a2m2html output for file tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1999.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0116-1-300 MutS, Thermus Aquaticus
- gi|79102|pir||A28668_7:319 DNA mismatch repair protein mutS - Salmonella typhimurium (Salmonella typhimurium)
- gi|154188|gb|AAA27167.1| (M18965) mismatch repair protein (MutS) [Salmonella typhimurium] (Salmonella typhimurium)
- gi|565092|gb|AAA80578.1| (U16303) DNA mismatch repair protein [Salmonella typhimurium] (Salmonella typhimurium)
- gi|417330|sp|P10339|MUTS_SALTY_7:319 DNA MISMATCH REPAIR PROTEIN MUTS (Salmonella typhimurium)
- gi|127556|sp|P23909|MUTS_ECOLI_6:317 DNA MISMATCH REPAIR PROTEIN MUTS (Escherichia coli)
- gi|2121105|pir||I54964 DNA mismatch repair protein - Escherichia coli (Escherichia coli)
- gi|146906|gb|AAA24188.1| (M64730) DNA mismatch repair protein [Escherichia coli] (Escherichia coli)
- gi|882626|gb|AAA69243.1| (U29579) DNA mismatch repair protein [Escherichia coli] (Escherichia coli)
- gi|1789089|gb|AAC75775.1| (AE000357) methyl-directed mismatch repair [Escherichia coli] (Escherichia coli)
- gi|4887554|emb|CAB43497.1|_6:317 (AJ006210) mismatch repair protein [Escherichia coli] (Escherichia coli)
- gi|1171081|sp|P44834|MUTS_HAEIN_3:317 DNA MISMATCH REPAIR PROTEIN MUTS (Haemophilus influenzae)
- gi|1074024|pir||G64087 DNA mismatch repair protein mutS - Haemophilus influenzae (strain Rd KW20) (Haemophilus influenzae)
- gi|1573708|gb|AAC22364.1| (U32753) DNA mismatch repair protein (mutS) [Haemophilus influenzae Rd] (Haemophilus influenzae Rd)
- gi|9654962|gb|AAF93703.1|_7:322 (AE004139) DNA mismatch repair protein MutS [Vibrio cholerae] (Vibrio cholerae)
- gi|1592569|gb|AAB97931.1|_6:315 (U69873) DNA mismatch repair protein [Escherichia coli] (Escherichia coli)
- gi|127555|sp|P27345|MUTS_AZOVI_3:315 DNA MISMATCH REPAIR PROTEIN MUTS (Azotobacter vinelandii)
- gi|1073104|pir||A53296 DNA mismatch repair protein MutS - Azotobacter vinelandii (Azotobacter vinelandii)
- gi|142306|gb|AAA16868.1| (M63007) mutS [Azotobacter vinelandii] (Azotobacter vinelandii)
- gi|7387928|sp|Q9ZIX6|MUTS_THECA_8:305 DNA MISMATCH REPAIR PROTEIN MUTS (Thermus caldophilus)
- gi|4102012|gb|AAD01407.1| (AF007553) mismatch repair protein [Thermus caldophilus] (Thermus caldophilus)
- gi|7229490|gb|AAF42850.1|_4:315 (AF220055) mismatch repair protein MutS [Pseudomonas aeruginosa] (Pseudomonas aeruginosa)
- gi|7108493|gb|AAF36440.1|AF126491_1_4:315 (AF126491) mismatch repair system component MutS [Pseudomonas aeruginosa] (Pseudomonas aeruginosa)
- gi|2497995|sp|Q56215|MUTS_THEAQ_2:300 DNA MISMATCH REPAIR PROTEIN MUTS (Thermus aquaticus)
- gi|1203807|gb|AAC43637.1| (U33117) MutS [Thermus aquaticus] (Thermus aquaticus)
- gi|1588400|prf||2208391A MutS-like protein [Thermus aquaticus] (Thermus aquaticus)
- gi|7328284|emb|CAB82466.1|_3:301 (Y18631) MutS protein [Staphylococcus aureus] (Staphylococcus aureus)
- gi|7512474|pir||JC5839_395:784 GTBP-N protein - human (Homo sapiens)
- gi|2696086|dbj|BAA23674.1| (D89645) GTBP-N [Homo sapiens] (Homo sapiens)
- gi|6754744|ref|NP_034960.1|_394:781 mutS homolog 6 (E. coli) (Mus musculus)
- gi|2665637|gb|AAB88445.1| (AF031087) mismatch repair protein MSH6 [Mus musculus] (Mus musculus)
- gi|7512473|pir||JC5840_395:784 GTBP-ALT protein - human (Homo sapiens)
- gi|2662381|dbj|BAA23675.1| (D89646) GTBP-ALT [Homo sapiens] (Homo sapiens)
- gi|2696085|dbj|BAA23673.1| (D89645) GTBP-ALT [Homo sapiens] (Homo sapiens)
- gi|1709123|sp|P52701|MSH6_HUMAN_395:784 DNA MISMATCH REPAIR PROTEIN MSH6 (MUTS-ALPHA 160 KDA SUBUNIT) (G/T MISMATCH BINDING PROTEIN) (GTBP) (GTMBP) (P160) (Homo sapiens)
- gi|1840467|gb|AAB47425.1| (U73737) bacterial MutS homolog [Homo sapiens] (Homo sapiens)
- gi|1082386|pir||A56742_327:716 G/T-binding protein - human (Homo sapiens)
- gi|4504191|ref|NP_000170.1|_395:784 mutS (E. coli) homolog 6 (Homo sapiens)
- gi|1294813|gb|AAC50461.1| (U28946) G/T mismatch binding protein [Homo sapiens] (Homo sapiens)
- gi|6063479|gb|AAB39212.2| (U54777) hMSH6 protein [Homo sapiens] (Homo sapiens)
- gi|123080|sp|P10564|HEXA_STRPN_4:303 DNA MISMATCH REPAIR PROTEIN HEXA (Streptococcus pneumoniae)
- gi|80013|pir||C28667 DNA mismatch repair protein hexA - Streptococcus pneumoniae (Streptococcus pneumoniae)
- gi|153655|gb|AAA88597.1| (M18729) mismatch repair protein [Streptococcus pneumoniae] (Streptococcus pneumoniae)
- gi|1000875|gb|AAB59568.1|_19:354 (L47576) Frameshift mutation results in premature stop [Homo sapiens] (Homo sapiens)
- gi|2497996|sp|Q56239|MUTS_THETH_10:308 DNA MISMATCH REPAIR PROTEIN MUTS (Thermus thermophilus)
- gi|1871501|dbj|BAA09880.1|_10:308 (D63810) MutS [Thermus thermophilus] (Thermus thermophilus)
- gi|2135744|pir||I37550_19:354 mismatch repair protein MSH2 - human (Homo sapiens)
- gi|1079805|gb|AAA82080.1| (U41221) similar to S. cerevisiae Msh2p (Swiss-Prot accession number P25847) and bacterial MutS proteins (Swiss-Prot accession numbers P23909, P10339, and P27345) [Homo sapiens] (Homo sapiens)
- gi|4557761|ref|NP_000242.1|_19:354 mutS homolog 2 (Homo sapiens)
- gi|1171032|sp|P43246|MSH2_HUMAN DNA MISMATCH REPAIR PROTEIN MSH2 (Homo sapiens)
- gi|1082595|pir||A49268 mismatch recognition protein MSH2 - human (Homo sapiens)
- gi|7448106|pir||I64819 DNA mismatch repair protein - human (Homo sapiens)
- gi|432998|gb|AAA61870.1| (U04045) homolog of bacterial MutS proteins [Swiss-Prot accession numbers P23909, P10339, and P27345]; germline mutations are responsible for hereditary nonpolyposis colon cancer (HNPCC) [Homo sapiens] (Homo sapiens)
- gi|433147|gb|AAA18643.1| (U03911) homolog of S. cerevisiae Msh2p [Swiss-Prot accession number P25847] and bacterial MutS proteins [Swiss-Prot accession numbers P23909, P10339, and P27345] [Homo sapiens] (Homo sapiens)
- gi|1000867|gb|AAB59564.1| (L47583) DNA mismatch repair protein [Homo sapiens] (Homo sapiens)
- gi|1000869|gb|AAB59565.1| (L47582) DNA mismatch repair protein [Homo sapiens] (Homo sapiens)
- gi|1000881|gb|AAA76858.1| (L47581) DNA mismatch repair protein [Homo sapiens] (Homo sapiens)
- gi|7448104|pir||I64827_19:354 gene MSH2 protein - human (Homo sapiens)
- gi|1000885|gb|AAB59572.1| (L47580) The deletion results in premature stop [Homo sapiens] (Homo sapiens)
- gi|1000879|gb|AAB59570.1|_19:354 (L47578) The base insertion results in premature stop [Homo sapiens] (Homo sapiens)
- gi|1000883|gb|AAB59571.1|_19:354 (L47579) Insertion mutation results in premature stop [Homo sapiens] (Homo sapiens)
- gi|1000877|gb|AAB59569.1|_19:354 (L47577) mutation causes premature stop [Homo sapiens] (Homo sapiens)
- gi|2506881|sp|P54276|MSH6_MOUSE_394:781 DNA MISMATCH REPAIR PROTEIN MSH6 (MUTS-ALPHA 160 KDA SUBUNIT) (G/T MISMATCH BINDING PROTEIN) (GTBP) (GTMBP) (P160) (Mus musculus)
- gi|1817725|gb|AAC53034.1| (U42190) G/T-mismatch binding protein [Mus musculus] (Mus musculus)
- gi|7448108|pir||S74860_56:385 DNA mismatch repair protein - Synechocystis sp. (strain PCC 6803) (Synechocystis sp.)
- gi|1652903|dbj|BAA17821.1| (D90909) DNA mismatch repair protein [Synechocystis sp.] (Synechocystis sp.)
- gi|7404405|sp|P73769|MUTS_SYNY3_22:351 DNA MISMATCH REPAIR PROTEIN MUTS (Synechocystis PCC6803)
- gi|387849|gb|AAB60711.1|_175:543 (L10319) MutS homologue; major mRNA product contains exon 1a and exon 9b; alternative protein produced from exon 1b and exon 9b [Mus musculus] (Mus musculus)
- gi|110917|pir||A32495_175:543 rep-1 protein, form A - mouse (Mus musculus)
- gi|6320302|ref|NP_010382.1|_299:667 Homolog of the human GTBP protein, forms a complex with Msh2p to repair both single-base and insertion-deletion mispairs, redundant with Msh3p in repair of insertion-deletion mispairs; Msh6p (Saccharomyces cerevisiae)
- gi|3024187|sp|Q03834|MSH6_YEAST MUTS PROTEIN HOMOLOG 6 (Saccharomyces cerevisiae)
- gi|1078208|pir||S51246 probable DNA repair protein YDR097c - yeast (Saccharomyces cerevisiae) (Saccharomyces cerevisiae)
- gi|633631|emb|CAA87671.1| (Z47746) probable DNA repair protein [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|400971|sp|P13705|MSH3_MOUSE_175:543 DNA MISMATCH REPAIR PROTEIN MSH3 (REPAIR-3 PROTEIN) (REP-1) (Mus musculus)
- gi|200706|gb|AAA40052.1| (M80360) Citations 2 and 3 contain revisions to the original sequence in Citation 1. The name of the gene was changed after Citation 1 from Rep-1 to Rep-3 to avoid naming conflict with an unrelated gene.; complete cds of major mRNA [Mus musculus] (Mus musculus)
- gi|2145507|pir||S62790_18:307 mismatch DNA recognition protein mutS - Thermus aquaticus (fragment) (Thermus aquaticus)
- gi|1083296|pir||JC4019_189:578 DNA mismatch repair protein rep-3 - mouse (Mus musculus)
- gi|1588283|prf||2208298A_299:667 MSH6 gene [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|6226648|sp|O04716|MSH6_ARATH_367:747 DNA MISMATCH REPAIR PROTEIN MSH6 (Arabidopsis thaliana)
- gi|7487955|pir||T01508 mismatch repair enzyme T10M13.8 - Arabidopsis thaliana (Arabidopsis thaliana)
- gi|3912921|gb|AAC78699.1| (AF001308) G/T DNA mismatch repair enzyme [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|5763966|emb|CAB53337.1| (AJ245967) mismatch repair protein msh6-1 [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|7268591|emb|CAB80700.1| (AL161493) G/T DNA mismatch repair enzyme [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|6678938|ref|NP_032654.1|_19:354 mutS homolog 2 (E. coli) (Mus musculus)
- gi|1171033|sp|P43247|MSH2_MOUSE DNA MISMATCH REPAIR PROTEIN MSH2 (Mus musculus)
- gi|1083295|pir||S53608 DNA mismatch repair protein MSH2 - mouse (Mus musculus)
- gi|534945|emb|CAA57049.1| (X81143) MSH2 [Mus musculus] (Mus musculus)
- gi|726086|gb|AAA75027.1|_19:354 (U21011) MutS homolog 2 [Mus musculus] (Mus musculus)
- gi|1709122|sp|P54275|MSH2_RAT_19:354 DNA MISMATCH REPAIR PROTEIN MSH2 (Rattus norvegicus)
- gi|7448105|pir||JC6184 mismatch repair protein homolog MSH2 - rat (Rattus norvegicus)
- gi|1103621|emb|CAA63789.1| (X93591) MSH2 protein [Rattus norvegicus] (Rattus norvegicus)
- gi|9294039|dbj|BAB01996.1|_255:604 (AB020746) DNA repair protein MutS [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|118951|sp|P20585|MSH3_HUMAN_220:585 DNA MISMATCH REPAIR PROTEIN MSH3 (DIVERGENT UPSTREAM PROTEIN) (DUP) (MISMATCH REPAIR PROTEIN 1) (MRP1) (Homo sapiens)
- gi|106358|pir||A33507 hypothetical protein DUC-1 - human (Homo sapiens)
- gi|181842|gb|AAB47281.1| (J04810) MSH3 [Homo sapiens] (Homo sapiens)
- gi|4505249|ref|NP_002430.1|_211:576 mutS (E. coli) homolog 3 (Homo sapiens)
- gi|1490521|gb|AAB06045.1| (U61981) hMSH3 [Homo sapiens] (Homo sapiens)
- gi|9106782|gb|AAF84525.1|AE003995_7_39:355 (AE003995) mismatch repair protein [Xylella fastidiosa] (Xylella fastidiosa)
- gi|7379009|emb|CAB83555.1|_4:314 (AL162752) DNA mismatch repair protein [Neisseria meningitidis] (Neisseria meningitidis)
- gi|7492209|pir||T41262_362:716 mutS family DNA mismatch repair protein - fission yeast (Schizosaccharomyces pombe) (Schizosaccharomyces pombe)
- gi|3581916|emb|CAA20855.1| (AL031545) mutS family DNA mismatch repair protein msh6 [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|6644186|gb|AAF20943.1|AF207839_1 (AF207839) mismatch repair protein Msh6 [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|7227419|gb|AAF42468.1|_4:314 (AE002564) DNA mismatch repair protein MutS [Neisseria meningitidis MC58] (Neisseria meningitidis MC58)
- gi|6647605|sp|Q9ZDM9|MUTS_RICPR_13:338 DNA MISMATCH REPAIR PROTEIN MUTS (Rickettsia prowazekii)
- gi|7448114|pir||E71685 DNA mismatch repair protein muts (mutS) RP298 - Rickettsia prowazekii (Rickettsia prowazekii)
- gi|3860859|emb|CAA14759.1| (AJ235271) DNA MISMATCH REPAIR PROTEIN MUTS (mutS) [Rickettsia prowazekii] (Rickettsia prowazekii)
- gi|7387913|sp|O84797|MUTS_CHLTR_4:315 DNA MISMATCH REPAIR PROTEIN MUTS (Chlamydia trachomatis)
- gi|7448116|pir||D71471 probable DNA mismatch repair - Chlamydia trachomatis (serotype D, strain UW3/Cx) (Chlamydia trachomatis)
- gi|3329257|gb|AAC68387.1| (AE001351) DNA Mismatch Repair [Chlamydia trachomatis] (Chlamydia trachomatis)
- gi|6224917|gb|AAF06013.1|AF193018_1_255:604 (AF193018) MutS homolog 7 [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|2104549|gb|AAB57798.1|_374:760 (AF001535) AGAA.3 [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|1079288|pir||S53609_19:353 DNA mismatch repair protein MSH2 - African clawed frog (Xenopus laevis)
- gi|6226653|sp|P74926|MUTS_THEMA_3:299 DNA MISMATCH REPAIR PROTEIN MUTS (Thermotoga maritima)
- gi|7448113|pir||C72219 DNA mismatch repair protein - Thermotoga maritima (strain MSB8) (Thermotoga maritima)
- gi|4982296|gb|AAD36785.1|AE001811_5 (AE001811) DNA mismatch repair protein [Thermotoga maritima] (Thermotoga maritima)
- gi|7190210|gb|AAF39048.1|_4:315 (AE002284) DNA mismatch repair protein MutS [Chlamydia muridarum] (Chlamydia muridarum)
- gi|7387924|sp|Q9Z6W5|MUTS_CHLPN_5:321 DNA MISMATCH REPAIR PROTEIN MUTS (Chlamydophila pneumoniae)
- gi|7448115|pir||G72017 DNA mismatch repair - Chlamydia pneumoniae (strain CWL029) (Chlamydophila pneumoniae)
- gi|4377264|gb|AAD19079.1| (AE001673) DNA Mismatch Repair [Chlamydophila pneumoniae] (Chlamydophila pneumoniae)
- gi|7404403|sp|P49849|MUTS_BACSU_3:300 DNA MISMATCH REPAIR PROTEIN MUTS (Bacillus subtilis)
- gi|7448109|pir||C69663 DNA mismatch repair (recognition) mutS - Bacillus subtilis (Bacillus subtilis)
- gi|2634076|emb|CAB13577.1| (Z99112) mutS [Bacillus subtilis] (Bacillus subtilis)
- gi|1619909|gb|AAB16999.1|_3:299 (U71155) DNA mismatch repair protein [Thermotoga maritima] (Thermotoga maritima)
- gi|7331984|gb|AAF60672.1|_840:1223 (AC024791) contains similarity to Pfam family PF00488 (DNA mismatch repair proteins, mutS family), score=296.7, E=2.9e-85, N=1 [Caenorhabditis elegans] (Caenorhabditis elegans)
- gi|3914075|sp|O51737|MUTS_BORBU_4:312 DNA MISMATCH REPAIR PROTEIN MUTS (Borrelia burgdorferi)
- gi|7448110|pir||D70199 DNA mismatch repair protein (mutS) homolog - Lyme disease spirochete (Borrelia burgdorferi)
- gi|2688751|gb|AAC67157.1| (AE001179) DNA mismatch repair protein (mutS) [Borrelia burgdorferi] (Borrelia burgdorferi)
- gi|8473172|sp|P56883|MUTS_RHIME_21:348 DNA MISMATCH REPAIR PROTEIN MUTS (Sinorhizobium meliloti)
- gi|7189834|gb|AAF38705.1|_5:321 (AE002251) DNA mismatch repair protein MutS [Chlamydophila pneumoniae AR39] (Chlamydophila pneumoniae AR39)
- gi|8979315|dbj|BAA99149.1| (AP002548) DNA mismatch repair [Chlamydophila pneumoniae] (Chlamydophila pneumoniae)
- gi|1002520|gb|AAB19235.1|_1:294 (U27343) MutS [Bacillus subtilis] (Bacillus subtilis)
- gi|1000873|gb|AAB59567.1|_19:338 (L47575) premature stop codon due to mutation [Homo sapiens] (Homo sapiens)
- gi|135075|sp|P26359|SWI4_SCHPO_95:455 MATING-TYPE SWITCHING PROTEIN SWI4 (Schizosaccharomyces pombe)
- gi|101087|pir||S21964 swi4 protein - fission yeast (Schizosaccharomyces pombe) (Schizosaccharomyces pombe)
- gi|7492169|pir||T39178 mating-type switching protein swi4 - fission yeast (Schizosaccharomyces pombe) (Schizosaccharomyces pombe)
- gi|5113|emb|CAA43603.1| (X61306) Swi4 [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|5701972|emb|CAB52164.1| (AL109738) mating-type switching protein swi4 [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|1076927|pir||S22569_5:363 swi4 protein - fission yeast (Schizosaccharomyces pombe) (Schizosaccharomyces pombe)
- gi|4775578|emb|CAB42555.1|_354:699 (AJ238786) MUS2 protein [Zea mays] (Zea mays)
- gi|4775580|emb|CAB42556.1|_47:392 (AJ238787) MUS2 protein [Zea mays] (Zea mays)
- gi|6093453|sp|O83348|MUTS_TREPA_5:319 DNA MISMATCH REPAIR PROTEIN MUTS (Treponema pallidum)
- gi|7448112|pir||C71339 probable DNA mismatch repair protein (mutS) - syphilis spirochete (Treponema pallidum subsp. pallidum)
- gi|3322604|gb|AAC65315.1| (AE001212) DNA mismatch repair protein (mutS) [Treponema pallidum] (Treponema pallidum)
- gi|3319876|emb|CAA07684.1|_94:473 (AJ007791) Msh3 protein [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|6321912|ref|NP_011988.1|_69:414 mutS homolog involved in mitochondrial DNA repair; Msh1p (Saccharomyces cerevisiae)
- gi|730065|sp|P25846|MSH1_YEAST MUTS PROTEIN HOMOLOG 1 (Saccharomyces cerevisiae)
- gi|630277|pir||S48962 MSH1 protein - yeast (Saccharomyces cerevisiae) (Saccharomyces cerevisiae)
- gi|529134|gb|AAB68849.1| (U00059) Yhr120wp [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|172000|gb|AAA34801.1|_69:414 (M84169) homologue of bacterial MutS protein [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|7294307|gb|AAF49656.1|_250:624 (AE003532) CG7003 gene product [Drosophila melanogaster] (Drosophila melanogaster)
- gi|3914079|sp|O66652|MUTS_AQUAE_4:310 DNA MISMATCH REPAIR PROTEIN MUTS (Aquifex aeolicus)
- gi|7448111|pir||H70327 DNA mismatch repair protein MutS - Aquifex aeolicus (Aquifex aeolicus)
- gi|2983001|gb|AAC06613.1| (AE000683) DNA mismatch repair protein MutS [Aquifex aeolicus] (Aquifex aeolicus)
- gi|1174416|sp|P43248|MSH2_DROME_9:351 DNA MISMATCH REPAIR PROTEIN SPELLCHECKER 1 (Drosophila melanogaster)
- gi|675456|gb|AAA62406.1| (U17893) Spellchecker1 [Drosophila melanogaster] (Drosophila melanogaster)
- gi|6166561|sp|O13921|MSH1_SCHPO_50:393 MUTS PROTEIN HOMOLOG 1 (Schizosaccharomyces pombe)
- gi|3914053|sp|O13396|MSH2_NEUCR_14:341 DNA MISMATCH REPAIR PROTEIN MSH2 (Neurospora crassa)
- gi|2606088|gb|AAB84225.1| (AF030634) DNA mismatch repair protein [Neurospora crassa] (Neurospora crassa)
- gi|7287834|gb|AAF44872.1|AE003406_77_24:355 (AE003416) symbol=spel1; synonym=BG:DS01068.9; cDNA=method:''sim4'', score:''1000.0'', desc:''LD33650 LD Drosophila melanogaster embryo pOT2 Drosophila melanogaster cDNA clone LD33650 5prime, mRNA sequence:AA979275''; match=method:''sim4'', score:''100> (Drosophila melanogaster)
- gi|7298155|gb|AAF53392.1|_24:355 (AE003643) spel1 gene product [Drosophila melanogaster] (Drosophila melanogaster)
- gi|6319935|ref|NP_010016.1|_152:495 mutS homolog, forms a complex with Msh2p to repair insertion-deletion mispairs; redundant with Pms3/Msh6p in repair of insertion-deletion mispairs; Msh3p (Saccharomyces cerevisiae)
- gi|127089|sp|P25336|MSH3_YEAST MUTS PROTEIN HOMOLOG 3 (MISMATCH BINDING PROTEIN) (MBP) (Saccharomyces cerevisiae)
- gi|83266|pir||S19508 MSH3 protein - yeast (Saccharomyces cerevisiae) (Saccharomyces cerevisiae)
- gi|4804|emb|CAA46116.1| (X64954) ORF YCR1152 [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|172004|gb|AAA34803.1| (M96250) MSH3 protein [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|1907230|emb|CAA42247.1| (X59720) YCR092c, len:1047 [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|3024198|sp|P70755|MUTS_AQUPY_5:307 DNA MISMATCH REPAIR PROTEIN MUTS (Aquifex pyrophilus)
- gi|1619907|gb|AAB16998.1| (U71154) DNA mismatch repair protein [Aquifex pyrophilus] (Aquifex pyrophilus)
- gi|7269404|emb|CAB81364.1|_94:456 (AL161563) putative DNA mismatch repair protein [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|448278|prf||1916402A_152:494 mismatch repair protein [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|3914062|sp|O65607|MSH3_ARATH_94:456 DNA MISMATCH REPAIR PROTEIN MSH3 (Arabidopsis thaliana)
- gi|7487958|pir||T05793 msh3 protein homolog M7J2.90 - Arabidopsis thaliana (Arabidopsis thaliana)
- gi|2980796|emb|CAA18172.1| (AL022197) putative DNA mismatch repair protein [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|4151103|emb|CAA07342.1|_21:366 (AJ006948) Msh2 [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|7522263|pir||T39832_21:366 dna mismatch repair protein - fission yeast (Schizosaccharomyces pombe) (fragment) (Schizosaccharomyces pombe)
- gi|2894257|emb|CAA17055.1| (AL021839) dna mismatch repair protein [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|4775576|emb|CAB42554.1|_29:348 (AJ238785) MUS1 protein [Zea mays] (Zea mays)
- gi|3914056|sp|O24617|MSH2_ARATH_27:346 DNA MISMATCH REPAIR PROTEIN MSH2 (Arabidopsis thaliana)
- gi|2522362|gb|AAB82649.1| (AF002706) MutS homolog 2 [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|2522364|gb|AAB82650.1| (AF003005) MutS homolog 2 [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|2547236|gb|AAB81282.1| (AF026549) DNA mismatch repair protein MSH2 [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|4139230|gb|AAD04176.1|_27:346 (AF109243) mismatch repair protein [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|6981224|ref|NP_034959.1|_143:373 mutS homolog 3 (E. coli) (Mus musculus)
- gi|110915|pir||B32495 Rep-1 protein B - mouse (Mus musculus)
- gi|200704|gb|AAA40051.1| (M24919) complete cds of class B 1.6 kb mRNA [Mus musculus] (Mus musculus)
- gi|387848|gb|AAB60710.1| (L10319) alternate protein including exons 1b and 9a [Mus musculus] (Mus musculus)
- gi|3886083|gb|AAC78226.1|_17:324 (AF106587) contains similarity to DNA mismatch repair proteins, mutS (Pfam: PF00488, score=376.5, E=2.8e-109, N=1) [Caenorhabditis elegans] (Caenorhabditis elegans)
- gi|9864530|gb|AAG00261.1|_10:389 (AY005798) MSH2 [Trypanosoma cruzi] (Trypanosoma cruzi)
- gi|7522430|pir||T38256_2:232 muts protein homolog 1 - fission yeast (Schizosaccharomyces pombe) (fragment) (Schizosaccharomyces pombe)
- gi|2330782|emb|CAB11169.1| (Z98559) muts protein homolog 1 [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|7547005|gb|AAF63754.1|AF242852_1_64:256 (AF242852) DNA mismatch repair protein [Brassica napus] (Brassica napus)
- gi|6321109|ref|NP_011187.1|_101:317 meiosis specific protein, E.coli MutS protein, localizes to discrete sites on meiotic chromosomes; Msh4p (Saccharomyces cerevisiae)
- gi|1078105|pir||A55201 meiosis-specific protein MSH4 - yeast (Saccharomyces cerevisiae) (Saccharomyces cerevisiae)
- gi|836751|dbj|BAA09235.1| (D50617) MutS protein homolog 4 [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|870825|dbj|BAA08073.1| (D44604) MUST PROTEIN HOMOLOG 4 [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|730066|sp|P40965|MSH4_YEAST_101:317 MUTS PROTEIN HOMOLOG 4 (Saccharomyces cerevisiae)
- gi|563198|gb|AAA65234.1| (U13999) Msh4p [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|4336728|gb|AAD17920.1|_150:361 (AF104243) meiosis-specific MutS homolog [Homo sapiens] (Homo sapiens)
- gi|4505251|ref|NP_002431.1|_150:361 mutS (E. coli) homolog 4 (Homo sapiens)
- gi|3914055|sp|O15457|MSH4_HUMAN MUTS PROTEIN HOMOLOG 4 (Homo sapiens)
- gi|2463653|gb|AAB72039.1| (U89293) MSH4 [Homo sapiens] (Homo sapiens)
- gi|2072992|gb|AAC46142.1|_1:130 (U95756) DNA mismatch repair protein [Synechococcus PCC7942] (Synechococcus PCC7942)
- gi|8515837|gb|AAF76200.1|_188:335 (AF271389) MSH-5 [Caenorhabditis elegans] (Caenorhabditis elegans)
- gi|3914066|sp|Q19272|MSH5_CAEEL_188:335 MUTS PROTEIN HOMOLOG 5 (Caenorhabditis elegans)
- gi|7498739|pir||T20660 hypothetical protein F09E8.3 - Caenorhabditis elegans (Caenorhabditis elegans)
- gi|3875605|emb|CAA98059.1| (Z73896) Similarity to Yeast DNA mismatch repair protein MSH5 (TR:G836681)~cDNA EST yk16g5.5 comes from this gene~cDNA EST yk16g5.3 comes from this gene~cDNA EST yk353a3.5 comes from this gene~cDNA EST yk583f10.3 comes from this gene~cDNA EST yk583f10.> (Caenorhabditis elegans)
- gi|3831701|gb|AAC70065.1|_188:335 (AF070070) MutS homolog [Caenorhabditis elegans] (Caenorhabditis elegans)
- gi|7490460|pir||T37626_49:191 DNA mismatch repair protein homolog - fission yeast (Schizosaccharomyces pombe) (fragment) (Schizosaccharomyces pombe)
- gi|2408012|emb|CAB11774.1| (Z99091) muts protein homolog; DNA mismatch repair protein [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)

              10             20        30            40         50     
              |              |         |             |          |     
   1 MEGMLKGEGPGPLPPL.....LQQYVELRDQYPDYLLLFQVG....DFYECFG.EDAERLARALG
   2 -------KDFSNHTPM.....MQQYLKLKAQHPEILLFYRMG....DFYELFY.DDAKRASQLLD
   3 -------KDFSNHTPM.....MQQYLKLKAQHPEILLFYRMG....DFYELFY.DDAKRASQLLD
   4 --------NFDAHTPM.....MQQYLRLKAQHPEILLFYRMG....DFYELFY.DDAKRASQLLD
   5 --------NFDAHTPM.....MQQYLKLKAQHPEILLFYRMG....DFYELFY.DDAKRASQLLD
   6 -----SEENFQQHTPM.....MQQYLKLKAENPDILLFYRMG....DFYELFY.DDAKKAAALLD
   7 ----SPSESLSHHTPM.....MQQYLRLKAENPDILLFYRMG....DFYELFY.DDAKRASELLD
   8 --------NFDAHTPM.....MQQYLKLKAQHPEILLFYRMG....DFYELFY.DDAKRASQLLD
   9 --------SLSQHTPM.....MQQYWKLKREHPDQLMFYRMG....DFYELFY.EDAKKAAKLLD
  10 --VMLKGEGPGPLPPL.....LQQYVELRDRYPDYLLLFQVG....DFYECFG.EDAERLARALG
  11 ---------LSQHTPM.....MQQYFKLKHQHPDQLMFYRMG....DFYELFY.EDAKKAAKLLD
  12 ---------LSQHTPM.....MQQYFKLKHQHPDQLMFYRMG....DFYELFY.EDAKKAAKLLD
  13 -EGMLKGEGPGPLPPL.....LQQYVELRDQYPDYLLLFQVG....DFYECFG.EDAERLARALG
  14 -----------NVTPM.....MQQYLKIKSEYQDCLLFFRLG....DFYEMFY.EDAKEASRVLE
  15 -TLYVPEDFLNSCTPG.....MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVSELG
  16 -TLYVPEEFLNSCTPG.....MRKWWQLKSQNFDLVIFYKVG....KFYELYH.MDAVIGVSELG
  17 -TLYVPEDFLNSCTPG.....MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVSELG
  18 -TLYVPEDFLNSCTPG.....MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVSELG
  19 -TLYVPEDFLNSCTPG.....MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVSELG
  20 -TLYVPEDFLNSCTPG.....MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVSELG
  21 ----------EKLSPG.....MQQYVDIKKQYPDAFLLFRMG....DFYELFY.EDAVNAAQILE
  22 ---------------F.....VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAREVF
  23 -EGMLKGEGPGPLPPL.....LQQYVELRDRYPDYLLLFQVG....DFYECFG.EDAERLARALG
  24 -EGMLKGEGPGPLPPL.....LQQYVELRDRYPDYLLLFQVG....DFYECFG.EDAERLARALG
  25 ---------------F.....VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAREVF
  26 ---------------F.....VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAREVF
  27 ---------------F.....VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAREVF
  28 ---------------F.....VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAREVF
  29 ---------------F.....VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAREVF
  30 ---------------F.....VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAREVF
  31 -TLYVPEEFLNSCTPG.....MRKWWQLKSQNFDLVIFYKVG....KFYELYH.MDAVIGVSELG
  32 ---------RQKLTPM.....FQHYTEVKEQYQGALLLYRVG....DFFECFF.QDAVIIARELE
  33 ---------RQKLTPM.....FQHYTEVKEQYQGALLLYRVG....DFFECFF.QDAVIIARELE
  34 DCKPFNKRSKSVYTPL.....ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAARELN
  35 DCKPFNKRSKSVYTPL.....ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAARELN
  36 RTLYIPSSAWNKFTPF.....EKQYWEIKSKMWDCIVFFKKG....KFFELYE.KDALLANALFD
  37 DCKPFNKRSKSVYTPL.....ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAARELN
  38 ----------PPLPPL.....LQQYVELRDRYPDYLLLFQVG....DFYECFG.EDAERLARALG
  39 DCKPFNKRSKSVYTPL.....ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAARELN
  40 RTLYIPSSAWNKFTPF.....EKQYWEIKSKMWDCIVFFKKG....KEFELYE.KDALLANALFD
  41 RTLYLPPDFVKKLTGG.....QRQWWEFKAKHMDKVVFFKMG....KFYELFE.MDAHVGAKELD
  42 ---------------F.....VRFFEGMPEKPSTTVRLFDRG....DFYTAHG.EDALLAAREVF
  43 ---------------F.....VRFFEGMPEKPSTTVRLFDRG....DFYTAHG.EDALLAAREVF
  44 ---------------F.....VRFFEGMPEKPSTTVGLFDRG....DFYTAHG.EDALLAAREVF
  45 KTLHIPPDVFKKMSAS.....QKQYWSVKSEYMDIVLFFKVG....KFYELYE.LDAELGHKELD
  46 ---SANKRSKSIYTPL.....ELQYIEMKQQHKDAVLCVECG....YKYRFFG.EDAEIAARELN
  47 ---SANKRSKSIYTPL.....ELQYIEMKQQHKDAVLCVECG....YKYRFFG.EDAEIAARELN
  48 --KPEGGKGMAEHTPL.....MKQYFAAKAEYPDLLLFFRMG....DFYELFH.QDARKAARLLD
  49 ----------SAVSPM.....MQQYLGIKAQHTDKLVFYRMG....DFYEMFF.DDAVEAAKLLD
  50 RTLYIPPSAWATFKPF.....EKQFWKIKKDLMDTVVFFQKG....KFYELYE.NDAAIGHQVFS
  51 ----------SAVSPM.....MQQYLGIKAQHTDKLVFYRMG....DFYEMFF.DDAVEAAKLLD
  52 -----QKYNYNVATKM.....MQQYLDIKFAHLDCLLLFRMG....DFYELFY.EDAILASNILG
  53 -----------KLTPM.....MQQWHQCKEQAGDCLLLFRLG....EFYEAFF.DDALILAQNLD
  54 KTLHIPPDVFKKMSAS.....QKQYWSVKSEYMDIVLFFKVG....KFYELYE.LDAELGHKELD
  55 --LYLPPDFVKKLTGGqv8gnLRQWWEFKAKHMDKVVFFKMG....KFYELFE.MDAHVGAKELD
  56 ---------------F.....LHFYQSMPEKPDTTVRVFDRN....DYYTVHG.GDALFAAKEVF
  57 ------------VTPL.....MEQYLRIKEQYKDSILLFRLG....DFYEAFF.EDAKIVSKVLN
  58 -----------KLTPM.....MQQWHQCKEQAGDCLLLFRLG....EFYEAFF.DDALVLAQNLD
  59 -----------KPTPM.....MEQWHQCKEKAGDSVLLFRMG....DFYEAFY.DDAVLLSQHLE
  60 -----------GYTPM.....IQQYLKIKAEHQDAFLFFRLG....DFYEMFF.EDAKKASQELE
  61 ------------VTPL.....MEQYLRIKEQYKDSILLFRLG....DFYEAFF.EDAKIVSKVLN
  62 KTLWVPPDFHQKQTPG.....HRQWWTMKSQHFDTILLFKVG....KFYETYH.MDAVEVVRALN
  63 -----------NVTPM.....IRQYLDIKKKYKDAVLFFRVG....SFYEMFF.DDAIEVSKLLN
  64 ----ASEESRSTATPM.....MEQFIEIKANNPDSLLFYRMG....DFYELFF.QDAVEASRALG
  65 -----------KPTPM.....MEQWHQCKEKAGDSVLLFRMG....DFYEAFY.DDAVLLSQHLE
  66 ---------------M.....IQQYLKIKAEHQDAFLFFRLG....DFYEMFF.EDAKKASQELE
  67 ---------------F.....VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAREVF
  68 ----KPTKQKSVFTPL.....EQQYLELKKNYQETILAIEVG....YKFRFFG.KDAKIASEVLG
  69 ------TKQKSVFTPL.....EQQYLELKKNYQETILAIEVG....YKFRFFG.KDAKIASEVLG
  70 -TLFIPPDALRKMSTS.....QKQYWNIKCKYMDVVLFFKVG....KFYELYE.LDAEIGQKELD
  71 -TLFIPPDALRKMSTS.....QKQYWNIKCKYMDVVLFFKVG....KFYELYE.LDAEIGQKELD
  72 ----------ASDTPL.....MRQYHAIRAQHPDAVLFFRLG....DFYEMFD.SDALHVSTLLG
  73 --YVPETSSSRKYTPL.....EQQVVELKSKYPDVVLMVEVG....YRYRFFG.EDAEIAARVLG
  74 --LSSTEPSKASLPPS.....LQYVRDLMDLYKDHVVLTQMG....SFYELYF.EQAIRYAPELN
  75 --LSSTEPSKASLPPS.....LQYVRDLMDLYKDHVVLTQMG....SFYELYF.EQAIRYAPELN
  76 -TLHVPEKFLNGLSPG.....VRQWWVLKSDNYDCVLFFKVG....KFYELYH.MDADVGVNELG
  77 --------SEKELTPM.....LSQYHYFKNQYPDCLLLFRLG....DFYELFY.EDAYIGSKELG
  78 ----YPEYGHKCASNF.....IKFHAKLGEKPATTVRFFDHT....DRYTVHGsDDCELVAKIVY
  79 --DFIRPKEKVTLPPL.....LKEVSFQQKKFADCVLLTKVG....NFYEMYF.EQAEKIGPLLN
  80 --------------GF.....IRFYKSLPQLGEEAIRIFDRG....DWYTAHG.DDATFIARTVY
  81 ---------------F.....IKFHAKLGEKPATTVRFFDHT....DRYTVHGsDDCELVAKIVY
  82 ---------------F.....IKFHAKLGEKPATTVRFFDHT....DRYTVHGsDDCELVAKIVY
  83 ---KARKSPTAKLTPL.....DKQVKDLKMHHRDKVLVIRVG....YKYKCFA.EDAVTVSRILH
  84 ---------EKELTPM.....LAQYHQFKSMYPDCLLLFRLG....DFYELFY.EDAVVGSKELG
  85 --YVPETSSSRKYTPL.....EQQVVELKSKYPDVVLMVEVG....YRYRFFG.EDAEIAARVLG
  86 ---KARKSPTAKLTPL.....DKQVKDLKMHHRDKVLVIRVG....YKY-CFA.EDAVTVSRILH
  87 --YVPETSSSRKYTPL.....EQQVVELKSKYPDVVLMVEVG....YRYRFFG.EDAEIAARVLG
  88 ----------------.....---FYEKMPKDTNTVRVFDRG....EFYVAIG.EDASFVAQNAY
  89 ----------------.....---FYEKMPKDTNTVRVFDRG....EFYVAIG.EDASFVAQNAY
  90 ----------------.....---FFKKLPQDPRAVRLFDRR....DYYTAHG.ENATFIARTYY
  91 ----------------.....---FYKTLPNDTRAVRFFDRK....DYYTAHG.ENSVFIAKTYY
  92 ----------------.....---FYKTLPNDTRAVRFFDRK....DYYTAHG.ENSVFIAKTYY
  93 DCKPFNKRSKSVYTPL.....ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAARELN
  94 ----------------.....------LKSKSPNTIAIFSRG....EYFSVYG.DDATFVATNIF
  95 ----------------.....LQAFTAVGGDDKACVRLFSRGgstpGCYVLGS.WAGFIAREYIR
  96 ----------------.....---------------------....-------.-----------
  97 ----------IKYTPL.....EQQVVELKRKHPDVILMVEVG....YRYRFFG.EDAEIAARVLG
  98 ----------------.....---------------------....-------.-----------
  99 ----------------.....---------------------....-------.-----------
 100 ----------------.....---------------------....-------.-----------
 101 ----------------.....---------------------....-------.-----------
 102 ----------------.....---------------------....----CFF.QDAIVVARELE
 103 ----------------.....---------------------....-------.-----------
 104 ----------------.....---------------------....-------.-----------
 105 ----------------.....---------------------....-------.-----------
 106 -LDFIRPKEKVTLPPL.....LKEVSFQQKKFADCVLLTKVG....NFYEMYF.EQAEKIGPLLN


              60              70        80            90       100     
              |               |         |             |         |     
   1 L.....VLTHK.....TSK.DFTTPMAGIPLRAFEAYAER..LL..KMGFRLAVADQVEPA...E
   2 I.....SLTKR.....GASaGEPIPMAGIPHHAVENYLAK..LV..NQGESVAICEQIGDP...A
   3 I.....SLTKR.....GASaGEPIPMAGIPHHAVENYLAK..LV..NQGESVAICEQIGDP...A
   4 I.....SLTKR.....GASaGEPIPMAGIPYHAVENYLAK..LV..NQGESVAICEQIGDP...A
   5 I.....SLTKR.....GASaGEPIPMAGIPYHAVENYLAK..LV..NQGESVAICEQIGDP...A
   6 I.....SLTKR.....GQSaGQPIPMAGMPYHAVEGYLAK..LV..QLGESVAICEQIGDP...T
   7 I.....SLTKR.....GASaGEPIPMAGVPFHAVEGYLAK..LV..QMGESVAICEQIGDP...A
   8 I.....SLTKR.....SASaGEPIPMAGIPYHAVENYLAK..LV..NQGESVAICEQIGDP...A
   9 I.....TLTAR.....GQSaGKSIPMAGIPFHSVEGYLAK..LV..KLGESVAICEQIGDP...A
  10 L.....VLTHK.....TSK.DFTTPMAGIPIRAFDAYAER..LL..RMGFGLAVADQVEPA...E
  11 I.....TLTAR.....GQSgGKAIPMAGIPFHSAEGYLAK..LV..KLGESVAICEQIGDP...A
  12 I.....TLTAR.....GQSgGKAIPMAGIPFHSAEGYLAK..LV..KLGESVAICEQIGDP...A
  13 L.....VLTHK.....TSK.DFTTPMAGIPLRAFEAYAER..LL..KMGFRLAVADQVEPA...E
  14 I.....TLTKR.....DAKkENPIPMCGVPYHSADSYIDT..LV..NNGYKVAICEQMEDP...K
  15 L.....VFMK-.....---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQTETP...E
  16 L.....IFMK-.....---.-GNWAHSGFPEIAFGRFSDS..LV..QKGYKVARVEQTETP...E
  17 L.....VFMK-.....---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQTETP...E
  18 L.....VFMK-.....---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQTETP...E
  19 L.....VFMK-.....---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQTETP...E
  20 L.....VFMK-.....---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQTETP...E
  21 I.....SLTSR.....NKNaDNPIPMAGVPYHSAQQYIDV..LI..EQGYKVAIAEQMEDP...K
  22 K.....TQGVIkymg.PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNRAGN...K
  23 L.....VLTHK.....TSK.DFTTPMAGIPIRAFDAYAER..LL..KMGFRLAVADQVEPA...E
  24 L.....VLTHK.....TSK.DFTTPMAGIPIRAFDAYAER..LL..KMGFRLAVADQVEPA...E
  25 K.....TQGVIkymg.PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNRAGN...K
  26 K.....TQGVIkymg.PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNRAGN...K
  27 K.....TQGVIkymg.PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNRAGN...K
  28 K.....TQGVIkymg.PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNRAGN...K
  29 K.....TQGVIkymg.PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNRAGN...K
  30 K.....TQGVIkymg.PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNRAGN...K
  31 L.....IFMK-.....---.-GNWAHSGFPEIAFGRFSDS..LV..QKGYKVARVEQTETP...E
  32 L.....ILTSKeg...GKE.IGRVAMTGVPHHALDRYARQ..LV..EKGYAVAICDQVEDA...A
  33 L.....ILTSKeg...GKE.IGRVAMTGVPHHALDRYARQ..LV..EKGYAVAICDQVEDA...A
  34 I.....YCHL-.....---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQTETA...A
  35 I.....YCHL-.....---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQTETA...A
  36 L.....KIAG-.....-GG.RANMQLAGIPEMSFEYWAAQ..FI..QMGYKVAKVDQRESM...L
  37 I.....YCHL-.....---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQTETA...A
  38 L.....VLTHK.....TSK.DFTTPMAGIPIRAFDAYAER..LL..KMGFRLAVADQVEPA...E
  39 I.....YCHL-.....---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQTETA...A
  40 L.....KIAG-.....-GG.RANMQLAGIPEMSFEYWAAQ..FI..QMGYKVAKVDQRESM...L
  41 I.....QYMK-.....---.-GEQPHCGFPEKNFSVNIEK..LV..RKGYRVLVVEQTETP...D
  42 K.....TQGVIkymg.PAG.SKTLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNKAGN...K
  43 K.....TQGVIkymg.PAG.SKTLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNKAGN...K
  44 K.....TQGVIkymg.PAG.AKTLQTVVLSKMNFESFVKDl.LL..VRHYRVEVYKNKAGN...K
  45 W.....KMTM-.....-SG.VGKCRQVGISESGIDEAVQK..LL..ARGYKVGRIEQLETS...D
  46 I.....YCHL-.....---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQTETA...A
  47 I.....YCHL-.....---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQTETA...A
  48 I.....TLTQR.....GSSgGAPIPMAGVPVHAYEGYLAR..LI..ALGESVAICEQIGDP...G
  49 I.....TLTTR.....GQVdGEPVKMAGVPFHAAEQYLAR..LV..KLGKSVAICEQVGEV...G
  50 L.....KLTDR.....---.-VNMKMVGIPEASFDYWASQ..FI..AKGYRIARVDQLETA...L
  51 I.....TLTTR.....GQVdGEPVKMAGVPFHAAEQYLAR..LV..KLGKSVAICEQVGEV...G
  52 I.....ALTKR.....GKNcEEEIPMCGVPYHALEHYLTK..LI..EENYKVAICDQLETP...E
  53 I.....TLTQR.....---.-QNVPMSGIPATCLDGYVDR..LV..SRGFKVAIAEQADNT...E
  54 W.....KMTM-.....-SG.VGKCRQVGISESGIDEAVQK..LL..ARGYKVGRIEQLETS...D
  55 I.....QYMK-.....---.-GEQPHCGFPEKNFSVNIEK..LV..RKGYRVLVVEQTETP...D
  56 K.....TNGVIkyl..GSG.NKKLESVVLSKMNFESVVKDl.LL..VRQYRVEVYKNKSGG...K
  57 I.....VLTRR.....---.-QDAPMAGIPYHALNTYLKK..LV..EAGYKVAICDQMEEP...S
  58 I.....TLTQR.....---.-QNIPMSGIPAAYLDGYVDR..LV..SRGFKIAIAEQADNS...E
  59 L.....TLTQR.....---.-QGIPMSGIPVSTVDTYVDR..LI..GKGFKVAVAEQFGEP...A
  60 I.....TLTSR.....DGGaAEKIPMCGVPYHSASAYIEQ..LI..KKGYKVAICEQTEDP...K
  61 I.....VLTRR.....---.-QDAPMAGIPYHALNTYLKK..LV..EAGYKVAICDQMEEP...S
  62 I.....AFMR-.....---.-GSYAHAGFPEHAASKFADQ..LM..NHGYKVARIEQTETP...Q
  63 L.....TLTKR.....---.-ENVPMCGVPYHTSKEYIRK..LI..LFDKKVAICEQASN-...S
  64 I.....TLTKR.....GQHmGQEIPMCGVPVHAADDYLQK..LI..ASGYRVAVCEQVEDP...A
  65 L.....TLTQR.....---.-QGIPMSGIPVSTVDTYVDR..LI..GKGFKVAVAEQFGEP...A
  66 I.....TLTSR.....DGGaAEKIPMCGVPYHSASAYIEQ..LI..KKGYKVAICEQTEDP...K
  67 K.....TQGVIkymg.PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNRAGN...K
  68 I.....SCYF-.....---.EHNFLNASVPSYRIDYHLER..LI..NFGLKVAVVRQTETA...A
  69 I.....SCYF-.....---.EHNFLNASVPSYRIDYHLER..LI..NFGLKVAVVRQTETA...A
  70 W.....KMTV-.....-SG.VGKCRQVGISESGIDDAVDK..LI..ARGYKVGRIEQMESA...N
  71 W.....KMTV-.....-SG.VGKCRQVGISESGIDDAVDK..LI..ARGYKVGRIEQMESA...N
  72 L.....TLTKR.....---.-NGTPMCGVPVHTARTHIAR..LL..KHGKKVALCEQVSHP...V
  73 I.....YAHM-.....---.DHNFMTASVPTFRLNFHVRR..LV..NAGYKIGVVKQTETA...A
  74 I.....SLTNR.....AYS.HGKVPFAGFPVHQLSRHLKM..LVn.NCGYSVTIAEQFKKK...D
  75 I.....SLTNR.....AYS.HGKVPFAGFPVHQLSRHLKM..LVn.NCGYSVTIAEQFKKK...D
  76 F.....TYMR-.....---.-GEFAHSGFPEISFDKMSTI..LV..DRGFKVARVEQTETP...D
  77 L.....VLTSRpa...GKG.KERIPMCGVPYHSANSYIAK..LV..NKGYKVAICEQVEDP...S
  78 K.....STAFIgallpDDK.KETLQFVSMSKGNFELAVREl.LL..VRNYRVEVY------...-
  79 L.....RVSKK.....KTS.KSDVSMAGFPFFKLDRYLKI..LVe.DLKKCVALSEEVIRPvddL
  80 K.....TTSVIrqlg.RSD.HTGLPSVTMTVTVFRQFLREa.LF..KLGKRIEIW------...A
  81 K.....STAFIgallpDDK.KETLQFVSMSKGNFELAVREl.LL..VRNYRVEVY------...-
  82 K.....STAFIgallpDDK.KETLQFVSMSKGNFELAVREl.LL..VRNYRVEVY------...-
  83 I.....KLVPGk10pqDCN.HRQFAYCSFPDVRLNVHLER..LV..HHNLKVAVVEQAETS...A
  84 L.....VLTSRpa...GKG.RERIPMCGVPYHSANNYIAK..LV..NKGYKVAICEQVEDP...S
  85 I.....YAHM-.....---.DHNFMTA-------------..--..--GYKIGVVKQTETA...A
  86 I.....KLVPGk10pqDCN.HRQFAYCSFPDVRLNVHLER..LV..HHNLKVAVVEQAETS...A
  87 I.....YAHM-.....---.DHNFMTA-------------..--..--RYKIGVVKQTETA...A
  88 H.....TTSVLk....HHN.VSNTSYCNLSPSLFIKFAEDv.LS..NLAKRVEIW------...G
  89 H.....TTSVLk....HHN.VSNTSYCNLSPSLFIKFAEDv.LS..NLAKRVEIW------...G
  90 H.....TMSALrql..GSS.SDGILSASVSKAMFETIARNilLE..RTDCTLELYEGSGS-...-
  91 H.....TTTALrql..GSG.SNALSSVSISRNMFETIARD..LLleRNDHTVELYEGSGS-...-
  92 H.....TTTALrql..GSG.SNALSSVSISRNMFETIARD..LLleRNDHTVELYEGSGS-...-
  93 I.....YCHL-.....---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQTETA...A
  94 Ksd6vkTFTLS.....TDN.SQQMKYISVNRGQYEKVVREt.IV..LLRCSVELY------...-
  95 S.....TAVL-.....-KN.WGGVDVVVVNDSIAKEVIRDc.LL..RRGASVEYYERPPGG...G
  96 -.....-----.....---.--------------------..--..---------------...-
  97 I.....YAHM-.....---.DHSFMTASVPTFRLNVHVRG..LV..NAGYKVGVVKQTETA...A
  98 -.....-----.....---.--------------------..--..---------------...-
  99 -.....-----.....---.--------------------..--..---------------...-
 100 -.....-----.....---.--------------------..--..---------------...-
 101 -.....-----.....---.--------------------..--..---------------...-
 102 L.....VLTSKea...GKE.VGRVPMAGIPYHALDRYASQ..LV..EKGYAIAICDQVETA...A
 103 -.....-----.....---.--------------------..--..---------------...-
 104 -.....-----.....---.--------------------..--..---------------...-
 105 -.....-----.....---.--------------------..--..---------------...-
 106 L.....RVSKK.....KTS.KSDVSMAGFPFFKLDRYLKI..LVe.DLKKCVALSEEVIRPvddL


                110       120              130             140       15
                 |         |                |               |         
   1 EAE.....GLVRREVTQLLTPGTLLQ..ESLLP.....RE.ANYLAAIAT.....GDGWGLAFLD
   2 TSK.....GPVERKVVRIVTPGTISD..EALLQe....RQ.DNLLAAIWQd....GKGYGYATLD
   3 TSK.....GPVERKVVRIVTPGTISD..EALLQe....RQ.DNLLAAIWQd....GKGYGYATLD
   4 TSK.....GPVERKVVRIVTPGTISD..EALLQe....RQ.DNLLAAIWQd....SKGFGYATLD
   5 TSK.....GPVERKVVRIVTPGTISD..EALLQe....RQ.DNLLAAIWQd....SKGFGYATLD
   6 TSK.....GPVERQIVRIVTPGTVSD..EALLPe....RQ.DNLIAAVYQe....KEKFGLATLD
   7 TSK.....GPVERKVVRIVTPGTVTD..EALLSe....RV.DNLIAAIYHh....NGRFGYATMD
   8 TSK.....GPVERKVVRIVTPGTISD..EALLQe....RQ.DNLLAAIWQd....SKGFAYATLD
   9 TTK.....GPVERQVVRIITPGTVSD..EALLDe....RR.DNLLAAVVGd....ERLFGLAILD
  10 EAE.....GLVRREVTQLLTPGTLTQ..EALLP.....RE.ANYLAAIAT.....GDGWGLAFLD
  11 TSK.....GPVERQVVRIITPGTVSD..EALLDe....RR.DNLLAAILGd....ERLFGLAVLD
  12 TSK.....GPVERQVVRIITPGTVSD..EALLDe....RR.DNLLAAILGd....ERLFGLAVLD
  13 EAE.....GLVRREVTQLLTPGTLLQ..ESLLP.....RE.ANYLAAIAT.....GDGWGLAFLD
  14 QTK.....GMVRREVVRIVTPGTVMEq.GGVDD.....KQ.NNYILSFVMn....QPEIALSYCD
  15 MMEa13ydRVVRREICRIITKGTQTY..SVLEGdpse.NY.SKYLLSLKEke8ghTRAYGVCFVD
  16 MMEa13fdRVVRREICRIITKGTQTY..SVLDGdpse.NY.SRYLLSLKEke8ghTRVYGVCFVD
  17 MMEa13ydRVVRREICRIITKGTQTY..SVLEGdpse.NY.SKYLLSLKEke8ghTRAYGVCFVD
  18 MMEa13ydRVVRREICRIITKGTQTY..SVLEGdpse.NY.SKYLLSLKEke8ghTRAYGVCFVD
  19 MMEa13ydRVVRREICRIITKGTQTY..SVLEGdpse.NY.SKYLLSLKEke8ghTRAYGVCFVD
  20 MMEa13ydRVVRREICRIITKGTQTY..SVLEGdpse.NY.SKYLLSLKEke8ghTRAYGVCFVD
  21 QAV.....GVVKREVVQVITPGTVVD..SSKPD.....SQ.NNFLVSIDRe....GNQFGLAYMD
  22 ASK.....E-NDWYLAYKASPGNLSQf.EDILF.....GN.NDMSASIGVv10dgQRQVGVGYVD
  23 EAE.....GLVRREVTQLLTPGTLTQ..EALLP.....RE.ANYLAAIAT.....GDGWGLAFLD
  24 EAE.....GLVRREVTQLLTPGTLTQ..EALLP.....RE.ANYLAAIAT.....GDGWGLAFLD
  25 ASK.....E-NDWYLAYKASPGNLSQf.EDILF.....GN.NDMSASIGVv10dgQRQVGVGYVD
  26 ASK.....E-NDWYLAYKASPGNLSQf.EDILF.....GN.NDMSASIGVv10dgQRQVGVGYVD
  27 ASK.....E-NDWYLAYKASPGNLSQf.EDILF.....GN.NDMSASIGVv10dgQRQVGVGYVD
  28 ASK.....E-NDWYLAYKASPGNLSQf.EDILF.....GN.NDMSASIGVv10dgQRQVGVGYVD
  29 ASK.....E-NDWYLAYKASPGNLSQf.EDILF.....GN.NDMSASIGVv10dgQRQVGVGYVD
  30 ASK.....E-NDWYLAYKASPGNLSQf.EDILF.....GN.NDMSASIGVv10dgQRQVGVGYVD
  31 MMEa13fdRVVRREICRIITKGTQTY..SVLDGdpse.NY.SRYLLSLKEke8ghTRVYGVCFVD
  32 EAQaek..RMVERQVTKLLTPGTLTD..DSMLPa....KR.NNFLAAIAMv....EDKWGLAHAD
  33 EAQaek..RMVERQVTKLLTPGTLTD..DSMLPa....KR.NNFLAAIAMv....EDKWGLAHAD
  34 LKAig6ksSVFSRKLTALYTKSTLIG..EDVNPl16tdTS.TNYLLCIYEe11kgNLSVGVVGVQ
  35 LKAig6ksSVFSRKLTALYTKSTLIG..EDVNPl16tdTS.TNYLLCIYEe11kgNLSVGVVGVQ
  36 AKEmr6skGIVKRELQCILTSGTLTD..GDMLH.....SDlATFCLAIREe21lnTKIFGAAFID
  37 LKAig6ksSVFSRKLTALYTKSTLIG..EDVNPl16tdTS.TNYLLCIYEe11kgNLSVGVVGVQ
  38 EAE.....GLVRREVTQLLTPGTLTQ..EALLP.....RE.ANYLAAIAT.....GDGWGLAFLD
  39 LKAig6ksSVFSRKLTALYTKSTLIG..EDVNPl16tdTS.TNYLLCIYEe11kgNLSVGVVGVQ
  40 AKEmr6skGIVKRELQCILTSGTLTD..GDMLH.....SDlATFCLAIREe21lnTKIFGAAFID
  41 QLEq10kdKVVKREVCAVVTKGTLTD..GEMLLtn...PD.ASYLMALTEg10taEHNFGVCLVD
  42 ASK.....E-NEWYLAFKASPGNLSQf.EDILF.....GN.NDMSASVGVm10dgQRHVGVGYVD
  43 ASK.....E-NEWYLAFKASPGNLSQf.EDILF.....GN.NDMSASVGVm10dgQRHVGVGYVD
  44 ASK.....E-NDWYLAYKASPGNLSQf.EDILF.....GN.NDMATSIGIm10dgQRQVGVGDVD
  45 QAKarganTIIPRKLVQVLTPSTASE..GNIGP.....DA.V-HLLAIKEik8kcSTVYGFAFVD
  46 LKAig6rsSLFSRKLTALYTKSTLIG..EDVNPl16tdTS.TSYLLCISEn11kgNIFIGIVGVQ
  47 LKAig6rsSLFSRKLTALYTKSTLIG..EDVNPl16tdTS.TSYLLCISEn11kgNIFIGIVGVQ
  48 LAK.....GLVERKVVRIVTPGTITD..EVLLEe....RR.DTLLMALSRs....KNCYGLAWAD
  49 AGK.....GPVERKVVRIVTPGTLTD..SALLEd....KE.TNRIVAVSPd....KKYIGLAWAS
  50 GKEi11eeKVVQRGLTQVLTSGTLVD..EAMLT.....SDlSTYCMAIKEsl7neEPSFGICFID
  51 AGK.....GPVERKVVRIVTPGTLTD..SALLEd....KE.TNRIVAVSPd....KKYIGLAWAS
  52 EAKkr6ykAVVTRDVTRIITPGTIIE..ENLISv....TE.PNYLTSLVIpkn..KKTASICCVD
  53 GSK.....GLVPRTINRLITPGALLS..SSLLPe....KA.NNYVLAINQv....GSLYGLSCLD
  54 QAKarganTIIPRKLVQVLTPSTASE..GNIGP.....DA.V-HLLAIKEik8kcSTVYGFAFVD
  55 QLEq10kdKVVKREVCAVVTKGTLTD..GEMLLtn...PD.ASYLMALTEg10taEHNFGVCLVD
  56 YSK.....E-NDWQLAFKASPGNLTQf.EEILF.....GN.NDMSTAVGVv10egQRLVGVGYVD
  57 KSK.....KLIRREVTRVVTPGSIVE..DEFLS.....ET.NNYMAVVSEe....KGRYCTVFCD
  58 GGK.....GLVPRTINRLITPGALLS..SSLLPe....KA.NNYIIAISQv....GSLYGLSCLD
  59 KEKeskkiGPMARDIQRFVTPGTLLS..STLLQe....KF.NNYIVAINRi....GSLFGFACLD
  60 AAK.....GVVKREVVQLITPGTVMDg.KGIHE.....SE.NNFIASVSAc....SNGYGLALSD
  61 KSK.....KLIRREVTRVVTPGSIVE..DEFLS.....ET.NNYMAVVSEe....KGRYCTVFCD
  62 MLEe10keKVVRREVCRVTSNGTRTY..GVLDGv11ldPT.AKHLLAIKEfh7tgKSSYGVCMID
  63 TSG.....GPLEREVVEVITPGVIID..EDFLN.....DDiNNYLVAISDy....KDYYSFSYID
  64 EAKkrgskSVVRRDVVRLVTPGTITE..DKLLSp....SE.SNYLMALARirsgsEPAYALAWID
  65 KEKeskkiGPMARDIQRFVTPGTLLS..STLLQe....KF.NNYIVAINRi....GSLFGFACLD
  66 AAK.....GVVKREVVQLITPGTVMDg.KGIHE.....SE.NNFIASVSAc....SNGYGLALSD
  67 ASK.....E-NDWYLAYKASPGNLSQf.EDILF.....GN.NDMSASIGVv10dgQRQVGVGYVD
  68 LKSts6rnTLFDRRVARVLTKGTTLD..DSFFRfe9tlQA.SQFILCVADn10sgRVQVGLIAIQ
  69 LKSts6rnTLFDRRVARVLTKGTTLD..DSFFRfe9tlQA.SQFILCVADn10sgRVQVGLIAIQ
  70 QAKargvhSVIERKLVHVSTPSTAVDn.---IG.....TD.AVHLLALKEvt7sgFQVFGFAFLD
  71 QAKargvhSVIERKLVHVSTPSTAVDn.---IG.....TD.AVHLLALKEvt7sgFQVFGFAFLD
  72 -PG.....ELTQRKVIEIISPGTAVE..DDFLSq....GF.SQYLATVCAs....DATVAFSYLE
  73 IKShg6rtGPFFRGLSALYTKATLEAa.EDISGgc9fgSQ.SNFLVCVVDe16sfDVRVGVVGVE
  74 VADnea..NKFYRRVTRIVTPGTFID..EAFENl....RE.NTYLLNIEFp11dtSLKVGICWCD
  75 VADnea..NKFYRRVTRIVTPGTFID..EAFENl....RE.NTYLLNIEFp11dtSLKVGICWCD
  76 MMTe12fdKVVAREICQITNRGTQVF..GSQCKigpn.HQ.PNYMLAIVEkdegtCSRYGVCFID
  77 KAK.....GIVKREVVRVITPGTFFE..-----.....RD.TGGLASLYKk....GNHYYVGYLN
  78 -VK.....NSSDWEIEYRGSPGNLLQf.EDILF.....SN.KEVLVGNSIi11ggQRRVGVASVE
  79 SSK.....NMYIRSVTRVITPGTLID..ENFMNp....YE.SNYILTVVFd22faDCKIGLSWLD
  80 SPS.....GRMNWKVVKQASPGNLQDv.EDELGgqf..EG.APVILAVKIsa6seARTVGVCFAD
  81 -VK.....NSSDWEIEYRGSPGNLLQf.EDILF.....SN.KEVLVGNSIi11ggQRRVGVASVE
  82 -VK.....NSSDWEIEYRGSPGNLLQf.EDILF.....SN.KEVLVGNSIi11ggQRRVGVASVE
  83 IKKhd8ksSVFERKISNVFTKATFGV..NSTFVlr7ilGD.TNSIWALSRdv6gkVAKYSLISVN
  84 KAK.....GIVKRDVIRVITPGTFFE..-----.....RE.TGGLCSLYRk....GKSYLVSYLN
  85 IKShg6rtGPFFRGLSALYTKATLEAa.EDISGgc9fgSQ.SNFLVCVVDe16sfDVRVGVVGVE
  86 IKKhd8ksSVFERKISNVFTKATFGV..NSTFVlr7ilGD.TNSIWALSRdv6gkVAKYSLISVN
  87 IKShg6rtGPFFRGLSALYTKATLEAa.EDISGgc9fgSQ.SNFLVCVVDe16sfDVRVGVVGVE
  88 ANS.....AKTGFELLKQASPGNMQMl.EDLLVs13dsSV.SSVLLAVTTrvkqdQRIIGVAFID
  89 ANS.....AKTGFELLKQASPGNMQMl.EDLLVs13dsSV.SSVLLAVTTrvkqdQRIIGVAFID
  90 ---.....---NWRLTKSGTPGNIGSf.EDILFanndmED.SPVIVALFPacresQLYVGLSFLD
  91 ---.....---NWRLVKTGSPGNIGSf.EDVLFannemQD.TPVVVSIFPsfhdgRCVIGMAYVD
  92 ---.....---NWRLVKTGSPGNIGSf.EDVLFannemQD.TPVVVSIFPsfhdgRCVIGMAYVD
  93 LKAig6ksSVFSRKLTALYTKSTLIG..EDVNPl16tdTS.TNYLLCIYEe11kgNLSVGVVGVQ
  94 -SS.....EQGEWKMTKRGSPGNTVDfeQEIGV.....SD.QAPILAIYIhpgddDNRVTLCAWD
  95 ---.....---TYACVQRGSPGNITDf.EATLF.....SF.EEAEIQLMAt24gqGIRVGFAALN
  96 ---.....------VTRVITPGTLID..ENFMNp....YE.SNYILTVVFd22faDCKIGLSWLD
  97 IKShg6raGPFFRGLSGLYTKATLEAa.EDISGgc9fgGQ.SNFLVCVVDe17sfDVRVGVVGVE
  98 ---.....------------------..-----.....SI.DCVLCCIYEvprdiSTRIGLCIIN
  99 ---.....------------------..-----.....SI.DCVLCCIYEvprdiSTRIGLCIIN
 100 ---.....------------------..---SA.....HS.PSVIVAVVEgrglaRGEIGMASID
 101 ---.....------------------..---SA.....HS.PSVIVAVVEgrglaRGEIGMASID
 102 QAQg....PLVRREITRIITPGTILE..EGMLQa....RR.NNFLAAVVIa....GEHWGLAYAD
 103 ---.....------------------..-----.....--.---------.....----------
 104 ---.....------------------..-----.....--.---------.....----------
 105 ---.....------------------..-----.....--.---------.....----------
 106 SSK.....NMYIRSVTRVITPGTLID..ENFMNp....YE.SNYILTVVF.....----------


      0       160           170       180            190       200     
     |         |             |         |              |         |     
   1 VSTGEFKGTVLKS....KSALYDELFRHRPAEVLL.....APELLENGAFLDEFRKRFPVMLSEA
   2 ISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMALIEGRRGLRRRPLWEFE
   3 ISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMALIEGRRGLRRRPLWEFE
   4 ISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMSLIEGRRGLRRRPLWEFE
   5 ISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMSLIEGRRGLRRRPLWEFE
   6 MTSGRFQLCEPAD....KETLRAELQRIAPVELLY.....CEEFNEMAAIEHCKGLRRRPIWEFE
   7 ITSGRFQLSEPQT....EEEMAAELQRTSPRELLF.....PEDFSPVHLMASRQGNRRRPIWEFE
   8 ISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMSLIEGRRGLRRRPLWEFE
   9 ITSGRFNVQEIQG....WENLLAELERLNPAELLY.....PDDWPAGLPLEKRRGAHRRAPWDFD
  10 VSTGEFKATLLKS....KSALYDELFRHRPAEVLL.....APELRENEAFVAQFRKRFPVMLSEA
  11 ITSGRFSVQEIKG....WETLLAELERLNPAELLI.....PDDWPQGLPAEKRRGVRRRAPWDFD
  12 ITSGRFSVQEIKG....WETLLAELERLNPAELLI.....PDDWPQGLPAEKRRGVRRRAPWDFD
  13 VSTGEFKGTVLKS....KSALYDELFRHRPAEVLL.....APELLENGAFLDEFRKRFPVMLSEA
  14 VSTGELKVTHFND....EATLLNEITTINPNEVVI.....NDNISDNLKRQINMVTETITVRETL
  15 TSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKETKTILKSSLSCSLQEGL
  16 TSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQILF.....EKGNLSTETKTVLKGSLSSCLQEGL
  17 TSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKETKTILKSSLSCSLQEGL
  18 TSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKETKTILKSSLSCSLQEGL
  19 TSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKETKTILKSSLSCSLQEGL
  20 TSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKETKTILKSSLSCSLQEGL
  21 LVTGDFYVTGLLD....FTLVCGEIRNLKAREVVL.....GYDLSEEEEQILSRQMNLVLSYEKE
  22 SIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMGKLRQIIQRGGILITER
  23 VSTGEFKGTLLKS....KSALYDELFRHRPAEVLL.....APELRENEAFVAEFRKRFPVMLSEA
  24 VSTGEFKGTLLKS....KSALYDELFRHRPAEVLL.....APELRENEAFVAEFRKRFPVMLSEA
  25 SIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMGKLRQIIQRGGILITER
  26 SIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMGKLRQIIQRGGILITER
  27 SIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMGKLRQIIQRGGILITER
  28 SIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMGKLRQIIQRGGILITER
  29 SIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMGKLRQIIQRGGILITER
  30 SIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMGKLRQIIQRGGILITER
  31 TSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQILF.....EKGNLSTETKTVLKGSLSSCLQEGL
  32 ISTGEFFTCQSSN....LDDLAVELLRLQPSEVLI.....PTSAPDIRNILRPGEPSEHIPKQLP
  33 ISTGEFFTCQSSN....LDDLAVELLRLQPSEVLI.....PTSAPDIRNILRPGEPSEHIPKQLP
  34 PATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTEMLIQRATNVSVRDDRI
  35 PATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTEMLIQRATNVSVRDDRI
  36 TATGELQMLEFEDdse.CTKLDTLMSQVRPMEVVM.....ERNNLSTLANKIVKFNSAPNAIFNE
  37 PATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTEMLIQRATNVSVRDDRI
  38 VSTGEFKGTLLKS....KSALYDELFRHRPAEVLL.....APELRENEAFVAEFRKRFPVMLSEA
  39 PATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTEMLIQRATNVRLKTVRK
  40 TATGELQMLEFEDdse.CTKLDTLMSQVRPMEVVM.....ERNNLSTLANKIVKFNSAPNAIFNE
  41 VATQKIILGQFKDdqd.CSALSCLLSEMRPVEIIK.....PAKVLSYATERTIVRQTRNPLVNNL
  42 STQRKLGLCEFPEndq.FSNLEALLIQIGPKECVLp....GGETTGDMGKLRQVIQRGGILITER
  43 STQRKLGLCEFPEndq.FSNLEALLIQIGPKECVLp....GGETTGDMGKLRQVIQRGGILITER
  44 STQRKLGLCEFPDndq.FSNLEALLIQIGPKECILp....GGETAGDMGKLRQVIQRGGILITER
  45 CAALRFWVGSISDdas.CAALGALLMQVSPKEVLY.....DSKGLSREAQKALRKYTLTGSTAVQ
  46 PATGEVVFDSFQDsas.RSELETRMSSLQPVELLL.....PSALSEQTEALIHRATSVSVQDDRI
  47 PATGEVVFDSFQDsas.RSELETRMSSLQPVELLL.....PSALSEQTEALIHRATSVSVQDDRI
  48 LAGGRFLVNEVNS....EEALEAELARLEPAELLLp....DEDAWPEYLQQRNGVRRRPPWLFDA
  49 LQSGEFKTKLTT-....VDKLDDELARLQAAEILL.....PDSKNAPQLQTASGVTRLNAWQFAA
  50 TSTGGFHMCEFTDdih.RTKLDTLLTQVRPKELIL.....EKSKISQKSIRAIKYCVSSSSIWNF
  51 LQSGEFKTKLTT-....VDKLDDELARLQAAEILL.....PDSKNAPQLQTASGVTRLNAWQFAA
  52 LSTSKIFVINVP-....ETEILNELARLKSREILL.....SENLKSSNISDSI-LKQFNCRITYQ
  53 LSIGTFLVAEYDN....TKDLIEAICRLAPTELLS.....HAKFYQKNEAVIKQLQQHLRITLSE
  54 CAALRFWVGSISDdas.CAALGALLMQVSPKEVLY.....DSKGLSREAQKALRKYTLTGSTAVQ
  55 VATQKIILGQFKDdqd.CSALSCLLSEMRPVEIIK.....PAKVLSYATERTIVRQTRNPLVNNL
  56 STLRKLGVCEFPDndq.FSNLEALLVQIGPKECVMp....GGETAGDMGKLRQIVKRGGILITDR
  57 VSTGEVLVHESSD....EQETLDLLKNYSISQIIC.....PEHLKSSLKERFPGVYTETISEWYF
  58 LSTGTFLVAEYDN....TKDLIEAVYRLAPTELLS.....HAKFYQKNEPVVKQLQQHLRITLSE
  59 LSTGSFFIEECEN....TKELVDEICRLAPSEVLS.....CNKFYNKETAIVMQLQQHLKLTLST
  60 LTTGENLAVLIER....LEDVISEIYSVGAREIVV.....SGSLDADTVAQLRERCGATISIEDG
  61 VSTGEVLVHESSD....EQETLDLLKNYSISQIIC.....PEHLKSSLKERFPGVYTETISEWYF
  62 TTTAHIRIGQFEDddy.RSQLRTLLANVIVVQAIV.....ERGSISSTTKSIINGILFSVPVEHL
  63 LSTSSLGIMFYENgf..FEKLKRDLEKYSPKEIIV.....SENFYYEYSEKLNLSRFLINRVPTW
  64 ISTGIFRLAETA-....ESRLLADILRIEPRELIL.....PDTVFHDPDLRPVFDVLGRVAVPQP
  65 LSTGSFFIEECEN....TKELVDEICRLAPSEVLS.....CNKFYNKETAIVMQLQQHLKLTLST
  66 LTTGENLAVLIER....LEDVISEIYSVGAREIVV.....SGSLDADTVAQLRERCGATISIEDG
  67 SIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMGKLRQIIQRGGILITER
  68 LSSGTTVYDHFQDdfl.RSELQTRLSHFQPCELIY.....SNKLSSESVALLNHYVSTEKTCGRV
  69 LSSGTTVYDHFQDdfl.RSELQTRLSHFQPCELIY.....SNKLSSESVALLNHYVSTEKTCGRV
  70 YAALKIWVGSVQDdds.SAALGALLMQVSPRELIY.....ETSGISKETQRTIRKYASAGSVKMQ
  71 YAALKIWVGSVQDdds.SAALGALLMQVSPRELIY.....ETSGISKETQRTIRKYASAGSVKMQ
  72 VSTGAFFITSFPRaea.ADALQKEFGRVQPSEVLL.....SASVLRSLPELAAILSLYPRLVRTT
  73 ISTGEVVYEEFNDnfm.RSGLEAVILSLSPAELLL.....GQPLSQQTEKFLVAHAGPTSNVRVE
  74 VSTGEIFVQQVY-....LRDLVSAITRIQPKEILL.....DERLLEFHIESGTWYPELVELKKFF
  75 VSTGEIFVQQVY-....LRDLVSAITRIQPKEILL.....DERLLEFHIESGTWYPELVELKKFF
  76 TSIGDFHLGEFEDdkn.CSRLLTLVSHHMPVLFLN.....EKSALSQRTQQIVRTVLGGILKEPV
  77 LAVGEFLGAKVK-....IEELLDLLSKLNIKEILVk....KGEKLPEELEKVLKVYVSELEEEFF
  78 QNDCKFQLLEFLDddf.FTELEATVVLLGPKECLL.....P-SIEGEYSAVKTLLDRNGVMITMP
  79 LSTGEFFTQDSN-....LQRLAGDLTRISPREIVL.....DESLKSFTTHPIYSFIQERKYFLSY
  80 ASVRELGVSEFLDndl.YSNFEALLIQLGVKECIVtqdkgEKEKDPELAKLRQIIDNCGVAIAER
  81 QNDCKFQLLEFLDddf.FTELEATVVLLGPKECLL.....P-SIEGEYSAVKTLLDRNGVMITMP
  82 QNDCKFQLLEFLDddf.FTELEATVVLLGPKECLL.....P-SIEGEYSAVKTLLDRNGVMITMP
  83 LNNGEVVYDEFEEpnlaDEKLQIRIKYLQPIEVLV.....NTDDLPLHVAKFFKDISCPLIHKQE
  84 LSVGEFIGAKVK-....EEELIDFLSKFNIREVLVk....KGEKLPEKLEKVLKLHITELEEEFF
  85 ISTGEVVYEEFNDnfm.RSGLEAVILSLSPAELLL.....GQPLSQQTEKFLVAHAGPTSNVRVE
  86 LNNGEVVYDEFEEpnlaDEKLQIRIKYLQPIEVLV.....NTDDLPLHVAKFFKDISCPLIHKQE
  87 ISTGEVVYEEFNDnfm.RSGLEAVILSLSPAELLL.....GQPLSQQTEKFLVAHAGPTSNVRVE
  88 PILKKLGVSEFVDsda.YTNFEALIVQVGAKECII.....SQSGHESTNGNSAVSINTAEINRLR
  89 PILKKLGVSEFVDsda.YTNFEALIVQVGAKECII.....SQSGHESTNGNSAVSINTAEINRLR
  90 MTNRKLGLAEFPEdsr.FTNVESALVALGCKECLL.....PADCEKSIDLNPLQDVISNCNVLLT
  91 LTRRVLGLAEFLDdsr.FTNLESSLIALGAKECIFpa...ESGKSNECKSLYDSLERCAVMITER
  92 LTRRVLGLAEFLDdsr.FTNLESSLIALGAKECIFpa...ESGKSNECKSLYDSLERCAVMITER
  93 PATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTEMLIQRATNVR------
  94 AGNVRIVISEYIDtps.FSQTEQCIFGLCPTEYILvn...EGSVAPKAKKIASMFTRMEVHNKQQ
  95 TTLRTLTYAEYLDtlq.LTSLDALMAQCNLKELIYl....DKSRCRGGSNSDRGGGAAGVCRRKR
  96 LSTGEFFTQDSN-....LQRLAGDLTRISPREIVL.....DESLKSFTTHPIYSFIQERKYFLSY
  97 ISTGEVVHGEFNDnfm.RSGLEAVIL---------.....-------------------------
  98 CNTGQMYLSDFMDsqi.YIRVVHKLQIYQPTEILI.....PSSSLAPTVSKLATMIKFNVAETVK
  99 CNTGQMYLSDFMDsqi.YIRVVHKLQIYQPTEILI.....PSSSLAPTVSKLATMIKFNVAETVK
 100 LKNPQIILSQFADntt.YAKVITKLKILSPLEIIM.....SNTACAVGNSTKLFTLITENFKNVN
 101 LKNPQIILSQFADntt.YAKVITKLKILSPLEIIM.....SNTACAVGNSTKLFTLITENFKNVN
 102 SSTGDYWTSQSTG....LEGL--------------.....-------------------------
 103 ------KLNKLPNn...FFRMSRAIERLKAMAGSH.....DSSMTEEDKYIIIKMR---------
 104 ------KLNKLPNn...FFRMSRAIERLKAMAGSH.....DSSMTEEDKYIIIKMR---------
 105 ------KLNKLPNn...FFRMSRAIERLKAMAGSH.....DSSMTEEDKYIIIKMR---------
 106 -------------....------------------.....-------------------------


             210       220       230            240                 250
              |         |         |              |                   |
   1 .....PFEPEGEGPLALRRARGALLAYAQRTQGGAL.....SLQP.....FRFYDP.....GAFM
   2 i16rdLVGFGVENASRGLCAAGCLLQYVKDTQRTSLp....HIRS.....ITMERQ.....QDSI
   3 i16rdLVGFGVENASRGLCAAGCLLQYVKDTQRTSLp....HIRS.....ITMERQ.....QDSI
   4 i16rdLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLp....HIRS.....ITMERE.....QDSI
   5 i16rdLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLp....HIRS.....ITMERE.....QDSI
   6 l16kdLRAFGVEKSPLGLSAAGCLLQYAKETQRTALp....HIQS.....ISLIQN.....QDCI
   7 l16rdLVGFGVEQAKLGLCAAGCLIQYVKDTQRTALp....HIRS.....LTWDRQ.....DQSV
   8 i16rdLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLp....HIRS.....ITMERE.....QDSI
   9 f16qdLKGFGCDGLGLAIGAAGCLLAYARETQRTALp....HLRG.....LRHERL.....DDTV
  10 .....PFDPEGEAPLALSRARGALLAYARATQGGAL.....SVRP.....FRLYDP.....GAIV
  11 r16qdLKGFGCQNLTLAIGAAGCLLAYAKETQRTALp....HLRS.....LRHDRL.....DDTV
  12 r16qdLKGFGCQNLTLAIGAAGCLLAYAKETQRTALp....HLRS.....LRHDRL.....DDTV
  13 .....PFEPEGEGPLALRRARGALLAYAQRTQGGAL.....SLQP.....FRFYDP.....GAFM
  14 sse..IYSVNQTEHKLMYQATQLLLDYIHHTQKRDLs....HIED.....VVQYAA.....IDYM
  15 i47dsIGLTPGEKSELALSALGGCVFYLKKCLIDQE.....LLSM.....ANFEEYi20kaYQRM
  16 i45dsVGLTPGEESELALSALGGIVFYLKKCLIDQE.....LLSM.....ANFEEYf20kaSQRM
  17 i47dsIGLTPGEKSELALSALGGCVFYLKKCLIDQE.....LLSM.....ANFEEYi20kaYQRM
  18 i47dsIGLTPGEKSELALSALGGCVFYLKKCLIDQE.....LLSM.....ANFEEYi20kaYQRM
  19 i47dsIGLTPGEKSELALSALGGCVFYLKKCLIDQE.....LLSM.....ANFEEYi20kaYQRM
  20 i47dsIGLTPGEKSELALSALGGCVFYLKKCLIDQE.....LLSM.....ANFEEYi20kaYQRM
  21 sfed.LHLLDLRLATVEQTASSKLLQYVHRTQMRELn....HLKP.....VIRYEI.....KDFL
  22 k27mnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN.....FGQFe....LTTFDF.....SQYM
  23 .....PFEPQGEGPLALRRAQGALLAYARATQGGAL.....SVRP.....FRLYDP.....GAFV
  24 .....PFEPQGEGPLALRRAQGALLAYARATQGGAL.....SVRP.....FRLYDP.....GAFV
  25 k27mnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN.....FGQFe....LTTFDF.....SQYM
  26 k27mnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN.....FGQFe....LTTFDF.....SQYM
  27 k27mnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN.....FGQFe....LTTFDF.....SQYM
  28 k27mnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN.....FGQFe....LTTFDF.....SQYM
  29 k27mnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN.....FGQFe....LTTFDF.....SQYM
  30 k27mnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN.....FGQFe....LTTFDF.....SQYM
  31 i45dsVGLTPGEESELALSALGGIVFYLKKCLIDQE.....LLSM.....ANFEEYf20kaSQRM
  32 t30ksLEGMGCEGLPLAIRAAGGLLEYIEDTQKAHVv....PIQP.....LKTYGL.....TDFL
  33 t30ksLEGMGCEGLPLAIRAAGGLLEYIEDTQKAHVv....PIQP.....LKTYGL.....TDFL
  34 r34sqSLSGVINLEKPVICALAAVIRYLKEFNLEKM.....LSKPesf..KQLSSG.....MEFM
  35 r34sqSLSGVINLEKPVICALAAVIRYLKEFNLEKM.....LSKPesf..KQLSSG.....MEFM
  36 v32evLKSYYDTGKKVGFSAFGGLLYYLKWLKLDKN.....LISMknikeYDFVKS.....QHSM
  37 r34sqSLSGVINLEKPVICALAAVIRYLKEFNLEKM.....LSKPesf..KQLSSG.....MEFM
  38 .....PFEPQGEGPLALRRAQGALLAYARATQGGAL.....SVRP.....FRLYDP.....GAFV
  39 l55sqSLSGVINLEKPVICALAAVIRYLKEFNLEKM.....LSKPesf..KQLSSG.....MEFM
  40 v32evLKSYYDTGKKVGFSAFGGLLYYLKWLKLDKN.....LISMknikeYDFVKS.....QHSM
  41 v50lsELATEDKNGSLALSALGGAIYYLRQAFLDES.....LLRF.....AKFESLp10neKQHM
  42 k27inSAALPEMENQVAVSSLSAVIKFLELLSDDSN.....FGQFe....LATFDF.....SQYM
  43 k27inSAALPEMENQVAVSSLSAVIKFLELLSDDSN.....FGQFe....LATFDF.....SQYM
  44 k27mnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN.....FGQFe....LATFDF.....SQYM
  45 l34wnCAVDGLNECDVALSALGELINHLSRLKLEDVlk...HGDI.....FPYQVY.....RGCL
  46 r34sqIISGIVNLEKPVICSLAAIIKYLKEFNLEKM.....LSKPenf..KQLSSK.....MEFM
  47 r34sqIISGIVNLEKPVICSLAAIIKYLKEFNLEKM.....LSKPenf..KQLSSK.....MEFM
  48 d15hdLSGFGIENNPQATAAAGALLGYIEETQKQRLp....HLTS.....ITMETV.....GEAI
  49 d17lrGFGLDGKEHAVAIGAAGALLNYIRLTQNLMPq....HLDG.....LSLETD.....SQYI
  50 i32pkILKSYLSEKPLAISAFGALFWYLRQLKLDKD.....MCSMgnfdeYDASQQ.....STSL
  51 d17lrGFGLDGKEHAVAIGAAGALLNYIRLTQNLMPq....HLDG.....LSLETD.....SQYI
  52 v21irDIKGIGEISNSQICAIGSILEYLSLTQKQNIp....HLPI.....PKIINF.....HNYM
  53 y23ssLDGFGLQGLVPAINAAGALLSYIQDKLLLPIs....HLSI.....PKIYGQ.....QKHL
  54 l34wnCAVDGLNECDVALSALGELINHLSRLKLEDVlk...HGDI.....FPYQVY.....RGCL
  55 v50lsELATEDKNGSLALSALGGAIYYLRQAFLDES.....LLRF.....AKFESLp10neKQHM
  56 k27vtSAALPEMEKQVAMSALAAVMKYLELLSDESN.....FGQFv....MTNFDL.....SQYM
  57 s12nlKDIHHFELSPLALKALAALIKYVKYTMIAEDl....NLKP.....PLLISQ.....RDYM
  58 h23ssLDGFGLQGLVPAINAAGALLSYIQDKLLLPIs....HLSI.....PKIYGQ.....HKHL
  59 y23asLDGFGLKGLVPAINAAGGLLSYIQDKLLLPTk....HIAI.....PQTRGK.....QQKL
  60 etdehVTIIEHLNNEDITKTFLRLYTYLKRTQKRSLd....HLQP.....VQVYEL.....EEAM
  61 s12nlKDIHHFELSPLALKALAALIKYVKYTMIGEDl....NLKP.....PLLISQ.....RDYM
  62 l41ssILPKPSTDWQLALSAFGAIFWYLRDSLIDVD.....MLSMrn...VTIYNSn15wnGKNL
  63 h19lgLSSLGFDEEKPYYISIFLIINHIKNNLKNLLs....NIDK.....IDINND.....SSYM
  64 a20vgTLDGFGSFSRAELAAASAAVSYVEKTQLQERp....ALGI.....PERESA.....ASTL
  65 y23asLDGFGLKGLVPAINAAGGLLSYIQDKLLLPTk....HIAI.....PQTRGK.....QQKL
  66 etdehVTIIEHLNNEDITKTFLRLYTYLKRTQKRSLd....HLQP.....VQVYEL.....EEAM
  67 k27mnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN.....FGQFe....LTTFDF.....SQYM
  68 v36elHMEKVKSLHSLSIICLDMAISYLMEFSLEDL.....FVASnf...YQPFDS.....ISSM
  69 v36elHMEKVKSLHSLSIICLDMAISYLMEFSLEDL.....FVASnf...YQPFDS.....ISSM
  70 l33wlSALDCTMNQDVVICALGGLIGHLTRLMLHDAlk...NGEV.....LPYHVY.....KTCL
  71 l33wlSALDCTMNQDVVICALGGLIGHLTRLMLHDAlk...NGEV.....LPYHVY.....KTCL
  72 g23rnLDCLTLLPHSPDLAAAGALIAYLEETTRHPLs....HVSA.....ITRYHI.....HDFV
  73 r46clTVHTIMNMPHLTVQALALTFCHLKQFGFERI.....LYQGas...FRSLSS.....NTEM
  74 i31rqLKIQFQTFTQKELAALRNTLIYVSNHLPDFSi....NFQI.....PQRQLA.....TAIM
  75 i31rqLKIQFQTFTQKELAALRNTLIYVSNHLPDFSi....NFQI.....PQRQLA.....TAIM
  76 p44dhLGLTPNDNYKLALKALGQCIFFIHKCKLEPK.....VLPMar...YQLY--v18lrRSHM
  77 e14vlSLQAFGFEEDTYSLPLGAVYKYAKTTQKGYT.....PLIPr....PKPYRD.....EGFV
  78 k25edATGLKELQLQLASNALKTAIKYLDLVNDAGN.....LGHYe....IKQLDL.....NRFV
  79 v19eiDPSFIKYCTKLEVTAGCTLISYIADRLQNSHp....NIQP.....PIRVSL.....NEYM
  80 s23raASLLPQTDLKLAMGSASALIKYLGILHDPSN.....FGQYq....LYQHDL.....AQFM
  81 k25edATGLKELQLQLASNALKTAIKYLDLVNDAGN.....LGHYe....IKQLDL.....NRFV
  82 k25edATGLKELQLQLASNALKTAIKYLDLVNDAGN.....LGHYe....IKQLDL.....NRFV
  83 y12ikVMNEKIQLSPSLIRLVSKLYSHMVEYNNEQV.....MLIPsi...YSPFAS.....KIHM
  84 e14vpSIKAFGFQDEDLSLSLGAVYRYAKATQKSFT.....PLIPk....PKPYVD.....EGYV
  85 r46clTVQTIMNMPHLTVQALALTFCHLKQFGFERI.....LYQGas...FRSLSS.....NTEM
  86 y12ikVMNEKIQLSPSLIRLVSKLYSHMVEYNNEQV.....MLIPsi...YSPFAS.....KIHM
  87 r46clTVHTIMNMPHLTVQALALTFCHLKQFGFERI.....LYQGas...FRSLSS.....NTEM
  88 n36vtHALVPELGLQLAMASCNALLRYLGPALLNPD.....MEDDre9lhLYHHNL.....EQYM
  89 n36vtHALVPELGLQLAMASCNALLRYLGPALLNPD.....MEDDre9lhLYHHNL.....EQYM
  90 e25vePVRDLLSQFDYALGPLGALLSYAELLADDTN.....YGNYt....IEKYNL.....NCYM
  91 k23iePVRDLVSGFDLATPALGALLSFSELLSNEDN.....YGNFt....IRRYDI.....GGFM
  92 k23iePVRDLVSGFDLATPALGALLSFSELLSNEDN.....YGNFt....IRRYDI.....GGFM
  93 .....-------------------------------.....----.....------.....----
  94 l13esVHLDYKDEAEKQNENIKECLQILHSNAADEY.....SISEkys..IFNYGT.....HGNM
  95 a66vpEDRLALSNCPLASRAIEYLVSNIIDNFDATN.....HRAFy....LKHTIP.....STFM
  96 v19eiDPSFIKYCTKLEVTAGCTLISYIADRLQNSHp....NIQP.....PIRVSL.....NEYM
  97 .....-------------------------------.....----.....------.....----
  98 i29kdLKIEEIIDKTFALCAASAAISYMEEIISKSSrn...-LNAfrklrIQFEGT.....ENTM
  99 i29kdLKIEEIIDKTFALCAASAAISYMEEIISKSSrn...-LNAfrklrIQFEGT.....ENTM
 100 f27fsTVLMEVQSKYYCLAAVAALLKYVEFIQNSVY.....APKSlk...ICFQGS.....EQTA
 101 f27fsTVLMEVQSKYYCLAAVAALLKYVEFIQNSVY.....APKSlk...ICFQGS.....EQTA
 102 .....-------------------------------.....----.....------.....----
 103 .....----FDIEAVNMIRSFGALLLFLDETRMGVTdd8tsPIKS.....IKTFTL.....GNLV
 104 .....----FDIEAVNMIRSFGALLLFLDETRMGVTdd8tsPIKS.....IKTFTL.....GNLV
 105 .....----FDIEAVNMIRSFGALLLFLDETRMGVTdd8tsPIKS.....IKTFTL.....GNLV
 106 .....-------------------------------.....----.....------.....----


             260            270       280        290       300
              |              |         |          |         |
   1 RLPEATLRALEVFEPLRGQ.....DTLFSVLDETRT.APGRRLLQSWLRHPLLDRG
   2 IMDAATRRNLEITQNLAGGve...NTLAAVLDCTVT.PMGSRMLKRWLHMPVRN--
   3 IMDAATRRNLEITQNLAGGve...NTLAAVLDCTVT.PMGSRMLKRWLHMPVRN--
   4 IMDAATRRNLEITQNLAGGae...NTLASVLDCTVT.PMGSRMLKRWLHMPVRD--
   5 IMDAATRRNLEITQNLAGGae...NTLASVLDCTVT.PMGSRMLKRWLHMPVRD--
   6 QLDAATRRNLELTQNLAGGte...NTLASVLDKCVT.PMGSRLLKRWIHQPVRD--
   7 ILDAATRRNLELTHNLAGGtd...NTLAEVLDHCAT.PMGSRMLKRWIHQPMRD--
   8 IMDAATRRNLEITQNLAGGae...NTLASVLDCTVT.PMGSRMLKRWLHMPV----
   9 ILAGASRRNLELDVNLSGGrd...NTLQSVIDRCQT.AMGSRLLGRWLNRPLRDR-
  10 RLPEASLKALEVFEPLRGQ.....DTLFGVLDETRT.APGRRLLQAWLRHPLLERG
  11 ILDGASRRNLELDINLSGGre...NTLQSVVDRCQT.AMASRLMSRWLNRPLRDR-
  12 ILDGASRRNLELDINLSGGre...NTLQSVVDRCQT.AMASRLMSRWLNRPLRDR-
  13 RLPEATLRALEVFEPLRGQ.....DTLFSVLDETRT.APGRRLLQSWLRHPLLDRG
  14 KMDFYAKRNLELTESIRLKskk..GTLLWLMDETKT.PMGARRLKQWIDRPLISKE
  15 VLDAVTLNNLEIFLNGTNGste..GTLLERVDTCHT.PFGKRLLKQWLCAPLCN--
  16 VLDAVTLNNLEIFLNGTNGste..GTLLERLDTCHT.PFGKRLLKQWLCAPLCS--
  17 VLDAVTLNNLEIFLNGTNGste..GTLLERVDTCHT.PFGKRLLKQWLCAPLCN--
  18 VLDAVTLNNLEIFLNGTNGste..GTLLERVDTCHT.PFGKRLLKQWLCAPLCN--
  19 VLDAVTLNNLEIFLNGTNGste..GTLLERVDTCHT.PFGKRLLKQWLCAPLCN--
  20 VLDAVTLNNLEIFLNGTNGste..GTLLERVDTCHT.PFGKRLLKQWLCAPLCN--
  21 QMDYATKASLDLVENARSGkkq..GSLFWLLDETKT.AMGMRLLRSWIHRPLIDKE
  22 KLDIAAVRALNLFQGSVEDttgs.QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKN
  23 RLPEASLKALEVFEPLRGQ.....DTLFGVLDETRT.APGRRLLQAWLRHPLLERG
  24 RLPEASLKALEVFEPLRGQ.....DTLFGVLDETRT.APGRRLLQAWLRHPLLERG
  25 KLDIAAVRALNLFQGSVEDttgs.QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKN
  26 KLDIAAVRALNLFQGSVEDttgs.QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKN
  27 KLDIAAVRALNLFQGSVEDttgs.QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKN
  28 KLDIAAVRALNLFQGSVEDttgs.QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKN
  29 KLDIAAVRALNLFQGSVEDttgs.QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKN
  30 KLDIAAVRALNLFQGSVEDttgs.QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKN
  31 VLDAVTLNNLEIFLNGTNGste..GNLLERLDTCHT.PFGKRLLKQWLCAPLCS--
  32 VLDHQTRRNLEINQTVRDGsfh..GSLLWALDRTST.TMGSRALRRWLLQPLLD--
  33 VLDHQTRRNLEINQTVRDGsfh..GSLLWALDRTST.TMGSRALRRWLLQPLLD--
  34 RINGTTLRNLEILQNQTDMktk..GSLLWVLDHTKT.SFGRRKLKNWVTQPLL---
  35 RINGTTLRNLEMVQNQTDMktk..GSLLWVLDHTKT.SFGRRKLKNWVTQPLL---
  36 VLDGITLQNLEIFSNSFDGsdk..GTLFKLFNRAIT.PMGKRMMKKWLMHPLLRKN
  37 RINGTTLRNLEMVQNQTDMktk..GSLLWVLDHTKT.SFGRRKLKNWVTQPLL---
  38 RLPEASLKALEVFEPLRGQ.....DTLFGVLDETRT.APGRRLLQAWLRHPLLERG
  39 RINGTTLRNLEILQNQTDMktk..GSLLWVLDHTKT.SFGRRKLKNWVTQPLL---
  40 VLDGITLQNLEIFSNSFDGsdk..GTLFKLFNRAIT.PMGKRMMKKWLMHPLLRKN
  41 VLDAAALENLEIFENSRNGgys..GTLYAQLNQCIT.ASGKRLLKTWLARPLYN--
  42 KLDMAAVRALNLFQGSVEDttgs.QSLAALLNKCKT.AQGQRLVNQWIKQPLMDRN
  43 KLDMAAVRALNLFQGSVEDttgs.QSLAALLNKCKT.AQGQRLVNQWIKQPLMDRN
  44 KLDMAAVRALNLFQGSVEDttgs.QSLAAFLNKCKT.AQGQRLVSQWIKQPLMDKN
  45 RIDGQTMVNLEIFNNSCDGgps..GTLYKYLDNCVS.PTGKRLLRNWICHPLKD--
  46 TINGTTLRNLEILQNQTDMktk..GSLLWVLDHTKT.SFGRRKLKKWVTQPLL---
  47 TINGTTLRNLEILQNQTDMktk..GSLLWVLDHTKT.SFGRRKLKKWVTQPLL---
  48 TMNAATRRHLELDTRVDGEsr...HTLLGVLDSTVT.PMGGRLLRRWLHRPLR---
  49 GMDAATRRNLEITQTLSGKks...PTLMSTLDLCAT.HMGSRLLALWLHHPLRNR-
  50 LMNGQTLKNLEIFSNSFDGgse..GTLFHLLCRCVT.PFGKRLFHTWLCHPLR---
  51 GMDAATRRNLEITQTLSGKks...PTLMSTLDLCAT.HMGSRLLALWLHHPLRNR-
  52 TIDFSTRRNLEIVTNLQGNly...GSVLNTLNHTVT.TQGGRLLYHFLSSPLTN--
  53 LIDKASQTNLELLSPIHGEhgk..GSLLQVMERTST.PMGGRLLRNTLINPFYD--
  54 RIDGQTMVNLEIFNNSCDGvlq..GPLNKYLENCVS.PTGKRLLRNWICHPLKD--
  55 VLDAAALENLEIFENSRNGgys..GTLYAQLNQCIT.ASGKRLLKTWLARPLYN--
  56 KLDNAAVGALNLFPGSAEDtsgt.QSLAGLLNKCKT.PQGQRLVNQWIKQPLMDKN
  57 ILDSATVENLSLIPGDRGKn....--LFDVLNNTET.PMGARLLKKWILHPLVDRK
  58 LIDKASQTNLELLSAIHGEhgk..GSLLQVMERTST.PMGGRLLRNTLVNPFYD--
  59 LIDTASQVNLELLAPLNDPqgk..NSLLRIMDHTST.PMGGRLLRQILISPFYN--
  60 KIDLYSKRNLELTETIRSKnkk..GSLLWLLDETKT.AMGGRLLKQWIDRPLI---
  61 ILDSATVENLSWIPGDRGKn....--LFDVLNNTET.PMGARLGKKWILHPLVDRK
  62 ILDGTALENLNIVPNGRDShl...TSLYYVINKCST.PFGRRLLRSWLLQPTCD--
  63 FLDDVTQVNLELVKNNNDFssq..YSLYSVLNDCKT.AMGKRLLREFILNPILN--
  64 FIDPATRANLELAKTLSGSrd...GSLLKSLDRTMT.SGGARLLAERLMSPLTD--
  65 LIDTASQVNLELLAPLNDPqgk..NSLLRIMDHTST.PMGGRLLRQILISPFYN--
  66 KIDLYSKRNLELTETIRSKnkk..GSLLWLLDETKT.AMGGRLLKQWIDRPLI---
  67 KLDIAAVRALNLFQGSVEDttgs.QSLAALLNKCKT.PQG----------------
  68 VLSKQALEGLELFVNQTDHtpv..GSLFWVLDRTYT.RFGQRMLQRWLQKPLVDKE
  69 VLSKQALEGLELFVNQTDHtpv..GSLFWVLDRTYT.RFGQRMLQRWLQKPLVDKE
  70 RMDGQTLVNLEIFINNFNGgss..GTLYKHLNHCVT.ASGKRMLRRWICHPLKD--
  71 RMDGQTLVNLEIFINNFNGgss..GTLYKHLNHCVT.ASGKRMLRRWICHPLKD--
  72 EIDDATRKNLEILQNLHDStha..HSLFETLNYTHT.AMGTRLLRYWLHHPLRS--
  73 TLSANTLQQLEVVKNNSDGses..GSLFHNMNHTLT.VYGSRLLRHWVTHPLCDRN
  74 QIDSRTSTALELHSTVRDNnkk..GSLLSSIRRTVT.PSGTRLLSQWLSGPSLD--
  75 QIDSRTSTALELHSTVRDNnkk..GSLLSSIRRTVT.PSGTRLLSQWLSGPSLD--
  76 VLDATTLSNLRII---GEE.....HSLLSTLDHCCT.KFGKRLLHHWLCAPSCD--
  77 RLDIKAIKGLEILESLEGRkd...ISLFKVIDRTLT.GMGRRRLKFRLLSPFRSRE
  78 HLDSAAVAALNIMPKPGTHps8rwQSVLGVLDHCRT.PQGHRLMGQWVKQPLRSRN
  79 IIGESAMKGLEIRSSLYQNryt..GSLLHAINKTVT.KSGSRLLTRRLCAPST---
  80 KLDAAALKALNLMPGARDGakn..MSLYGLLNHCKT.PVGSRLLSQWLKQPLMN--
  81 HLDSAAVAALNIMPKPGTHps8rwQSVLGVLDHCRT.PQGHRLMGQWVKQPLRSRN
  82 HLDSAAVAALNIMPKPGTHps8rwQSVLGVLDHCRT.PQGHRLMGQWVKQPLRSRN
  83 LLDPNSLQSLDIFTHDGGK.....GSLFWLLDHTRT.SFGLRMLREWILKPLVD--
  84 KLDLKAVKGLEITESIEGRkd...LSLFKVVDRTLT.GMGRRRLRFRLLNPFR---
  85 TLSANTLQQLEVVKNNSDGses..GSLFHNMNHTLT.VYGSRLLRHWVTHPLCDRN
  86 LLDPNSLQSLDIFTHDGGK.....GSLFWLLDHTRT.SFGLRMLREWILKPLVD--
  87 TLSANTLQQLEVVKNNSDGses..GSLFHNMNHTLT.VYGSRLLRHWVTHPLCDRN
  88 RLDIAAVRSLNLLPPPNGNahkt.MSLYGLLNHCRT.AMGARNLRRWIVQPLLD--
  89 RLDIAAVRSLNLLPPPNGNahkt.MSLYGLLNHCRT.AMGARNLRRWIVQPLLD--
  90 RLDSAAVRALNIAEGKTDVnkn..FSLFGLMNRTCTvGMGKRLLNRWLKQPLLD--
  91 RLDSAAMRALNVMESKTDAnkn..FSLFGLMNRTCTaGMGKRLLHMWLKQPLVD--
  92 RLDSAAMRALNVMESKTDAnkn..FSLFGLMNRTCTaGMGKRLLHMWLKQPLVD--
  93 -------------------.....------------.-------------------
  94 LIDSCAVEALELFQLNYNYle6nnLTLYNVLNKCKT.LPGEKLLRDWLSRPLC---
  95 KLDTAAIQALHIIHQKPEArgslpTSVYSWLNRCVT.GMGSRMMRQWLLQPLRN--
  96 IIGESAMKGLEIRSSLYQNryt..GSLLHAINKTVT.KSGSRLLTRRLCAPST---
  97 -------------------.....------------.-------------------
  98 LIDSKTVRGLELVENKLDKng...ISLWKFLDTTST.KMGQRSLRNSILQPLTDRG
  99 LIDSKTVRGLELVENKLDKng...ISLWKFLDTTST.KMGQRSLRNSILQPLTDRG
 100 MIDSSSAQNLELLINNQDYrnn..HTLFGVLNYTKT.PGGSRRLRSNILEPLVD--
 101 MIDSSSAQNLELLINNQDYrnn..HTLFGVLNYTKT.PGGSRRLRSNILEPLVD--
 102 -------------------.....------------.-------------------
 103 EIDFNTIQALDILPKETENkk7qgRSLYQLMDKCRS.TVGKKCLRKWFRNPTTDRD
 104 EIDFNTIQALDILPKETENkk7qgRSLYQLMDKCRS.TVGKKCLRKWFRNPTTDRD
 105 EIDFNTIQALDILPKETENkk7qgRSLYQLMDKCRS.TVGKKCLRKWFRNPTTDRD
 106 -------------------.....------------.-------------------