; SAM: prettyalign v3.2 (July 31, 2000) compiled 07/31/00_16:52:38 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequences correspond to the following labels: ; 1 T0116-1-500 ; 2 gi|2497995|sp|Q56215|MUTS_THEAQ_3:500 ; 3 gi|4887554|emb|CAB43497.1|_6:524 ; 4 gi|127556|sp|P23909|MUTS_ECOLI_6:524 ; 5 gi|1592569|gb|AAB97931.1|_6:524 ; 6 gi|2497996|sp|Q56239|MUTS_THETH_10:508 ; 7 gi|1871501|dbj|BAA09880.1|_10:508 ; 8 gi|1171081|sp|P44834|MUTS_HAEIN_3:526 ; 9 gi|127555|sp|P27345|MUTS_AZOVI_3:523 ; 10 gi|7229490|gb|AAF42850.1|_4:523 ; 11 gi|7108493|gb|AAF36440.1|AF126491_1_4:523 ; 12 gi|9654962|gb|AAF93703.1|_7:531 ; 13 gi|2145507|pir||S62790_18:507 ; 14 gi|417330|sp|P10339|MUTS_SALTY_7:525 ; 15 gi|7387928|sp|Q9ZIX6|MUTS_THECA_8:506 ; 16 gi|1619909|gb|AAB16999.1|_3:501 ; 17 gi|7448104|pir||I64827_19:575 ; 18 gi|2135744|pir||I37550_19:575 ; 19 gi|4557761|ref|NP_000242.1|_19:575 ; 20 gi|6226653|sp|P74926|MUTS_THEMA_3:501 ; 21 gi|7404405|sp|P73769|MUTS_SYNY3_22:561 ; 22 gi|7448108|pir||S74860_56:595 ; 23 gi|6678938|ref|NP_032654.1|_19:575 ; 24 gi|726086|gb|AAA75027.1|_19:575 ; 25 gi|7512474|pir||JC5839_394:1024 ; 26 gi|4504191|ref|NP_000170.1|_394:1024 ; 27 gi|1082386|pir||A56742_326:956 ; 28 gi|1709123|sp|P52701|MSH6_HUMAN_394:1024 ; 29 gi|79102|pir||A28668_7:524 ; 30 gi|6754744|ref|NP_034960.1|_393:1021 ; 31 gi|1709122|sp|P54275|MSH2_RAT_19:575 ; 32 gi|7512473|pir||JC5840_394:1024 ; 33 gi|2506881|sp|P54276|MSH6_MOUSE_393:1021 ; 34 gi|123080|sp|P10564|HEXA_STRPN_4:509 ; 35 gi|7387913|sp|O84797|MUTS_CHLTR_4:526 ; 36 gi|7227419|gb|AAF42468.1|_4:518 ; 37 gi|7404403|sp|P49849|MUTS_BACSU_3:512 ; 38 gi|7379009|emb|CAB83555.1|_4:518 ; 39 gi|9106782|gb|AAF84525.1|AE003995_7_39:565 ; 40 gi|7189834|gb|AAF38705.1|_5:532 ; 41 gi|387849|gb|AAB60711.1|_175:753 ; 42 gi|400971|sp|P13705|MSH3_MOUSE_175:753 ; 43 gi|1083296|pir||JC4019_189:788 ; 44 gi|3024198|sp|P70755|MUTS_AQUPY_6:518 ; 45 gi|1002520|gb|AAB19235.1|_1:506 ; 46 gi|7387924|sp|Q9Z6W5|MUTS_CHLPN_5:532 ; 47 gi|7190210|gb|AAF39048.1|_4:526 ; 48 gi|1079288|pir||S53609_19:573 ; 49 gi|3914079|sp|O66652|MUTS_AQUAE_4:518 ; 50 gi|6320302|ref|NP_010382.1|_299:877 ; 51 gi|1588283|prf||2208298A_299:877 ; 52 gi|1000883|gb|AAB59571.1|_19:529 ; 53 gi|110917|pir||A32495_175:753 ; 54 gi|6647605|sp|Q9ZDM9|MUTS_RICPR_13:553 ; 55 gi|7492209|pir||T41262_362:924 ; 56 gi|6093453|sp|O83348|MUTS_TREPA_5:530 ; 57 gi|6226648|sp|O04716|MSH6_ARATH_367:977 ; 58 gi|8473172|sp|P56883|MUTS_RHIME_21:566 ; 59 gi|2104549|gb|AAB57798.1|_372:1015 ; 60 gi|4505249|ref|NP_002430.1|_211:789 ; 61 gi|1000879|gb|AAB59570.1|_19:482 ; 62 gi|4139230|gb|AAD04176.1|_27:571 ; 63 gi|118951|sp|P20585|MSH3_HUMAN_220:798 ; 64 gi|3914075|sp|O51737|MUTS_BORBU_4:516 ; 65 gi|7331984|gb|AAF60672.1|_840:1459 ; 66 gi|7328284|emb|CAB82466.1|_2:419 ; 67 gi|1174416|sp|P43248|MSH2_DROME_8:567 ; 68 gi|3914053|sp|O13396|MSH2_NEUCR_14:562 ; 69 gi|7287834|gb|AAF44872.1|AE003406_77_24:571 ; 70 gi|1076927|pir||S22569_4:572 ; 71 gi|135075|sp|P26359|SWI4_SCHPO_94:664 ; 72 gi|7294307|gb|AAF49656.1|_249:858 ; 73 gi|6319935|ref|NP_010016.1|_152:725 ; 74 gi|3319876|emb|CAA07684.1|_93:712 ; 75 gi|3914056|sp|O24617|MSH2_ARATH_27:571 ; 76 gi|448278|prf||1916402A_152:724 ; 77 gi|6324482|ref|NP_014551.1|_19:592 ; 78 gi|172002|gb|AAA34802.1|_19:592 ; 79 gi|1000877|gb|AAB59569.1|_19:423 ; 80 gi|6166561|sp|O13921|MSH1_SCHPO_50:578 ; 81 gi|6224917|gb|AAF06013.1|AF193018_1_255:726 ; 82 gi|7298155|gb|AAF53392.1|_24:508 ; 83 gi|4775576|emb|CAB42554.1|_29:572 ; 84 gi|9294039|dbj|BAB01996.1|_255:726 ; 85 gi|4151103|emb|CAA07342.1|_20:587 ; 86 gi|7522263|pir||T39832_20:579 ; 87 gi|7269404|emb|CAB81364.1|_93:725 ; 88 gi|4775578|emb|CAB42555.1|_353:805 ; 89 gi|4775580|emb|CAB42556.1|_46:498 ; 90 gi|3914062|sp|O65607|MSH3_ARATH_93:725 ; 91 gi|172000|gb|AAA34801.1|_68:557 ; 92 gi|1000875|gb|AAB59568.1|_19:377 ; 93 gi|6321912|ref|NP_011988.1|_68:557 ; 94 gi|3886083|gb|AAC78226.1|_18:547 ; 95 gi|9864530|gb|AAG00261.1|_10:607 ; 96 gi|1000873|gb|AAB59567.1|_19:338 ; 97 gi|3986757|gb|AAC84154.1|_15:450 ; 98 gi|7305281|ref|NP_038628.1|_15:450 ; 99 gi|7522430|pir||T38256_2:417 ; 100 gi|8515837|gb|AAF76200.1|_58:505 ; 101 gi|3831701|gb|AAC70065.1|_58:505 ; 102 gi|4336728|gb|AAD17920.1|_148:585 ; 103 gi|4505253|ref|NP_002432.1|_44:451 ; 104 gi|4505251|ref|NP_002431.1|_148:585 ; 105 gi|3108220|gb|AAC62533.1|_44:451 ; 106 gi|5725250|emb|CAB52406.1|_44:468 ; 107 gi|6321109|ref|NP_011187.1|_97:543 ; 108 gi|730066|sp|P40965|MSH4_YEAST_97:543 ; 109 gi|3914066|sp|Q19272|MSH5_CAEEL_58:606 ; 110 gi|3914061|sp|O63852|MSHM_SARGL_71:565 ; 111 gi|5815430|gb|AAD52669.1|AF178755_1_50:495 ; 112 gi|7012942|gb|AAF35250.1|AF227632_1_1:276 ; 113 gi|6981224|ref|NP_034959.1|_143:376 ; 114 gi|7243293|dbj|BAA92687.1|_38:229 ; 115 gi|7547005|gb|AAF63754.1|AF242852_1_65:256 ; 116 gi|6320047|ref|NP_010127.1|_53:531 ; 117 gi|1582703|prf||2119252A_48:531 ; 118 gi|2072992|gb|AAC46142.1|_1:130 ; 119 gi|7490460|pir||T37626_49:190 10 20 30 40 50 | | | | | 1 MEGMLKGEGPGPLPPL........LQQYVELRDQYPDYLLLFQVGD....FYECFG.EDAERLAR 2 --GMLKGEGPGPLPPL........LQQYVELRDQYPDYLLLFQVGD....FYECFG.EDAERLAR 3 --------NFDAHTPM........MQQYLKLKAQHPEILLFYRMGD....FYELFY.DDAKRASQ 4 --------NFDAHTPM........MQQYLRLKAQHPEILLFYRMGD....FYELFY.DDAKRASQ 5 --------NFDAHTPM........MQQYLKLKAQHPEILLFYRMGD....FYELFY.DDAKRASQ 6 -EGMLKGEGPGPLPPL........LQQYVELRDRYPDYLLLFQVGD....FYECFG.EDAERLAR 7 -EGMLKGEGPGPLPPL........LQQYVELRDRYPDYLLLFQVGD....FYECFG.EDAERLAR 8 -----SEENFQQHTPM........MQQYLKLKAENPDILLFYRMGD....FYELFY.DDAKKAAA 9 --------SLSQHTPM........MQQYWKLKREHPDQLMFYRMGD....FYELFY.EDAKKAAK 10 ---------LSQHTPM........MQQYFKLKHQHPDQLMFYRMGD....FYELFY.EDAKKAAK 11 ---------LSQHTPM........MQQYFKLKHQHPDQLMFYRMGD....FYELFY.EDAKKAAK 12 ----SPSESLSHHTPM........MQQYLRLKAENPDILLFYRMGD....FYELFY.DDAKRASE 13 ----------PPLPPL........LQQYVELRDRYPDYLLLFQVGD....FYECFG.EDAERLAR 14 -------KDFSNHTPM........MQQYLKLKAQHPEILLFYRMGD....FYELFY.DDAKRASQ 15 --VMLKGEGPGPLPPL........LQQYVELRDRYPDYLLLFQVGD....FYECFG.EDAERLAR 16 ------------VTPL........MEQYLRIKEQYKDSILLFRLGD....FYEAFF.EDAKIVSK 17 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 18 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 19 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 20 ------------VTPL........MEQYLRIKEQYKDSILLFRLGD....FYEAFF.EDAKIVSK 21 ---------RQKLTPM........FQHYTEVKEQYQGALLLYRVGD....FFECFF.QDAVIIAR 22 ---------RQKLTPM........FQHYTEVKEQYQGALLLYRVGD....FFECFF.QDAVIIAR 23 ---------------F........VRFFEGMPEKPSTTVRLFDRGD....FYTAHG.EDALLAAR 24 ---------------F........VRFFEGMPEKPSTTVRLFDRGD....FYTAHG.EDALLAAR 25 STLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVGK....FYELYH.MDALIGVS 26 STLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVGK....FYELYH.MDALIGVS 27 STLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVGK....FYELYH.MDALIGVS 28 STLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVGK....FYELYH.MDALIGVS 29 -------KDFSNHTPM........MQQYLKLKAQHPEILLFYRMGD....FYELFY.DDAKRASQ 30 TTLYVPEEFLNSCTPG........MRKWWQLKSQNFDLVIFYKVGK....FYELYH.MDAVIGVS 31 ---------------F........VRFFEGMPEKPSTTVGLFDRGD....FYTAHG.EDALLAAR 32 STLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVGK....FYELYH.MDALIGVS 33 TTLYVPEEFLNSCTPG........MRKWWQLKSQNFDLVIFYKVGK....FYELYH.MDAVIGVS 34 ----------EKLSPG........MQQYVDIKKQYPDAFLLFRMGD....FYELFY.EDAVNAAQ 35 -----------KLTPM........MQQWHQCKEQAGDCLLLFRLGE....FYEAFF.DDALILAQ 36 ----------SAVSPM........MQQYLGIKAQHTDKLVFYRMGD....FYEMFF.DDAVEAAK 37 -----------GYTPM........IQQYLKIKAEHQDAFLFFRLGD....FYEMFF.EDAKKASQ 38 ----------SAVSPM........MQQYLGIKAQHTDKLVFYRMGD....FYEMFF.DDAVEAAK 39 --KPEGGKGMAEHTPL........MKQYFAAKAEYPDLLLFFRMGD....FYELFH.QDARKAAR 40 -----------KPTPM........MEQWHQCKEKAGDSVLLFRMGD....FYEAFY.DDAVLLSQ 41 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECGY....KYRFFG.EDAEIAAR 42 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECGY....KYRFFG.EDAEIAAR 43 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECGY....KYRFFG.EDAEIAAR 44 ----------KELTPM........LAQYHQFKSMYPDCLLLFRLGD....FYELFY.EDAVVGSK 45 ---------------M........IQQYLKIKAEHQDAFLFFRLGD....FYEMFF.EDAKKASQ 46 -----------KPTPM........MEQWHQCKEKAGDSVLLFRMGD....FYEAFY.DDAVLLSQ 47 -----------KLTPM........MQQWHQCKEQAGDCLLLFRLGE....FYEAFF.DDALVLAQ 48 ---------------F........LHFYQSMPEKPDTTVRVFDRND....YYTVHG.GDALFAAK 49 --------SEKELTPM........LSQYHYFKNQYPDCLLLFRLGD....FYELFY.EDAYIGSK 50 RTLYIPSSAWNKFTPF........EKQYWEIKSKMWDCIVFFKKGK....FFELYE.KDALLANA 51 RTLYIPSSAWNKFTPF........EKQYWEIKSKMWDCIVFFKKGK....EFELYE.KDALLANA 52 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 53 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECGY....KYRFFG.EDAEIAAR 54 -----QKYNYNVATKM........MQQYLDIKFAHLDCLLLFRMGD....FYELFY.EDAILASN 55 RTLYIPPSAWATFKPF........EKQFWKIKKDLMDTVVFFQKGK....FYELYE.NDAAIGHQ 56 ----------ASDTPL........MRQYHAIRAQHPDAVLFFRLGD....FYEMFD.SDALHVST 57 RTLYLPPDFVKKLTGG........QRQWWEFKAKHMDKVVFFKMGK....FYELFE.MDAHVGAK 58 ----ASEESRSTATPM........MEQFIEIKANNPDSLLFYRMGD....FYELFF.QDAVEASR 59 RTLYLPPDFVKKLTGGqvrrahgnLRQWWEFKAKHMDKVVFFKMGK....FYELFE.MDAHVGAK 60 ---SANKRSKSIYTPL........ELQYIEMKQQHKDAVLCVECGY....KYRFFG.EDAEIAAR 61 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 62 ----------------........---FYKTLPNDTRAVRFFDRKD....YYTAHG.ENSVFIAK 63 ---SANKRSKSIYTPL........ELQYIEMKQQHKDAVLCVECGY....KYRFFG.EDAEIAAR 64 -----------NVTPM........IRQYLDIKKKYKDAVLFFRVGS....FYEMFF.DDAIEVSK 65 KTLWVPPDFHQKQTPG........HRQWWTMKSQHFDTILLFKVGK....FYETYH.MDAVEVVR 66 ----------SNVTPM........MQQYLKIKSEYQDCLLFFRLGD....FYEMFY.EDAKEASR 67 ---TYPEYGHKCASNF........IKFHAKLGEKPATTVRFFDHTD....RYTVHGsDDCELVAK 68 --------------GF........IRFYKSLPQLGEEAIRIFDRGD....WYTAHG.DDATFIAR 69 ---------------F........IKFHAKLGEKPATTVRFFDHTD....RYTVHGsDDCELVAK 70 -----PTKQKSVFTPL........EQQYLELKKNYQETILAIEVGY....KFRFFG.KDAKIASE 71 ---SKPTKQKSVFTPL........EQQYLELKKNYQETILAIEVGY....KFRFFG.KDAKIASE 72 STLHVPEKFLNGLSPG........VRQWWVLKSDNYDCVLFFKVGK....FYELYH.MDADVGVN 73 ---KARKSPTAKLTPL........DKQVKDLKMHHRDKVLVIRVGY....KYKCFA.EDAVTVSR 74 -EYVPETSSSRKYTPL........EQQVVELKSKYPDVVLMVEVGY....RYRFFG.EDAEIAAR 75 ----------------........---FYKTLPNDTRAVRFFDRKD....YYTAHG.ENSVFIAK 76 ---KARKSPTAKLTPL........DKQVKDLKMHHRDKVLVIRVGY....KY-CFA.EDAVTVSR 77 ---------------F........YKKYTGLPKKPLKTIRLVDKGD....YYTVIG.SDAIFVAD 78 ---------------F........YKKYTGLPKKPLKTIRLVDKGD....YYTVIG.SDAIFVAD 79 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 80 --DFIRPKEKVTLPPL........LKEVSFQQKKFADCVLLTKVGN....FYEMYF.EQAEKIGP 81 KTLHIPPDVFKKMSAS........QKQYWSVKSEYMDIVLFFKVGK....FYELYE.LDAELGHK 82 ---------------F........IKFHAKLGEKPATTVRFFDHTD....RYTVHGsDDCELVAK 83 ----------------........---FFKKLPQDPRAVRLFDRRD....YYTAHG.ENATFIAR 84 KTLHIPPDVFKKMSAS........QKQYWSVKSEYMDIVLFFKVGK....FYELYE.LDAELGHK 85 ----------------........--NFYEKMPKDTNTVRVFDRGE....FYVAIG.EDASFVAQ 86 ----------------........--NFYEKMPKDTNTVRVFDRGE....FYVAIG.EDASFVAQ 87 -EYVPETSSSRKYTPL........EQQVVELKSKYPDVVLMVEVGY....RYRFFG.EDAEIAAR 88 STLFIPPDALRKMSTS........QKQYWNIKCKYMDVVLFFKVGK....FYELYE.LDAEIGQK 89 STLFIPPDALRKMSTS........QKQYWNIKCKYMDVVLFFKVGK....FYELYE.LDAEIGQK 90 -EYVPETSSSRKYTPL........EQQVVELKSKYPDVVLMVEVGY....RYRFFG.EDAEIAAR 91 -KLSSTEPSKASLPPS........LQYVRDLMDLYKDHVVLTQMGS....FYELYF.EQAIRYAP 92 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 93 -KLSSTEPSKASLPPS........LQYVRDLMDLYKDHVVLTQMGS....FYELYF.EQAIRYAP 94 ----------------........-------KSKSPNTIAIFSRGE....YFSVYG.DDATFVAT 95 ----------------........LQAFTAVGGDDKACVRLFSRGGstpgCYVLGS.WAGFIARE 96 ---------------F........VRFFQGMPEKPTTTVRLFDRGD....FYTAHG.EDALLAAR 97 ----------------........----------------------....------.-------- 98 ----------------........----------------------....------.-------- 99 ----------------........----------------------....------.-------- 100 ----------------........----------------------....------.-------- 101 ----------------........----------------------....------.-------- 102 ----------------........----------------------....------.-------- 103 ----------------........----------------------....------.-------- 104 ----------------........----------------------....------.-------- 105 ----------------........----------------------....------.-------- 106 ----------------........----------------------....------.-------- 107 ----------------........----------------------....------.-------- 108 ----------------........----------------------....------.-------- 109 ----------------........----------------------....------.-------- 110 ----------------........----------------------....------.---EQVAS 111 ----------------........----------------------....------.-------- 112 ----------------........----------------------....------.-------- 113 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECGY....KYRFFG.EDAEIAAR 114 ----------------........----------------------....------.-------- 115 -----------KYTPL........EQQVVELKRKHPDVILMVEVGY....RYRFFG.EDAEIAAR 116 ----------------........----------------------....------.-------- 117 ----------------........----------------------....------.-------- 118 ----------------........----------------------....---CFF.QDAIVVAR 119 -LDFIRPKEKVTLPPL........LKEVSFQQKKFADCVLLTKVGN....FYEMYF.EQAEKIGP 60 70 80 90 1 | | | | 1 ALGL......VLTHK........TSK..DFTTPMAGIPLRAFEAYAE.RLL..KMGFRLAVADQV 2 ALGL......VLTHK........TSK..DFTTPMAGIPLRAFEAYAE.RLL..KMGFRLAVADQV 3 LLDI......SLTKR........GASa.GEPIPMAGIPYHAVENYLA.KLV..NQGESVAICEQI 4 LLDI......SLTKR........GASa.GEPIPMAGIPYHAVENYLA.KLV..NQGESVAICEQI 5 LLDI......SLTKR........SASa.GEPIPMAGIPYHAVENYLA.KLV..NQGESVAICEQI 6 ALGL......VLTHK........TSK..DFTTPMAGIPIRAFDAYAE.RLL..KMGFRLAVADQV 7 ALGL......VLTHK........TSK..DFTTPMAGIPIRAFDAYAE.RLL..KMGFRLAVADQV 8 LLDI......SLTKR........GQSa.GQPIPMAGMPYHAVEGYLA.KLV..QLGESVAICEQI 9 LLDI......TLTAR........GQSa.GKSIPMAGIPFHSVEGYLA.KLV..KLGESVAICEQI 10 LLDI......TLTAR........GQSg.GKAIPMAGIPFHSAEGYLA.KLV..KLGESVAICEQI 11 LLDI......TLTAR........GQSg.GKAIPMAGIPFHSAEGYLA.KLV..KLGESVAICEQI 12 LLDI......SLTKR........GASa.GEPIPMAGVPFHAVEGYLA.KLV..QMGESVAICEQI 13 ALGL......VLTHK........TSK..DFTTPMAGIPIRAFDAYAE.RLL..KMGFRLAVADQV 14 LLDI......SLTKR........GASa.GEPIPMAGIPHHAVENYLA.KLV..NQGESVAICEQI 15 ALGL......VLTHK........TSK..DFTTPMAGIPIRAFDAYAE.RLL..RMGFGLAVADQV 16 VLNI......VLTRR........---..-QDAPMAGIPYHALNTYLK.KLV..EAGYKVAICDQM 17 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 18 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 19 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 20 VLNI......VLTRR........---..-QDAPMAGIPYHALNTYLK.KLV..EAGYKVAICDQM 21 ELEL......ILTSK........EGGkeIGRVAMTGVPHHALDRYAR.QLV..EKGYAVAICDQV 22 ELEL......ILTSK........EGGkeIGRVAMTGVPHHALDRYAR.QLV..EKGYAVAICDQV 23 EVFK......TQGVIkymg....PAG..SKTLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNK 24 EVFK......TQGVIkymg....PAG..SKTLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNK 25 ELGL......VFMKG........---..--NWAHSGFPEIAFGRYSD.SLV..QKGYKVARVEQT 26 ELGL......VFMKG........---..--NWAHSGFPEIAFGRYSD.SLV..QKGYKVARVEQT 27 ELGL......VFMKG........---..--NWAHSGFPEIAFGRYSD.SLV..QKGYKVARVEQT 28 ELGL......VFMKG........---..--NWAHSGFPEIAFGRYSD.SLV..QKGYKVARVEQT 29 LLDI......SLTKR........GASa.GEPIPMAGIPHHAVENYLA.KLV..NQGESVAICEQI 30 ELGL......IFMKG........---..--NWAHSGFPEIAFGRFSD.SLV..QKGYKVARVEQT 31 EVFK......TQGVIkymg....PAG..AKTLQTVVLSKMNFESFVK.DLLl.VRHYRVEVYKNK 32 ELGL......VFMKG........---..--NWAHSGFPEIAFGRYSD.SLV..QKGYKVARVEQT 33 ELGL......IFMKG........---..--NWAHSGFPEIAFGRFSD.SLV..QKGYKVARVEQT 34 ILEI......SLTSR........NKNa.DNPIPMAGVPYHSAQQYID.VLI..EQGYKVAIAEQM 35 NLDI......TLTQR........---..-QNVPMSGIPATCLDGYVD.RLV..SRGFKVAIAEQA 36 LLDI......TLTTRg.......QVD..GEPVKMAGVPFHAAEQYLA.RLV..KLGKSVAICEQV 37 ELEI......TLTSR........DGGa.AEKIPMCGVPYHSASAYIE.QLI..KKGYKVAICEQT 38 LLDI......TLTTRg.......QVD..GEPVKMAGVPFHAAEQYLA.RLV..KLGKSVAICEQV 39 LLDI......TLTQR........GSSg.GAPIPMAGVPVHAYEGYLA.RLI..ALGESVAICEQI 40 HLEL......TLTQR........---..-QGIPMSGIPVSTVDTYVD.RLI..GKGFKVAVAEQF 41 ELNI......YCHLD........---..-HNFMTASIPTHRLFVHVR.RLV..AKGYKVGVVKQT 42 ELNI......YCHLD........---..-HNFMTASIPTHRLFVHVR.RLV..AKGYKVGVVKQT 43 ELNI......YCHLD........---..-HNFMTASIPTHRLFVHVR.RLV..AKGYKVGVVKQT 44 ELGL......VLTSRpa......GKG..RERIPMCGVPYHSANNYIA.KLV..NKGYKVAICEQV 45 ELEI......TLTSR........DGGa.AEKIPMCGVPYHSASAYIE.QLI..KKGYKVAICEQT 46 HLEL......TLTQR........---..-QGIPMSGIPVSTVDTYVD.RLI..GKGFKVAVAEQF 47 NLDI......TLTQR........---..-QNIPMSGIPAAYLDGYVD.RLV..SRGFKIAIAEQA 48 EVFK......TNGVIkyl.....GSG..NKKLESVVLSKMNFESVVK.DLLl.VRQYRVEVYKNK 49 ELGL......VLTSRpa......GKG..KERIPMCGVPYHSANSYIA.KLV..NKGYKVAICEQV 50 LFDL......KIAGG........--G..RANMQLAGIPEMSFEYWAA.QFI..QMGYKVAKVDQR 51 LFDL......KIAGG........--G..RANMQLAGIPEMSFEYWAA.QFI..QMGYKVAKVDQR 52 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 53 ELNI......YCHLD........---..-HNFMTASIPTHRLFVHVR.RLV..AKGYKVGVVKQT 54 ILGI......ALTKR........GKNc.EEEIPMCGVPYHALEHYLT.KLI..EENYKVAICDQL 55 VFSL......KLTDR........---..-VNMKMVGIPEASFDYWAS.QFI..AKGYRIARVDQL 56 LLGL......TLTKR........---..-NGTPMCGVPVHTARTHIA.RLL..KHGKKVALCEQV 57 ELDI......QYMKG........---..--EQPHCGFPEKNFSVNIE.KLV..RKGYRVLVVEQT 58 ALGI......TLTKR........GQHm.GQEIPMCGVPVHAADDYLQ.KLI..ASGYRVAVCEQV 59 ELDI......QYMKG........---..--EQPHCGFPEKNFSVNIE.KLV..RKGYRVLVVEQT 60 ELNI......YCHLD........---..-HNFMTASIPTHRLFVHVR.RLV..AKGYKVGVVKQT 61 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 62 TYYH......TTTALrql.....GSG..SNALSSVSISRNMFETIAR.DLLleRNDHTVELYEGS 63 ELNI......YCHLD........---..-HNFMTASIPTHRLFVHVR.RLV..AKGYKVGVVKQT 64 LLNL......TLTKR........---..-ENVPMCGVPYHTSKEYIR.KLI..LFDKKVAICEQA 65 ALNI......AFMRG........---..--SYAHAGFPEHAASKFAD.QLM..NHGYKVARIEQT 66 VLEI......TLTKR........DAKk.ENPIPMCGVPYHSADSYID.TLV..NNGYKVAICEQM 67 IVYK......STAFIgallp...DDK..KETLQFVSMSKGNFELAVR.ELLl.VRNYRVEVY--- 68 TVYK......TTSVIrqlg....RSD..HTGLPSVTMTVTVFRQFLR.EALf.KLGKRIEIW--- 69 IVYK......STAFIgallp...DDK..KETLQFVSMSKGNFELAVR.ELLl.VRNYRVEVY--- 70 VLGI......SCYFE........---..-HNFLNASVPSYRIDYHLE.RLI..NFGLKVAVVRQT 71 VLGI......SCYFE........---..-HNFLNASVPSYRIDYHLE.RLI..NFGLKVAVVRQT 72 ELGF......TYMRG........---..--EFAHSGFPEISFDKMST.ILV..DRGFKVARVEQT 73 ILHI......KLVPGklt.....10npqDCNHRQFAYCSFPDVRLNV.HLE..RLVHHNLKVAVV 74 VLGI......YAHMD........---..-HNFMTASVPTFRLNFHVR.RLV..NAGYKIGVVKQT 75 TYYH......TTTALrql.....GSG..SNALSSVSISRNMFETIAR.DLLleRNDHTVELYEGS 76 ILHI......KLVPGklt.....10npqDCNHRQFAYCSFPDVRLNV.HLE..RLVHHNLKVAVV 77 SVYH......TQSVLknc.....10vtaKNFHEPTKYVTVSLQVLAT.LLKl.CLLDLGYKVEIY 78 SVYH......TQSVLknc.....10vtaKNFHEPTKYVTVSLQVLAT.LLKl.CLLDLGYKVEIY 79 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 80 LLNL......RVSKK........KTS..KSDVSMAGFPFFKLDRYLK.ILVe.DLKKCVALSEEV 81 ELDW......KMTMS........GV-..-GKCRQVGISESGIDEAVQ.KLL..ARGYKVGRIEQL 82 IVYK......STAFIgallp...DDK..KETLQFVSMSKGNFELAVR.ELLl.VRNYRVEVY--- 83 TYYH......TMSALrql.....GSS..SDGILSASVSKAMFETIAR.NILleRTDCTLELYEGS 84 ELDW......KMTMS........GV-..-GKCRQVGISESGIDEAVQ.KLL..ARGYKVGRIEQL 85 NAYH......TTSVL........KHHn.VSNTSYCNLSPSLFIKFAE.DVLs.NLAKRVEIW--- 86 NAYH......TTSVL........KHHn.VSNTSYCNLSPSLFIKFAE.DVLs.NLAKRVEIW--- 87 VLGI......YAHMD........---..-HNFMTA------------.---..--GYKIGVVKQT 88 ELDW......KMTVS........GV-..-GKCRQVGISESGIDDAVD.KLI..ARGYKVGRIEQM 89 ELDW......KMTVS........GV-..-GKCRQVGISESGIDDAVD.KLI..ARGYKVGRIEQM 90 VLGI......YAHMD........---..-HNFMT-------------.---..-ARYKIGVVKQT 91 ELNI......SLTNR........AYS..HGKVPFAGFPVHQLSRHLK.MLVn.NCGYSVTIAEQF 92 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 93 ELNI......SLTNR........AYS..HGKVPFAGFPVHQLSRHLK.MLVn.NCGYSVTIAEQF 94 NIFKsdvcvkTFTLS........TDN..SQQMKYISVNRGQYEKVVReTIV..LLRCSVELY--- 95 YIRS......TAVLK........NWG..GVDVVVVNDS-IAKEVIRD.CLL..RRGASVEYYER- 96 EVFK......TQGVIkymg....PAG..AKNLQSVVLSKMNFESFVK.DLLl.VRQYRVEVYKNR 97 ----......-----........-GP..RSGIPSASFPSPQP-----.---..------------ 98 ----......-----........-GP..RSGIPSASFPSPQP-----.---..------------ 99 ----......-----........---..-------------------.---..------------ 100 ----......-----........---..-------------------.---..------------ 101 ----......-----........---..-------------------.---..------------ 102 ----......-----........---..-------------------.---..------------ 103 ----......-----........---..-------------------.---..------------ 104 ----......-----........---..-------------------.---..------------ 105 ----......-----........---..-------------------.---..------------ 106 ----......-----........---..-------------------.---..------------ 107 ----......-----........---..-------------------.---..------------ 108 ----......-----........---..-------------------.---..------------ 109 ----......-----........---..-------------------.---..------------ 110 LLDM......KIISL........--G..KRSLLQMGFPVYSLTTHLS.TLL..DKGWTVIVIDEL 111 ----......-----........---..-------------------.---..------------ 112 ----......-----........---..-------------------.---..------------ 113 ELNI......YCHLD........---..-HNFMTASIPTHRLFVHVR.RLV..AKGYKVGVVKQT 114 ----......-----........---..-------------------.---..------------ 115 VLGI......YAHMD........---..-HSFMTASVPTFRLNVHVR.GLV..NAGYKVGVVKQT 116 ----......-----........---..-------------------.---..------------ 117 ----......-----........---..-------------------.---..------------ 118 ELEL......VLTSK........EAGkeVGRVPMAGIPYHALDRYAS.QLV..EKGYAIAICDQV 119 LLNL......RVSKK........KTS..KSDVSMAGFPFFKLDRYLK.ILVe.DLKKCVALSEEV 00 110 120 130 | | | | 1 EPA...EEAE........GLVRREVTQLLTPGTLLQ....ESLL...P........REANYLAAI 2 EPA...EEAE........GLVRREVTQLLTPGTLLQ....ESLL...P........REANYLAAI 3 GDP...ATSK........GPVERKVVRIVTPGTISD....EALLq..E........RQDNLLAAI 4 GDP...ATSK........GPVERKVVRIVTPGTISD....EALLq..E........RQDNLLAAI 5 GDP...ATSK........GPVERKVVRIVTPGTISD....EALLq..E........RQDNLLAAI 6 EPA...EEAE........GLVRREVTQLLTPGTLTQ....EALL...P........REANYLAAI 7 EPA...EEAE........GLVRREVTQLLTPGTLTQ....EALL...P........REANYLAAI 8 GDP...TTSK........GPVERQIVRIVTPGTVSD....EALLp..E........RQDNLIAAV 9 GDP...ATTK........GPVERQVVRIITPGTVSD....EALLd..E........RRDNLLAAV 10 GDP...ATSK........GPVERQVVRIITPGTVSD....EALLd..E........RRDNLLAAI 11 GDP...ATSK........GPVERQVVRIITPGTVSD....EALLd..E........RRDNLLAAI 12 GDP...ATSK........GPVERKVVRIVTPGTVTD....EALLs..E........RVDNLIAAI 13 EPA...EEAE........GLVRREVTQLLTPGTLTQ....EALL...P........REANYLAAI 14 GDP...ATSK........GPVERKVVRIVTPGTISD....EALLq..E........RQDNLLAAI 15 EPA...EEAE........GLVRREVTQLLTPGTLTQ....EALL...P........REANYLAAI 16 EEP...SKSK........KLIRREVTRVVTPGSIVE....DEFL...S........ETNNYMAVV 17 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 18 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 19 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 20 EEP...SKSK........KLIRREVTRVVTPGSIVE....DEFL...S........ETNNYMAVV 21 EDA...AEAQaek.....RMVERQVTKLLTPGTLTD....DSMLp..A........KRNNFLAAI 22 EDA...AEAQaek.....RMVERQVTKLLTPGTLTD....DSMLp..A........KRNNFLAAI 23 AG-...NKAS........KENEWYLAFKASPGNLSQf...EDIL...F........GNNDMSASV 24 AG-...NKAS........KENEWYLAFKASPGNLSQf...EDIL...F........GNNDMSASV 25 ETP...EMMEarc.....13kydRVVRREICRIITK....GTQT...Ysvle....GDPSENYSK 26 ETP...EMMEarc.....13kydRVVRREICRIITK....GTQT...Ysvle....GDPSENYSK 27 ETP...EMMEarc.....13kydRVVRREICRIITK....GTQT...Ysvle....GDPSENYSK 28 ETP...EMMEarc.....13kydRVVRREICRIITK....GTQT...Ysvle....GDPSENYSK 29 GDP...ATSK........GPVERKVVRIVTPGTISD....EALLq..E........RQDNLLAAI 30 ETP...EMMEarc.....13kfdRVVRREICRIITK....GTQT...Ysvld....GDPSENYSR 31 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMATSI 32 ETP...EMMEarc.....13kydRVVRREICRIITK....GTQT...Ysvle....GDPSENYSK 33 ETP...EMMEarc.....13kfdRVVRREICRIITK....GTQT...Ysvld....GDPSENYSR 34 EDP...KQAV........GVVKREVVQVITPGTVVD....SSKP...D........SQNNFLVSI 35 DNT...EGSK........GLVPRTINRLITPGALLS....SSLLp..E........KANNYVLAI 36 GEV...GAGK........GPVERKVVRIVTPGTLTD....SALLe..D........KETNRIVAV 37 EDP...KAAK........GVVKREVVQLITPGTVMD....GKGIh..E........SENNFIASV 38 GEV...GAGK........GPVERKVVRIVTPGTLTD....SALLe..D........KETNRIVAV 39 GDP...GLAK........GLVERKVVRIVTPGTITD....EVLLe..E........RRDTLLMAL 40 GEP...AKEKeskki...GPMARDIQRFVTPGTLLS....STLLq..E........KFNNYIVAI 41 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG....EDVN...Plir.....16mtdTSTN 42 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG....EDVN...Plir.....16mtdTSTN 43 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG....EDVN...Plir.....16mtdTSTN 44 EDP...SKAK........GIVKRDVIRVITPGTFFE....----...-........RETGGLCSL 45 EDP...KAAK........GVVKREVVQLITPGTVMD....GKGIh..E........SENNFIASV 46 GEP...AKEKeskki...GPMARDIQRFVTPGTLLS....STLLq..E........KFNNYIVAI 47 DNS...EGGK........GLVPRTINRLITPGALLS....SSLLp..E........KANNYIIAI 48 SG-...GKYS........KENDWQLAFKASPGNLTQf...EEIL...F........GNNDMSTAV 49 EDP...SKAK........GIVKREVVRVITPGTFFE....----...-........RDTGGLASL 50 ESM...LAKEmregsk..GIVKRELQCILTSGTLTD....GDMLh..S........DLATFCLAI 51 ESM...LAKEmregsk..GIVKRELQCILTSGTLTD....GDMLh..S........DLATFCLAI 52 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 53 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG....EDVN...Plir.....16mtdTSTN 54 ETP...EEAKkrdgyk..AVVTRDVTRIITPGTIIE....ENLIs..V........TEPNYLTSL 55 ETA...LGKEikd.....11keeKVVQRGLTQVLTS....GTLV...D........EAMLtSDLS 56 SHP...-VPG........ELTQRKVIEIISPGTAVE....DDFLs..Q........GFSQYLATV 57 ETP...DQLEqrr.....10skdKVVKREVCAVVTK....GTLT...D........GEMLltNPD 58 EDP...AEAKkrgsk...SVVRRDVVRLVTPGTITE....DKLLs..P........SESNYLMAL 59 ETP...DQLEqrr.....10skdKVVKREVCAVVTK....GTLT...D........GEMLltNPD 60 ETA...ALKAigdnrs..SLFSRKLTALYTKSTLIG....EDVN...Plik.....16mtdTSTS 61 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 62 GS-...----........---NWRLVKTGSPGNIGSf...EDVL...Fannem...QDTPVVVSI 63 ETA...ALKAigdnrs..SLFSRKLTALYTKSTLIG....EDVN...Plik.....16mtdTSTS 64 SN-...STSG........GPLEREVVEVITPGVIID....EDFLn..D........DINNYLVAI 65 ETP...QMLEern.....10tkeKVVRREVCRVTSN....GTRT...Y........GVLDGvdl1 66 EDP...KQTK........GMVRREVVRIVTPGTVMEq...GGVD...D........KQNNYILSF 67 ---...--VK........NSSDWEIEYRGSPGNLLQf...EDIL...F........SNKEVLVGN 68 ---...ASPS........GRMNWKVVKQASPGNLQDv...EDELggqF........EGAPVILAV 69 ---...--VK........NSSDWEIEYRGSPGNLLQf...EDIL...F........SNKEVLVGN 70 ETA...ALKStsssrn..TLFDRRVARVLTKGTTLD....DSFFr..-feq.....9hgtlQASQ 71 ETA...ALKStsssrn..TLFDRRVARVLTKGTTLD....DSFFr..-feq.....9hgtlQASQ 72 ETP...DMMTerc.....12kfdKVVAREICQITNR....GTQV...F........GSQCkig-p 73 EQA...ETSA........IKKhdpgasksSVFERKI....SNVF...T........KATFGVNST 74 ETA...AIKShganrt..GPFFRGLSALYTKATLEAa...EDIS...Ggcg.....9egfgSQSN 75 GS-...----........---NWRLVKTGSPGNIGSf...EDVL...Fannem...QDTPVVVSI 76 EQA...ETSA........IKKhdpgasksSVFERKI....SNVF...T........KATFGVNST 77 DK-...----........------GWKLIKSASPGN....IEQv...N........ELMnmnIDS 78 DK-...----........------GWKLIKSASPGN....IEQv...N........ELMnmnIDS 79 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 80 IRPvddLSSK........NMYIRSVTRVITPGTLID....ENFMn..P........YESNYILTV 81 ETS...DQAKargan...TIIPRKLVQVLTPSTASE....GNIG...P........-DAVHLLAI 82 ---...--VK........NSSDWEIEYRGSPGNLLQf...EDIL...F........SNKEVLVGN 83 GS-...----........---NWRLTKSGTPGNIGSf...EDIL...Fanndm...EDSPVIVAL 84 ETS...DQAKargan...TIIPRKLVQVLTPSTASE....GNIG...P........-DAVHLLAI 85 ---...GANS........AKTGFELLKQASPGNMQMl...EDLL...Vsen.....13sdsSVSS 86 ---...GANS........AKTGFELLKQASPGNMQMl...EDLL...Vsen.....13sdsSVSS 87 ETA...AIKShganrt..GPFFRGLSALYTKATLEAa...EDIS...Ggcg.....9egfgSQSN 88 ESA...NQAKargvh...SVIERKLVHVSTPSTAVDni..----...G........TDAVHLLAL 89 ESA...NQAKargvh...SVIERKLVHVSTPSTAVDni..----...G........TDAVHLLAL 90 ETA...AIKShganrt..GPFFRGLSALYTKATLEAa...EDIS...Ggcg.....9egfgSQSN 91 KKK...DVADnea.....NKFYRRVTRIVTPGTFID....EAFEn..L........RENTYLLNI 92 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 93 KKK...DVADnea.....NKFYRRVTRIVTPGTFID....EAFEn..L........RENTYLLNI 94 ---...--SS........EQGEWKMTKRGSPGNTVDfe..QEIG...V........SDQAPILAI 95 ---...--PP........GGGTYACVQRGSPGNITDf...EATL...Fsfe.....22nnkGGNA 96 AG-...NKAS........KENDWYLAYKASPGNLSQf...EDIL...F........GNNDMSASI 97 ---...----........--------PMAGPGGIEE....EDEE...E........PAEIHLCVL 98 ---...----........--------PMAGPGGIEE....EDEE...E........PAEIHLCVL 99 ---...----........------VTRVITPGTLID....ENFMn..P........YESNYILTV 100 ---...----........------------------....--EQ...F........RDETVLSLS 101 ---...----........------------------....--EQ...F........RDETVLSLS 102 ---...----........------------------....-AIS...A........HSPSVIVAV 103 ---...----........------------------....----...-eee.....LAEIHLCVL 104 ---...----........------------------....-AIS...A........HSPSVIVAV 105 ---...----........------------------....----...-eee.....LAEIHLCVL 106 ---...----........------------------....----...-eee.....LAEIHLCVL 107 ---...----........------------------....--LLg..P........SIDCVLCCI 108 ---...----........------------------....--LLg..P........SIDCVLCCI 109 ---...----........------------------....--EQ...F........RDETVLSLS 110 VTN...--KS........GPKQRAVSQVYSPSCNLE....DCPEl..-........---PYVLSI 111 ---...----........------------------....----...-........NSDVVIVV- 112 ---...----........------------------....----...-........--------- 113 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG....EDVN...Plir.....16mtdTSTN 114 ---...----........------------------....----...-........--------- 115 ETA...AIKShganra..GPFFRGLSGLYTKATLEAa...EDIS...Ggcv.....9egfgGQSN 116 ---...----........------------------....----...-fdf.....DEEIVMCID 117 ---...----........------------------....----...-stifsfdfDEEIVMCID 118 ETA...AQAQg.......PLVRREITRIITPGTILE....EGMLq..A........RRNNFLAAV 119 IRPvddLSSK........NMYIRSVTRVITPGTLID....ENFMn..P........YESNYILTV 140 150 160 170 1 | | | | 1 A........TGDG........WGLAFLDVSTGEFKGTVLKS........KSALYDELFRHRPAEV 2 A........TGDG........WGLAFLDVSTGEFKGTVLKS........KSALYDELFRHRPAEV 3 Wq.......DSKG........FGYATLDISSGRFRLSEPAD........RETMAAELQRTNPAEL 4 Wq.......DSKG........FGYATLDISSGRFRLSEPAD........RETMAAELQRTNPAEL 5 Wq.......DSKG........FAYATLDISSGRFRLSEPAD........RETMAAELQRTNPAEL 6 A........TGDG........WGLAFLDVSTGEFKGTLLKS........KSALYDELFRHRPAEV 7 A........TGDG........WGLAFLDVSTGEFKGTLLKS........KSALYDELFRHRPAEV 8 Yq.......EKEK........FGLATLDMTSGRFQLCEPAD........KETLRAELQRIAPVEL 9 Vg.......DERL........FGLAILDITSGRFNVQEIQG........WENLLAELERLNPAEL 10 Lg.......DERL........FGLAVLDITSGRFSVQEIKG........WETLLAELERLNPAEL 11 Lg.......DERL........FGLAVLDITSGRFSVQEIKG........WETLLAELERLNPAEL 12 Yh.......HNGR........FGYATMDITSGRFQLSEPQT........EEEMAAELQRTSPREL 13 A........TGDG........WGLAFLDVSTGEFKGTLLKS........KSALYDELFRHRPAEV 14 Wq.......DGKG........YGYATLDISSGRFRLSEPAD........RETMAAELQRTNPAEL 15 A........TGDG........WGLAFLDVSTGEFKATLLKS........KSALYDELFRHRPAEV 16 Se.......EKGR........YCTVFCDVSTGEVLVHESSD........EQETLDLLKNYSISQI 17 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 18 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 19 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 20 Se.......EKGR........YCTVFCDVSTGEVLVHESSD........EQETLDLLKNYSISQI 21 Am.......VEDK........WGLAHADISTGEFFTCQSSN........LDDLAVELLRLQPSEV 22 Am.......VEDK........WGLAHADISTGEFFTCQSSN........LDDLAVELLRLQPSEV 23 Gvmg.....10vvd.......GQRHVGVGYVDSTQRKLGLC........EFPEndqFSNLEALLI 24 Gvmg.....10vvd.......GQRHVGVGYVDSTQRKLGLC........EFPEndqFSNLEALLI 25 Y........LLSL........KekeedssgHTRAYGVCFVD........TSLGKFFIGQFSDdrh 26 Y........LLSL........KekeedssgHTRAYGVCFVD........TSLGKFFIGQFSDdrh 27 Y........LLSL........KekeedssgHTRAYGVCFVD........TSLGKFFIGQFSDdrh 28 Y........LLSL........KekeedssgHTRAYGVCFVD........TSLGKFFIGQFSDdrh 29 Wq.......DGKG........YGYATLDISSGRFRLSEPAD........RETMAAELQRTNPAEL 30 Y........LLSL........KekeeetsgHTRVYGVCFVD........TSLGKFFIGQFSDdrh 31 Gimg.....10tvd.......GQRQVGVGDVDSTQRKLGLC........EFPDndqFSNLEALLI 32 Y........LLSL........KekeedssgHTRAYGVCFVD........TSLGKFFIGQFSDdrh 33 Y........LLSL........KekeeetsgHTRVYGVCFVD........TSLGKFFIGQFSDdrh 34 Dr.......EGNQ........FGLAYMDLVTGDFYVTGLLD........FTLVCGEIRNLKAREV 35 Nq.......VGSL........YGLSCLDLSIGTFLVAEYDN........TKDLIEAICRLAPTEL 36 Sp.......DKKY........IGLAWASLQSGEFKTKLTT-........VDKLDDELARLQAAEI 37 Sa.......CSNG........YGLALSDLTTGENLAVLIER........LEDVISEIYSVGAREI 38 Sp.......DKKY........IGLAWASLQSGEFKTKLTT-........VDKLDDELARLQAAEI 39 Sr.......SKNC........YGLAWADLAGGRFLVNEVNS........EEALEAELARLEPAEL 40 Nr.......IGSL........FGFACLDLSTGSFFIEECEN........TKELVDEICRLAPSEV 41 Y........LLCI........Yeek11kkkGNLSVGVVGVQ........PATGEVVFDCFQDsas 42 Y........LLCI........Yeek11kkkGNLSVGVVGVQ........PATGEVVFDCFQDsas 43 Y........LLCI........Yeek11kkkGNLSVGVVGVQ........PATGEVVFDCFQDsas 44 Yr.......KGKS........YLVSYLNLSVGEFIGAKVK-........EEELIDFLSKFNIREV 45 Sa.......CSNG........YGLALSDLTTGENLAVLIER........LEDVISEIYSVGAREI 46 Nr.......IGSL........FGFACLDLSTGSFFIEECEN........TKELVDEICRLAPSEV 47 Sq.......VGSL........YGLSCLDLSTGTFLVAEYDN........TKDLIEAVYRLAPTEL 48 Gvvg.....10sse.......GQRLVGVGYVDSTLRKLGVC........EFPDndqFSNLEALLV 49 Yk.......KGNH........YYVGYLNLAVGEFLGAKVK-........IEELLDLLSKLNIKEI 50 Reep.....21qkl.......NTKIFGAAFIDTATGELQML........EFEDdseCTKLDTLMS 51 Reep.....21qkl.......NTKIFGAAFIDTATGELQML........EFEDdseCTKLDTLMS 52 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 53 Y........LLCI........Yeek11kkkGNLSVGVVGVQ........PATGEVVFDCFQDsas 54 Vipk.....NKKT........ASICCVDLSTSKIFVINVP-........ETEILNELARLKSREI 55 T........YCMA........IKeslqsdnEEPSFGICFID........TSTGGFHMCEFTDdih 56 Ca.......SDAT........VAFSYLEVSTGAFFITSFPRaea.....ADALQKEFGRVQPSEV 57 A........SYLM........ALTeggesl----tnptaehn.......FGVCLVDVATQKIILG 58 Arirsg...SEPA........YALAWIDISTGIFRLAETA-........ESRLLADILRIEPREL 59 A........SYLM........ALTeggesl----tnptaehn.......FGVCLVDVATQKIILG 60 Y........LLCI........Senk11kkk----gnifIGI........VGVQPATGEVVFDSFQ 61 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 62 Fpsfhd...GRCV........IGMAYVDLTRRVLGLAEFLDdsr.....FTNLESSLIALGAKEC 63 Y........LLCI........Senk11kkk----gnifIGI........VGVQPATGEVVFDSFQ 64 Sd.......YKDY........YSFSYIDLSTSSLGIMFYENgf......FEKLKRDLEKYSPKEI 65 1tld.....PTAK........HLLAIKefhnpetGKSSYGV........CMIDTTTAHIRIGQFE 66 Vm.......NQPE........IALSYCDVSTGELKVTHFND........EATLLNEITTINPNEV 67 Siis.....11dgg.......GQRRVGVASVEQNDCKFQLL........EFLDddfFTELEATVV 68 Kisakas..EART........VGVCFADASVRELGVSEFLDndl.....YSNFEALLIQLGVKEC 69 Siis.....11dgg.......GQRRVGVASVEQNDCKFQLL........EFLDddfFTELEATVV 70 F........ILCV........Adnv9skakSGR-vqVGLIA........IQLSSGTTVYDHFQDd 71 F........ILCV........Adnv9skakSGR-vqVGLIA........IQLSSGTTVYDHFQDd 72 n........HQPN........YMLAIVekdegTCSRYGVCF........IDTSIGDFHLGEFEDd 73 F........Vlrgkril....GDTNSIWALSrdvhQGK-vak.......YSLISVNLNNGEVVYD 74 F........LVCV........VDERVkse16dvrVGVVGVE........ISTGEVVYEEFNDnfm 75 Fpsfhd...GRCV........IGMAYVDLTRRVLGLAEFLDdsr.....FTNLESSLIALGAKEC 76 F........Vlrgkril....GDTNSIWALSrdvhQGK-vak.......YSLISVNLNNGEVVYD 77 S........IIIA........SLKvqwnsqdGNCIIGVAFI........DTTAYKVGMLDIVDne 78 S........IIIA........SLKvqwnsqdGNCIIGVAFI........DTTAYKVGMLDIVDne 79 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 80 Vfdp.....22dcf.......ADCKIGLSWLDLSTGEFFTQ........DSN-LQRLAGDLTRIS 81 KeikmelqkCSTV........YGFAFVDCAALRFWVGSISDdas.....CAALGALLMQVSPKEV 82 Siis.....11dgg.......GQRRVGVASVEQNDCKFQLL........EFLDddfFTELEATVV 83 Fpacre...SQLY........VGLSFLDMTNRKLGLAEFPEdsr.....FTNVESALVALGCKEC 84 KeikmelqkCSTV........YGFAFVDCAALRFWVGSISDdas.....CAALGALLMQVSPKEV 85 V........LLAV........TtrvkqDQRIIGVAFIDPIL........KKLGVSEFVDsdaYTN 86 V........LLAV........TtrvkqDQRIIGVAFIDPIL........KKLGVSEFVDsdaYTN 87 F........LVCV........VDERVkse16dvrVGVVGVE........ISTGEVVYEEFNDnfm 88 Kevtlass.GFQV........FGFAFLDYAALKIWVGSVQDdds.....SAALGALLMQVSPREL 89 Kevtlass.GFQV........FGFAFLDYAALKIWVGSVQDdds.....SAALGALLMQVSPREL 90 F........LVCV........VDERVkse16dvrVGVVGVE........ISTGEVVYEEFNDnfm 91 Efpe.....11vad.......TSLKVGICWCDVSTGEIFVQ........QVY-LRDLVSAITRIQ 92 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 93 Efpe.....11vad.......TSLKVGICWCDVSTGEIFVQ........QVY-LRDLVSAITRIQ 94 Yihpgd...DDNR........VTLCAWDAGNVRIVISEYIDtps.....FSQTEQCIFGLCPTEY 95 G........KCMI........Sg-GQGirVGFAALNTTLRT........LTYAEYLDtlqLTSLD 96 Gvvg.....10avd.......GQRQVGVGYVDSIQRKLGLC........EFPDndqFSNLEALLI 97 W........SSGY........LGIAYYDTSDSTIHFMPDAPdhes....LKLLQRVLDEINPQSV 98 W........SSGY........LGIAYYDTSDSTIHFMPDAPdhes....LKLLQRVLDEINPQSV 99 Vfdp.....22dcf.......ADCKIGLSWLDLSTGEFFTQ........DSN-LQRLAGDLTRIS 100 F........AQGM........LGAAYYEQSSQLLKIMNDISedle....FRFLKRLIDDVKPTLI 101 F........AQGM........LGAAYYEQSSQLLKIMNDISedle....FRFLKRLIDDVKPTLI 102 V........EGRGlarge...IGMASIDLKNPQIILSQFADntt.....YAKVITKLKILSPLEI 103 W........NSGY........LGIAYYDTSDSTIHFMPDAPdhes....LKLLQRVLDEINPQSV 104 V........EGRGlarge...IGMASIDLKNPQIILSQFADntt.....YAKVITKLKILSPLEI 105 W........NSGY........LGIAYYDTSDSTIHFMPDAPdhes....LKLLQRVLDEINPQSV 106 W........NSGY........LGIAYYDTSDSTIHFMPDAPdhes....LKLLQRVLDEINPQSV 107 Yevprd...ISTR........IGLCIINCNTGQMYLSDFMDsqi.....YIRVVHKLQIYQPTEI 108 Yevprd...ISTR........IGLCIINCNTGQMYLSDFMDsqi.....YIRVVHKLQIYQPTEI 109 F........AQGM........LGAAYYEQSSQLLKIMNDISedle....FRFLKRLIDDVKPTLI 110 Yfs......QDDL........LGITLFSAMNGHSIIFPVSWtd......RDKVTRLLISYHIREI 111 -megrgs..CEGH........IGIALHDTCFPEIHLCEFVDsre.....YTTLKTMINVHEAFDI 112 -........----........--------------------........---------------- 113 Y........LLCI........Yeek11kkkGNLSVGVVGVQ........PATGEVVFDCFQDsas 114 -........----........--------------------........---------------- 115 F........LVCV........VDERVdre17dvrVGVVGVE........ISTGEVVHGEFNDnfm 116 F........SGGK........LGCSILDYHTKTLKAFDQDYvvn.....23ndiSLLLGLLIMEA 117 -f.......SGGK........LGCSILDYHTKTLKAFDQDYvvnk....--------TTISSHDL 118 Vi.......AGEH........WGLAYADSSTGDYWTSQSTG........LEGL------------ 119 V........----........--------------------........---------------- 80 190 200 210 2 | | | | 1 LL.....APELLE........N....GAFLDEFRKRFPVMLSEA........PFEPEGEGPLALR 2 LL.....APELLE........N....GAFLDEFRKRFPVMLSEA........PFEPEGEGPLALR 3 LY.....AEDFAE........Ms...LIEGRRGLRRRPLWEFEIdta.....15trdLVGFGVEN 4 LY.....AEDFAE........Ms...LIEGRRGLRRRPLWEFEIdta.....15trdLVGFGVEN 5 LY.....AEDFAE........Ms...LIEGRRGLRRRPLWEFEIdta.....15trdLVGFGVEN 6 LL.....APELRE........N....EAFVAEFRKRFPVMLSEA........PFEPQGEGPLALR 7 LL.....APELRE........N....EAFVAEFRKRFPVMLSEA........PFEPQGEGPLALR 8 LY.....CEEFNE........Ma...AIEHCKGLRRRPIWEFELsta.....15tkdLRAFGVEK 9 LY.....PDDWPA........Gl...PLEKRRGAHRRAPWDFDFdsa.....15tqdLKGFGCDG 10 LI.....PDDWPQ........Gl...PAEKRRGVRRRAPWDFDRdsa.....15tqdLKGFGCQN 11 LI.....PDDWPQ........Gl...PAEKRRGVRRRAPWDFDRdsa.....15tqdLKGFGCQN 12 LF.....PEDFSP........Vh...LMASRQGNRRRPIWEFELdta.....15trdLVGFGVEQ 13 LL.....APELRE........N....EAFVAEFRKRFPVMLSEA........PFEPQGEGPLALR 14 LY.....AEDFAE........Ma...LIEGRRGLRRRPLWEFEIdta.....15trdLVGFGVEN 15 LL.....APELRE........N....EAFVAQFRKRFPVMLSEA........PFDPEGEAPLALS 16 IC.....PEHLKS........S....LKERFPGVYTETISEWYFsdl.....12ynlKDIHHFEL 17 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 18 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 19 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 20 IC.....PEHLKS........S....LKERFPGVYTETISEWYFsdl.....12ynlKDIHHFEL 21 LI.....PTSAPD........I....RNILRPGEPSEHIPKQLPtsf.....30vksLEGMGCEG 22 LI.....PTSAPD........I....RNILRPGEPSEHIPKQLPtsf.....30vksLEGMGCEG 23 QI.....GPKECV........L....PGGETTGdMGKLRQVIQR........GGILITERkra27 24 QI.....GPKECV........L....PGGETTGdMGKLRQVIQR........GGILITERkra27 25 CS.....RFRTLV........A....HYPPVQVLFEKGNLSKeT........KTILKSSLSCSLQ 26 CS.....RFRTLV........A....HYPPVQVLFEKGNLSKeT........KTILKSSLSCSLQ 27 CS.....RFRTLV........A....HYPPVQVLFEKGNLSKeT........KTILKSSLSCSLQ 28 CS.....RFRTLV........A....HYPPVQVLFEKGNLSKeT........KTILKSSLSCSLQ 29 LY.....AEDFAE........Ma...LIEGRRGLRRRPLWEFEIdta.....15trdLVGFGVEN 30 CS.....RFRTLV........A....HYPPVQILFEKGNLSTeT........KTVLKGSLSSCLQ 31 QI.....GPKECI........L....PGGETAGdMGKLRQVIQR........GGILITERkri27 32 CS.....RFRTLV........A....HYPPVQVLFEKGNLSKeT........KTILKSSLSCSLQ 33 CS.....RFRTLV........A....HYPPVQILFEKGNLSTeT........KTVLKGSLSSCLQ 34 VL.....GYDLSE........EeeqiLSRQMNLVLSYEKESFED........LHLLDLRLATVEQ 35 LS.....HAKFYQ........Kn...EAVIKQLQQHLRITLSEYvsw.....22vssLDGFGLQG 36 LL.....PDSKNA........P....QLQTASGVTRLNAWQFAAdag.....17dlrGFGLDGKE 37 VV.....SGSLDA........D....TVAQLRERCGATISIEDGetdeh...VTIIEHLNNEDIT 38 LL.....PDSKNA........P....QLQTASGVTRLNAWQFAAdag.....17dlrGFGLDGKE 39 LLp....DEDAWP........E....YLQQRNGVRRRPPWLFDAdsg.....15lhdLSGFGIEN 40 LS.....CNKFYN........Ke...TAIVMQLQQHLKLTLSTYadw.....22vasLDGFGLKG 41 RL.....ELETRI........S....SLQPVELLLPSDLSEPTE........MLIQRATNVSVRD 42 RL.....ELETRI........S....SLQPVELLLPSDLSEPTE........MLIQRATNVSVRD 43 RL.....ELETRI........S....SLQPVELLLPSDLSEPTE........MLIQRATNVRLKT 44 LVkk...GEKLPE........K....LEKVLKLHITELEEEFFEegk.....13gvpSIKAFGFQ 45 VV.....SGSLDA........D....TVAQLRERCGATISIEDGetdeh...VTIIEHLNNEDIT 46 LS.....CNKFYN........Ke...TAIVMQLQQHLKLTLSTYadw.....22vasLDGFGLKG 47 LS.....HAKFYQ........Kn...EPVVKQLQQHLRITLSEHvsw.....22vssLDGFGLQG 48 QI.....GPKECV........M....PGGETAGdMGKLRQIVKR........GGILITDRkra27 49 LVkk...GEKLPE........E....LEKVLKVYVSELEEEFFEegs.....13gvlSLQAFGFE 50 QV.....RPMEVV........M....ERNNLSTLANKIVKFNSA........PNAIFNEvka32p 51 QV.....RPMEVV........M....ERNNLSTLANKIVKFNSA........PNAIFNEvka32p 52 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 53 RL.....ELETRI........S....SLQPVELLLPSDLSEPTE........MLIQRATNVSVRD 54 LL.....SENLKS........Sn...ISDSILKQFNCRITYQVDsff.....19kirDIKGIGEI 55 RT.....KLDTLL........T....QVRPKELILEKSKISQks........IRAIKYCVSSSSI 56 LL.....SASVLR........S....LPELAAILSLYPRLVRTTgad.....23trnLDCLTLLP 57 QF.....KDdqdC........S....ALSCLLSEMRPVEIIKPA........KVLSYaTERTIVR 58 IL.....PDTVFH........D....PDLRPVFDVLGRVAVPQPavl.....20gvgTLDGFGSF 59 QF.....KDdqdC........S....ALSCLLSEMRPVEIIKPA........KVLSYaTERTIVR 60 Dsas...RSELET........R....MSSLQPVELLLPSALSEQ........TEALIHRATSVSV 61 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 62 IFpa...ESGKSN........E....CKSLYDSLERCAVMITERkkh.....23niePVRDLVSG 63 Dsas...RSELET........R....MSSLQPVELLLPSALSEQ........TEALIHRATSVSV 64 IV.....SENFYY........EysekLNLSRFLINRVPTWHLDKdia.....15ilgLSSLGFDE 65 Dddy...RSQLRT........L....LANVIVVQAIVERGSISS........TTKSIINGILFSV 66 VI.....NDNISD........N....LKRQINMVTETITVRETLsse.....IYSVNQTEHKLMY 67 LL.....GPKECL........L....P-SIEGEYSAVKTLLDRN........GVMITMPkks25q 68 IVtqdkgEKEKDP........E....LAKLRQIIDNCGVAIAERsag.....23eraASLLPQTD 69 LL.....GPKECL........L....P-SIEGEYSAVKTLLDRN........GVMITMPkks25q 70 fl.....RSELQT........R....LSHFQPCELIYSNKLSSE........SVALLNHYVSTEK 71 fl.....RSELQT........R....LSHFQPCELIYSNKLSSE........SVALLNHYVSTEK 72 kn.....CSRLLT........L....VSHHMPVLFLNEKSALSQ........RTQQIVRTVLGGI 73 EF.....EEpnla........D....EKLQIRIKYLQPIEVLVN........TDDLPLHVAKFFK 74 RS.....GLEAVI........L....SLSPAELLLGQPLSQQTE........KFLVAHAGPTSNV 75 IFpa...ESGKSN........E....CKSLYDSLERCAVMITERkkh.....23niePVRDLVSG 76 EF.....EEpnla........D....EKLQIRIKYLQPIEVLVN........TDDLPLHVAKFFK 77 vY.....SNLESF........L....IQLGVKECLVqdltsNSN........SNAEMQKVINVID 78 vY.....SNLESF........L....IQLGVKECLVqdltsNSN........SNAEMQKVINVID 79 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 80 PR.....EIVLDE........S....LKSFtTHPIYSFIQERKY........FLSYVenr18kei 81 LYd....SKGLSR........E....AQKALRKYTLTGSTAVQLapv.....33swnCAVDGLNE 82 LL.....GPKECL........L....P-SIEGEYSAVKTLLDRN........GVMITMPkks25q 83 LL.....PADCEK........Sid..LNPLQDVISNCNVLLTEKkka.....23svePVRDLLSQ 84 LYd....SKGLSR........E....AQKALRKYTLTGSTAVQLapv.....33swnCAVDGLNE 85 FE.....ALIVQV........G....AKECIISQSGHEstn13nta......EINRLRNIIEGCG 86 FE.....ALIVQV........G....AKECIISQSGHEstn13nta......EINRLRNIIEGCG 87 RS.....GLEAVI........L....SLSPAELLLGQPLSQQTE........KFLVAHAGPTSNV 88 IY.....ETSGIS........Ke...TQRTIRKYASAGSVKMQLtpl.....32swlSALDCTMN 89 IY.....ETSGIS........Ke...TQRTIRKYASAGSVKMQLtpl.....32swlSALDCTMN 90 RS.....GLEAVI........L....SLSPAELLLGQPLSQQTE........KFLVAHAGPTSNV 91 PK.....EILLDE........R....LLEfhi10wypELVELKK........FFIKYQKMPSQHr 92 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 93 PK.....EILLDE........R....LLEfhi10wypELVELKK........FFIKYQKMPSQHr 94 ILvn...EGSVAP........K....AKKIASMFTRMEVHNKQQlkp.....13iesVHLDYKDE 95 AL.....MAQCNL........K....ELIYlDKSRCRGGSNSDR........GGGAAGVCRRKRa 96 QI.....GPKECV........L....PGGETAGdMGKLRQIIQR........GGILITERkka27 97 VT.....SAKQDE........A....MTRFLGKLASEEHREPKGpei.....40ilfLSSIIPFD 98 VT.....SAKQDE........A....MTRFLGKLASEEHREPKGpei.....40ilfLSSIIPFD 99 PR.....EIVLDE........S....LKSFtTHPIYSFIQERKY........FLSYVenr18kei 100 IA.....NRSQDL........E....FIKFLTTRYDPQEKIYEDgtt.....84yiiIKMRFDIE 101 IA.....NRSQDL........E....FIKFLTTRYDPQEKIYEDgtt.....84yiiIKMRFDIE 102 IM.....SNTACA........V....GNSTKLFTLITENFKNVNftt.....27efsTVLMEVQS 103 VT.....SAKQDE........N....MTRFLGKLASQEHREPKRpei.....40ilfLSSIIPFD 104 IM.....SNTACA........V....GNSTKLFTLITENFKNVNftt.....27efsTVLMEVQS 105 VT.....SAKQDE........N....MTRFLGKLASQEHREPKRpei.....40ilfLSSIIPFD 106 VT.....SAKQDE........N....MTRFLGKLASQEHREPKRpei.....57gdlRFTPIPLL 107 LI.....PSSSLA........P....TVSKLATMIKFNVAETVKiee.....29kkdLKIEEIID 108 LI.....PSSSLA........P....TVSKLATMIKFNVAETVKiee.....29kkdLKIEEIID 109 IA.....NRSQDL........E....FIKFLTTRYDPQEKIYEDgtt.....84yiiIKMRFDIE 110 VIwa...DSGVCS........Nil..INKIYNLLIGWNLFPSEPnak.....56kifQSTWTENV 111 VI.....QNGNEE........R....GSTKLLGEALMTAFPEASlqs.....27evsTVSEGCLR 112 --.....------........-....------------------........------------- 113 RL.....ELETRI........S....SLQPVELLLPSDLSEPTE........MLIQRATNVRLKT 114 --.....------........-....------------------........------------- 115 RS.....GLEAVI........L....------------------........------------- 116 NP.....TVCLVP........A....RLEDWi------------........------fdy77nd 117 ID.....DADMSS........N....DISLLLGLLIMEANPTVClvp.....87ndsTASSNMVT 118 --.....------........-....------------------........------------- 119 --.....------........-....------------------........------------- 20 230 240 250 260 | | | | | 1 RARGALLAYAQRTQGG........AL...SLQPFRFYDP........G.AFMRLPEATLRALEVF 2 RARGALLAYAQRTQGG........AL...SLQPFRFYDP........G.AFMRLPEATLRALEVF 3 APRGLCAAGCLLQYAK........DT...QRTTLpHIRS........I.TMEREQDSIIMDAATR 4 APRGLCAAGCLLQYAK........DT...QRTTLpHIRS........I.TMEREQDSIIMDAATR 5 APRGLCAAGCLLQYAK........DT...QRTTLpHIRS........I.TMEREQDSIIMDAATR 6 RAQGALLAYARATQGG........AL...SVRPFRLYDP........G.AFVRLPEASLKALEVF 7 RAQGALLAYARATQGG........AL...SVRPFRLYDP........G.AFVRLPEASLKALEVF 8 SPLGLSAAGCLLQYAK........ET...QRTALpHIQS........I.SLIQNQDCIQLDAATR 9 LGLAIGAAGCLLAYAR........ET...QRTALpHLRG........L.RHERLDDTVILAGASR 10 LTLAIGAAGCLLAYAK........ET...QRTALpHLRS........L.RHDRLDDTVILDGASR 11 LTLAIGAAGCLLAYAK........ET...QRTALpHLRS........L.RHDRLDDTVILDGASR 12 AKLGLCAAGCLIQYVK........DT...QRTALpHIRS........L.TWDRQDQSVILDAATR 13 RAQGALLAYARATQGG........AL...SVRPFRLYDP........G.AFVRLPEASLKALEVF 14 ASRGLCAAGCLLQYVK........DT...QRTSLpHIRS........I.TMERQQDSIIMDAATR 15 RARGALLAYARATQGG........AL...SVRPFRLYDP........G.AIVRLPEASLKALEVF 16 SPLALKALAALIKYVK........YT...MIGEDlNLKP........P.LLISQRDYMILDSATV 17 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 18 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 19 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 20 SPLALKALAALIKYVK........YT...MIAEDlNLKP........P.LLISQRDYMILDSATV 21 LPLAIRAAGGLLEYIE........DT...QKAHVvPIQP........L.KTYGLTDFLVLDHQTR 22 LPLAIRAAGGLLEYIE........DT...QKAHVvPIQP........L.KTYGLTDFLVLDHQTR 23 qinSAALPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELATFDF 24 qinSAALPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELATFDF 25 EGLIpgs46sdsIGLT........PG...EKSELALSAL........G.GCVFYLKKCLIDQEll 26 EGLIpgs46sdsIGLT........PG...EKSELALSAL........G.GCVFYLKKCLIDQEll 27 EGLIpgs46sdsIGLT........PG...EKSELALSAL........G.GCVFYLKKCLIDQEll 28 EGLIpgs46sdsIGLT........PG...EKSELALSAL........G.GCVFYLKKCLIDQEll 29 ASRGLCAAGCLLQYVK........DT...QRTSLpHIRS........I.TMERQQDSIIMDAATR 30 EGLIpgs44sdsVGLT........PG...EESELALSAL........G.GIVFYLKKCLIDQEll 31 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELATFDF 32 EGLIpgs46sdsIGLT........PG...EKSELALSAL........G.GCVFYLKKCLIDQEll 33 EGLIpgs44sdsVGLT........PG...EESELALSAL........G.GIVFYLKKCLIDQEll 34 TASSKLLQYVHRTQMR........ELn..HLKPVIRYEI........K.DFLQMDYATKASLDLV 35 LVPAINAAGALLSYIQ........DK...LLLPIsHLSI........P.KIYGQQKHLLIDKASQ 36 HAVAIGAAGALLNYIR........LT...QNLMPqHLDG........L.SLETDSQYIGMDAATR 37 KTFLRLYTYLKRTQKR........SLd..HLQPVQVYEL........E.EAMKIDLYSKRNLELT 38 HAVAIGAAGALLNYIR........LT...QNLMPqHLDG........L.SLETDSQYIGMDAATR 39 NPQATAAAGALLGYIE........ET...QKQRLpHLTS........I.TMETVGEAITMNAATR 40 LVPAINAAGGLLSYIQ........DK...LLLPTkHIAI........P.QTRGKQQKLLIDTASQ 41 DRIrve34gsqSLSGV........IN...LEKPVICALA........A.VIRYLKEFNLEKMlsK 42 DRIrve34gsqSLSGV........IN...LEKPVICALA........A.VIRYLKEFNLEKMlsK 43 VRKlkt55gsqSLSGV........IN...LEKPVICALA........A.VIRYLKEFNLEKMlsK 44 DEDLSLSLGAVYRYAK........AT...QKSFTpLIPK........P.KPYVDEGYVKLDLKAV 45 KTFLRLYTYLKRTQKR........SLd..HLQPVQVYEL........E.EAMKIDLYSKRNLELT 46 LVPAINAAGGLLSYIQ........DK...LLLPTkHIAI........P.QTRGKQQKLLIDTASQ 47 LVPAINAAGALLSYIQ........DK...LLLPIsHLSI........P.KIYGQHKHLLIDKASQ 48 qvtSAALPEMEKQVAM........SA...LAAVMKYLEL........L.SDESNfGQFVMTNFDL 49 EDTYSLPLGAVYKYAK........TT...QKGYTpLIPR........P.KPYRDEGFVRLDIKAI 50 evLKSYYDTGKKVGFS........AF...GGLLYYLKWL........K.LDKNliSMKNIKEYDF 51 evLKSYYDTGKKVGFS........AF...GGLLYYLKWL........K.LDKNliSMKNIKEYDF 52 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 53 DRIrve34gsqSLSGV........IN...LEKPVICALA........A.VIRYLKEFNLEKMlsK 54 SNSQICAIGSILEYLS........LT...QKQNIpHLPI........P.KIINFHNYMTIDFSTR 55 WNFIKpyt30apkILK........SY...LSEKPLAISA........F.GALFWYLRQLKLDKDm 56 HSPDLAAAGALIAYLE........ET...TRHPLsHVSA........I.TRYHIHDFVEIDDATR 57 QTRNPLVNNLVpls49mls.....EL...ATEDKNGSLA........L.SALGGAIYYLRQAFLD 58 SRAELAAASAAVSYVE........KT...QLQERpALGI........P.ERESAASTLFIDPATR 59 QTRNPLVNNLVpls49mls.....EL...ATEDKNGSLA........L.SALGGAIYYLRQAFLD 60 QDDRIrve34gsqIIS........GI...VNLEKPVICS........L.AAIIKYLKEFNLEKMl 61 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 62 FDLATPALGALLSFSE........LL...SNEDNyGNFT........I.RRYDIGGFMRLDSAAM 63 QDDRIrve34gsqIIS........GI...VNLEKPVICS........L.AAIIKYLKEFNLEKMl 64 EKPYYISIFLIINHIK........NN...LKNLLsNIDK........I.DINNDSSYMFLDDVTQ 65 PVEHLlpk41dssILP........KP...STDWQLALSA........F.GAIFWYLRDSLIDVDm 66 QATQLLLDYIHHTQKR........DLs..HIEDVVQYAA........I.DYMKMDFYAKRNLELT 67 edATGLKELQLQLASN........AL...KTAIKYLDLV........N.DAGNlGHYEIKQLDLN 68 LKLAMGSASALIKYLG........IL...HDPSNfGQYQ........L.YQHDLAQFMKLDAAAL 69 edATGLKELQLQLASN........AL...KTAIKYLDLV........N.DAGNlGHYEIKQLDLN 70 TCGRVvrv36ielHME........KV...KSLHSLSIIC........L.DMAISYLMEFSLEDLf 71 TCGRVvrv36ielHME........KV...KSLHSLSIIC........L.DMAISYLMEFSLEDLf 72 LKEPVpgn44mdhLGL........TP...NDNYKLALKA........L.GQCIFFIHKCKLEPKv 73 DISCPLIHKQEydl12aik.....VM...NEKIQLSPSL........I.RLVSKLYSHMVEYNNE 74 RVEras46sclTVHTI........MN...MPHLTVQALA........L.TFCHLKQFGFERIlyQ 75 FDLATPALGALLSFSE........LL...SNEDNyGNFT........I.RRYDIGGFMRLDSAAM 76 DISCPLIHKQEydl12aik.....VM...NEKIQLSPSL........I.RLVSKLYSHMVEYNNE 77 RCGCVVTLLkns22ddl.......AL...SLPQKYSKLS........M.GACNALIGYLQLLSEQ 78 RCGCVVTLLkns22ddl.......AL...SLPQKYSKLS........M.GACNALIGYLQLLSEQ 79 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 80 DPSFIKYCTKLEVTAG........CT...LISYIADRLQ........N.SHpNIQPPIRVSLNEY 81 CDVALSALGELINHLS........RL...KLEDVlkHGD........I.FPYQVYRGCLRIDGQT 82 edATGLKELQLQLASN........AL...KTAIKYLDLV........N.DAGNlGHYEIKQLDLN 83 FDYALGPLGALLSYAE........LL...ADDTNyGNYT........I.EKYNLNCYMRLDSAAV 84 CDVALSALGELINHLS........RL...KLEDVlkHGD........I.FPYQVYRGCLRIDGQT 85 ALVTTIrss23pvtHA........LV...PELGLQLAMA........S.CNALLRYLGPALLNpd 86 ALVTTIrss23pvtHA........LV...PELGLQLAMA........S.CNALLRYLGPALLNpd 87 RVEras46sclTVQTI........MN...MPHLTVQALA........L.TFCHLKQFGFERIlyQ 88 QDVVICALGGLIGHLT........RL...MLHDAlkNGE........V.LPYHVYKTCLRMDGQT 89 QDVVICALGGLIGHLT........RL...MLHDAlkNGE........V.LPYHVYKTCLRMDGQT 90 RVEras46sclTVHTI........MN...MPHLTVQALA........L.TFCHLKQFGFERIlyQ 91 ti21erqLKIQFQTFT........QK...ELAALRNTLI........Y.VSNHLPDFSiNFQIPQ 92 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 93 ti21erqLKIQFQTFT........QK...ELAALRNTLI........Y.VSNHLPDFSiNFQIPQ 94 AEKQNENIKECLQILH........SN...AADEYsisEK........Y.SIFNYGTHGNMLIDSC 95 rr66rvpEDRLALSNC........PL...ASRAIEYLVS........N.IIDNFDATNhRAFYLK 96 qmnSAVLPEMENQVAV........SS...LSAVIKFLEL........L.SDDSNfGQFELTTFDF 97 CVLTVRALGGLLKFLS........RR...RIGveledyd........-.VgvPILGFKKFVLTHL 98 CVLTVRALGGLLKFLS........RR...RIGveledyd........-.VgvPILGFKKFVLTHL 99 DPSFIKYCTKLEVTAG........CT...LISYIADRLQ........N.SHpNIQPPIRVSLNEY 100 AVNMIRSFGALLLFLD........ET...RMGvtddpls........V.-tsPIKSIKTFTLGNL 101 AVNMIRSFGALLLFLD........ET...RMGvtddpls........V.-tsPIKSIKTFTLGNL 102 KYYCLAAVAALLKYVE........FI...QNSVYapKSL........K.ICFQGSEQTAMIDSSS 103 CLLTVRALGGLLKFLG........RR...RIGveledynv.......S.-vPILGFKKFMLTHLV 104 KYYCLAAVAALLKYVE........FI...QNSVYapKSL........K.ICFQGSEQTAMIDSSS 105 CLLTVRALGGLLKFLG........RR...RIGveledynv.......S.-vPILGFKKFMLTHLV 106 IPSQVRALGGLLKFLG........RR...RIGveledynv.......S.-vPILGFKKFMLTHLV 107 KTFALCAASAAISYME........EI...ISKssrnl--naf.....R.KLRIQFEGTENTMLID 108 KTFALCAASAAISYME........EI...ISKssrnl--naf.....R.KLRIQFEGTENTMLID 109 AVNMIRSFGALLLFLD........ET...RMGvtddpls........V.-tsPIKSIKTFTLGNL 110 NQANLISLLGVLQFIK........DR...NPNLIkNLQL........P.ECYNSvvsPLNLILCN 111 RTLALGALAVLLKYIH........ET...RCVFFrvKSL........R.IKEMGVNDTCMIDFVS 112 ----------------........--...----------........-.-----DTAALENLELL 113 ----------------........--...----------........-.---------------- 114 ----------------........--...----------........-.---------------- 115 ----------------........--...----------........-.---------------- 116 sTASSNMVTGRLVQNA........FE...----------........-.---dVIHGIRYIDIRD 117 GRLVQNAFE-------........--...-----dVIHG........I.RYIDIRDRMVLDENTI 118 ----------------........--...----------........-.---------------- 119 ----------------........--...----------........-.---------------- 270 280 290 300 310 | | | | | 1 EPLRGQ........DTLFSVLDETRT.APGRRLLQSWLRHPLLDRGPLEARLDRV........EG 2 EPLRGQ........DTLFSVLDETRT.APGRRLLQSWLRHPLLDRGPLEARLDRV........EG 3 RNLEIT........QNLAGGaeNTLA.SVLDCTVTPMGSRMLKRWLHMPVRDTRV........LL 4 RNLEIT........QNLAGGaeNTLA.SVLDCTVTPMGSRMLKRWLHMPVRDTRV........LL 5 RNLEIT........QNLAGGaeNTLA.SVLDCTVTPMGSRMLKRWLHMPVRHTRV........LL 6 EPLRGQ........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV........ER 7 EPLRGQ........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV........ER 8 RNLELT........QNLAGGteNTLA.SVLDKCVTPMGSRLLKRWIHQPVRDVEK........LK 9 RNLELD........VNLSGGrdNTLQ.SVIDRCQTAMGSRLLGRWLNRPLRDRAV........LE 10 RNLELD........INLSGGreNTLQ.SVVDRCQTAMASRLMSRWLNRPLRDRAV........LE 11 RNLELD........INLSGGreNTLQ.SVVDRCQTAMASRLMSRWLNRPLRDRAV........LE 12 RNLELT........HNLAGGtdNTLA.EVLDHCATPMGSRMLKRWIHQPMRDNAT........LN 13 EPLRGQ........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV........ER 14 RNLEIT........QNLAGGveNTLA.AVLDCTVTPMGSRMLKRWLHMPVRNTDI........LR 15 EPLRGQ........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV........ER 16 ENLSWI........PGDRGKn--LFD.VLNNTETPMGARLGKKWILHPLVDRKQI........EE 17 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQGQRLV........NQ 18 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQGQRLV........NQ 19 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQGQRLV........NQ 20 ENLSLI........PGDRGKn--LFD.VLNNTETPMGARLLKKWILHPLVDRKQI........EE 21 RNLEIN........QTVRDGsfhGSL.LWALDRTSTTMGSRALRRWLLQPLLDLK........GI 22 RNLEIN........QTVRDGsfhGSL.LWALDRTSTTMGSRALRRWLLQPLLDLK........GI 23 SQYMKL........DMAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTAQGQRLV........NQ 24 SQYMKL........DMAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTAQGQRLV........NQ 25 SMANFE........EYIPlds18tka.YQRMVLDAVTLNNLEIFLNGTNGsteGT........LL 26 SMANFE........EYIPlds18tka.YQRMVLDAVTLNNLEIFLNGTNGsteGT........LL 27 SMANFE........EYIPlds18tka.YQRMVLDAVTLNNLEIFLNGTNGsteGT........LL 28 SMANFE........EYIPlds18tka.YQRMVLDAVTLNNLEIFLNGTNGsteGT........LL 29 RNLEIT........QNLAGGveNTLA.AVLDCTVTPMGSRMLKRWLHMPVRNTDI........LR 30 SMANFE........EYFPlds18tka.SQRMVLDAVTLNNLEIFLNGTNGsteGT........LL 31 SQYMKL........DMAAVRALNLFQ.GSVEDttgsQSLAAFLNKCKTAQGQRLV........SQ 32 SMANFE........EYIPlds18tka.YQRMVLDAVTLNNLEIFLNGTNGsteGT........LL 33 SMANFE........EYFPlds18tka.SQRMVLDAVTLNNLEIFLNGTNGsteGN........LL 34 ENARSGkkq.....GSLFWLLDETKT.AMGMRLLRSWIHRPLIDKERIVQRQEVV........QV 35 TNLELL........SPIHGEhgkGSL.LQVMERTSTPMGGRLLRNTLINPFYDLK........EI 36 RNLEIT........QTLSGKksPTLM.STLDLCATHMGSRLLALWLHHPLRNRAH........IR 37 ETIRSKnkk.....GSLLWLLDETKT.AMGGRLLKQWIDRPLIRVNQIEERQEMV........ET 38 RNLEIT........QTLSGKksPTLM.STLDLCATHMGSRLLALWLHHPLRNRAH........IR 39 RHLELD........TRVDGEsrHTLL.GVLDSTVTPMGGRLLRRWLHRPLRLREV........VR 40 VNLELL........APLNDPqgkNSL.LRIMDHTSTPMGGRLLRQILISPFYNPK........EI 41 PESFKQ........LSSGmEFMRING.TTLRNLEILQNQTDMktkGSLLWVLDHT........KT 42 PESFKQ........LSSGmEFMRING.TTLRNLEMVQNQTDMktkGSLLWVLDHT........KT 43 PESFKQ........LSSGmEFMRING.TTLRNLEILQNQTDMktkGSLLWVLDHT........KT 44 KGLEIT........ESIEGRkdLSLF.KVVDRTLTGMGRRRLRFRLLNPFRSIER........IR 45 ETIRSKnkk.....GSLLWLLDETKT.AMGGRLLKQWIDRPLIRVNQIEERQEMV........ET 46 VNLELL........APLNDPqgkNSL.LRIMDHTSTPMGGRLLRQILISPFYNPK........EI 47 TNLELL........SAIHGEhgkGSL.LQVMERTSTPMGGRLLRNTLVNPFYDLK........EI 48 SQYMKL........DNAAVGALNLFP.GSAEDtsgtQSLAGLLNKCKTPQGQRLV........NQ 49 KGLEIL........ESLEGRkdISLF.KVIDRTLTGMGRRRLKFRLLSPFRSREK........IE 50 vksQHS........MVLDGITLQNLE.IFSNSFDGsdkGTLFKLFNRAITPMGKR........MM 51 vksQHS........MVLDGITLQNLE.IFSNSFDGsdkGTLFKLFNRAITPMGKR........MM 52 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQGQRLV........NQ 53 PESFKQ........LSSGmEFMRING.TTLRNLEMVQNQTDMktkGSLLWVLDHT........KT 54 RNLEIV........TNLQGNlyGSVL.NTLNHTVTTQGGRLLYHFLSSPLTNIAK........IN 55 cSMGNF........DEYDAsqqSTSL.LMNGQTLKNLEIFSNSFDGgseGTLFHL........LC 56 KNLEIL........QNLHDSthaHSL.FETLNYTHTAMGTRLLRYWLHHPLRSQE........EI 57 esl10kfe......SLPYCDFSNVNE.KQHMVLDAAALENLEIFENSRNGgysGT........LY 58 ANLELA........KTLSGSrdGSLL.KSLDRTMTSGGARLLAERLMSPLTDPER........IN 59 esl10kfe......SLPYCDFSNVNE.KQHMVLDAAALENLEIFENSRNGgysGT........LY 60 sKPENF........KQLSSKmEFMTI.NGTTLRNLEILQNQTDMktkGSLLWVLD........HT 61 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQGQRLV........NQ 62 RALNVM........ESKTDAnknFSL.FGLMNRTCTaGMGKRLLHMWLKQPLVDL........NE 63 sKPENF........KQLSSKmEFMTI.NGTTLRNLEILQNQTDMktkGSLLWVLD........HT 64 VNLELV........KNNNDFssqYSL.YSVLNDCKTAMGKRLLREFILNPILNIS........EI 65 lSMRNV........TIYNSnsm15dwnGKNLILDGTALENLNIVPNGRDShlTSL........YY 66 ESIRLKskk.....GTLLWLMDETKT.PMGARRLKQWIDRPLISKEQIEARLDIV........DE 67 RFVHLD........SAAVAALNIMPK.PGTHpsmpsyrwQSVLGVLDHCRTPQGH........RL 68 KALNLM........PGARDGaknMSL.YGLLNHCKTPVGSRLLSQWLKQPLMNAE........EI 69 RFVHLD........SAAVAALNIMPK.PGTHpsmpsyrwQSVLGVLDHCRTPQGH........RL 70 vASNFY........QPFDSISSMVLS.KQALEGLELFVNQTDHtpvGSLFWVLDR........TY 71 vASNFY........QPFDSISSMVLS.KQALEGLELFVNQTDHtpvGSLFWVLDR........TY 72 lPMARY........QLYVPpdq16tlrRSHMVLDATTLSNLRII---GEEHSLLS........TL 73 QVmlIP........SIYSPFASKIHM.LLDPNSLQSLDIFTHDGGKGSLFWLLDH........TR 74 GASFRS........LSSNTEMTLSAN.TLQQLEVVKNNSDGsesGSLFHNMNHTL........TV 75 RALNVM........ESKTDAnknFSL.FGLMNRTCTaGMGKRLLHMWLKQPLVDL........NE 76 QVmlIP........SIYSPFASKIHM.LLDPNSLQSLDIFTHDGGKGSLFWLLDH........TR 77 DQvGKY........ELVEHKLKEFMK.LDASAIKALNLFPQGPQNpfg21gkvTS........LF 78 DQvGKY........ELVEHKLKEFMK.LDASAIKALNLFPQGPQNpfg21gkvTS........LF 79 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQGQRLV........NQ 80 MIIGES........AMKGLEIRSSLY.QNrytGSLLHAINKTVTKSGSRLLTRRL........CA 81 MVNLEI........FNNSCDGvlqGP.LNKYLENCVSPTGKRLLRNWICHPLKDV........ES 82 RFVHLD........SAAVAALNIMPK.PGTHpsmpsyrwQSVLGVLDHCRTPQGH........RL 83 RALNIA........EGKTDVnknFSL.FGLMNRTCTvGMGKRLLNRWLKQPLLDV........NE 84 MVNLEI........FNNSCDGgpsGT.LYKYLDNCVSPTGKRLLRNWICHPLKDV........ES 85 meddre........-NtsRKLHLYHH.NLEQYMRLDIAAVRSLNLLPPPNGNahkt.......MS 86 meddre........-NtsRKLHLYHH.NLEQYMRLDIAAVRSLNLLPPPNGNahkt.......MS 87 GASFRS........LSSNTEMTLSAN.TLQQLEVVKNNSDGsesGSLFHNMNHTL........TV 88 LVNLEI........FINNFNGgssGT.LYKHLNHCVTASGKRMLRRWICHPLKDI........DA 89 LVNLEI........FINNFNGgssGT.LYKHLNHCVTASGKRMLRRWICHPLKDI........DA 90 GASFRS........LSSNTEMTLSAN.TLQQLEVVKNNSDGsesGSLFHNMNHTL........TV 91 RQLATA........IMQIDSRTSTAL.ELHSTVRDNnkkGSLLSSIRRTVTPSGT........RL 92 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQGQRLV........NQ 93 RQLATA........IMQIDSRTSTAL.ELHSTVRDNnkkGSLLSSIRRTVTPSGT........RL 94 AVEALE........LFQLNYNYleksnnLTLYNVLNKCKTLPGEKLLRDWLSRPL........CQ 95 HTIPST........FMKLDTAAIQAL.HIIHQKPEArgslpTSVYSWLNRCVTGM........GS 96 SQYMKL........DIAAVRALNLFQ.GSVEDttgsQSLAALLNKCKTPQG----........-- 97 VSIDQD........TYSVLQIFKSES.HPsvy12kegLSLFGILNRCRCKWGQKL........LR 98 VSIDQD........TYSVLQIFKSES.HPsvy12kegLSLFGILNRCRCKWGQKL........LR 99 MIIGES........AMKGLEIRSSLY.QNrytGSLLHAINKTVTKSGSRLLTRRL........CA 100 VEIDFN........TIQALDILPKET.ENkktfgqgRSLYQLMDKCRSTVGKKCL........RK 101 VEIDFN........TIQALDILPKET.ENkktfgqgRSLYQLMDKCRSTVGKKCL........RK 102 AQNLEL........LINNQDYrnnHT.LFGVLNYTKTPGGSRRLRSNILEPLVDI........ET 103 NIDQDT........YSVLQIFKSESH.Psvy12kegLSLFGILNRCHCKWGEKLL........RL 104 AQNLEL........LINNQDYrnnHT.LFGVLNYTKTPGGSRRLRSNILEPLVDI........ET 105 NIDQDT........YSVLQIFKSESH.Psvy12kegLSLFGILNRCHCKWGEKLL........RL 106 NIDQDT........YSVLQIFKSESH.Psvy12kegLSLFGILNRCHCKWGEKLL........RL 107 SKTVRG........LELVENKLDKng.ISLWKFLDTTSTKMGQRSLRNSILQPLT........DR 108 SKTVRG........LELVENKLDKng.ISLWKFLDTTSTKMGQRSLRNSILQPLT........DR 109 VEIDFN........TIQALDILPKET.ENkktfgqgRSLYQLMDKCRSTVGKKCL........RK 110 RAEYQL........DLLSKRGKLGGL.LNLIDYCSTAMGKRLLKFRLLNPITDYS........EL 111 WESLEI........VDADDASkar10kqkRTLMSVLNHTVTTNGYRLLRSSVLQP........ST 112 ENTRTGgls.....GTLYAQLNHCVT.GFGKRLLKRWIAKPLYDCREILRRQSAV........AT 113 ------........------------.----------------------------........-- 114 ------........------------.----------------------------........-- 115 ------........------------.----------------------------........-- 116 RMVLDE........NTISALHIFPTA.HKLghd10ngfFSVFELFNQVSSDYARR........IL 117 SALHIF........PTAHKLghd10ngfFSVFELFNQVSSDYARRILKSWLINPL........TN 118 ------........------------.----------------------------........-- 119 ------........------------.----------------------------........-- 320 330 340 350 | | | | 1 FV.......REGALREGVR...R........LLYRLADLERLATRLE........LGRASPKDLG 2 FV.......REGALREGVR...R........LLYRLADLERLATRLE........LGRASPKDLG 3 ER.......QQTIGALQ--...-........DFTAELQPVLRQVGDL........ERILARLALR 4 ER.......QQTIGALQ--...-........DFTAGLQPVLRQVGDL........ERILARLALR 5 ER.......QQTIGALQ--...-........DFTAELQPVLRQVGDL........ERILARLALR 6 FV.......REGALREGVR...R........LLFRLADLERLATRLE........LSRASPRDLA 7 FV.......REGALREGVR...R........LLFRLADLERLATRLE........LSRASPRDLA 8 QR.......QQSIAEIL-N...F........DLVDELQPYLQLVGDM........ERILARVALR 9 AR.......QDTVACLLQD...-........YRFESLQPQLKEIGDV........ERILARIGLR 10 AR.......QESIACLL-E...R........YRFENLQPQLKEIGDL........ERILARIGLR 11 AR.......QESIACLL-E...R........YRFENLQPQLKEIGDL........ERILARIGLR 12 QR.......LDAITELK-E...T........ALYGELHPVLKQIGDI........ERILARLALR 13 FV.......REGALREGVR...R........LLFRLADLERLATRLE........LSRASPRDLA 14 ER.......QQTIGALQ--...-........DTVSELQPVLRQVGDL........ERTPC----A 15 FV.......REGALREGVR...R........LLFRLADLERLATRLE........LSRASPRDLA 16 RL.......KAVERLVNDR...V........SLEEMRNLLSNVRDVE........RIVSRVEYNR 17 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDAELR........QTLQeDLLRR 18 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDAELR........QTLQeDLLRR 19 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDAELR........QTLQeDLLRR 20 RL.......KAVERLVNDR...V........SLEEMRNLLSNVRDVE........RIVSRVEYNR 21 QA.......RQDTIQELYH...H........PALRQDLRQLLRQIYD........LERLTGRIGA 22 QA.......RQDTIQELYH...H........PALRQDLRQLLRQIYD........LERLTGRIGA 23 WI.......KQPLMDRNRI...E........ERLNLVEAFVEDSELR........QSLQeDLLRR 24 WI.......KQPLMDRNRI...E........ERLNLVEAFVEDSELR........QSLQeDLLRR 25 ER.......VDTCHTPFGK...R........LLKQWLCAPLCNHYAI........NDRLDAIEDL 26 ER.......VDTCHTPFGK...R........LLKQWLCAPLCNHYAI........NDRLDAIEDL 27 ER.......VDTCHTPFGK...R........LLKQWLCAPLCNHYAI........NDRLDAIEDL 28 ER.......VDTCHTPFGK...R........LLKQWLCAPLCNHYAI........NDRLDAIEDL 29 ER.......QQTIGALQ--...-........DTVSELQPVLRQVGDL........ERTPC----A 30 ER.......LDTCHTPFGK...R........LLKQWLCAPLCSPSAI........SDRLDAVEDL 31 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDSELR........RALQeDLLRR 32 ER.......VDTCHTPFGK...R........LLKQWLCAPLCNHYAI........NDRLDAIEDL 33 ER.......LDTCHTPFGK...R........LLKQWLCAPLCSPSAI........SDRLDAVEDL 34 FL.......DHFFERSDLT...D........SLKGVYDIERLASRVS........FGKTNPKDLL 35 TL.......RQDSVEFFLQ...Q........ADLRKILKRQLSCVRD........LERLATKIST 36 AR.......QEAVAALE--...-........SQYKPLQCRLKSIADI........ERIAARIAVG 37 LM.......SHFFEREDLR...E........RLKEVYDLERLAGRVA........FGNVNARDLI 38 AR.......QEAVAALE--...-........SQYKPLQCRLKNIADI........ERIAARIAVG 39 QR.......HAAVGSMI-D...R........DLDNKLMETFRRLGDM........ERILTRVALR 40 LV.......RQDAVEFFLR...Q........VTLRKNIKTYLCQVRD........IERLMTKVTT 41 SF.......GRRKLKNWVT...Q........PLLKLREINARLDAVS........DVLhSESSVF 42 SF.......GRRKLKNWVT...Q........PLLKLREINARLDAVS........DVLhSESSVF 43 SF.......GRRKLKNWVT...Q........PLLKLREINARLDAVS........DVLhSESSVF 44 KV.......QEAVEELINK...R........EVLNEIRKTLEGMSDL........ERLVSRISSN 45 LM.......SHFFEREDLR...E........RLKEVYDLERLAGRVA........FGNVNARDLI 46 LV.......RQDAVEFFLR...Q........VTLRKNIKTYLCQVRD........IERLMTKVTT 47 TL.......RQDSVEFFLK...Q........EPLRKTLKRHLSCVRD........LERLATKIST 48 WI.......KQPLMDKNRV...E........ERLNLVEAFVMDVELR........QCLQeDLLRR 49 RI.......QEGVQELKEN...R........EALLKIRQILEGMADL........ERLVSKISSN 50 KK.......WLMHPLLRKN...D........IESRLDSVDSLLQDIT........LREQLEITFS 51 KK.......WLMHPLLRKN...D........IESRLDSVDSLLQDIT........LREQLEITFS 52 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDAELR........QTLQeDLLRR 53 SF.......GRRKLKNWVT...Q........PLLKLREINARLDAVS........DVLhSESSVF 54 HR.......LNITEFFYSN...L........GIVTRIRELLKNTSDI........ERCLTRITMN 55 RC.......VTPFGKRLFH...T........WLCHPLRSGTAINARL........DVVELIADNP 56 QK.......RLSAVVFFHH...R........PHILKTLRATLSCVRD........VERLVARVAL 57 AQ.......LNQCITASGK...R........LLKTWLARPLYNTELI........KERQDAVAIL 58 QR.......LDSIEVLADQ...P........RFTTDVRDALRRAPDM........PRALSRLALG 59 AQ.......LNQCITASGK...R........LLKTWLARPLYNTELI........KERQDAVAIL 60 KT.......SFGRRKLKKW...V........TQPLLKLREINARLDA........VSEVLhSESS 61 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDAELR........QTLQeDLLRR 62 IK.......TRLDIVQCFV...E........EAGLRQDLRQHLKRIS........DVERLLRSLE 63 KT.......SFGRRKLKKW...V........TQPLLKLREINARLDA........VSEVLhSESS 64 NT.......RLDHVEFFCK...N........ISLTVTLRETFINIWD........IERIISRIQM 65 VI.......NKCSTPFGRR...L........LRSWLLQPTCDPKKLE........QRQKAIKWLV 66 FS.......AHFIERDTLR...T........YLNQVYDIERLVGRVS........YGNVNARDLI 67 MG.......QWVKQPLRSR...N........ILNDRHNIVQCLLESP........DTMETLSlDY 68 EK.......RQQLVEAFAN...D........TELRQSMQeEHLRSIP........DLYRLSKRFQ 69 MG.......QWVKQPLRSR...N........ILNDRHNIVQCLLESP........DTMETLSlDY 70 TR.......FGQRMLQRWL...Q........KPLVDKENIIERLDAV........EELAfNSNSQ 71 TR.......FGQRMLQRWL...Q........KPLVDKENIIERLDAV........EELAfNSNSQ 72 DH.......CCTKFGKRLL...H........HWLCAPSCDVSVIKER........QDAIGELIRM 73 TS.......FGLRMLREWI...L........KPLVDVHQIEERLDAI........ECITseiNNS 74 YG.......SRLLRHWVTH...P........LCDRNLISARLDAVsei.......16qlsSELVE 75 IK.......TRLDIVQCFV...E........EAGLRQDLRQHLKRIS........DVERLLRSLE 76 TS.......FGLRMLREWI...L........KPLVDVHQIEERLDAI........ECITseiNNS 77 QL.......LNHCKTNAGV...R........LLNEWLKQPLTNIDEI........NKRHDLVDYL 78 QL.......LNHCKTNAGV...R........LLNEWLKQPLTNIDEI........NKRHDLVDYL 79 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDAELR........QTLQeDLLRR 80 PS.......TNIVEINNRL...D........LVEKFKLLPELCSKVI........NLLKKSNDTH 81 IN.......KRLDVVEEFT...A........NSESMQITGQYLHKLP........DLERLLGRIK 82 MG.......QWVKQPLRSR...N........ILNDRHNIVQCLLESP........DTMETLSlDY 83 IN.......NRLDMVQAFV...E........DPELRQGLRQQLKRIS........DIDRLTHSLR 84 IN.......KRLDVVEEFT...A........NSESMQITGQYLHKLP........DLERLLGRIK 85 LY.......GLLNHCRTAM...G........ARNLRRWIVQPLLDAK........SIERRHDLVS 86 LY.......GLLNHCRTAM...G........ARNLRRWIVQPLLDAK........SIERRHDLVS 87 YG.......SRLLRHWVTH...P........LCDRNLISARLDAVsei.......16qlsSELVE 88 IN.......KRLDVVEGFI...Q........NCGLGPTTLGYLQKIP........DLERLLGQVR 89 IN.......KRLDVVEGFI...Q........NCGLGPTTLGYLQKIP........DLERLLGQVR 90 YG.......SRLLRHWVTH...P........LCDRNLISARLDAVsei.......16qlsSELVE 91 LS.......QWLSGPSLDL...K........EIKKRQKIVAFFKDNR........DITENLRTML 92 WI.......KQPLMDKNRI...E........ERLNLVEAFVEDAELR........QTLQ------ 93 LS.......QWLSGPSLDL...K........EIKKRQKIVAFFKDNR........DITETLRTML 94 ID.......HINERLDIVE...A........LFENQTIRQKLRdSIL........ARMPDCSQLA 95 RM.......MRQWLLQPLR...N........AEDINQRLSLVELMVE........DSILRDALLs 96 --.......----------...-........----------------........---------- 97 LW.......FTRPTRELRE...L........NSRLDVIQFFLmpQNL........DMAQMLHRLL 98 LW.......FTRPTRELRE...L........NSRLDVIQFFLmpQNL........DMAQMLHRLL 99 PS.......TNIVEINNRL...D........LVEKFKLLPELCSKVI........NLLKKSNDTH 100 WF.......RNPTTDRDDL...V........SRQKCVHYFKqdWNAE........VTAKLSSILG 101 WF.......RNPTTDRDDL...V........SRQKCVHYFKqdWNAE........VTAKLSSILG 102 IN.......MRLDCVQELL...Q........DEELFFGLQSVISRFL........DTEQLLSVLV 103 WF.......TRPTHDLGEL...S........SRLDVIQFFLlpQNLD........MAQMLHRLLG 104 IN.......MRLDCVQELL...Q........DEELFFGLQSVISRFL........DTEQLLSVLV 105 WF.......TRPTHDLGEL...S........SRLDVIQFFLlpQNLD........MAQMLHRLLG 106 WF.......TRPTHDLGEL...S........SRLDVIQFFLlpQNLD........MAQMLHRLLG 107 GS.......IEMRLEALEE...L........KANDDLLQKLRLEMKS........LPDLDKLFSR 108 GS.......IEMRLEALEE...L........KANDDLLQKLRLEMKS........LPDLDKLFSR 109 WF.......RNPTTDRDDL...V........SRQKCVHYFKqviifkv.......EYRNLWEIFL 110 NL.......RYKDISIFKR...L........LNQKIFDNSELKCIKD........LSSLHRQWAi 111 DV.......YLIQSRQEAI...E........ELIGKPQLKDKLRRTL........SRAHELDRVI 112 FKg......VGQDCAAQFR...K........DLSRLPDMERLLARLFssc.....14vvlYEDAS 113 --.......----------...-........----------------........---------- 114 --.......---GIGVDVS...P........VMIKVVDAAVQKARIG........LRNARPRDLA 115 --.......----------...-........----------------........---------- 116 KS.......WLINPLTNKK...R........IETRYSIIRTLLdkQN........AIIFSDLSQS 117 KK.......RIETRYSIIR...T........LLdkQNAIIFSDLSQS........IKRCPDAFGF 118 --.......----------...-........----------------........---------- 119 --.......----------...-........----------------........---------- 360 370 380 390 4 | | | | 1 AL.RRSLQILPELRALLGEEVG........LPDLSPLKEELEAALVEDPP........LKVSEGG 2 AL.RRSLQILPELRALLGEEVG........LPDLSPLKEELEAALVEDPP........LKVSEGG 3 TA.RPRDLARMRHAFQQLPELR........AQLETVDSapv9lrekMGEF........AELRDLL 4 TA.RPRDLARMRHAFQQLPELR........AQLETVDSapv9lrekMGEF........AELRDLL 5 TA.RPRDLARMRHAFQQLPELR........AQLETVDSapv9lrekMGEF........AELRDLL 6 AL.RRSLEILPELKGLLGEEVG........LPDLSGLLEELRAALVEDPP........LKVSEGG 7 AL.RRSLEILPELKGLLGEEVG........LPDLSGLLEELRAALVEDPP........LKVSEGG 8 SA.RPRDLTRLRTALEQIPALR........AIVQQKTPpfl9lfsqIADF........SEQCDLL 9 NA.RPRDLARLRDALAALPQLQ........TALSPLEAphl9lagnIRTY........PELAELL 10 NA.RPRDLARLRDALAALPDLQ........NAMTELEAphl9lattIGTY........PELAELL 11 NA.RPRDLARLRDALAALPDLQ........NAMTELEAphl9lattIGTY........PELAELL 12 SA.RPRDLARLRHAMQQLPELH........SVMSELKQphl9lrthAEPM........DELCDLL 13 AL.RRSLEILPELKGLLGEEVG........LPDLSGLLEELRAALVEDPP........LKVSEGG 14 SG.AAQPSARSRPNASRLPAAA........ELHAQLETvds12rkkMGDF........AELRDLL 15 ALrRRSLEILPELEGLLGEEVG........LPDLSGLLEELRAALVEDPP........LKVSEGG 16 SV.PRDLVALRETLEIIPKLNE........VLSTFGVfkkLAFPEGLVDL........LRKAIED 17 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPNVIQALEKH........EGkhq17 18 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPNVIQALEKH........EGkhq17 19 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPNVIQALEKH........EGkhq17 20 SV.PRDLVALRETLEIIPKLNE........VLSTFGVfkkLAFPEGLVDL........LRKAIED 21 NT.ASARDVYGLASSLVRLTDL........AELAQEGHSpyl9lqtvPPE........LEELGKY 22 NT.ASARDVYGLASSLVRLTDL........AELAQEGHSpyl9lqtvPPE........LEELGKY 23 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPSVIQALEKY........EGrhq17 24 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPSVIQALEKY........EGrhq17 25 MV.VPDKISEVVELLKKLPDLE........RLLSKIHnvg23ettYSKKK........IIDFLSA 26 MV.VPDKISEVVELLKKLPDLE........RLLSKIHnvg23ettYSKKK........IIDFLSA 27 MV.VPDKISEVVELLKKLPDLE........RLLSKIHnvg23ettYSKKK........IIDFLSA 28 MV.VPDKISEVVELLKKLPDLE........RLLSKIHnvg23ettYSKKK........IIDFLSA 29 SG.AAQPSARSRPNASRLPAAA........ELHAQLETvds11cvkKWAI........SPSCATS 30 MA.VPDKVTEVADLLKKLPDLE........RLLSKIHnvg23ettYSKKK........IIDFLSA 31 FP.DLNRLAKKFQRQAANLQDC........YRLYQGVKQLPNVIQALEKY........QGrhq17 32 MV.VPDKISEVVELLKKLPDLE........RLLSKIHnvg23ettYSKKK........IIDFLSA 33 MA.VPYKVTEVADLLKKLPDLE........RLLSKIHnvg23ettYSKKK........IIDFLSA 34 QL.ATTLSSVPRIRAILEGMEQptl.....9liaqLDAIPELESLISAAI........APEAPHV 35 SL.ATPKDIGTLRDSLLSCTHI........ADNLQNCALpef10fliAPP........LCSLIKT 36 NA.RPRDLAALRDSLFALSEIE........LSAECSSLlgtlkavFPENL........STAEQLR 37 QL.KESLKQVPGIKQLVASLAHdka.....9rakrIDPCGDVLELLEEAL........YENPPLS 38 NA.RPRDLASLRDSLFELAQID........LSANGSSLletlkavFPENL........STAEQLR 39 SA.RPRDISTLRDSLSLLPRLR........ELLNASDSprl9lyaeLGEH........DSTASLL 40 GL.AGPRDIGTLRDSFSAGAQI........YEQLASATLpef10cslDTK........LASLIAL 41 EQ.IENLLRKLPDVERGLCSIY........HKKCSTQEFFLIVKSLCQLK........SELQALM 42 EQ.IENLLRKLPDVERGLCSIY........HKKCSTQEFFLIVKSLCQLK........SELQALM 43 EQ.IENLLRKLPDVERGLCSIY........HKKCSTQEFFLIVKSLCQLK........SELQALM 44 MA.SPRELIHLKNSLRKAEELR........KILSLLDSeif9iegsLLNL........NKVADLI 45 QL.KESLKQVPGIKQLVASLAHdka.....9rakrIDPCGDVLELLEEAL........YENPPLS 46 GL.AGPRDIGTLRDSFSAGAQI........YEQLASATLpef10cslDTK........LASLIAL 47 TL.ASPKDIGMLRDSLLSCMHI........AHDLQSYTLpef10cliSSS........LKSLIEA 48 FP.DLNRLAKKFQRQTANLQDC........YRLYQAVNHLPTVVQAIEKY........EGthq17 49 MA.TPRELVYLKNSLKKVEELR........LLLLELKApif9ilqnFEDT........KKIINDI 50 KL.PDLERMLARIHSRTIKVKD........FEKVITAFETIIELQDSLKN........NDLKGDV 51 KL.PDLERMLARIHSRTIKVKD........FEKVITAFETIIELQDSLKN........NDLKGDV 52 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPNVIQALEKH........EGkhq17 53 EQ.IENLLRKLPDVERGLCSIY........HKKCSTQEFFLIVKSLCQLK........SELQALM 54 RS.SGRDLLSIKYTLETAKTIK........GLFSESYGlnl13ikpLSGD........AELYNLI 55 VI.RDTIWGFLHKLPDLERLIS........RVHAGRSKPADFVRVLEGFQ........RINSAFD 56 EK.AHGRDLLALKESLRAILTF........RSLERESPFppd10egdTPV........LQELYGL 57 Rg.ENLPYSLEFRKSLSRLPDM........ERLIARMFssi18yedTAKK........QVQEFIS 58 RG.GPRDLGAIQAGMRAAAAIS........ALLSGAELsae11daiAALP........GELLARL 59 Rg.ENLPYSLEFRKSLSRLPDM........ERLIARMFssi18yedTAKK........QVQEFIS 60 VF.GQIENHLRKLPDIERGLCS........IYHKKCSTQEFFLIVKTLYH........LKSEFQA 61 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPNVIQALEKH........EGkhq17 62 RR.RGGLQHIIKLYQSAIRLPF........IKTAMQQYTGefa19lsdQD........HLGKFID 63 VF.GQIENHLRKLPDIGRGLCS........IYHKKCSTQEFFLIVKTLYH........LKSEFQA 64 KR.YIKKDFLFIEKALSVFFTV........KKLFDKHNFdywNFDKFEED........SISKVYF 65 sp.DASSFMTTATATLKKIPDL........DRLLQKIHtig23tikTNQK........KIAELLA 66 QL.KHSISEIPNIKALLNSMNQntlvqvnqLEPLDDLLDILEQSLVEEPP........ISVKDGG 67 LK.RIPDILMLTKKLMRRKANL........QDLFRIYQVILRTPKILKVL........HELDNst 68 RG.KATLEDVVRAYQVVIRLPG........FIGTLEGVMDeay18relSD........SLVKLQE 69 LK.RIPDILMLTKKLMRRKANL........QDLFRIYQVILRTPKILKVL........HELDNst 70 VQ.AIRKMLYRLPDLEKGLSRI........Yyqr13afsKNSYSCFKSAL........LRRLIQQ 71 VQ.AIRKMLYRLPDLEKGLSRI........Yyqr13afsKNSYSCFKSAL........LRRLIQQ 72 PT.ELQEVRALLAPMPDFERNL........AQIHlfg24eklYNKQKLQG........FMAVLKG 73 IF.FESLNQMLNHTPDLLRTLN........RIMYGTTSRKEVYFYLKQIT........SFVDHFK 74 EG.SERAIVSPefy11vltAMS........RSSDIQRGITRIFHRTAKAT........EFIAVME 75 RR.RGGLQHIIKLYQSTIRLPF........IKTAMQQYTGefa19lsdQD........HLGKFID 76 IF.FESLNQMLNHTPDLLRTLN........RIMYGTTSRKEVYFYLKQIT........SFVDHFK 77 ID.QIELRQMLTsEYLPMIPDI........RRLTKKLN-KRGNLEDVLKI........YQFSKRI 78 ID.QIELRQMLTsEYLPMIPDI........RRLTKKLN-KRGNLEDVLKI........YQFSKRI 79 FP.DLNRLAKKFQRQAANLQDC........YRLYQGINQLPNVIQALEK-........------- 80 RI.LQHLLMGRGNSYDLLKMAD........NFSITKEIHSLLSPLESssa........10llnMH 81 SS.VRSSASVLPALLGKKVLKQ........RVKAFGQIVKgfr11llaLQ........KESNMMS 82 LK.RL-----------------........--------------------........------- 83 KK.SANLQPVVKLYQSCSRIPY........IKGILQQYNGqfs19wmaKN........RFGRFSS 84 SS.VRSSASVLPALLGKKVLKQ........RVKAFGQIVKgfr11llaLQ........KESNMMS 85 AL.VEDAEARQLLLdddHLLRS........IPDIPKLCRRLTRGSASLED........VVRIYQM 86 AL.VEDAEARQLLLdddHLLRS........IPDIPKLCRRLTRGSASLED........VVRIYQM 87 EG.SERAIVSPefy11vltAMS........RSSDIQRGITRIFhrt23vpg.......SSSPGLR 88 --.--STVGLSSLLQLPFIGEK........IIK-----------------........------- 89 --.--STVGLSSLLQLPFIGEK........IIK-----------------........------- 90 EG.SERAIVSPefy11vltAMS........RSSDIQRGITRIFhrt23vpv.......SSSPGLR 91 KK.VNDLSRILQKFSFGRGEAL........ELIQMARSLEVSREIRKYLL........NNTSlmk 92 --.-------------------........--------------------........------- 93 KK.VNDLSRILQKFSFGRGEAL........ELIQMARSLEVSREIRKYLL........NNTSlmk 94 RR.LM-RKCTLQDLNRFYQAAT........LLETVEMQLIQLSEaeq18ite......ILKKVER 95 QV.LRCCGDMDRLNRKLQRRSI........ALKDLQSILTFVNTIPRAVQ........VLRTHQG 96 --.-------------------........--------------------........------- 97 SH.IKNVPLILKRMKLSHTKVS........DWQVLYKTVYSALGLRDACR........SLPQsiq 98 SH.IKNVPLILKRMKLSHTKVS........DWQVLYKTVYSALGLRDACR........SLPQsiq 99 RI.LQHLLMGRGNSYDLLKMAD........NFSITKEIHSLLSPLESssa........10llnMH 100 RV.KALNSVFQKFQSGTAQLIH........WECFVSTVNALVEILNIIRQ........TPIske9 101 RV.KALNSVFQKFQSGTAQLIH........WECFVSTVNALVEILNIIRQ........TPIske9 102 qip9dtvnAAESKITNLIYLKH........TLELVDPLKIAMKNCNTpll........11sleDK 103 HI.KNVPLILKRMKLSHTKVSD........WQVLYKTVYSALGLRDACRS........LPQsiq1 104 qip9dtvnAAESKITNLIYLKH........TLELVDPLKIAMKNCNTpll........11sleDK 105 HI.KNVPLILKRMKLSHTKVSD........WQVLYKTVYSALGLRDACRS........LPQsiq1 106 HI.KNVPLILKRMKLSHTKVSD........WQVLYKTVYSALGLRDACRS........LPQsiq1 107 LLcinhsaiKPDQRINYVLLLK........ETLQSVKSLKDALNDQLIqsr.......13ifnND 108 LLcinhsaiKPDQRINYVLLLK........ETLQSVKSLKDALNDQLIqsr.......13ifnND 109 NH.SKFSPDSEYLSEKIFlkk9........6kfqSGTAQLIHWECFVSTV........NALVEIL 110 cassDTTLPPKKLSQIYHSYLF........ACQLISKLTNNIQlpplvGP........QLKSLIK 111 AM.CIqts9wtvrESEAKINQI........IKLMHTLKVIQGIRTLLHSA........KMksn13 112 KK.LLQQFTSALCGCQQMFHAC........SSISTlic18gkgLSNISSI........LDRFRDA 113 --.-------------------........--------------------........------- 114 RL.RDALGALPELQNAMTELEAphl.....9laaiTGTYPELASLLERAI........IDNPPAV 115 --.-------------------........--------------------........------- 116 IK.RCPDAFGFINQLRSGKSTL........GTWSKVASFLEKGIAIFQLV........SSLKLgs 117 IN.QLRSGKSTLGTWSKVASFL........EKGIAIFQLVSSLKLgsd16kvd.....ISALKEC 118 --.-------------------........--------------------........------- 119 --.-------------------........--------------------........------- 00 410 420 430 440 450 | | | | | | 1 LIREGYDPDLDALR.AAHREGVAYFLELEERERERTG..IP........TLKVGYNAVFGYYLEV 2 LIREGYDPDLDALR.AAHREGVAYFLELEERERERTG..IP........TLKVGYNAVFGYYLEV 3 ERAIIDTPPVLVRD.GGVIASGYNEELDEWRALADGA..TD........YLERLEVRERERTGLD 4 ERAIIDTPPVLVRD.GGVIASGYNEELDEWRALADGA..TD........YLERLEVRERERTGLD 5 ERAIIDTPPVLVRD.GGVIASGYNEELDEWRALADGA..TD........YLERLEVRERERTGLD 6 LIREGYDPDLDALR.RAHAEGVAYFLDLEAREKERTG..IP........TLKVGYNAVFGYYLEV 7 LIREGYDPDLDALR.RAHAEGVAYFLDLEAREKERTG..IP........TLKVGYNAVFGYYLEV 8 QRALIETPPLLIRD.GGVIAEGYNAELDEWRMLSDGA..TQ........YLENLEKRERESTGID 9 RRAIIDNPPAVIRD.GGVLKQGYDAELDELLSLSENA..GQ........FLMDLEAREKARTGLP 10 AKAIIDNPPAVIRD.GGVIKTGYDAELDELQALSENA..GQ........FLMDLEAREKARTGLP 11 AKAIIDNPPAVIRD.GGVIKTGYDAELDELQALSENA..GQ........FLMDLEAREKARTGLP 12 ERAIKENPPVVIRD.GGVIADGYSAELDEWRDLANGA..TE........FLERLEAEERDRHGID 13 LIREGYDPDLDALR.RAHAEGVAYFLDLEAREKERTG..IP........TLKVGYNAVFGYYLEV 14 ERAIIDAPPVLVRD.GAVIAPGYHEELDEWRALADGA..TD........YLDRLEIRERERTGLD 15 VIREGYDPDLDALR.RAHADPVAYFLDLEVREKESTG..IP........TLKVGYNAVFGYYLEV 16 DPVGSPGEGKVIKR.GFSSELDEYRDLLEHAEERLKE..FE........EKERERTGIQKLRVGY 17 tdlRSDFSKFQEMI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELREIMNDLEKKM 18 tdlRSDFSKFQEMI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELREIMNDLEKKM 19 tdlRSDFSKFQEMI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELREIMNDLEKKM 20 DPVGSPGEGKVIKR.GFSSELDEYRDLLEHAEERLKE..FE........EKERERTGIQKLRVGY 21 VLAHIVENPPLHIR.EGNLIRSGVNPTLDEMRQSLED..DN........QWLANLEVTEREKTGI 22 VLAHIVENPPLHIR.EGNLIRSGVNPTLDEMRQSLED..DN........QWLANLEVTEREKTGI 23 idlRSDFSKFQEMI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELREVMDGLEKKM 24 idlRSDFSKFQEMI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELREVMDGLEKKM 25 LEGFKVMCKIIGIM.EEVADgfk21egrFPDLTVELN..RW........DTAFDHEK-ARKTGLI 26 LEGFKVMCKIIGIM.EEVADgfk21egrFPDLTVELN..RW........DTAFDHEK-ARKTGLI 27 LEGFKVMCKIIGIM.EEVADgfk21egrFPDLTVELN..RW........DTAFDHEK-ARKTGLI 28 LEGFKVMCKIIGIM.EEVADgfk21egrFPDLTVELN..RW........DTAFDHEK-ARKTGLI 29 WNAPLLTRRRYWSR.RRVIAPGYHEELDEWRALADGA..TD........YLDRLEIRERERTGLD 30 LEGFKVMCKVSGLL.EEVAGgft21kgrFPDLTAELQ..RW........DTAFDHEK-ARKTGLI 31 tdlRSDFSKFQEKI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELREVMDGLEKKM 32 LEGFKVMCKIIGIM.EEVADgfk21egrFPDLTVELN..RW........DTAFDHEK-ARKTGLI 33 LEGFKVMCKVSGLL.EEVAGgft21kgrFPDLTAELQ..RW........DTAFDHEK-ARKTGLI 34 ITDGGIIRTGFDET.LDKYRCVLREGTSWIAEIEAKE..RE........NSGISTLKIDYNKKDG 35 LSTELIQELPLKVS.EGNIFANHYHPDLLRLRNIKEN..SK........SWILEYQERIRNETGI 36 QAILPEPSVWLKDG.NVINHGFHPELDELRRIQNHGD..EF........LLDLEAKERERTGLST 37 VKEGNLIKDGYNQK.LDEYRDASRNGKDWIARLEQQE..RE........YTGIRSLKVGFNKVFG 38 QAILPEPSVWLKDG.NVINHGFHPELDELRRIQNHGD..EF........LLDLEAKERERTGLST 39 VKAVAEQPPLKLTD.GGVIASEYDVELDELRKLSNNA..DQ........FLIDLETRERESSGIS 40 LSKSLNGDLPLRVS.DGNIFVDEFHNDLKRLRHNQEH..SQ........EWIWEYQERIRKETGI 41 PAVNshv11ralIV.ELLSPVEHYLKVLNGPAAKVGD..KT........ELFKDLSDFPLIKKRk 42 PAVNshv11ralIV.ELLSPVEHYLKVLNGPAAKVGD..KT........ELFKDLSDFPLIKKRk 43 PAVNshv11ralIV.ELLSPVEHYLKVLNGPAAKVGD..KT........ELFKDLSDFPLIKKRk 44 DKTLVDDPPLHVKE.GGLIKPGVNAYLDELRFIRENA..EK........LLKEYEKKLKKETGIQ 45 VKEGNLIKDGYNQK.LDEYRDASRNGKDWIARLEQQE..RE........YTGIRSLKVGFNKVFG 46 LSKSLNGDLPLRVS.DGNIFVDEFHNDLKRLRHNQEH..SQ........EWIWEYQERIRKETGI 47 LSTDLLQELPLKVS.EGNIFADHYHQDLLRLRNIKTN..SK........SWILEYQERIRQETGI 48 sdlSSDFSKFQEMI.ETTLDMD--QVENHEFLVKASF..DP........NLTELREKMDELEKNM 49 EKTLVEDPPLHVKE.GGLIREGVNAYLDELRFIRDNA..ET........YLREYEKKLRQETGIQ 50 SKYISSFPEGLVEA.VKswt10rqkAINENIIVPQRG..FD........IEFDKSMDRIQELEDE 51 SKYISSFPEGLVEA.VKswt10rqkAINENIIVPQRG..FD........IEFDKSMDRIQELEDE 52 tdlRSDFSKFQEMI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELREIMNDLEKKM 53 PAVNshv11ralIV.ELLSPVEHYLKVLNGPAAKVGD..KT........ELFKDLSDFPLIKKRk 54 HMSIREDAPNNLND.GGIIKYEFHPKIAQLNDLINNK..KL........HVEKLKDQYRKETRIE 55 QLREEFMeva14iqsAPNMKEELEAWTRAFNWQK-AS..EE........GVFEPEIGFEAEYDTS 56 LEQSIKEDCPVTLS.DGNLIKRGFSASLDELHRVRDN..AN........EILKQYLAEERERTGI 57 TLRGCETMAEACSS.LRAILKhdt16gqsLPNISSSI..KY........FKDAFDWVE-AHNSGR 58 DATLAEELPLLKRD.GGFVREGASAELDEMRALRDQS..RR........VIAGLQLQYCEETGIK 59 TLRGCETMAEACSS.LRAILKhdt41gqsLPNISSSI..KY........FKDAFDWVE-AHNSGR 60 IIPAVNshi14ile.IPELLSPVEHYLKILNEQAAKV..GD........KTELFKDLSDFPLIKK 61 tdlRSDFSKFQEMI.ETTLDMD--QVENHEFLVKPSF..DP........NLSELK---------- 62 LVECSVDLD--QLE.NGEYMISSNYDTKLASLKDQKE..LL........EQQIHELHKKTAIELD 63 IIPAVNshi14ile.IPELLSPVEHYLKILNEQAAKV..GD........KTELFKDLSDFPLIKK 64 LINSAISSAPDELI.KRGYDLKLDNLKDLKINANKYI..DQ........YLESERLLSKINNLKI 65 AIDGFKLCNKLRKE.YIKVQKege17eqeMEEVDENI..YF........FEKMFDRST-AMKDGK 66 LFKVGFNTQLDE--.----------------------..--........---------------- 67 i14ksfLKDLTGLK.QMVEQVVDFE--AIERGEYLVK..AS........FDSRLMELQQMMTELY 68 MVETTVDLD--ALD.NHEFIIKPEFDDSLRIIRKKLD..RL........RTDMDNEFAEAAEDLG 69 i14ksfLKDLTGLK.QMVEQVVDFE--AIERGEYLVK..AS........FDSRLMELQQMMTELY 70 LPSISSIIDHFLGmfDQKEAENNNKVDMFKDIDNFDL..SE........EPNDVDYELAQEIREL 71 LPSISSIIDHFLGmfDQKEAENNNKVDMFKDIDNFDL..SE........EPNDVDYELAQEIREL 72 FNDLTKLPTMFHQC.KTtll15ggsFPDLSKELQYFA..TA........FDHDA-AAKTGVIAPQ 73 MHQSYLSehf32ttqLPHFLTMINVSAVMEKNSDKQV..MD........FFNLNNYDCSEGIIKI 74 AILLAGKQIQRLGI.KQDsem28pvvVDNAGKLLSAL..NK........EAAVRGDLL--DILIT 75 LVECSVDLD--QLE.NGEYMISSSYDTKLASLKDQKE..LL........EQQIHELHKKTAIELD 76 MHQSYLSehf32ttqLPHFLTMINVSAVMEKNSDKQV..MD........FFNLNNYDCSEGIIKI 77 PEIVQVFTSFLEdds23shhVEPLSKFEEMVETTVDL..DA........-YEENNEFMIKVEFNE 78 PEIVQVFTSFLEdds23shhVEPLSKFEEMVETTVDL..DA........-YEENNEFMIKVEFNE 79 --------------.----------------------..--........---------------- 80 PHDELKQLINNAVD.ENALmkqkINEEEETEVIAQEA..EE........ILQDENAQVEIVKKSL 81 LLYKLCKLPILVGK.SGLELFLSQFEAAID-------..--........---------------- 82 -----KQMVEQVVD.FE--AIERGEYLVKASFDSRLM..EL........QQMMTELYSKMEELQF 83 LVETAIDLA--QLE.NGEYRISPLYSSDLGVLKDELS..VV........ENHINNLHVDTASDLD 84 LLYKLCKLPILVGK.SGLELFLSQFEAAID-------..--........---------------- 85 AKALPKIVTVLDSL.TSehk17nnhCKNLEKLIELVE..TT........IDLE--ALDSHQYIIR 86 AKALPKIVTVLDSL.TSehk17nnhCKNLEKLIELVE..TT........IDLE--ALDSHQYIIR 87 VLNFLDEKFIAVME.AILLAGKQIQrlg35pvvVDNA..GK........LLSALNKEAAVRGDLL 88 ---KRIKTFIMLIN.GLRNGIDLLNDLQRADHGILA-..--........--LYKIVDIPSLSY-- 89 ---KRIKTFIMLIN.GLRNGIDLLNDLQRADHGILA-..--........--LYKIVDIPSLSY-- 90 VLNFLDEKFIAVME.AILLAGKQIQrlg35pvvVDNA..GK........LLSALNKEAAVRGDLL 91 9lksqITQLTESLN.FEKNLIDDILKFLNEEELAKSQ..DA........KQNADVTRMLDIDVKD 92 --------------.----------------------..--........---------------- 93 9lksqITQLTESLN.FEKNLIDDILKFLNEEELAKSQ..DA........KQNADVTRMLDIDVKD 94 FQVLCDEFFDFDYE.KENKEIRVRVDFVPEIQEISEK..LE........QMERVAEKLRKKYSAK 95 grn14iapLEDINE.HFSNLRILITATVDLSDENTTR..IN........PEFDDELMELEEQRKS 96 --------------.----------------------..--........---------------- 97 12qefSDDLHHIAS.LIGKVVDFEE-SLAENRFTVLP..NI........DPDIDAKKRRLIGLPS 98 12qefSDDLHHIAS.LIGKVVDFEE-SLAENRFTVLP..NI........DPDIDAKKRRLIGLPS 99 PHDELKQLINNAVD.ENALmkqkINEEEETEVIAQEA..EE........ILQDENAQVEIVKKSL 100 vesdLLREVSEIAV.IAGSIINFAESKIQGRVTVMNG..ID........EELDEIRDTYENMPMV 101 vesdLLREVSEIAV.IAGSIINFAESKIQGRVTVMNG..ID........EELDEIRDTYENMPMV 102 RFGIILEKIKTVIN.DDARymkgclnMRTQKCYAVRS..NI........NEFLDIARRTYTEIVD 103 2qefSDDLHHIASL.IGKVVDFEG-SLAENRFTVLPN..ID........PEIDEKKRRLMGLPSF 104 RFGIILEKIKTVIN.DDARymkgclnMRTQKCYAVRS..NI........NEFLDIARRTYTEIVD 105 2qefSDDLHHIASL.IGKVVDFEG-SLAENRFTVLPN..ID........PEIDEKKRRLMGLPSF 106 2qefSDDLHHIASL.IGKVVDFEG-SLAENRFTVLPN..ID........PEIDEKKRRLMGLPSF 107 AIMEIEKLINSCIN.EDCVwassaiqLLNQRSYAVKS..DS........NGLLDVSRQIYKEVKE 108 AIMEIEKLINSCIN.EDCVwassaiqLLNQRSYAVKS..DS........NGLLDVSRQIYKEVKE 109 NIIRQTPIske9vesdLLREVSEIAVIAGSIINFAES..KI........QGRVTVMNGIDEELDE 110 EIERIFQVDSLLGD.FKDVIQPIGNLPNLFEQRQTLR..--........-AQLTEWAEQISNIVF 111 flkDPRFDQIMNIL.VEKVDDSLLdgkknslhLQNTK..CY........AIRHFVAVQLDLARQT 112 FDWSD-ADRNGRFI.PYEGCDPEFDATCNAIEEIKSS..LK........EYLKEQRKLLRPASVN 113 --------------.----------------------..--........---------------- 114 IRDGGVLKAGYDNE.LDEMLAISENAGQFLIDLEARE..KA........RTGLANLKVGYNRVHG 115 --------------.----------------------..--........---------------- 116 d16kvdISALKECL.RKVETVIDFDT-SRDTKTLTIN..TG........VDNRLDECRNIYNHLE 117 LRKVETVIDFDT-S.RDTKTLTINTGVDNRLDECRNI..YN........HLEGILLDVARETQIF 118 --------------.----------------------..--........---------------- 119 --------------.----------------------..--........---------------- 460 470 480 490 500 | | | | | 1 TRPYY....ER....VPKE......YRPVQTLKD...RQRYTLPEMKEKEREVYRLEALIRRREE 2 TRPYY....ER....VPKE......YRPVQTLKD...RQRYTLPEMKEKEREVYRLEALIRRREE 3 TLKVG....FN....AVHG......YYIQISRGQ...SHLAPINYMRRQTLKNAERYIIPELKEY 4 TLKVG....FN....AVHG......YYIQISRGQ...SHLAPINYMRRQTLKNAERYIIPELKEY 5 TLKVG....FN....AVHG......YYIQISRGQ...SHLAPINYMRRQTLKNAERYIIPELKEY 6 TRPYY....EK....VPQE......YRPVQTLKD...RQRYTLPEMKERERELYRLEALIKRREE 7 TRPYY....EK....VPQE......YRPVQTLKD...RQRYTLPEMKERERELYRLEALIKRREE 8 TLKIG....FN....AVHG......YYIQISQGQ...AHKAPIHYVRRQTLKNAERYIIPELKEY 9 NLKVG....YN....RIHG......YYIELPRVQ...AEQAPADYIRRQTLKGAERFITPELKAF 10 NLKVG....YN....RIHG......YFIELPRVQ...AEQAPADYIRRQTLKGAERFITPELKAF 11 NLKVG....YN....RIHG......YFIELPRVQ...AEQAPADYIRRQTLKGAERFITPELKAF 12 TLKVG....YN....NVHG......FYIQVSRGQ...SHLVPPHYVRRQTLKNAERYIIEELKQH 13 TRPYY....EK....VPQE......YRPVQTLKD...RQRYTLPEMKERERELYRLEALIKRREE 14 TLKVG....YN....AVHG......YYIQISRGQ...SHLAPINYVRRQTLKNAERYIIPELKEY 15 TRPYY....EK....VPQE......YRPVQTLKD...RQRYTLPEMKERERELYRLEALIKRREE 16 NQVFG....YY....IEVT......KANLDKIPD...DYERKQTLVNSERFITPELKEFETKIMA 17 QSTLI....SA....ARDL......GLDpgkQIK...LDSSAQFGYYFRVTCKEEKVLRNNknFS 18 QSTLI....SA....ARDL......GLDpgkQIK...LDSSAQFGYYFRVTCKEEKVLRNNknFS 19 QSTLI....SA....ARDL......GLDpgkQIK...LDSSAQFGYYFRVTCKEEKVLRNNknFS 20 NQVFG....YY....IEVT......KANLDKIPD...DYERKQTLVNSERFITPELKEFETKIMA 21 ANLKV....GY....NKAF......GYYLSLPRS...KSEQAPDNYIRKQTLVNEERYITPELKE 22 ANLKV....GY....NKAF......GYYLSLPRS...KSEQAPDNYIRKQTLVNEERYITPELKE 23 QSTLI....NA....ARGL......GLDpgkQIK...LDSSAQFGYYFRVTCKEEKVLRNNknFS 24 QSTLI....NA....ARGL......GLDpgkQIK...LDSSAQFGYYFRVTCKEEKVLRNNknFS 25 TPKAG....FD....SDYD......QALADIREN...EQSLLEYLEKQRNRIGCRTIVYWGIGRN 26 TPKAG....FD....SDYD......QALADIREN...EQSLLEYLEKQRNRIGCRTIVYWGIGRN 27 TPKAG....FD....SDYD......QALADIREN...EQSLLEYLEKQRNRIGCRTIVYWGIGRN 28 TPKAG....FD....SDYD......QALADIREN...EQSLLEYLEKQRNRIGCRTIVYWGIGRN 29 TLKVG....YN....AVHG......YYIQISRGQ...SHLAPINYVRRQTLKNAERYIIPELKEY 30 TPKAG....FD....SDYD......QALADIREN...EQSLLEYLDKQRSRLGCKSIVYWGIGRN 31 QSTLI....SA....ARGL......GLDpgkQIK...LDSSAQFGYYFRVTCKEEKVLRNNknFS 32 TPKAG....FD....SDYD......QALADIREN...EQSLLEYLEKQRNRIGCRTIVYWGIGRN 33 TPKAG....FD....SDYD......QALADIREN...EQSLLEYLDKQRSRLGCKSIVYWGIGRN 34 YYFHV....TN....SQLG......NVPAHFFRK...ATLKNSERFGTEELARIEGDMLEAREKS 35 KKLKV....CY....AQAL......GYYIEVASN...LAPQLPKEFIRRQSRLHAERFTTQELQQ 36 LKVEF....NR....VHGF......YIELSKTQA...EQAPADYQRRQTLKNAERFITPELKAFE 37 YYIEV....TK....ANLH......LLEEGrYER...NETLTNAERYITPELKEKEALILEAENN 38 LKVEF....NR....VHGF......YIELSKTQA...EQAPADYQRRQTLKNAERFITPELKAFE 39 TLKVG....YN....RVHG......YYIEISKGQ...ADKAPVHYTRRQTLTNAERYITEELKAF 40 KKLKI....CF....AQAL......GYYIEVSSE...FAPQLPKDFIRRQSRLHAERFTTIELQQ 41 NEIQE....VI....HSIQ......MRLQEFRKI...LKLPSLQYVTVSGQEFMIEIKNSAVSCI 42 NEIQE....VI....HSIQ......MRLQEFRKI...LKLPSLQYVTVSGQEFMIEIKNSAVSCI 43 NEIQE....VI....HSIQ......MRLQEFRKI...LKLPSLQYVTVSGQEFMIEIKNSAVSCI 44 SLKIG....YN....KVMG......YYIEVTKAN...VKYVPEHFRRRQTLSNAERYTTEELQRL 45 YYIEV....TK....ANLH......LLEEGrYER...NETLTNAERYITPELKEKEALILEAENN 46 KKLKI....CF....AQAL......GYYIEVSSE...FAPQLPKDFIRRQSRLHAERFTTIELQQ 47 KKLKV....CY....AQAL......GYYIEVASS...FAPQLPKEFIRRQSRLHAERFTTQELQQ 48 QGALG....GA....AREL......GLDagkSIK...LESNSQIGHYFRVTCKEEKALRNNkkFT 49 SLKIG....YN....KVMG......YYIEVTKPN...LKYVPSYFRRRQTLSNSERFTTEELQRL 50 LMEIL....MT....YRKQ......FKCSNIQYK...DSGKEIYTIEIPISATKNVPSNWVQMAA 51 LMEIL....MT....YRKQ......FKCSNIQYK...DSGKEIYTIEIPISATKNVPSNWVQMAA 52 QSTLI....SA....ARDL......GLDpgkQIK...LDSSAQFGYYFRVTCKE----------- 53 NEIQE....VI....HSIQ......MRLQEFRKI...LKLPSLQYVTVSGQEFMIEIKNSAVSCI 54 SLKIS....HN....NVLG......FFIDITPKN...VNKiLDPKFIHRQTTINSVRYTTYELQN 55 QKYQS....EL....KNEL......YALLEQYKK...QLRCSSLNFKNIGKEVYQVEVPSDV--K 56 GTLKM....KY....NRML......GHFLEVSKG...HLSAVPAHFIRRRSLSNADRFTTEQLSE 57 VIPHE....GA....DEEY......DCACKTVEE...FESSLKKHLKEQRKLLGDASINYVTVGK 58 SLKIK....HN....NVLG......YFIEVTAGN...AGSMTDTdagrarFIHRQTMANAMRFTT 59 VIPHE....GA....DEEY......DCACKTVEE...FESSLKKHLKEQRKLLGDASINYVTVGK 60 RkDEI....QG....VIDE......IRMHLQEIR...KILKNPSAQYVTVSGQEFMIEIKNSAVS 61 -----....--....----......---------...---------------------------- 62 LQvdk....AL....KLDK......AAQFGHVFR...ITKKEEPKIRKKlttqFIVLETRKDGVK 63 RkDEI....QG....VIDE......IRMHLQEIR...KILKNPSAQYVTVSGQEFMIEIKNSAVS 64 RKTNN....RG....LFFE......VTKSNYAQV...PPHFMESQALNSSKRYKTEKLISLEVDI 65 IVPNA....GC....DEEY......DEALNRVKE...ALNELNDYKDSVAKKYSCS-IKFVDSGK 66 -----....--....----......---------...---------------------------- 67 SKMEE....LQ....FKCS......QELNLDgkn...QVKLESVAKLGHHFRITVKDDSVLRKNk 68 QErek....KI....FLEN......HKVHGWCMR...LTRTEAGCIRNNsrYLECSTQKNGVYFT 69 SKMEE....LQ....FKCS......QELNLDgkn...QVKLESVAKLGHHFRITVKDDSVLRKNk 70 KMSIL....MV....RTEM......DFHLQELRD...YLEYPNLEFSIWGNVKFCIEVSKGC-KK 71 KMSIL....MV....RTEM......DFHLQELRD...YLEYPNLEFSIWGNVKFCIEVSKGC-KK 72 AGMDA....EY....DAAM......DSIGEVEKR...LKTYLVEQERHFGCR-ITYFGSDKKRYQ 73 QRESE....SV....RSQL......KEELAEIRK...YLKRPYLNFR--DEVDYLIEVKNSQIKD 74 SSDQF....PE....LAEA......RQAVLVIRE...KLDSSIASFRKKLAIRNLEFLQVSGITH 75 LQvdk....AL....KLDK......AAQFGHVFR...ITKKEEPKIRKKlttqFIVLETRKDGVK 76 QRESE....SV....RSQL......KEELAEIRK...YLKRPYLNFR--DEVDYLIEVKNSQIKD 77 ELGKI....RS....KLDT......LRDEIHSIH...LDSAEDLGFDpdkKLKLENHHLHGWCMR 78 ELGKI....RS....KLDT......LRDEIHSIH...LDSAEDLGFDpdkKLKLENHHLHGWCMR 79 -----....--....----......---------...---------------------------- 80 SSEFD....IR....QSFK......EN-------...--------------------WVVKSNFN 81 -----....--....----......---------...---------------------------- 82 KCSQE....LN....LDgkn.....QVKLESVAK...LGHHFRITVKDDSVLRKNknYRIVDVIK 83 LSvdk....QL....KLEK......-GSLGHVFR...MSKKEEQKVRKKltgsYLIIETRKDGVK 84 -----....--....----......---------...---------------------------- 85 AEFDE....EL....LDLR......QRLDELQHS...IFEEHKRVGSDLHQDtekKLHLEQHHLY 86 AEFDE....EL....LDLR......QRLDELQHS...IFEEHKRVGSDLHQDtekKLHLEQHHLY 87 --DIL....IT....SSDQ......FPELAEARQ...AVLVIREKLDSSIASFRKKLAIRNLEFL 88 -----....--....----......---------...---------------------------- 89 -----....--....----......---------...---------------------------- 90 --DIL....IT....SSDQ......FPELAEARQ...AVLVIREKLDSSIASFRKKLAIRNLEFL 91 KKESN....KD....EIFE......L--------...---------------------------- 92 -----....--....----......---------...---------------------------- 93 KKESN....KD....EIFE......L--------...---------------------------- 94 FECDN....LK....LDKN......SQYGFYFRV...TLKEEKSIRKKdvHILETTKGSGVKFSV 95 VVKAI....ES....EHQR......VMKVYGWTek..QLKCEYHTTYGYVFRVTRKEDQQVRTSk 96 -----....--....----......---------...---------------------------- 97 FLTEV....AQ....KELE......NLDsrIPSC...SVIYIPLIGFLLSIPR------------ 98 FLTEV....AQ....KELE......NLDsrIPSC...SVIYIPLIGFLLSIPR------------ 99 SSEFD....IR....QSFK......EN-------...--------------------WVVKSNFN 100 LTAIA....KQ....EEAR......LGLPpysNV...ACVYIPLVGFVLSVPRDY---------- 101 LTAIA....KQ....EEAR......LGLPpysNV...ACVYIPLVGFVLSVPRDY---------- 102 DIAGM....IS....QLGE......KYSLP-LRT...SFSSARGFFIQMTTDCIalpsDQLPSEF 103 LTEVA....RK....ELEN......LDsrIPSCS...VIYIPLIGFLLSIPR------------- 104 DIAGM....IS....QLGE......KYSLP-LRT...SLSSVRGFFIQMTTDCIalpsDQLPSEF 105 LTEVA....RK....ELEN......LDsrIPSCS...VIYIPLIGFLLSIPR------------- 106 LTEVA....RK....ELEN......LDsrIPSCS...VIYIPLIGFLLSIPR------------- 107 EFFRE....VE....DLTA......KNKIN-LDH...NYDSARGFYLRIKRQEFTDdvatLPDVF 108 EFFRE....VE....DLTA......KNKIN-LDH...NYDSARGFYLRIKRQEFTDdvatLPDVF 109 IRDTY....EN....MPMV......LTAIAKQEE...ARLGLPpysNVACVYIPLVGFVLSVPRD 110 QDttS....IK....AEYF......NKEGYAFSI...SSKKLTKLEHYMMNTSISNN-------- 111 YEEII....RN....VEET......GAREIAEYF...HGnsSVRLSFSQSRGFHYTFVTRQAESv 112 YVNVG....KD....MYLI......EVPESLGGS...VPRNYELQSTKKGFYRYWTPELKELILE 113 -----....--....----......---------...---------------------------- 114 YFIEL....PT....KQAE......QAPGDYIRR...QTLKGAERFITPELKAFEDKALSAKSRA 115 -----....--....----......---------...---------------------------- 116 GILLD....VA....RETQ......IFLLNTmpq...14lekLVNAVYIPQLGYLVTISVLMEPL 117 LLNTmpq..14lek.LVNA......VYIPQLGYL...VTISVLMEPLldgIPNLqWEEIFRSSEN 118 -----....--....----......---------...---------------------------- 119 -----....--....----......---------...----------------------------