDLERILARLA.....LRTARPRDLARM
   5 QQTIGAL-.....-.....-QDFTAGLQ...PVLRQVGDLERILARLA.....LRTARPRDLARM
   6 QQTIGAL-.....-.....-QDFTAELQ...PVLRQVGDLERILARLA.....LRTARPRDLARM
   7 QDTIQELY.....H.....HPALRQDLR...QLLRQIYDLERLTGRIG.....ANTASARDVYGL
   8 QDTIQELY.....H.....HPALRQDLR...QLLRQIYDLERLTGRIG.....ANTASARDVYGL
   9 QESIACLL.....E.....-RYRFENLQ...PQLKEIGDLERILARIG.....LRNARPRDLARL
  10 QESIACLL.....E.....-RYRFENLQ...PQLKEIGDLERILARIG.....LRNARPRDLARL
  11 QDTVACLL.....Q.....DY-RFESLQ...PQLKEIGDVERILARIG.....LRNARPRDLARL
  12 QQSIAEIL.....-.....NFDLVDELQ...PYLQLVGDMERILARVA.....LRSARPRDLTRL
  13 LDRVERFV.....R.....EGALREGVR...RLLFRLADLERLATRLE.....LSRASPRDLAAL
  14 LDRVERFV.....R.....EGALREGVR...RLLFRLADLERLATRLE.....LSRASPRDLAAL
  15 LDRVERFV.....R.....EGALREGVR...RLLFRLADLERLATRLE.....LSRASPRDLAAL
  16 LNLVEAFV.....E.....DAELRQTLQe..DLLRRFPDLNRLAKKFQ.....RQAANLQDCYRL
  17 LNLVEAFV.....E.....DAELRQTLQe..DLLRRFPDLNRLAKKFQ.....RQAANLQDCYRL
  18 LNLVEAFV.....E.....DAELRQTLQe..DLLRRFPDLNRLAKKFQ.....RQAANLQDCYRL
  19 LDRVERFV.....R.....EGALREGVR...RLLFRLADLERLATRLE.....LSRASPRDLAAL
  20 LNLVEAFV.....E.....DSELRQSLQe..DLLRRFPDLNRLAKKFQ.....RQAANLQDCYRL
  21 LNLVEAFV.....E.....DSELRQSLQe..DLLRRFPDLNRLAKKFQ.....RQAANLQDCYRL
  22 LNLVEAFV.....E.....DSELRRALQe..DLLRRFPDLNRLAKKFQ.....RQAANLQDCYRL
  23 QQTIGAL-.....-.....-QDTVSELQ...PVLRQVGDLERTPC---.....-ASGAAQPSARS
  24 LKAVERLV.....N.....DRVSLEEMR...NLLSNVRDVERIVSRVE.....YNRSVPRDLVAL
  25 QDSVEFFL.....Q.....QADLRKILK...RQLSCVRDLERLATKIS.....TSLATPKDIGTL
  26 LDAVEDLM.....A.....VPDKVTEVA...DLLKKLPDLERLLSKIHn23ttYSKKKIIDFLSA
  27 LDAIEDLM.....V.....VPDKISEVV...ELLKKLPDLERLLSKIHn23ttYSKKKIIDFLSA
  28 LDAIEDLM.....V.....VPDKISEVV...ELLKKLPDLERLLSKIHn23ttYSKKKIIDFLSA
  29 LDAIEDLM.....V.....VPDKISEVV...ELLKKLPDLERLLSKIHn23ttYSKKKIIDFLSA
  30 LKAVERLV.....N.....DRVSLEEMR...NLLSNVRDVERIVSRVE.....YNRSVPRDLVAL
  31 LDAIEDLM.....V.....VPDKISEVV...ELLKKLPDLERLLSKIHn23ttYSKKKIIDFLSA
  32 QDSVEFFL.....K.....QEPLRKTLK...RHLSCVRDLERLATKIS.....TTLASPKDIGML
  33 QEAVAAL-.....-.....-ESQYKPLQ...CRLKSIADIERIAARIA.....VGNARPRDLAAL
  34 QDAVEFFL.....R.....QVTLRKNIK...TYLCQVRDIERLMTKVT.....TGLAGPRDIGTL
  35 QDAVEFFL.....R.....QVTLRKNIK...TYLCQVRDIERLMTKVT.....TGLAGPRDIGTL
  36 LDAVEDLM.....A.....VPYKVTEVA...DLLKKLPDLERLLSKIHn23ttYSKKKIIDFLSA
  37 QEAVAAL-.....-.....-ESQYKPLQ...CRLKNIADIERIAARIA.....VGNARPRDLASL
  38 QEMVETLM.....S.....HFFEREDLR...ERLKEVYDLERLAGRVA.....FGNVNARDLIQL
  39 QEMVETLM.....S.....HFFEREDLR...ERLKEVYDLERLAGRVA.....FGNVNARDLIQL
  40 LDSVDSLL.....Q.....DITLREQLE...ITFSKLPDLERMLARIH.....SRTIKVKDFEKV
  41 LDSVDSLL.....Q.....DITLREQLE...ITFSKLPDLERMLARIH.....SRTIKVKDFEKV
  42 LDAIEDLM.....V.....VPDKISEVV...ELLKKLPDLERLLSKIHn23ttYSKKKIIDFLSA
  43 QEVVQVFL.....D.....HFFERSDLT...DSLKGVYDIERLASRVS.....FGKTNPKDLLQL
  44 LSAVVFFH.....H.....RPHILKTLR...ATLSCVRDVERLVARVA.....LEKAHGRDLLAL
  45 LNLVEAFV.....M.....DVELRQCLQe..DLLRRFPDLNRLAKKFQ.....RQTANLQDCYRL
  46 QQTIGAL-.....-.....-QDTVSELQ...PVLRQVGDLERTPC---.....-ASGAAQPSARS
  47 LDAVSDVLh....S.....ESSVFEQIE...NLLRKLPDVERGLCSIY.....HKKCSTQEFFLI
  48 LDAVSDVLh....S.....ESSVFEQIE...NLLRKLPDVERGLCSIY.....HKKCSTQEFFLI
  49 LDAVSDVLh....S.....ESSVFEQIE...NLLRKLPDVERGLCSIY.....HKKCSTQEFFLI
  50 LDAVSDVLh....S.....ESSVFEQIE...NLLRKLPDVERGLCSIY.....HKKCSTQEFFLI
  51 QEGVQELK.....E.....NREALLKIR...QILEGMADLERLVSKIS.....SNMATPRELVYL
  52 HAAVGSMI.....-.....DRDLDNKLM...ETFRRLGDMERILTRVA.....LRSARPRDISTL
  53 LDAVSEVLh....S.....ESSVFGQIE...NHLRKLPDIERGLCSIY.....HKKCSTQEFFLI
  54 HNIVQCLL.....E.....SPDTMETLSl..DYLKRIPDILMLTKKLM.....RRKANLQDLFRI
  55 HNIVQCLL.....E.....SPDTMETLSl..DYLKRIPDILMLTKKLM.....RRKANLQDLFRI
  56 LDAVSEVLh....S.....ESSVFGQIE...NHLRKLPDIGRGLCSIY.....HKKCSTQEFFLI
  57 LNITEFFY.....S.....NLGIVTRIR...ELLKNTSDIERCLTRIT.....MNRSSGRDLLSI
  58 QDAVAILRg....E.....NLPYSLEFR...KSLSRLPDMERLIARMFs18edTAKKQVQEFIST
  59 LDVVELIA.....D.....NPVIRDTIW...GFLHKLPDLERLISRVH.....AGRSKPADFVRV
  60 QDAVAILRg....E.....NLPYSLEFR...KSLSRLPDMERLIARMFs18edTAKKQVQEFIST
  61 QQLVEAFA.....N.....DTELRQSMQe..EHLRSIPDLYRLSKRFQ.....RGKATLEDVVRA
  62 LNLVEAFV.....E.....DAELRQTLQe..DLLRRFPDLNRLAKKFQ.....RQAANLQDCYRL
  63 QEAVEELI.....N.....KREVLNEIR...KTLEGMSDLERLVSRIS.....SNMASPRELIHL
  64 HDLVDYLI.....D.....QIELRQMLTs..EYLPMIPDIRRLTKKL-.....NKRGNLEDVLKI
  65 HDLVDYLI.....D.....QIELRQMLTs..EYLPMIPDIRRLTKKL-.....NKRGNLEDVLKI
  66 LDIVQCFV.....E.....EAGLRQDLR...QHLKRISDVERLLRSLE.....RRRGGLQHIIKL
  67 LDSIEVLA.....D.....QPRFTTDVR...DALRRAPDMPRALSRLA.....LGRGGPRDLGAI
  68 LDIVQCFV.....E.....EAGLRQDLR...QHLKRISDVERLLRSLE.....RRRGGLQHIIKL
  69 LDAIECITsei..N.....NSIFFESLN...QMLNHTPDLLRTLNRIM.....YGTTSRKEVYFY
  70 LDAIECITsei..N.....NSIFFESLN...QMLNHTPDLLRTLNRIM.....YGTTSRKEVYFY
  71 HDLVSALV.....E.....DAEARQLLLdddHLLRSIPDIPKLCRRLT.....RGSASLEDVVRI
  72 LDAVEELAf....N.....SNSQVQAIR...KMLYRLPDLEKGLSRIYy13fsKNSYSCFKSALL
  73 LDAVEELAf....N.....SNSQVQAIR...KMLYRLPDLEKGLSRIYy13fsKNSYSCFKSALL
  74 HDLVSALV.....E.....DAEARQLLLdddHLLRSIPDIPKLCRRLT.....RGSASLEDVVRI
  75 QKAIKWLVsp...D.....ASSFMTTAT...ATLKKIPDLDRLLQKIHt23ikTNQKKIAELLAA
  76 LDMVQAFV.....E.....DPELRQGLR...QQLKRISDIDRLTHSLR.....KKSANLQPVVKL
  77 LDAVSEIS.....Ac27peFYLVLSSVL...TAMSRSSDIQRGITRIF.....HRTAKATEFIAV
  78 LEALEELK.....A.....NDDLLQKLR...LEMKSLPDLDKLFSRLLci7aiKPDQRINYVLLL
  79 LEALEELK.....A.....NDDLLQKLR...LEMKSLPDLDKLFSRLLci7aiKPDQRINYVLLL
  80 HNIVQCLL.....E.....SPDTMETLSl..DYLKR------------.....------------
  81 QSAVATFKg....V.....GQDCAAQFR...KDLSRLPDMERLLARLFs17edASKKLLQQFTSA
  82 LDAVSEIS.....Ac27peFYLVLSSVL...TAMSRSSDIQRGITRIF.....HRTAKATEVKIW
  83 LDAVSEIS.....Ac27peFYLVLSSVL...TAMSRSSDIQRGITRIF.....HRTAKATEV-KI
  84 QKCVHYFKqd...W.....NAEVTAKLS...SILGRVKALNSVFQKFQ.....SGTAQLIHWECF
  85 QKCVHYFKqd...W.....NAEVTAKLS...SILGRVKALNSVFQKFQ.....SGTAQLIHWECF
  86 LNLVEAFV.....E.....DAELRQTLQe..DLLRRFPDLNRLAKKFQ.....RQAANLQDCYRL
  87 QDAIGELI.....R.....MPTELQEVR...ALLAPMPDFERNLAQIHl24klYNKQKLQGFMAV
  88 LDCVQELL.....Q.....DEELFFGLQ...SVISRFLDTEQLLSVLVqi9vnAAESKITNLIYL
  89 LDCVQELL.....Q.....DEELFFGLQ...SVISRFLDTEQLLSVLVqi9vnAAESKITNLIYL
  90 LDVIQFFLmp...Q.....NLDMAQMLH...RLLSHIKNVPLILKRMK.....LSHTKVSDWQVL
  91 LDVIQFFLmp...Q.....NLDMAQMLH...RLLSHIKNVPLILKRMK.....LSHTKVSDWQVL
  92 LDIVEALF.....E.....NQTIRQKLRd..SILARMPDCSQLARRL-.....MRKCTLQDLNRF
  93 LDVIQFFLlp...Q.....NLDMAQMLH...RLLGHIKNVPLILKRMK.....LSHTKVSDWQVL
  94 LDVIQFFLlp...Q.....NLDMAQMLH...RLLGHIKNVPLILKRMK.....LSHTKVSDWQVL
  95 LDHVEFFC.....K.....NISLTVTLR...ETFINIWDIERIISRIQ.....MKRYIKKDFLFI
  96 LDVIQFFLlp...Q.....NLDMAQMLH...RLLGHIKNVPLILKRMK.....LSHTKVSDWQVL
  97 LDIVDEFS.....A.....HFIERDTLR...TYLNQVYDIERLVGRVS.....YGNVNARDLIQL
  98 LSLVELMV.....E.....DSILRDALLs..QVLRCCGDMDRLNRKLQ.....RRSIALKDLQSI
  99 LDLVEKFK.....L.....LPELCSKVI...NLLKKSNDTHRILQHLL.....MGRGNSYDLLKM
 100 QEAIEELI.....G.....KPQLKDKLR...RTLSRAHELDRVIAMCIqt9vrESEAKINQIIKL
 101 SESLQELI.....N.....DEDALISIR...SSLKHTCDLEKVFSTFLep6llSQEQEINNIILL
 102 QKCVHYFKqv7kvE.....YRNLWEIFL...NHSKFSPDSEYLSEKIFl96fqSGTAQLIHWECF
 103 LDLVEKFK.....L.....LPELCSKVI...NLLKKSNDTHRILQHLL.....MGRGNSYDLLKM
 104 LNLVEAFV.....E.....DAELRQTLQe..DLLRRFPDLNRLAKKFQ.....RQAANLQDCYRL
 105 LDVVEEFT.....A.....NSESMQITG...QYLHKLPDLERLLGRIKs17kkVLKQRVKAFGQI
 106 LDVVEGFI.....Q.....NCGLGPTTL...GYLQKIPDLERLLGQV-.....------------
 107 LDVVEGFI.....Q.....NCGLGPTTL...GYLQKIPDLERLLGQV-.....------------
 108 LDVVEEFT.....A.....NSESMQITG...QYLHKLPDLERLLGRIKs17kkVLKQRVKAFGQI
 109 --------.....-.....---IGVDVS...PVMIKVVDAAVQKARIG.....LRNARPRDLARL
 110 YSIIRTLLdk...Q.....NAIIFSDLS...QSIKRCPDAFGFINQLR.....SGKSTLGTWSKV
 111 YSIIRTLLdk...Q.....NAIIFSDLS...QSIKRCPDAFGFINQLR.....SGKSTLGTWSKV
 112 QKIVAFFK.....D.....NRDITETLR...TMLKKVNDLSRILQKFS.....FGRGEALELIQM
 113 QKIVAFFK.....D.....NRDITENLR...TMLKKVNDLSRILQKFS.....FGRGEALELIQM
 114 LNLVEAFV.....E.....DAELRQTLQ...-----------------.....------------
 115 QEVLAYLMvc...K.....DDXQVEDXL...HECARXGDXEAVVSKLX.....AERCQVVEFX--


            160       170            180       190            200      
             |         |              |         |              |      
   1 RR.SLQILPELRALLGEEVG.....LPDLSPLKEELEAALVEDPP.....LKVSEGGLIREGYDP
   2 RH.AMQQLPELHSVMSELKQph9thAEPMDELCDLLERAIKENPP.....VVIRDGGVIADGYSA
   3 RR.SLQILPELRALLGEEVG.....LPDLSPLKEELEAALVEDPP.....LKVSEGGLIREGYDP
   4 RH.AFQQLPELRAQLETVDSap9ekMGEFAELRDLLERAIIDTPP.....VLVRDGGVIASGYNE
   5 RH.AFQQLPELRAQLETVDSap9ekMGEFAELRDLLERAIIDTPP.....VLVRDGGVIASGYNE
   6 RH.AFQQLPELRAQLETVDSap9ekMGEFAELRDLLERAIIDTPP.....VLVRDGGVIASGYNE
   7 AS.SLVRLTDLAELAQEGHSpy9tvPPELEELGKYVLAHIVENPP.....LHIREGNLIRSGVNP
   8 AS.SLVRLTDLAELAQEGHSpy9tvPPELEELGKYVLAHIVENPP.....LHIREGNLIRSGVNP
   9 RD.ALAALPDLQNAMTELEAph9ttIGTYPELAELLAKAIIDNPP.....AVIRDGGVIKTGYDA
  10 RD.ALAALPDLQNAMTELEAph9ttIGTYPELAELLAKAIIDNPP.....AVIRDGGVIKTGYDA
  11 RD.ALAALPQLQTALSPLEAph9gnIRTYPELAELLRRAIIDNPP.....AVIRDGGVLKQGYDA
  12 RT.ALEQIPALRAIVQQKTPpf9sqIADFSEQCDLLQRALIETPP.....LLIRDGGVIAEGYNA
  13 RR.SLEILPELKGLLGEEVG.....LPDLSGLLEELRAALVEDPP.....LKVSEGGLIREGYDP
  14 RR.SLEILPELKGLLGEEVG.....LPDLSGLLEELRAALVEDPP.....LKVSEGGLIREGYDP
  15 RR.SLEILPELKGLLGEEVG.....LPDLSGLLEELRAALVEDPP.....LKVSEGGLIREGYDP
  16 YQ.GINQLPNVIQALEKHEGk17dlRSDFSKFQEMIETTLDMD--.....QVENHEFLVKPSFDP
  17 YQ.GINQLPNVIQALEKHEGk17dlRSDFSKFQEMIETTLDMD--.....QVENHEFLVKPSFDP
  18 YQ.GINQLPNVIQALEKHEGk17dlRSDFSKFQEMIETTLDMD--.....QVENHEFLVKPSFDP
  19 RRrSLEILPELEGLLGEEVG.....LPDLSGLLEELRAALVEDPP.....LKVSEGGVIREGYDP
  20 YQ.GINQLPSVIQALEKYEGr17dlRSDFSKFQEMIETTLDMD--.....QVENHEFLVKPSFDP
  21 YQ.GINQLPSVIQALEKYEGr17dlRSDFSKFQEMIETTLDMD--.....QVENHEFLVKPSFDP
  22 YQ.GVKQLPNVIQALEKYQGr17dlRSDFSKFQEKIETTLDMD--.....QVENHEFLVKPSFDP
  23 RP.NASRLPAAAELHAQLETv12kkMGDFAELRDLLERAIIDAPP.....VLVRDGAVIAPGYHE
  24 RE.TLEIIPKLNEVLSTFGVfkk..LAFPEGLVDLLRKAIEDDPV.....GSPGEGKVIKRGFSS
  25 RD.SLLSCTHIADNLQNCALp10liAPPLCSLIKTLSTELIQELP.....LKVSEGNIFANHYHP
  26 LE.GFKVMCKVSGLLEEVAGg21grFPDLTAELQRWDTAFDHEK-.....ARKTGLITPKAGFDS
  27 LE.GFKVMCKIIGIMEEVADg21grFPDLTVELNRWDTAFDHEK-.....ARKTGLITPKAGFDS
  28 LE.GFKVMCKIIGIMEEVADg21grFPDLTVELNRWDTAFDHEK-.....ARKTGLITPKAGFDS
  29 LE.GFKVMCKIIGIMEEVADg21grFPDLTVELNRWDTAFDHEK-.....ARKTGLITPKAGFDS
  30 RE.TLEIIPKLNEVLSTFGVfkk..LAFPEGLVDLLRKAIEDDPV.....GSPGEGKVIKRGFSS
  31 LE.GFKVMCKIIGIMEEVADg21grFPDLTVELNRWDTAFDHEK-.....ARKTGLITPKAGFDS
  32 RD.SLLSCMHIAHDLQSYTLp10liSSSLKSLIEALSTDLLQELP.....LKVSEGNIFADHYHQ
  33 RD.SLFALSEIELSAECSSLlg7avFPENLSTAEQLRQAILPEPS.....VWLKDGNVINHGFHP
  34 RD.SFSAGAQIYEQLASATLp10slDTKLASLIALLSKSLNGDLP.....LRVSDGNIFVDEFHN
  35 RD.SFSAGAQIYEQLASATLp10slDTKLASLIALLSKSLNGDLP.....LRVSDGNIFVDEFHN
  36 LE.GFKVMCKVSGLLEEVAGg21grFPDLTAELQRWDTAFDHEK-.....ARKTGLITPKAGFDS
  37 RD.SLFELAQIDLSANGSSLle7avFPENLSTAEQLRQAILPEPS.....VWLKDGNVINHGFHP
  38 KE.SLKQVPGIKQLVASLAHdk9krIDPCGDVLELLEEALYENPP.....LSVKEGNLIKDGYNQ
  39 KE.SLKQVPGIKQLVASLAHdk9krIDPCGDVLELLEEALYENPP.....LSVKEGNLIKDGYNQ
  40 IT.AFETIIELQDSLKNNDL.....KGDVSKYISSFPEGLVEAVKs10qkAINENIIVPQRGFDI
  41 IT.AFETIIELQDSLKNNDL.....KGDVSKYISSFPEGLVEAVKs10qkAINENIIVPQRGFDI
  42 LE.GFKVMCKIIGIMEEVADg21grFPDLTVELNRWDTAFDHEK-.....ARKTGLITPKAGFDS
  43 AT.TLSSVPRIRAILEGMEQpt9aqLDAIPELESLISAAIAPEAP.....HVITDGGIIRTGFDE
  44 KE.SLRAILTFRSLERESPFp10gdTPVLQELYGLLEQSIKEDCP.....VTLSDGNLIKRGFSA
  45 YQ.AVNHLPTVVQAIEKYEGt17dlSSDFSKFQEMIETTLDMD--.....QVENHEFLVKASFDP
  46 RP.NASRLPAAAELHAQLET.....VDSAPVQRCVKKWAISPSCAt11rrRYWSRRRVIAPGYHE
  47 VK.SLCQLKSELQALMPAVNs11alIVELLSPVEHYLKVLNGPAA.....KVGDKTELFKDLSDF
  48 VK.SLCQLKSELQALMPAVNs11alIVELLSPVEHYLKVLNGPAA.....KVGDKTELFKDLSDF
  49 VK.SLCQLKSELQALMPAVNs11alIVELLSPVEHYLKVLNGPAA.....KVGDKTELFKDLSDF
  50 VK.SLCQLKSELQALMPAVNs11alIVELLSPVEHYLKVLNGPAA.....KVGDKTELFKDLSDF
  51 KN.SLKKVEELRLLLLELKApi9qnFEDTKKIINDIEKTLVEDPP.....LHVKEGGLIREGVNA
  52 RD.SLSLLPRLRELLNASDSpr9aeLGEHDSTASLLVKAVAEQPP.....LKLTDGGVIASEYDV
  53 VK.TLYHLKSEFQAIIPAVNs14leIPELLSPVEHYLKILNEQAA.....KVGDKTELFKDLSDF
  54 YQ.VILRTPKILKVLHELDNs14sfLKDLTGLKQMVEQVVDFE--.....AIERGEYLVKASFDS
  55 YQ.VILRTPKILKVLHELDNs14sfLKDLTGLKQMVEQVVDFE--.....AIERGEYLVKASFDS
  56 VK.TLYHLKSEFQAIIPAVNs14leIPELLSPVEHYLKILNEQAA.....KVGDKTELFKDLSDF
  57 KY.TLETAKTIKGLFSESYGl13kpLSGDAELYNLIHMSIREDAP.....NNLNDGGIIKYEFHP
  58 LR.GCETMAEACSSLRAILKh16qsLPNISSSIKYFKDAFDWVE-.....AHNSGRVIPHEGADE
  59 LE.GFQRINSAFDQLREEFMe14qsAPNMKEELEAWTRAFNWQK-.....ASEEGVFEPEIGFEA
  60 LR.GCETMAEACSSLRAILKh41qsLPNISSSIKYFKDAFDWVE-.....AHNSGRVIPHEGADE
  61 YQ.VVIRLPGFIGTLEGVMDe18elSDSLVKLQEMVETTVDLD--.....ALDNHEFIIKPEFDD
  62 YQ.GINQLPNVIQALEKHEGk17dlRSDFSKFQEMIETTLDMD--.....QVENHEFLVKPSFDP
  63 KN.SLRKAEELRKILSLLDSei9gsLLNLNKVADLIDKTLVDDPP.....LHVKEGGLIKPGVNA
  64 YQ.FSKRIPEIVQVFTSFLEd23hhVEPLSKFEEMVETTVDLDA-.....YEENNEFMIKVEFNE
  65 YQ.FSKRIPEIVQVFTSFLEd23hhVEPLSKFEEMVETTVDLDA-.....YEENNEFMIKVEFNE
  66 YQ.SAIRLPFIKTAMQQYTGe19sdQDHLGKFIDLVECSVDLD--.....QLENGEYMISSNYDT
  67 QA.GMRAAAAISALLSGAELs11aiAALPGELLARLDATLAEELP.....LLKRDGGFVREGASA
  68 YQ.STIRLPFIKTAMQQYTGe19sdQDHLGKFIDLVECSVDLD--.....QLENGEYMISSSYDT
  69 LK.QITSFVDHFKMHQSYLSe29lsTTQLPHFLTMINVSAVMEKNsdk..QVMDFFNLNNYDCSE
  70 LK.QITSFVDHFKMHQSYLSe29lsTTQLPHFLTMINVSAVMEKNsdk..QVMDFFNLNNYDCSE
  71 YQ.MAKALPKIVTVLDSLTSe17nhCKNLEKLIELVETTIDLE--.....ALDSHQYIIRAEFDE
  72 RR.LIQQLPSISSIIDHFLGmf...DQKEAENNNKVDMFKDIDNF.....DLSEEPNDVDYELAQ
  73 RR.LIQQLPSISSIIDHFLGmf...DQKEAENNNKVDMFKDIDNF.....DLSEEPNDVDYELAQ
  74 YQ.MAKALPKIVTVLDSLTSe17nhCKNLEKLIELVETTIDLE--.....ALDSHQYIIRAEFDE
  75 ID.GFKLCNKLRKEYIKVQKe17qeMEEVDENIYFFEKMFDRST-.....AMKDGKIVPNAGCDE
  76 YQ.SCSRIPYIKGILQQYNGq19maKNRFGRFSSLVETAIDLA--.....QLENGEYRISPLYSS
  77 ME.AILLAGKQIQRLGIKQDs28vvVDNAGKLLSALNKEAAVRGD.....LL--DILITSSDQFP
  78 KE.TLQSVKSLKDALNDQLIq13fnNDAIMEIEKLINSCINEDCVwa7iqLLNQRSYAVKSDSNG
  79 KE.TLQSVKSLKDALNDQLIq13fnNDAIMEIEKLINSCINEDCVwa7iqLLNQRSYAVKSDSNG
  80 --.-----------------.....------LKQMVEQVVDFE--.....AIERGEYLVKASFDS
  81 LC.GCQQMFHACSSISTLICs15kgLSNISSILDRFRDAFDWSD-.....ADRNGRFIPYEGCDP
  82 PV.LCPLMYVPVSSSPGLRVl58vvVDNAGKLLSALNKEAAVRGD.....LL--DILITSSDQFP
  83 WP.VLCPLMYVPGSSSPGLRv59vvVDNAGKLLSALNKEAAVRGD.....LL--DILITSSDQFP
  84 VS.TVNALVEILNIIRQTPIs10dlLREVSEIAVIAGSIINFAE-.....SKIQGRVTVMNGIDE
  85 VS.TVNALVEILNIIRQTPIs10dlLREVSEIAVIAGSIINFAE-.....SKIQGRVTVMNGIDE
  86 YQ.GINQLPNVIQALEKHEGk17dlRSDFSKFQEMIETTLDMD--.....QVENHEFLVKPSFDP
  87 LK.GFNDLTKLPTMFHQCKTt15gsFPDLSKELQYFATAFDHDA-.....AAKTGVIAPQAGMDA
  88 KH.TLELVDPLKIAMKNCNTp11leDKRFGIILEKIKTVINDDARym7lnMRTQKCYAVRSNINE
  89 KH.TLELVDPLKIAMKNCNTp11leDKRFGIILEKIKTVINDDARym7lnMRTQKCYAVRSNINE
  90 YK.TVYSALGLRDACRSLPQs12efSDDLHHIASLIGKVVDFEE-.....SLAENRFTVLPNIDP
  91 YK.TVYSALGLRDACRSLPQs12efSDDLHHIASLIGKVVDFEE-.....SLAENRFTVLPNIDP
  92 YQ.AATLLETVEMQLIQLSEa19eiLKKVERFQVLCDEFFDFDY-.....EKENKEIRVRVDFVP
  93 YK.TVYSALGLRDACRSLPQs12efSDDLHHIASLIGKVVDFEG-.....SLAENRFTVLPNIDP
  94 YK.TVYSALGLRDACRSLPQs12efSDDLHHIASLIGKVVDFEG-.....SLAENRFTVLPNIDP
  95 EK.ALSVFFTVKKLFDKHNFdy9feEDSISKVYFLINSAISSAPD.....------ELIKRGYDL
  96 YK.TVYSALGLRDACRSLPQs12efSDDLHHIASLIGKVVDFEG-.....SLAENRFTVLPNIDP
  97 KH.SISEIPNIKALLNSMNQnt8nqLEPLDDLLDILEQSLVEEPP.....ISVKDGGLFKVGFNT
  98 LT.FVNTIPRAVQVLRTHQGg14apLEDINEHFSNLRILITATVD.....LSDENTTRINPEFDD
  99 AD.NFSITKEIHSLLSPLESs10lnMHPHDELKQLINNAVDENAL.....MK-------------
 100 MH.TLKVIQGIRTLLHSAKMk13lkDPRFDQIMNILVEKVDDSLLdg8lhLQNTKCYAIRHFVAV
 101 KT.VLQNTFVIRKSIQNVSSh11leHENVQHLLAIINEYIRNDCQwa7teLANQRANAVKSGVNG
 102 VS.TVNALVEILNIIRQTPIs10dlLREVSEIAVIAGSIINFAE-.....SKIQGRVTVMNGIDE
 103 AD.NFSITKEIHSLLSPLESs10lnMHPHDELKQLINNAVDENAL.....MK-------------
 104 YQ.GINQLPNVIQALEK---.....--------------------.....---------------
 105 VK.GFRSGIDLLLALQKESNm16vgKSGLELFLSQFEAAIDSDFP.....N--------------
 106 --.------------RSTVG.....LSSLLQLPFIGEKIIK----.....KRIKTFIMLINGLRN
 107 --.------------RSTVG.....LSSLLQLPFIGEKIIK----.....KRIKTFIMLINGLRN
 108 VK.GFRSGIDLLLALQKESNm16vgKSGLELFLSQFEAAIDSDFP.....N--------------
 109 RD.ALGALPELQNAMTELEAph9aiTGTYPELASLLERAIIDNPP.....AVIRDGGVLKAGYDN
 110 AS.FLEKGIAIFQLVSSLKLg16vdISALKECLRKVETVIDFDT-.....SRDTKTLTINTGVDN
 111 AS.FLEKGIAIFQLVSSLKLg16vdISALKECLRKVETVIDFDT-.....SRDTKTLTINTGVDN
 112 AR.SLEVSREIRKYLLNNTSl23nlIDDILKFLNEEELAKSQDAKq23deIFELRDFIVNPSFNT
 113 AR.SLEVSREIRKYLLNNTSl23nlIDDILKFLNEEELAKSQDAKq23deIFELRDFIVNPSFNT
 114 --.-----------------.....--------------------.....---------------
 115 --.-----------------.....--------------------.....---------------


       210        220       230                 240       250          
        |          |         |                   |         |          
   1 DLDALR.AAHREGVAYFLELEERERERT...G..IP.....TLKVGYNAVFGYYLEVTRPYY...
   2 ELDEWR.DLANGATEFLERLEAEERDRH...G..ID.....TLKVGYNNVHGFYIQVSRGQS...
   3 DLDALR.AAHREGVAYFLELEERERERT...G..IP.....TLKVGYNAVFGYYLEVTRPYY...
   4 ELDEWR.ALADGATDYLERLEVRERERT...G..LD.....TLKVGFNAVHGYYIQISRGQS...
   5 ELDEWR.ALADGATDYLERLEVRERERT...G..LD.....TLKVGFNAVHGYYIQISRGQS...
   6 ELDEWR.ALADGATDYLERLEVRERERT...G..LD.....TLKVGFNAVHGYYIQISRGQS...
   7 TLDEMR.QSLEDDNQWLANLEVTEREKT...G..IA.....NLKVGYNKAFGYYLSLPRSKS...
   8 TLDEMR.QSLEDDNQWLANLEVTEREKT...G..IA.....NLKVGYNKAFGYYLSLPRSKS...
   9 ELDELQ.ALSENAGQFLMDLEAREKART...G..LP.....NLKVGYNRIHGYFIELPRVQA...
  10 ELDELQ.ALSENAGQFLMDLEAREKART...G..LP.....NLKVGYNRIHGYFIELPRVQA...
  11 ELDELL.SLSENAGQFLMDLEAREKART...G..LP.....NLKVGYNRIHGYYIELPRVQA...
  12 ELDEWR.MLSDGATQYLENLEKREREST...G..ID.....TLKIGFNAVHGYYIQISQGQA...
  13 DLDALR.RAHAEGVAYFLDLEAREKERT...G..IP.....TLKVGYNAVFGYYLEVTRPYY...
  14 DLDALR.RAHAEGVAYFLDLEAREKERT...G..IP.....TLKVGYNAVFGYYLEVTRPYY...
  15 DLDALR.RAHAEGVAYFLDLEAREKERT...G..IP.....TLKVGYNAVFGYYLEVTRPYY...
  16 NLSELR.EIMNDLEKKMQSTLISAARDL...G..LDpgk..QIKLDSSAQFGYYFRVTCKEE...
  17 NLSELR.EIMNDLEKKMQSTLISAARDL...G..LDpgk..QIKLDSSAQFGYYFRVTCKEE...
  18 NLSELR.EIMNDLEKKMQSTLISAARDL...G..LDpgk..QIKLDSSAQFGYYFRVTCKEE...
  19 DLDALR.RAHADPVAYFLDLEVREKEST...G..IP.....TLKVGYNAVFGYYLEVTRPYY...
  20 NLSELR.EVMDGLEKKMQSTLINAARGL...G..LDpgk..QIKLDSSAQFGYYFRVTCKEE...
  21 NLSELR.EVMDGLEKKMQSTLINAARGL...G..LDpgk..QIKLDSSAQFGYYFRVTCKEE...
  22 NLSELR.EVMDGLEKKMQSTLISAARGL...G..LDpgk..QIKLDSSAQFGYYFRVTCKEE...
  23 ELDEWR.ALADGATDYLDRLEIRERERT...G..LD.....TLKVGYNAVHGYYIQISRGQS...
  24 ELDEYR.DLLEHAEERLKEFEEKERERT...G..IQ.....KLRVGYNQVFGYYIEVTKANL...
  25 DLLRLR.NIKENSKSWILEYQERIRNET...G..IK.....KLKVCYAQALGYYIEVASNLA...
  26 DYDQAL.ADIRENEQSLLEYLDKQRSRL...G..CK.....SIVYWGIGRNRYQLEIPENFA...
  27 DYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR.....TIVYWGIGRNRYQLEIPENFT...
  28 DYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR.....TIVYWGIGRNRYQLEIPENFT...
  29 DYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR.....TIVYWGIGRNRYQLEIPENFT...
  30 ELDEYR.DLLEHAEERLKEFEEKERERT...G..IQ.....KLRVGYNQVFGYYIEVTKANL...
  31 DYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR.....TIVYWGIGRNRYQLEIPENFT...
  32 DLLRLR.NIKTNSKSWILEYQERIRQET...G..IK.....KLKVCYAQALGYYIEVASSFA...
  33 ELDELR.RIQNHGDEFLLDLEAKERERT...G..LS.....TLKVEFNRVHGFYIELSKTQA...
  34 DLKRLR.HNQEHSQEWIWEYQERIRKET...G..IK.....KLKICFAQALGYYIEVSSEFA...
  35 DLKRLR.HNQEHSQEWIWEYQERIRKET...G..IK.....KLKICFAQALGYYIEVSSEFA...
  36 DYDQAL.ADIRENEQSLLEYLDKQRSRL...G..CK.....SIVYWGIGRNRYQLEIPENFA...
  37 ELDELR.RIQNHGDEFLLDLEAKERERT...G..LS.....TLKVEFNRVHGFYIELSKTQA...
  38 KLDEYR.DASRNGKDWIARLEQQEREYT...G..IR.....SLKVGFNKVFGYYIEVTKANL...
  39 KLDEYR.DASRNGKDWIARLEQQEREYT...G..IR.....SLKVGFNKVFGYYIEVTKANL...
  40 EFDKSM.DRIQELEDELMEILMTYRKQF...K..CS.....NIQYKDSGKEIYTIEIPISAT...
  41 EFDKSM.DRIQELEDELMEILMTYRKQF...K..CS.....NIQYKDSGKEIYTIEIPISAT...
  42 DYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR.....TIVYWGIGRNRYQLEIPENFT...
  43 TLDKYR.CVLREGTSWIAEIEAKERENS...G..IS.....TLKIDYNKKDGYYFHVTNSQL...
  44 SLDELH.RVRDNANEILKQYLAEERERT...G..IG.....TLKMKYNRMLGHFLEVSKGHL...
  45 NLTELR.EKMDELEKNMQGALGGAAREL...G..LDagk..SIKLESNSQIGHYFRVTCKEE...
  46 ELDEWR.ALADGATDYLDRLEIRERERT...G..LD.....TLKVGYNAVHGYYIQISRGQS...
  47 PLIKKRkNEIQEVIHSIQMRLQEFRKIL...K..LP.....SLQYVTVSGQEFMIEIKNSAV...
  48 PLIKKRkNEIQEVIHSIQMRLQEFRKIL...K..LP.....SLQYVTVSGQEFMIEIKNSAV...
  49 PLIKKRkNEIQEVIHSIQMRLQEFRKIL...K..LP.....SLQYVTVSGQEFMIEIKNSAV...
  50 PLIKKRkNEIQEVIHSIQMRLQEFRKIL...K..LP.....SLQYVTVSGQEFMIEIKNSAV...
  51 YLDELR.FIRDNAETYLREYEKKLRQET...G..IQ.....SLKIGYNKVMGYYIEVTKPNL...
  52 ELDELR.KLSNNADQFLIDLETRERESS...G..IS.....TLKVGYNRVHGYYIEISKGQA...
  53 PLIKKRkDEIQGVIDEIRMHLQEIRKIL...K..NP.....SAQYVTVSGQEFMIEIKNSAV...
  54 RLMELQ.QMMTELYSKMEELQFKCSQEL...N..LDgkn..QVKLESVAKLGHHFRITVKDD...
  55 RLMELQ.QMMTELYSKMEELQFKCSQEL...N..LDgkn..QVKLESVAKLGHHFRITVKDD...
  56 PLIKKRkDEIQGVIDEIRMHLQEIRKIL...K..NP.....SAQYVTVSGQEFMIEIKNSAV...
  57 KIAQLN.DLINNKKLHVEKLKDQYRKET...R..IE.....SLKISHNNVLGFFIDITPKNV...
  58 EYDCAC.KTVEEFESSLKKHLKEQRKLL...G..DA.....SINYVTVGKDEYLLEVPESLS...
  59 EYDTSQ.KYQSELKNELYALLEQYKKQL...R..CS.....SLNFKNIGKEVYQVEVPSDV-...
  60 EYDCAC.KTVEEFESSLKKHLKEQRKLL...G..DA.....SINYVTVGKDEYLLEVPESLS...
  61 SLRIIR.KKLDRLRTDMDNEFAEAAEDL...G..QErek..KIFLENHKVHGWCMRLTRTEA...
  62 NLSELR.EIMNDLEKKMQSTLISAARDL...G..LDpgk..QIKLDSSAQFGYYFRVTCKE-...
  63 YLDELR.FIRENAEKLLKEYEKKLKKET...G..IQ.....SLKIGYNKVMGYYIEVTKANV...
  64 ELGKIR.SKLDTLRDEIHSIHLDSAEDL...G..FDpdk..KLKLENHHLHGWCMRLTRNDA...
  65 ELGKIR.SKLDTLRDEIHSIHLDSAEDL...G..FDpdk..KLKLENHHLHGWCMRLTRNDA...
  66 KLASLK.DQKELLEQQIHELHKKTAIEL...D..LQvdk..ALKLDKAAQFGHVFRITKKEE...
  67 ELDEMR.ALRDQSRRVIAGLQLQYCEET...G..IK.....SLKIKHNNVLGYFIEVTAGNA...
  68 KLASLK.DQKELLEQQIHELHKKTAIEL...D..LQvdk..ALKLDKAAQFGHVFRITKKEE...
  69 GIIKIQ.RESESVRSQLKEELAEIRKYL...K..RP.....YLNFR--DEVDYLIEVKNSQI...
  70 GIIKIQ.RESESVRSQLKEELAEIRKYL...K..RP.....YLNFR--DEVDYLIEVKNSQI...
  71 ELLDLR.QRLDELQHSIFEEHKRVGSDL...H..QDtek..KLHLEQHHLYGWCLRLTRTEA...
  72 EIRELK.MSILMVRTEMDFHLQELRDYL...E..YP.....NLEFSIWGNVKFCIEVSKGC-...
  73 EIRELK.MSILMVRTEMDFHLQELRDYL...E..YP.....NLEFSIWGNVKFCIEVSKGC-...
  74 ELLDLR.QRLDELQHSIFEEHKRVGSDL...H..QDtek..KLHLEQHHLYGWCLRLTRTEA...
  75 EYDEAL.NRVKEALNELNDYKDSVAKKY...S..CS.....-IKFVDSGKVKYLLEMPEN--...
  76 DLGVLK.DELSVVENHINNLHVDTASDL...D..LSvdk..QLKLEK-GSLGHVFRMSKKEE...
  77 ELAEAR.QAVLVIREKLDSSIASFRKKL...A..IR.....NLEFLQVSGITHLIELPVD--...
  78 LLDVSR.QIYKEVKEEFFREVEDLTAKN...K..IN.....-LDHNYDSARGFYLRIKRQEF...
  79 LLDVSR.QIYKEVKEEFFREVEDLTAKN...K..IN.....-LDHNYDSARGFYLRIKRQEF...
  80 RLMELQ.QMMTELYSKMEELQFKCSQEL...N..LDgkn..QVKLESVAKLGHHFRITVKDD...
  81 EFDATC.NAIEEIKSSLKEYLKEQRKLL...R..PA.....SVNYVNVGKDMYLIEVPESLG...
  82 ELAEAR.QAVLVIREKLDSSIASFRKKL...A..IR.....NLEFLQVSGITHLIELPVD--...
  83 ELAEAR.QAVLVIREKLDSSIASFRKKL...A..IR.....NLEFLQVSGITHLIELPVD--...
  84 ELDEIR.DTYENMPMVLTAIAKQEEARL...G..LPpys..NVACVYIPLVGFVLSVPRDY-...
  85 ELDEIR.DTYENMPMVLTAIAKQEEARL...G..LPpys..NVACVYIPLVGFVLSVPRDY-...
  86 NLSELK.---------------------...-..--.....---------------------...
  87 EYDAAM.DSIGEVEKRLKTYLVEQERHF...G..CR.....-ITYFGSDKKRYQLDVPESHA...
  88 FLDIAR.RTYTEIVDDIAGMISQLGEKY...S..LP.....-LRTSFSSARGFFIQMTTDCIalp
  89 FLDIAR.RTYTEIVDDIAGMISQLGEKY...S..LP.....-LRTSLSSVRGFFIQMTTDCIalp
  90 DIDAKK.RRLIGLPSFLTEVAQKELENL...DsrIP.....SCSVIYIPLIGFLLSIPR---...
  91 DIDAKK.RRLIGLPSFLTEVAQKELENL...DsrIP.....SCSVIYIPLIGFLLSIPR---...
  92 EIQEIS.EKLEQMERVAEKLRKKYSAKF...E..CD.....NLKLDKNSQYGFYFRVTLKEE...
  93 EIDEKK.RRLMGLPSFLTEVARKELENL...DsrIP.....SCSVIYIPLIGFLLSIPR---...
  94 EIDEKK.RRLMGLPSFLTEVARKELENL...DsrIP.....SCSVIYIPLIGFLLSIPR---...
  95 KLDNLK.DLKINANKYIDQYLESERLLS...K..IN.....NLKIRKTNNRGLFFEVTKSNY...
  96 EIDEKK.RRLMGLPSFLTEVARKELENL...DsrIP.....SCSVIYIPLIGFLLSIPR---...
  97 QLDE--.---------------------...-..--.....---------------------...
  98 ELMELE.EQRKSVVKAIESEHQRVMKVY...G..WTek...QLKCEYHTTYGYVFRVTRKED...
  99 -----Q.KINEEEETEVIAQEAEEILQD...E..NA.....QVEIVKKS-----LSSEFDIR...
 100 QLDLAR.QTYEEIIRNVEETGAREIAEYfh.G..NS.....SVRLSFSQSRGFHYTFVTRQA...
 101 LLDVSR.RIRETLLEEVSELVAKLSEEL...E..IF.....-MEYRFEISRGFFIKIKGNNT...
 102 ELDEIR.DTYENMPMVLTAIAKQEEARL...G..LPpys..NVACVYIPLVGFVLSVPRDY-...
 103 -----Q.KINEEEETEVIAQEAEEILQD...E..NA.....QVEIVKKS-----LSSEFDIR...
 104 ------.---------------------...-..--.....---------------------...
 105 ------.---------------------...-..--.....---------------------...
 106 GIDLLN.DLQRADHGILALY--------...-..--.....--KIVDIPSLSYLPELIHKFE...
 107 GIDLLN.DLQRADHGILALY--------...-..--.....--KIVDIPSLSYLPELIHKFE...
 108 ------.---------------------...-..--.....---------------------...
 109 ELDEML.AISENAGQFLIDLEAREKART...G..LA.....NLKVGYNRVHGYFIELPTKQA...
 110 RLDECR.NIYNHLEGILLDVARETQIFLlnt-..--m14ekLVNAVYIPQLGYLVTISVLME...
 111 RLDECR.NIYNHLEGILLDVARETQIFLlnt-..--m14ekLVNAVYIPQLGYLVTISVLME...
 112 KLRKLH.DTYQGVWQ-------------...-..--.....---------------------...
 113 KLRKLH.DTYQGVWQ-------------...-..--.....---------------------...
 114 ------.---------------------...-..--.....---------------------...
 115 ------.---------------------...-..--.....---------------------...


       260                270          280       290       300
        |                  |            |         |         |
   1 .ERV.....PKE....YRPVQTLKD...RQRYTLPEMKEKEREVYRLEALIRRREE
   2 .HLV.....PPH....YVRRQTLKN...AERYIIEELKQHEDKVLNSKSRALALE-
   3 .ERV.....PKE....YRPVQTLKD...RQRYTLPEMKEKEREVYRLEALIRRREE
   4 .HLA.....PIN....YMRRQTLKN...AERYIIPELKEYEDKVLTSKGKALALE-
   5 .HLA.....PIN....YMRRQTLKN...AERYIIPELKEYEDKVLTSKGKALALE-
   6 .HLA.....PIN....YMRRQTLKN...AERYIIPELKEYEDKVLTSKGKALALE-
   7 .EQA.....PDN....YIRKQTLVN...EERYITPELKERETRILTAQADLNQLE-
   8 .EQA.....PDN....YIRKQTLVN...EERYITPELKERETRILTAQADLNQLE-
   9 .EQA.....PAD....YIRRQTLKG...AERFITPELKAFEDKALSAQSRALARE-
  10 .EQA.....PAD....YIRRQTLKG...AERFITPELKAFEDKALSAQSRALARE-
  11 .EQA.....PAD....YIRRQTLKG...AERFITPELKAFEDKALSAKSRALARE-
  12 .HKA.....PIH....YVRRQTLKN...AERYIIPELKEYEDKVLKSKGAALALE-
  13 .EKV.....PQE....YRPVQTLKD...RQRYTLPEMKERERELYRLEALIKRREE
  14 .EKV.....PQE....YRPVQTLKD...RQRYTLPEMKERERELYRLEALIKRREE
  15 .EKV.....PQE....YRPVQTLKD...RQRYTLPEMKERERELYRLEALIKRREE
  16 .KVLrn...NKN....FSTVDIQKN...GVKFTNSKLTSLNEEYTKNKTEYEEAQD
  17 .KVLrn...NKN....FSTVDIQKN...GVKFTNSKLTSLNEEYTKNKTEYEEAQD
  18 .KVLrn...NKN....FSTVDIQKN...GVKFTNSKLTSLNEEYTKNKTEYEEAQD
  19 .EKV.....PQE....YRPVQTLKD...RQRYTLPEMKERERELYRLEALIKRREE
  20 .KVLrn...NKN....FSTVDIQKN...GVKFTNSELSSLNEEYTKNKGEYEEAQD
  21 .KVLrn...NKN....FSTVDIQKN...GVKFTNSELSSLNEEYTKNKGEYEEAQD
  22 .KVLrn...NKN....FSTVDIQKN...GVKFTNSELSSLNEEYTKNKGEYEEAQD
  23 .HLA.....PIN....YVRRQTLKN...AERYIIPELKEYEDKVLTSKGKALALE-
  24 .DKI.....PDD....YERKQTLVN...SERFITPELKEFETKIMAAKERIEELE-
  25 .PQL.....PKE....FIRRQSRLH...AERFTTQELQQFQDEVFSVEDKLQTLE-
  26 .TRNl....PEE....YELKSTKKG...CKRYWTKTIEKKLANLINAEER------
  27 .TRNl....PEE....YELKSTKKG...CKRYWTKTIEKKLANLINAEE-------
  28 .TRNl....PEE....YELKSTKKG...CKRYWTKTIEKKLANLINAEE-------
  29 .TRNl....PEE....YELKSTKKG...CKRYWTKTIEKKLANLINAEE-------
  30 .DKI.....PDD....YERKQTLVN...SERFITPELKEFETKIMAAKERIEELE-
  31 .TRNl....PEE....YELKSTKKG...CKRYWTKTIEKKLANLINAEE-------
  32 .PQL.....PKE....FIRRQSRLH...AERFTTQELQQFQDEVFSVEDKLQTLE-
  33 .EQA.....PAD....YQRRQTLKN...AERFITPELKAFEDKVLTAQEQALALE-
  34 .PQL.....PKD....FIRRQSRLH...AERFTTIELQQFQDDMSNISEKLQTLE-
  35 .PQL.....PKD....FIRRQSRLH...AERFTTIELQQFQDDMSNISEKLQTLE-
  36 .TRNl....PEE....YELKSTKKG...CKRYWTKTIEKKLANLINAEER------
  37 .EQA.....PAD....YQRRQTLKN...AERFITPELKAFEDKVLTAQEQALALE-
  38 .HLL.....EEGr...YERNETLTN...AERYITPELKEKEALILEAENNICELE-
  39 .HLL.....EEGr...YERNETLTN...AERYITPELKEKEALILEAENNICELE-
  40 .KNV.....PSN....WVQMAANKT...YKRYYSDEVRALARSMAEAKEIHKTLEE
  41 .KNV.....PSN....WVQMAANKT...YKRYYSDEVRALARSMAEAKEIHKTLEE
  42 .TRNl....PEE....YELKSTKKG...CKRYWTKTIEKKLANLINAEE-------
  43 .GNV.....PAH....FFRKATLKN...SERFGTEELARIEGDMLEAREKSANL--
  44 .SAV.....PAH....FIRRRSLSN...ADRFTTEQLSELEAKLARAREGLVSFE-
  45 .KALrn...NKK....FTTIDIQKN...GVRFTNSKLSSLSEEYMRNREEYEEAQ-
  46 .HLA.....PIN....YVRRQTLKN...AERYIIPELKEYEDKVLTSKGKALALE-
  47 .SCI.....PAD....WVKVGSTKA...VSRFHPPFIVESYRRLNQLREQ------
  48 .SCI.....PAD....WVKVGSTKA...VSRFHPPFIVESYRRLNQLREQ------
  49 .SCI.....PAD....WVKVGSTKA...VSRFHPPFIVESYRRLNQLREQ------
  50 .SCI.....PAD....WVKVGSTKA...VSRFHPPFIVESYRRLNQLREQ------
  51 .KYV.....PSY....FRRRQTLSN...SERFTTEELQRLEEKILSAQTRINDLE-
  52 .DKA.....PVH....YTRRQTLTN...AERYITEELKAFEDKVLSARDRALVRE-
  53 .SCI.....PTD....WVKVGSTKA...VSRFHSPFIVENYRHLNQLREQ------
  54 .SVLrk...NKN....YRIVDVIKG...GVRFTSDKLEGYADEFASCRTRYEE---
  55 .SVLrk...NKN....YRIVDVIKG...GVRFTSDKLEGYADEFASCRTRYEE---
  56 .SCI.....PTD....WVKVGSTKA...VSRFHSPFIVENYRHLNQLREQ------
  57 .NKIl....DPK....FIHRQTTIN...SVRYTTYELQNLENELVNAQTLVIRLE-
  58 .GSV.....PHD....YELCSSKKG...VSRYWTPTIKKLLKELSQAKSE------
  59 .-KV.....PVN....WCKMSGTKK...TNRYYNDELRKKIKKLLEAEEL------
  60 .GSV.....PHD....YELCSSKKG...VSRYWTPTIKKLLKELSQAKSE------
  61 .GCIrn...NSR....YLECSTQKN...GVYFTTKTLQALRREFDQLSQNYN----
  62 .---.....---....---------...----------------------------
  63 .KYV.....PEH....FRRRQTLSN...AERYTTEELQRLEEKILSAQTRINELE-
  64 .KEL.....RKHkk..YIELSTVKA...GIFFSTKQLKSIANETNILQKEYD----
  65 .KEL.....RKHkk..YIELSTVKA...GIFFSTKQLKSIANETNILQKEYD----
  66 .PKI.....RKKlttqFIVLETRKD...GVKFTNTKLKKLGDQYQSVVDDYRSCQ-
  67 .GSMtd6agRAR....FIHRQTMAN...AMRFTTTELAELETKIANAADRALAIE-
  68 .PKI.....RKKlttqFIVLETRKD...GVKFTNTKLKKLGDQYQSVVDDYRSCQ-
  69 .KDL.....PDD....WIKVNNTKM...VSRFTTPRTQKLTQKLEYYKDLL-----
  70 .KDL.....PDD....WIKVNNTKM...VSRFTTPRTQKLTQKLEYYKDLL-----
  71 .GCLrgr..SSH....YTELSTQKN...GVYFTTKRLHSLNNSYMDHQKS------
  72 .KKI.....PPD....WIKLSSTRS...LFRFHTPKIQSLLIELSSHEEN------
  73 .KKI.....PPD....WIKLSSTRS...LFRFHTPKIQSLLIELSSHEEN------
  74 .GCLrgr..SSH....YTELSTQKN...GVYFTTKRLHSLNNS-------------
  75 .TKV.....SSS....FELKSRRKG...FIRYSTPDSEQLVAALDAVEKE------
  76 .QKV.....RKKltgsYLIIETRKD...GVKFTNSKLKNLSDQYQALFGEYTSCQ-
  77 .SKV.....PMN....WVKVNSTKK...TIRYHPPEIVAGLDEL------------
  78 .TDDvatl.PDV....FISRTIKKN...YIECTTLNIIKKNARLKEVMEEI-----
  79 .TDDvatl.PDV....FISRTIKKN...YIECTTLNIIKKNARLKEVMEEI-----
  80 .SVLrk...NKN....YRIVDVIKG...GVRFTSDKLEGYADEFASCRTRYEE---
  81 .GSV.....PRN....YELQSTKKG...FYRYWTPELKELILELSKAES-------
  82 .SKV.....PMN....WVKVNSTKK...TIRYHPPEIVAGLDEL------------
  83 .SKV.....PMN....WVKVNSTKK...TIRYHPPEIVAGLDEL------------
  84 .---.....---....---------...----------------------------
  85 .---.....---....---------...----------------------------
  86 .---.....---....---------...----------------------------
  87 .SKA.....NKS....YTLEGQTKGkkpSRRYTTAETRALLKDMQHAE--------
  88 sDQL.....PSE....FIKISKVKN...SYSFTSADLIKMNERCQES---------
  89 sDQL.....PSE....FIKISKVKN...SYSFTSADLIKMNERCQES---------
  90 .---.....---....---------...----------------------------
  91 .---.....---....---------...----------------------------
  92 .KSI.....RKKdv..HILETTKGS...GVKFSVGELSDINDEFLEFHLKYTRAE-
  93 .---.....---....---------...----------------------------
  94 .---.....---....---------...----------------------------
  95 .AQV.....PPH....FMESQALNS...SKRYKTEKLISLEVDINNAEDNVVAFE-
  96 .---.....---....---------...----------------------------
  97 .---.....---....---------...----------------------------
  98 .QQVrt...SKE....LITVSTSKD...GVRFVSERLSSLSEQYKGIRK-------
  99 .QSF.....KEN....WVVKSNFNN...NLRKLHEKLQSLFASYDKLQEDL-----
 100 .ESVti...PRY....FLDVFRNRT...TVTFNSRKVIAYNDRLEQVVAE------
 101 .DINsl...PEV....LINRVKKRK...TIECTTIELMKQSSRYNDIVSEIT----
 102 .---.....---....---------...----------------------------
 103 .QSF.....KEN....WVVKSNFNN...NLRKLHEKLQSLFASYDKLQEDL-----
 104 .---.....---....---------...----------------------------
 105 .---.....---....---------...----------------------------
 106 .ERM.....QNE....FP-------...----------------------------
 107 .ERM.....QNE....FP-------...----------------------------
 108 .---.....---....---------...----------------------------
 109 .EQA.....PGD....YIRRQTLKG...AERFITPELKAFEDKALSAKSRALARE-
 110 .PLLdgip.NLQ....WEEIFRSSE...NIYFKNGRVLELDE--------------
 111 .PLLdgip.NLQ....WEEIFRSSE...NIYFKNGRVLELDE--------------
 112 .---.....---....---------...----------------------------
 113 .---.....---....---------...----------------------------
 114 .---.....---....---------...----------------------------
 115 .---.....---....---------...----------------------------