; SAM: prettyalign v3.2 (July 31, 2000) compiled 08/11/00_16:27:51 ; (c) 1992-2000 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequences correspond to the following labels: ; 1 gi|9864530|gb|AAG00261.1|_10:389 ; 2 gi|4151103|emb|CAA07342.1|_21:366 ; 3 gi|7522263|pir||T39832_21:366 ; 4 gi|4775576|emb|CAB42554.1|_29:348 ; 5 gi|3914056|sp|O24617|MSH2_ARATH_27:346 ; 6 gi|4139230|gb|AAD04176.1|_27:346 ; 7 gi|3914053|sp|O13396|MSH2_NEUCR_14:341 ; 8 gi|1079288|pir||S53609_19:353 ; 9 gi|1000879|gb|AAB59570.1|_19:354 ; 10 gi|1000883|gb|AAB59571.1|_19:354 ; 11 gi|4557761|ref|NP_000242.1|_19:354 ; 12 gi|7448104|pir||I64827_19:354 ; 13 gi|1000875|gb|AAB59568.1|_19:354 ; 14 gi|2135744|pir||I37550_19:354 ; 15 gi|1000873|gb|AAB59567.1|_19:338 ; 16 gi|1000877|gb|AAB59569.1|_19:354 ; 17 gi|726086|gb|AAA75027.1|_19:354 ; 18 gi|6678938|ref|NP_032654.1|_19:354 ; 19 gi|1709122|sp|P54275|MSH2_RAT_19:354 ; 20 gi|7298155|gb|AAF53392.1|_24:355 ; 21 gi|7287834|gb|AAF44872.1|AE003406_77_24:355 ; 22 gi|1174416|sp|P43248|MSH2_DROME_9:351 ; 23 gi|3886083|gb|AAC78226.1|_17:324 ; 24 gi|3831701|gb|AAC70065.1|_188:335 ; 25 gi|3914066|sp|Q19272|MSH5_CAEEL_188:335 ; 26 gi|8515837|gb|AAF76200.1|_188:335 ; 27 gi|730066|sp|P40965|MSH4_YEAST_101:317 ; 28 gi|6321109|ref|NP_011187.1|_101:317 ; 29 gi|4505251|ref|NP_002431.1|_150:361 ; 30 gi|4336728|gb|AAD17920.1|_150:361 ; 31 gi|6224917|gb|AAF06013.1|AF193018_1_255:604 ; 32 gi|9294039|dbj|BAB01996.1|_255:604 ; 33 gi|4775580|emb|CAB42556.1|_47:392 ; 34 gi|4775578|emb|CAB42555.1|_354:699 ; 35 gi|1588283|prf||2208298A_299:667 ; 36 gi|6320302|ref|NP_010382.1|_299:667 ; 37 gi|7492209|pir||T41262_362:716 ; 38 gi|7331984|gb|AAF60672.1|_840:1223 ; 39 gi|1709123|sp|P52701|MSH6_HUMAN_395:784 ; 40 gi|7512473|pir||JC5840_395:784 ; 41 gi|4504191|ref|NP_000170.1|_395:784 ; 42 gi|1082386|pir||A56742_327:716 ; 43 gi|7512474|pir||JC5839_395:784 ; 44 gi|6754744|ref|NP_034960.1|_394:781 ; 45 gi|2506881|sp|P54276|MSH6_MOUSE_394:781 ; 46 gi|7294307|gb|AAF49656.1|_250:624 ; 47 gi|2104549|gb|AAB57798.1|_374:760 ; 48 gi|6226648|sp|O04716|MSH6_ARATH_367:747 ; 49 gi|3024198|sp|P70755|MUTS_AQUPY_5:307 ; 50 gi|3914079|sp|O66652|MUTS_AQUAE_4:310 ; 51 gi|7387924|sp|Q9Z6W5|MUTS_CHLPN_5:321 ; 52 gi|7189834|gb|AAF38705.1|_5:321 ; 53 gi|7387913|sp|O84797|MUTS_CHLTR_4:315 ; 54 gi|7190210|gb|AAF39048.1|_4:315 ; 55 gi|6647605|sp|Q9ZDM9|MUTS_RICPR_13:338 ; 56 gi|8473172|sp|P56883|MUTS_RHIME_21:348 ; 57 gi|7404405|sp|P73769|MUTS_SYNY3_22:351 ; 58 gi|7448108|pir||S74860_56:385 ; 59 gi|2072992|gb|AAC46142.1|_1:130 ; 60 gi|7404403|sp|P49849|MUTS_BACSU_3:300 ; 61 gi|1002520|gb|AAB19235.1|_1:294 ; 62 gi|7328284|emb|CAB82466.1|_3:301 ; 63 gi|123080|sp|P10564|HEXA_STRPN_4:303 ; 64 gi|127555|sp|P27345|MUTS_AZOVI_3:315 ; 65 gi|7229490|gb|AAF42850.1|_4:315 ; 66 gi|7108493|gb|AAF36440.1|AF126491_1_4:315 ; 67 gi|9654962|gb|AAF93703.1|_7:322 ; 68 gi|79102|pir||A28668_7:319 ; 69 gi|417330|sp|P10339|MUTS_SALTY_7:319 ; 70 gi|127556|sp|P23909|MUTS_ECOLI_6:317 ; 71 gi|4887554|emb|CAB43497.1|_6:317 ; 72 gi|1592569|gb|AAB97931.1|_6:315 ; 73 gi|1171081|sp|P44834|MUTS_HAEIN_3:317 ; 74 gi|9106782|gb|AAF84525.1|AE003995_7_39:355 ; 75 gi|7227419|gb|AAF42468.1|_4:314 ; 76 gi|7379009|emb|CAB83555.1|_4:314 ; 77 gi|6093453|sp|O83348|MUTS_TREPA_5:319 ; 78 gi|3914075|sp|O51737|MUTS_BORBU_4:312 ; 79 gi|6226653|sp|P74926|MUTS_THEMA_3:299 ; 80 gi|1619909|gb|AAB16999.1|_3:299 ; 81 gi|7522430|pir||T38256_2:232 ; 82 gi|6166561|sp|O13921|MSH1_SCHPO_50:393 ; 83 gi|7490460|pir||T37626_49:191 ; 84 gi|172000|gb|AAA34801.1|_69:414 ; 85 gi|6321912|ref|NP_011988.1|_69:414 ; 86 gi|7387928|sp|Q9ZIX6|MUTS_THECA_8:305 ; 87 gi|2145507|pir||S62790_18:307 ; 88 gi|2497996|sp|Q56239|MUTS_THETH_10:308 ; 89 gi|1871501|dbj|BAA09880.1|_10:308 ; 90 gi|2497995|sp|Q56215|MUTS_THEAQ_2:300 ; 91 T0116-1-300 ; 92 gi|1083296|pir||JC4019_189:578 ; 93 gi|6981224|ref|NP_034959.1|_143:373 ; 94 gi|387849|gb|AAB60711.1|_175:543 ; 95 gi|110917|pir||A32495_175:543 ; 96 gi|400971|sp|P13705|MSH3_MOUSE_175:543 ; 97 gi|4505249|ref|NP_002430.1|_211:576 ; 98 gi|118951|sp|P20585|MSH3_HUMAN_220:585 ; 99 gi|7547005|gb|AAF63754.1|AF242852_1_64:256 ; 100 gi|3914062|sp|O65607|MSH3_ARATH_94:456 ; 101 gi|3319876|emb|CAA07684.1|_94:473 ; 102 gi|7269404|emb|CAB81364.1|_94:456 ; 103 gi|1076927|pir||S22569_5:363 ; 104 gi|135075|sp|P26359|SWI4_SCHPO_95:455 ; 105 gi|6319935|ref|NP_010016.1|_152:495 ; 106 gi|448278|prf||1916402A_152:494 10 20 30 40 50 | | | | | 1 ----------------........LQAFTAVGGDDKACVRLFSRGgstpGCYVLGS.WAGFIARE 2 ----------------........---FYEKMPKDTNTVRVFDRG....EFYVAIG.EDASFVAQ 3 ----------------........---FYEKMPKDTNTVRVFDRG....EFYVAIG.EDASFVAQ 4 ----------------........---FFKKLPQDPRAVRLFDRR....DYYTAHG.ENATFIAR 5 ----------------........---FYKTLPNDTRAVRFFDRK....DYYTAHG.ENSVFIAK 6 ----------------........---FYKTLPNDTRAVRFFDRK....DYYTAHG.ENSVFIAK 7 --------------GF........IRFYKSLPQLGEEAIRIFDRG....DWYTAHG.DDATFIAR 8 ---------------F........LHFYQSMPEKPDTTVRVFDRN....DYYTVHG.GDALFAAK 9 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 10 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 11 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 12 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 13 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 14 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 15 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 16 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 17 ---------------F........VRFFEGMPEKPSTTVRLFDRG....DFYTAHG.EDALLAAR 18 ---------------F........VRFFEGMPEKPSTTVRLFDRG....DFYTAHG.EDALLAAR 19 ---------------F........VRFFEGMPEKPSTTVGLFDRG....DFYTAHG.EDALLAAR 20 ---------------F........IKFHAKLGEKPATTVRFFDHT....DRYTVHGsDDCELVAK 21 ---------------F........IKFHAKLGEKPATTVRFFDHT....DRYTVHGsDDCELVAK 22 ----YPEYGHKCASNF........IKFHAKLGEKPATTVRFFDHT....DRYTVHGsDDCELVAK 23 ----------------........------LKSKSPNTIAIFSRG....EYFSVYG.DDATFVAT 24 ----------------........---------------------....-------.-------- 25 ----------------........---------------------....-------.-------- 26 ----------------........---------------------....-------.-------- 27 ----------------........---------------------....-------.-------- 28 ----------------........---------------------....-------.-------- 29 ----------------........---------------------....-------.-------- 30 ----------------........---------------------....-------.-------- 31 KTLHIPPDVFKKMSAS........QKQYWSVKSEYMDIVLFFKVG....KFYELYE.LDAELGHK 32 KTLHIPPDVFKKMSAS........QKQYWSVKSEYMDIVLFFKVG....KFYELYE.LDAELGHK 33 -TLFIPPDALRKMSTS........QKQYWNIKCKYMDVVLFFKVG....KFYELYE.LDAEIGQK 34 -TLFIPPDALRKMSTS........QKQYWNIKCKYMDVVLFFKVG....KFYELYE.LDAEIGQK 35 RTLYIPSSAWNKFTPF........EKQYWEIKSKMWDCIVFFKKG....KEFELYE.KDALLANA 36 RTLYIPSSAWNKFTPF........EKQYWEIKSKMWDCIVFFKKG....KFFELYE.KDALLANA 37 RTLYIPPSAWATFKPF........EKQFWKIKKDLMDTVVFFQKG....KFYELYE.NDAAIGHQ 38 KTLWVPPDFHQKQTPG........HRQWWTMKSQHFDTILLFKVG....KFYETYH.MDAVEVVR 39 -TLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVS 40 -TLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVS 41 -TLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVS 42 -TLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVS 43 -TLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVS 44 -TLYVPEEFLNSCTPG........MRKWWQLKSQNFDLVIFYKVG....KFYELYH.MDAVIGVS 45 -TLYVPEEFLNSCTPG........MRKWWQLKSQNFDLVIFYKVG....KFYELYH.MDAVIGVS 46 -TLHVPEKFLNGLSPG........VRQWWVLKSDNYDCVLFFKVG....KFYELYH.MDADVGVN 47 --LYLPPDFVKKLTGGqvrrahgnLRQWWEFKAKHMDKVVFFKMG....KFYELFE.MDAHVGAK 48 RTLYLPPDFVKKLTGG........QRQWWEFKAKHMDKVVFFKMG....KFYELFE.MDAHVGAK 49 ---------EKELTPM........LAQYHQFKSMYPDCLLLFRLG....DFYELFY.EDAVVGSK 50 --------SEKELTPM........LSQYHYFKNQYPDCLLLFRLG....DFYELFY.EDAYIGSK 51 -----------KPTPM........MEQWHQCKEKAGDSVLLFRMG....DFYEAFY.DDAVLLSQ 52 -----------KPTPM........MEQWHQCKEKAGDSVLLFRMG....DFYEAFY.DDAVLLSQ 53 -----------KLTPM........MQQWHQCKEQAGDCLLLFRLG....EFYEAFF.DDALILAQ 54 -----------KLTPM........MQQWHQCKEQAGDCLLLFRLG....EFYEAFF.DDALVLAQ 55 -----QKYNYNVATKM........MQQYLDIKFAHLDCLLLFRMG....DFYELFY.EDAILASN 56 ----ASEESRSTATPM........MEQFIEIKANNPDSLLFYRMG....DFYELFF.QDAVEASR 57 ---------RQKLTPM........FQHYTEVKEQYQGALLLYRVG....DFFECFF.QDAVIIAR 58 ---------RQKLTPM........FQHYTEVKEQYQGALLLYRVG....DFFECFF.QDAVIIAR 59 ----------------........---------------------....----CFF.QDAIVVAR 60 -----------GYTPM........IQQYLKIKAEHQDAFLFFRLG....DFYEMFF.EDAKKASQ 61 ---------------M........IQQYLKIKAEHQDAFLFFRLG....DFYEMFF.EDAKKASQ 62 -----------NVTPM........MQQYLKIKSEYQDCLLFFRLG....DFYEMFY.EDAKEASR 63 ----------EKLSPG........MQQYVDIKKQYPDAFLLFRMG....DFYELFY.EDAVNAAQ 64 --------SLSQHTPM........MQQYWKLKREHPDQLMFYRMG....DFYELFY.EDAKKAAK 65 ---------LSQHTPM........MQQYFKLKHQHPDQLMFYRMG....DFYELFY.EDAKKAAK 66 ---------LSQHTPM........MQQYFKLKHQHPDQLMFYRMG....DFYELFY.EDAKKAAK 67 ----SPSESLSHHTPM........MQQYLRLKAENPDILLFYRMG....DFYELFY.DDAKRASE 68 -------KDFSNHTPM........MQQYLKLKAQHPEILLFYRMG....DFYELFY.DDAKRASQ 69 -------KDFSNHTPM........MQQYLKLKAQHPEILLFYRMG....DFYELFY.DDAKRASQ 70 --------NFDAHTPM........MQQYLRLKAQHPEILLFYRMG....DFYELFY.DDAKRASQ 71 --------NFDAHTPM........MQQYLKLKAQHPEILLFYRMG....DFYELFY.DDAKRASQ 72 --------NFDAHTPM........MQQYLKLKAQHPEILLFYRMG....DFYELFY.DDAKRASQ 73 -----SEENFQQHTPM........MQQYLKLKAENPDILLFYRMG....DFYELFY.DDAKKAAA 74 --KPEGGKGMAEHTPL........MKQYFAAKAEYPDLLLFFRMG....DFYELFH.QDARKAAR 75 ----------SAVSPM........MQQYLGIKAQHTDKLVFYRMG....DFYEMFF.DDAVEAAK 76 ----------SAVSPM........MQQYLGIKAQHTDKLVFYRMG....DFYEMFF.DDAVEAAK 77 ----------ASDTPL........MRQYHAIRAQHPDAVLFFRLG....DFYEMFD.SDALHVST 78 -----------NVTPM........IRQYLDIKKKYKDAVLFFRVG....SFYEMFF.DDAIEVSK 79 ------------VTPL........MEQYLRIKEQYKDSILLFRLG....DFYEAFF.EDAKIVSK 80 ------------VTPL........MEQYLRIKEQYKDSILLFRLG....DFYEAFF.EDAKIVSK 81 ----------------........---------------------....-------.-------- 82 --DFIRPKEKVTLPPL........LKEVSFQQKKFADCVLLTKVG....NFYEMYF.EQAEKIGP 83 -LDFIRPKEKVTLPPL........LKEVSFQQKKFADCVLLTKVG....NFYEMYF.EQAEKIGP 84 --LSSTEPSKASLPPS........LQYVRDLMDLYKDHVVLTQMG....SFYELYF.EQAIRYAP 85 --LSSTEPSKASLPPS........LQYVRDLMDLYKDHVVLTQMG....SFYELYF.EQAIRYAP 86 --VMLKGEGPGPLPPL........LQQYVELRDRYPDYLLLFQVG....DFYECFG.EDAERLAR 87 ----------PPLPPL........LQQYVELRDRYPDYLLLFQVG....DFYECFG.EDAERLAR 88 -EGMLKGEGPGPLPPL........LQQYVELRDRYPDYLLLFQVG....DFYECFG.EDAERLAR 89 -EGMLKGEGPGPLPPL........LQQYVELRDRYPDYLLLFQVG....DFYECFG.EDAERLAR 90 -EGMLKGEGPGPLPPL........LQQYVELRDQYPDYLLLFQVG....DFYECFG.EDAERLAR 91 MEGMLKGEGPGPLPPL........LQQYVELRDQYPDYLLLFQVG....DFYECFG.EDAERLAR 92 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAAR 93 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAAR 94 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAAR 95 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAAR 96 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAAR 97 ---SANKRSKSIYTPL........ELQYIEMKQQHKDAVLCVECG....YKYRFFG.EDAEIAAR 98 ---SANKRSKSIYTPL........ELQYIEMKQQHKDAVLCVECG....YKYRFFG.EDAEIAAR 99 ----------IKYTPL........EQQVVELKRKHPDVILMVEVG....YRYRFFG.EDAEIAAR 100 --YVPETSSSRKYTPL........EQQVVELKSKYPDVVLMVEVG....YRYRFFG.EDAEIAAR 101 --YVPETSSSRKYTPL........EQQVVELKSKYPDVVLMVEVG....YRYRFFG.EDAEIAAR 102 --YVPETSSSRKYTPL........EQQVVELKSKYPDVVLMVEVG....YRYRFFG.EDAEIAAR 103 ------TKQKSVFTPL........EQQYLELKKNYQETILAIEVG....YKFRFFG.KDAKIASE 104 ----KPTKQKSVFTPL........EQQYLELKKNYQETILAIEVG....YKFRFFG.KDAKIASE 105 ---KARKSPTAKLTPL........DKQVKDLKMHHRDKVLVIRVG....YKYKCFA.EDAVTVSR 106 ---KARKSPTAKLTPL........DKQVKDLKMHHRDKVLVIRVG....YKY-CFA.EDAVTVSR 60 70 80 90 1 | | | | 1 YIRS......TAVL-........-KN.WGGVDVVVVNDSIAKEVIRDc.LL..RRGASVEYYERP 2 NAYH......TTSVLk.......HHN.VSNTSYCNLSPSLFIKFAEDv.LS..NLAKRVEIW--- 3 NAYH......TTSVLk.......HHN.VSNTSYCNLSPSLFIKFAEDv.LS..NLAKRVEIW--- 4 TYYH......TMSALrql.....GSS.SDGILSASVSKAMFETIARNilLE..RTDCTLELYEGS 5 TYYH......TTTALrql.....GSG.SNALSSVSISRNMFETIARD..LLleRNDHTVELYEGS 6 TYYH......TTTALrql.....GSG.SNALSSVSISRNMFETIARD..LLleRNDHTVELYEGS 7 TVYK......TTSVIrqlg....RSD.HTGLPSVTMTVTVFRQFLREa.LF..KLGKRIEIW--- 8 EVFK......TNGVIkyl.....GSG.NKKLESVVLSKMNFESVVKDl.LL..VRQYRVEVYKNK 9 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 10 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 11 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 12 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 13 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 14 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 15 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 16 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 17 EVFK......TQGVIkymg....PAG.SKTLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNK 18 EVFK......TQGVIkymg....PAG.SKTLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNK 19 EVFK......TQGVIkymg....PAG.AKTLQTVVLSKMNFESFVKDl.LL..VRHYRVEVYKNK 20 IVYK......STAFIgallp...DDK.KETLQFVSMSKGNFELAVREl.LL..VRNYRVEVY--- 21 IVYK......STAFIgallp...DDK.KETLQFVSMSKGNFELAVREl.LL..VRNYRVEVY--- 22 IVYK......STAFIgallp...DDK.KETLQFVSMSKGNFELAVREl.LL..VRNYRVEVY--- 23 NIFKsdvcvkTFTLS........TDN.SQQMKYISVNRGQYEKVVREt.IV..LLRCSVELY--- 24 ----......-----........---.--------------------..--..------------ 25 ----......-----........---.--------------------..--..------------ 26 ----......-----........---.--------------------..--..------------ 27 ----......-----........---.--------------------..--..------------ 28 ----......-----........---.--------------------..--..------------ 29 ----......-----........---.--------------------..--..------------ 30 ----......-----........---.--------------------..--..------------ 31 ELDW......KMTM-........-SG.VGKCRQVGISESGIDEAVQK..LL..ARGYKVGRIEQL 32 ELDW......KMTM-........-SG.VGKCRQVGISESGIDEAVQK..LL..ARGYKVGRIEQL 33 ELDW......KMTV-........-SG.VGKCRQVGISESGIDDAVDK..LI..ARGYKVGRIEQM 34 ELDW......KMTV-........-SG.VGKCRQVGISESGIDDAVDK..LI..ARGYKVGRIEQM 35 LFDL......KIAG-........-GG.RANMQLAGIPEMSFEYWAAQ..FI..QMGYKVAKVDQR 36 LFDL......KIAG-........-GG.RANMQLAGIPEMSFEYWAAQ..FI..QMGYKVAKVDQR 37 VFSL......KLTDR........---.-VNMKMVGIPEASFDYWASQ..FI..AKGYRIARVDQL 38 ALNI......AFMR-........---.-GSYAHAGFPEHAASKFADQ..LM..NHGYKVARIEQT 39 ELGL......VFMK-........---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQT 40 ELGL......VFMK-........---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQT 41 ELGL......VFMK-........---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQT 42 ELGL......VFMK-........---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQT 43 ELGL......VFMK-........---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQT 44 ELGL......IFMK-........---.-GNWAHSGFPEIAFGRFSDS..LV..QKGYKVARVEQT 45 ELGL......IFMK-........---.-GNWAHSGFPEIAFGRFSDS..LV..QKGYKVARVEQT 46 ELGF......TYMR-........---.-GEFAHSGFPEISFDKMSTI..LV..DRGFKVARVEQT 47 ELDI......QYMK-........---.-GEQPHCGFPEKNFSVNIEK..LV..RKGYRVLVVEQT 48 ELDI......QYMK-........---.-GEQPHCGFPEKNFSVNIEK..LV..RKGYRVLVVEQT 49 ELGL......VLTSRpa......GKG.RERIPMCGVPYHSANNYIAK..LV..NKGYKVAICEQV 50 ELGL......VLTSRpa......GKG.KERIPMCGVPYHSANSYIAK..LV..NKGYKVAICEQV 51 HLEL......TLTQR........---.-QGIPMSGIPVSTVDTYVDR..LI..GKGFKVAVAEQF 52 HLEL......TLTQR........---.-QGIPMSGIPVSTVDTYVDR..LI..GKGFKVAVAEQF 53 NLDI......TLTQR........---.-QNVPMSGIPATCLDGYVDR..LV..SRGFKVAIAEQA 54 NLDI......TLTQR........---.-QNIPMSGIPAAYLDGYVDR..LV..SRGFKIAIAEQA 55 ILGI......ALTKR........GKNcEEEIPMCGVPYHALEHYLTK..LI..EENYKVAICDQL 56 ALGI......TLTKR........GQHmGQEIPMCGVPVHAADDYLQK..LI..ASGYRVAVCEQV 57 ELEL......ILTSKeg......GKE.IGRVAMTGVPHHALDRYARQ..LV..EKGYAVAICDQV 58 ELEL......ILTSKeg......GKE.IGRVAMTGVPHHALDRYARQ..LV..EKGYAVAICDQV 59 ELEL......VLTSKea......GKE.VGRVPMAGIPYHALDRYASQ..LV..EKGYAIAICDQV 60 ELEI......TLTSR........DGGaAEKIPMCGVPYHSASAYIEQ..LI..KKGYKVAICEQT 61 ELEI......TLTSR........DGGaAEKIPMCGVPYHSASAYIEQ..LI..KKGYKVAICEQT 62 VLEI......TLTKR........DAKkENPIPMCGVPYHSADSYIDT..LV..NNGYKVAICEQM 63 ILEI......SLTSR........NKNaDNPIPMAGVPYHSAQQYIDV..LI..EQGYKVAIAEQM 64 LLDI......TLTAR........GQSaGKSIPMAGIPFHSVEGYLAK..LV..KLGESVAICEQI 65 LLDI......TLTAR........GQSgGKAIPMAGIPFHSAEGYLAK..LV..KLGESVAICEQI 66 LLDI......TLTAR........GQSgGKAIPMAGIPFHSAEGYLAK..LV..KLGESVAICEQI 67 LLDI......SLTKR........GASaGEPIPMAGVPFHAVEGYLAK..LV..QMGESVAICEQI 68 LLDI......SLTKR........GASaGEPIPMAGIPHHAVENYLAK..LV..NQGESVAICEQI 69 LLDI......SLTKR........GASaGEPIPMAGIPHHAVENYLAK..LV..NQGESVAICEQI 70 LLDI......SLTKR........GASaGEPIPMAGIPYHAVENYLAK..LV..NQGESVAICEQI 71 LLDI......SLTKR........GASaGEPIPMAGIPYHAVENYLAK..LV..NQGESVAICEQI 72 LLDI......SLTKR........SASaGEPIPMAGIPYHAVENYLAK..LV..NQGESVAICEQI 73 LLDI......SLTKR........GQSaGQPIPMAGMPYHAVEGYLAK..LV..QLGESVAICEQI 74 LLDI......TLTQR........GSSgGAPIPMAGVPVHAYEGYLAR..LI..ALGESVAICEQI 75 LLDI......TLTTR........GQVdGEPVKMAGVPFHAAEQYLAR..LV..KLGKSVAICEQV 76 LLDI......TLTTR........GQVdGEPVKMAGVPFHAAEQYLAR..LV..KLGKSVAICEQV 77 LLGL......TLTKR........---.-NGTPMCGVPVHTARTHIAR..LL..KHGKKVALCEQV 78 LLNL......TLTKR........---.-ENVPMCGVPYHTSKEYIRK..LI..LFDKKVAICEQA 79 VLNI......VLTRR........---.-QDAPMAGIPYHALNTYLKK..LV..EAGYKVAICDQM 80 VLNI......VLTRR........---.-QDAPMAGIPYHALNTYLKK..LV..EAGYKVAICDQM 81 ----......-----........---.--------------------..--..------------ 82 LLNL......RVSKK........KTS.KSDVSMAGFPFFKLDRYLKI..LVe.DLKKCVALSEEV 83 LLNL......RVSKK........KTS.KSDVSMAGFPFFKLDRYLKI..LVe.DLKKCVALSEEV 84 ELNI......SLTNR........AYS.HGKVPFAGFPVHQLSRHLKM..LVn.NCGYSVTIAEQF 85 ELNI......SLTNR........AYS.HGKVPFAGFPVHQLSRHLKM..LVn.NCGYSVTIAEQF 86 ALGL......VLTHK........TSK.DFTTPMAGIPIRAFDAYAER..LL..RMGFGLAVADQV 87 ALGL......VLTHK........TSK.DFTTPMAGIPIRAFDAYAER..LL..KMGFRLAVADQV 88 ALGL......VLTHK........TSK.DFTTPMAGIPIRAFDAYAER..LL..KMGFRLAVADQV 89 ALGL......VLTHK........TSK.DFTTPMAGIPIRAFDAYAER..LL..KMGFRLAVADQV 90 ALGL......VLTHK........TSK.DFTTPMAGIPLRAFEAYAER..LL..KMGFRLAVADQV 91 ALGL......VLTHK........TSK.DFTTPMAGIPLRAFEAYAER..LL..KMGFRLAVADQV 92 ELNI......YCHL-........---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQT 93 ELNI......YCHL-........---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQT 94 ELNI......YCHL-........---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQT 95 ELNI......YCHL-........---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQT 96 ELNI......YCHL-........---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQT 97 ELNI......YCHL-........---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQT 98 ELNI......YCHL-........---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQT 99 VLGI......YAHM-........---.DHSFMTASVPTFRLNVHVRG..LV..NAGYKVGVVKQT 100 VLGI......YAHM-........---.DHNFMTA-------------..--..--RYKIGVVKQT 101 VLGI......YAHM-........---.DHNFMTASVPTFRLNFHVRR..LV..NAGYKIGVVKQT 102 VLGI......YAHM-........---.DHNFMTA-------------..--..--GYKIGVVKQT 103 VLGI......SCYF-........---.EHNFLNASVPSYRIDYHLER..LI..NFGLKVAVVRQT 104 VLGI......SCYF-........---.EHNFLNASVPSYRIDYHLER..LI..NFGLKVAVVRQT 105 ILHI......KLVPGklt10npqDCN.HRQFAYCSFPDVRLNVHLER..LV..HHNLKVAVVEQA 106 ILHI......KLVPGklt10npqDCN.HRQFAYCSFPDVRLNVHLER..LV..HHNLKVAVVEQA 00 110 120 130 | | | | 1 PGG...G---........---TYACVQRGSPGNITDf.EATLF........SF.EEAEIQLMAtg 2 ---...GANS........AKTGFELLKQASPGNMQMl.EDLLVsen13sdsSV.SSVLLAVTTrv 3 ---...GANS........AKTGFELLKQASPGNMQMl.EDLLVsen13sdsSV.SSVLLAVTTrv 4 GS-...----........---NWRLTKSGTPGNIGSf.EDILFanndm...ED.SPVIVALFPac 5 GS-...----........---NWRLVKTGSPGNIGSf.EDVLFannem...QD.TPVVVSIFPsf 6 GS-...----........---NWRLVKTGSPGNIGSf.EDVLFannem...QD.TPVVVSIFPsf 7 ---...ASPS........GRMNWKVVKQASPGNLQDv.EDELGgqf.....EG.APVILAVKIsa 8 SGG...KYSK........E-NDWQLAFKASPGNLTQf.EEILF........GN.NDMSTAVGVvg 9 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 10 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 11 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 12 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 13 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 14 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 15 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 16 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 17 AGN...KASK........E-NEWYLAFKASPGNLSQf.EDILF........GN.NDMSASVGVmg 18 AGN...KASK........E-NEWYLAFKASPGNLSQf.EDILF........GN.NDMSASVGVmg 19 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMATSIGImg 20 ---...--VK........NSSDWEIEYRGSPGNLLQf.EDILF........SN.KEVLVGNSIis 21 ---...--VK........NSSDWEIEYRGSPGNLLQf.EDILF........SN.KEVLVGNSIis 22 ---...--VK........NSSDWEIEYRGSPGNLLQf.EDILF........SN.KEVLVGNSIis 23 ---...--SS........EQGEWKMTKRGSPGNTVDfeQEIGV........SD.QAPILAIYIhp 24 ---...----........------------------..-----........--.---------.. 25 ---...----........------------------..-----........--.---------.. 26 ---...----........------------------..-----........--.---------.. 27 ---...----........------------------..-----........SI.DCVLCCIYEvp 28 ---...----........------------------..-----........SI.DCVLCCIYEvp 29 ---...----........------------------..---SA........HS.PSVIVAVVEgr 30 ---...----........------------------..---SA........HS.PSVIVAVVEgr 31 ETS...DQAKargan...TIIPRKLVQVLTPSTASE..GNIGP........DA.V-HLLAIKEik 32 ETS...DQAKargan...TIIPRKLVQVLTPSTASE..GNIGP........DA.V-HLLAIKEik 33 ESA...NQAKargvh...SVIERKLVHVSTPSTAVDn.---IG........TD.AVHLLALKEvt 34 ESA...NQAKargvh...SVIERKLVHVSTPSTAVDn.---IG........TD.AVHLLALKEvt 35 ESM...LAKEmregsk..GIVKRELQCILTSGTLTD..GDMLH........SDlATFCLAIREep 36 ESM...LAKEmregsk..GIVKRELQCILTSGTLTD..GDMLH........SDlATFCLAIREep 37 ETA...LGKEikd11keeKVVQRGLTQVLTSGTLVD..EAMLT........SDlSTYCMAIKEsl 38 ETP...QMLEern10tkeKVVRREVCRVTSNGTRTY..GVLDGvdl11tldPT.AKHLLAIKEfh 39 ETP...EMMEarc13kydRVVRREICRIITKGTQTY..SVLEGdpse....NY.SKYLLSLKEke 40 ETP...EMMEarc13kydRVVRREICRIITKGTQTY..SVLEGdpse....NY.SKYLLSLKEke 41 ETP...EMMEarc13kydRVVRREICRIITKGTQTY..SVLEGdpse....NY.SKYLLSLKEke 42 ETP...EMMEarc13kydRVVRREICRIITKGTQTY..SVLEGdpse....NY.SKYLLSLKEke 43 ETP...EMMEarc13kydRVVRREICRIITKGTQTY..SVLEGdpse....NY.SKYLLSLKEke 44 ETP...EMMEarc13kfdRVVRREICRIITKGTQTY..SVLDGdpse....NY.SRYLLSLKEke 45 ETP...EMMEarc13kfdRVVRREICRIITKGTQTY..SVLDGdpse....NY.SRYLLSLKEke 46 ETP...DMMTerc12kfdKVVAREICQITNRGTQVF..GSQCKigpn....HQ.PNYMLAIVEkd 47 ETP...DQLEqrr10skdKVVKREVCAVVTKGTLTD..GEMLLtn......PD.ASYLMALTEgg 48 ETP...DQLEqrr10skdKVVKREVCAVVTKGTLTD..GEMLLtn......PD.ASYLMALTEgg 49 EDP...SKAK........GIVKRDVIRVITPGTFFE..-----........RE.TGGLCSLYRk. 50 EDP...SKAK........GIVKREVVRVITPGTFFE..-----........RD.TGGLASLYKk. 51 GEP...AKEKeskki...GPMARDIQRFVTPGTLLS..STLLQe.......KF.NNYIVAINRi. 52 GEP...AKEKeskki...GPMARDIQRFVTPGTLLS..STLLQe.......KF.NNYIVAINRi. 53 DNT...EGSK........GLVPRTINRLITPGALLS..SSLLPe.......KA.NNYVLAINQv. 54 DNS...EGGK........GLVPRTINRLITPGALLS..SSLLPe.......KA.NNYIIAISQv. 55 ETP...EEAKkrdgyk..AVVTRDVTRIITPGTIIE..ENLISv.......TE.PNYLTSLVIpk 56 EDP...AEAKkrgsk...SVVRRDVVRLVTPGTITE..DKLLSp.......SE.SNYLMALARir 57 EDA...AEAQaek.....RMVERQVTKLLTPGTLTD..DSMLPa.......KR.NNFLAAIAMv. 58 EDA...AEAQaek.....RMVERQVTKLLTPGTLTD..DSMLPa.......KR.NNFLAAIAMv. 59 ETA...AQAQg.......PLVRREITRIITPGTILE..EGMLQa.......RR.NNFLAAVVIa. 60 EDP...KAAK........GVVKREVVQLITPGTVMDg.KGIHE........SE.NNFIASVSAc. 61 EDP...KAAK........GVVKREVVQLITPGTVMDg.KGIHE........SE.NNFIASVSAc. 62 EDP...KQTK........GMVRREVVRIVTPGTVMEq.GGVDD........KQ.NNYILSFVMn. 63 EDP...KQAV........GVVKREVVQVITPGTVVD..SSKPD........SQ.NNFLVSIDRe. 64 GDP...ATTK........GPVERQVVRIITPGTVSD..EALLDe.......RR.DNLLAAVVGd. 65 GDP...ATSK........GPVERQVVRIITPGTVSD..EALLDe.......RR.DNLLAAILGd. 66 GDP...ATSK........GPVERQVVRIITPGTVSD..EALLDe.......RR.DNLLAAILGd. 67 GDP...ATSK........GPVERKVVRIVTPGTVTD..EALLSe.......RV.DNLIAAIYHh. 68 GDP...ATSK........GPVERKVVRIVTPGTISD..EALLQe.......RQ.DNLLAAIWQd. 69 GDP...ATSK........GPVERKVVRIVTPGTISD..EALLQe.......RQ.DNLLAAIWQd. 70 GDP...ATSK........GPVERKVVRIVTPGTISD..EALLQe.......RQ.DNLLAAIWQd. 71 GDP...ATSK........GPVERKVVRIVTPGTISD..EALLQe.......RQ.DNLLAAIWQd. 72 GDP...ATSK........GPVERKVVRIVTPGTISD..EALLQe.......RQ.DNLLAAIWQd. 73 GDP...TTSK........GPVERQIVRIVTPGTVSD..EALLPe.......RQ.DNLIAAVYQe. 74 GDP...GLAK........GLVERKVVRIVTPGTITD..EVLLEe.......RR.DTLLMALSRs. 75 GEV...GAGK........GPVERKVVRIVTPGTLTD..SALLEd.......KE.TNRIVAVSPd. 76 GEV...GAGK........GPVERKVVRIVTPGTLTD..SALLEd.......KE.TNRIVAVSPd. 77 SHP...V-PG........ELTQRKVIEIISPGTAVE..DDFLSq.......GF.SQYLATVCAs. 78 SN-...STSG........GPLEREVVEVITPGVIID..EDFLN........DDiNNYLVAISDy. 79 EEP...SKSK........KLIRREVTRVVTPGSIVE..DEFLS........ET.NNYMAVVSEe. 80 EEP...SKSK........KLIRREVTRVVTPGSIVE..DEFLS........ET.NNYMAVVSEe. 81 ---...----........------VTRVITPGTLID..ENFMNp.......YE.SNYILTVVFdp 82 IRPvddLSSK........NMYIRSVTRVITPGTLID..ENFMNp.......YE.SNYILTVVFdp 83 IRPvddLSSK........NMYIRSVTRVITPGTLID..ENFMNp.......YE.SNYILTVVF.. 84 KKK...DVADnea.....NKFYRRVTRIVTPGTFID..EAFENl.......RE.NTYLLNIEFpe 85 KKK...DVADnea.....NKFYRRVTRIVTPGTFID..EAFENl.......RE.NTYLLNIEFpe 86 EPA...EEAE........GLVRREVTQLLTPGTLTQ..EALLP........RE.ANYLAAIAT.. 87 EPA...EEAE........GLVRREVTQLLTPGTLTQ..EALLP........RE.ANYLAAIAT.. 88 EPA...EEAE........GLVRREVTQLLTPGTLTQ..EALLP........RE.ANYLAAIAT.. 89 EPA...EEAE........GLVRREVTQLLTPGTLTQ..EALLP........RE.ANYLAAIAT.. 90 EPA...EEAE........GLVRREVTQLLTPGTLLQ..ESLLP........RE.ANYLAAIAT.. 91 EPA...EEAE........GLVRREVTQLLTPGTLLQ..ESLLP........RE.ANYLAAIAT.. 92 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG..EDVNPlir16mtdTS.TNYLLCIYEek 93 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG..EDVNPlir16mtdTS.TNYLLCIYEek 94 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG..EDVNPlir16mtdTS.TNYLLCIYEek 95 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG..EDVNPlir16mtdTS.TNYLLCIYEek 96 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG..EDVNPlir16mtdTS.TNYLLCIYEek 97 ETA...ALKAigdnrs..SLFSRKLTALYTKSTLIG..EDVNPlik16mtdTS.TSYLLCISEnk 98 ETA...ALKAigdnrs..SLFSRKLTALYTKSTLIG..EDVNPlik16mtdTS.TSYLLCISEnk 99 ETA...AIKShganra..GPFFRGLSGLYTKATLEAa.EDISGgcv9egfgGQ.SNFLVCVVDer 100 ETA...AIKShganrt..GPFFRGLSALYTKATLEAa.EDISGgcg9egfgSQ.SNFLVCVVDer 101 ETA...AIKShganrt..GPFFRGLSALYTKATLEAa.EDISGgcg9egfgSQ.SNFLVCVVDer 102 ETA...AIKShganrt..GPFFRGLSALYTKATLEAa.EDISGgcg9egfgSQ.SNFLVCVVDer 103 ETA...ALKStsssrn..TLFDRRVARVLTKGTTLD..DSFFRfeq9hgtlQA.SQFILCVADnv 104 ETA...ALKStsssrn..TLFDRRVARVLTKGTTLD..DSFFRfeq9hgtlQA.SQFILCVADnv 105 ETS...AIKKhdpgasksSVFERKISNVFTKATFGV..NSTFVlrgkril.GD.TNSIWALSRdv 106 ETS...AIKKhdpgasksSVFERKISNVFTKATFGV..NSTFVlrgkril.GD.TNSIWALSRdv 140 150 160 170 180 19 | | | | | 1 a24ggqGIRVGFAALNTTLRTLTYAEYLDtlq.LTSLDALMAQCNLKELIYl....DKSRCRGGS 2 kqd...QRIIGVAFIDPILKKLGVSEFVDsda.YTNFEALIVQVGAKECII.....SQSGHESTN 3 kqd...QRIIGVAFIDPILKKLGVSEFVDsda.YTNFEALIVQVGAKECII.....SQSGHESTN 4 res...QLYVGLSFLDMTNRKLGLAEFPEdsr.FTNVESALVALGCKECLL.....PADCEKSID 5 hdg...RCVIGMAYVDLTRRVLGLAEFLDdsr.FTNLESSLIALGAKECIFpa...ESGKSNECK 6 hdg...RCVIGMAYVDLTRRVLGLAEFLDdsr.FTNLESSLIALGAKECIFpa...ESGKSNECK 7 kase..ARTVGVCFADASVRELGVSEFLDndl.YSNFEALLIQLGVKECIVtqdkgEKEKDPELA 8 i10segQRLVGVGYVDSTLRKLGVCEFPDndq.FSNLEALLVQIGPKECVMp....GGETAGDMG 9 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 10 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 11 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 12 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 13 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 14 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 15 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 16 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 17 i10vdgQRHVGVGYVDSTQRKLGLCEFPEndq.FSNLEALLIQIGPKECVLp....GGETTGDMG 18 i10vdgQRHVGVGYVDSTQRKLGLCEFPEndq.FSNLEALLIQIGPKECVLp....GGETTGDMG 19 i10vdgQRQVGVGDVDSTQRKLGLCEFPDndq.FSNLEALLIQIGPKECILp....GGETAGDMG 20 l11gggQRRVGVASVEQNDCKFQLLEFLDddf.FTELEATVVLLGPKECLL.....P-SIEGEYS 21 l11gggQRRVGVASVEQNDCKFQLLEFLDddf.FTELEATVVLLGPKECLL.....P-SIEGEYS 22 l11gggQRRVGVASVEQNDCKFQLLEFLDddf.FTELEATVVLLGPKECLL.....P-SIEGEYS 23 gdd...DNRVTLCAWDAGNVRIVISEYIDtps.FSQTEQCIFGLCPTEYILvn...EGSVAPKAK 24 ......----------------KLNKLPNn...FFRMSRAIERLKAMAGSH.....DSSMTEEDK 25 ......----------------KLNKLPNn...FFRMSRAIERLKAMAGSH.....DSSMTEEDK 26 ......----------------KLNKLPNn...FFRMSRAIERLKAMAGSH.....DSSMTEEDK 27 rdi...STRIGLCIINCNTGQMYLSDFMDsqi.YIRVVHKLQIYQPTEILI.....PSSSLAPTV 28 rdi...STRIGLCIINCNTGQMYLSDFMDsqi.YIRVVHKLQIYQPTEILI.....PSSSLAPTV 29 gla...RGEIGMASIDLKNPQIILSQFADntt.YAKVITKLKILSPLEIIM.....SNTACAVGN 30 gla...RGEIGMASIDLKNPQIILSQFADntt.YAKVITKLKILSPLEIIM.....SNTACAVGN 31 melqkcSTVYGFAFVDCAALRFWVGSISDdas.CAALGALLMQVSPKEVLY.....DSKGLSREA 32 melqkcSTVYGFAFVDCAALRFWVGSISDdas.CAALGALLMQVSPKEVLY.....DSKGLSREA 33 lassg.FQVFGFAFLDYAALKIWVGSVQDdds.SAALGALLMQVSPRELIY.....ETSGISKET 34 lassg.FQVFGFAFLDYAALKIWVGSVQDdds.SAALGALLMQVSPRELIY.....ETSGISKET 35 g21klnTKIFGAAFIDTATGELQMLEFEDdse.CTKLDTLMSQVRPMEVVM.....ERNNLSTLA 36 g21klnTKIFGAAFIDTATGELQMLEFEDdse.CTKLDTLMSQVRPMEVVM.....ERNNLSTLA 37 qsdne.EPSFGICFIDTSTGGFHMCEFTDdih.RTKLDTLLTQVRPKELIL.....EKSKISQKS 38 npetg.KSSYGVCMIDTTTAHIRIGQFEDddy.RSQLRTLLANVIVVQAIV.....ERGSISSTT 39 edssghTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKET 40 edssghTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKET 41 edssghTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKET 42 edssghTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKET 43 edssghTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKET 44 eetsghTRVYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQILF.....EKGNLSTET 45 eetsghTRVYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQILF.....EKGNLSTET 46 egt...CSRYGVCFIDTSIGDFHLGEFEDdkn.CSRLLTLVSHHMPVLFLN.....EKSALSQRT 47 e10ptaEHNFGVCLVDVATQKIILGQFKDdqd.CSALSCLLSEMRPVEIIK.....PAKVLSYAT 48 e10ptaEHNFGVCLVDVATQKIILGQFKDdqd.CSALSCLLSEMRPVEIIK.....PAKVLSYAT 49 ......GKSYLVSYLNLSVGEFIGAKVK-....EEELIDFLSKFNIREVLVk....KGEKLPEKL 50 ......GNHYYVGYLNLAVGEFLGAKVK-....IEELLDLLSKLNIKEILVk....KGEKLPEEL 51 ......GSLFGFACLDLSTGSFFIEECEN....TKELVDEICRLAPSEVLS.....CNKFYNKET 52 ......GSLFGFACLDLSTGSFFIEECEN....TKELVDEICRLAPSEVLS.....CNKFYNKET 53 ......GSLYGLSCLDLSIGTFLVAEYDN....TKDLIEAICRLAPTELLS.....HAKFYQKNE 54 ......GSLYGLSCLDLSTGTFLVAEYDN....TKDLIEAVYRLAPTELLS.....HAKFYQKNE 55 n.....KKTASICCVDLSTSKIFVINVP-....ETEILNELARLKSREILL.....SENLKSSNI 56 sgs...EPAYALAWIDISTGIFRLAETA-....ESRLLADILRIEPRELIL.....PDTVFHDPD 57 ......EDKWGLAHADISTGEFFTCQSSN....LDDLAVELLRLQPSEVLI.....PTSAPDIRN 58 ......EDKWGLAHADISTGEFFTCQSSN....LDDLAVELLRLQPSEVLI.....PTSAPDIRN 59 ......GEHWGLAYADSSTGDYWTSQSTG....LEGL--------------.....--------- 60 ......SNGYGLALSDLTTGENLAVLIER....LEDVISEIYSVGAREIVV.....SGSLDADTV 61 ......SNGYGLALSDLTTGENLAVLIER....LEDVISEIYSVGAREIVV.....SGSLDADTV 62 ......QPEIALSYCDVSTGELKVTHFND....EATLLNEITTINPNEVVI.....NDNISDNLK 63 ......GNQFGLAYMDLVTGDFYVTGLLD....FTLVCGEIRNLKAREVVL.....GYDLSEEEE 64 ......ERLFGLAILDITSGRFNVQEIQG....WENLLAELERLNPAELLY.....PDDWPAGLP 65 ......ERLFGLAVLDITSGRFSVQEIKG....WETLLAELERLNPAELLI.....PDDWPQGLP 66 ......ERLFGLAVLDITSGRFSVQEIKG....WETLLAELERLNPAELLI.....PDDWPQGLP 67 ......NGRFGYATMDITSGRFQLSEPQT....EEEMAAELQRTSPRELLF.....PEDFSPVHL 68 ......GKGYGYATLDISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMAL 69 ......GKGYGYATLDISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMAL 70 ......SKGFGYATLDISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMSL 71 ......SKGFGYATLDISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMSL 72 ......SKGFAYATLDISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMSL 73 ......KEKFGLATLDMTSGRFQLCEPAD....KETLRAELQRIAPVELLY.....CEEFNEMAA 74 ......KNCYGLAWADLAGGRFLVNEVNS....EEALEAELARLEPAELLLp....DEDAWPEYL 75 ......KKYIGLAWASLQSGEFKTKLTT-....VDKLDDELARLQAAEILL.....PDSKNAPQL 76 ......KKYIGLAWASLQSGEFKTKLTT-....VDKLDDELARLQAAEILL.....PDSKNAPQL 77 ......DATVAFSYLEVSTGAFFITSFPRaea.ADALQKEFGRVQPSEVLL.....SASVLRSLP 78 ......KDYYSFSYIDLSTSSLGIMFYENgf..FEKLKRDLEKYSPKEIIV.....SENFYYEYS 79 ......KGRYCTVFCDVSTGEVLVHESSD....EQETLDLLKNYSISQIIC.....PEHLKSSLK 80 ......KGRYCTVFCDVSTGEVLVHESSD....EQETLDLLKNYSISQIIC.....PEHLKSSLK 81 n22cfaDCKIGLSWLDLSTGEFFTQDSN-....LQRLAGDLTRISPREIVL.....DESLKSFTT 82 n22cfaDCKIGLSWLDLSTGEFFTQDSN-....LQRLAGDLTRISPREIVL.....DESLKSFTT 83 ......-----------------------....------------------.....--------- 84 n11adtSLKVGICWCDVSTGEIFVQQVY-....LRDLVSAITRIQPKEILL.....DERLLEFHI 85 n11adtSLKVGICWCDVSTGEIFVQQVY-....LRDLVSAITRIQPKEILL.....DERLLEFHI 86 ......GDGWGLAFLDVSTGEFKATLLKS....KSALYDELFRHRPAEVLL.....APELRENEA 87 ......GDGWGLAFLDVSTGEFKGTLLKS....KSALYDELFRHRPAEVLL.....APELRENEA 88 ......GDGWGLAFLDVSTGEFKGTLLKS....KSALYDELFRHRPAEVLL.....APELRENEA 89 ......GDGWGLAFLDVSTGEFKGTLLKS....KSALYDELFRHRPAEVLL.....APELRENEA 90 ......GDGWGLAFLDVSTGEFKGTVLKS....KSALYDELFRHRPAEVLL.....APELLENGA 91 ......GDGWGLAFLDVSTGEFKGTVLKS....KSALYDELFRHRPAEVLL.....APELLENGA 92 e11kkgNLSVGVVGVQPATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTE 93 e11kkgNLSVGVVGVQPATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTE 94 e11kkgNLSVGVVGVQPATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTE 95 e11kkgNLSVGVVGVQPATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTE 96 e11kkgNLSVGVVGVQPATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTE 97 e11kkgNIFIGIVGVQPATGEVVFDSFQDsas.RSELETRMSSLQPVELLL.....PSALSEQTE 98 e11kkgNIFIGIVGVQPATGEVVFDSFQDsas.RSELETRMSSLQPVELLL.....PSALSEQTE 99 v17asfDVRVGVVGVEISTGEVVHGEFNDnfm.RSGLEAVIL---------.....--------- 100 v16msfDVRVGVVGVEISTGEVVYEEFNDnfm.RSGLEAVILSLSPAELLL.....GQPLSQQTE 101 v16msfDVRVGVVGVEISTGEVVYEEFNDnfm.RSGLEAVILSLSPAELLL.....GQPLSQQTE 102 v16msfDVRVGVVGVEISTGEVVYEEFNDnfm.RSGLEAVILSLSPAELLL.....GQPLSQQTE 103 d10ksgRVQVGLIAIQLSSGTTVYDHFQDdfl.RSELQTRLSHFQPCELIY.....SNKLSSESV 104 d10ksgRVQVGLIAIQLSSGTTVYDHFQDdfl.RSELQTRLSHFQPCELIY.....SNKLSSESV 105 hqgk..VAKYSLISVNLNNGEVVYDEFEEpnlaDEKLQIRIKYLQPIEVLV.....NTDDLPLHV 106 hqgk..VAKYSLISVNLNNGEVVYDEFEEpnlaDEKLQIRIKYLQPIEVLV.....NTDDLPLHV 0 200 210 220 230 2 | | | | | 1 NSDRGGGAAGVCRRKRarr66rvpEDRLALSNCPLASRAIEYLVSNIIDNFDATN........HR 2 GNSAVSINTAEINRLRnii36pvtHALVPELGLQLAMASCNALLRYLGPALLNPD........ME 3 GNSAVSINTAEINRLRnii36pvtHALVPELGLQLAMASCNALLRYLGPALLNPD........ME 4 LNPLQDVISNCNVLLTekk25svePVRDLLSQFDYALGPLGALLSYAELLADDTN........YG 5 SLYDSLERCAVMITERkkh23niePVRDLVSGFDLATPALGALLSFSELLSNEDN........YG 6 SLYDSLERCAVMITERkkh23niePVRDLVSGFDLATPALGALLSFSELLSNEDN........YG 7 KLRQIIDNCGVAIAERsag23eraASLLPQTDLKLAMGSASALIKYLGILHDPSN........FG 8 KLRQIVKRGGILITDRkra27qvtSAALPEMEKQVAMSALAAVMKYLELLSDESN........FG 9 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 10 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 11 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 12 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 13 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 14 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 15 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 16 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 17 KLRQVIQRGGILITERkra27qinSAALPEMENQVAVSSLSAVIKFLELLSDDSN........FG 18 KLRQVIQRGGILITERkra27qinSAALPEMENQVAVSSLSAVIKFLELLSDDSN........FG 19 KLRQVIQRGGILITERkri27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 20 AVKTLLDRNGVMITMPkks25qedATGLKELQLQLASNALKTAIKYLDLVNDAGN........LG 21 AVKTLLDRNGVMITMPkks25qedATGLKELQLQLASNALKTAIKYLDLVNDAGN........LG 22 AVKTLLDRNGVMITMPkks25qedATGLKELQLQLASNALKTAIKYLDLVNDAGN........LG 23 KIASMFTRMEVHNKQQlkp13iesVHLDYKDEAEKQNENIKECLQILHSNAADEY........SI 24 YIIIKMR---------........----FDIEAVNMIRSFGALLLFLDETRMGVTddplsvtsPI 25 YIIIKMR---------........----FDIEAVNMIRSFGALLLFLDETRMGVTddplsvtsPI 26 YIIIKMR---------........----FDIEAVNMIRSFGALLLFLDETRMGVTddplsvtsPI 27 SKLATMIKFNVAETVKiee29kkdLKIEEIIDKTFALCAASAAISYMEEIISKSSrn......-L 28 SKLATMIKFNVAETVKiee29kkdLKIEEIIDKTFALCAASAAISYMEEIISKSSrn......-L 29 STKLFTLITENFKNVNftt27efsTVLMEVQSKYYCLAAVAALLKYVEFIQNSVY........AP 30 STKLFTLITENFKNVNftt27efsTVLMEVQSKYYCLAAVAALLKYVEFIQNSVY........AP 31 QKALRKYTLTGSTAVQlap34swnCAVDGLNECDVALSALGELINHLSRLKLEDVlk......HG 32 QKALRKYTLTGSTAVQlap34swnCAVDGLNECDVALSALGELINHLSRLKLEDVlk......HG 33 QRTIRKYASAGSVKMQltp33swlSALDCTMNQDVVICALGGLIGHLTRLMLHDAlk......NG 34 QRTIRKYASAGSVKMQltp33swlSALDCTMNQDVVICALGGLIGHLTRLMLHDAlk......NG 35 NKIVKFNSAPNAIFNEvka32pevLKSYYDTGKKVGFSAFGGLLYYLKWLKLDKN........LI 36 NKIVKFNSAPNAIFNEvka32pevLKSYYDTGKKVGFSAFGGLLYYLKWLKLDKN........LI 37 IRAIKYCVSSSSIWNFikp32apkILKSYLSEKPLAISAFGALFWYLRQLKLDKD........MC 38 KSIINGILFSVPVEHLlpk41dssILPKPSTDWQLALSAFGAIFWYLRDSLIDVD........ML 39 KTILKSSLSCSLQEGLipg47sdsIGLTPGEKSELALSALGGCVFYLKKCLIDQE........LL 40 KTILKSSLSCSLQEGLipg47sdsIGLTPGEKSELALSALGGCVFYLKKCLIDQE........LL 41 KTILKSSLSCSLQEGLipg47sdsIGLTPGEKSELALSALGGCVFYLKKCLIDQE........LL 42 KTILKSSLSCSLQEGLipg47sdsIGLTPGEKSELALSALGGCVFYLKKCLIDQE........LL 43 KTILKSSLSCSLQEGLipg47sdsIGLTPGEKSELALSALGGCVFYLKKCLIDQE........LL 44 KTVLKGSLSSCLQEGLipg45sdsVGLTPGEESELALSALGGIVFYLKKCLIDQE........LL 45 KTVLKGSLSSCLQEGLipg45sdsVGLTPGEESELALSALGGIVFYLKKCLIDQE........LL 46 QQIVRTVLGGILKEPVpgn44mdhLGLTPNDNYKLALKALGQCIFFIHKCKLEPK........VL 47 ERTIVRQTRNPLVNNLvpl50mlsELATEDKNGSLALSALGGAIYYLRQAFLDES........LL 48 ERTIVRQTRNPLVNNLvpl50mlsELATEDKNGSLALSALGGAIYYLRQAFLDES........LL 49 EKVLKLHITELEEEFFeeg14gvpSIKAFGFQDEDLSLSLGAVYRYAKATQKSFT........PL 50 EKVLKVYVSELEEEFFeeg14gvlSLQAFGFEEDTYSLPLGAVYKYAKTTQKGYT........PL 51 AIVMQLQQHLKLTLSTyad23vasLDGFGLKGLVPAINAAGGLLSYIQDKLLLPTk.......HI 52 AIVMQLQQHLKLTLSTyad23vasLDGFGLKGLVPAINAAGGLLSYIQDKLLLPTk.......HI 53 AVIKQLQQHLRITLSEyvs23vssLDGFGLQGLVPAINAAGALLSYIQDKLLLPIs.......HL 54 PVVKQLQQHLRITLSEhvs23vssLDGFGLQGLVPAINAAGALLSYIQDKLLLPIs.......HL 55 SDSI-LKQFNCRITYQvds21kirDIKGIGEISNSQICAIGSILEYLSLTQKQNIp.......HL 56 LRPVFDVLGRVAVPQPavl20gvgTLDGFGSFSRAELAAASAAVSYVEKTQLQERp.......AL 57 ILRPGEPSEHIPKQLPtsf30vksLEGMGCEGLPLAIRAAGGLLEYIEDTQKAHVv.......PI 58 ILRPGEPSEHIPKQLPtsf30vksLEGMGCEGLPLAIRAAGGLLEYIEDTQKAHVv.......PI 59 ----------------........-------------------------------........-- 60 AQLRERCGATISIEDGetdeh...VTIIEHLNNEDITKTFLRLYTYLKRTQKRSLd.......HL 61 AQLRERCGATISIEDGetdeh...VTIIEHLNNEDITKTFLRLYTYLKRTQKRSLd.......HL 62 RQINMVTETITVRETLsse.....IYSVNQTEHKLMYQATQLLLDYIHHTQKRDLs.......HI 63 QILSRQMNLVLSYEKEsfed....LHLLDLRLATVEQTASSKLLQYVHRTQMRELn.......HL 64 LEKRRGAHRRAPWDFDfds16tqdLKGFGCDGLGLAIGAAGCLLAYARETQRTALp.......HL 65 AEKRRGVRRRAPWDFDrds16tqdLKGFGCQNLTLAIGAAGCLLAYAKETQRTALp.......HL 66 AEKRRGVRRRAPWDFDrds16tqdLKGFGCQNLTLAIGAAGCLLAYAKETQRTALp.......HL 67 MASRQGNRRRPIWEFEldt16trdLVGFGVEQAKLGLCAAGCLIQYVKDTQRTALp.......HI 68 IEGRRGLRRRPLWEFEidt16trdLVGFGVENASRGLCAAGCLLQYVKDTQRTSLp.......HI 69 IEGRRGLRRRPLWEFEidt16trdLVGFGVENASRGLCAAGCLLQYVKDTQRTSLp.......HI 70 IEGRRGLRRRPLWEFEidt16trdLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLp.......HI 71 IEGRRGLRRRPLWEFEidt16trdLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLp.......HI 72 IEGRRGLRRRPLWEFEidt16trdLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLp.......HI 73 IEHCKGLRRRPIWEFElst16tkdLRAFGVEKSPLGLSAAGCLLQYAKETQRTALp.......HI 74 QQRNGVRRRPPWLFDAdsg15lhdLSGFGIENNPQATAAAGALLGYIEETQKQRLp.......HL 75 QTASGVTRLNAWQFAAdag17dlrGFGLDGKEHAVAIGAAGALLNYIRLTQNLMPq.......HL 76 QTASGVTRLNAWQFAAdag17dlrGFGLDGKEHAVAIGAAGALLNYIRLTQNLMPq.......HL 77 ELAAILSLYPRLVRTTgad23trnLDCLTLLPHSPDLAAAGALIAYLEETTRHPLs.......HV 78 EKLNLSRFLINRVPTWhld19ilgLSSLGFDEEKPYYISIFLIINHIKNNLKNLLs.......NI 79 ERFPGVYTETISEWYFsdl12ynlKDIHHFELSPLALKALAALIKYVKYTMIAEDl.......NL 80 ERFPGVYTETISEWYFsdl12ynlKDIHHFELSPLALKALAALIKYVKYTMIGEDl.......NL 81 HPIYSFIQERKYFLSYven19keiDPSFIKYCTKLEVTAGCTLISYIADRLQNSHp.......NI 82 HPIYSFIQERKYFLSYven19keiDPSFIKYCTKLEVTAGCTLISYIADRLQNSHp.......NI 83 ----------------........-------------------------------........-- 84 ESGTWYPELVELKKFFiky31erqLKIQFQTFTQKELAALRNTLIYVSNHLPDFSi.......NF 85 ESGTWYPELVELKKFFiky31erqLKIQFQTFTQKELAALRNTLIYVSNHLPDFSi.......NF 86 FVAQFRKRFPVMLSEA........PFDPEGEAPLALSRARGALLAYARATQGGAL........SV 87 FVAEFRKRFPVMLSEA........PFEPQGEGPLALRRAQGALLAYARATQGGAL........SV 88 FVAEFRKRFPVMLSEA........PFEPQGEGPLALRRAQGALLAYARATQGGAL........SV 89 FVAEFRKRFPVMLSEA........PFEPQGEGPLALRRAQGALLAYARATQGGAL........SV 90 FLDEFRKRFPVMLSEA........PFEPEGEGPLALRRARGALLAYAQRTQGGAL........SL 91 FLDEFRKRFPVMLSEA........PFEPEGEGPLALRRARGALLAYAQRTQGGAL........SL 92 MLIQRATNVRLKTVRKlkt55gsqSLSGVINLEKPVICALAAVIRYLKEFNLEKM........LS 93 MLIQRATNVR------........-------------------------------........-- 94 MLIQRATNVSVRDDRIrve34gsqSLSGVINLEKPVICALAAVIRYLKEFNLEKM........LS 95 MLIQRATNVSVRDDRIrve34gsqSLSGVINLEKPVICALAAVIRYLKEFNLEKM........LS 96 MLIQRATNVSVRDDRIrve34gsqSLSGVINLEKPVICALAAVIRYLKEFNLEKM........LS 97 ALIHRATSVSVQDDRIrve34gsqIISGIVNLEKPVICSLAAIIKYLKEFNLEKM........LS 98 ALIHRATSVSVQDDRIrve34gsqIISGIVNLEKPVICSLAAIIKYLKEFNLEKM........LS 99 ----------------........-------------------------------........-- 100 KFLVAHAGPTSNVRVEras46sclTVHTIMNMPHLTVQALALTFCHLKQFGFERI........LY 101 KFLVAHAGPTSNVRVEras46sclTVHTIMNMPHLTVQALALTFCHLKQFGFERI........LY 102 KFLVAHAGPTSNVRVEras46sclTVQTIMNMPHLTVQALALTFCHLKQFGFERI........LY 103 ALLNHYVSTEKTCGRVvrv36ielHMEKVKSLHSLSIICLDMAISYLMEFSLEDL........FV 104 ALLNHYVSTEKTCGRVvrv36ielHMEKVKSLHSLSIICLDMAISYLMEFSLEDL........FV 105 AKFFKDISCPLIHKQEydl12aikVMNEKIQLSPSLIRLVSKLYSHMVEYNNEQV........ML 106 AKFFKDISCPLIHKQEydl12aikVMNEKIQLSPSLIRLVSKLYSHMVEYNNEQV........ML 40 250 260 270 28 | | | | 1 AFy.......LKHTIP........STFMKLDTAAIQALHIIHQKPEArgslp...TSVYSWLNRC 2 DDren9rklhLYHHNL........EQYMRLDIAAVRSLNLLPPPNGNahkt....MSLYGLLNHC 3 DDren9rklhLYHHNL........EQYMRLDIAAVRSLNLLPPPNGNahkt....MSLYGLLNHC 4 NYt.......IEKYNL........NCYMRLDSAAVRALNIAEGKTDVnkn.....FSLFGLMNRT 5 NFt.......IRRYDI........GGFMRLDSAAMRALNVMESKTDAnkn.....FSLFGLMNRT 6 NFt.......IRRYDI........GGFMRLDSAAMRALNVMESKTDAnkn.....FSLFGLMNRT 7 QYq.......LYQHDL........AQFMKLDAAALKALNLMPGARDGakn.....MSLYGLLNHC 8 QFv.......MTNFDL........SQYMKLDNAAVGALNLFPGSAEDtsgt....QSLAGLLNKC 9 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 10 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 11 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 12 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 13 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 14 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 15 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 16 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 17 QFe.......LATFDF........SQYMKLDMAAVRALNLFQGSVEDttgs....QSLAALLNKC 18 QFe.......LATFDF........SQYMKLDMAAVRALNLFQGSVEDttgs....QSLAALLNKC 19 QFe.......LATFDF........SQYMKLDMAAVRALNLFQGSVEDttgs....QSLAAFLNKC 20 HYe.......IKQLDL........NRFVHLDSAAVAALNIMPKPGTHpsmpsyrwQSVLGVLDHC 21 HYe.......IKQLDL........NRFVHLDSAAVAALNIMPKPGTHpsmpsyrwQSVLGVLDHC 22 HYe.......IKQLDL........NRFVHLDSAAVAALNIMPKPGTHpsmpsyrwQSVLGVLDHC 23 SEkys.....IFNYGT........HGNMLIDSCAVEALELFQLNYNYleksnn..LTLYNVLNKC 24 KS........IKTFTL........GNLVEIDFNTIQALDILPKETENkktfgqg.RSLYQLMDKC 25 KS........IKTFTL........GNLVEIDFNTIQALDILPKETENkktfgqg.RSLYQLMDKC 26 KS........IKTFTL........GNLVEIDFNTIQALDILPKETENkktfgqg.RSLYQLMDKC 27 NAfrklr...IQFEGT........ENTMLIDSKTVRGLELVENKLDKng......ISLWKFLDTT 28 NAfrklr...IQFEGT........ENTMLIDSKTVRGLELVENKLDKng......ISLWKFLDTT 29 KSlk......ICFQGS........EQTAMIDSSSAQNLELLINNQDYrnn.....HTLFGVLNYT 30 KSlk......ICFQGS........EQTAMIDSSSAQNLELLINNQDYrnn.....HTLFGVLNYT 31 DI........FPYQVY........RGCLRIDGQTMVNLEIFNNSCDGvlq.....GPLNKYLENC 32 DI........FPYQVY........RGCLRIDGQTMVNLEIFNNSCDGgps.....GTLYKYLDNC 33 EV........LPYHVY........KTCLRMDGQTLVNLEIFINNFNGgss.....GTLYKHLNHC 34 EV........LPYHVY........KTCLRMDGQTLVNLEIFINNFNGgss.....GTLYKHLNHC 35 SMknike...YDFVKS........QHSMVLDGITLQNLEIFSNSFDGsdk.....GTLFKLFNRA 36 SMknike...YDFVKS........QHSMVLDGITLQNLEIFSNSFDGsdk.....GTLFKLFNRA 37 SMgnfde...YDASQQ........STSLLMNGQTLKNLEIFSNSFDGgse.....GTLFHLLCRC 38 SMrn......VTIYNSnsm15dwnGKNLILDGTALENLNIVPNGRDShl......TSLYYVINKC 39 SM........ANFEEYipl20tkaYQRMVLDAVTLNNLEIFLNGTNGste.....GTLLERVDTC 40 SM........ANFEEYipl20tkaYQRMVLDAVTLNNLEIFLNGTNGste.....GTLLERVDTC 41 SM........ANFEEYipl20tkaYQRMVLDAVTLNNLEIFLNGTNGste.....GTLLERVDTC 42 SM........ANFEEYipl20tkaYQRMVLDAVTLNNLEIFLNGTNGste.....GTLLERVDTC 43 SM........ANFEEYipl20tkaYQRMVLDAVTLNNLEIFLNGTNGste.....GTLLERVDTC 44 SM........ANFEEYfpl20tkaSQRMVLDAVTLNNLEIFLNGTNGste.....GTLLERLDTC 45 SM........ANFEEYfpl20tkaSQRMVLDAVTLNNLEIFLNGTNGste.....GNLLERLDTC 46 PMar......YQLY--vpp18tlrRSHMVLDATTLSNLRII---GEE........HSLLSTLDHC 47 RF........AKFESLpyc10vneKQHMVLDAAALENLEIFENSRNGgys.....GTLYAQLNQC 48 RF........AKFESLpyc10vneKQHMVLDAAALENLEIFENSRNGgys.....GTLYAQLNQC 49 IPk.......PKPYVD........EGYVKLDLKAVKGLEITESIEGRkd......LSLFKVVDRT 50 IPr.......PKPYRD........EGFVRLDIKAIKGLEILESLEGRkd......ISLFKVIDRT 51 AI........PQTRGK........QQKLLIDTASQVNLELLAPLNDPqgk.....NSLLRIMDHT 52 AI........PQTRGK........QQKLLIDTASQVNLELLAPLNDPqgk.....NSLLRIMDHT 53 SI........PKIYGQ........QKHLLIDKASQTNLELLSPIHGEhgk.....GSLLQVMERT 54 SI........PKIYGQ........HKHLLIDKASQTNLELLSAIHGEhgk.....GSLLQVMERT 55 PI........PKIINF........HNYMTIDFSTRRNLEIVTNLQGNly......GSVLNTLNHT 56 GI........PERESA........ASTLFIDPATRANLELAKTLSGSrd......GSLLKSLDRT 57 QP........LKTYGL........TDFLVLDHQTRRNLEINQTVRDGsfh.....GSLLWALDRT 58 QP........LKTYGL........TDFLVLDHQTRRNLEINQTVRDGsfh.....GSLLWALDRT 59 --........------........-----------------------........---------- 60 QP........VQVYEL........EEAMKIDLYSKRNLELTETIRSKnkk.....GSLLWLLDET 61 QP........VQVYEL........EEAMKIDLYSKRNLELTETIRSKnkk.....GSLLWLLDET 62 ED........VVQYAA........IDYMKMDFYAKRNLELTESIRLKskk.....GTLLWLMDET 63 KP........VIRYEI........KDFLQMDYATKASLDLVENARSGkkq.....GSLFWLLDET 64 RG........LRHERL........DDTVILAGASRRNLELDVNLSGGrd......NTLQSVIDRC 65 RS........LRHDRL........DDTVILDGASRRNLELDINLSGGre......NTLQSVVDRC 66 RS........LRHDRL........DDTVILDGASRRNLELDINLSGGre......NTLQSVVDRC 67 RS........LTWDRQ........DQSVILDAATRRNLELTHNLAGGtd......NTLAEVLDHC 68 RS........ITMERQ........QDSIIMDAATRRNLEITQNLAGGve......NTLAAVLDCT 69 RS........ITMERQ........QDSIIMDAATRRNLEITQNLAGGve......NTLAAVLDCT 70 RS........ITMERE........QDSIIMDAATRRNLEITQNLAGGae......NTLASVLDCT 71 RS........ITMERE........QDSIIMDAATRRNLEITQNLAGGae......NTLASVLDCT 72 RS........ITMERE........QDSIIMDAATRRNLEITQNLAGGae......NTLASVLDCT 73 QS........ISLIQN........QDCIQLDAATRRNLELTQNLAGGte......NTLASVLDKC 74 TS........ITMETV........GEAITMNAATRRHLELDTRVDGEsr......HTLLGVLDST 75 DG........LSLETD........SQYIGMDAATRRNLEITQTLSGKks......PTLMSTLDLC 76 DG........LSLETD........SQYIGMDAATRRNLEITQTLSGKks......PTLMSTLDLC 77 SA........ITRYHI........HDFVEIDDATRKNLEILQNLHDStha.....HSLFETLNYT 78 DK........IDINND........SSYMFLDDVTQVNLELVKNNNDFssq.....YSLYSVLNDC 79 KP........PLLISQ........RDYMILDSATVENLSLIPGDRGKn.......--LFDVLNNT 80 KP........PLLISQ........RDYMILDSATVENLSWIPGDRGKn.......--LFDVLNNT 81 QP........PIRVSL........NEYMIIGESAMKGLEIRSSLYQNryt.....GSLLHAINKT 82 QP........PIRVSL........NEYMIIGESAMKGLEIRSSLYQNryt.....GSLLHAINKT 83 --........------........-----------------------........---------- 84 QI........PQRQLA........TAIMQIDSRTSTALELHSTVRDNnkk.....GSLLSSIRRT 85 QI........PQRQLA........TAIMQIDSRTSTALELHSTVRDNnkk.....GSLLSSIRRT 86 RP........FRLYDP........GAIVRLPEASLKALEVFEPLRGQ........DTLFGVLDET 87 RP........FRLYDP........GAFVRLPEASLKALEVFEPLRGQ........DTLFGVLDET 88 RP........FRLYDP........GAFVRLPEASLKALEVFEPLRGQ........DTLFGVLDET 89 RP........FRLYDP........GAFVRLPEASLKALEVFEPLRGQ........DTLFGVLDET 90 QP........FRFYDP........GAFMRLPEATLRALEVFEPLRGQ........DTLFSVLDET 91 QP........FRFYDP........GAFMRLPEATLRALEVFEPLRGQ........DTLFSVLDET 92 KPesf.....KQLSSG........MEFMRINGTTLRNLEILQNQTDMktk.....GSLLWVLDHT 93 --........------........-----------------------........---------- 94 KPesf.....KQLSSG........MEFMRINGTTLRNLEILQNQTDMktk.....GSLLWVLDHT 95 KPesf.....KQLSSG........MEFMRINGTTLRNLEMVQNQTDMktk.....GSLLWVLDHT 96 KPesf.....KQLSSG........MEFMRINGTTLRNLEMVQNQTDMktk.....GSLLWVLDHT 97 KPenf.....KQLSSK........MEFMTINGTTLRNLEILQNQTDMktk.....GSLLWVLDHT 98 KPenf.....KQLSSK........MEFMTINGTTLRNLEILQNQTDMktk.....GSLLWVLDHT 99 --........------........-----------------------........---------- 100 QGas......FRSLSS........NTEMTLSANTLQQLEVVKNNSDGses.....GSLFHNMNHT 101 QGas......FRSLSS........NTEMTLSANTLQQLEVVKNNSDGses.....GSLFHNMNHT 102 QGas......FRSLSS........NTEMTLSANTLQQLEVVKNNSDGses.....GSLFHNMNHT 103 ASnf......YQPFDS........ISSMVLSKQALEGLELFVNQTDHtpv.....GSLFWVLDRT 104 ASnf......YQPFDS........ISSMVLSKQALEGLELFVNQTDHtpv.....GSLFWVLDRT 105 IPsi......YSPFAS........KIHMLLDPNSLQSLDIFTHDGGK........GSLFWLLDHT 106 IPsi......YSPFAS........KIHMLLDPNSLQSLDIFTHDGGK........GSLFWLLDHT 0 290 300 | | | 1 VT.GMGSRMMRQWLLQPLRN-- 2 RT.AMGARNLRRWIVQPLLD-- 3 RT.AMGARNLRRWIVQPLLD-- 4 CTvGMGKRLLNRWLKQPLLD-- 5 CTaGMGKRLLHMWLKQPLVD-- 6 CTaGMGKRLLHMWLKQPLVD-- 7 KT.PVGSRLLSQWLKQPLMN-- 8 KT.PQGQRLVNQWIKQPLMDKN 9 KT.PQGQRLVNQWIKQPLMDKN 10 KT.PQGQRLVNQWIKQPLMDKN 11 KT.PQGQRLVNQWIKQPLMDKN 12 KT.PQGQRLVNQWIKQPLMDKN 13 KT.PQGQRLVNQWIKQPLMDKN 14 KT.PQGQRLVNQWIKQPLMDKN 15 KT.PQG---------------- 16 KT.PQGQRLVNQWIKQPLMDKN 17 KT.AQGQRLVNQWIKQPLMDRN 18 KT.AQGQRLVNQWIKQPLMDRN 19 KT.AQGQRLVSQWIKQPLMDKN 20 RT.PQGHRLMGQWVKQPLRSRN 21 RT.PQGHRLMGQWVKQPLRSRN 22 RT.PQGHRLMGQWVKQPLRSRN 23 KT.LPGEKLLRDWLSRPLC--- 24 RS.TVGKKCLRKWFRNPTTDRD 25 RS.TVGKKCLRKWFRNPTTDRD 26 RS.TVGKKCLRKWFRNPTTDRD 27 ST.KMGQRSLRNSILQPLTDRG 28 ST.KMGQRSLRNSILQPLTDRG 29 KT.PGGSRRLRSNILEPLVD-- 30 KT.PGGSRRLRSNILEPLVD-- 31 VS.PTGKRLLRNWICHPLKD-- 32 VS.PTGKRLLRNWICHPLKD-- 33 VT.ASGKRMLRRWICHPLKD-- 34 VT.ASGKRMLRRWICHPLKD-- 35 IT.PMGKRMMKKWLMHPLLRKN 36 IT.PMGKRMMKKWLMHPLLRKN 37 VT.PFGKRLFHTWLCHPLR--- 38 ST.PFGRRLLRSWLLQPTCD-- 39 HT.PFGKRLLKQWLCAPLCN-- 40 HT.PFGKRLLKQWLCAPLCN-- 41 HT.PFGKRLLKQWLCAPLCN-- 42 HT.PFGKRLLKQWLCAPLCN-- 43 HT.PFGKRLLKQWLCAPLCN-- 44 HT.PFGKRLLKQWLCAPLCS-- 45 HT.PFGKRLLKQWLCAPLCS-- 46 CT.KFGKRLLHHWLCAPSCD-- 47 IT.ASGKRLLKTWLARPLYN-- 48 IT.ASGKRLLKTWLARPLYN-- 49 LT.GMGRRRLRFRLLNPFR--- 50 LT.GMGRRRLKFRLLSPFRSRE 51 ST.PMGGRLLRQILISPFYN-- 52 ST.PMGGRLLRQILISPFYN-- 53 ST.PMGGRLLRNTLINPFYD-- 54 ST.PMGGRLLRNTLVNPFYD-- 55 VT.TQGGRLLYHFLSSPLTN-- 56 MT.SGGARLLAERLMSPLTD-- 57 ST.TMGSRALRRWLLQPLLD-- 58 ST.TMGSRALRRWLLQPLLD-- 59 --.------------------- 60 KT.AMGGRLLKQWIDRPLI--- 61 KT.AMGGRLLKQWIDRPLI--- 62 KT.PMGARRLKQWIDRPLISKE 63 KT.AMGMRLLRSWIHRPLIDKE 64 QT.AMGSRLLGRWLNRPLRDR- 65 QT.AMASRLMSRWLNRPLRDR- 66 QT.AMASRLMSRWLNRPLRDR- 67 AT.PMGSRMLKRWIHQPMRD-- 68 VT.PMGSRMLKRWLHMPVRN-- 69 VT.PMGSRMLKRWLHMPVRN-- 70 VT.PMGSRMLKRWLHMPVRD-- 71 VT.PMGSRMLKRWLHMPVRD-- 72 VT.PMGSRMLKRWLHMPV---- 73 VT.PMGSRLLKRWIHQPVRD-- 74 VT.PMGGRLLRRWLHRPLR--- 75 AT.HMGSRLLALWLHHPLRNR- 76 AT.HMGSRLLALWLHHPLRNR- 77 HT.AMGTRLLRYWLHHPLRS-- 78 KT.AMGKRLLREFILNPILN-- 79 ET.PMGARLLKKWILHPLVDRK 80 ET.PMGARLGKKWILHPLVDRK 81 VT.KSGSRLLTRRLCAPST--- 82 VT.KSGSRLLTRRLCAPST--- 83 --.------------------- 84 VT.PSGTRLLSQWLSGPSLD-- 85 VT.PSGTRLLSQWLSGPSLD-- 86 RT.APGRRLLQAWLRHPLLERG 87 RT.APGRRLLQAWLRHPLLERG 88 RT.APGRRLLQAWLRHPLLERG 89 RT.APGRRLLQAWLRHPLLERG 90 RT.APGRRLLQSWLRHPLLDRG 91 RT.APGRRLLQSWLRHPLLDRG 92 KT.SFGRRKLKNWVTQPLL--- 93 --.------------------- 94 KT.SFGRRKLKNWVTQPLL--- 95 KT.SFGRRKLKNWVTQPLL--- 96 KT.SFGRRKLKNWVTQPLL--- 97 KT.SFGRRKLKKWVTQPLL--- 98 KT.SFGRRKLKKWVTQPLL--- 99 --.------------------- 100 LT.VYGSRLLRHWVTHPLCDRN 101 LT.VYGSRLLRHWVTHPLCDRN 102 LT.VYGSRLLRHWVTHPLCDRN 103 YT.RFGQRMLQRWLQKPLVDKE 104 YT.RFGQRMLQRWLQKPLVDKE 105 RT.SFGLRMLREWILKPLVD-- 106 RT.SFGLRMLREWILKPLVD--