; SAM: prettyalign v3.2 (July 31, 2000) compiled 08/11/00_16:27:51 ; (c) 1992-2000 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequences correspond to the following labels: ; 1 T0116-201-500 ; 2 gi|9654962|gb|AAF93703.1|_222:531 ; 3 gi|2497995|sp|Q56215|MUTS_THEAQ_203:500 ; 4 gi|4887554|emb|CAB43497.1|_217:524 ; 5 gi|127556|sp|P23909|MUTS_ECOLI_217:524 ; 6 gi|1592569|gb|AAB97931.1|_217:524 ; 7 gi|7448108|pir||S74860_287:595 ; 8 gi|7404405|sp|P73769|MUTS_SYNY3_253:561 ; 9 gi|7229490|gb|AAF42850.1|_214:523 ; 10 gi|7108493|gb|AAF36440.1|AF126491_1_214:523 ; 11 gi|127555|sp|P27345|MUTS_AZOVI_216:523 ; 12 gi|1171081|sp|P44834|MUTS_HAEIN_218:526 ; 13 gi|2145507|pir||S62790_211:507 ; 14 gi|2497996|sp|Q56239|MUTS_THETH_212:508 ; 15 gi|1871501|dbj|BAA09880.1|_212:508 ; 16 gi|2135744|pir||I37550_264:575 ; 17 gi|4557761|ref|NP_000242.1|_264:575 ; 18 gi|7448104|pir||I64827_264:575 ; 19 gi|7387928|sp|Q9ZIX6|MUTS_THECA_209:506 ; 20 gi|6678938|ref|NP_032654.1|_263:575 ; 21 gi|726086|gb|AAA75027.1|_263:575 ; 22 gi|1709122|sp|P54275|MSH2_RAT_264:575 ; 23 gi|417330|sp|P10339|MUTS_SALTY_219:525 ; 24 gi|6226653|sp|P74926|MUTS_THEMA_211:501 ; 25 gi|7387913|sp|O84797|MUTS_CHLTR_214:526 ; 26 gi|6754744|ref|NP_034960.1|_662:1021 ; 27 gi|1709123|sp|P52701|MSH6_HUMAN_665:1023 ; 28 gi|7512474|pir||JC5839_665:1023 ; 29 gi|1082386|pir||A56742_597:955 ; 30 gi|1619909|gb|AAB16999.1|_211:501 ; 31 gi|4504191|ref|NP_000170.1|_665:1023 ; 32 gi|7190210|gb|AAF39048.1|_214:526 ; 33 gi|7227419|gb|AAF42468.1|_217:518 ; 34 gi|7387924|sp|Q9Z6W5|MUTS_CHLPN_220:532 ; 35 gi|7189834|gb|AAF38705.1|_220:532 ; 36 gi|2506881|sp|P54276|MSH6_MOUSE_662:1021 ; 37 gi|7379009|emb|CAB83555.1|_217:518 ; 38 gi|7404403|sp|P49849|MUTS_BACSU_223:512 ; 39 gi|1002520|gb|AAB19235.1|_217:506 ; 40 gi|6320302|ref|NP_010382.1|_563:877 ; 41 gi|1588283|prf||2208298A_563:877 ; 42 gi|7512473|pir||JC5840_665:1023 ; 43 gi|123080|sp|P10564|HEXA_STRPN_211:510 ; 44 gi|6093453|sp|O83348|MUTS_TREPA_228:530 ; 45 gi|1079288|pir||S53609_262:573 ; 46 gi|79102|pir||A28668_219:524 ; 47 gi|1083296|pir||JC4019_478:788 ; 48 gi|387849|gb|AAB60711.1|_443:753 ; 49 gi|110917|pir||A32495_443:753 ; 50 gi|400971|sp|P13705|MSH3_MOUSE_443:753 ; 51 gi|3914079|sp|O66652|MUTS_AQUAE_222:518 ; 52 gi|9106782|gb|AAF84525.1|AE003995_7_258:565 ; 53 gi|4505249|ref|NP_002430.1|_476:789 ; 54 gi|1174416|sp|P43248|MSH2_DROME_246:566 ; 55 gi|7287834|gb|AAF44872.1|AE003406_77_250:570 ; 56 gi|118951|sp|P20585|MSH3_HUMAN_485:798 ; 57 gi|6647605|sp|Q9ZDM9|MUTS_RICPR_242:553 ; 58 gi|6226648|sp|O04716|MSH6_ARATH_641:977 ; 59 gi|7492209|pir||T41262_618:924 ; 60 gi|2104549|gb|AAB57798.1|_654:1015 ; 61 gi|3914053|sp|O13396|MSH2_NEUCR_249:561 ; 62 gi|1000883|gb|AAB59571.1|_262:529 ; 63 gi|3024198|sp|P70755|MUTS_AQUPY_222:518 ; 64 gi|172002|gb|AAA34802.1|_247:589 ; 65 gi|6324482|ref|NP_014551.1|_247:589 ; 66 gi|4139230|gb|AAD04176.1|_248:571 ; 67 gi|8473172|sp|P56883|MUTS_RHIME_251:566 ; 68 gi|3914056|sp|O24617|MSH2_ARATH_248:571 ; 69 gi|6319935|ref|NP_010016.1|_398:725 ; 70 gi|448278|prf||1916402A_397:724 ; 71 gi|4151103|emb|CAA07342.1|_266:586 ; 72 gi|1076927|pir||S22569_261:572 ; 73 gi|135075|sp|P26359|SWI4_SCHPO_353:664 ; 74 gi|7522263|pir||T39832_265:579 ; 75 gi|7331984|gb|AAF60672.1|_1110:1457 ; 76 gi|4775576|emb|CAB42554.1|_250:572 ; 77 gi|3319876|emb|CAA07684.1|_370:712 ; 78 gi|730066|sp|P40965|MSH4_YEAST_223:542 ; 79 gi|6321109|ref|NP_011187.1|_223:542 ; 80 gi|7298155|gb|AAF53392.1|_250:507 ; 81 gi|7012942|gb|AAF35250.1|AF227632_1_1:276 ; 82 gi|3914062|sp|O65607|MSH3_ARATH_353:725 ; 83 gi|7269404|emb|CAB81364.1|_353:725 ; 84 gi|3831701|gb|AAC70065.1|_236:505 ; 85 gi|8515837|gb|AAF76200.1|_236:505 ; 86 gi|1000879|gb|AAB59570.1|_262:482 ; 87 gi|7294307|gb|AAF49656.1|_515:858 ; 88 gi|4336728|gb|AAD17920.1|_262:584 ; 89 gi|4505251|ref|NP_002431.1|_262:584 ; 90 gi|3986757|gb|AAC84154.1|_164:450 ; 91 gi|7305281|ref|NP_038628.1|_164:450 ; 92 gi|3886083|gb|AAC78226.1|_259:546 ; 93 gi|3108220|gb|AAC62533.1|_165:451 ; 94 gi|4505253|ref|NP_002432.1|_165:451 ; 95 gi|3914075|sp|O51737|MUTS_BORBU_213:516 ; 96 gi|5725250|emb|CAB52406.1|_185:468 ; 97 gi|7328284|emb|CAB82466.1|_202:419 ; 98 gi|9864530|gb|AAG00261.1|_293:603 ; 99 gi|7522430|pir||T38256_135:417 ; 100 gi|5815430|gb|AAD52669.1|AF178755_1_159:495 ; 101 gi|7493777|pir||T18246_144:464 ; 102 gi|3914066|sp|Q19272|MSH5_CAEEL_236:606 ; 103 gi|6166561|sp|O13921|MSH1_SCHPO_296:578 ; 104 gi|1000877|gb|AAB59569.1|_262:423 ; 105 gi|9294039|dbj|BAB01996.1|_504:731 ; 106 gi|4775580|emb|CAB42556.1|_302:515 ; 107 gi|4775578|emb|CAB42555.1|_609:822 ; 108 gi|6224917|gb|AAF06013.1|AF193018_1_504:731 ; 109 gi|7243293|dbj|BAA92687.1|_39:229 ; 110 gi|1582703|prf||2119252A_235:528 ; 111 gi|6320047|ref|NP_010127.1|_235:528 ; 112 gi|6321912|ref|NP_011988.1|_327:582 ; 113 gi|172000|gb|AAA34801.1|_327:582 ; 114 gi|1000875|gb|AAB59568.1|_262:377 ; 115 gi|9558057|emb|CAC00183.1|_134:238 10 20 30 40 | | | | 1 MLSEAPFEPEGEGPLALRRARGALLAYAQRT......QGGA........LSLQP..FRFYDP... 2 FGTRDLVGFGVEQAKLGLCAAGCLIQYVKDT......QRTA........LPHIRs.LTWDRQ... 3 --SEAPFEPEGEGPLALRRARGALLAYAQRT......QGGA........LSLQP..FRFYDP... 4 FGTRDLVGFGVENAPRGLCAAGCLLQYAKDT......QRTT........LPHIRs.ITMERE... 5 FGTRDLVGFGVENAPRGLCAAGCLLQYAKDT......QRTT........LPHIRs.ITMERE... 6 FGTRDLVGFGVENAPRGLCAAGCLLQYAKDT......QRTT........LPHIRs.ITMERE... 7 ---KSLEGMGCEGLPLAIRAAGGLLEYIEDTq.....KAHV........VPIQP..LKTYGL... 8 ---KSLEGMGCEGLPLAIRAAGGLLEYIEDTq.....KAHV........VPIQP..LKTYGL... 9 FGTQDLKGFGCQNLTLAIGAAGCLLAYAKET......QRTA........LPHLRs.LRHDRL... 10 FGTQDLKGFGCQNLTLAIGAAGCLLAYAKET......QRTA........LPHLRs.LRHDRL... 11 --TQDLKGFGCDGLGLAIGAAGCLLAYARET......QRTA........LPHLRg.LRHERL... 12 -GTKDLRAFGVEKSPLGLSAAGCLLQYAKET......QRTA........LPHIQs.ISLIQN... 13 ---EAPFEPQGEGPLALRRAQGALLAYARAT......QGGA........LSVRP..FRLYDP... 14 ---EAPFEPQGEGPLALRRAQGALLAYARAT......QGGA........LSVRP..FRLYDP... 15 ---EAPFEPQGEGPLALRRAQGALLAYARAT......QGGA........LSVRP..FRLYDP... 16 --------------QVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LTTFDF... 17 --------------QVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LTTFDF... 18 --------------QVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LTTFDF... 19 ---EAPFDPEGEAPLALSRARGALLAYARAT......QGGA........LSVRP..FRLYDP... 20 -------------NQVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LATFDF... 21 -------------NQVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LATFDF... 22 --------------QVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LATFDF... 23 FGTRDLVGFGVENASRGLCAAGCLLQYVKDT......QRTS........LPHIRs.ITMERQ... 24 -----------ELSPLALKALAALIKYVKYTm.....IAED........LNLKP..PLLISQ... 25 FQVSSLDGFGLQGLVPAINAAGALLSYIQDK......LLLP........ISHLSi.PKIYGQ... 26 -ESDSVGLTPGEESELALSALGGIVFYLKKCli....DQEL........LSMAN..FEEYFPlds 27 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli....DQEL........LSMAN..FEEYIPlds 28 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli....DQEL........LSMAN..FEEYIPlds 29 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli....DQEL........LSMAN..FEEYIPlds 30 -----------ELSPLALKALAALIKYVKYTm.....IGED........LNLKP..PLLISQ... 31 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli....DQEL........LSMAN..FEEYIPlds 32 FQVSSLDGFGLQGLVPAINAAGALLSYIQDK......LLLP........ISHLSi.PKIYGQ... 33 ----RGFGLDGKEHAVAIGAAGALLNYIRLT......QNLM........PQHLDg.LSLETD... 34 FQVASLDGFGLKGLVPAINAAGGLLSYIQDK......LLLP........TKHIAi.PQTRGK... 35 FQVASLDGFGLKGLVPAINAAGGLLSYIQDK......LLLP........TKHIAi.PQTRGK... 36 -ESDSVGLTPGEESELALSALGGIVFYLKKCli....DQEL........LSMAN..FEEYFPlds 37 ----RGFGLDGKEHAVAIGAAGALLNYIRLT......QNLM........PQHLDg.LSLETD... 38 -----------------------LYTYLKRT......QKRS........LDHLQp.VQVYEL... 39 -----------------------LYTYLKRT......QKRS........LDHLQp.VQVYEL... 40 ---EVLKSYYDTGKKVGFSAFGGLLYYLKWLkl....DKNL........ISMKN..IKEYDFvks 41 ---EVLKSYYDTGKKVGFSAFGGLLYYLKWLkl....DKNL........ISMKN..IKEYDFvks 42 -ESDSIGLTPGEKSELALSALGGCVFYLKKCli....DQEL........LSMAN..FEEYIPlds 43 -----------RLATVEQTASSKLLQYVHRT......QMRE........LNHLKp.VIRYEI... 44 ----------LLPHSPDLAAAGALIAYLEET......TRHP........LSHVSa.ITRYHI... 45 -------------KQVAMSALAAVMKYLELLs.....DESN........FGQFV..MTNFDL... 46 FGTRDLVGFGVENASRGLCAAGCLLQYVKDT......QRTS........LPHIRs.ITMERQ... 47 --GSQSLSGVINLEKPVICALAAVIRYLKEFn.....LEKM........LSKPEs.FKQLSS... 48 --GSQSLSGVINLEKPVICALAAVIRYLKEFn.....LEKM........LSKPEs.FKQLSS... 49 --GSQSLSGVINLEKPVICALAAVIRYLKEFn.....LEKM........LSKPEs.FKQLSS... 50 --GSQSLSGVINLEKPVICALAAVIRYLKEFn.....LEKM........LSKPEs.FKQLSS... 51 --------------DTYSLPLGAVYKYAKTT......QKGY........TPLIPr.PKPYRD... 52 --LHDLSGFGIENNPQATAAAGALLGYIEET......QKQR........LPHLTs.ITMETV... 53 --GSQIISGIVNLEKPVICSLAAIIKYLKEFn.....LEKM........LSKPEn.FKQLSS... 54 ---EDATGLKELQLQLASNALKTAIKYLDLVn.....DAGN........LGHYE..IKQLDL... 55 ---EDATGLKELQLQLASNALKTAIKYLDLVn.....DAGN........LGHYE..IKQLDL... 56 --GSQIISGIVNLEKPVICSLAAIIKYLKEFn.....LEKM........LSKPEn.FKQLSS... 57 ----RDIKGIGEISNSQICAIGSILEYLSLT......QKQN........IPHLPi.PKIINF... 58 ----SELATEDKNGSLALSALGGAIYYLRQA......FLDEsll10fesLPYCD..FSNVNE... 59 ------LKSYLSEKPLAISAFGALFWYLRQLkl....DKDM........CSMGN..FDEYDAsqq 60 ----SELATEDKNGSLALSALGGAIYYLRQA......FLDEsll10fesLPYCD..FSNVNE... 61 ---------PQTDLKLAMGSASALIKYLGILh.....DPSN........FGQYQ..LYQHDL... 62 ------------ENQVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LTTFDF... 63 -----------EDL---SLSLGAVYRYAKAT......QKSF........TPLIPk.PKPYVD... 64 --DDLALSLPQKYSKLSMGACNALIGYLQLLs.....EQDQ........VGKYE..LVEHKL... 65 --DDLALSLPQKYSKLSMGACNALIGYLQLLs.....EQDQ........VGKYE..LVEHKL... 66 ----EPVRDLVSGFDLATPALGALLSFSELLs.....NEDN........YGNFT..IRRYDI... 67 ---VGTLDGFGSFSRAELAAASAAVSYVEKT......QLQE........RPALGi.PERESA... 68 ----EPVRDLVSGFDLATPALGALLSFSELLs.....NEDN........YGNFT..IRRYDI... 69 --AIKVMNEKIQLSPSLIRLVSKLYSHMVEY......NNEQ........VMLIPsiYSPFAS... 70 --AIKVMNEKIQLSPSLIRLVSKLYSHMVEY......NNEQ........VMLIPsiYSPFAS... 71 ----------ELGLQLAMASCNALLRYLGPA......LLNPdme9rentSRKLH..LYHHNL... 72 --IELHMEKVKSLHSLSIICLDMAISYLMEF......SLED........LFVASnfYQPFDS... 73 --IELHMEKVKSLHSLSIICLDMAISYLMEF......SLED........LFVASnfYQPFDS... 74 ---------PELGLQLAMASCNALLRYLGPA......LLNPdme9rentSRKLH..LYHHNL... 75 ---SSILPKPSTDWQLALSAFGAIFWYLRDSli....DVDM........LSMRN..VTIYNSnsm 76 ----EPVRDLLSQFDYALGPLGALLSYAELLa.....DDTN........YGNYT..IEKYNL... 77 -MSCLTVHTIMNMPHLTVQALALTFCHLKQF......GFER........ILYQGasFRSLSS... 78 -------------KTFALCAASAAISYMEEIiskssrNLNA........FRKLR..IQFEGT... 79 -------------KTFALCAASAAISYMEEIiskssrNLNA........FRKLR..IQFEGT... 80 ---EDATGLKELQLQLASNALKTAIKYLDLVn.....DAGN........LGHYE..IKQLDL... 81 -------------------------------......----........-----..------... 82 -MSCLTVHTIMNMPHLTVQALALTFCHLKQF......GFER........ILYQGasFRSLSS... 83 -MSCLTVQTIMNMPHLTVQALALTFCHLKQF......GFER........ILYQGasFRSLSS... 84 ---------------NMIRSFGALLLFLDET......RMGVtddplsvtSPIKS..IKTFTL... 85 ---------------NMIRSFGALLLFLDET......RMGVtddplsvtSPIKS..IKTFTL... 86 ------------ENQVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LTTFDF... 87 ---DHLGLTPNDNYKLALKALGQCIFFIHKCkl....EPKV........LPMAR..YQLYVPpdq 88 ---FSTVLMEVQSKYYCLAAVAALLKYVEFI......QNSV........YAPKSlkICFQGS... 89 ---FSTVLMEVQSKYYCLAAVAALLKYVEFI......QNSV........YAPKSlkICFQGS... 90 --ILFLSSIIPFDCVLTVRALGGLLKFLSRR......RIGVeledydvgVPILG..FKKFVL... 91 --ILFLSSIIPFDCVLTVRALGGLLKFLSRR......RIGVeledydvgVPILG..FKKFVL... 92 -------------------------------......----........--KYS..IFNYGT... 93 --ILFLSSIIPFDCLLTVRALGGLLKFLGRR......RIGVeledynvsVPILG..FKKFML... 94 --ILFLSSIIPFDCLLTVRALGGLLKFLGRR......RIGVeledynvsVPILG..FKKFML... 95 --ILGLSSLGFDEEKPYYISIFLIINHIKNN......LKNL........LSNIDk.IDINND... 96 -----RFTPIPLLIPSQVRALGGLLKFLGRR......RIGVeledynvsVPILG..FKKFML... 97 ----EIYSVNQTEHKLMYQATQLLLDYIHHT......QKRD........LSHIEd.VVQYAA... 98 -------RLALSNCPLASRAIEYLVSNIIDNf.....DATN........HRAFY..LKHTIP... 99 ---EIDPSFIKYCTKLEVTAGCTLISYIADRl.....QNSH........PNIQP..PIRVSL... 100 ---VSTVSEGCLRRTLALGALAVLLKYIHET......RCVF........FRVKSlrIKEMGV... 101 --NESTLGQVISNRKLSLAAANACIDYCVSTk.....MFRV........TNKIR..LKYCMC... 102 ---------------NMIRSFGALLLFLDET......RMGVtddplsvtSPIKS..IKTFTL... 103 ---EIDPSFIKYCTKLEVTAGCTLISYIADRl.....QNSH........PNIQP..PIRVSL... 104 ------------ENQVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LTTFDF... 105 --SWNCAVDGLNECDVALSALGELINHLSRLk.....LEDV........LKHGDi.FPYQVY... 106 ------------NQDVVICALGGLIGHLTRLm.....LHDA........LKNGEv.LPYHVY... 107 ------------NQDVVICALGGLIGHLTRLm.....LHDA........LKNGEv.LPYHVY... 108 --SWNCAVDGLNECDVALSALGELINHLSRLk.....LEDV........LKHGDi.FPYQVY... 109 -------------------------------......----........-----..------... 110 -------------------------------......----........--IHG..IRYIDI... 111 -------------------------------......----........--IHG..IRYIDI... 112 --------------QKELAALRNTLIYVSNH......LPDF........SINFQi.PQRQLA... 113 --------------QKELAALRNTLIYVSNH......LPDF........SINFQi.PQRQLA... 114 ------------ENQVAVSSLSAVIKFLELLs.....DDSN........FGQFE..LTTFDF... 115 -------------------------------......----........-----..------... 50 60 70 80 90 | | | | | 1 .....G.AFMRLPEATLRALEVFEPLRG.Q........DTLFSVLDETRT.APGRRLLQSWLRHP 2 .....D.QSVILDAATRRNLELTHNLAG.Gtd......NTLAEVLDHCAT.PMGSRMLKRWIHQP 3 .....G.AFMRLPEATLRALEVFEPLRG.Q........DTLFSVLDETRT.APGRRLLQSWLRHP 4 .....Q.DSIIMDAATRRNLEITQNLAG.Gae......NTLASVLDCTVT.PMGSRMLKRWLHMP 5 .....Q.DSIIMDAATRRNLEITQNLAG.Gae......NTLASVLDCTVT.PMGSRMLKRWLHMP 6 .....Q.DSIIMDAATRRNLEITQNLAG.Gae......NTLASVLDCTVT.PMGSRMLKRWLHMP 7 .....T.DFLVLDHQTRRNLEINQTVRD.Gsfh.....GSLLWALDRTST.TMGSRALRRWLLQP 8 .....T.DFLVLDHQTRRNLEINQTVRD.Gsfh.....GSLLWALDRTST.TMGSRALRRWLLQP 9 .....D.DTVILDGASRRNLELDINLSG.Gre......NTLQSVVDRCQT.AMASRLMSRWLNRP 10 .....D.DTVILDGASRRNLELDINLSG.Gre......NTLQSVVDRCQT.AMASRLMSRWLNRP 11 .....D.DTVILAGASRRNLELDVNLSG.Grd......NTLQSVIDRCQT.AMGSRLLGRWLNRP 12 .....Q.DCIQLDAATRRNLELTQNLAG.Gte......NTLASVLDKCVT.PMGSRLLKRWIHQP 13 .....G.AFVRLPEASLKALEVFEPLRG.Q........DTLFGVLDETRT.APGRRLLQAWLRHP 14 .....G.AFVRLPEASLKALEVFEPLRG.Q........DTLFGVLDETRT.APGRRLLQAWLRHP 15 .....G.AFVRLPEASLKALEVFEPLRG.Q........DTLFGVLDETRT.APGRRLLQAWLRHP 16 .....S.QYMKLDIAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQP 17 .....S.QYMKLDIAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQP 18 .....S.QYMKLDIAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQP 19 .....G.AIVRLPEASLKALEVFEPLRG.Q........DTLFGVLDETRT.APGRRLLQAWLRHP 20 .....S.QYMKLDMAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.AQGQRLVNQWIKQP 21 .....S.QYMKLDMAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.AQGQRLVNQWIKQP 22 .....S.QYMKLDMAAVRALNLFQGSVE.Dttgs....QSLAAFLNKCKT.AQGQRLVSQWIKQP 23 .....Q.DSIIMDAATRRNLEITQNLAG.Gve......NTLAAVLDCTVT.PMGSRMLKRWLHMP 24 .....R.DYMILDSATVENLSLIPGDRG.Kn.......--LFDVLNNTET.PMGARLLKKWILHP 25 .....Q.KHLLIDKASQTNLELLSPIHG.Ehgk.....GSLLQVMERTST.PMGGRLLRNTLINP 26 18tkaS.QRMVLDAVTLNNLEIFLNGTN.Gste.....GTLLERLDTCHT.PFGKRLLKQWLCAP 27 18tkaY.QRMVLDAVTLNNLEIFLNGTN.Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAP 28 18tkaY.QRMVLDAVTLNNLEIFLNGTN.Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAP 29 18tkaY.QRMVLDAVTLNNLEIFLNGTN.Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAP 30 .....R.DYMILDSATVENLSWIPGDRG.Kn.......--LFDVLNNTET.PMGARLGKKWILHP 31 18tkaY.QRMVLDAVTLNNLEIFLNGTN.Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAP 32 .....H.KHLLIDKASQTNLELLSAIHG.Ehgk.....GSLLQVMERTST.PMGGRLLRNTLVNP 33 .....S.QYIGMDAATRRNLEITQTLSG.Kks......PTLMSTLDLCAT.HMGSRLLALWLHHP 34 .....Q.QKLLIDTASQVNLELLAPLND.Pqgk.....NSLLRIMDHTST.PMGGRLLRQILISP 35 .....Q.QKLLIDTASQVNLELLAPLND.Pqgk.....NSLLRIMDHTST.PMGGRLLRQILISP 36 18tkaS.QRMVLDAVTLNNLEIFLNGTN.Gste.....GNLLERLDTCHT.PFGKRLLKQWLCAP 37 .....S.QYIGMDAATRRNLEITQTLSG.Kks......PTLMSTLDLCAT.HMGSRLLALWLHHP 38 .....E.EAMKIDLYSKRNLELTETIRS.Knkk.....GSLLWLLDETKT.AMGGRLLKQWIDRP 39 .....E.EAMKIDLYSKRNLELTETIRS.Knkk.....GSLLWLLDETKT.AMGGRLLKQWIDRP 40 .....Q.HSMVLDGITLQNLEIFSNSFD.Gsdk.....GTLFKLFNRAIT.PMGKRMMKKWLMHP 41 .....Q.HSMVLDGITLQNLEIFSNSFD.Gsdk.....GTLFKLFNRAIT.PMGKRMMKKWLMHP 42 18tkaY.QRMVLDAVTLNNLEIFLNGTN.Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAP 43 .....K.DFLQMDYATKASLDLVENARS.Gkkq.....GSLFWLLDETKT.AMGMRLLRSWIHRP 44 .....H.DFVEIDDATRKNLEILQNLHD.Stha.....HSLFETLNYTHT.AMGTRLLRYWLHHP 45 .....S.QYMKLDNAAVGALNLFPGSAE.Dtsgt....QSLAGLLNKCKT.PQGQRLVNQWIKQP 46 .....Q.DSIIMDAATRRNLEITQNLAG.Gve......NTLAAVLDCTVT.PMGSRMLKRWLHMP 47 .....GmEFMRINGTTLRNLEILQNQTD.Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQP 48 .....GmEFMRINGTTLRNLEILQNQTD.Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQP 49 .....GmEFMRINGTTLRNLEMVQNQTD.Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQP 50 .....GmEFMRINGTTLRNLEMVQNQTD.Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQP 51 .....E.GFVRLDIKAIKGLEILESLEG.Rkd......ISLFKVIDRTLT.GMGRRRLKFRLLSP 52 .....G.EAITMNAATRRHLELDTRVDG.Esr......HTLLGVLDSTVT.PMGGRLLRRWLHRP 53 .....KmEFMTINGTTLRNLEILQNQTD.Mktk.....GSLLWVLDHTKT.SFGRRKLKKWVTQP 54 .....N.RFVHLDSAAVAALNIMPKPGT.HpsmpsyrwQSVLGVLDHCRT.PQGHRLMGQWVKQP 55 .....N.RFVHLDSAAVAALNIMPKPGT.HpsmpsyrwQSVLGVLDHCRT.PQGHRLMGQWVKQP 56 .....KmEFMTINGTTLRNLEILQNQTD.Mktk.....GSLLWVLDHTKT.SFGRRKLKKWVTQP 57 .....H.NYMTIDFSTRRNLEIVTNLQG.Nly......GSVLNTLNHTVT.TQGGRLLYHFLSSP 58 .....K.QHMVLDAAALENLEIFENSRN.Ggys.....GTLYAQLNQCIT.ASGKRLLKTWLARP 59 .....S.TSLLMNGQTLKNLEIFSNSFD.Ggse.....GTLFHLLCRCVT.PFGKRLFHTWLCHP 60 .....K.QHMVLDAAALENLEIFENSRN.Ggys.....GTLYAQLNQCIT.ASGKRLLKTWLARP 61 .....A.QFMKLDAAALKALNLMPGARD.Gakn.....MSLYGLLNHCKT.PVGSRLLSQWLKQP 62 .....S.QYMKLDIAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQP 63 .....E.GYVKLDLKAVKGLEITESIEG.Rkd......LSLFKVVDRTLT.GMGRRRLRFRLLNP 64 .....K.EFMKLDASAIKALNLFPQGPQ.Npfg21gkvTSLFQLLNHCKT.NAGVRLLNEWLKQP 65 .....K.EFMKLDASAIKALNLFPQGPQ.Npfg21gkvTSLFQLLNHCKT.NAGVRLLNEWLKQP 66 .....G.GFMRLDSAAMRALNVMESKTD.Ankn.....FSLFGLMNRTCTaGMGKRLLHMWLKQP 67 .....A.STLFIDPATRANLELAKTLSG.Srd......GSLLKSLDRTMT.SGGARLLAERLMSP 68 .....G.GFMRLDSAAMRALNVMESKTD.Ankn.....FSLFGLMNRTCTaGMGKRLLHMWLKQP 69 .....K.IHMLLDPNSLQSLDIFTHDGG.K........GSLFWLLDHTRT.SFGLRMLREWILKP 70 .....K.IHMLLDPNSLQSLDIFTHDGG.K........GSLFWLLDHTRT.SFGLRMLREWILKP 71 .....E.QYMRLDIAAVRSLNLLPPPNG.Nahkt....MSLYGLLNHCRT.AMGARNLRRWIVQP 72 .....I.SSMVLSKQALEGLELFVNQTD.Htpv.....GSLFWVLDRTYT.RFGQRMLQRWLQKP 73 .....I.SSMVLSKQALEGLELFVNQTD.Htpv.....GSLFWVLDRTYT.RFGQRMLQRWLQKP 74 .....E.QYMRLDIAAVRSLNLLPPPNG.Nahkt....MSLYGLLNHCRT.AMGARNLRRWIVQP 75 15dwnG.KNLILDGTALENLNIVPNGRD.Shl......TSLYYVINKCST.PFGRRLLRSWLLQP 76 .....N.CYMRLDSAAVRALNIAEGKTDv-nkn.....FSLFGLMNRTCTvGMGKRLLNRWLKQP 77 .....N.TEMTLSANTLQQLEVVKNNSD.Gses.....GSLFHNMNHTLT.VYGSRLLRHWVTHP 78 .....E.NTMLIDSKTVRGLELVENKLD.Kng......ISLWKFLDTTST.KMGQRSLRNSILQP 79 .....E.NTMLIDSKTVRGLELVENKLD.Kng......ISLWKFLDTTST.KMGQRSLRNSILQP 80 .....N.RFVHLDSAAVAALNIMPKPGT.HpsmpsyrwQSVLGVLDHCRT.PQGHRLMGQWVKQP 81 .....-.-----DTAALENLELLENTRT.Ggls.....GTLYAQLNHCVT.GFGKRLLKRWIAKP 82 .....N.TEMTLSANTLQQLEVVKNNSD.Gses.....GSLFHNMNHTLT.VYGSRLLRHWVTHP 83 .....N.TEMTLSANTLQQLEVVKNNSD.Gses.....GSLFHNMNHTLT.VYGSRLLRHWVTHP 84 .....G.NLVEIDFNTIQALDILPKETE.Nkktfgqg.RSLYQLMDKCRS.TVGKKCLRKWFRNP 85 .....G.NLVEIDFNTIQALDILPKETE.Nkktfgqg.RSLYQLMDKCRS.TVGKKCLRKWFRNP 86 .....S.QYMKLDIAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQP 87 16tlrR.SHMVLDATTLSNLRII---GE.E........HSLLSTLDHCCT.KFGKRLLHHWLCAP 88 .....E.QTAMIDSSSAQNLELLINNQD.Yrnn.....HTLFGVLNYTKT.PGGSRRLRSNILEP 89 .....E.QTAMIDSSSAQNLELLINNQD.Yrnn.....HTLFGVLNYTKT.PGGSRRLRSNILEP 90 .....T.HLVSIDQDTYSVLQIFKSESH.Psvy12kegLSLFGILNRCRC.KWGQKLLRLWFTRP 91 .....T.HLVSIDQDTYSVLQIFKSESH.Psvy12kegLSLFGILNRCRC.KWGQKLLRLWFTRP 92 .....H.GNMLIDSCAVEALELFQLNYN.Yleksnn..LTLYNVLNKCKT.LPGEKLLRDWLSRP 93 .....T.HLVNIDQDTYSVLQIFKSESH.Psvy12kegLSLFGILNRCHC.KWGEKLLRLWFTRP 94 .....T.HLVNIDQDTYSVLQIFKSESH.Psvy12kegLSLFGILNRCHC.KWGEKLLRLWFTRP 95 .....S.SYMFLDDVTQVNLELVKNNND.Fssq.....YSLYSVLNDCKT.AMGKRLLREFILNP 96 .....T.HLVNIDQDTYSVLQIFKSESH.Psvy12kegLSLFGILNRCHC.KWGEKLLRLWFTRP 97 .....I.DYMKMDFYAKRNLELTESIRL.Kskk.....GTLLWLMDETKT.PMGARRLKQWIDRP 98 .....S.TFMKLDTAAIQALHIIHQKPE.Argslp...TSVYSWLNRCVT.GMGSRMMRQWLLQP 99 .....N.EYMIIGESAMKGLEIRSSLYQ.Nryt.....GSLLHAINKTVT.KSGSRLLTRRLCAP 100 .....N.DTCMIDFVSWESLEIVDADDA.Skar10kqkRTLMSVLNHTVT.TNGYRLLRSSVLQP 101 .....E.NTMLIDTCTVRDLELVDSLSE.Tg.......TTLYSFLNCCLT.KMGMRILRTSILQP 102 .....G.NLVEIDFNTIQALDILPKETE.Nkktfgqg.RSLYQLMDKCRS.TVGKKCLRKWFRNP 103 .....N.EYMIIGESAMKGLEIRSSLYQ.Nryt.....GSLLHAINKTVT.KSGSRLLTRRLCAP 104 .....S.QYMKLDIAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQP 105 .....R.GCLRIDGQTMVNLEIFNNSCD.Ggps.....GTLYKYLDNCVS.PTGKRLLRNWICHP 106 .....K.TCLRMDGQTLVNLEIFINNFN.Ggss.....GTLYKHLNHCVT.ASGKRMLRRWICHP 107 .....K.TCLRMDGQTLVNLEIFINNFN.Ggss.....GTLYKHLNHCVT.ASGKRMLRRWICHP 108 .....R.GCLRIDGQTMVNLEIFNNSCD.Gvlq.....GPLNKYLENCVS.PTGKRLLRNWICHP 109 .....-.---------------------.-........------------.-------------- 110 .....R.DRMVLDENTISALHIFPTAHK.Lghd10ngfFSVFELFNQVSS.DYARRILKSWLINP 111 .....R.DRMVLDENTISALHIFPTAHK.Lghd10ngfFSVFELFNQVSS.DYARRILKSWLINP 112 .....T.AIMQIDSRTSTALELHSTVRD.Nnkk.....GSLLSSIRRTVT.PSGTRLLSQWLSGP 113 .....T.AIMQIDSRTSTALELHSTVRD.Nnkk.....GSLLSSIRRTVT.PSGTRLLSQWLSGP 114 .....S.QYMKLDIAAVRALNLFQGSVE.Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQP 115 .....-.-CLHXPGPTLRALDVFHSSVG.Lr.......GSLVGLLDHSVT.PCGSRCLRRWLTAP 100 110 120 130 140 | | | | | 1 LLDRGPLEARLDRVEGFV.......R........EGALREGVR...RLLYRLADLERLATRLE.. 2 MRDNATLNQRLDAITELK.......-........ETALYGELH...PVLKQIGDIERILARLA.. 3 LLDRGPLEARLDRVEGFV.......R........EGALREGVR...RLLYRLADLERLATRLE.. 4 VRDTRVLLERQQTIGAL-.......-........-QDFTAELQ...PVLRQVGDLERILARLA.. 5 VRDTRVLLERQQTIGAL-.......-........-QDFTAGLQ...PVLRQVGDLERILARLA.. 6 VRHTRVLLERQQTIGAL-.......-........-QDFTAELQ...PVLRQVGDLERILARLA.. 7 LLDLKGIQARQDTIQELY.......H........HPALRQDLR...QLLRQIYDLERLTGRIG.. 8 LLDLKGIQARQDTIQELY.......H........HPALRQDLR...QLLRQIYDLERLTGRIG.. 9 LRDRAVLEARQESIACLL.......E........-RYRFENLQ...PQLKEIGDLERILARIG.. 10 LRDRAVLEARQESIACLL.......E........-RYRFENLQ...PQLKEIGDLERILARIG.. 11 LRDRAVLEARQDTVACLL.......Q........DY-RFESLQ...PQLKEIGDVERILARIG.. 12 VRDVEKLKQRQQSIAEIL.......-........NFDLVDELQ...PYLQLVGDMERILARVA.. 13 LLERGPLEARLDRVERFV.......R........EGALREGVR...RLLFRLADLERLATRLE.. 14 LLERGPLEARLDRVERFV.......R........EGALREGVR...RLLFRLADLERLATRLE.. 15 LLERGPLEARLDRVERFV.......R........EGALREGVR...RLLFRLADLERLATRLE.. 16 LMDKNRIEERLNLVEAFV.......E........DAELRQTLQe..DLLRRFPDLNRLAKKFQ.. 17 LMDKNRIEERLNLVEAFV.......E........DAELRQTLQe..DLLRRFPDLNRLAKKFQ.. 18 LMDKNRIEERLNLVEAFV.......E........DAELRQTLQe..DLLRRFPDLNRLAKKFQ.. 19 LLERGPLEARLDRVERFV.......R........EGALREGVR...RLLFRLADLERLATRLE.. 20 LMDRNRIEERLNLVEAFV.......E........DSELRQSLQe..DLLRRFPDLNRLAKKFQ.. 21 LMDRNRIEERLNLVEAFV.......E........DSELRQSLQe..DLLRRFPDLNRLAKKFQ.. 22 LMDKNRIEERLNLVEAFV.......E........DSELRRALQe..DLLRRFPDLNRLAKKFQ.. 23 VRNTDILRERQQTIGAL-.......-........-QDTVSELQ...PVLRQVGDLERTPC---.. 24 LVDRKQIEERLKAVERLV.......N........DRVSLEEMR...NLLSNVRDVERIVSRVE.. 25 FYDLKEITLRQDSVEFFL.......Q........QADLRKILK...RQLSCVRDLERLATKIS.. 26 LCSPSAISDRLDAVEDLM.......A........VPDKVTEVA...DLLKKLPDLERLLSKIHnv 27 LCNHYAINDRLDAIEDLM.......V........VPDKISEVV...ELLKKLPDLERLLSKIHnv 28 LCNHYAINDRLDAIEDLM.......V........VPDKISEVV...ELLKKLPDLERLLSKIHnv 29 LCNHYAINDRLDAIEDLM.......V........VPDKISEVV...ELLKKLPDLERLLSKIHnv 30 LVDRKQIEERLKAVERLV.......N........DRVSLEEMR...NLLSNVRDVERIVSRVE.. 31 LCNHYAINDRLDAIEDLM.......V........VPDKISEVV...ELLKKLPDLERLLSKIHnv 32 FYDLKEITLRQDSVEFFL.......K........QEPLRKTLK...RHLSCVRDLERLATKIS.. 33 LRNRAHIRARQEAVAAL-.......-........-ESQYKPLQ...CRLKSIADIERIAARIA.. 34 FYNPKEILVRQDAVEFFL.......R........QVTLRKNIK...TYLCQVRDIERLMTKVT.. 35 FYNPKEILVRQDAVEFFL.......R........QVTLRKNIK...TYLCQVRDIERLMTKVT.. 36 LCSPSAISDRLDAVEDLM.......A........VPYKVTEVA...DLLKKLPDLERLLSKIHnv 37 LRNRAHIRARQEAVAAL-.......-........-ESQYKPLQ...CRLKNIADIERIAARIA.. 38 LIRVNQIEERQEMVETLM.......S........HFFEREDLR...ERLKEVYDLERLAGRVA.. 39 LIRVNQIEERQEMVETLM.......S........HFFEREDLR...ERLKEVYDLERLAGRVA.. 40 LLRKNDIESRLDSVDSLL.......Q........DITLREQLE...ITFSKLPDLERMLARIH.. 41 LLRKNDIESRLDSVDSLL.......Q........DITLREQLE...ITFSKLPDLERMLARIH.. 42 LCNHYAINDRLDAIEDLM.......V........VPDKISEVV...ELLKKLPDLERLLSKIHnv 43 LIDKERIVQRQEVVQVFL.......D........HFFERSDLT...DSLKGVYDIERLASRVS.. 44 LRSQEEIQKRLSAVVFFH.......H........RPHILKTLR...ATLSCVRDVERLVARVA.. 45 LMDKNRVEERLNLVEAFV.......M........DVELRQCLQe..DLLRRFPDLNRLAKKFQ.. 46 VRNTDILRERQQTIGAL-.......-........-QDTVSELQ...PVLRQVGDLERTPC---.. 47 LLKLREINARLDAVSDVLh......S........ESSVFEQIE...NLLRKLPDVERGLCSIY.. 48 LLKLREINARLDAVSDVLh......S........ESSVFEQIE...NLLRKLPDVERGLCSIY.. 49 LLKLREINARLDAVSDVLh......S........ESSVFEQIE...NLLRKLPDVERGLCSIY.. 50 LLKLREINARLDAVSDVLh......S........ESSVFEQIE...NLLRKLPDVERGLCSIY.. 51 FRSREKIERIQEGVQELK.......E........NREALLKIR...QILEGMADLERLVSKIS.. 52 LRLREVVRQRHAAVGSMI.......-........DRDLDNKLM...ETFRRLGDMERILTRVA.. 53 LLKLREINARLDAVSEVLh......S........ESSVFGQIE...NHLRKLPDIERGLCSIY.. 54 LRSRNILNDRHNIVQCLL.......E........SPDTMETLSl..DYLKRIPDILMLTKKLM.. 55 LRSRNILNDRHNIVQCLL.......E........SPDTMETLSl..DYLKRIPDILMLTKKLM.. 56 LLKLREINARLDAVSEVLh......S........ESSVFGQIE...NHLRKLPDIGRGLCSIY.. 57 LTNIAKINHRLNITEFFY.......S........NLGIVTRIR...ELLKNTSDIERCLTRIT.. 58 LYNTELIKERQDAVAILRg......E........NLPYSLEFR...KSLSRLPDMERLIARMFss 59 LRSGTAINARLDVVELIA.......D........NPVIRDTIW...GFLHKLPDLERLISRVH.. 60 LYNTELIKERQDAVAILRg......E........NLPYSLEFR...KSLSRLPDMERLIARMFss 61 LMNAEEIEKRQQLVEAFA.......N........DTELRQSMQe..EHLRSIPDLYRLSKRFQ.. 62 LMDKNRIEERLNLVEAFV.......E........DAELRQTLQe..DLLRRFPDLNRLAKKFQ.. 63 FRSIERIRKVQEAVEELI.......N........KREVLNEIR...KTLEGMSDLERLVSRIS.. 64 LTNIDEINKRHDLVDYLI.......D........QIELRQMLTs..EYLPMIPDIRRLTKKL-.. 65 LTNIDEINKRHDLVDYLI.......D........QIELRQMLTs..EYLPMIPDIRRLTKKL-.. 66 LVDLNEIKTRLDIVQCFV.......E........EAGLRQDLR...QHLKRISDVERLLRSLE.. 67 LTDPERINQRLDSIEVLA.......D........QPRFTTDVR...DALRRAPDMPRALSRLA.. 68 LVDLNEIKTRLDIVQCFV.......E........EAGLRQDLR...QHLKRISDVERLLRSLE.. 69 LVDVHQIEERLDAIECITsei....N........NSIFFESLN...QMLNHTPDLLRTLNRIM.. 70 LVDVHQIEERLDAIECITsei....N........NSIFFESLN...QMLNHTPDLLRTLNRIM.. 71 LLDAKSIERRHDLVSALV.......E........DAEARQLLLdddHLLRSIPDIPKLCRRLT.. 72 LVDKENIIERLDAVEELAf......N........SNSQVQAIR...KMLYRLPDLEKGLSRIYyq 73 LVDKENIIERLDAVEELAf......N........SNSQVQAIR...KMLYRLPDLEKGLSRIYyq 74 LLDAKSIERRHDLVSALV.......E........DAEARQLLLdddHLLRSIPDIPKLCRRLT.. 75 TCDPKKLEQRQKAIKWLVsp.....D........ASSFMTTAT...ATLKKIPDLDRLLQKIHti 76 LLDVNEINNRLDMVQAFV.......E........DPELRQGLR...QQLKRISDIDRLTHSLR.. 77 LCDRNLISARLDAVSEIS.......Acmg27speFYLVLSSVL...TAMSRSSDIQRGITRIF.. 78 LTDRGSIEMRLEALEELK.......A........NDDLLQKLR...LEMKSLPDLDKLFSRLLci 79 LTDRGSIEMRLEALEELK.......A........NDDLLQKLR...LEMKSLPDLDKLFSRLLci 80 LRSRNILNDRHNIVQCLL.......E........SPDTMETLSl..DYLKR------------.. 81 LYDCREILRRQSAVATFKg......V........GQDCAAQFR...KDLSRLPDMERLLARLFss 82 LCDRNLISARLDAVSEIS.......Acmg27speFYLVLSSVL...TAMSRSSDIQRGITRIF.. 83 LCDRNLISARLDAVSEIS.......Acmg27speFYLVLSSVL...TAMSRSSDIQRGITRIF.. 84 TTDRDDLVSRQKCVHYFKqd.....W........NAEVTAKLS...SILGRVKALNSVFQKFQ.. 85 TTDRDDLVSRQKCVHYFKqd.....W........NAEVTAKLS...SILGRVKALNSVFQKFQ.. 86 LMDKNRIEERLNLVEAFV.......E........DAELRQTLQe..DLLRRFPDLNRLAKKFQ.. 87 SCDVSVIKERQDAIGELI.......R........MPTELQEVR...ALLAPMPDFERNLAQIHlf 88 LVDIETINMRLDCVQELL.......Q........DEELFFGLQ...SVISRFLDTEQLLSVLVqi 89 LVDIETINMRLDCVQELL.......Q........DEELFFGLQ...SVISRFLDTEQLLSVLVqi 90 TRELRELNSRLDVIQFFLmp.....Q........NLDMAQMLH...RLLSHIKNVPLILKRMK.. 91 TRELRELNSRLDVIQFFLmp.....Q........NLDMAQMLH...RLLSHIKNVPLILKRMK.. 92 LCQIDHINERLDIVEALF.......E........NQTIRQKLRd..SILARMPDCSQLARRL-.. 93 THDLGELSSRLDVIQFFLlp.....Q........NLDMAQMLH...RLLGHIKNVPLILKRMK.. 94 THDLGELSSRLDVIQFFLlp.....Q........NLDMAQMLH...RLLGHIKNVPLILKRMK.. 95 ILNISEINTRLDHVEFFC.......K........NISLTVTLR...ETFINIWDIERIISRIQ.. 96 THDLGELSSRLDVIQFFLlp.....Q........NLDMAQMLH...RLLGHIKNVPLILKRMK.. 97 LISKEQIEARLDIVDEFS.......A........HFIERDTLR...TYLNQVYDIERLVGRVS.. 98 LRNAEDINQRLSLVELMV.......E........DSILRDALLs..QVLRCCGDMDRLNRKLQ.. 99 STNIVEINNRLDLVEKFK.......L........LPELCSKVI...NLLKKSNDTHRILQHLL.. 100 STDVYLIQSRQEAIEELI.......G........KPQLKDKLR...RTLSRAHELDRVIAMCIqt 101 STHENSIILRSESLQELI.......N........DEDALISIR...SSLKHTCDLEKVFSTFLep 102 TTDRDDLVSRQKCVHYFKqviifkvE........YRNLWEIFL...NHSKFSPDSEYLSEKIFlk 103 STNIVEINNRLDLVEKFK.......L........LPELCSKVI...NLLKKSNDTHRILQHLL.. 104 LMDKNRIEERLNLVEAFV.......E........DAELRQTLQe..DLLRRFPDLNRLAKKFQ.. 105 LKDVESINKRLDVVEEFT.......A........NSESMQITG...QYLHKLPDLERLLGRIKss 106 LKDIDAINKRLDVVEGFI.......Q........NCGLGPTTL...GYLQKIPDLERLLGQV-.. 107 LKDIDAINKRLDVVEGFI.......Q........NCGLGPTTL...GYLQKIPDLERLLGQV-.. 108 LKDVESINKRLDVVEEFT.......A........NSESMQITG...QYLHKLPDLERLLGRIKss 109 ------------------.......-........---IGVDVS...PVMIKVVDAAVQKARIG.. 110 LTNKKRIETRYSIIRTLLdk.....Q........NAIIFSDLS...QSIKRCPDAFGFINQLR.. 111 LTNKKRIETRYSIIRTLLdk.....Q........NAIIFSDLS...QSIKRCPDAFGFINQLR.. 112 SLDLKEIKKRQKIVAFFK.......D........NRDITETLR...TMLKKVNDLSRILQKFS.. 113 SLDLKEIKKRQKIVAFFK.......D........NRDITENLR...TMLKKVNDLSRILQKFS.. 114 LMDKNRIEERLNLVEAFV.......E........DAELRQTLQ...-----------------.. 115 LCERASIVARQEVLAYLMvc.....K........DDXQVEDXL...HECARXGDXEAVVSKLX.. 150 160 170 180 190 | | | | | 1 ......LGRASPKDLGALRR.SLQILPELRALLGEEVG........LPDLSPLKEELEAALVEDP 2 ......LRSARPRDLARLRH.AMQQLPELHSVMSELKQphl9lrthAEPMDELCDLLERAIKENP 3 ......LGRASPKDLGALRR.SLQILPELRALLGEEVG........LPDLSPLKEELEAALVEDP 4 ......LRTARPRDLARMRH.AFQQLPELRAQLETVDSapv9lrekMGEFAELRDLLERAIIDTP 5 ......LRTARPRDLARMRH.AFQQLPELRAQLETVDSapv9lrekMGEFAELRDLLERAIIDTP 6 ......LRTARPRDLARMRH.AFQQLPELRAQLETVDSapv9lrekMGEFAELRDLLERAIIDTP 7 ......ANTASARDVYGLAS.SLVRLTDLAELAQEGHSpyl9lqtvPPELEELGKYVLAHIVENP 8 ......ANTASARDVYGLAS.SLVRLTDLAELAQEGHSpyl9lqtvPPELEELGKYVLAHIVENP 9 ......LRNARPRDLARLRD.ALAALPDLQNAMTELEAphl9lattIGTYPELAELLAKAIIDNP 10 ......LRNARPRDLARLRD.ALAALPDLQNAMTELEAphl9lattIGTYPELAELLAKAIIDNP 11 ......LRNARPRDLARLRD.ALAALPQLQTALSPLEAphl9lagnIRTYPELAELLRRAIIDNP 12 ......LRSARPRDLTRLRT.ALEQIPALRAIVQQKTPpfl9lfsqIADFSEQCDLLQRALIETP 13 ......LSRASPRDLAALRR.SLEILPELKGLLGEEVG........LPDLSGLLEELRAALVEDP 14 ......LSRASPRDLAALRR.SLEILPELKGLLGEEVG........LPDLSGLLEELRAALVEDP 15 ......LSRASPRDLAALRR.SLEILPELKGLLGEEVG........LPDLSGLLEELRAALVEDP 16 ......RQAANLQDCYRLYQ.GINQLPNVIQALEKHEGkhq17tdlRSDFSKFQEMIETTLDMD- 17 ......RQAANLQDCYRLYQ.GINQLPNVIQALEKHEGkhq17tdlRSDFSKFQEMIETTLDMD- 18 ......RQAANLQDCYRLYQ.GINQLPNVIQALEKHEGkhq17tdlRSDFSKFQEMIETTLDMD- 19 ......LSRASPRDLAALRRrSLEILPELEGLLGEEVG........LPDLSGLLEELRAALVEDP 20 ......RQAANLQDCYRLYQ.GINQLPSVIQALEKYEGrhq17idlRSDFSKFQEMIETTLDMD- 21 ......RQAANLQDCYRLYQ.GINQLPSVIQALEKYEGrhq17idlRSDFSKFQEMIETTLDMD- 22 ......RQAANLQDCYRLYQ.GVKQLPNVIQALEKYQGrhq17tdlRSDFSKFQEKIETTLDMD- 23 ......-ASGAAQPSARSRP.NASRLPAAAELHAQLETvds12rkkMGDFAELRDLLERAIIDAP 24 ......YNRSVPRDLVALRE.TLEIIPKLNEVLSTFGVfkk.....LAFPEGLVDLLRKAIEDDP 25 ......TSLATPKDIGTLRD.SLLSCTHIADNLQNCALpef10fliAPPLCSLIKTLSTELIQEL 26 g23ettYSKKKIIDFLSALE.GFKVMCKVSGLLEEVAGgft21kgrFPDLTAELQRWDTAFDHEK 27 g23ettYSKKKIIDFLSALE.GFKVMCKIIGIMEEVADgfk21egrFPDLTVELNRWDTAFDHEK 28 g23ettYSKKKIIDFLSALE.GFKVMCKIIGIMEEVADgfk21egrFPDLTVELNRWDTAFDHEK 29 g23ettYSKKKIIDFLSALE.GFKVMCKIIGIMEEVADgfk21egrFPDLTVELNRWDTAFDHEK 30 ......YNRSVPRDLVALRE.TLEIIPKLNEVLSTFGVfkk.....LAFPEGLVDLLRKAIEDDP 31 g23ettYSKKKIIDFLSALE.GFKVMCKIIGIMEEVADgfk21egrFPDLTVELNRWDTAFDHEK 32 ......TTLASPKDIGMLRD.SLLSCMHIAHDLQSYTLpef10cliSSSLKSLIEALSTDLLQEL 33 ......VGNARPRDLAALRD.SLFALSEIELSAECSSLlgtlkav.FPENLSTAEQLRQAILPEP 34 ......TGLAGPRDIGTLRD.SFSAGAQIYEQLASATLpef10cslDTKLASLIALLSKSLNGDL 35 ......TGLAGPRDIGTLRD.SFSAGAQIYEQLASATLpef10cslDTKLASLIALLSKSLNGDL 36 g23ettYSKKKIIDFLSALE.GFKVMCKVSGLLEEVAGgft21kgrFPDLTAELQRWDTAFDHEK 37 ......VGNARPRDLASLRD.SLFELAQIDLSANGSSLletlkav.FPENLSTAEQLRQAILPEP 38 ......FGNVNARDLIQLKE.SLKQVPGIKQLVASLAHdka9rakrIDPCGDVLELLEEALYENP 39 ......FGNVNARDLIQLKE.SLKQVPGIKQLVASLAHdka9rakrIDPCGDVLELLEEALYENP 40 ......SRTIKVKDFEKVIT.AFETIIELQDSLKNNDL........KGDVSKYISSFPEGLVEAV 41 ......SRTIKVKDFEKVIT.AFETIIELQDSLKNNDL........KGDVSKYISSFPEGLVEAV 42 g23ettYSKKKIIDFLSALE.GFKVMCKIIGIMEEVADgfk21egrFPDLTVELNRWDTAFDHEK 43 ......FGKTNPKDLLQLAT.TLSSVPRIRAILEGMEQptl9liaqLDAIPELESLISAAIAPEA 44 ......LEKAHGRDLLALKE.SLRAILTFRSLERESPFppd10egdTPVLQELYGLLEQSIKEDC 45 ......RQTANLQDCYRLYQ.AVNHLPTVVQAIEKYEGthq17sdlSSDFSKFQEMIETTLDMD- 46 ......-ASGAAQPSARSRP.NASRLPAAAELHAQLET........VDSAPVQRCVKKWAISPSC 47 ......HKKCSTQEFFLIVK.SLCQLKSELQALMPAVNshv11ralIVELLSPVEHYLKVLNGPA 48 ......HKKCSTQEFFLIVK.SLCQLKSELQALMPAVNshv11ralIVELLSPVEHYLKVLNGPA 49 ......HKKCSTQEFFLIVK.SLCQLKSELQALMPAVNshv11ralIVELLSPVEHYLKVLNGPA 50 ......HKKCSTQEFFLIVK.SLCQLKSELQALMPAVNshv11ralIVELLSPVEHYLKVLNGPA 51 ......SNMATPRELVYLKN.SLKKVEELRLLLLELKApif9ilqnFEDTKKIINDIEKTLVEDP 52 ......LRSARPRDISTLRD.SLSLLPRLRELLNASDSprl9lyaeLGEHDSTASLLVKAVAEQP 53 ......HKKCSTQEFFLIVK.TLYHLKSEFQAIIPAVNshi14ileIPELLSPVEHYLKILNEQA 54 ......RRKANLQDLFRIYQ.VILRTPKILKVLHELDNsti14ksfLKDLTGLKQMVEQVVDFE- 55 ......RRKANLQDLFRIYQ.VILRTPKILKVLHELDNsti14ksfLKDLTGLKQMVEQVVDFE- 56 ......HKKCSTQEFFLIVK.TLYHLKSEFQAIIPAVNshi14ileIPELLSPVEHYLKILNEQA 57 ......MNRSSGRDLLSIKY.TLETAKTIKGLFSESYGlnl13ikpLSGDAELYNLIHMSIREDA 58 i18yedTAKKQVQEFISTLR.GCETMAEACSSLRAILKhdt16gqsLPNISSSIKYFKDAFDWVE 59 ......AGRSKPADFVRVLE.GFQRINSAFDQLREEFMeva14iqsAPNMKEELEAWTRAFNWQK 60 i18yedTAKKQVQEFISTLR.GCETMAEACSSLRAILKhdt41gqsLPNISSSIKYFKDAFDWVE 61 ......RGKATLEDVVRAYQ.VVIRLPGFIGTLEGVMDeay18relSDSLVKLQEMVETTVDLD- 62 ......RQAANLQDCYRLYQ.GINQLPNVIQALEKHEGkhq17tdlRSDFSKFQEMIETTLDMD- 63 ......SNMASPRELIHLKN.SLRKAEELRKILSLLDSeif9iegsLLNLNKVADLIDKTLVDDP 64 ......NKRGNLEDVLKIYQ.FSKRIPEIVQVFTSFLEdds23shhVEPLSKFEEMVETTVDLDA 65 ......NKRGNLEDVLKIYQ.FSKRIPEIVQVFTSFLEdds23shhVEPLSKFEEMVETTVDLDA 66 ......RRRGGLQHIIKLYQ.SAIRLPFIKTAMQQYTGefa19lsdQDHLGKFIDLVECSVDLD- 67 ......LGRGGPRDLGAIQA.GMRAAAAISALLSGAELsae11daiAALPGELLARLDATLAEEL 68 ......RRRGGLQHIIKLYQ.STIRLPFIKTAMQQYTGefa19lsdQDHLGKFIDLVECSVDLD- 69 ......YGTTSRKEVYFYLK.QITSFVDHFKMHQSYLSehf29llsTTQLPHFLTMINVSAVMEK 70 ......YGTTSRKEVYFYLK.QITSFVDHFKMHQSYLSehf29llsTTQLPHFLTMINVSAVMEK 71 ......RGSASLEDVVRIYQ.MAKALPKIVTVLDSLTSehk17nnhCKNLEKLIELVETTIDLE- 72 r13afsKNSYSCFKSALLRR.LIQQLPSISSIIDHFLGmf......DQKEAENNNKVDMFKDIDN 73 r13afsKNSYSCFKSALLRR.LIQQLPSISSIIDHFLGmf......DQKEAENNNKVDMFKDIDN 74 ......RGSASLEDVVRIYQ.MAKALPKIVTVLDSLTSehk17nnhCKNLEKLIELVETTIDLE- 75 g23tikTNQKKIAELLAAID.GFKLCNKLRKEYIKVQKege17eqeMEEVDENIYFFEKMFDRST 76 ......KKSANLQPVVKLYQ.SCSRIPYIKGILQQYNGqfs19wmaKNRFGRFSSLVETAIDLA- 77 ......HRTAKATEFIAVME.AILLAGKQIQRLGIKQDsem28pvvVDNAGKLLSALNKEAAVRG 78 nhsai.KPDQRINYVLLLKE.TLQSVKSLKDALNDQLIqsr13ifnNDAIMEIEKLINSCINEDC 79 nhsai.KPDQRINYVLLLKE.TLQSVKSLKDALNDQLIqsr13ifnNDAIMEIEKLINSCINEDC 80 ......--------------.-----------------........------LKQMVEQVVDFE- 81 c17yedASKKLLQQFTSALC.GCQQMFHACSSISTLICseg15gkgLSNISSILDRFRDAFDWSD 82 ......HRTAKATEVKIWPV.LCPLMYVPVSSSPGLRVlnf58pvvVDNAGKLLSALNKEAAVRG 83 ......HRTAKATEV-KIWP.VLCPLMYVPGSSSPGLRvln59pvvVDNAGKLLSALNKEAAVRG 84 ......SGTAQLIHWECFVS.TVNALVEILNIIRQTPIske10sdlLREVSEIAVIAGSIINFAE 85 ......SGTAQLIHWECFVS.TVNALVEILNIIRQTPIske10sdlLREVSEIAVIAGSIINFAE 86 ......RQAANLQDCYRLYQ.GINQLPNVIQALEKHEGkhq17tdlRSDFSKFQEMIETTLDMD- 87 g24eklYNKQKLQGFMAVLK.GFNDLTKLPTMFHQCKTtll15ggsFPDLSKELQYFATAFDHDA 88 p9dtvnAAESKITNLIYLKH.TLELVDPLKIAMKNCNTpll11sleDKRFGIILEKIKTVINDDA 89 p9dtvnAAESKITNLIYLKH.TLELVDPLKIAMKNCNTpll11sleDKRFGIILEKIKTVINDDA 90 ......LSHTKVSDWQVLYK.TVYSALGLRDACRSLPQsiq12qefSDDLHHIASLIGKVVDFEE 91 ......LSHTKVSDWQVLYK.TVYSALGLRDACRSLPQsiq12qefSDDLHHIASLIGKVVDFEE 92 ......MRKCTLQDLNRFYQ.AATLLETVEMQLIQLSEaeq19teiLKKVERFQVLCDEFFDFDY 93 ......LSHTKVSDWQVLYK.TVYSALGLRDACRSLPQsiq12qefSDDLHHIASLIGKVVDFEG 94 ......LSHTKVSDWQVLYK.TVYSALGLRDACRSLPQsiq12qefSDDLHHIASLIGKVVDFEG 95 ......MKRYIKKDFLFIEK.ALSVFFTVKKLFDKHNFdyw9dkfeEDSISKVYFLINSAISSAP 96 ......LSHTKVSDWQVLYK.TVYSALGLRDACRSLPQsiq12qefSDDLHHIASLIGKVVDFEG 97 ......YGNVNARDLIQLKH.SISEIPNIKALLNSMNQntlvqvnqLEPLDDLLDILEQSLVEEP 98 ......RRSIALKDLQSILT.FVNTIPRAVQVLRTHQGgrn14iapLEDINEHFSNLRILITATV 99 ......MGRGNSYDLLKMAD.NFSITKEIHSLLSPLESssa10llnMHPHDELKQLINNAVDENA 100 s9wtvrESEAKINQIIKLMH.TLKVIQGIRTLLHSAKMksn13flkDPRFDQIMNILVEKVDDSL 101 rgll..SQEQEINNIILLKT.VLQNTFVIRKSIQNVSShll11ileHENVQHLLAIINEYIRNDC 102 k96kfqSGTAQLIHWECFVS.TVNALVEILNIIRQTPIske10sdlLREVSEIAVIAGSIINFAE 103 ......MGRGNSYDLLKMAD.NFSITKEIHSLLSPLESssa10llnMHPHDELKQLINNAVDENA 104 ......RQAANLQDCYRLYQ.GINQLPNVIQALEK---........------------------- 105 v17gkkVLKQRVKAFGQIVK.GFRSGIDLLLALQKESNmms16lvgKSGLELFLSQFEAAIDSDF 106 ......--------------.------------RSTVG........LSSLLQLPFIGEKIIK--- 107 ......--------------.------------RSTVG........LSSLLQLPFIGEKIIK--- 108 v17gkkVLKQRVKAFGQIVK.GFRSGIDLLLALQKESNmms16lvgKSGLELFLSQFEAAIDSDF 109 ......LRNARPRDLARLRD.ALGALPELQNAMTELEAphl9laaiTGTYPELASLLERAIIDNP 110 ......SGKSTLGTWSKVAS.FLEKGIAIFQLVSSLKLgsd16kvdISALKECLRKVETVIDFDT 111 ......SGKSTLGTWSKVAS.FLEKGIAIFQLVSSLKLgsd16kvdISALKECLRKVETVIDFDT 112 ......FGRGEALELIQMAR.SLEVSREIRKYLLNNTSlmk23knlIDDILKFLNEEELAKSQDA 113 ......FGRGEALELIQMAR.SLEVSREIRKYLLNNTSlmk23knlIDDILKFLNEEELAKSQDA 114 ......--------------.-----------------........------------------- 115 ......AERCQVVEFX----.-----------------........------------------- 200 210 220 230 | | | | 1 P........LKVSEGGLIREGYDPDLDALR.AAHREGVAYFLELEERERERT...G..IP..... 2 P........VVIRDGGVIADGYSAELDEWR.DLANGATEFLERLEAEERDRH...G..ID..... 3 P........LKVSEGGLIREGYDPDLDALR.AAHREGVAYFLELEERERERT...G..IP..... 4 P........VLVRDGGVIASGYNEELDEWR.ALADGATDYLERLEVRERERT...G..LD..... 5 P........VLVRDGGVIASGYNEELDEWR.ALADGATDYLERLEVRERERT...G..LD..... 6 P........VLVRDGGVIASGYNEELDEWR.ALADGATDYLERLEVRERERT...G..LD..... 7 P........LHIREGNLIRSGVNPTLDEMR.QSLEDDNQWLANLEVTEREKT...G..IA..... 8 P........LHIREGNLIRSGVNPTLDEMR.QSLEDDNQWLANLEVTEREKT...G..IA..... 9 P........AVIRDGGVIKTGYDAELDELQ.ALSENAGQFLMDLEAREKART...G..LP..... 10 P........AVIRDGGVIKTGYDAELDELQ.ALSENAGQFLMDLEAREKART...G..LP..... 11 P........AVIRDGGVLKQGYDAELDELL.SLSENAGQFLMDLEAREKART...G..LP..... 12 P........LLIRDGGVIAEGYNAELDEWR.MLSDGATQYLENLEKREREST...G..ID..... 13 P........LKVSEGGLIREGYDPDLDALR.RAHAEGVAYFLDLEAREKERT...G..IP..... 14 P........LKVSEGGLIREGYDPDLDALR.RAHAEGVAYFLDLEAREKERT...G..IP..... 15 P........LKVSEGGLIREGYDPDLDALR.RAHAEGVAYFLDLEAREKERT...G..IP..... 16 -........QVENHEFLVKPSFDPNLSELR.EIMNDLEKKMQSTLISAARDL...G..LDpgk.. 17 -........QVENHEFLVKPSFDPNLSELR.EIMNDLEKKMQSTLISAARDL...G..LDpgk.. 18 -........QVENHEFLVKPSFDPNLSELR.EIMNDLEKKMQSTLISAARDL...G..LDpgk.. 19 P........LKVSEGGVIREGYDPDLDALR.RAHADPVAYFLDLEVREKEST...G..IP..... 20 -........QVENHEFLVKPSFDPNLSELR.EVMDGLEKKMQSTLINAARGL...G..LDpgk.. 21 -........QVENHEFLVKPSFDPNLSELR.EVMDGLEKKMQSTLINAARGL...G..LDpgk.. 22 -........QVENHEFLVKPSFDPNLSELR.EVMDGLEKKMQSTLISAARGL...G..LDpgk.. 23 P........VLVRDGAVIAPGYHEELDEWR.ALADGATDYLDRLEIRERERT...G..LD..... 24 V........GSPGEGKVIKRGFSSELDEYR.DLLEHAEERLKEFEEKERERT...G..IQ..... 25 P........LKVSEGNIFANHYHPDLLRLR.NIKENSKSWILEYQERIRNET...G..IK..... 26 -........ARKTGLITPKAGFDSDYDQAL.ADIRENEQSLLEYLDKQRSRL...G..CK..... 27 -........ARKTGLITPKAGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR..... 28 -........ARKTGLITPKAGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR..... 29 -........ARKTGLITPKAGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR..... 30 V........GSPGEGKVIKRGFSSELDEYR.DLLEHAEERLKEFEEKERERT...G..IQ..... 31 -........ARKTGLITPKAGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR..... 32 P........LKVSEGNIFADHYHQDLLRLR.NIKTNSKSWILEYQERIRQET...G..IK..... 33 S........VWLKDGNVINHGFHPELDELR.RIQNHGDEFLLDLEAKERERT...G..LS..... 34 P........LRVSDGNIFVDEFHNDLKRLR.HNQEHSQEWIWEYQERIRKET...G..IK..... 35 P........LRVSDGNIFVDEFHNDLKRLR.HNQEHSQEWIWEYQERIRKET...G..IK..... 36 -........ARKTGLITPKAGFDSDYDQAL.ADIRENEQSLLEYLDKQRSRL...G..CK..... 37 S........VWLKDGNVINHGFHPELDELR.RIQNHGDEFLLDLEAKERERT...G..LS..... 38 P........LSVKEGNLIKDGYNQKLDEYR.DASRNGKDWIARLEQQEREYT...G..IR..... 39 P........LSVKEGNLIKDGYNQKLDEYR.DASRNGKDWIARLEQQEREYT...G..IR..... 40 Kswt10rqkAINENIIVPQRGFDIEFDKSM.DRIQELEDELMEILMTYRKQF...K..CS..... 41 Kswt10rqkAINENIIVPQRGFDIEFDKSM.DRIQELEDELMEILMTYRKQF...K..CS..... 42 -........ARKTGLITPKAGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI...G..CR..... 43 P........HVITDGGIIRTGFDETLDKYR.CVLREGTSWIAEIEAKERENS...G..IS..... 44 P........VTLSDGNLIKRGFSASLDELH.RVRDNANEILKQYLAEERERT...G..IG..... 45 -........QVENHEFLVKASFDPNLTELR.EKMDELEKNMQGALGGAAREL...G..LDagk.. 46 Atsw11trrRYWSRRRVIAPGYHEELDEWR.ALADGATDYLDRLEIRERERT...G..LD..... 47 A........KVGDKTELFKDLSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL...K..LP..... 48 A........KVGDKTELFKDLSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL...K..LP..... 49 A........KVGDKTELFKDLSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL...K..LP..... 50 A........KVGDKTELFKDLSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL...K..LP..... 51 P........LHVKEGGLIREGVNAYLDELR.FIRDNAETYLREYEKKLRQET...G..IQ..... 52 P........LKLTDGGVIASEYDVELDELR.KLSNNADQFLIDLETRERESS...G..IS..... 53 A........KVGDKTELFKDLSDFPLIKKRkDEIQGVIDEIRMHLQEIRKIL...K..NP..... 54 -........AIERGEYLVKASFDSRLMELQ.QMMTELYSKMEELQFKCSQEL...N..LDgkn.. 55 -........AIERGEYLVKASFDSRLMELQ.QMMTELYSKMEELQFKCSQEL...N..LDgkn.. 56 A........KVGDKTELFKDLSDFPLIKKRkDEIQGVIDEIRMHLQEIRKIL...K..NP..... 57 P........NNLNDGGIIKYEFHPKIAQLN.DLINNKKLHVEKLKDQYRKET...R..IE..... 58 -........AHNSGRVIPHEGADEEYDCAC.KTVEEFESSLKKHLKEQRKLL...G..DA..... 59 -........ASEEGVFEPEIGFEAEYDTSQ.KYQSELKNELYALLEQYKKQL...R..CS..... 60 -........AHNSGRVIPHEGADEEYDCAC.KTVEEFESSLKKHLKEQRKLL...G..DA..... 61 -........ALDNHEFIIKPEFDDSLRIIR.KKLDRLRTDMDNEFAEAAEDL...G..QErek.. 62 -........QVENHEFLVKPSFDPNLSELR.EIMNDLEKKMQSTLISAARDL...G..LDpgk.. 63 P........LHVKEGGLIKPGVNAYLDELR.FIRENAEKLLKEYEKKLKKET...G..IQ..... 64 -........YEENNEFMIKVEFNEELGKIR.SKLDTLRDEIHSIHLDSAEDL...G..FDpdk.. 65 -........YEENNEFMIKVEFNEELGKIR.SKLDTLRDEIHSIHLDSAEDL...G..FDpdk.. 66 -........QLENGEYMISSNYDTKLASLK.DQKELLEQQIHELHKKTAIEL...D..LQvdk.. 67 P........LLKRDGGFVREGASAELDEMR.ALRDQSRRVIAGLQLQYCEET...G..IK..... 68 -........QLENGEYMISSSYDTKLASLK.DQKELLEQQIHELHKKTAIEL...D..LQvdk.. 69 Nsdk.....QVMDFFNLNNYDCSEGIIKIQ.RESESVRSQLKEELAEIRKYL...K..RP..... 70 Nsdk.....QVMDFFNLNNYDCSEGIIKIQ.RESESVRSQLKEELAEIRKYL...K..RP..... 71 -........ALDSHQYIIRAEFDEELLDLR.QRLDELQHSIFEEHKRVGSDL...H..QDtek.. 72 F........DLSEEPNDVDYELAQEIRELK.MSILMVRTEMDFHLQELRDYL...E..YP..... 73 F........DLSEEPNDVDYELAQEIRELK.MSILMVRTEMDFHLQELRDYL...E..YP..... 74 -........ALDSHQYIIRAEFDEELLDLR.QRLDELQHSIFEEHKRVGSDL...H..QDtek.. 75 -........AMKDGKIVPNAGCDEEYDEAL.NRVKEALNELNDYKDSVAKKY...S..CS..... 76 -........QLENGEYRISPLYSSDLGVLK.DELSVVENHINNLHVDTASDL...D..LSvdk.. 77 D........LL--DILITSSDQFPELAEAR.QAVLVIREKLDSSIASFRKKL...A..IR..... 78 Vwassaiq.LLNQRSYAVKSDSNGLLDVSR.QIYKEVKEEFFREVEDLTAKN...K..IN..... 79 Vwassaiq.LLNQRSYAVKSDSNGLLDVSR.QIYKEVKEEFFREVEDLTAKN...K..IN..... 80 -........AIERGEYLVKASFDSRLMELQ.QMMTELYSKMEELQFKCSQEL...N..LDgkn.. 81 -........ADRNGRFIPYEGCDPEFDATC.NAIEEIKSSLKEYLKEQRKLL...R..PA..... 82 D........LL--DILITSSDQFPELAEAR.QAVLVIREKLDSSIASFRKKL...A..IR..... 83 D........LL--DILITSSDQFPELAEAR.QAVLVIREKLDSSIASFRKKL...A..IR..... 84 -........SKIQGRVTVMNGIDEELDEIR.DTYENMPMVLTAIAKQEEARL...G..LPpys.. 85 -........SKIQGRVTVMNGIDEELDEIR.DTYENMPMVLTAIAKQEEARL...G..LPpys.. 86 -........QVENHEFLVKPSFDPNLSELK.---------------------...-..--..... 87 -........AAKTGVIAPQAGMDAEYDAAM.DSIGEVEKRLKTYLVEQERHF...G..CR..... 88 Rymkgcln.MRTQKCYAVRSNINEFLDIAR.RTYTEIVDDIAGMISQLGEKY...S..LP..... 89 Rymkgcln.MRTQKCYAVRSNINEFLDIAR.RTYTEIVDDIAGMISQLGEKY...S..LP..... 90 -........SLAENRFTVLPNIDPDIDAKK.RRLIGLPSFLTEVAQKELENL...DsrIP..... 91 -........SLAENRFTVLPNIDPDIDAKK.RRLIGLPSFLTEVAQKELENL...DsrIP..... 92 -........EKENKEIRVRVDFVPEIQEIS.EKLEQMERVAEKLRKKYSAKF...E..CD..... 93 -........SLAENRFTVLPNIDPEIDEKK.RRLMGLPSFLTEVARKELENL...DsrIP..... 94 -........SLAENRFTVLPNIDPEIDEKK.RRLMGLPSFLTEVARKELENL...DsrIP..... 95 D........------ELIKRGYDLKLDNLK.DLKINANKYIDQYLESERLLS...K..IN..... 96 -........SLAENRFTVLPNIDPEIDEKK.RRLMGLPSFLTEVARKELENL...DsrIP..... 97 P........ISVKDGGLFKVGFNTQLDE--.---------------------...-..--..... 98 D........LSDENTTRINPEFDDELMELE.EQRKSVVKAIESEHQRVMKVY...G..WTek... 99 L........MK------------------Q.KINEEEETEVIAQEAEEILQD...E..NA..... 100 LdgkknslhLQNTKCYAIRHFVAVQLDLAR.QTYEEIIRNVEETGAREIAEYfh.G..NS..... 101 Qwannste.LANQRANAVKSGVNGLLDVSR.RIRETLLEEVSELVAKLSEEL...E..IF..... 102 -........SKIQGRVTVMNGIDEELDEIR.DTYENMPMVLTAIAKQEEARL...G..LPpys.. 103 L........MK------------------Q.KINEEEETEVIAQEAEEILQD...E..NA..... 104 -........---------------------.---------------------...-..--..... 105 P........N--------------------.---------------------...-..--..... 106 -........KRIKTFIMLINGLRNGIDLLN.DLQRADHGILALY--------...-..--..... 107 -........KRIKTFIMLINGLRNGIDLLN.DLQRADHGILALY--------...-..--..... 108 P........N--------------------.---------------------...-..--..... 109 P........AVIRDGGVLKAGYDNELDEML.AISENAGQFLIDLEAREKART...G..LA..... 110 -........SRDTKTLTINTGVDNRLDECR.NIYNHLEGILLDVARETQIFLlnt-..--mpq14 111 -........SRDTKTLTINTGVDNRLDECR.NIYNHLEGILLDVARETQIFLlnt-..--mpq14 112 Kqna23kdeIFELRDFIVNPSFNTKLRKLH.DTYQGVWQ-------------...-..--..... 113 Kqna23kdeIFELRDFIVNPSFNTKLRKLH.DTYQGVWQ-------------...-..--..... 114 -........---------------------.---------------------...-..--..... 115 -........---------------------.---------------------...-..--..... 240 250 260 270 280 | | | | | 1 ...TLKVGYNAVFGYYLEVTRPYY....ERV......PKE....YRPVQTLKD...RQRYTLPEM 2 ...TLKVGYNNVHGFYIQVSRGQS....HLV......PPH....YVRRQTLKN...AERYIIEEL 3 ...TLKVGYNAVFGYYLEVTRPYY....ERV......PKE....YRPVQTLKD...RQRYTLPEM 4 ...TLKVGFNAVHGYYIQISRGQS....HLA......PIN....YMRRQTLKN...AERYIIPEL 5 ...TLKVGFNAVHGYYIQISRGQS....HLA......PIN....YMRRQTLKN...AERYIIPEL 6 ...TLKVGFNAVHGYYIQISRGQS....HLA......PIN....YMRRQTLKN...AERYIIPEL 7 ...NLKVGYNKAFGYYLSLPRSKS....EQA......PDN....YIRKQTLVN...EERYITPEL 8 ...NLKVGYNKAFGYYLSLPRSKS....EQA......PDN....YIRKQTLVN...EERYITPEL 9 ...NLKVGYNRIHGYFIELPRVQA....EQA......PAD....YIRRQTLKG...AERFITPEL 10 ...NLKVGYNRIHGYFIELPRVQA....EQA......PAD....YIRRQTLKG...AERFITPEL 11 ...NLKVGYNRIHGYYIELPRVQA....EQA......PAD....YIRRQTLKG...AERFITPEL 12 ...TLKIGFNAVHGYYIQISQGQA....HKA......PIH....YVRRQTLKN...AERYIIPEL 13 ...TLKVGYNAVFGYYLEVTRPYY....EKV......PQE....YRPVQTLKD...RQRYTLPEM 14 ...TLKVGYNAVFGYYLEVTRPYY....EKV......PQE....YRPVQTLKD...RQRYTLPEM 15 ...TLKVGYNAVFGYYLEVTRPYY....EKV......PQE....YRPVQTLKD...RQRYTLPEM 16 ...QIKLDSSAQFGYYFRVTCKEE....KVLrn....NKN....FSTVDIQKN...GVKFTNSKL 17 ...QIKLDSSAQFGYYFRVTCKEE....KVLrn....NKN....FSTVDIQKN...GVKFTNSKL 18 ...QIKLDSSAQFGYYFRVTCKEE....KVLrn....NKN....FSTVDIQKN...GVKFTNSKL 19 ...TLKVGYNAVFGYYLEVTRPYY....EKV......PQE....YRPVQTLKD...RQRYTLPEM 20 ...QIKLDSSAQFGYYFRVTCKEE....KVLrn....NKN....FSTVDIQKN...GVKFTNSEL 21 ...QIKLDSSAQFGYYFRVTCKEE....KVLrn....NKN....FSTVDIQKN...GVKFTNSEL 22 ...QIKLDSSAQFGYYFRVTCKEE....KVLrn....NKN....FSTVDIQKN...GVKFTNSEL 23 ...TLKVGYNAVHGYYIQISRGQS....HLA......PIN....YVRRQTLKN...AERYIIPEL 24 ...KLRVGYNQVFGYYIEVTKANL....DKI......PDD....YERKQTLVN...SERFITPEL 25 ...KLKVCYAQALGYYIEVASNLA....PQL......PKE....FIRRQSRLH...AERFTTQEL 26 ...SIVYWGIGRNRYQLEIPENFA....TRNl.....PEE....YELKSTKKG...CKRYWTKTI 27 ...TIVYWGIGRNRYQLEIPENFT....TRNl.....PEE....YELKSTKKG...CKRYWTKTI 28 ...TIVYWGIGRNRYQLEIPENFT....TRNl.....PEE....YELKSTKKG...CKRYWTKTI 29 ...TIVYWGIGRNRYQLEIPENFT....TRNl.....PEE....YELKSTKKG...CKRYWTKTI 30 ...KLRVGYNQVFGYYIEVTKANL....DKI......PDD....YERKQTLVN...SERFITPEL 31 ...TIVYWGIGRNRYQLEIPENFT....TRNl.....PEE....YELKSTKKG...CKRYWTKTI 32 ...KLKVCYAQALGYYIEVASSFA....PQL......PKE....FIRRQSRLH...AERFTTQEL 33 ...TLKVEFNRVHGFYIELSKTQA....EQA......PAD....YQRRQTLKN...AERFITPEL 34 ...KLKICFAQALGYYIEVSSEFA....PQL......PKD....FIRRQSRLH...AERFTTIEL 35 ...KLKICFAQALGYYIEVSSEFA....PQL......PKD....FIRRQSRLH...AERFTTIEL 36 ...SIVYWGIGRNRYQLEIPENFA....TRNl.....PEE....YELKSTKKG...CKRYWTKTI 37 ...TLKVEFNRVHGFYIELSKTQA....EQA......PAD....YQRRQTLKN...AERFITPEL 38 ...SLKVGFNKVFGYYIEVTKANL....HLL......EEGr...YERNETLTN...AERYITPEL 39 ...SLKVGFNKVFGYYIEVTKANL....HLL......EEGr...YERNETLTN...AERYITPEL 40 ...NIQYKDSGKEIYTIEIPISAT....KNV......PSN....WVQMAANKT...YKRYYSDEV 41 ...NIQYKDSGKEIYTIEIPISAT....KNV......PSN....WVQMAANKT...YKRYYSDEV 42 ...TIVYWGIGRNRYQLEIPENFT....TRNl.....PEE....YELKSTKKG...CKRYWTKTI 43 ...TLKIDYNKKDGYYFHVTNSQL....GNV......PAH....FFRKATLKN...SERFGTEEL 44 ...TLKMKYNRMLGHFLEVSKGHL....SAV......PAH....FIRRRSLSN...ADRFTTEQL 45 ...SIKLESNSQIGHYFRVTCKEE....KALrn....NKK....FTTIDIQKN...GVRFTNSKL 46 ...TLKVGYNAVHGYYIQISRGQS....HLA......PIN....YVRRQTLKN...AERYIIPEL 47 ...SLQYVTVSGQEFMIEIKNSAV....SCI......PAD....WVKVGSTKA...VSRFHPPFI 48 ...SLQYVTVSGQEFMIEIKNSAV....SCI......PAD....WVKVGSTKA...VSRFHPPFI 49 ...SLQYVTVSGQEFMIEIKNSAV....SCI......PAD....WVKVGSTKA...VSRFHPPFI 50 ...SLQYVTVSGQEFMIEIKNSAV....SCI......PAD....WVKVGSTKA...VSRFHPPFI 51 ...SLKIGYNKVMGYYIEVTKPNL....KYV......PSY....FRRRQTLSN...SERFTTEEL 52 ...TLKVGYNRVHGYYIEISKGQA....DKA......PVH....YTRRQTLTN...AERYITEEL 53 ...SAQYVTVSGQEFMIEIKNSAV....SCI......PTD....WVKVGSTKA...VSRFHSPFI 54 ...QVKLESVAKLGHHFRITVKDD....SVLrk....NKN....YRIVDVIKG...GVRFTSDKL 55 ...QVKLESVAKLGHHFRITVKDD....SVLrk....NKN....YRIVDVIKG...GVRFTSDKL 56 ...SAQYVTVSGQEFMIEIKNSAV....SCI......PTD....WVKVGSTKA...VSRFHSPFI 57 ...SLKISHNNVLGFFIDITPKNV....NKIl.....DPK....FIHRQTTIN...SVRYTTYEL 58 ...SINYVTVGKDEYLLEVPESLS....GSV......PHD....YELCSSKKG...VSRYWTPTI 59 ...SLNFKNIGKEVYQVEVPSDV-....-KV......PVN....WCKMSGTKK...TNRYYNDEL 60 ...SINYVTVGKDEYLLEVPESLS....GSV......PHD....YELCSSKKG...VSRYWTPTI 61 ...KIFLENHKVHGWCMRLTRTEA....GCIrn....NSR....YLECSTQKN...GVYFTTKTL 62 ...QIKLDSSAQFGYYFRVTCKE-....---......---....---------...--------- 63 ...SLKIGYNKVMGYYIEVTKANV....KYV......PEH....FRRRQTLSN...AERYTTEEL 64 ...KLKLENHHLHGWCMRLTRNDA....KEL......RKHkk..YIELSTVKA...GIFFSTKQL 65 ...KLKLENHHLHGWCMRLTRNDA....KEL......RKHkk..YIELSTVKA...GIFFSTKQL 66 ...ALKLDKAAQFGHVFRITKKEE....PKI......RKKlttqFIVLETRKD...GVKFTNTKL 67 ...SLKIKHNNVLGYFIEVTAGNA....GSMtdtdagRAR....FIHRQTMAN...AMRFTTTEL 68 ...ALKLDKAAQFGHVFRITKKEE....PKI......RKKlttqFIVLETRKD...GVKFTNTKL 69 ...YLNFR--DEVDYLIEVKNSQI....KDL......PDD....WIKVNNTKM...VSRFTTPRT 70 ...YLNFR--DEVDYLIEVKNSQI....KDL......PDD....WIKVNNTKM...VSRFTTPRT 71 ...KLHLEQHHLYGWCLRLTRTEA....GCLrgr...SSH....YTELSTQKN...GVYFTTKRL 72 ...NLEFSIWGNVKFCIEVSKGC-....KKI......PPD....WIKLSSTRS...LFRFHTPKI 73 ...NLEFSIWGNVKFCIEVSKGC-....KKI......PPD....WIKLSSTRS...LFRFHTPKI 74 ...KLHLEQHHLYGWCLRLTRTEA....GCLrgr...SSH....YTELSTQKN...GVYFTTKRL 75 ...-IKFVDSGKVKYLLEMPEN--....TKV......SSS....FELKSRRKG...FIRYSTPDS 76 ...QLKLEK-GSLGHVFRMSKKEE....QKV......RKKltgsYLIIETRKD...GVKFTNSKL 77 ...NLEFLQVSGITHLIELPVD--....SKV......PMN....WVKVNSTKK...TIRYHPPEI 78 ...-LDHNYDSARGFYLRIKRQEF....TDDvatl..PDV....FISRTIKKN...YIECTTLNI 79 ...-LDHNYDSARGFYLRIKRQEF....TDDvatl..PDV....FISRTIKKN...YIECTTLNI 80 ...QVKLESVAKLGHHFRITVKDD....SVLrk....NKN....YRIVDVIKG...GVRFTSDKL 81 ...SVNYVNVGKDMYLIEVPESLG....GSV......PRN....YELQSTKKG...FYRYWTPEL 82 ...NLEFLQVSGITHLIELPVD--....SKV......PMN....WVKVNSTKK...TIRYHPPEI 83 ...NLEFLQVSGITHLIELPVD--....SKV......PMN....WVKVNSTKK...TIRYHPPEI 84 ...NVACVYIPLVGFVLSVPRDY-....---......---....---------...--------- 85 ...NVACVYIPLVGFVLSVPRDY-....---......---....---------...--------- 86 ...---------------------....---......---....---------...--------- 87 ...-ITYFGSDKKRYQLDVPESHA....SKA......NKS....YTLEGQTKGkkpSRRYTTAET 88 ...-LRTSFSSARGFFIQMTTDCIalpsDQL......PSE....FIKISKVKN...SYSFTSADL 89 ...-LRTSLSSVRGFFIQMTTDCIalpsDQL......PSE....FIKISKVKN...SYSFTSADL 90 ...SCSVIYIPLIGFLLSIPR---....---......---....---------...--------- 91 ...SCSVIYIPLIGFLLSIPR---....---......---....---------...--------- 92 ...NLKLDKNSQYGFYFRVTLKEE....KSI......RKKdv..HILETTKGS...GVKFSVGEL 93 ...SCSVIYIPLIGFLLSIPR---....---......---....---------...--------- 94 ...SCSVIYIPLIGFLLSIPR---....---......---....---------...--------- 95 ...NLKIRKTNNRGLFFEVTKSNY....AQV......PPH....FMESQALNS...SKRYKTEKL 96 ...SCSVIYIPLIGFLLSIPR---....---......---....---------...--------- 97 ...---------------------....---......---....---------...--------- 98 ...QLKCEYHTTYGYVFRVTRKED....QQVrt....SKE....LITVSTSKD...GVRFVSERL 99 ...QVEIVKKS-----LSSEFDIR....QSF......KEN....WVVKSNFNN...NLRKLHEKL 100 ...SVRLSFSQSRGFHYTFVTRQA....ESVti....PRY....FLDVFRNRT...TVTFNSRKV 101 ...-MEYRFEISRGFFIKIKGNNT....DINsl....PEV....LINRVKKRK...TIECTTIEL 102 ...NVACVYIPLVGFVLSVPRDY-....---......---....---------...--------- 103 ...QVEIVKKS-----LSSEFDIR....QSF......KEN....WVVKSNFNN...NLRKLHEKL 104 ...---------------------....---......---....---------...--------- 105 ...---------------------....---......---....---------...--------- 106 ...--KIVDIPSLSYLPELIHKFE....ERM......QNE....FP-------...--------- 107 ...--KIVDIPSLSYLPELIHKFE....ERM......QNE....FP-------...--------- 108 ...---------------------....---......---....---------...--------- 109 ...NLKVGYNRVHGYFIELPTKQA....EQA......PGD....YIRRQTLKG...AERFITPEL 110 lekLVNAVYIPQLGYLVTISVLME....PLLdgip..NLQ....WEEIFRSSE...NIYFKNGRV 111 lekLVNAVYIPQLGYLVTISVLME....PLLdgip..NLQ....WEEIFRSSE...NIYFKNGRV 112 ...---------------------....---......---....---------...--------- 113 ...---------------------....---......---....---------...--------- 114 ...---------------------....---......---....---------...--------- 115 ...---------------------....---......---....---------...--------- 290 300 | | 1 KEKEREVYRLEALIRRREE 2 KQHEDKVLNSKSRALALE- 3 KEKEREVYRLEALIRRREE 4 KEYEDKVLTSKGKALALE- 5 KEYEDKVLTSKGKALALE- 6 KEYEDKVLTSKGKALALE- 7 KERETRILTAQADLNQLE- 8 KERETRILTAQADLNQLE- 9 KAFEDKALSAQSRALARE- 10 KAFEDKALSAQSRALARE- 11 KAFEDKALSAKSRALARE- 12 KEYEDKVLKSKGAALALE- 13 KERERELYRLEALIKRREE 14 KERERELYRLEALIKRREE 15 KERERELYRLEALIKRREE 16 TSLNEEYTKNKTEYEEAQD 17 TSLNEEYTKNKTEYEEAQD 18 TSLNEEYTKNKTEYEEAQD 19 KERERELYRLEALIKRREE 20 SSLNEEYTKNKGEYEEAQD 21 SSLNEEYTKNKGEYEEAQD 22 SSLNEEYTKNKGEYEEAQD 23 KEYEDKVLTSKGKALALE- 24 KEFETKIMAAKERIEELE- 25 QQFQDEVFSVEDKLQTLE- 26 EKKLANLINAEER------ 27 EKKLANLINAEE------- 28 EKKLANLINAEE------- 29 EKKLANLINAEE------- 30 KEFETKIMAAKERIEELE- 31 EKKLANLINAEE------- 32 QQFQDEVFSVEDKLQTLE- 33 KAFEDKVLTAQEQALALE- 34 QQFQDDMSNISEKLQTLE- 35 QQFQDDMSNISEKLQTLE- 36 EKKLANLINAEER------ 37 KAFEDKVLTAQEQALALE- 38 KEKEALILEAENNICELE- 39 KEKEALILEAENNICELE- 40 RALARSMAEAKEIHKTLEE 41 RALARSMAEAKEIHKTLEE 42 EKKLANLINAEE------- 43 ARIEGDMLEAREKSANL-- 44 SELEAKLARAREGLVSFE- 45 SSLSEEYMRNREEYEEAQ- 46 KEYEDKVLTSKGKALALE- 47 VESYRRLNQLREQ------ 48 VESYRRLNQLREQ------ 49 VESYRRLNQLREQ------ 50 VESYRRLNQLREQ------ 51 QRLEEKILSAQTRINDLE- 52 KAFEDKVLSARDRALVRE- 53 VENYRHLNQLREQ------ 54 EGYADEFASCRTRYEE--- 55 EGYADEFASCRTRYEE--- 56 VENYRHLNQLREQ------ 57 QNLENELVNAQTLVIRLE- 58 KKLLKELSQAKSE------ 59 RKKIKKLLEAEEL------ 60 KKLLKELSQAKSE------ 61 QALRREFDQLSQNYN---- 62 ------------------- 63 QRLEEKILSAQTRINELE- 64 KSIANETNILQKEYD---- 65 KSIANETNILQKEYD---- 66 KKLGDQYQSVVDDYRSCQ- 67 AELETKIANAADRALAIE- 68 KKLGDQYQSVVDDYRSCQ- 69 QKLTQKLEYYKDLL----- 70 QKLTQKLEYYKDLL----- 71 HSLNNSYMDHQKS------ 72 QSLLIELSSHEEN------ 73 QSLLIELSSHEEN------ 74 HSLNNS------------- 75 EQLVAALDAVEKE------ 76 KNLSDQYQALFGEYTSCQ- 77 VAGLDEL------------ 78 IKKNARLKEVMEEI----- 79 IKKNARLKEVMEEI----- 80 EGYADEFASCRTRYEE--- 81 KELILELSKAES------- 82 VAGLDEL------------ 83 VAGLDEL------------ 84 ------------------- 85 ------------------- 86 ------------------- 87 RALLKDMQHAE-------- 88 IKMNERCQES--------- 89 IKMNERCQES--------- 90 ------------------- 91 ------------------- 92 SDINDEFLEFHLKYTRAE- 93 ------------------- 94 ------------------- 95 ISLEVDINNAEDNVVAFE- 96 ------------------- 97 ------------------- 98 SSLSEQYKGIRK------- 99 QSLFASYDKLQEDL----- 100 IAYNDRLEQVVAE------ 101 MKQSSRYNDIVSEIT---- 102 ------------------- 103 QSLFASYDKLQEDL----- 104 ------------------- 105 ------------------- 106 ------------------- 107 ------------------- 108 ------------------- 109 KAFEDKALSAKSRALARE- 110 LELDE-------------- 111 LELDE-------------- 112 ------------------- 113 ------------------- 114 ------------------- 115 -------------------