; SAM: prettyalign v3.2 (July 31, 2000) compiled 07/31/00_16:52:38 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequences correspond to the following labels: ; 1 gi|9864530|gb|AAG00261.1|_10:607 ; 2 gi|1174416|sp|P43248|MSH2_DROME_8:567 ; 3 gi|7287834|gb|AAF44872.1|AE003406_77_24:571 ; 4 gi|7298155|gb|AAF53392.1|_24:508 ; 5 gi|6324482|ref|NP_014551.1|_19:592 ; 6 gi|172002|gb|AAA34802.1|_19:592 ; 7 gi|3914053|sp|O13396|MSH2_NEUCR_14:562 ; 8 gi|7522263|pir||T39832_20:579 ; 9 gi|4151103|emb|CAA07342.1|_20:587 ; 10 gi|1709122|sp|P54275|MSH2_RAT_19:575 ; 11 gi|6678938|ref|NP_032654.1|_19:575 ; 12 gi|726086|gb|AAA75027.1|_19:575 ; 13 gi|2135744|pir||I37550_19:575 ; 14 gi|7448104|pir||I64827_19:575 ; 15 gi|1000883|gb|AAB59571.1|_19:529 ; 16 gi|4557761|ref|NP_000242.1|_19:575 ; 17 gi|1000877|gb|AAB59569.1|_19:423 ; 18 gi|1000879|gb|AAB59570.1|_19:482 ; 19 gi|1000873|gb|AAB59567.1|_19:338 ; 20 gi|1000875|gb|AAB59568.1|_19:377 ; 21 gi|1079288|pir||S53609_19:573 ; 22 gi|4775576|emb|CAB42554.1|_29:572 ; 23 gi|3914056|sp|O24617|MSH2_ARATH_27:571 ; 24 gi|4139230|gb|AAD04176.1|_27:571 ; 25 gi|3886083|gb|AAC78226.1|_18:547 ; 26 gi|6320047|ref|NP_010127.1|_53:531 ; 27 gi|1582703|prf||2119252A_48:531 ; 28 gi|5815430|gb|AAD52669.1|AF178755_1_50:495 ; 29 gi|4336728|gb|AAD17920.1|_148:585 ; 30 gi|4505251|ref|NP_002431.1|_148:585 ; 31 gi|730066|sp|P40965|MSH4_YEAST_97:543 ; 32 gi|6321109|ref|NP_011187.1|_97:543 ; 33 gi|6319935|ref|NP_010016.1|_152:725 ; 34 gi|448278|prf||1916402A_152:724 ; 35 gi|118951|sp|P20585|MSH3_HUMAN_220:798 ; 36 gi|4505249|ref|NP_002430.1|_211:789 ; 37 gi|110917|pir||A32495_175:753 ; 38 gi|400971|sp|P13705|MSH3_MOUSE_175:753 ; 39 gi|387849|gb|AAB60711.1|_175:753 ; 40 gi|1083296|pir||JC4019_189:788 ; 41 gi|6981224|ref|NP_034959.1|_143:376 ; 42 gi|3319876|emb|CAA07684.1|_93:712 ; 43 gi|7547005|gb|AAF63754.1|AF242852_1_65:256 ; 44 gi|7269404|emb|CAB81364.1|_93:725 ; 45 gi|3914062|sp|O65607|MSH3_ARATH_93:725 ; 46 gi|1076927|pir||S22569_4:572 ; 47 gi|135075|sp|P26359|SWI4_SCHPO_94:664 ; 48 gi|6226648|sp|O04716|MSH6_ARATH_367:977 ; 49 gi|2104549|gb|AAB57798.1|_372:1015 ; 50 gi|7294307|gb|AAF49656.1|_249:858 ; 51 gi|2506881|sp|P54276|MSH6_MOUSE_393:1021 ; 52 gi|6754744|ref|NP_034960.1|_393:1021 ; 53 gi|7512474|pir||JC5839_394:1024 ; 54 gi|1709123|sp|P52701|MSH6_HUMAN_394:1024 ; 55 gi|7512473|pir||JC5840_394:1024 ; 56 gi|4504191|ref|NP_000170.1|_394:1024 ; 57 gi|1082386|pir||A56742_326:956 ; 58 gi|7331984|gb|AAF60672.1|_840:1459 ; 59 gi|7492209|pir||T41262_362:924 ; 60 gi|6320302|ref|NP_010382.1|_299:877 ; 61 gi|1588283|prf||2208298A_299:877 ; 62 gi|7012942|gb|AAF35250.1|AF227632_1_1:276 ; 63 gi|7490460|pir||T37626_49:190 ; 64 gi|6166561|sp|O13921|MSH1_SCHPO_50:578 ; 65 gi|7522430|pir||T38256_2:417 ; 66 gi|172000|gb|AAA34801.1|_68:557 ; 67 gi|6321912|ref|NP_011988.1|_68:557 ; 68 T0116-1-500 ; 69 gi|2497995|sp|Q56215|MUTS_THEAQ_3:500 ; 70 gi|2145507|pir||S62790_18:507 ; 71 gi|2497996|sp|Q56239|MUTS_THETH_10:508 ; 72 gi|1871501|dbj|BAA09880.1|_10:508 ; 73 gi|7387928|sp|Q9ZIX6|MUTS_THECA_8:506 ; 74 gi|3914079|sp|O66652|MUTS_AQUAE_4:518 ; 75 gi|3024198|sp|P70755|MUTS_AQUPY_6:518 ; 76 gi|1619909|gb|AAB16999.1|_3:501 ; 77 gi|6226653|sp|P74926|MUTS_THEMA_3:501 ; 78 gi|7243293|dbj|BAA92687.1|_38:229 ; 79 gi|2072992|gb|AAC46142.1|_1:130 ; 80 gi|7448108|pir||S74860_56:595 ; 81 gi|7404405|sp|P73769|MUTS_SYNY3_22:561 ; 82 gi|123080|sp|P10564|HEXA_STRPN_4:509 ; 83 gi|7328284|emb|CAB82466.1|_2:419 ; 84 gi|1002520|gb|AAB19235.1|_1:506 ; 85 gi|7404403|sp|P49849|MUTS_BACSU_3:512 ; 86 gi|9106782|gb|AAF84525.1|AE003995_7_39:565 ; 87 gi|9654962|gb|AAF93703.1|_7:531 ; 88 gi|79102|pir||A28668_7:524 ; 89 gi|417330|sp|P10339|MUTS_SALTY_7:525 ; 90 gi|127556|sp|P23909|MUTS_ECOLI_6:524 ; 91 gi|4887554|emb|CAB43497.1|_6:524 ; 92 gi|1592569|gb|AAB97931.1|_6:524 ; 93 gi|1171081|sp|P44834|MUTS_HAEIN_3:526 ; 94 gi|7108493|gb|AAF36440.1|AF126491_1_4:523 ; 95 gi|7229490|gb|AAF42850.1|_4:523 ; 96 gi|127555|sp|P27345|MUTS_AZOVI_3:523 ; 97 gi|7379009|emb|CAB83555.1|_4:518 ; 98 gi|7227419|gb|AAF42468.1|_4:518 ; 99 gi|8473172|sp|P56883|MUTS_RHIME_21:566 ; 100 gi|6647605|sp|Q9ZDM9|MUTS_RICPR_13:553 ; 101 gi|6093453|sp|O83348|MUTS_TREPA_5:530 ; 102 gi|7190210|gb|AAF39048.1|_4:526 ; 103 gi|7387913|sp|O84797|MUTS_CHLTR_4:526 ; 104 gi|7387924|sp|Q9Z6W5|MUTS_CHLPN_5:532 ; 105 gi|7189834|gb|AAF38705.1|_5:532 ; 106 gi|3914075|sp|O51737|MUTS_BORBU_4:516 ; 107 gi|6224917|gb|AAF06013.1|AF193018_1_255:726 ; 108 gi|9294039|dbj|BAB01996.1|_255:726 ; 109 gi|4775580|emb|CAB42556.1|_46:498 ; 110 gi|4775578|emb|CAB42555.1|_353:805 ; 111 gi|3914061|sp|O63852|MSHM_SARGL_71:565 ; 112 gi|3831701|gb|AAC70065.1|_58:505 ; 113 gi|8515837|gb|AAF76200.1|_58:505 ; 114 gi|3914066|sp|Q19272|MSH5_CAEEL_58:606 ; 115 gi|3986757|gb|AAC84154.1|_15:450 ; 116 gi|7305281|ref|NP_038628.1|_15:450 ; 117 gi|3108220|gb|AAC62533.1|_44:451 ; 118 gi|4505253|ref|NP_002432.1|_44:451 ; 119 gi|5725250|emb|CAB52406.1|_44:468 10 20 30 40 50 | | | | | 1 ----------------........LQAFTAVGGDDKACVRLFSRGGstpgCYVLGS.WAGFIARE 2 ---TYPEYGHKCASNF........IKFHAKLGEKPATTVRFFDHTD....RYTVHGsDDCELVAK 3 ---------------F........IKFHAKLGEKPATTVRFFDHTD....RYTVHGsDDCELVAK 4 ---------------F........IKFHAKLGEKPATTVRFFDHTD....RYTVHGsDDCELVAK 5 ---------------F........YKKYTGLPKKPLKTIRLVDKGD....YYTVIG.SDAIFVAD 6 ---------------F........YKKYTGLPKKPLKTIRLVDKGD....YYTVIG.SDAIFVAD 7 --------------GF........IRFYKSLPQLGEEAIRIFDRGD....WYTAHG.DDATFIAR 8 ----------------........--NFYEKMPKDTNTVRVFDRGE....FYVAIG.EDASFVAQ 9 ----------------........--NFYEKMPKDTNTVRVFDRGE....FYVAIG.EDASFVAQ 10 ---------------F........VRFFEGMPEKPSTTVGLFDRGD....FYTAHG.EDALLAAR 11 ---------------F........VRFFEGMPEKPSTTVRLFDRGD....FYTAHG.EDALLAAR 12 ---------------F........VRFFEGMPEKPSTTVRLFDRGD....FYTAHG.EDALLAAR 13 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 14 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 15 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 16 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 17 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 18 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 19 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 20 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 21 ---------------F........LHFYQSMPEKPDTTVRVFDRND....YYTVHG.GDALFAAK 22 ----------------........---FFKKLPQDPRAVRLFDRRD....YYTAHG.ENATFIAR 23 ----------------........---FYKTLPNDTRAVRFFDRKD....YYTAHG.ENSVFIAK 24 ----------------........---FYKTLPNDTRAVRFFDRKD....YYTAHG.ENSVFIAK 25 ----------------........-------KSKSPNTIAIFSRGE....YFSVYG.DDATFVAT 26 ----------------........----------------------....------.-------- 27 ----------------........----------------------....------.-------- 28 ----------------........----------------------....------.-------- 29 ----------------........----------------------....------.-------- 30 ----------------........----------------------....------.-------- 31 ----------------........----------------------....------.-------- 32 ----------------........----------------------....------.-------- 33 ---KARKSPTAKLTPL........DKQVKDLKMHHRDKVLVIRVGY....KYKCFA.EDAVTVSR 34 ---KARKSPTAKLTPL........DKQVKDLKMHHRDKVLVIRVGY....KY-CFA.EDAVTVSR 35 ---SANKRSKSIYTPL........ELQYIEMKQQHKDAVLCVECGY....KYRFFG.EDAEIAAR 36 ---SANKRSKSIYTPL........ELQYIEMKQQHKDAVLCVECGY....KYRFFG.EDAEIAAR 37 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECGY....KYRFFG.EDAEIAAR 38 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECGY....KYRFFG.EDAEIAAR 39 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECGY....KYRFFG.EDAEIAAR 40 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECGY....KYRFFG.EDAEIAAR 41 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECGY....KYRFFG.EDAEIAAR 42 -EYVPETSSSRKYTPL........EQQVVELKSKYPDVVLMVEVGY....RYRFFG.EDAEIAAR 43 -----------KYTPL........EQQVVELKRKHPDVILMVEVGY....RYRFFG.EDAEIAAR 44 -EYVPETSSSRKYTPL........EQQVVELKSKYPDVVLMVEVGY....RYRFFG.EDAEIAAR 45 -EYVPETSSSRKYTPL........EQQVVELKSKYPDVVLMVEVGY....RYRFFG.EDAEIAAR 46 -----PTKQKSVFTPL........EQQYLELKKNYQETILAIEVGY....KFRFFG.KDAKIASE 47 ---SKPTKQKSVFTPL........EQQYLELKKNYQETILAIEVGY....KFRFFG.KDAKIASE 48 RTLYLPPDFVKKLTGG........QRQWWEFKAKHMDKVVFFKMGK....FYELFE.MDAHVGAK 49 RTLYLPPDFVKKLTGGqvrrahgnLRQWWEFKAKHMDKVVFFKMGK....FYELFE.MDAHVGAK 50 STLHVPEKFLNGLSPG........VRQWWVLKSDNYDCVLFFKVGK....FYELYH.MDADVGVN 51 TTLYVPEEFLNSCTPG........MRKWWQLKSQNFDLVIFYKVGK....FYELYH.MDAVIGVS 52 TTLYVPEEFLNSCTPG........MRKWWQLKSQNFDLVIFYKVGK....FYELYH.MDAVIGVS 53 STLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVGK....FYELYH.MDALIGVS 54 STLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVGK....FYELYH.MDALIGVS 55 STLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVGK....FYELYH.MDALIGVS 56 STLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVGK....FYELYH.MDALIGVS 57 STLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVGK....FYELYH.MDALIGVS 58 KTLWVPPDFHQKQTPG........HRQWWTMKSQHFDTILLFKVGK....FYETYH.MDAVEVVR 59 RTLYIPPSAWATFKPF........EKQFWKIKKDLMDTVVFFQKGK....FYELYE.NDAAIGHQ 60 RTLYIPSSAWNKFTPF........EKQYWEIKSKMWDCIVFFKKGK....FFELYE.KDALLANA 61 RTLYIPSSAWNKFTPF........EKQYWEIKSKMWDCIVFFKKGK....EFELYE.KDALLANA 62 ----------------........----------------------....------.-------- 63 -LDFIRPKEKVTLPPL........LKEVSFQQKKFADCVLLTKVGN....FYEMYF.EQAEKIGP 64 --DFIRPKEKVTLPPL........LKEVSFQQKKFADCVLLTKVGN....FYEMYF.EQAEKIGP 65 ----------------........----------------------....------.-------- 66 -KLSSTEPSKASLPPS........LQYVRDLMDLYKDHVVLTQMGS....FYELYF.EQAIRYAP 67 -KLSSTEPSKASLPPS........LQYVRDLMDLYKDHVVLTQMGS....FYELYF.EQAIRYAP 68 MEGMLKGEGPGPLPPL........LQQYVELRDQYPDYLLLFQVGD....FYECFG.EDAERLAR 69 --GMLKGEGPGPLPPL........LQQYVELRDQYPDYLLLFQVGD....FYECFG.EDAERLAR 70 ----------PPLPPL........LQQYVELRDRYPDYLLLFQVGD....FYECFG.EDAERLAR 71 -EGMLKGEGPGPLPPL........LQQYVELRDRYPDYLLLFQVGD....FYECFG.EDAERLAR 72 -EGMLKGEGPGPLPPL........LQQYVELRDRYPDYLLLFQVGD....FYECFG.EDAERLAR 73 --VMLKGEGPGPLPPL........LQQYVELRDRYPDYLLLFQVGD....FYECFG.EDAERLAR 74 --------SEKELTPM........LSQYHYFKNQYPDCLLLFRLGD....FYELFY.EDAYIGSK 75 ----------KELTPM........LAQYHQFKSMYPDCLLLFRLGD....FYELFY.EDAVVGSK 76 ------------VTPL........MEQYLRIKEQYKDSILLFRLGD....FYEAFF.EDAKIVSK 77 ------------VTPL........MEQYLRIKEQYKDSILLFRLGD....FYEAFF.EDAKIVSK 78 ----------------........----------------------....------.-------- 79 ----------------........----------------------....---CFF.QDAIVVAR 80 ---------RQKLTPM........FQHYTEVKEQYQGALLLYRVGD....FFECFF.QDAVIIAR 81 ---------RQKLTPM........FQHYTEVKEQYQGALLLYRVGD....FFECFF.QDAVIIAR 82 ----------EKLSPG........MQQYVDIKKQYPDAFLLFRMGD....FYELFY.EDAVNAAQ 83 ----------SNVTPM........MQQYLKIKSEYQDCLLFFRLGD....FYEMFY.EDAKEASR 84 ---------------M........IQQYLKIKAEHQDAFLFFRLGD....FYEMFF.EDAKKASQ 85 -----------GYTPM........IQQYLKIKAEHQDAFLFFRLGD....FYEMFF.EDAKKASQ 86 --KPEGGKGMAEHTPL........MKQYFAAKAEYPDLLLFFRMGD....FYELFH.QDARKAAR 87 ----SPSESLSHHTPM........MQQYLRLKAENPDILLFYRMGD....FYELFY.DDAKRASE 88 -------KDFSNHTPM........MQQYLKLKAQHPEILLFYRMGD....FYELFY.DDAKRASQ 89 -------KDFSNHTPM........MQQYLKLKAQHPEILLFYRMGD....FYELFY.DDAKRASQ 90 --------NFDAHTPM........MQQYLRLKAQHPEILLFYRMGD....FYELFY.DDAKRASQ 91 --------NFDAHTPM........MQQYLKLKAQHPEILLFYRMGD....FYELFY.DDAKRASQ 92 --------NFDAHTPM........MQQYLKLKAQHPEILLFYRMGD....FYELFY.DDAKRASQ 93 -----SEENFQQHTPM........MQQYLKLKAENPDILLFYRMGD....FYELFY.DDAKKAAA 94 ---------LSQHTPM........MQQYFKLKHQHPDQLMFYRMGD....FYELFY.EDAKKAAK 95 ---------LSQHTPM........MQQYFKLKHQHPDQLMFYRMGD....FYELFY.EDAKKAAK 96 --------SLSQHTPM........MQQYWKLKREHPDQLMFYRMGD....FYELFY.EDAKKAAK 97 ----------SAVSPM........MQQYLGIKAQHTDKLVFYRMGD....FYEMFF.DDAVEAAK 98 ----------SAVSPM........MQQYLGIKAQHTDKLVFYRMGD....FYEMFF.DDAVEAAK 99 ----ASEESRSTATPM........MEQFIEIKANNPDSLLFYRMGD....FYELFF.QDAVEASR 100 -----QKYNYNVATKM........MQQYLDIKFAHLDCLLLFRMGD....FYELFY.EDAILASN 101 ----------ASDTPL........MRQYHAIRAQHPDAVLFFRLGD....FYEMFD.SDALHVST 102 -----------KLTPM........MQQWHQCKEQAGDCLLLFRLGE....FYEAFF.DDALVLAQ 103 -----------KLTPM........MQQWHQCKEQAGDCLLLFRLGE....FYEAFF.DDALILAQ 104 -----------KPTPM........MEQWHQCKEKAGDSVLLFRMGD....FYEAFY.DDAVLLSQ 105 -----------KPTPM........MEQWHQCKEKAGDSVLLFRMGD....FYEAFY.DDAVLLSQ 106 -----------NVTPM........IRQYLDIKKKYKDAVLFFRVGS....FYEMFF.DDAIEVSK 107 KTLHIPPDVFKKMSAS........QKQYWSVKSEYMDIVLFFKVGK....FYELYE.LDAELGHK 108 KTLHIPPDVFKKMSAS........QKQYWSVKSEYMDIVLFFKVGK....FYELYE.LDAELGHK 109 STLFIPPDALRKMSTS........QKQYWNIKCKYMDVVLFFKVGK....FYELYE.LDAEIGQK 110 STLFIPPDALRKMSTS........QKQYWNIKCKYMDVVLFFKVGK....FYELYE.LDAEIGQK 111 ----------------........----------------------....------.---EQVAS 112 ----------------........----------------------....------.-------- 113 ----------------........----------------------....------.-------- 114 ----------------........----------------------....------.-------- 115 ----------------........----------------------....------.-------- 116 ----------------........----------------------....------.-------- 117 ----------------........----------------------....------.-------- 118 ----------------........----------------------....------.-------- 119 ----------------........----------------------....------.-------- 60 70 80 90 1 | | | | 1 YIRS......TAVLK........NWG..GVDVVVVNDS-IAKEVIRD.CLL..RRGASVEYYER- 2 IVYK......STAFIgallp...DDK..KETLQFVSMSKGNFELAVR.ELLl.VRNYRVEVY--- 3 IVYK......STAFIgallp...DDK..KETLQFVSMSKGNFELAVR.ELLl.VRNYRVEVY--- 4 IVYK......STAFIgallp...DDK..KETLQFVSMSKGNFELAVR.ELLl.VRNYRVEVY--- 5 SVYH......TQSVLknc.....10vtaKNFHEPTKYVTVSLQVLAT.LLKl.CLLDLGYKVEIY 6 SVYH......TQSVLknc.....10vtaKNFHEPTKYVTVSLQVLAT.LLKl.CLLDLGYKVEIY 7 TVYK......TTSVIrqlg....RSD..HTGLPSVTMTVTVFRQFLR.EALf.KLGKRIEIW--- 8 NAYH......TTSVL........KHHn.VSNTSYCNLSPSLFIKFAE.DVLs.NLAKRVEIW--- 9 NAYH......TTSVL........KHHn.VSNTSYCNLSPSLFIKFAE.DVLs.NLAKRVEIW--- 10 EVFK......TQGVIkymg....PAG..AKTLQTVVLSKMNFESFVK.DLLl.VRHYRVEVYKNK 11 EVFK......TQGVIkymg....PAG..SKTLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNK 12 EVFK......TQGVIkymg....PAG..SKTLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNK 13 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 14 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 15 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 16 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 17 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 18 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 19 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 20 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 21 EVFK......TNGVIkyl.....GSG..NKKLESVVLSKMNFESVVK.DLLl.VRQYRVEVYKNK 22 TYYH......TMSALrql.....GSS..SDGILSASVSKAMFETIAR.NILleRTDCTLELYEGS 23 TYYH......TTTALrql.....GSG..SNALSSVSISRNMFETIAR.DLLleRNDHTVELYEGS 24 TYYH......TTTALrql.....GSG..SNALSSVSISRNMFETIAR.DLLleRNDHTVELYEGS 25 NIFKsdvcvkTFTLS........TDN..SQQMKYISVNRGQYEKVVReTIV..LLRCSVELY--- 26 ----......-----........---..-------------------.---..------------ 27 ----......-----........---..-------------------.---..------------ 28 ----......-----........---..-------------------.---..------------ 29 ----......-----........---..-------------------.---..------------ 30 ----......-----........---..-------------------.---..------------ 31 ----......-----........---..-------------------.---..------------ 32 ----......-----........---..-------------------.---..------------ 33 ILHI......KLVPGklt.....10npqDCNHRQFAYCSFPDVRLNV.HLE..RLVHHNLKVAVV 34 ILHI......KLVPGklt.....10npqDCNHRQFAYCSFPDVRLNV.HLE..RLVHHNLKVAVV 35 ELNI......YCHLD........---..-HNFMTASIPTHRLFVHVR.RLV..AKGYKVGVVKQT 36 ELNI......YCHLD........---..-HNFMTASIPTHRLFVHVR.RLV..AKGYKVGVVKQT 37 ELNI......YCHLD........---..-HNFMTASIPTHRLFVHVR.RLV..AKGYKVGVVKQT 38 ELNI......YCHLD........---..-HNFMTASIPTHRLFVHVR.RLV..AKGYKVGVVKQT 39 ELNI......YCHLD........---..-HNFMTASIPTHRLFVHVR.RLV..AKGYKVGVVKQT 40 ELNI......YCHLD........---..-HNFMTASIPTHRLFVHVR.RLV..AKGYKVGVVKQT 41 ELNI......YCHLD........---..-HNFMTASIPTHRLFVHVR.RLV..AKGYKVGVVKQT 42 VLGI......YAHMD........---..-HNFMTASVPTFRLNFHVR.RLV..NAGYKIGVVKQT 43 VLGI......YAHMD........---..-HSFMTASVPTFRLNVHVR.GLV..NAGYKVGVVKQT 44 VLGI......YAHMD........---..-HNFMTA------------.---..--GYKIGVVKQT 45 VLGI......YAHMD........---..-HNFMT-------------.---..-ARYKIGVVKQT 46 VLGI......SCYFE........---..-HNFLNASVPSYRIDYHLE.RLI..NFGLKVAVVRQT 47 VLGI......SCYFE........---..-HNFLNASVPSYRIDYHLE.RLI..NFGLKVAVVRQT 48 ELDI......QYMKG........---..--EQPHCGFPEKNFSVNIE.KLV..RKGYRVLVVEQT 49 ELDI......QYMKG........---..--EQPHCGFPEKNFSVNIE.KLV..RKGYRVLVVEQT 50 ELGF......TYMRG........---..--EFAHSGFPEISFDKMST.ILV..DRGFKVARVEQT 51 ELGL......IFMKG........---..--NWAHSGFPEIAFGRFSD.SLV..QKGYKVARVEQT 52 ELGL......IFMKG........---..--NWAHSGFPEIAFGRFSD.SLV..QKGYKVARVEQT 53 ELGL......VFMKG........---..--NWAHSGFPEIAFGRYSD.SLV..QKGYKVARVEQT 54 ELGL......VFMKG........---..--NWAHSGFPEIAFGRYSD.SLV..QKGYKVARVEQT 55 ELGL......VFMKG........---..--NWAHSGFPEIAFGRYSD.SLV..QKGYKVARVEQT 56 ELGL......VFMKG........---..--NWAHSGFPEIAFGRYSD.SLV..QKGYKVARVEQT 57 ELGL......VFMKG........---..--NWAHSGFPEIAFGRYSD.SLV..QKGYKVARVEQT 58 ALNI......AFMRG........---..--SYAHAGFPEHAASKFAD.QLM..NHGYKVARIEQT 59 VFSL......KLTDR........---..-VNMKMVGIPEASFDYWAS.QFI..AKGYRIARVDQL 60 LFDL......KIAGG........--G..RANMQLAGIPEMSFEYWAA.QFI..QMGYKVAKVDQR 61 LFDL......KIAGG........--G..RANMQLAGIPEMSFEYWAA.QFI..QMGYKVAKVDQR 62 ----......-----........---..-------------------.---..------------ 63 LLNL......RVSKK........KTS..KSDVSMAGFPFFKLDRYLK.ILVe.DLKKCVALSEEV 64 LLNL......RVSKK........KTS..KSDVSMAGFPFFKLDRYLK.ILVe.DLKKCVALSEEV 65 ----......-----........---..-------------------.---..------------ 66 ELNI......SLTNR........AYS..HGKVPFAGFPVHQLSRHLK.MLVn.NCGYSVTIAEQF 67 ELNI......SLTNR........AYS..HGKVPFAGFPVHQLSRHLK.MLVn.NCGYSVTIAEQF 68 ALGL......VLTHK........TSK..DFTTPMAGIPLRAFEAYAE.RLL..KMGFRLAVADQV 69 ALGL......VLTHK........TSK..DFTTPMAGIPLRAFEAYAE.RLL..KMGFRLAVADQV 70 ALGL......VLTHK........TSK..DFTTPMAGIPIRAFDAYAE.RLL..KMGFRLAVADQV 71 ALGL......VLTHK........TSK..DFTTPMAGIPIRAFDAYAE.RLL..KMGFRLAVADQV 72 ALGL......VLTHK........TSK..DFTTPMAGIPIRAFDAYAE.RLL..KMGFRLAVADQV 73 ALGL......VLTHK........TSK..DFTTPMAGIPIRAFDAYAE.RLL..RMGFGLAVADQV 74 ELGL......VLTSRpa......GKG..KERIPMCGVPYHSANSYIA.KLV..NKGYKVAICEQV 75 ELGL......VLTSRpa......GKG..RERIPMCGVPYHSANNYIA.KLV..NKGYKVAICEQV 76 VLNI......VLTRR........---..-QDAPMAGIPYHALNTYLK.KLV..EAGYKVAICDQM 77 VLNI......VLTRR........---..-QDAPMAGIPYHALNTYLK.KLV..EAGYKVAICDQM 78 ----......-----........---..-------------------.---..------------ 79 ELEL......VLTSK........EAGkeVGRVPMAGIPYHALDRYAS.QLV..EKGYAIAICDQV 80 ELEL......ILTSK........EGGkeIGRVAMTGVPHHALDRYAR.QLV..EKGYAVAICDQV 81 ELEL......ILTSK........EGGkeIGRVAMTGVPHHALDRYAR.QLV..EKGYAVAICDQV 82 ILEI......SLTSR........NKNa.DNPIPMAGVPYHSAQQYID.VLI..EQGYKVAIAEQM 83 VLEI......TLTKR........DAKk.ENPIPMCGVPYHSADSYID.TLV..NNGYKVAICEQM 84 ELEI......TLTSR........DGGa.AEKIPMCGVPYHSASAYIE.QLI..KKGYKVAICEQT 85 ELEI......TLTSR........DGGa.AEKIPMCGVPYHSASAYIE.QLI..KKGYKVAICEQT 86 LLDI......TLTQR........GSSg.GAPIPMAGVPVHAYEGYLA.RLI..ALGESVAICEQI 87 LLDI......SLTKR........GASa.GEPIPMAGVPFHAVEGYLA.KLV..QMGESVAICEQI 88 LLDI......SLTKR........GASa.GEPIPMAGIPHHAVENYLA.KLV..NQGESVAICEQI 89 LLDI......SLTKR........GASa.GEPIPMAGIPHHAVENYLA.KLV..NQGESVAICEQI 90 LLDI......SLTKR........GASa.GEPIPMAGIPYHAVENYLA.KLV..NQGESVAICEQI 91 LLDI......SLTKR........GASa.GEPIPMAGIPYHAVENYLA.KLV..NQGESVAICEQI 92 LLDI......SLTKR........SASa.GEPIPMAGIPYHAVENYLA.KLV..NQGESVAICEQI 93 LLDI......SLTKR........GQSa.GQPIPMAGMPYHAVEGYLA.KLV..QLGESVAICEQI 94 LLDI......TLTAR........GQSg.GKAIPMAGIPFHSAEGYLA.KLV..KLGESVAICEQI 95 LLDI......TLTAR........GQSg.GKAIPMAGIPFHSAEGYLA.KLV..KLGESVAICEQI 96 LLDI......TLTAR........GQSa.GKSIPMAGIPFHSVEGYLA.KLV..KLGESVAICEQI 97 LLDI......TLTTRg.......QVD..GEPVKMAGVPFHAAEQYLA.RLV..KLGKSVAICEQV 98 LLDI......TLTTRg.......QVD..GEPVKMAGVPFHAAEQYLA.RLV..KLGKSVAICEQV 99 ALGI......TLTKR........GQHm.GQEIPMCGVPVHAADDYLQ.KLI..ASGYRVAVCEQV 100 ILGI......ALTKR........GKNc.EEEIPMCGVPYHALEHYLT.KLI..EENYKVAICDQL 101 LLGL......TLTKR........---..-NGTPMCGVPVHTARTHIA.RLL..KHGKKVALCEQV 102 NLDI......TLTQR........---..-QNIPMSGIPAAYLDGYVD.RLV..SRGFKIAIAEQA 103 NLDI......TLTQR........---..-QNVPMSGIPATCLDGYVD.RLV..SRGFKVAIAEQA 104 HLEL......TLTQR........---..-QGIPMSGIPVSTVDTYVD.RLI..GKGFKVAVAEQF 105 HLEL......TLTQR........---..-QGIPMSGIPVSTVDTYVD.RLI..GKGFKVAVAEQF 106 LLNL......TLTKR........---..-ENVPMCGVPYHTSKEYIR.KLI..LFDKKVAICEQA 107 ELDW......KMTMS........GV-..-GKCRQVGISESGIDEAVQ.KLL..ARGYKVGRIEQL 108 ELDW......KMTMS........GV-..-GKCRQVGISESGIDEAVQ.KLL..ARGYKVGRIEQL 109 ELDW......KMTVS........GV-..-GKCRQVGISESGIDDAVD.KLI..ARGYKVGRIEQM 110 ELDW......KMTVS........GV-..-GKCRQVGISESGIDDAVD.KLI..ARGYKVGRIEQM 111 LLDM......KIISL........--G..KRSLLQMGFPVYSLTTHLS.TLL..DKGWTVIVIDEL 112 ----......-----........---..-------------------.---..------------ 113 ----......-----........---..-------------------.---..------------ 114 ----......-----........---..-------------------.---..------------ 115 ----......-----........-GP..RSGIPSASFPSPQP-----.---..------------ 116 ----......-----........-GP..RSGIPSASFPSPQP-----.---..------------ 117 ----......-----........---..-------------------.---..------------ 118 ----......-----........---..-------------------.---..------------ 119 ----......-----........---..-------------------.---..------------ 00 110 120 130 | | | | 1 ---...--PP........GGGTYACVQRGSPGNITDf...EATL...Fsfe.....22nnkGGNA 2 ---...--VK........NSSDWEIEYRGSPGNLLQf...EDIL...F........SNKEVLVGN 3 ---...--VK........NSSDWEIEYRGSPGNLLQf...EDIL...F........SNKEVLVGN 4 ---...--VK........NSSDWEIEYRGSPGNLLQf...EDIL...F........SNKEVLVGN 5 DK-...----........------GWKLIKSASPGN....IEQv...N........ELMnmnIDS 6 DK-...----........------GWKLIKSASPGN....IEQv...N........ELMnmnIDS 7 ---...ASPS........GRMNWKVVKQASPGNLQDv...EDELggqF........EGAPVILAV 8 ---...GANS........AKTGFELLKQASPGNMQMl...EDLL...Vsen.....13sdsSVSS 9 ---...GANS........AKTGFELLKQASPGNMQMl...EDLL...Vsen.....13sdsSVSS 10 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMATSI 11 AG-...NKAS........KENEWYLAFKASPGNLSQf...EDIL...F........GNNDMSASV 12 AG-...NKAS........KENEWYLAFKASPGNLSQf...EDIL...F........GNNDMSASV 13 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 14 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 15 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 16 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 17 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 18 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 19 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 20 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 21 SG-...GKYS........KENDWQLAFKASPGNLTQf...EEIL...F........GNNDMSTAV 22 GS-...----........---NWRLTKSGTPGNIGSf...EDIL...Fanndm...EDSPVIVAL 23 GS-...----........---NWRLVKTGSPGNIGSf...EDVL...Fannem...QDTPVVVSI 24 GS-...----........---NWRLVKTGSPGNIGSf...EDVL...Fannem...QDTPVVVSI 25 ---...--SS........EQGEWKMTKRGSPGNTVDfe..QEIG...V........SDQAPILAI 26 ---...----........------------------....----...-fdf.....DEEIVMCID 27 ---...----........------------------....----...-stifsfdfDEEIVMCID 28 ---...----........------------------....----...-........NSDVVIVV- 29 ---...----........------------------....-AIS...A........HSPSVIVAV 30 ---...----........------------------....-AIS...A........HSPSVIVAV 31 ---...----........------------------....--LLg..P........SIDCVLCCI 32 ---...----........------------------....--LLg..P........SIDCVLCCI 33 EQA...ETSA........IKKhdpgasksSVFERKI....SNVF...T........KATFGVNST 34 EQA...ETSA........IKKhdpgasksSVFERKI....SNVF...T........KATFGVNST 35 ETA...ALKAigdnrs..SLFSRKLTALYTKSTLIG....EDVN...Plik.....16mtdTSTS 36 ETA...ALKAigdnrs..SLFSRKLTALYTKSTLIG....EDVN...Plik.....16mtdTSTS 37 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG....EDVN...Plir.....16mtdTSTN 38 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG....EDVN...Plir.....16mtdTSTN 39 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG....EDVN...Plir.....16mtdTSTN 40 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG....EDVN...Plir.....16mtdTSTN 41 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG....EDVN...Plir.....16mtdTSTN 42 ETA...AIKShganrt..GPFFRGLSALYTKATLEAa...EDIS...Ggcg.....9egfgSQSN 43 ETA...AIKShganra..GPFFRGLSGLYTKATLEAa...EDIS...Ggcv.....9egfgGQSN 44 ETA...AIKShganrt..GPFFRGLSALYTKATLEAa...EDIS...Ggcg.....9egfgSQSN 45 ETA...AIKShganrt..GPFFRGLSALYTKATLEAa...EDIS...Ggcg.....9egfgSQSN 46 ETA...ALKStsssrn..TLFDRRVARVLTKGTTLD....DSFFr..-feq.....9hgtlQASQ 47 ETA...ALKStsssrn..TLFDRRVARVLTKGTTLD....DSFFr..-feq.....9hgtlQASQ 48 ETP...DQLEqrr.....10skdKVVKREVCAVVTK....GTLT...D........GEMLltNPD 49 ETP...DQLEqrr.....10skdKVVKREVCAVVTK....GTLT...D........GEMLltNPD 50 ETP...DMMTerc.....12kfdKVVAREICQITNR....GTQV...F........GSQCkig-p 51 ETP...EMMEarc.....13kfdRVVRREICRIITK....GTQT...Ysvld....GDPSENYSR 52 ETP...EMMEarc.....13kfdRVVRREICRIITK....GTQT...Ysvld....GDPSENYSR 53 ETP...EMMEarc.....13kydRVVRREICRIITK....GTQT...Ysvle....GDPSENYSK 54 ETP...EMMEarc.....13kydRVVRREICRIITK....GTQT...Ysvle....GDPSENYSK 55 ETP...EMMEarc.....13kydRVVRREICRIITK....GTQT...Ysvle....GDPSENYSK 56 ETP...EMMEarc.....13kydRVVRREICRIITK....GTQT...Ysvle....GDPSENYSK 57 ETP...EMMEarc.....13kydRVVRREICRIITK....GTQT...Ysvle....GDPSENYSK 58 ETP...QMLEern.....10tkeKVVRREVCRVTSN....GTRT...Y........GVLDGvdl1 59 ETA...LGKEikd.....11keeKVVQRGLTQVLTS....GTLV...D........EAMLtSDLS 60 ESM...LAKEmregsk..GIVKRELQCILTSGTLTD....GDMLh..S........DLATFCLAI 61 ESM...LAKEmregsk..GIVKRELQCILTSGTLTD....GDMLh..S........DLATFCLAI 62 ---...----........------------------....----...-........--------- 63 IRPvddLSSK........NMYIRSVTRVITPGTLID....ENFMn..P........YESNYILTV 64 IRPvddLSSK........NMYIRSVTRVITPGTLID....ENFMn..P........YESNYILTV 65 ---...----........------VTRVITPGTLID....ENFMn..P........YESNYILTV 66 KKK...DVADnea.....NKFYRRVTRIVTPGTFID....EAFEn..L........RENTYLLNI 67 KKK...DVADnea.....NKFYRRVTRIVTPGTFID....EAFEn..L........RENTYLLNI 68 EPA...EEAE........GLVRREVTQLLTPGTLLQ....ESLL...P........REANYLAAI 69 EPA...EEAE........GLVRREVTQLLTPGTLLQ....ESLL...P........REANYLAAI 70 EPA...EEAE........GLVRREVTQLLTPGTLTQ....EALL...P........REANYLAAI 71 EPA...EEAE........GLVRREVTQLLTPGTLTQ....EALL...P........REANYLAAI 72 EPA...EEAE........GLVRREVTQLLTPGTLTQ....EALL...P........REANYLAAI 73 EPA...EEAE........GLVRREVTQLLTPGTLTQ....EALL...P........REANYLAAI 74 EDP...SKAK........GIVKREVVRVITPGTFFE....----...-........RDTGGLASL 75 EDP...SKAK........GIVKRDVIRVITPGTFFE....----...-........RETGGLCSL 76 EEP...SKSK........KLIRREVTRVVTPGSIVE....DEFL...S........ETNNYMAVV 77 EEP...SKSK........KLIRREVTRVVTPGSIVE....DEFL...S........ETNNYMAVV 78 ---...----........------------------....----...-........--------- 79 ETA...AQAQg.......PLVRREITRIITPGTILE....EGMLq..A........RRNNFLAAV 80 EDA...AEAQaek.....RMVERQVTKLLTPGTLTD....DSMLp..A........KRNNFLAAI 81 EDA...AEAQaek.....RMVERQVTKLLTPGTLTD....DSMLp..A........KRNNFLAAI 82 EDP...KQAV........GVVKREVVQVITPGTVVD....SSKP...D........SQNNFLVSI 83 EDP...KQTK........GMVRREVVRIVTPGTVMEq...GGVD...D........KQNNYILSF 84 EDP...KAAK........GVVKREVVQLITPGTVMD....GKGIh..E........SENNFIASV 85 EDP...KAAK........GVVKREVVQLITPGTVMD....GKGIh..E........SENNFIASV 86 GDP...GLAK........GLVERKVVRIVTPGTITD....EVLLe..E........RRDTLLMAL 87 GDP...ATSK........GPVERKVVRIVTPGTVTD....EALLs..E........RVDNLIAAI 88 GDP...ATSK........GPVERKVVRIVTPGTISD....EALLq..E........RQDNLLAAI 89 GDP...ATSK........GPVERKVVRIVTPGTISD....EALLq..E........RQDNLLAAI 90 GDP...ATSK........GPVERKVVRIVTPGTISD....EALLq..E........RQDNLLAAI 91 GDP...ATSK........GPVERKVVRIVTPGTISD....EALLq..E........RQDNLLAAI 92 GDP...ATSK........GPVERKVVRIVTPGTISD....EALLq..E........RQDNLLAAI 93 GDP...TTSK........GPVERQIVRIVTPGTVSD....EALLp..E........RQDNLIAAV 94 GDP...ATSK........GPVERQVVRIITPGTVSD....EALLd..E........RRDNLLAAI 95 GDP...ATSK........GPVERQVVRIITPGTVSD....EALLd..E........RRDNLLAAI 96 GDP...ATTK........GPVERQVVRIITPGTVSD....EALLd..E........RRDNLLAAV 97 GEV...GAGK........GPVERKVVRIVTPGTLTD....SALLe..D........KETNRIVAV 98 GEV...GAGK........GPVERKVVRIVTPGTLTD....SALLe..D........KETNRIVAV 99 EDP...AEAKkrgsk...SVVRRDVVRLVTPGTITE....DKLLs..P........SESNYLMAL 100 ETP...EEAKkrdgyk..AVVTRDVTRIITPGTIIE....ENLIs..V........TEPNYLTSL 101 SHP...-VPG........ELTQRKVIEIISPGTAVE....DDFLs..Q........GFSQYLATV 102 DNS...EGGK........GLVPRTINRLITPGALLS....SSLLp..E........KANNYIIAI 103 DNT...EGSK........GLVPRTINRLITPGALLS....SSLLp..E........KANNYVLAI 104 GEP...AKEKeskki...GPMARDIQRFVTPGTLLS....STLLq..E........KFNNYIVAI 105 GEP...AKEKeskki...GPMARDIQRFVTPGTLLS....STLLq..E........KFNNYIVAI 106 SN-...STSG........GPLEREVVEVITPGVIID....EDFLn..D........DINNYLVAI 107 ETS...DQAKargan...TIIPRKLVQVLTPSTASE....GNIG...P........-DAVHLLAI 108 ETS...DQAKargan...TIIPRKLVQVLTPSTASE....GNIG...P........-DAVHLLAI 109 ESA...NQAKargvh...SVIERKLVHVSTPSTAVDni..----...G........TDAVHLLAL 110 ESA...NQAKargvh...SVIERKLVHVSTPSTAVDni..----...G........TDAVHLLAL 111 VTN...--KS........GPKQRAVSQVYSPSCNLE....DCPEl..-........---PYVLSI 112 ---...----........------------------....--EQ...F........RDETVLSLS 113 ---...----........------------------....--EQ...F........RDETVLSLS 114 ---...----........------------------....--EQ...F........RDETVLSLS 115 ---...----........--------PMAGPGGIEE....EDEE...E........PAEIHLCVL 116 ---...----........--------PMAGPGGIEE....EDEE...E........PAEIHLCVL 117 ---...----........------------------....----...-eee.....LAEIHLCVL 118 ---...----........------------------....----...-eee.....LAEIHLCVL 119 ---...----........------------------....----...-eee.....LAEIHLCVL 140 150 160 170 1 | | | | 1 G........KCMI........Sg-GQGirVGFAALNTTLRT........LTYAEYLDtlqLTSLD 2 Siis.....11dgg.......GQRRVGVASVEQNDCKFQLL........EFLDddfFTELEATVV 3 Siis.....11dgg.......GQRRVGVASVEQNDCKFQLL........EFLDddfFTELEATVV 4 Siis.....11dgg.......GQRRVGVASVEQNDCKFQLL........EFLDddfFTELEATVV 5 S........IIIA........SLKvqwnsqdGNCIIGVAFI........DTTAYKVGMLDIVDne 6 S........IIIA........SLKvqwnsqdGNCIIGVAFI........DTTAYKVGMLDIVDne 7 Kisakas..EART........VGVCFADASVRELGVSEFLDndl.....YSNFEALLIQLGVKEC 8 V........LLAV........TtrvkqDQRIIGVAFIDPIL........KKLGVSEFVDsdaYTN 9 V........LLAV........TtrvkqDQRIIGVAFIDPIL........KKLGVSEFVDsdaYTN 10 Gimg.....10tvd.......GQRQVGVGDVDSTQRKLGLC........EFPDndqFSNLEALLI 11 Gvmg.....10vvd.......GQRHVGVGYVDSTQRKLGLC........EFPEndqFSNLEALLI 12 Gvmg.....10vvd.......GQRHVGVGYVDSTQRKLGLC........EFPEndqFSNLEALLI 13 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 14 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 15 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 16 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 17 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 18 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 19 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 20 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 21 Gvvg.....10sse.......GQRLVGVGYVDSTLRKLGVC........EFPDndqFSNLEALLV 22 Fpacre...SQLY........VGLSFLDMTNRKLGLAEFPEdsr.....FTNVESALVALGCKEC 23 Fpsfhd...GRCV........IGMAYVDLTRRVLGLAEFLDdsr.....FTNLESSLIALGAKEC 24 Fpsfhd...GRCV........IGMAYVDLTRRVLGLAEFLDdsr.....FTNLESSLIALGAKEC 25 Yihpgd...DDNR........VTLCAWDAGNVRIVISEYIDtps.....FSQTEQCIFGLCPTEY 26 F........SGGK........LGCSILDYHTKTLKAFDQDYvvn.....23ndiSLLLGLLIMEA 27 -f.......SGGK........LGCSILDYHTKTLKAFDQDYvvnk....--------TTISSHDL 28 -megrgs..CEGH........IGIALHDTCFPEIHLCEFVDsre.....YTTLKTMINVHEAFDI 29 V........EGRGlarge...IGMASIDLKNPQIILSQFADntt.....YAKVITKLKILSPLEI 30 V........EGRGlarge...IGMASIDLKNPQIILSQFADntt.....YAKVITKLKILSPLEI 31 Yevprd...ISTR........IGLCIINCNTGQMYLSDFMDsqi.....YIRVVHKLQIYQPTEI 32 Yevprd...ISTR........IGLCIINCNTGQMYLSDFMDsqi.....YIRVVHKLQIYQPTEI 33 F........Vlrgkril....GDTNSIWALSrdvhQGK-vak.......YSLISVNLNNGEVVYD 34 F........Vlrgkril....GDTNSIWALSrdvhQGK-vak.......YSLISVNLNNGEVVYD 35 Y........LLCI........Senk11kkk----gnifIGI........VGVQPATGEVVFDSFQ 36 Y........LLCI........Senk11kkk----gnifIGI........VGVQPATGEVVFDSFQ 37 Y........LLCI........Yeek11kkkGNLSVGVVGVQ........PATGEVVFDCFQDsas 38 Y........LLCI........Yeek11kkkGNLSVGVVGVQ........PATGEVVFDCFQDsas 39 Y........LLCI........Yeek11kkkGNLSVGVVGVQ........PATGEVVFDCFQDsas 40 Y........LLCI........Yeek11kkkGNLSVGVVGVQ........PATGEVVFDCFQDsas 41 Y........LLCI........Yeek11kkkGNLSVGVVGVQ........PATGEVVFDCFQDsas 42 F........LVCV........VDERVkse16dvrVGVVGVE........ISTGEVVYEEFNDnfm 43 F........LVCV........VDERVdre17dvrVGVVGVE........ISTGEVVHGEFNDnfm 44 F........LVCV........VDERVkse16dvrVGVVGVE........ISTGEVVYEEFNDnfm 45 F........LVCV........VDERVkse16dvrVGVVGVE........ISTGEVVYEEFNDnfm 46 F........ILCV........Adnv9skakSGR-vqVGLIA........IQLSSGTTVYDHFQDd 47 F........ILCV........Adnv9skakSGR-vqVGLIA........IQLSSGTTVYDHFQDd 48 A........SYLM........ALTeggesl----tnptaehn.......FGVCLVDVATQKIILG 49 A........SYLM........ALTeggesl----tnptaehn.......FGVCLVDVATQKIILG 50 n........HQPN........YMLAIVekdegTCSRYGVCF........IDTSIGDFHLGEFEDd 51 Y........LLSL........KekeeetsgHTRVYGVCFVD........TSLGKFFIGQFSDdrh 52 Y........LLSL........KekeeetsgHTRVYGVCFVD........TSLGKFFIGQFSDdrh 53 Y........LLSL........KekeedssgHTRAYGVCFVD........TSLGKFFIGQFSDdrh 54 Y........LLSL........KekeedssgHTRAYGVCFVD........TSLGKFFIGQFSDdrh 55 Y........LLSL........KekeedssgHTRAYGVCFVD........TSLGKFFIGQFSDdrh 56 Y........LLSL........KekeedssgHTRAYGVCFVD........TSLGKFFIGQFSDdrh 57 Y........LLSL........KekeedssgHTRAYGVCFVD........TSLGKFFIGQFSDdrh 58 1tld.....PTAK........HLLAIKefhnpetGKSSYGV........CMIDTTTAHIRIGQFE 59 T........YCMA........IKeslqsdnEEPSFGICFID........TSTGGFHMCEFTDdih 60 Reep.....21qkl.......NTKIFGAAFIDTATGELQML........EFEDdseCTKLDTLMS 61 Reep.....21qkl.......NTKIFGAAFIDTATGELQML........EFEDdseCTKLDTLMS 62 -........----........--------------------........---------------- 63 V........----........--------------------........---------------- 64 Vfdp.....22dcf.......ADCKIGLSWLDLSTGEFFTQ........DSN-LQRLAGDLTRIS 65 Vfdp.....22dcf.......ADCKIGLSWLDLSTGEFFTQ........DSN-LQRLAGDLTRIS 66 Efpe.....11vad.......TSLKVGICWCDVSTGEIFVQ........QVY-LRDLVSAITRIQ 67 Efpe.....11vad.......TSLKVGICWCDVSTGEIFVQ........QVY-LRDLVSAITRIQ 68 A........TGDG........WGLAFLDVSTGEFKGTVLKS........KSALYDELFRHRPAEV 69 A........TGDG........WGLAFLDVSTGEFKGTVLKS........KSALYDELFRHRPAEV 70 A........TGDG........WGLAFLDVSTGEFKGTLLKS........KSALYDELFRHRPAEV 71 A........TGDG........WGLAFLDVSTGEFKGTLLKS........KSALYDELFRHRPAEV 72 A........TGDG........WGLAFLDVSTGEFKGTLLKS........KSALYDELFRHRPAEV 73 A........TGDG........WGLAFLDVSTGEFKATLLKS........KSALYDELFRHRPAEV 74 Yk.......KGNH........YYVGYLNLAVGEFLGAKVK-........IEELLDLLSKLNIKEI 75 Yr.......KGKS........YLVSYLNLSVGEFIGAKVK-........EEELIDFLSKFNIREV 76 Se.......EKGR........YCTVFCDVSTGEVLVHESSD........EQETLDLLKNYSISQI 77 Se.......EKGR........YCTVFCDVSTGEVLVHESSD........EQETLDLLKNYSISQI 78 -........----........--------------------........---------------- 79 Vi.......AGEH........WGLAYADSSTGDYWTSQSTG........LEGL------------ 80 Am.......VEDK........WGLAHADISTGEFFTCQSSN........LDDLAVELLRLQPSEV 81 Am.......VEDK........WGLAHADISTGEFFTCQSSN........LDDLAVELLRLQPSEV 82 Dr.......EGNQ........FGLAYMDLVTGDFYVTGLLD........FTLVCGEIRNLKAREV 83 Vm.......NQPE........IALSYCDVSTGELKVTHFND........EATLLNEITTINPNEV 84 Sa.......CSNG........YGLALSDLTTGENLAVLIER........LEDVISEIYSVGAREI 85 Sa.......CSNG........YGLALSDLTTGENLAVLIER........LEDVISEIYSVGAREI 86 Sr.......SKNC........YGLAWADLAGGRFLVNEVNS........EEALEAELARLEPAEL 87 Yh.......HNGR........FGYATMDITSGRFQLSEPQT........EEEMAAELQRTSPREL 88 Wq.......DGKG........YGYATLDISSGRFRLSEPAD........RETMAAELQRTNPAEL 89 Wq.......DGKG........YGYATLDISSGRFRLSEPAD........RETMAAELQRTNPAEL 90 Wq.......DSKG........FGYATLDISSGRFRLSEPAD........RETMAAELQRTNPAEL 91 Wq.......DSKG........FGYATLDISSGRFRLSEPAD........RETMAAELQRTNPAEL 92 Wq.......DSKG........FAYATLDISSGRFRLSEPAD........RETMAAELQRTNPAEL 93 Yq.......EKEK........FGLATLDMTSGRFQLCEPAD........KETLRAELQRIAPVEL 94 Lg.......DERL........FGLAVLDITSGRFSVQEIKG........WETLLAELERLNPAEL 95 Lg.......DERL........FGLAVLDITSGRFSVQEIKG........WETLLAELERLNPAEL 96 Vg.......DERL........FGLAILDITSGRFNVQEIQG........WENLLAELERLNPAEL 97 Sp.......DKKY........IGLAWASLQSGEFKTKLTT-........VDKLDDELARLQAAEI 98 Sp.......DKKY........IGLAWASLQSGEFKTKLTT-........VDKLDDELARLQAAEI 99 Arirsg...SEPA........YALAWIDISTGIFRLAETA-........ESRLLADILRIEPREL 100 Vipk.....NKKT........ASICCVDLSTSKIFVINVP-........ETEILNELARLKSREI 101 Ca.......SDAT........VAFSYLEVSTGAFFITSFPRaea.....ADALQKEFGRVQPSEV 102 Sq.......VGSL........YGLSCLDLSTGTFLVAEYDN........TKDLIEAVYRLAPTEL 103 Nq.......VGSL........YGLSCLDLSIGTFLVAEYDN........TKDLIEAICRLAPTEL 104 Nr.......IGSL........FGFACLDLSTGSFFIEECEN........TKELVDEICRLAPSEV 105 Nr.......IGSL........FGFACLDLSTGSFFIEECEN........TKELVDEICRLAPSEV 106 Sd.......YKDY........YSFSYIDLSTSSLGIMFYENgf......FEKLKRDLEKYSPKEI 107 KeikmelqkCSTV........YGFAFVDCAALRFWVGSISDdas.....CAALGALLMQVSPKEV 108 KeikmelqkCSTV........YGFAFVDCAALRFWVGSISDdas.....CAALGALLMQVSPKEV 109 Kevtlass.GFQV........FGFAFLDYAALKIWVGSVQDdds.....SAALGALLMQVSPREL 110 Kevtlass.GFQV........FGFAFLDYAALKIWVGSVQDdds.....SAALGALLMQVSPREL 111 Yfs......QDDL........LGITLFSAMNGHSIIFPVSWtd......RDKVTRLLISYHIREI 112 F........AQGM........LGAAYYEQSSQLLKIMNDISedle....FRFLKRLIDDVKPTLI 113 F........AQGM........LGAAYYEQSSQLLKIMNDISedle....FRFLKRLIDDVKPTLI 114 F........AQGM........LGAAYYEQSSQLLKIMNDISedle....FRFLKRLIDDVKPTLI 115 W........SSGY........LGIAYYDTSDSTIHFMPDAPdhes....LKLLQRVLDEINPQSV 116 W........SSGY........LGIAYYDTSDSTIHFMPDAPdhes....LKLLQRVLDEINPQSV 117 W........NSGY........LGIAYYDTSDSTIHFMPDAPdhes....LKLLQRVLDEINPQSV 118 W........NSGY........LGIAYYDTSDSTIHFMPDAPdhes....LKLLQRVLDEINPQSV 119 W........NSGY........LGIAYYDTSDSTIHFMPDAPdhes....LKLLQRVLDEINPQSV 80 190 200 210 2 | | | | 1 AL.....MAQCNL........K....ELIYlDKSRCRGGSNSDR........GGGAAGVCRRKRa 2 LL.....GPKECL........L....P-SIEGEYSAVKTLLDRN........GVMITMPkks25q 3 LL.....GPKECL........L....P-SIEGEYSAVKTLLDRN........GVMITMPkks25q 4 LL.....GPKECL........L....P-SIEGEYSAVKTLLDRN........GVMITMPkks25q 5 vY.....SNLESF........L....IQLGVKECLVqdltsNSN........SNAEMQKVINVID 6 vY.....SNLESF........L....IQLGVKECLVqdltsNSN........SNAEMQKVINVID 7 IVtqdkgEKEKDP........E....LAKLRQIIDNCGVAIAERsag.....23eraASLLPQTD 8 FE.....ALIVQV........G....AKECIISQSGHEstn13nta......EINRLRNIIEGCG 9 FE.....ALIVQV........G....AKECIISQSGHEstn13nta......EINRLRNIIEGCG 10 QI.....GPKECI........L....PGGETAGdMGKLRQVIQR........GGILITERkri27 11 QI.....GPKECV........L....PGGETTGdMGKLRQVIQR........GGILITERkra27 12 QI.....GPKECV........L....PGGETTGdMGKLRQVIQR........GGILITERkra27 13 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 14 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 15 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 16 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 17 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 18 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 19 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 20 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 21 QI.....GPKECV........M....PGGETAGdMGKLRQIVKR........GGILITDRkra27 22 LL.....PADCEK........Sid..LNPLQDVISNCNVLLTEKkka.....23svePVRDLLSQ 23 IFpa...ESGKSN........E....CKSLYDSLERCAVMITERkkh.....23niePVRDLVSG 24 IFpa...ESGKSN........E....CKSLYDSLERCAVMITERkkh.....23niePVRDLVSG 25 ILvn...EGSVAP........K....AKKIASMFTRMEVHNKQQlkp.....13iesVHLDYKDE 26 NP.....TVCLVP........A....RLEDWi------------........------fdy77nd 27 ID.....DADMSS........N....DISLLLGLLIMEANPTVClvp.....87ndsTASSNMVT 28 VI.....QNGNEE........R....GSTKLLGEALMTAFPEASlqs.....27evsTVSEGCLR 29 IM.....SNTACA........V....GNSTKLFTLITENFKNVNftt.....27efsTVLMEVQS 30 IM.....SNTACA........V....GNSTKLFTLITENFKNVNftt.....27efsTVLMEVQS 31 LI.....PSSSLA........P....TVSKLATMIKFNVAETVKiee.....29kkdLKIEEIID 32 LI.....PSSSLA........P....TVSKLATMIKFNVAETVKiee.....29kkdLKIEEIID 33 EF.....EEpnla........D....EKLQIRIKYLQPIEVLVN........TDDLPLHVAKFFK 34 EF.....EEpnla........D....EKLQIRIKYLQPIEVLVN........TDDLPLHVAKFFK 35 Dsas...RSELET........R....MSSLQPVELLLPSALSEQ........TEALIHRATSVSV 36 Dsas...RSELET........R....MSSLQPVELLLPSALSEQ........TEALIHRATSVSV 37 RL.....ELETRI........S....SLQPVELLLPSDLSEPTE........MLIQRATNVSVRD 38 RL.....ELETRI........S....SLQPVELLLPSDLSEPTE........MLIQRATNVSVRD 39 RL.....ELETRI........S....SLQPVELLLPSDLSEPTE........MLIQRATNVSVRD 40 RL.....ELETRI........S....SLQPVELLLPSDLSEPTE........MLIQRATNVRLKT 41 RL.....ELETRI........S....SLQPVELLLPSDLSEPTE........MLIQRATNVRLKT 42 RS.....GLEAVI........L....SLSPAELLLGQPLSQQTE........KFLVAHAGPTSNV 43 RS.....GLEAVI........L....------------------........------------- 44 RS.....GLEAVI........L....SLSPAELLLGQPLSQQTE........KFLVAHAGPTSNV 45 RS.....GLEAVI........L....SLSPAELLLGQPLSQQTE........KFLVAHAGPTSNV 46 fl.....RSELQT........R....LSHFQPCELIYSNKLSSE........SVALLNHYVSTEK 47 fl.....RSELQT........R....LSHFQPCELIYSNKLSSE........SVALLNHYVSTEK 48 QF.....KDdqdC........S....ALSCLLSEMRPVEIIKPA........KVLSYaTERTIVR 49 QF.....KDdqdC........S....ALSCLLSEMRPVEIIKPA........KVLSYaTERTIVR 50 kn.....CSRLLT........L....VSHHMPVLFLNEKSALSQ........RTQQIVRTVLGGI 51 CS.....RFRTLV........A....HYPPVQILFEKGNLSTeT........KTVLKGSLSSCLQ 52 CS.....RFRTLV........A....HYPPVQILFEKGNLSTeT........KTVLKGSLSSCLQ 53 CS.....RFRTLV........A....HYPPVQVLFEKGNLSKeT........KTILKSSLSCSLQ 54 CS.....RFRTLV........A....HYPPVQVLFEKGNLSKeT........KTILKSSLSCSLQ 55 CS.....RFRTLV........A....HYPPVQVLFEKGNLSKeT........KTILKSSLSCSLQ 56 CS.....RFRTLV........A....HYPPVQVLFEKGNLSKeT........KTILKSSLSCSLQ 57 CS.....RFRTLV........A....HYPPVQVLFEKGNLSKeT........KTILKSSLSCSLQ 58 Dddy...RSQLRT........L....LANVIVVQAIVERGSISS........TTKSIINGILFSV 59 RT.....KLDTLL........T....QVRPKELILEKSKISQks........IRAIKYCVSSSSI 60 QV.....RPMEVV........M....ERNNLSTLANKIVKFNSA........PNAIFNEvka32p 61 QV.....RPMEVV........M....ERNNLSTLANKIVKFNSA........PNAIFNEvka32p 62 --.....------........-....------------------........------------- 63 --.....------........-....------------------........------------- 64 PR.....EIVLDE........S....LKSFtTHPIYSFIQERKY........FLSYVenr18kei 65 PR.....EIVLDE........S....LKSFtTHPIYSFIQERKY........FLSYVenr18kei 66 PK.....EILLDE........R....LLEfhi10wypELVELKK........FFIKYQKMPSQHr 67 PK.....EILLDE........R....LLEfhi10wypELVELKK........FFIKYQKMPSQHr 68 LL.....APELLE........N....GAFLDEFRKRFPVMLSEA........PFEPEGEGPLALR 69 LL.....APELLE........N....GAFLDEFRKRFPVMLSEA........PFEPEGEGPLALR 70 LL.....APELRE........N....EAFVAEFRKRFPVMLSEA........PFEPQGEGPLALR 71 LL.....APELRE........N....EAFVAEFRKRFPVMLSEA........PFEPQGEGPLALR 72 LL.....APELRE........N....EAFVAEFRKRFPVMLSEA........PFEPQGEGPLALR 73 LL.....APELRE........N....EAFVAQFRKRFPVMLSEA........PFDPEGEAPLALS 74 LVkk...GEKLPE........E....LEKVLKVYVSELEEEFFEegs.....13gvlSLQAFGFE 75 LVkk...GEKLPE........K....LEKVLKLHITELEEEFFEegk.....13gvpSIKAFGFQ 76 IC.....PEHLKS........S....LKERFPGVYTETISEWYFsdl.....12ynlKDIHHFEL 77 IC.....PEHLKS........S....LKERFPGVYTETISEWYFsdl.....12ynlKDIHHFEL 78 --.....------........-....------------------........------------- 79 --.....------........-....------------------........------------- 80 LI.....PTSAPD........I....RNILRPGEPSEHIPKQLPtsf.....30vksLEGMGCEG 81 LI.....PTSAPD........I....RNILRPGEPSEHIPKQLPtsf.....30vksLEGMGCEG 82 VL.....GYDLSE........EeeqiLSRQMNLVLSYEKESFED........LHLLDLRLATVEQ 83 VI.....NDNISD........N....LKRQINMVTETITVRETLsse.....IYSVNQTEHKLMY 84 VV.....SGSLDA........D....TVAQLRERCGATISIEDGetdeh...VTIIEHLNNEDIT 85 VV.....SGSLDA........D....TVAQLRERCGATISIEDGetdeh...VTIIEHLNNEDIT 86 LLp....DEDAWP........E....YLQQRNGVRRRPPWLFDAdsg.....15lhdLSGFGIEN 87 LF.....PEDFSP........Vh...LMASRQGNRRRPIWEFELdta.....15trdLVGFGVEQ 88 LY.....AEDFAE........Ma...LIEGRRGLRRRPLWEFEIdta.....15trdLVGFGVEN 89 LY.....AEDFAE........Ma...LIEGRRGLRRRPLWEFEIdta.....15trdLVGFGVEN 90 LY.....AEDFAE........Ms...LIEGRRGLRRRPLWEFEIdta.....15trdLVGFGVEN 91 LY.....AEDFAE........Ms...LIEGRRGLRRRPLWEFEIdta.....15trdLVGFGVEN 92 LY.....AEDFAE........Ms...LIEGRRGLRRRPLWEFEIdta.....15trdLVGFGVEN 93 LY.....CEEFNE........Ma...AIEHCKGLRRRPIWEFELsta.....15tkdLRAFGVEK 94 LI.....PDDWPQ........Gl...PAEKRRGVRRRAPWDFDRdsa.....15tqdLKGFGCQN 95 LI.....PDDWPQ........Gl...PAEKRRGVRRRAPWDFDRdsa.....15tqdLKGFGCQN 96 LY.....PDDWPA........Gl...PLEKRRGAHRRAPWDFDFdsa.....15tqdLKGFGCDG 97 LL.....PDSKNA........P....QLQTASGVTRLNAWQFAAdag.....17dlrGFGLDGKE 98 LL.....PDSKNA........P....QLQTASGVTRLNAWQFAAdag.....17dlrGFGLDGKE 99 IL.....PDTVFH........D....PDLRPVFDVLGRVAVPQPavl.....20gvgTLDGFGSF 100 LL.....SENLKS........Sn...ISDSILKQFNCRITYQVDsff.....19kirDIKGIGEI 101 LL.....SASVLR........S....LPELAAILSLYPRLVRTTgad.....23trnLDCLTLLP 102 LS.....HAKFYQ........Kn...EPVVKQLQQHLRITLSEHvsw.....22vssLDGFGLQG 103 LS.....HAKFYQ........Kn...EAVIKQLQQHLRITLSEYvsw.....22vssLDGFGLQG 104 LS.....CNKFYN........Ke...TAIVMQLQQHLKLTLSTYadw.....22vasLDGFGLKG 105 LS.....CNKFYN........Ke...TAIVMQLQQHLKLTLSTYadw.....22vasLDGFGLKG 106 IV.....SENFYY........EysekLNLSRFLINRVPTWHLDKdia.....15ilgLSSLGFDE 107 LYd....SKGLSR........E....AQKALRKYTLTGSTAVQLapv.....33swnCAVDGLNE 108 LYd....SKGLSR........E....AQKALRKYTLTGSTAVQLapv.....33swnCAVDGLNE 109 IY.....ETSGIS........Ke...TQRTIRKYASAGSVKMQLtpl.....32swlSALDCTMN 110 IY.....ETSGIS........Ke...TQRTIRKYASAGSVKMQLtpl.....32swlSALDCTMN 111 VIwa...DSGVCS........Nil..INKIYNLLIGWNLFPSEPnak.....56kifQSTWTENV 112 IA.....NRSQDL........E....FIKFLTTRYDPQEKIYEDgtt.....84yiiIKMRFDIE 113 IA.....NRSQDL........E....FIKFLTTRYDPQEKIYEDgtt.....84yiiIKMRFDIE 114 IA.....NRSQDL........E....FIKFLTTRYDPQEKIYEDgtt.....84yiiIKMRFDIE 115 VT.....SAKQDE........A....MTRFLGKLASEEHREPKGpei.....40ilfLSSIIPFD 116 VT.....SAKQDE........A....MTRFLGKLASEEHREPKGpei.....40ilfLSSIIPFD 117 VT.....SAKQDE........N....MTRFLGKLASQEHREPKRpei.....40ilfLSSIIPFD 118 VT.....SAKQDE........N....MTRFLGKLASQEHREPKRpei.....40ilfLSSIIPFD 119 VT.....SAKQDE........N....MTRFLGKLASQEHREPKRpei.....57gdlRFTPIPLL 20 230 240 250 260 | | | | | 1 rr66rvpEDRLALSNC........PL...ASRAIEYLVS........N.IIDNFDATNhRAFYLK 2 edATGLKELQLQLASN........AL...KTAIKYLDLV........N.DAGNlGHYEIKQLDLN 3 edATGLKELQLQLASN........AL...KTAIKYLDLV........N.DAGNlGHYEIKQLDLN 4 edATGLKELQLQLASN........AL...KTAIKYLDLV........N.DAGNlGHYEIKQLDLN 5 RCGCVVTLLkns22ddl.......AL...SLPQKYSKLS........M.GACNALIGYLQLLSEQ 6 RCGCVVTLLkns22ddl.......AL...SLPQKYSKLS........M.GACNALIGYLQLLSEQ 7 LKLAMGSASALIKYLG........IL...HDPSNfGQYQ........L.YQHDLAQFMKLDAAAL 8 ALVTTIrss23pvtHA........LV...PELGLQLAMA........S.CNALLRYLGPALLNpd 9 ALVTTIrss23pvtHA........LV...PELGLQLAMA........S.CNALLRYLGPALLNpd 10 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELATFDF 11 qinSAALPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELATFDF 12 qinSAALPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELATFDF 13 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 14 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 15 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 16 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 17 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 18 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 19 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 20 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 21 qvtSAALPEMEKQVAM........SA...LAAVMKYLEL........L.SDESNfGQFVMTNFDL 22 FDYALGPLGALLSYAE........LL...ADDTNyGNYT........I.EKYNLNCYMRLDSAAV 23 FDLATPALGALLSFSE........LL...SNEDNyGNFT........I.RRYDIGGFMRLDSAAM 24 FDLATPALGALLSFSE........LL...SNEDNyGNFT........I.RRYDIGGFMRLDSAAM 25 AEKQNENIKECLQILH........SN...AADEYsisEK........Y.SIFNYGTHGNMLIDSC 26 sTASSNMVTGRLVQNA........FE...----------........-.---dVIHGIRYIDIRD 27 GRLVQNAFE-------........--...-----dVIHG........I.RYIDIRDRMVLDENTI 28 RTLALGALAVLLKYIH........ET...RCVFFrvKSL........R.IKEMGVNDTCMIDFVS 29 KYYCLAAVAALLKYVE........FI...QNSVYapKSL........K.ICFQGSEQTAMIDSSS 30 KYYCLAAVAALLKYVE........FI...QNSVYapKSL........K.ICFQGSEQTAMIDSSS 31 KTFALCAASAAISYME........EI...ISKssrnl--naf.....R.KLRIQFEGTENTMLID 32 KTFALCAASAAISYME........EI...ISKssrnl--naf.....R.KLRIQFEGTENTMLID 33 DISCPLIHKQEydl12aik.....VM...NEKIQLSPSL........I.RLVSKLYSHMVEYNNE 34 DISCPLIHKQEydl12aik.....VM...NEKIQLSPSL........I.RLVSKLYSHMVEYNNE 35 QDDRIrve34gsqIIS........GI...VNLEKPVICS........L.AAIIKYLKEFNLEKMl 36 QDDRIrve34gsqIIS........GI...VNLEKPVICS........L.AAIIKYLKEFNLEKMl 37 DRIrve34gsqSLSGV........IN...LEKPVICALA........A.VIRYLKEFNLEKMlsK 38 DRIrve34gsqSLSGV........IN...LEKPVICALA........A.VIRYLKEFNLEKMlsK 39 DRIrve34gsqSLSGV........IN...LEKPVICALA........A.VIRYLKEFNLEKMlsK 40 VRKlkt55gsqSLSGV........IN...LEKPVICALA........A.VIRYLKEFNLEKMlsK 41 ----------------........--...----------........-.---------------- 42 RVEras46sclTVHTI........MN...MPHLTVQALA........L.TFCHLKQFGFERIlyQ 43 ----------------........--...----------........-.---------------- 44 RVEras46sclTVQTI........MN...MPHLTVQALA........L.TFCHLKQFGFERIlyQ 45 RVEras46sclTVHTI........MN...MPHLTVQALA........L.TFCHLKQFGFERIlyQ 46 TCGRVvrv36ielHME........KV...KSLHSLSIIC........L.DMAISYLMEFSLEDLf 47 TCGRVvrv36ielHME........KV...KSLHSLSIIC........L.DMAISYLMEFSLEDLf 48 QTRNPLVNNLVpls49mls.....EL...ATEDKNGSLA........L.SALGGAIYYLRQAFLD 49 QTRNPLVNNLVpls49mls.....EL...ATEDKNGSLA........L.SALGGAIYYLRQAFLD 50 LKEPVpgn44mdhLGL........TP...NDNYKLALKA........L.GQCIFFIHKCKLEPKv 51 EGLIpgs44sdsVGLT........PG...EESELALSAL........G.GIVFYLKKCLIDQEll 52 EGLIpgs44sdsVGLT........PG...EESELALSAL........G.GIVFYLKKCLIDQEll 53 EGLIpgs46sdsIGLT........PG...EKSELALSAL........G.GCVFYLKKCLIDQEll 54 EGLIpgs46sdsIGLT........PG...EKSELALSAL........G.GCVFYLKKCLIDQEll 55 EGLIpgs46sdsIGLT........PG...EKSELALSAL........G.GCVFYLKKCLIDQEll 56 EGLIpgs46sdsIGLT........PG...EKSELALSAL........G.GCVFYLKKCLIDQEll 57 EGLIpgs46sdsIGLT........PG...EKSELALSAL........G.GCVFYLKKCLIDQEll 58 PVEHLlpk41dssILP........KP...STDWQLALSA........F.GAIFWYLRDSLIDVDm 59 WNFIKpyt30apkILK........SY...LSEKPLAISA........F.GALFWYLRQLKLDKDm 60 evLKSYYDTGKKVGFS........AF...GGLLYYLKWL........K.LDKNliSMKNIKEYDF 61 evLKSYYDTGKKVGFS........AF...GGLLYYLKWL........K.LDKNliSMKNIKEYDF 62 ----------------........--...----------........-.-----DTAALENLELL 63 ----------------........--...----------........-.---------------- 64 DPSFIKYCTKLEVTAG........CT...LISYIADRLQ........N.SHpNIQPPIRVSLNEY 65 DPSFIKYCTKLEVTAG........CT...LISYIADRLQ........N.SHpNIQPPIRVSLNEY 66 ti21erqLKIQFQTFT........QK...ELAALRNTLI........Y.VSNHLPDFSiNFQIPQ 67 ti21erqLKIQFQTFT........QK...ELAALRNTLI........Y.VSNHLPDFSiNFQIPQ 68 RARGALLAYAQRTQGG........AL...SLQPFRFYDP........G.AFMRLPEATLRALEVF 69 RARGALLAYAQRTQGG........AL...SLQPFRFYDP........G.AFMRLPEATLRALEVF 70 RAQGALLAYARATQGG........AL...SVRPFRLYDP........G.AFVRLPEASLKALEVF 71 RAQGALLAYARATQGG........AL...SVRPFRLYDP........G.AFVRLPEASLKALEVF 72 RAQGALLAYARATQGG........AL...SVRPFRLYDP........G.AFVRLPEASLKALEVF 73 RARGALLAYARATQGG........AL...SVRPFRLYDP........G.AIVRLPEASLKALEVF 74 EDTYSLPLGAVYKYAK........TT...QKGYTpLIPR........P.KPYRDEGFVRLDIKAI 75 DEDLSLSLGAVYRYAK........AT...QKSFTpLIPK........P.KPYVDEGYVKLDLKAV 76 SPLALKALAALIKYVK........YT...MIGEDlNLKP........P.LLISQRDYMILDSATV 77 SPLALKALAALIKYVK........YT...MIAEDlNLKP........P.LLISQRDYMILDSATV 78 ----------------........--...----------........-.---------------- 79 ----------------........--...----------........-.---------------- 80 LPLAIRAAGGLLEYIE........DT...QKAHVvPIQP........L.KTYGLTDFLVLDHQTR 81 LPLAIRAAGGLLEYIE........DT...QKAHVvPIQP........L.KTYGLTDFLVLDHQTR 82 TASSKLLQYVHRTQMR........ELn..HLKPVIRYEI........K.DFLQMDYATKASLDLV 83 QATQLLLDYIHHTQKR........DLs..HIEDVVQYAA........I.DYMKMDFYAKRNLELT 84 KTFLRLYTYLKRTQKR........SLd..HLQPVQVYEL........E.EAMKIDLYSKRNLELT 85 KTFLRLYTYLKRTQKR........SLd..HLQPVQVYEL........E.EAMKIDLYSKRNLELT 86 NPQATAAAGALLGYIE........ET...QKQRLpHLTS........I.TMETVGEAITMNAATR 87 AKLGLCAAGCLIQYVK........DT...QRTALpHIRS........L.TWDRQDQSVILDAATR 88 ASRGLCAAGCLLQYVK........DT...QRTSLpHIRS........I.TMERQQDSIIMDAATR 89 ASRGLCAAGCLLQYVK........DT...QRTSLpHIRS........I.TMERQQDSIIMDAATR 90 APRGLCAAGCLLQYAK........DT...QRTTLpHIRS........I.TMEREQDSIIMDAATR 91 APRGLCAAGCLLQYAK........DT...QRTTLpHIRS........I.TMEREQDSIIMDAATR 92 APRGLCAAGCLLQYAK........DT...QRTTLpHIRS........I.TMEREQDSIIMDAATR 93 SPLGLSAAGCLLQYAK........ET...QRTALpHIQS........I.SLIQNQDCIQLDAATR 94 LTLAIGAAGCLLAYAK........ET...QRTALpHLRS........L.RHDRLDDTVILDGASR 95 LTLAIGAAGCLLAYAK........ET...QRTALpHLRS........L.RHDRLDDTVILDGASR 96 LGLAIGAAGCLLAYAR........ET...QRTALpHLRG........L.RHERLDDTVILAGASR 97 HAVAIGAAGALLNYIR........LT...QNLMPqHLDG........L.SLETDSQYIGMDAATR 98 HAVAIGAAGALLNYIR........LT...QNLMPqHLDG........L.SLETDSQYIGMDAATR 99 SRAELAAASAAVSYVE........KT...QLQERpALGI........P.ERESAASTLFIDPATR 100 SNSQICAIGSILEYLS........LT...QKQNIpHLPI........P.KIINFHNYMTIDFSTR 101 HSPDLAAAGALIAYLE........ET...TRHPLsHVSA........I.TRYHIHDFVEIDDATR 102 LVPAINAAGALLSYIQ........DK...LLLPIsHLSI........P.KIYGQHKHLLIDKASQ 103 LVPAINAAGALLSYIQ........DK...LLLPIsHLSI........P.KIYGQQKHLLIDKASQ 104 LVPAINAAGGLLSYIQ........DK...LLLPTkHIAI........P.QTRGKQQKLLIDTASQ 105 LVPAINAAGGLLSYIQ........DK...LLLPTkHIAI........P.QTRGKQQKLLIDTASQ 106 EKPYYISIFLIINHIK........NN...LKNLLsNIDK........I.DINNDSSYMFLDDVTQ 107 CDVALSALGELINHLS........RL...KLEDVlkHGD........I.FPYQVYRGCLRIDGQT 108 CDVALSALGELINHLS........RL...KLEDVlkHGD........I.FPYQVYRGCLRIDGQT 109 QDVVICALGGLIGHLT........RL...MLHDAlkNGE........V.LPYHVYKTCLRMDGQT 110 QDVVICALGGLIGHLT........RL...MLHDAlkNGE........V.LPYHVYKTCLRMDGQT 111 NQANLISLLGVLQFIK........DR...NPNLIkNLQL........P.ECYNSvvsPLNLILCN 112 AVNMIRSFGALLLFLD........ET...RMGvtddpls........V.-tsPIKSIKTFTLGNL 113 AVNMIRSFGALLLFLD........ET...RMGvtddpls........V.-tsPIKSIKTFTLGNL 114 AVNMIRSFGALLLFLD........ET...RMGvtddpls........V.-tsPIKSIKTFTLGNL 115 CVLTVRALGGLLKFLS........RR...RIGveledyd........-.VgvPILGFKKFVLTHL 116 CVLTVRALGGLLKFLS........RR...RIGveledyd........-.VgvPILGFKKFVLTHL 117 CLLTVRALGGLLKFLG........RR...RIGveledynv.......S.-vPILGFKKFMLTHLV 118 CLLTVRALGGLLKFLG........RR...RIGveledynv.......S.-vPILGFKKFMLTHLV 119 IPSQVRALGGLLKFLG........RR...RIGveledynv.......S.-vPILGFKKFMLTHLV 270 280 290 300 310 | | | | | 1 HTIPST........FMKLDTAAIQAL.HIIHQKPEArgslpTSVYSWLNRCVTGM........GS 2 RFVHLD........SAAVAALNIMPK.PGTHpsmpsyrwQSVLGVLDHCRTPQGH........RL 3 RFVHLD........SAAVAALNIMPK.PGTHpsmpsyrwQSVLGVLDHCRTPQGH........RL 4 RFVHLD........SAAVAALNIMPK.PGTHpsmpsyrwQSVLGVLDHCRTPQGH........RL 5 DQvGKY........ELVEHKLKEFMK.LDASAIKALNLFPQGPQNpfg21gkvTS........LF 6 DQvGKY........ELVEHKLKEFMK.LDASAIKALNLFPQGPQNpfg21gkvTS........LF 7 KALNLM........PGARDGaknMSL.YGLLNHCKTPVGSRLLSQWLKQPLMNAE........EI 8 meddre........-NtsRKLHLYHH.NLEQYMRLDIAAVRSLNLLPPPNGNahkt.......MS 9 meddre........-NtsRKLHLYHH.NLEQYMRLDIAAVRSLNLLPPPNGNahkt.......MS 10 SQYMKL........DMAAVRALNLFQ.GSVEDttgsQSLAAFLNKCKTAQGQRLV........SQ 11 SQYMKL........DMAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTAQGQRLV........NQ 12 SQYMKL........DMAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTAQGQRLV........NQ 13 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQGQRLV........NQ 14 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQGQRLV........NQ 15 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQGQRLV........NQ 16 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQGQRLV........NQ 17 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQGQRLV........NQ 18 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQGQRLV........NQ 19 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQG----........-- 20 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQGQRLV........NQ 21 SQYMKL........DNAAVGALNLFP.GSAEDtsgtQSLAGLLNKCKTPQGQRLV........NQ 22 RALNIA........EGKTDVnknFSL.FGLMNRTCTvGMGKRLLNRWLKQPLLDV........NE 23 RALNVM........ESKTDAnknFSL.FGLMNRTCTaGMGKRLLHMWLKQPLVDL........NE 24 RALNVM........ESKTDAnknFSL.FGLMNRTCTaGMGKRLLHMWLKQPLVDL........NE 25 AVEALE........LFQLNYNYleksnnLTLYNVLNKCKTLPGEKLLRDWLSRPL........CQ 26 RMVLDE........NTISALHIFPTA.HKLghd10ngfFSVFELFNQVSSDYARR........IL 27 SALHIF........PTAHKLghd10ngfFSVFELFNQVSSDYARRILKSWLINPL........TN 28 WESLEI........VDADDASkar10kqkRTLMSVLNHTVTTNGYRLLRSSVLQP........ST 29 AQNLEL........LINNQDYrnnHT.LFGVLNYTKTPGGSRRLRSNILEPLVDI........ET 30 AQNLEL........LINNQDYrnnHT.LFGVLNYTKTPGGSRRLRSNILEPLVDI........ET 31 SKTVRG........LELVENKLDKng.ISLWKFLDTTSTKMGQRSLRNSILQPLT........DR 32 SKTVRG........LELVENKLDKng.ISLWKFLDTTSTKMGQRSLRNSILQPLT........DR 33 QVmlIP........SIYSPFASKIHM.LLDPNSLQSLDIFTHDGGKGSLFWLLDH........TR 34 QVmlIP........SIYSPFASKIHM.LLDPNSLQSLDIFTHDGGKGSLFWLLDH........TR 35 sKPENF........KQLSSKmEFMTI.NGTTLRNLEILQNQTDMktkGSLLWVLD........HT 36 sKPENF........KQLSSKmEFMTI.NGTTLRNLEILQNQTDMktkGSLLWVLD........HT 37 PESFKQ........LSSGmEFMRING.TTLRNLEMVQNQTDMktkGSLLWVLDHT........KT 38 PESFKQ........LSSGmEFMRING.TTLRNLEMVQNQTDMktkGSLLWVLDHT........KT 39 PESFKQ........LSSGmEFMRING.TTLRNLEILQNQTDMktkGSLLWVLDHT........KT 40 PESFKQ........LSSGmEFMRING.TTLRNLEILQNQTDMktkGSLLWVLDHT........KT 41 ------........------------.----------------------------........-- 42 GASFRS........LSSNTEMTLSAN.TLQQLEVVKNNSDGsesGSLFHNMNHTL........TV 43 ------........------------.----------------------------........-- 44 GASFRS........LSSNTEMTLSAN.TLQQLEVVKNNSDGsesGSLFHNMNHTL........TV 45 GASFRS........LSSNTEMTLSAN.TLQQLEVVKNNSDGsesGSLFHNMNHTL........TV 46 vASNFY........QPFDSISSMVLS.KQALEGLELFVNQTDHtpvGSLFWVLDR........TY 47 vASNFY........QPFDSISSMVLS.KQALEGLELFVNQTDHtpvGSLFWVLDR........TY 48 esl10kfe......SLPYCDFSNVNE.KQHMVLDAAALENLEIFENSRNGgysGT........LY 49 esl10kfe......SLPYCDFSNVNE.KQHMVLDAAALENLEIFENSRNGgysGT........LY 50 lPMARY........QLYVPpdq16tlrRSHMVLDATTLSNLRII---GEEHSLLS........TL 51 SMANFE........EYFPlds18tka.SQRMVLDAVTLNNLEIFLNGTNGsteGN........LL 52 SMANFE........EYFPlds18tka.SQRMVLDAVTLNNLEIFLNGTNGsteGT........LL 53 SMANFE........EYIPlds18tka.YQRMVLDAVTLNNLEIFLNGTNGsteGT........LL 54 SMANFE........EYIPlds18tka.YQRMVLDAVTLNNLEIFLNGTNGsteGT........LL 55 SMANFE........EYIPlds18tka.YQRMVLDAVTLNNLEIFLNGTNGsteGT........LL 56 SMANFE........EYIPlds18tka.YQRMVLDAVTLNNLEIFLNGTNGsteGT........LL 57 SMANFE........EYIPlds18tka.YQRMVLDAVTLNNLEIFLNGTNGsteGT........LL 58 lSMRNV........TIYNSnsm15dwnGKNLILDGTALENLNIVPNGRDShlTSL........YY 59 cSMGNF........DEYDAsqqSTSL.LMNGQTLKNLEIFSNSFDGgseGTLFHL........LC 60 vksQHS........MVLDGITLQNLE.IFSNSFDGsdkGTLFKLFNRAITPMGKR........MM 61 vksQHS........MVLDGITLQNLE.IFSNSFDGsdkGTLFKLFNRAITPMGKR........MM 62 ENTRTGgls.....GTLYAQLNHCVT.GFGKRLLKRWIAKPLYDCREILRRQSAV........AT 63 ------........------------.----------------------------........-- 64 MIIGES........AMKGLEIRSSLY.QNrytGSLLHAINKTVTKSGSRLLTRRL........CA 65 MIIGES........AMKGLEIRSSLY.QNrytGSLLHAINKTVTKSGSRLLTRRL........CA 66 RQLATA........IMQIDSRTSTAL.ELHSTVRDNnkkGSLLSSIRRTVTPSGT........RL 67 RQLATA........IMQIDSRTSTAL.ELHSTVRDNnkkGSLLSSIRRTVTPSGT........RL 68 EPLRGQ........DTLFSVLDETRT.APGRRLLQSWLRHPLLDRGPLEARLDRV........EG 69 EPLRGQ........DTLFSVLDETRT.APGRRLLQSWLRHPLLDRGPLEARLDRV........EG 70 EPLRGQ........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV........ER 71 EPLRGQ........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV........ER 72 EPLRGQ........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV........ER 73 EPLRGQ........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV........ER 74 KGLEIL........ESLEGRkdISLF.KVIDRTLTGMGRRRLKFRLLSPFRSREK........IE 75 KGLEIT........ESIEGRkdLSLF.KVVDRTLTGMGRRRLRFRLLNPFRSIER........IR 76 ENLSWI........PGDRGKn--LFD.VLNNTETPMGARLGKKWILHPLVDRKQI........EE 77 ENLSLI........PGDRGKn--LFD.VLNNTETPMGARLLKKWILHPLVDRKQI........EE 78 ------........------------.----------------------------........-- 79 ------........------------.----------------------------........-- 80 RNLEIN........QTVRDGsfhGSL.LWALDRTSTTMGSRALRRWLLQPLLDLK........GI 81 RNLEIN........QTVRDGsfhGSL.LWALDRTSTTMGSRALRRWLLQPLLDLK........GI 82 ENARSGkkq.....GSLFWLLDETKT.AMGMRLLRSWIHRPLIDKERIVQRQEVV........QV 83 ESIRLKskk.....GTLLWLMDETKT.PMGARRLKQWIDRPLISKEQIEARLDIV........DE 84 ETIRSKnkk.....GSLLWLLDETKT.AMGGRLLKQWIDRPLIRVNQIEERQEMV........ET 85 ETIRSKnkk.....GSLLWLLDETKT.AMGGRLLKQWIDRPLIRVNQIEERQEMV........ET 86 RHLELD........TRVDGEsrHTLL.GVLDSTVTPMGGRLLRRWLHRPLRLREV........VR 87 RNLELT........HNLAGGtdNTLA.EVLDHCATPMGSRMLKRWIHQPMRDNAT........LN 88 RNLEIT........QNLAGGveNTLA.AVLDCTVTPMGSRMLKRWLHMPVRNTDI........LR 89 RNLEIT........QNLAGGveNTLA.AVLDCTVTPMGSRMLKRWLHMPVRNTDI........LR 90 RNLEIT........QNLAGGaeNTLA.SVLDCTVTPMGSRMLKRWLHMPVRDTRV........LL 91 RNLEIT........QNLAGGaeNTLA.SVLDCTVTPMGSRMLKRWLHMPVRDTRV........LL 92 RNLEIT........QNLAGGaeNTLA.SVLDCTVTPMGSRMLKRWLHMPVRHTRV........LL 93 RNLELT........QNLAGGteNTLA.SVLDKCVTPMGSRLLKRWIHQPVRDVEK........LK 94 RNLELD........INLSGGreNTLQ.SVVDRCQTAMASRLMSRWLNRPLRDRAV........LE 95 RNLELD........INLSGGreNTLQ.SVVDRCQTAMASRLMSRWLNRPLRDRAV........LE 96 RNLELD........VNLSGGrdNTLQ.SVIDRCQTAMGSRLLGRWLNRPLRDRAV........LE 97 RNLEIT........QTLSGKksPTLM.STLDLCATHMGSRLLALWLHHPLRNRAH........IR 98 RNLEIT........QTLSGKksPTLM.STLDLCATHMGSRLLALWLHHPLRNRAH........IR 99 ANLELA........KTLSGSrdGSLL.KSLDRTMTSGGARLLAERLMSPLTDPER........IN 100 RNLEIV........TNLQGNlyGSVL.NTLNHTVTTQGGRLLYHFLSSPLTNIAK........IN 101 KNLEIL........QNLHDSthaHSL.FETLNYTHTAMGTRLLRYWLHHPLRSQE........EI 102 TNLELL........SAIHGEhgkGSL.LQVMERTSTPMGGRLLRNTLVNPFYDLK........EI 103 TNLELL........SPIHGEhgkGSL.LQVMERTSTPMGGRLLRNTLINPFYDLK........EI 104 VNLELL........APLNDPqgkNSL.LRIMDHTSTPMGGRLLRQILISPFYNPK........EI 105 VNLELL........APLNDPqgkNSL.LRIMDHTSTPMGGRLLRQILISPFYNPK........EI 106 VNLELV........KNNNDFssqYSL.YSVLNDCKTAMGKRLLREFILNPILNIS........EI 107 MVNLEI........FNNSCDGvlqGP.LNKYLENCVSPTGKRLLRNWICHPLKDV........ES 108 MVNLEI........FNNSCDGgpsGT.LYKYLDNCVSPTGKRLLRNWICHPLKDV........ES 109 LVNLEI........FINNFNGgssGT.LYKHLNHCVTASGKRMLRRWICHPLKDI........DA 110 LVNLEI........FINNFNGgssGT.LYKHLNHCVTASGKRMLRRWICHPLKDI........DA 111 RAEYQL........DLLSKRGKLGGL.LNLIDYCSTAMGKRLLKFRLLNPITDYS........EL 112 VEIDFN........TIQALDILPKET.ENkktfgqgRSLYQLMDKCRSTVGKKCL........RK 113 VEIDFN........TIQALDILPKET.ENkktfgqgRSLYQLMDKCRSTVGKKCL........RK 114 VEIDFN........TIQALDILPKET.ENkktfgqgRSLYQLMDKCRSTVGKKCL........RK 115 VSIDQD........TYSVLQIFKSES.HPsvy12kegLSLFGILNRCRCKWGQKL........LR 116 VSIDQD........TYSVLQIFKSES.HPsvy12kegLSLFGILNRCRCKWGQKL........LR 117 NIDQDT........YSVLQIFKSESH.Psvy12kegLSLFGILNRCHCKWGEKLL........RL 118 NIDQDT........YSVLQIFKSESH.Psvy12kegLSLFGILNRCHCKWGEKLL........RL 119 NIDQDT........YSVLQIFKSESH.Psvy12kegLSLFGILNRCHCKWGEKLL........RL 320 330 340 350 | | | | 1 RM.......MRQWLLQPLR...N........AEDINQRLSLVELMVE........DSILRDALLs 2 MG.......QWVKQPLRSR...N........ILNDRHNIVQCLLESP........DTMETLSlDY 3 MG.......QWVKQPLRSR...N........ILNDRHNIVQCLLESP........DTMETLSlDY 4 MG.......QWVKQPLRSR...N........ILNDRHNIVQCLLESP........DTMETLSlDY 5 QL.......LNHCKTNAGV...R........LLNEWLKQPLTNIDEI........NKRHDLVDYL 6 QL.......LNHCKTNAGV...R........LLNEWLKQPLTNIDEI........NKRHDLVDYL 7 EK.......RQQLVEAFAN...D........TELRQSMQeEHLRSIP........DLYRLSKRFQ 8 LY.......GLLNHCRTAM...G........ARNLRRWIVQPLLDAK........SIERRHDLVS 9 LY.......GLLNHCRTAM...G........ARNLRRWIVQPLLDAK........SIERRHDLVS 10 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDSELR........RALQeDLLRR 11 WI.......KQPLMDRNRI...E........ERLNLVEAFVEDSELR........QSLQeDLLRR 12 WI.......KQPLMDRNRI...E........ERLNLVEAFVEDSELR........QSLQeDLLRR 13 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDAELR........QTLQeDLLRR 14 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDAELR........QTLQeDLLRR 15 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDAELR........QTLQeDLLRR 16 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDAELR........QTLQeDLLRR 17 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDAELR........QTLQeDLLRR 18 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDAELR........QTLQeDLLRR 19 --.......----------...-........----------------........---------- 20 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDAELR........QTLQ------ 21 WI.......KQPLMDKNRV...E........ERLNLVEAFVMDVELR........QCLQeDLLRR 22 IN.......NRLDMVQAFV...E........DPELRQGLRQQLKRIS........DIDRLTHSLR 23 IK.......TRLDIVQCFV...E........EAGLRQDLRQHLKRIS........DVERLLRSLE 24 IK.......TRLDIVQCFV...E........EAGLRQDLRQHLKRIS........DVERLLRSLE 25 ID.......HINERLDIVE...A........LFENQTIRQKLRdSIL........ARMPDCSQLA 26 KS.......WLINPLTNKK...R........IETRYSIIRTLLdkQN........AIIFSDLSQS 27 KK.......RIETRYSIIR...T........LLdkQNAIIFSDLSQS........IKRCPDAFGF 28 DV.......YLIQSRQEAI...E........ELIGKPQLKDKLRRTL........SRAHELDRVI 29 IN.......MRLDCVQELL...Q........DEELFFGLQSVISRFL........DTEQLLSVLV 30 IN.......MRLDCVQELL...Q........DEELFFGLQSVISRFL........DTEQLLSVLV 31 GS.......IEMRLEALEE...L........KANDDLLQKLRLEMKS........LPDLDKLFSR 32 GS.......IEMRLEALEE...L........KANDDLLQKLRLEMKS........LPDLDKLFSR 33 TS.......FGLRMLREWI...L........KPLVDVHQIEERLDAI........ECITseiNNS 34 TS.......FGLRMLREWI...L........KPLVDVHQIEERLDAI........ECITseiNNS 35 KT.......SFGRRKLKKW...V........TQPLLKLREINARLDA........VSEVLhSESS 36 KT.......SFGRRKLKKW...V........TQPLLKLREINARLDA........VSEVLhSESS 37 SF.......GRRKLKNWVT...Q........PLLKLREINARLDAVS........DVLhSESSVF 38 SF.......GRRKLKNWVT...Q........PLLKLREINARLDAVS........DVLhSESSVF 39 SF.......GRRKLKNWVT...Q........PLLKLREINARLDAVS........DVLhSESSVF 40 SF.......GRRKLKNWVT...Q........PLLKLREINARLDAVS........DVLhSESSVF 41 --.......----------...-........----------------........---------- 42 YG.......SRLLRHWVTH...P........LCDRNLISARLDAVsei.......16qlsSELVE 43 --.......----------...-........----------------........---------- 44 YG.......SRLLRHWVTH...P........LCDRNLISARLDAVsei.......16qlsSELVE 45 YG.......SRLLRHWVTH...P........LCDRNLISARLDAVsei.......16qlsSELVE 46 TR.......FGQRMLQRWL...Q........KPLVDKENIIERLDAV........EELAfNSNSQ 47 TR.......FGQRMLQRWL...Q........KPLVDKENIIERLDAV........EELAfNSNSQ 48 AQ.......LNQCITASGK...R........LLKTWLARPLYNTELI........KERQDAVAIL 49 AQ.......LNQCITASGK...R........LLKTWLARPLYNTELI........KERQDAVAIL 50 DH.......CCTKFGKRLL...H........HWLCAPSCDVSVIKER........QDAIGELIRM 51 ER.......LDTCHTPFGK...R........LLKQWLCAPLCSPSAI........SDRLDAVEDL 52 ER.......LDTCHTPFGK...R........LLKQWLCAPLCSPSAI........SDRLDAVEDL 53 ER.......VDTCHTPFGK...R........LLKQWLCAPLCNHYAI........NDRLDAIEDL 54 ER.......VDTCHTPFGK...R........LLKQWLCAPLCNHYAI........NDRLDAIEDL 55 ER.......VDTCHTPFGK...R........LLKQWLCAPLCNHYAI........NDRLDAIEDL 56 ER.......VDTCHTPFGK...R........LLKQWLCAPLCNHYAI........NDRLDAIEDL 57 ER.......VDTCHTPFGK...R........LLKQWLCAPLCNHYAI........NDRLDAIEDL 58 VI.......NKCSTPFGRR...L........LRSWLLQPTCDPKKLE........QRQKAIKWLV 59 RC.......VTPFGKRLFH...T........WLCHPLRSGTAINARL........DVVELIADNP 60 KK.......WLMHPLLRKN...D........IESRLDSVDSLLQDIT........LREQLEITFS 61 KK.......WLMHPLLRKN...D........IESRLDSVDSLLQDIT........LREQLEITFS 62 FKg......VGQDCAAQFR...K........DLSRLPDMERLLARLFssc.....14vvlYEDAS 63 --.......----------...-........----------------........---------- 64 PS.......TNIVEINNRL...D........LVEKFKLLPELCSKVI........NLLKKSNDTH 65 PS.......TNIVEINNRL...D........LVEKFKLLPELCSKVI........NLLKKSNDTH 66 LS.......QWLSGPSLDL...K........EIKKRQKIVAFFKDNR........DITENLRTML 67 LS.......QWLSGPSLDL...K........EIKKRQKIVAFFKDNR........DITETLRTML 68 FV.......REGALREGVR...R........LLYRLADLERLATRLE........LGRASPKDLG 69 FV.......REGALREGVR...R........LLYRLADLERLATRLE........LGRASPKDLG 70 FV.......REGALREGVR...R........LLFRLADLERLATRLE........LSRASPRDLA 71 FV.......REGALREGVR...R........LLFRLADLERLATRLE........LSRASPRDLA 72 FV.......REGALREGVR...R........LLFRLADLERLATRLE........LSRASPRDLA 73 FV.......REGALREGVR...R........LLFRLADLERLATRLE........LSRASPRDLA 74 RI.......QEGVQELKEN...R........EALLKIRQILEGMADL........ERLVSKISSN 75 KV.......QEAVEELINK...R........EVLNEIRKTLEGMSDL........ERLVSRISSN 76 RL.......KAVERLVNDR...V........SLEEMRNLLSNVRDVE........RIVSRVEYNR 77 RL.......KAVERLVNDR...V........SLEEMRNLLSNVRDVE........RIVSRVEYNR 78 --.......---GIGVDVS...P........VMIKVVDAAVQKARIG........LRNARPRDLA 79 --.......----------...-........----------------........---------- 80 QA.......RQDTIQELYH...H........PALRQDLRQLLRQIYD........LERLTGRIGA 81 QA.......RQDTIQELYH...H........PALRQDLRQLLRQIYD........LERLTGRIGA 82 FL.......DHFFERSDLT...D........SLKGVYDIERLASRVS........FGKTNPKDLL 83 FS.......AHFIERDTLR...T........YLNQVYDIERLVGRVS........YGNVNARDLI 84 LM.......SHFFEREDLR...E........RLKEVYDLERLAGRVA........FGNVNARDLI 85 LM.......SHFFEREDLR...E........RLKEVYDLERLAGRVA........FGNVNARDLI 86 QR.......HAAVGSMI-D...R........DLDNKLMETFRRLGDM........ERILTRVALR 87 QR.......LDAITELK-E...T........ALYGELHPVLKQIGDI........ERILARLALR 88 ER.......QQTIGALQ--...-........DTVSELQPVLRQVGDL........ERTPC----A 89 ER.......QQTIGALQ--...-........DTVSELQPVLRQVGDL........ERTPC----A 90 ER.......QQTIGALQ--...-........DFTAGLQPVLRQVGDL........ERILARLALR 91 ER.......QQTIGALQ--...-........DFTAELQPVLRQVGDL........ERILARLALR 92 ER.......QQTIGALQ--...-........DFTAELQPVLRQVGDL........ERILARLALR 93 QR.......QQSIAEIL-N...F........DLVDELQPYLQLVGDM........ERILARVALR 94 AR.......QESIACLL-E...R........YRFENLQPQLKEIGDL........ERILARIGLR 95 AR.......QESIACLL-E...R........YRFENLQPQLKEIGDL........ERILARIGLR 96 AR.......QDTVACLLQD...-........YRFESLQPQLKEIGDV........ERILARIGLR 97 AR.......QEAVAALE--...-........SQYKPLQCRLKNIADI........ERIAARIAVG 98 AR.......QEAVAALE--...-........SQYKPLQCRLKSIADI........ERIAARIAVG 99 QR.......LDSIEVLADQ...P........RFTTDVRDALRRAPDM........PRALSRLALG 100 HR.......LNITEFFYSN...L........GIVTRIRELLKNTSDI........ERCLTRITMN 101 QK.......RLSAVVFFHH...R........PHILKTLRATLSCVRD........VERLVARVAL 102 TL.......RQDSVEFFLK...Q........EPLRKTLKRHLSCVRD........LERLATKIST 103 TL.......RQDSVEFFLQ...Q........ADLRKILKRQLSCVRD........LERLATKIST 104 LV.......RQDAVEFFLR...Q........VTLRKNIKTYLCQVRD........IERLMTKVTT 105 LV.......RQDAVEFFLR...Q........VTLRKNIKTYLCQVRD........IERLMTKVTT 106 NT.......RLDHVEFFCK...N........ISLTVTLRETFINIWD........IERIISRIQM 107 IN.......KRLDVVEEFT...A........NSESMQITGQYLHKLP........DLERLLGRIK 108 IN.......KRLDVVEEFT...A........NSESMQITGQYLHKLP........DLERLLGRIK 109 IN.......KRLDVVEGFI...Q........NCGLGPTTLGYLQKIP........DLERLLGQVR 110 IN.......KRLDVVEGFI...Q........NCGLGPTTLGYLQKIP........DLERLLGQVR 111 NL.......RYKDISIFKR...L........LNQKIFDNSELKCIKD........LSSLHRQWAi 112 WF.......RNPTTDRDDL...V........SRQKCVHYFKqdWNAE........VTAKLSSILG 113 WF.......RNPTTDRDDL...V........SRQKCVHYFKqdWNAE........VTAKLSSILG 114 WF.......RNPTTDRDDL...V........SRQKCVHYFKqviifkv.......EYRNLWEIFL 115 LW.......FTRPTRELRE...L........NSRLDVIQFFLmpQNL........DMAQMLHRLL 116 LW.......FTRPTRELRE...L........NSRLDVIQFFLmpQNL........DMAQMLHRLL 117 WF.......TRPTHDLGEL...S........SRLDVIQFFLlpQNLD........MAQMLHRLLG 118 WF.......TRPTHDLGEL...S........SRLDVIQFFLlpQNLD........MAQMLHRLLG 119 WF.......TRPTHDLGEL...S........SRLDVIQFFLlpQNLD........MAQMLHRLLG 360 370 380 390 4 | | | | 1 QV.LRCCGDMDRLNRKLQRRSI........ALKDLQSILTFVNTIPRAVQ........VLRTHQG 2 LK.RIPDILMLTKKLMRRKANL........QDLFRIYQVILRTPKILKVL........HELDNst 3 LK.RIPDILMLTKKLMRRKANL........QDLFRIYQVILRTPKILKVL........HELDNst 4 LK.RL-----------------........--------------------........------- 5 ID.QIELRQMLTsEYLPMIPDI........RRLTKKLN-KRGNLEDVLKI........YQFSKRI 6 ID.QIELRQMLTsEYLPMIPDI........RRLTKKLN-KRGNLEDVLKI........YQFSKRI 7 RG.KATLEDVVRAYQVVIRLPG........FIGTLEGVMDeay18relSD........SLVKLQE 8 AL.VEDAEARQLLLdddHLLRS........IPDIPKLCRRLTRGSASLED........VVRIYQM 9 AL.VEDAEARQLLLdddHLLRS........IPDIPKLCRRLTRGSASLED........VVRIYQM 10 FP.DLNRLAKKFQRQAANLQDC........YRLYQGVKQLPNVIQALEKY........QGrhq17 11 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPSVIQALEKY........EGrhq17 12 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPSVIQALEKY........EGrhq17 13 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPNVIQALEKH........EGkhq17 14 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPNVIQALEKH........EGkhq17 15 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPNVIQALEKH........EGkhq17 16 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPNVIQALEKH........EGkhq17 17 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPNVIQALEK-........------- 18 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPNVIQALEKH........EGkhq17 19 --.-------------------........--------------------........------- 20 --.-------------------........--------------------........------- 21 FP.DLNRLAKKFQRQTANLQDC........YRLYQAVNHLPTVVQAIEKY........EGthq17 22 KK.SANLQPVVKLYQSCSRIPY........IKGILQQYNGqfs19wmaKN........RFGRFSS 23 RR.RGGLQHIIKLYQSTIRLPF........IKTAMQQYTGefa19lsdQD........HLGKFID 24 RR.RGGLQHIIKLYQSAIRLPF........IKTAMQQYTGefa19lsdQD........HLGKFID 25 RR.LM-RKCTLQDLNRFYQAAT........LLETVEMQLIQLSEaeq18ite......ILKKVER 26 IK.RCPDAFGFINQLRSGKSTL........GTWSKVASFLEKGIAIFQLV........SSLKLgs 27 IN.QLRSGKSTLGTWSKVASFL........EKGIAIFQLVSSLKLgsd16kvd.....ISALKEC 28 AM.CIqts9wtvrESEAKINQI........IKLMHTLKVIQGIRTLLHSA........KMksn13 29 qip9dtvnAAESKITNLIYLKH........TLELVDPLKIAMKNCNTpll........11sleDK 30 qip9dtvnAAESKITNLIYLKH........TLELVDPLKIAMKNCNTpll........11sleDK 31 LLcinhsaiKPDQRINYVLLLK........ETLQSVKSLKDALNDQLIqsr.......13ifnND 32 LLcinhsaiKPDQRINYVLLLK........ETLQSVKSLKDALNDQLIqsr.......13ifnND 33 IF.FESLNQMLNHTPDLLRTLN........RIMYGTTSRKEVYFYLKQIT........SFVDHFK 34 IF.FESLNQMLNHTPDLLRTLN........RIMYGTTSRKEVYFYLKQIT........SFVDHFK 35 VF.GQIENHLRKLPDIGRGLCS........IYHKKCSTQEFFLIVKTLYH........LKSEFQA 36 VF.GQIENHLRKLPDIERGLCS........IYHKKCSTQEFFLIVKTLYH........LKSEFQA 37 EQ.IENLLRKLPDVERGLCSIY........HKKCSTQEFFLIVKSLCQLK........SELQALM 38 EQ.IENLLRKLPDVERGLCSIY........HKKCSTQEFFLIVKSLCQLK........SELQALM 39 EQ.IENLLRKLPDVERGLCSIY........HKKCSTQEFFLIVKSLCQLK........SELQALM 40 EQ.IENLLRKLPDVERGLCSIY........HKKCSTQEFFLIVKSLCQLK........SELQALM 41 --.-------------------........--------------------........------- 42 EG.SERAIVSPefy11vltAMS........RSSDIQRGITRIFHRTAKAT........EFIAVME 43 --.-------------------........--------------------........------- 44 EG.SERAIVSPefy11vltAMS........RSSDIQRGITRIFhrt23vpg.......SSSPGLR 45 EG.SERAIVSPefy11vltAMS........RSSDIQRGITRIFhrt23vpv.......SSSPGLR 46 VQ.AIRKMLYRLPDLEKGLSRI........Yyqr13afsKNSYSCFKSAL........LRRLIQQ 47 VQ.AIRKMLYRLPDLEKGLSRI........Yyqr13afsKNSYSCFKSAL........LRRLIQQ 48 Rg.ENLPYSLEFRKSLSRLPDM........ERLIARMFssi18yedTAKK........QVQEFIS 49 Rg.ENLPYSLEFRKSLSRLPDM........ERLIARMFssi18yedTAKK........QVQEFIS 50 PT.ELQEVRALLAPMPDFERNL........AQIHlfg24eklYNKQKLQG........FMAVLKG 51 MA.VPYKVTEVADLLKKLPDLE........RLLSKIHnvg23ettYSKKK........IIDFLSA 52 MA.VPDKVTEVADLLKKLPDLE........RLLSKIHnvg23ettYSKKK........IIDFLSA 53 MV.VPDKISEVVELLKKLPDLE........RLLSKIHnvg23ettYSKKK........IIDFLSA 54 MV.VPDKISEVVELLKKLPDLE........RLLSKIHnvg23ettYSKKK........IIDFLSA 55 MV.VPDKISEVVELLKKLPDLE........RLLSKIHnvg23ettYSKKK........IIDFLSA 56 MV.VPDKISEVVELLKKLPDLE........RLLSKIHnvg23ettYSKKK........IIDFLSA 57 MV.VPDKISEVVELLKKLPDLE........RLLSKIHnvg23ettYSKKK........IIDFLSA 58 sp.DASSFMTTATATLKKIPDL........DRLLQKIHtig23tikTNQK........KIAELLA 59 VI.RDTIWGFLHKLPDLERLIS........RVHAGRSKPADFVRVLEGFQ........RINSAFD 60 KL.PDLERMLARIHSRTIKVKD........FEKVITAFETIIELQDSLKN........NDLKGDV 61 KL.PDLERMLARIHSRTIKVKD........FEKVITAFETIIELQDSLKN........NDLKGDV 62 KK.LLQQFTSALCGCQQMFHAC........SSISTlic18gkgLSNISSI........LDRFRDA 63 --.-------------------........--------------------........------- 64 RI.LQHLLMGRGNSYDLLKMAD........NFSITKEIHSLLSPLESssa........10llnMH 65 RI.LQHLLMGRGNSYDLLKMAD........NFSITKEIHSLLSPLESssa........10llnMH 66 KK.VNDLSRILQKFSFGRGEAL........ELIQMARSLEVSREIRKYLL........NNTSlmk 67 KK.VNDLSRILQKFSFGRGEAL........ELIQMARSLEVSREIRKYLL........NNTSlmk 68 AL.RRSLQILPELRALLGEEVG........LPDLSPLKEELEAALVEDPP........LKVSEGG 69 AL.RRSLQILPELRALLGEEVG........LPDLSPLKEELEAALVEDPP........LKVSEGG 70 AL.RRSLEILPELKGLLGEEVG........LPDLSGLLEELRAALVEDPP........LKVSEGG 71 AL.RRSLEILPELKGLLGEEVG........LPDLSGLLEELRAALVEDPP........LKVSEGG 72 AL.RRSLEILPELKGLLGEEVG........LPDLSGLLEELRAALVEDPP........LKVSEGG 73 ALrRRSLEILPELEGLLGEEVG........LPDLSGLLEELRAALVEDPP........LKVSEGG 74 MA.TPRELVYLKNSLKKVEELR........LLLLELKApif9ilqnFEDT........KKIINDI 75 MA.SPRELIHLKNSLRKAEELR........KILSLLDSeif9iegsLLNL........NKVADLI 76 SV.PRDLVALRETLEIIPKLNE........VLSTFGVfkkLAFPEGLVDL........LRKAIED 77 SV.PRDLVALRETLEIIPKLNE........VLSTFGVfkkLAFPEGLVDL........LRKAIED 78 RL.RDALGALPELQNAMTELEAphl.....9laaiTGTYPELASLLERAI........IDNPPAV 79 --.-------------------........--------------------........------- 80 NT.ASARDVYGLASSLVRLTDL........AELAQEGHSpyl9lqtvPPE........LEELGKY 81 NT.ASARDVYGLASSLVRLTDL........AELAQEGHSpyl9lqtvPPE........LEELGKY 82 QL.ATTLSSVPRIRAILEGMEQptl.....9liaqLDAIPELESLISAAI........APEAPHV 83 QL.KHSISEIPNIKALLNSMNQntlvqvnqLEPLDDLLDILEQSLVEEPP........ISVKDGG 84 QL.KESLKQVPGIKQLVASLAHdka.....9rakrIDPCGDVLELLEEAL........YENPPLS 85 QL.KESLKQVPGIKQLVASLAHdka.....9rakrIDPCGDVLELLEEAL........YENPPLS 86 SA.RPRDISTLRDSLSLLPRLR........ELLNASDSprl9lyaeLGEH........DSTASLL 87 SA.RPRDLARLRHAMQQLPELH........SVMSELKQphl9lrthAEPM........DELCDLL 88 SG.AAQPSARSRPNASRLPAAA........ELHAQLETvds11cvkKWAI........SPSCATS 89 SG.AAQPSARSRPNASRLPAAA........ELHAQLETvds12rkkMGDF........AELRDLL 90 TA.RPRDLARMRHAFQQLPELR........AQLETVDSapv9lrekMGEF........AELRDLL 91 TA.RPRDLARMRHAFQQLPELR........AQLETVDSapv9lrekMGEF........AELRDLL 92 TA.RPRDLARMRHAFQQLPELR........AQLETVDSapv9lrekMGEF........AELRDLL 93 SA.RPRDLTRLRTALEQIPALR........AIVQQKTPpfl9lfsqIADF........SEQCDLL 94 NA.RPRDLARLRDALAALPDLQ........NAMTELEAphl9lattIGTY........PELAELL 95 NA.RPRDLARLRDALAALPDLQ........NAMTELEAphl9lattIGTY........PELAELL 96 NA.RPRDLARLRDALAALPQLQ........TALSPLEAphl9lagnIRTY........PELAELL 97 NA.RPRDLASLRDSLFELAQID........LSANGSSLletlkavFPENL........STAEQLR 98 NA.RPRDLAALRDSLFALSEIE........LSAECSSLlgtlkavFPENL........STAEQLR 99 RG.GPRDLGAIQAGMRAAAAIS........ALLSGAELsae11daiAALP........GELLARL 100 RS.SGRDLLSIKYTLETAKTIK........GLFSESYGlnl13ikpLSGD........AELYNLI 101 EK.AHGRDLLALKESLRAILTF........RSLERESPFppd10egdTPV........LQELYGL 102 TL.ASPKDIGMLRDSLLSCMHI........AHDLQSYTLpef10cliSSS........LKSLIEA 103 SL.ATPKDIGTLRDSLLSCTHI........ADNLQNCALpef10fliAPP........LCSLIKT 104 GL.AGPRDIGTLRDSFSAGAQI........YEQLASATLpef10cslDTK........LASLIAL 105 GL.AGPRDIGTLRDSFSAGAQI........YEQLASATLpef10cslDTK........LASLIAL 106 KR.YIKKDFLFIEKALSVFFTV........KKLFDKHNFdywNFDKFEED........SISKVYF 107 SS.VRSSASVLPALLGKKVLKQ........RVKAFGQIVKgfr11llaLQ........KESNMMS 108 SS.VRSSASVLPALLGKKVLKQ........RVKAFGQIVKgfr11llaLQ........KESNMMS 109 --.--STVGLSSLLQLPFIGEK........IIK-----------------........------- 110 --.--STVGLSSLLQLPFIGEK........IIK-----------------........------- 111 cassDTTLPPKKLSQIYHSYLF........ACQLISKLTNNIQlpplvGP........QLKSLIK 112 RV.KALNSVFQKFQSGTAQLIH........WECFVSTVNALVEILNIIRQ........TPIske9 113 RV.KALNSVFQKFQSGTAQLIH........WECFVSTVNALVEILNIIRQ........TPIske9 114 NH.SKFSPDSEYLSEKIFlkk9........6kfqSGTAQLIHWECFVSTV........NALVEIL 115 SH.IKNVPLILKRMKLSHTKVS........DWQVLYKTVYSALGLRDACR........SLPQsiq 116 SH.IKNVPLILKRMKLSHTKVS........DWQVLYKTVYSALGLRDACR........SLPQsiq 117 HI.KNVPLILKRMKLSHTKVSD........WQVLYKTVYSALGLRDACRS........LPQsiq1 118 HI.KNVPLILKRMKLSHTKVSD........WQVLYKTVYSALGLRDACRS........LPQsiq1 119 HI.KNVPLILKRMKLSHTKVSD........WQVLYKTVYSALGLRDACRS........LPQsiq1 00 410 420 430 440 450 | | | | | | 1 grn14iapLEDINE.HFSNLRILITATVDLSDENTTR..IN........PEFDDELMELEEQRKS 2 i14ksfLKDLTGLK.QMVEQVVDFE--AIERGEYLVK..AS........FDSRLMELQQMMTELY 3 i14ksfLKDLTGLK.QMVEQVVDFE--AIERGEYLVK..AS........FDSRLMELQQMMTELY 4 -----KQMVEQVVD.FE--AIERGEYLVKASFDSRLM..EL........QQMMTELYSKMEELQF 5 PEIVQVFTSFLEdds23shhVEPLSKFEEMVETTVDL..DA........-YEENNEFMIKVEFNE 6 PEIVQVFTSFLEdds23shhVEPLSKFEEMVETTVDL..DA........-YEENNEFMIKVEFNE 7 MVETTVDLD--ALD.NHEFIIKPEFDDSLRIIRKKLD..RL........RTDMDNEFAEAAEDLG 8 AKALPKIVTVLDSL.TSehk17nnhCKNLEKLIELVE..TT........IDLE--ALDSHQYIIR 9 AKALPKIVTVLDSL.TSehk17nnhCKNLEKLIELVE..TT........IDLE--ALDSHQYIIR 10 tdlRSDFSKFQEKI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELREVMDGLEKKM 11 idlRSDFSKFQEMI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELREVMDGLEKKM 12 idlRSDFSKFQEMI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELREVMDGLEKKM 13 tdlRSDFSKFQEMI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELREIMNDLEKKM 14 tdlRSDFSKFQEMI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELREIMNDLEKKM 15 tdlRSDFSKFQEMI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELREIMNDLEKKM 16 tdlRSDFSKFQEMI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELREIMNDLEKKM 17 --------------.----------------------..--........---------------- 18 tdlRSDFSKFQEMI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELK---------- 19 --------------.----------------------..--........---------------- 20 --------------.----------------------..--........---------------- 21 sdlSSDFSKFQEMI.ETTLDMD--QVENHEFLVKASF..DP........NLTELREKMDELEKNM 22 LVETAIDLA--QLE.NGEYRISPLYSSDLGVLKDELS..VV........ENHINNLHVDTASDLD 23 LVECSVDLD--QLE.NGEYMISSSYDTKLASLKDQKE..LL........EQQIHELHKKTAIELD 24 LVECSVDLD--QLE.NGEYMISSNYDTKLASLKDQKE..LL........EQQIHELHKKTAIELD 25 FQVLCDEFFDFDYE.KENKEIRVRVDFVPEIQEISEK..LE........QMERVAEKLRKKYSAK 26 d16kvdISALKECL.RKVETVIDFDT-SRDTKTLTIN..TG........VDNRLDECRNIYNHLE 27 LRKVETVIDFDT-S.RDTKTLTINTGVDNRLDECRNI..YN........HLEGILLDVARETQIF 28 flkDPRFDQIMNIL.VEKVDDSLLdgkknslhLQNTK..CY........AIRHFVAVQLDLARQT 29 RFGIILEKIKTVIN.DDARymkgclnMRTQKCYAVRS..NI........NEFLDIARRTYTEIVD 30 RFGIILEKIKTVIN.DDARymkgclnMRTQKCYAVRS..NI........NEFLDIARRTYTEIVD 31 AIMEIEKLINSCIN.EDCVwassaiqLLNQRSYAVKS..DS........NGLLDVSRQIYKEVKE 32 AIMEIEKLINSCIN.EDCVwassaiqLLNQRSYAVKS..DS........NGLLDVSRQIYKEVKE 33 MHQSYLSehf32ttqLPHFLTMINVSAVMEKNSDKQV..MD........FFNLNNYDCSEGIIKI 34 MHQSYLSehf32ttqLPHFLTMINVSAVMEKNSDKQV..MD........FFNLNNYDCSEGIIKI 35 IIPAVNshi14ile.IPELLSPVEHYLKILNEQAAKV..GD........KTELFKDLSDFPLIKK 36 IIPAVNshi14ile.IPELLSPVEHYLKILNEQAAKV..GD........KTELFKDLSDFPLIKK 37 PAVNshv11ralIV.ELLSPVEHYLKVLNGPAAKVGD..KT........ELFKDLSDFPLIKKRk 38 PAVNshv11ralIV.ELLSPVEHYLKVLNGPAAKVGD..KT........ELFKDLSDFPLIKKRk 39 PAVNshv11ralIV.ELLSPVEHYLKVLNGPAAKVGD..KT........ELFKDLSDFPLIKKRk 40 PAVNshv11ralIV.ELLSPVEHYLKVLNGPAAKVGD..KT........ELFKDLSDFPLIKKRk 41 --------------.----------------------..--........---------------- 42 AILLAGKQIQRLGI.KQDsem28pvvVDNAGKLLSAL..NK........EAAVRGDLL--DILIT 43 --------------.----------------------..--........---------------- 44 VLNFLDEKFIAVME.AILLAGKQIQrlg35pvvVDNA..GK........LLSALNKEAAVRGDLL 45 VLNFLDEKFIAVME.AILLAGKQIQrlg35pvvVDNA..GK........LLSALNKEAAVRGDLL 46 LPSISSIIDHFLGmfDQKEAENNNKVDMFKDIDNFDL..SE........EPNDVDYELAQEIREL 47 LPSISSIIDHFLGmfDQKEAENNNKVDMFKDIDNFDL..SE........EPNDVDYELAQEIREL 48 TLRGCETMAEACSS.LRAILKhdt16gqsLPNISSSI..KY........FKDAFDWVE-AHNSGR 49 TLRGCETMAEACSS.LRAILKhdt41gqsLPNISSSI..KY........FKDAFDWVE-AHNSGR 50 FNDLTKLPTMFHQC.KTtll15ggsFPDLSKELQYFA..TA........FDHDA-AAKTGVIAPQ 51 LEGFKVMCKVSGLL.EEVAGgft21kgrFPDLTAELQ..RW........DTAFDHEK-ARKTGLI 52 LEGFKVMCKVSGLL.EEVAGgft21kgrFPDLTAELQ..RW........DTAFDHEK-ARKTGLI 53 LEGFKVMCKIIGIM.EEVADgfk21egrFPDLTVELN..RW........DTAFDHEK-ARKTGLI 54 LEGFKVMCKIIGIM.EEVADgfk21egrFPDLTVELN..RW........DTAFDHEK-ARKTGLI 55 LEGFKVMCKIIGIM.EEVADgfk21egrFPDLTVELN..RW........DTAFDHEK-ARKTGLI 56 LEGFKVMCKIIGIM.EEVADgfk21egrFPDLTVELN..RW........DTAFDHEK-ARKTGLI 57 LEGFKVMCKIIGIM.EEVADgfk21egrFPDLTVELN..RW........DTAFDHEK-ARKTGLI 58 AIDGFKLCNKLRKE.YIKVQKege17eqeMEEVDENI..YF........FEKMFDRST-AMKDGK 59 QLREEFMeva14iqsAPNMKEELEAWTRAFNWQK-AS..EE........GVFEPEIGFEAEYDTS 60 SKYISSFPEGLVEA.VKswt10rqkAINENIIVPQRG..FD........IEFDKSMDRIQELEDE 61 SKYISSFPEGLVEA.VKswt10rqkAINENIIVPQRG..FD........IEFDKSMDRIQELEDE 62 FDWSD-ADRNGRFI.PYEGCDPEFDATCNAIEEIKSS..LK........EYLKEQRKLLRPASVN 63 --------------.----------------------..--........---------------- 64 PHDELKQLINNAVD.ENALmkqkINEEEETEVIAQEA..EE........ILQDENAQVEIVKKSL 65 PHDELKQLINNAVD.ENALmkqkINEEEETEVIAQEA..EE........ILQDENAQVEIVKKSL 66 9lksqITQLTESLN.FEKNLIDDILKFLNEEELAKSQ..DA........KQNADVTRMLDIDVKD 67 9lksqITQLTESLN.FEKNLIDDILKFLNEEELAKSQ..DA........KQNADVTRMLDIDVKD 68 LIREGYDPDLDALR.AAHREGVAYFLELEERERERTG..IP........TLKVGYNAVFGYYLEV 69 LIREGYDPDLDALR.AAHREGVAYFLELEERERERTG..IP........TLKVGYNAVFGYYLEV 70 LIREGYDPDLDALR.RAHAEGVAYFLDLEAREKERTG..IP........TLKVGYNAVFGYYLEV 71 LIREGYDPDLDALR.RAHAEGVAYFLDLEAREKERTG..IP........TLKVGYNAVFGYYLEV 72 LIREGYDPDLDALR.RAHAEGVAYFLDLEAREKERTG..IP........TLKVGYNAVFGYYLEV 73 VIREGYDPDLDALR.RAHADPVAYFLDLEVREKESTG..IP........TLKVGYNAVFGYYLEV 74 EKTLVEDPPLHVKE.GGLIREGVNAYLDELRFIRDNA..ET........YLREYEKKLRQETGIQ 75 DKTLVDDPPLHVKE.GGLIKPGVNAYLDELRFIRENA..EK........LLKEYEKKLKKETGIQ 76 DPVGSPGEGKVIKR.GFSSELDEYRDLLEHAEERLKE..FE........EKERERTGIQKLRVGY 77 DPVGSPGEGKVIKR.GFSSELDEYRDLLEHAEERLKE..FE........EKERERTGIQKLRVGY 78 IRDGGVLKAGYDNE.LDEMLAISENAGQFLIDLEARE..KA........RTGLANLKVGYNRVHG 79 --------------.----------------------..--........---------------- 80 VLAHIVENPPLHIR.EGNLIRSGVNPTLDEMRQSLED..DN........QWLANLEVTEREKTGI 81 VLAHIVENPPLHIR.EGNLIRSGVNPTLDEMRQSLED..DN........QWLANLEVTEREKTGI 82 ITDGGIIRTGFDET.LDKYRCVLREGTSWIAEIEAKE..RE........NSGISTLKIDYNKKDG 83 LFKVGFNTQLDE--.----------------------..--........---------------- 84 VKEGNLIKDGYNQK.LDEYRDASRNGKDWIARLEQQE..RE........YTGIRSLKVGFNKVFG 85 VKEGNLIKDGYNQK.LDEYRDASRNGKDWIARLEQQE..RE........YTGIRSLKVGFNKVFG 86 VKAVAEQPPLKLTD.GGVIASEYDVELDELRKLSNNA..DQ........FLIDLETRERESSGIS 87 ERAIKENPPVVIRD.GGVIADGYSAELDEWRDLANGA..TE........FLERLEAEERDRHGID 88 WNAPLLTRRRYWSR.RRVIAPGYHEELDEWRALADGA..TD........YLDRLEIRERERTGLD 89 ERAIIDAPPVLVRD.GAVIAPGYHEELDEWRALADGA..TD........YLDRLEIRERERTGLD 90 ERAIIDTPPVLVRD.GGVIASGYNEELDEWRALADGA..TD........YLERLEVRERERTGLD 91 ERAIIDTPPVLVRD.GGVIASGYNEELDEWRALADGA..TD........YLERLEVRERERTGLD 92 ERAIIDTPPVLVRD.GGVIASGYNEELDEWRALADGA..TD........YLERLEVRERERTGLD 93 QRALIETPPLLIRD.GGVIAEGYNAELDEWRMLSDGA..TQ........YLENLEKRERESTGID 94 AKAIIDNPPAVIRD.GGVIKTGYDAELDELQALSENA..GQ........FLMDLEAREKARTGLP 95 AKAIIDNPPAVIRD.GGVIKTGYDAELDELQALSENA..GQ........FLMDLEAREKARTGLP 96 RRAIIDNPPAVIRD.GGVLKQGYDAELDELLSLSENA..GQ........FLMDLEAREKARTGLP 97 QAILPEPSVWLKDG.NVINHGFHPELDELRRIQNHGD..EF........LLDLEAKERERTGLST 98 QAILPEPSVWLKDG.NVINHGFHPELDELRRIQNHGD..EF........LLDLEAKERERTGLST 99 DATLAEELPLLKRD.GGFVREGASAELDEMRALRDQS..RR........VIAGLQLQYCEETGIK 100 HMSIREDAPNNLND.GGIIKYEFHPKIAQLNDLINNK..KL........HVEKLKDQYRKETRIE 101 LEQSIKEDCPVTLS.DGNLIKRGFSASLDELHRVRDN..AN........EILKQYLAEERERTGI 102 LSTDLLQELPLKVS.EGNIFADHYHQDLLRLRNIKTN..SK........SWILEYQERIRQETGI 103 LSTELIQELPLKVS.EGNIFANHYHPDLLRLRNIKEN..SK........SWILEYQERIRNETGI 104 LSKSLNGDLPLRVS.DGNIFVDEFHNDLKRLRHNQEH..SQ........EWIWEYQERIRKETGI 105 LSKSLNGDLPLRVS.DGNIFVDEFHNDLKRLRHNQEH..SQ........EWIWEYQERIRKETGI 106 LINSAISSAPDELI.KRGYDLKLDNLKDLKINANKYI..DQ........YLESERLLSKINNLKI 107 LLYKLCKLPILVGK.SGLELFLSQFEAAID-------..--........---------------- 108 LLYKLCKLPILVGK.SGLELFLSQFEAAID-------..--........---------------- 109 ---KRIKTFIMLIN.GLRNGIDLLNDLQRADHGILA-..--........--LYKIVDIPSLSY-- 110 ---KRIKTFIMLIN.GLRNGIDLLNDLQRADHGILA-..--........--LYKIVDIPSLSY-- 111 EIERIFQVDSLLGD.FKDVIQPIGNLPNLFEQRQTLR..--........-AQLTEWAEQISNIVF 112 vesdLLREVSEIAV.IAGSIINFAESKIQGRVTVMNG..ID........EELDEIRDTYENMPMV 113 vesdLLREVSEIAV.IAGSIINFAESKIQGRVTVMNG..ID........EELDEIRDTYENMPMV 114 NIIRQTPIske9vesdLLREVSEIAVIAGSIINFAES..KI........QGRVTVMNGIDEELDE 115 12qefSDDLHHIAS.LIGKVVDFEE-SLAENRFTVLP..NI........DPDIDAKKRRLIGLPS 116 12qefSDDLHHIAS.LIGKVVDFEE-SLAENRFTVLP..NI........DPDIDAKKRRLIGLPS 117 2qefSDDLHHIASL.IGKVVDFEG-SLAENRFTVLPN..ID........PEIDEKKRRLMGLPSF 118 2qefSDDLHHIASL.IGKVVDFEG-SLAENRFTVLPN..ID........PEIDEKKRRLMGLPSF 119 2qefSDDLHHIASL.IGKVVDFEG-SLAENRFTVLPN..ID........PEIDEKKRRLMGLPSF 460 470 480 490 500 | | | | | 1 VVKAI....ES....EHQR......VMKVYGWTek..QLKCEYHTTYGYVFRVTRKEDQQVRTSk 2 SKMEE....LQ....FKCS......QELNLDgkn...QVKLESVAKLGHHFRITVKDDSVLRKNk 3 SKMEE....LQ....FKCS......QELNLDgkn...QVKLESVAKLGHHFRITVKDDSVLRKNk 4 KCSQE....LN....LDgkn.....QVKLESVAK...LGHHFRITVKDDSVLRKNknYRIVDVIK 5 ELGKI....RS....KLDT......LRDEIHSIH...LDSAEDLGFDpdkKLKLENHHLHGWCMR 6 ELGKI....RS....KLDT......LRDEIHSIH...LDSAEDLGFDpdkKLKLENHHLHGWCMR 7 QErek....KI....FLEN......HKVHGWCMR...LTRTEAGCIRNNsrYLECSTQKNGVYFT 8 AEFDE....EL....LDLR......QRLDELQHS...IFEEHKRVGSDLHQDtekKLHLEQHHLY 9 AEFDE....EL....LDLR......QRLDELQHS...IFEEHKRVGSDLHQDtekKLHLEQHHLY 10 QSTLI....SA....ARGL......GLDpgkQIK...LDSSAQFGYYFRVTCKEEKVLRNNknFS 11 QSTLI....NA....ARGL......GLDpgkQIK...LDSSAQFGYYFRVTCKEEKVLRNNknFS 12 QSTLI....NA....ARGL......GLDpgkQIK...LDSSAQFGYYFRVTCKEEKVLRNNknFS 13 QSTLI....SA....ARDL......GLDpgkQIK...LDSSAQFGYYFRVTCKEEKVLRNNknFS 14 QSTLI....SA....ARDL......GLDpgkQIK...LDSSAQFGYYFRVTCKEEKVLRNNknFS 15 QSTLI....SA....ARDL......GLDpgkQIK...LDSSAQFGYYFRVTCKE----------- 16 QSTLI....SA....ARDL......GLDpgkQIK...LDSSAQFGYYFRVTCKEEKVLRNNknFS 17 -----....--....----......---------...---------------------------- 18 -----....--....----......---------...---------------------------- 19 -----....--....----......---------...---------------------------- 20 -----....--....----......---------...---------------------------- 21 QGALG....GA....AREL......GLDagkSIK...LESNSQIGHYFRVTCKEEKALRNNkkFT 22 LSvdk....QL....KLEK......-GSLGHVFR...MSKKEEQKVRKKltgsYLIIETRKDGVK 23 LQvdk....AL....KLDK......AAQFGHVFR...ITKKEEPKIRKKlttqFIVLETRKDGVK 24 LQvdk....AL....KLDK......AAQFGHVFR...ITKKEEPKIRKKlttqFIVLETRKDGVK 25 FECDN....LK....LDKN......SQYGFYFRV...TLKEEKSIRKKdvHILETTKGSGVKFSV 26 GILLD....VA....RETQ......IFLLNTmpq...14lekLVNAVYIPQLGYLVTISVLMEPL 27 LLNTmpq..14lek.LVNA......VYIPQLGYL...VTISVLMEPLldgIPNLqWEEIFRSSEN 28 YEEII....RN....VEET......GAREIAEYF...HGnsSVRLSFSQSRGFHYTFVTRQAESv 29 DIAGM....IS....QLGE......KYSLP-LRT...SFSSARGFFIQMTTDCIalpsDQLPSEF 30 DIAGM....IS....QLGE......KYSLP-LRT...SLSSVRGFFIQMTTDCIalpsDQLPSEF 31 EFFRE....VE....DLTA......KNKIN-LDH...NYDSARGFYLRIKRQEFTDdvatLPDVF 32 EFFRE....VE....DLTA......KNKIN-LDH...NYDSARGFYLRIKRQEFTDdvatLPDVF 33 QRESE....SV....RSQL......KEELAEIRK...YLKRPYLNFR--DEVDYLIEVKNSQIKD 34 QRESE....SV....RSQL......KEELAEIRK...YLKRPYLNFR--DEVDYLIEVKNSQIKD 35 RkDEI....QG....VIDE......IRMHLQEIR...KILKNPSAQYVTVSGQEFMIEIKNSAVS 36 RkDEI....QG....VIDE......IRMHLQEIR...KILKNPSAQYVTVSGQEFMIEIKNSAVS 37 NEIQE....VI....HSIQ......MRLQEFRKI...LKLPSLQYVTVSGQEFMIEIKNSAVSCI 38 NEIQE....VI....HSIQ......MRLQEFRKI...LKLPSLQYVTVSGQEFMIEIKNSAVSCI 39 NEIQE....VI....HSIQ......MRLQEFRKI...LKLPSLQYVTVSGQEFMIEIKNSAVSCI 40 NEIQE....VI....HSIQ......MRLQEFRKI...LKLPSLQYVTVSGQEFMIEIKNSAVSCI 41 -----....--....----......---------...---------------------------- 42 SSDQF....PE....LAEA......RQAVLVIRE...KLDSSIASFRKKLAIRNLEFLQVSGITH 43 -----....--....----......---------...---------------------------- 44 --DIL....IT....SSDQ......FPELAEARQ...AVLVIREKLDSSIASFRKKLAIRNLEFL 45 --DIL....IT....SSDQ......FPELAEARQ...AVLVIREKLDSSIASFRKKLAIRNLEFL 46 KMSIL....MV....RTEM......DFHLQELRD...YLEYPNLEFSIWGNVKFCIEVSKGC-KK 47 KMSIL....MV....RTEM......DFHLQELRD...YLEYPNLEFSIWGNVKFCIEVSKGC-KK 48 VIPHE....GA....DEEY......DCACKTVEE...FESSLKKHLKEQRKLLGDASINYVTVGK 49 VIPHE....GA....DEEY......DCACKTVEE...FESSLKKHLKEQRKLLGDASINYVTVGK 50 AGMDA....EY....DAAM......DSIGEVEKR...LKTYLVEQERHFGCR-ITYFGSDKKRYQ 51 TPKAG....FD....SDYD......QALADIREN...EQSLLEYLDKQRSRLGCKSIVYWGIGRN 52 TPKAG....FD....SDYD......QALADIREN...EQSLLEYLDKQRSRLGCKSIVYWGIGRN 53 TPKAG....FD....SDYD......QALADIREN...EQSLLEYLEKQRNRIGCRTIVYWGIGRN 54 TPKAG....FD....SDYD......QALADIREN...EQSLLEYLEKQRNRIGCRTIVYWGIGRN 55 TPKAG....FD....SDYD......QALADIREN...EQSLLEYLEKQRNRIGCRTIVYWGIGRN 56 TPKAG....FD....SDYD......QALADIREN...EQSLLEYLEKQRNRIGCRTIVYWGIGRN 57 TPKAG....FD....SDYD......QALADIREN...EQSLLEYLEKQRNRIGCRTIVYWGIGRN 58 IVPNA....GC....DEEY......DEALNRVKE...ALNELNDYKDSVAKKYSCS-IKFVDSGK 59 QKYQS....EL....KNEL......YALLEQYKK...QLRCSSLNFKNIGKEVYQVEVPSDV--K 60 LMEIL....MT....YRKQ......FKCSNIQYK...DSGKEIYTIEIPISATKNVPSNWVQMAA 61 LMEIL....MT....YRKQ......FKCSNIQYK...DSGKEIYTIEIPISATKNVPSNWVQMAA 62 YVNVG....KD....MYLI......EVPESLGGS...VPRNYELQSTKKGFYRYWTPELKELILE 63 -----....--....----......---------...---------------------------- 64 SSEFD....IR....QSFK......EN-------...--------------------WVVKSNFN 65 SSEFD....IR....QSFK......EN-------...--------------------WVVKSNFN 66 KKESN....KD....EIFE......L--------...---------------------------- 67 KKESN....KD....EIFE......L--------...---------------------------- 68 TRPYY....ER....VPKE......YRPVQTLKD...RQRYTLPEMKEKEREVYRLEALIRRREE 69 TRPYY....ER....VPKE......YRPVQTLKD...RQRYTLPEMKEKEREVYRLEALIRRREE 70 TRPYY....EK....VPQE......YRPVQTLKD...RQRYTLPEMKERERELYRLEALIKRREE 71 TRPYY....EK....VPQE......YRPVQTLKD...RQRYTLPEMKERERELYRLEALIKRREE 72 TRPYY....EK....VPQE......YRPVQTLKD...RQRYTLPEMKERERELYRLEALIKRREE 73 TRPYY....EK....VPQE......YRPVQTLKD...RQRYTLPEMKERERELYRLEALIKRREE 74 SLKIG....YN....KVMG......YYIEVTKPN...LKYVPSYFRRRQTLSNSERFTTEELQRL 75 SLKIG....YN....KVMG......YYIEVTKAN...VKYVPEHFRRRQTLSNAERYTTEELQRL 76 NQVFG....YY....IEVT......KANLDKIPD...DYERKQTLVNSERFITPELKEFETKIMA 77 NQVFG....YY....IEVT......KANLDKIPD...DYERKQTLVNSERFITPELKEFETKIMA 78 YFIEL....PT....KQAE......QAPGDYIRR...QTLKGAERFITPELKAFEDKALSAKSRA 79 -----....--....----......---------...---------------------------- 80 ANLKV....GY....NKAF......GYYLSLPRS...KSEQAPDNYIRKQTLVNEERYITPELKE 81 ANLKV....GY....NKAF......GYYLSLPRS...KSEQAPDNYIRKQTLVNEERYITPELKE 82 YYFHV....TN....SQLG......NVPAHFFRK...ATLKNSERFGTEELARIEGDMLEAREKS 83 -----....--....----......---------...---------------------------- 84 YYIEV....TK....ANLH......LLEEGrYER...NETLTNAERYITPELKEKEALILEAENN 85 YYIEV....TK....ANLH......LLEEGrYER...NETLTNAERYITPELKEKEALILEAENN 86 TLKVG....YN....RVHG......YYIEISKGQ...ADKAPVHYTRRQTLTNAERYITEELKAF 87 TLKVG....YN....NVHG......FYIQVSRGQ...SHLVPPHYVRRQTLKNAERYIIEELKQH 88 TLKVG....YN....AVHG......YYIQISRGQ...SHLAPINYVRRQTLKNAERYIIPELKEY 89 TLKVG....YN....AVHG......YYIQISRGQ...SHLAPINYVRRQTLKNAERYIIPELKEY 90 TLKVG....FN....AVHG......YYIQISRGQ...SHLAPINYMRRQTLKNAERYIIPELKEY 91 TLKVG....FN....AVHG......YYIQISRGQ...SHLAPINYMRRQTLKNAERYIIPELKEY 92 TLKVG....FN....AVHG......YYIQISRGQ...SHLAPINYMRRQTLKNAERYIIPELKEY 93 TLKIG....FN....AVHG......YYIQISQGQ...AHKAPIHYVRRQTLKNAERYIIPELKEY 94 NLKVG....YN....RIHG......YFIELPRVQ...AEQAPADYIRRQTLKGAERFITPELKAF 95 NLKVG....YN....RIHG......YFIELPRVQ...AEQAPADYIRRQTLKGAERFITPELKAF 96 NLKVG....YN....RIHG......YYIELPRVQ...AEQAPADYIRRQTLKGAERFITPELKAF 97 LKVEF....NR....VHGF......YIELSKTQA...EQAPADYQRRQTLKNAERFITPELKAFE 98 LKVEF....NR....VHGF......YIELSKTQA...EQAPADYQRRQTLKNAERFITPELKAFE 99 SLKIK....HN....NVLG......YFIEVTAGN...AGSMTDTdagrarFIHRQTMANAMRFTT 100 SLKIS....HN....NVLG......FFIDITPKN...VNKiLDPKFIHRQTTINSVRYTTYELQN 101 GTLKM....KY....NRML......GHFLEVSKG...HLSAVPAHFIRRRSLSNADRFTTEQLSE 102 KKLKV....CY....AQAL......GYYIEVASS...FAPQLPKEFIRRQSRLHAERFTTQELQQ 103 KKLKV....CY....AQAL......GYYIEVASN...LAPQLPKEFIRRQSRLHAERFTTQELQQ 104 KKLKI....CF....AQAL......GYYIEVSSE...FAPQLPKDFIRRQSRLHAERFTTIELQQ 105 KKLKI....CF....AQAL......GYYIEVSSE...FAPQLPKDFIRRQSRLHAERFTTIELQQ 106 RKTNN....RG....LFFE......VTKSNYAQV...PPHFMESQALNSSKRYKTEKLISLEVDI 107 -----....--....----......---------...---------------------------- 108 -----....--....----......---------...---------------------------- 109 -----....--....----......---------...---------------------------- 110 -----....--....----......---------...---------------------------- 111 QDttS....IK....AEYF......NKEGYAFSI...SSKKLTKLEHYMMNTSISNN-------- 112 LTAIA....KQ....EEAR......LGLPpysNV...ACVYIPLVGFVLSVPRDY---------- 113 LTAIA....KQ....EEAR......LGLPpysNV...ACVYIPLVGFVLSVPRDY---------- 114 IRDTY....EN....MPMV......LTAIAKQEE...ARLGLPpysNVACVYIPLVGFVLSVPRD 115 FLTEV....AQ....KELE......NLDsrIPSC...SVIYIPLIGFLLSIPR------------ 116 FLTEV....AQ....KELE......NLDsrIPSC...SVIYIPLIGFLLSIPR------------ 117 LTEVA....RK....ELEN......LDsrIPSCS...VIYIPLIGFLLSIPR------------- 118 LTEVA....RK....ELEN......LDsrIPSCS...VIYIPLIGFLLSIPR------------- 119 LTEVA....RK....ELEN......LDsrIPSCS...VIYIPLIGFLLSIPR-------------