; SAM: prettyalign v3.2 (July 31, 2000) compiled 08/11/00_16:27:51 ; (c) 1992-2000 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequences correspond to the following labels: ; 1 T0116-1-300 ; 2 gi|79102|pir||A28668_7:319 ; 3 gi|417330|sp|P10339|MUTS_SALTY_7:319 ; 4 gi|127556|sp|P23909|MUTS_ECOLI_6:317 ; 5 gi|4887554|emb|CAB43497.1|_6:317 ; 6 gi|1171081|sp|P44834|MUTS_HAEIN_3:317 ; 7 gi|9654962|gb|AAF93703.1|_7:322 ; 8 gi|1592569|gb|AAB97931.1|_6:315 ; 9 gi|127555|sp|P27345|MUTS_AZOVI_3:315 ; 10 gi|7387928|sp|Q9ZIX6|MUTS_THECA_8:305 ; 11 gi|7229490|gb|AAF42850.1|_4:315 ; 12 gi|7108493|gb|AAF36440.1|AF126491_1_4:315 ; 13 gi|2497995|sp|Q56215|MUTS_THEAQ_2:300 ; 14 gi|7328284|emb|CAB82466.1|_3:301 ; 15 gi|7512474|pir||JC5839_395:784 ; 16 gi|6754744|ref|NP_034960.1|_394:781 ; 17 gi|7512473|pir||JC5840_395:784 ; 18 gi|1709123|sp|P52701|MSH6_HUMAN_395:784 ; 19 gi|1082386|pir||A56742_327:716 ; 20 gi|4504191|ref|NP_000170.1|_395:784 ; 21 gi|123080|sp|P10564|HEXA_STRPN_4:303 ; 22 gi|1000875|gb|AAB59568.1|_19:354 ; 23 gi|2497996|sp|Q56239|MUTS_THETH_10:308 ; 24 gi|1871501|dbj|BAA09880.1|_10:308 ; 25 gi|2135744|pir||I37550_19:354 ; 26 gi|4557761|ref|NP_000242.1|_19:354 ; 27 gi|7448104|pir||I64827_19:354 ; 28 gi|1000879|gb|AAB59570.1|_19:354 ; 29 gi|1000883|gb|AAB59571.1|_19:354 ; 30 gi|1000877|gb|AAB59569.1|_19:354 ; 31 gi|2506881|sp|P54276|MSH6_MOUSE_394:781 ; 32 gi|7448108|pir||S74860_56:385 ; 33 gi|7404405|sp|P73769|MUTS_SYNY3_22:351 ; 34 gi|387849|gb|AAB60711.1|_175:543 ; 35 gi|110917|pir||A32495_175:543 ; 36 gi|6320302|ref|NP_010382.1|_299:667 ; 37 gi|400971|sp|P13705|MSH3_MOUSE_175:543 ; 38 gi|2145507|pir||S62790_18:307 ; 39 gi|1083296|pir||JC4019_189:578 ; 40 gi|1588283|prf||2208298A_299:667 ; 41 gi|6226648|sp|O04716|MSH6_ARATH_367:747 ; 42 gi|6678938|ref|NP_032654.1|_19:354 ; 43 gi|726086|gb|AAA75027.1|_19:354 ; 44 gi|1709122|sp|P54275|MSH2_RAT_19:354 ; 45 gi|9294039|dbj|BAB01996.1|_255:604 ; 46 gi|118951|sp|P20585|MSH3_HUMAN_220:585 ; 47 gi|4505249|ref|NP_002430.1|_211:576 ; 48 gi|9106782|gb|AAF84525.1|AE003995_7_39:355 ; 49 gi|7379009|emb|CAB83555.1|_4:314 ; 50 gi|7492209|pir||T41262_362:716 ; 51 gi|7227419|gb|AAF42468.1|_4:314 ; 52 gi|6647605|sp|Q9ZDM9|MUTS_RICPR_13:338 ; 53 gi|7387913|sp|O84797|MUTS_CHLTR_4:315 ; 54 gi|6224917|gb|AAF06013.1|AF193018_1_255:604 ; 55 gi|2104549|gb|AAB57798.1|_374:760 ; 56 gi|1079288|pir||S53609_19:353 ; 57 gi|6226653|sp|P74926|MUTS_THEMA_3:299 ; 58 gi|7190210|gb|AAF39048.1|_4:315 ; 59 gi|7387924|sp|Q9Z6W5|MUTS_CHLPN_5:321 ; 60 gi|7404403|sp|P49849|MUTS_BACSU_3:300 ; 61 gi|1619909|gb|AAB16999.1|_3:299 ; 62 gi|7331984|gb|AAF60672.1|_840:1223 ; 63 gi|3914075|sp|O51737|MUTS_BORBU_4:312 ; 64 gi|8473172|sp|P56883|MUTS_RHIME_21:348 ; 65 gi|7189834|gb|AAF38705.1|_5:321 ; 66 gi|1002520|gb|AAB19235.1|_1:294 ; 67 gi|1000873|gb|AAB59567.1|_19:338 ; 68 gi|135075|sp|P26359|SWI4_SCHPO_95:455 ; 69 gi|1076927|pir||S22569_5:363 ; 70 gi|4775578|emb|CAB42555.1|_354:699 ; 71 gi|4775580|emb|CAB42556.1|_47:392 ; 72 gi|6093453|sp|O83348|MUTS_TREPA_5:319 ; 73 gi|3319876|emb|CAA07684.1|_94:473 ; 74 gi|6321912|ref|NP_011988.1|_69:414 ; 75 gi|172000|gb|AAA34801.1|_69:414 ; 76 gi|7294307|gb|AAF49656.1|_250:624 ; 77 gi|3914079|sp|O66652|MUTS_AQUAE_4:310 ; 78 gi|1174416|sp|P43248|MSH2_DROME_9:351 ; 79 gi|6166561|sp|O13921|MSH1_SCHPO_50:393 ; 80 gi|3914053|sp|O13396|MSH2_NEUCR_14:341 ; 81 gi|7287834|gb|AAF44872.1|AE003406_77_24:355 ; 82 gi|7298155|gb|AAF53392.1|_24:355 ; 83 gi|6319935|ref|NP_010016.1|_152:495 ; 84 gi|3024198|sp|P70755|MUTS_AQUPY_5:307 ; 85 gi|7269404|emb|CAB81364.1|_94:456 ; 86 gi|448278|prf||1916402A_152:494 ; 87 gi|3914062|sp|O65607|MSH3_ARATH_94:456 ; 88 gi|4151103|emb|CAA07342.1|_21:366 ; 89 gi|7522263|pir||T39832_21:366 ; 90 gi|4775576|emb|CAB42554.1|_29:348 ; 91 gi|3914056|sp|O24617|MSH2_ARATH_27:346 ; 92 gi|4139230|gb|AAD04176.1|_27:346 ; 93 gi|6981224|ref|NP_034959.1|_143:373 ; 94 gi|3886083|gb|AAC78226.1|_17:324 ; 95 gi|9864530|gb|AAG00261.1|_10:389 ; 96 gi|7522430|pir||T38256_2:232 ; 97 gi|7547005|gb|AAF63754.1|AF242852_1_64:256 ; 98 gi|6321109|ref|NP_011187.1|_101:317 ; 99 gi|730066|sp|P40965|MSH4_YEAST_101:317 ; 100 gi|4336728|gb|AAD17920.1|_150:361 ; 101 gi|4505251|ref|NP_002431.1|_150:361 ; 102 gi|2072992|gb|AAC46142.1|_1:130 ; 103 gi|8515837|gb|AAF76200.1|_188:335 ; 104 gi|3914066|sp|Q19272|MSH5_CAEEL_188:335 ; 105 gi|3831701|gb|AAC70065.1|_188:335 ; 106 gi|7490460|pir||T37626_49:191 10 20 30 40 50 | | | | | 1 MEGMLKGEGPGPLPPL........LQQYVELRDQYPDYLLLFQVG....DFYECFG.EDAERLAR 2 -------KDFSNHTPM........MQQYLKLKAQHPEILLFYRMG....DFYELFY.DDAKRASQ 3 -------KDFSNHTPM........MQQYLKLKAQHPEILLFYRMG....DFYELFY.DDAKRASQ 4 --------NFDAHTPM........MQQYLRLKAQHPEILLFYRMG....DFYELFY.DDAKRASQ 5 --------NFDAHTPM........MQQYLKLKAQHPEILLFYRMG....DFYELFY.DDAKRASQ 6 -----SEENFQQHTPM........MQQYLKLKAENPDILLFYRMG....DFYELFY.DDAKKAAA 7 ----SPSESLSHHTPM........MQQYLRLKAENPDILLFYRMG....DFYELFY.DDAKRASE 8 --------NFDAHTPM........MQQYLKLKAQHPEILLFYRMG....DFYELFY.DDAKRASQ 9 --------SLSQHTPM........MQQYWKLKREHPDQLMFYRMG....DFYELFY.EDAKKAAK 10 --VMLKGEGPGPLPPL........LQQYVELRDRYPDYLLLFQVG....DFYECFG.EDAERLAR 11 ---------LSQHTPM........MQQYFKLKHQHPDQLMFYRMG....DFYELFY.EDAKKAAK 12 ---------LSQHTPM........MQQYFKLKHQHPDQLMFYRMG....DFYELFY.EDAKKAAK 13 -EGMLKGEGPGPLPPL........LQQYVELRDQYPDYLLLFQVG....DFYECFG.EDAERLAR 14 -----------NVTPM........MQQYLKIKSEYQDCLLFFRLG....DFYEMFY.EDAKEASR 15 -TLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVS 16 -TLYVPEEFLNSCTPG........MRKWWQLKSQNFDLVIFYKVG....KFYELYH.MDAVIGVS 17 -TLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVS 18 -TLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVS 19 -TLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVS 20 -TLYVPEDFLNSCTPG........MRKWWQIKSQNFDLVICYKVG....KFYELYH.MDALIGVS 21 ----------EKLSPG........MQQYVDIKKQYPDAFLLFRMG....DFYELFY.EDAVNAAQ 22 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 23 -EGMLKGEGPGPLPPL........LQQYVELRDRYPDYLLLFQVG....DFYECFG.EDAERLAR 24 -EGMLKGEGPGPLPPL........LQQYVELRDRYPDYLLLFQVG....DFYECFG.EDAERLAR 25 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 26 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 27 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 28 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 29 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 30 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 31 -TLYVPEEFLNSCTPG........MRKWWQLKSQNFDLVIFYKVG....KFYELYH.MDAVIGVS 32 ---------RQKLTPM........FQHYTEVKEQYQGALLLYRVG....DFFECFF.QDAVIIAR 33 ---------RQKLTPM........FQHYTEVKEQYQGALLLYRVG....DFFECFF.QDAVIIAR 34 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAAR 35 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAAR 36 RTLYIPSSAWNKFTPF........EKQYWEIKSKMWDCIVFFKKG....KFFELYE.KDALLANA 37 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAAR 38 ----------PPLPPL........LQQYVELRDRYPDYLLLFQVG....DFYECFG.EDAERLAR 39 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAAR 40 RTLYIPSSAWNKFTPF........EKQYWEIKSKMWDCIVFFKKG....KEFELYE.KDALLANA 41 RTLYLPPDFVKKLTGG........QRQWWEFKAKHMDKVVFFKMG....KFYELFE.MDAHVGAK 42 ---------------F........VRFFEGMPEKPSTTVRLFDRG....DFYTAHG.EDALLAAR 43 ---------------F........VRFFEGMPEKPSTTVRLFDRG....DFYTAHG.EDALLAAR 44 ---------------F........VRFFEGMPEKPSTTVGLFDRG....DFYTAHG.EDALLAAR 45 KTLHIPPDVFKKMSAS........QKQYWSVKSEYMDIVLFFKVG....KFYELYE.LDAELGHK 46 ---SANKRSKSIYTPL........ELQYIEMKQQHKDAVLCVECG....YKYRFFG.EDAEIAAR 47 ---SANKRSKSIYTPL........ELQYIEMKQQHKDAVLCVECG....YKYRFFG.EDAEIAAR 48 --KPEGGKGMAEHTPL........MKQYFAAKAEYPDLLLFFRMG....DFYELFH.QDARKAAR 49 ----------SAVSPM........MQQYLGIKAQHTDKLVFYRMG....DFYEMFF.DDAVEAAK 50 RTLYIPPSAWATFKPF........EKQFWKIKKDLMDTVVFFQKG....KFYELYE.NDAAIGHQ 51 ----------SAVSPM........MQQYLGIKAQHTDKLVFYRMG....DFYEMFF.DDAVEAAK 52 -----QKYNYNVATKM........MQQYLDIKFAHLDCLLLFRMG....DFYELFY.EDAILASN 53 -----------KLTPM........MQQWHQCKEQAGDCLLLFRLG....EFYEAFF.DDALILAQ 54 KTLHIPPDVFKKMSAS........QKQYWSVKSEYMDIVLFFKVG....KFYELYE.LDAELGHK 55 --LYLPPDFVKKLTGGqvrrahgnLRQWWEFKAKHMDKVVFFKMG....KFYELFE.MDAHVGAK 56 ---------------F........LHFYQSMPEKPDTTVRVFDRN....DYYTVHG.GDALFAAK 57 ------------VTPL........MEQYLRIKEQYKDSILLFRLG....DFYEAFF.EDAKIVSK 58 -----------KLTPM........MQQWHQCKEQAGDCLLLFRLG....EFYEAFF.DDALVLAQ 59 -----------KPTPM........MEQWHQCKEKAGDSVLLFRMG....DFYEAFY.DDAVLLSQ 60 -----------GYTPM........IQQYLKIKAEHQDAFLFFRLG....DFYEMFF.EDAKKASQ 61 ------------VTPL........MEQYLRIKEQYKDSILLFRLG....DFYEAFF.EDAKIVSK 62 KTLWVPPDFHQKQTPG........HRQWWTMKSQHFDTILLFKVG....KFYETYH.MDAVEVVR 63 -----------NVTPM........IRQYLDIKKKYKDAVLFFRVG....SFYEMFF.DDAIEVSK 64 ----ASEESRSTATPM........MEQFIEIKANNPDSLLFYRMG....DFYELFF.QDAVEASR 65 -----------KPTPM........MEQWHQCKEKAGDSVLLFRMG....DFYEAFY.DDAVLLSQ 66 ---------------M........IQQYLKIKAEHQDAFLFFRLG....DFYEMFF.EDAKKASQ 67 ---------------F........VRFFQGMPEKPTTTVRLFDRG....DFYTAHG.EDALLAAR 68 ----KPTKQKSVFTPL........EQQYLELKKNYQETILAIEVG....YKFRFFG.KDAKIASE 69 ------TKQKSVFTPL........EQQYLELKKNYQETILAIEVG....YKFRFFG.KDAKIASE 70 -TLFIPPDALRKMSTS........QKQYWNIKCKYMDVVLFFKVG....KFYELYE.LDAEIGQK 71 -TLFIPPDALRKMSTS........QKQYWNIKCKYMDVVLFFKVG....KFYELYE.LDAEIGQK 72 ----------ASDTPL........MRQYHAIRAQHPDAVLFFRLG....DFYEMFD.SDALHVST 73 --YVPETSSSRKYTPL........EQQVVELKSKYPDVVLMVEVG....YRYRFFG.EDAEIAAR 74 --LSSTEPSKASLPPS........LQYVRDLMDLYKDHVVLTQMG....SFYELYF.EQAIRYAP 75 --LSSTEPSKASLPPS........LQYVRDLMDLYKDHVVLTQMG....SFYELYF.EQAIRYAP 76 -TLHVPEKFLNGLSPG........VRQWWVLKSDNYDCVLFFKVG....KFYELYH.MDADVGVN 77 --------SEKELTPM........LSQYHYFKNQYPDCLLLFRLG....DFYELFY.EDAYIGSK 78 ----YPEYGHKCASNF........IKFHAKLGEKPATTVRFFDHT....DRYTVHGsDDCELVAK 79 --DFIRPKEKVTLPPL........LKEVSFQQKKFADCVLLTKVG....NFYEMYF.EQAEKIGP 80 --------------GF........IRFYKSLPQLGEEAIRIFDRG....DWYTAHG.DDATFIAR 81 ---------------F........IKFHAKLGEKPATTVRFFDHT....DRYTVHGsDDCELVAK 82 ---------------F........IKFHAKLGEKPATTVRFFDHT....DRYTVHGsDDCELVAK 83 ---KARKSPTAKLTPL........DKQVKDLKMHHRDKVLVIRVG....YKYKCFA.EDAVTVSR 84 ---------EKELTPM........LAQYHQFKSMYPDCLLLFRLG....DFYELFY.EDAVVGSK 85 --YVPETSSSRKYTPL........EQQVVELKSKYPDVVLMVEVG....YRYRFFG.EDAEIAAR 86 ---KARKSPTAKLTPL........DKQVKDLKMHHRDKVLVIRVG....YKY-CFA.EDAVTVSR 87 --YVPETSSSRKYTPL........EQQVVELKSKYPDVVLMVEVG....YRYRFFG.EDAEIAAR 88 ----------------........---FYEKMPKDTNTVRVFDRG....EFYVAIG.EDASFVAQ 89 ----------------........---FYEKMPKDTNTVRVFDRG....EFYVAIG.EDASFVAQ 90 ----------------........---FFKKLPQDPRAVRLFDRR....DYYTAHG.ENATFIAR 91 ----------------........---FYKTLPNDTRAVRFFDRK....DYYTAHG.ENSVFIAK 92 ----------------........---FYKTLPNDTRAVRFFDRK....DYYTAHG.ENSVFIAK 93 DCKPFNKRSKSVYTPL........ELQYLDMKQQHKDAVLCVECG....YKYRFFG.EDAEIAAR 94 ----------------........------LKSKSPNTIAIFSRG....EYFSVYG.DDATFVAT 95 ----------------........LQAFTAVGGDDKACVRLFSRGgstpGCYVLGS.WAGFIARE 96 ----------------........---------------------....-------.-------- 97 ----------IKYTPL........EQQVVELKRKHPDVILMVEVG....YRYRFFG.EDAEIAAR 98 ----------------........---------------------....-------.-------- 99 ----------------........---------------------....-------.-------- 100 ----------------........---------------------....-------.-------- 101 ----------------........---------------------....-------.-------- 102 ----------------........---------------------....----CFF.QDAIVVAR 103 ----------------........---------------------....-------.-------- 104 ----------------........---------------------....-------.-------- 105 ----------------........---------------------....-------.-------- 106 -LDFIRPKEKVTLPPL........LKEVSFQQKKFADCVLLTKVG....NFYEMYF.EQAEKIGP 60 70 80 90 1 | | | | 1 ALGL......VLTHK........TSK.DFTTPMAGIPLRAFEAYAER..LL..KMGFRLAVADQV 2 LLDI......SLTKR........GASaGEPIPMAGIPHHAVENYLAK..LV..NQGESVAICEQI 3 LLDI......SLTKR........GASaGEPIPMAGIPHHAVENYLAK..LV..NQGESVAICEQI 4 LLDI......SLTKR........GASaGEPIPMAGIPYHAVENYLAK..LV..NQGESVAICEQI 5 LLDI......SLTKR........GASaGEPIPMAGIPYHAVENYLAK..LV..NQGESVAICEQI 6 LLDI......SLTKR........GQSaGQPIPMAGMPYHAVEGYLAK..LV..QLGESVAICEQI 7 LLDI......SLTKR........GASaGEPIPMAGVPFHAVEGYLAK..LV..QMGESVAICEQI 8 LLDI......SLTKR........SASaGEPIPMAGIPYHAVENYLAK..LV..NQGESVAICEQI 9 LLDI......TLTAR........GQSaGKSIPMAGIPFHSVEGYLAK..LV..KLGESVAICEQI 10 ALGL......VLTHK........TSK.DFTTPMAGIPIRAFDAYAER..LL..RMGFGLAVADQV 11 LLDI......TLTAR........GQSgGKAIPMAGIPFHSAEGYLAK..LV..KLGESVAICEQI 12 LLDI......TLTAR........GQSgGKAIPMAGIPFHSAEGYLAK..LV..KLGESVAICEQI 13 ALGL......VLTHK........TSK.DFTTPMAGIPLRAFEAYAER..LL..KMGFRLAVADQV 14 VLEI......TLTKR........DAKkENPIPMCGVPYHSADSYIDT..LV..NNGYKVAICEQM 15 ELGL......VFMK-........---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQT 16 ELGL......IFMK-........---.-GNWAHSGFPEIAFGRFSDS..LV..QKGYKVARVEQT 17 ELGL......VFMK-........---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQT 18 ELGL......VFMK-........---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQT 19 ELGL......VFMK-........---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQT 20 ELGL......VFMK-........---.-GNWAHSGFPEIAFGRYSDS..LV..QKGYKVARVEQT 21 ILEI......SLTSR........NKNaDNPIPMAGVPYHSAQQYIDV..LI..EQGYKVAIAEQM 22 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 23 ALGL......VLTHK........TSK.DFTTPMAGIPIRAFDAYAER..LL..KMGFRLAVADQV 24 ALGL......VLTHK........TSK.DFTTPMAGIPIRAFDAYAER..LL..KMGFRLAVADQV 25 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 26 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 27 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 28 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 29 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 30 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 31 ELGL......IFMK-........---.-GNWAHSGFPEIAFGRFSDS..LV..QKGYKVARVEQT 32 ELEL......ILTSKeg......GKE.IGRVAMTGVPHHALDRYARQ..LV..EKGYAVAICDQV 33 ELEL......ILTSKeg......GKE.IGRVAMTGVPHHALDRYARQ..LV..EKGYAVAICDQV 34 ELNI......YCHL-........---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQT 35 ELNI......YCHL-........---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQT 36 LFDL......KIAG-........-GG.RANMQLAGIPEMSFEYWAAQ..FI..QMGYKVAKVDQR 37 ELNI......YCHL-........---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQT 38 ALGL......VLTHK........TSK.DFTTPMAGIPIRAFDAYAER..LL..KMGFRLAVADQV 39 ELNI......YCHL-........---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQT 40 LFDL......KIAG-........-GG.RANMQLAGIPEMSFEYWAAQ..FI..QMGYKVAKVDQR 41 ELDI......QYMK-........---.-GEQPHCGFPEKNFSVNIEK..LV..RKGYRVLVVEQT 42 EVFK......TQGVIkymg....PAG.SKTLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNK 43 EVFK......TQGVIkymg....PAG.SKTLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNK 44 EVFK......TQGVIkymg....PAG.AKTLQTVVLSKMNFESFVKDl.LL..VRHYRVEVYKNK 45 ELDW......KMTM-........-SG.VGKCRQVGISESGIDEAVQK..LL..ARGYKVGRIEQL 46 ELNI......YCHL-........---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQT 47 ELNI......YCHL-........---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQT 48 LLDI......TLTQR........GSSgGAPIPMAGVPVHAYEGYLAR..LI..ALGESVAICEQI 49 LLDI......TLTTR........GQVdGEPVKMAGVPFHAAEQYLAR..LV..KLGKSVAICEQV 50 VFSL......KLTDR........---.-VNMKMVGIPEASFDYWASQ..FI..AKGYRIARVDQL 51 LLDI......TLTTR........GQVdGEPVKMAGVPFHAAEQYLAR..LV..KLGKSVAICEQV 52 ILGI......ALTKR........GKNcEEEIPMCGVPYHALEHYLTK..LI..EENYKVAICDQL 53 NLDI......TLTQR........---.-QNVPMSGIPATCLDGYVDR..LV..SRGFKVAIAEQA 54 ELDW......KMTM-........-SG.VGKCRQVGISESGIDEAVQK..LL..ARGYKVGRIEQL 55 ELDI......QYMK-........---.-GEQPHCGFPEKNFSVNIEK..LV..RKGYRVLVVEQT 56 EVFK......TNGVIkyl.....GSG.NKKLESVVLSKMNFESVVKDl.LL..VRQYRVEVYKNK 57 VLNI......VLTRR........---.-QDAPMAGIPYHALNTYLKK..LV..EAGYKVAICDQM 58 NLDI......TLTQR........---.-QNIPMSGIPAAYLDGYVDR..LV..SRGFKIAIAEQA 59 HLEL......TLTQR........---.-QGIPMSGIPVSTVDTYVDR..LI..GKGFKVAVAEQF 60 ELEI......TLTSR........DGGaAEKIPMCGVPYHSASAYIEQ..LI..KKGYKVAICEQT 61 VLNI......VLTRR........---.-QDAPMAGIPYHALNTYLKK..LV..EAGYKVAICDQM 62 ALNI......AFMR-........---.-GSYAHAGFPEHAASKFADQ..LM..NHGYKVARIEQT 63 LLNL......TLTKR........---.-ENVPMCGVPYHTSKEYIRK..LI..LFDKKVAICEQA 64 ALGI......TLTKR........GQHmGQEIPMCGVPVHAADDYLQK..LI..ASGYRVAVCEQV 65 HLEL......TLTQR........---.-QGIPMSGIPVSTVDTYVDR..LI..GKGFKVAVAEQF 66 ELEI......TLTSR........DGGaAEKIPMCGVPYHSASAYIEQ..LI..KKGYKVAICEQT 67 EVFK......TQGVIkymg....PAG.AKNLQSVVLSKMNFESFVKDl.LL..VRQYRVEVYKNR 68 VLGI......SCYF-........---.EHNFLNASVPSYRIDYHLER..LI..NFGLKVAVVRQT 69 VLGI......SCYF-........---.EHNFLNASVPSYRIDYHLER..LI..NFGLKVAVVRQT 70 ELDW......KMTV-........-SG.VGKCRQVGISESGIDDAVDK..LI..ARGYKVGRIEQM 71 ELDW......KMTV-........-SG.VGKCRQVGISESGIDDAVDK..LI..ARGYKVGRIEQM 72 LLGL......TLTKR........---.-NGTPMCGVPVHTARTHIAR..LL..KHGKKVALCEQV 73 VLGI......YAHM-........---.DHNFMTASVPTFRLNFHVRR..LV..NAGYKIGVVKQT 74 ELNI......SLTNR........AYS.HGKVPFAGFPVHQLSRHLKM..LVn.NCGYSVTIAEQF 75 ELNI......SLTNR........AYS.HGKVPFAGFPVHQLSRHLKM..LVn.NCGYSVTIAEQF 76 ELGF......TYMR-........---.-GEFAHSGFPEISFDKMSTI..LV..DRGFKVARVEQT 77 ELGL......VLTSRpa......GKG.KERIPMCGVPYHSANSYIAK..LV..NKGYKVAICEQV 78 IVYK......STAFIgallp...DDK.KETLQFVSMSKGNFELAVREl.LL..VRNYRVEVY--- 79 LLNL......RVSKK........KTS.KSDVSMAGFPFFKLDRYLKI..LVe.DLKKCVALSEEV 80 TVYK......TTSVIrqlg....RSD.HTGLPSVTMTVTVFRQFLREa.LF..KLGKRIEIW--- 81 IVYK......STAFIgallp...DDK.KETLQFVSMSKGNFELAVREl.LL..VRNYRVEVY--- 82 IVYK......STAFIgallp...DDK.KETLQFVSMSKGNFELAVREl.LL..VRNYRVEVY--- 83 ILHI......KLVPGklt10npqDCN.HRQFAYCSFPDVRLNVHLER..LV..HHNLKVAVVEQA 84 ELGL......VLTSRpa......GKG.RERIPMCGVPYHSANNYIAK..LV..NKGYKVAICEQV 85 VLGI......YAHM-........---.DHNFMTA-------------..--..--GYKIGVVKQT 86 ILHI......KLVPGklt10npqDCN.HRQFAYCSFPDVRLNVHLER..LV..HHNLKVAVVEQA 87 VLGI......YAHM-........---.DHNFMTA-------------..--..--RYKIGVVKQT 88 NAYH......TTSVLk.......HHN.VSNTSYCNLSPSLFIKFAEDv.LS..NLAKRVEIW--- 89 NAYH......TTSVLk.......HHN.VSNTSYCNLSPSLFIKFAEDv.LS..NLAKRVEIW--- 90 TYYH......TMSALrql.....GSS.SDGILSASVSKAMFETIARNilLE..RTDCTLELYEGS 91 TYYH......TTTALrql.....GSG.SNALSSVSISRNMFETIARD..LLleRNDHTVELYEGS 92 TYYH......TTTALrql.....GSG.SNALSSVSISRNMFETIARD..LLleRNDHTVELYEGS 93 ELNI......YCHL-........---.DHNFMTASIPTHRLFVHVRR..LV..AKGYKVGVVKQT 94 NIFKsdvcvkTFTLS........TDN.SQQMKYISVNRGQYEKVVREt.IV..LLRCSVELY--- 95 YIRS......TAVL-........-KN.WGGVDVVVVNDSIAKEVIRDc.LL..RRGASVEYYERP 96 ----......-----........---.--------------------..--..------------ 97 VLGI......YAHM-........---.DHSFMTASVPTFRLNVHVRG..LV..NAGYKVGVVKQT 98 ----......-----........---.--------------------..--..------------ 99 ----......-----........---.--------------------..--..------------ 100 ----......-----........---.--------------------..--..------------ 101 ----......-----........---.--------------------..--..------------ 102 ELEL......VLTSKea......GKE.VGRVPMAGIPYHALDRYASQ..LV..EKGYAIAICDQV 103 ----......-----........---.--------------------..--..------------ 104 ----......-----........---.--------------------..--..------------ 105 ----......-----........---.--------------------..--..------------ 106 LLNL......RVSKK........KTS.KSDVSMAGFPFFKLDRYLKI..LVe.DLKKCVALSEEV 00 110 120 130 | | | | 1 EPA...EEAE........GLVRREVTQLLTPGTLLQ..ESLLP........RE.ANYLAAIAT.. 2 GDP...ATSK........GPVERKVVRIVTPGTISD..EALLQe.......RQ.DNLLAAIWQd. 3 GDP...ATSK........GPVERKVVRIVTPGTISD..EALLQe.......RQ.DNLLAAIWQd. 4 GDP...ATSK........GPVERKVVRIVTPGTISD..EALLQe.......RQ.DNLLAAIWQd. 5 GDP...ATSK........GPVERKVVRIVTPGTISD..EALLQe.......RQ.DNLLAAIWQd. 6 GDP...TTSK........GPVERQIVRIVTPGTVSD..EALLPe.......RQ.DNLIAAVYQe. 7 GDP...ATSK........GPVERKVVRIVTPGTVTD..EALLSe.......RV.DNLIAAIYHh. 8 GDP...ATSK........GPVERKVVRIVTPGTISD..EALLQe.......RQ.DNLLAAIWQd. 9 GDP...ATTK........GPVERQVVRIITPGTVSD..EALLDe.......RR.DNLLAAVVGd. 10 EPA...EEAE........GLVRREVTQLLTPGTLTQ..EALLP........RE.ANYLAAIAT.. 11 GDP...ATSK........GPVERQVVRIITPGTVSD..EALLDe.......RR.DNLLAAILGd. 12 GDP...ATSK........GPVERQVVRIITPGTVSD..EALLDe.......RR.DNLLAAILGd. 13 EPA...EEAE........GLVRREVTQLLTPGTLLQ..ESLLP........RE.ANYLAAIAT.. 14 EDP...KQTK........GMVRREVVRIVTPGTVMEq.GGVDD........KQ.NNYILSFVMn. 15 ETP...EMMEarc13kydRVVRREICRIITKGTQTY..SVLEGdpse....NY.SKYLLSLKEke 16 ETP...EMMEarc13kfdRVVRREICRIITKGTQTY..SVLDGdpse....NY.SRYLLSLKEke 17 ETP...EMMEarc13kydRVVRREICRIITKGTQTY..SVLEGdpse....NY.SKYLLSLKEke 18 ETP...EMMEarc13kydRVVRREICRIITKGTQTY..SVLEGdpse....NY.SKYLLSLKEke 19 ETP...EMMEarc13kydRVVRREICRIITKGTQTY..SVLEGdpse....NY.SKYLLSLKEke 20 ETP...EMMEarc13kydRVVRREICRIITKGTQTY..SVLEGdpse....NY.SKYLLSLKEke 21 EDP...KQAV........GVVKREVVQVITPGTVVD..SSKPD........SQ.NNFLVSIDRe. 22 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 23 EPA...EEAE........GLVRREVTQLLTPGTLTQ..EALLP........RE.ANYLAAIAT.. 24 EPA...EEAE........GLVRREVTQLLTPGTLTQ..EALLP........RE.ANYLAAIAT.. 25 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 26 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 27 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 28 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 29 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 30 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 31 ETP...EMMEarc13kfdRVVRREICRIITKGTQTY..SVLDGdpse....NY.SRYLLSLKEke 32 EDA...AEAQaek.....RMVERQVTKLLTPGTLTD..DSMLPa.......KR.NNFLAAIAMv. 33 EDA...AEAQaek.....RMVERQVTKLLTPGTLTD..DSMLPa.......KR.NNFLAAIAMv. 34 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG..EDVNPlir16mtdTS.TNYLLCIYEek 35 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG..EDVNPlir16mtdTS.TNYLLCIYEek 36 ESM...LAKEmregsk..GIVKRELQCILTSGTLTD..GDMLH........SDlATFCLAIREep 37 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG..EDVNPlir16mtdTS.TNYLLCIYEek 38 EPA...EEAE........GLVRREVTQLLTPGTLTQ..EALLP........RE.ANYLAAIAT.. 39 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG..EDVNPlir16mtdTS.TNYLLCIYEek 40 ESM...LAKEmregsk..GIVKRELQCILTSGTLTD..GDMLH........SDlATFCLAIREep 41 ETP...DQLEqrr10skdKVVKREVCAVVTKGTLTD..GEMLLtn......PD.ASYLMALTEgg 42 AGN...KASK........E-NEWYLAFKASPGNLSQf.EDILF........GN.NDMSASVGVmg 43 AGN...KASK........E-NEWYLAFKASPGNLSQf.EDILF........GN.NDMSASVGVmg 44 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMATSIGImg 45 ETS...DQAKargan...TIIPRKLVQVLTPSTASE..GNIGP........DA.V-HLLAIKEik 46 ETA...ALKAigdnrs..SLFSRKLTALYTKSTLIG..EDVNPlik16mtdTS.TSYLLCISEnk 47 ETA...ALKAigdnrs..SLFSRKLTALYTKSTLIG..EDVNPlik16mtdTS.TSYLLCISEnk 48 GDP...GLAK........GLVERKVVRIVTPGTITD..EVLLEe.......RR.DTLLMALSRs. 49 GEV...GAGK........GPVERKVVRIVTPGTLTD..SALLEd.......KE.TNRIVAVSPd. 50 ETA...LGKEikd11keeKVVQRGLTQVLTSGTLVD..EAMLT........SDlSTYCMAIKEsl 51 GEV...GAGK........GPVERKVVRIVTPGTLTD..SALLEd.......KE.TNRIVAVSPd. 52 ETP...EEAKkrdgyk..AVVTRDVTRIITPGTIIE..ENLISv.......TE.PNYLTSLVIpk 53 DNT...EGSK........GLVPRTINRLITPGALLS..SSLLPe.......KA.NNYVLAINQv. 54 ETS...DQAKargan...TIIPRKLVQVLTPSTASE..GNIGP........DA.V-HLLAIKEik 55 ETP...DQLEqrr10skdKVVKREVCAVVTKGTLTD..GEMLLtn......PD.ASYLMALTEgg 56 SGG...KYSK........E-NDWQLAFKASPGNLTQf.EEILF........GN.NDMSTAVGVvg 57 EEP...SKSK........KLIRREVTRVVTPGSIVE..DEFLS........ET.NNYMAVVSEe. 58 DNS...EGGK........GLVPRTINRLITPGALLS..SSLLPe.......KA.NNYIIAISQv. 59 GEP...AKEKeskki...GPMARDIQRFVTPGTLLS..STLLQe.......KF.NNYIVAINRi. 60 EDP...KAAK........GVVKREVVQLITPGTVMDg.KGIHE........SE.NNFIASVSAc. 61 EEP...SKSK........KLIRREVTRVVTPGSIVE..DEFLS........ET.NNYMAVVSEe. 62 ETP...QMLEern10tkeKVVRREVCRVTSNGTRTY..GVLDGvdl11tldPT.AKHLLAIKEfh 63 SN-...STSG........GPLEREVVEVITPGVIID..EDFLN........DDiNNYLVAISDy. 64 EDP...AEAKkrgsk...SVVRRDVVRLVTPGTITE..DKLLSp.......SE.SNYLMALARir 65 GEP...AKEKeskki...GPMARDIQRFVTPGTLLS..STLLQe.......KF.NNYIVAINRi. 66 EDP...KAAK........GVVKREVVQLITPGTVMDg.KGIHE........SE.NNFIASVSAc. 67 AGN...KASK........E-NDWYLAYKASPGNLSQf.EDILF........GN.NDMSASIGVvg 68 ETA...ALKStsssrn..TLFDRRVARVLTKGTTLD..DSFFRfeq9hgtlQA.SQFILCVADnv 69 ETA...ALKStsssrn..TLFDRRVARVLTKGTTLD..DSFFRfeq9hgtlQA.SQFILCVADnv 70 ESA...NQAKargvh...SVIERKLVHVSTPSTAVDn.---IG........TD.AVHLLALKEvt 71 ESA...NQAKargvh...SVIERKLVHVSTPSTAVDn.---IG........TD.AVHLLALKEvt 72 SHP...V-PG........ELTQRKVIEIISPGTAVE..DDFLSq.......GF.SQYLATVCAs. 73 ETA...AIKShganrt..GPFFRGLSALYTKATLEAa.EDISGgcg9egfgSQ.SNFLVCVVDer 74 KKK...DVADnea.....NKFYRRVTRIVTPGTFID..EAFENl.......RE.NTYLLNIEFpe 75 KKK...DVADnea.....NKFYRRVTRIVTPGTFID..EAFENl.......RE.NTYLLNIEFpe 76 ETP...DMMTerc12kfdKVVAREICQITNRGTQVF..GSQCKigpn....HQ.PNYMLAIVEkd 77 EDP...SKAK........GIVKREVVRVITPGTFFE..-----........RD.TGGLASLYKk. 78 ---...--VK........NSSDWEIEYRGSPGNLLQf.EDILF........SN.KEVLVGNSIis 79 IRPvddLSSK........NMYIRSVTRVITPGTLID..ENFMNp.......YE.SNYILTVVFdp 80 ---...ASPS........GRMNWKVVKQASPGNLQDv.EDELGgqf.....EG.APVILAVKIsa 81 ---...--VK........NSSDWEIEYRGSPGNLLQf.EDILF........SN.KEVLVGNSIis 82 ---...--VK........NSSDWEIEYRGSPGNLLQf.EDILF........SN.KEVLVGNSIis 83 ETS...AIKKhdpgasksSVFERKISNVFTKATFGV..NSTFVlrgkril.GD.TNSIWALSRdv 84 EDP...SKAK........GIVKRDVIRVITPGTFFE..-----........RE.TGGLCSLYRk. 85 ETA...AIKShganrt..GPFFRGLSALYTKATLEAa.EDISGgcg9egfgSQ.SNFLVCVVDer 86 ETS...AIKKhdpgasksSVFERKISNVFTKATFGV..NSTFVlrgkril.GD.TNSIWALSRdv 87 ETA...AIKShganrt..GPFFRGLSALYTKATLEAa.EDISGgcg9egfgSQ.SNFLVCVVDer 88 ---...GANS........AKTGFELLKQASPGNMQMl.EDLLVsen13sdsSV.SSVLLAVTTrv 89 ---...GANS........AKTGFELLKQASPGNMQMl.EDLLVsen13sdsSV.SSVLLAVTTrv 90 GS-...----........---NWRLTKSGTPGNIGSf.EDILFanndm...ED.SPVIVALFPac 91 GS-...----........---NWRLVKTGSPGNIGSf.EDVLFannem...QD.TPVVVSIFPsf 92 GS-...----........---NWRLVKTGSPGNIGSf.EDVLFannem...QD.TPVVVSIFPsf 93 ETA...ALKAigdnks..SVFSRKLTALYTKSTLIG..EDVNPlir16mtdTS.TNYLLCIYEek 94 ---...--SS........EQGEWKMTKRGSPGNTVDfeQEIGV........SD.QAPILAIYIhp 95 PGG...G---........---TYACVQRGSPGNITDf.EATLF........SF.EEAEIQLMAtg 96 ---...----........------VTRVITPGTLID..ENFMNp.......YE.SNYILTVVFdp 97 ETA...AIKShganra..GPFFRGLSGLYTKATLEAa.EDISGgcv9egfgGQ.SNFLVCVVDer 98 ---...----........------------------..-----........SI.DCVLCCIYEvp 99 ---...----........------------------..-----........SI.DCVLCCIYEvp 100 ---...----........------------------..---SA........HS.PSVIVAVVEgr 101 ---...----........------------------..---SA........HS.PSVIVAVVEgr 102 ETA...AQAQg.......PLVRREITRIITPGTILE..EGMLQa.......RR.NNFLAAVVIa. 103 ---...----........------------------..-----........--.---------.. 104 ---...----........------------------..-----........--.---------.. 105 ---...----........------------------..-----........--.---------.. 106 IRPvddLSSK........NMYIRSVTRVITPGTLID..ENFMNp.......YE.SNYILTVVF.. 140 150 160 170 180 19 | | | | | 1 ......GDGWGLAFLDVSTGEFKGTVLKS....KSALYDELFRHRPAEVLL.....APELLENGA 2 ......GKGYGYATLDISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMAL 3 ......GKGYGYATLDISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMAL 4 ......SKGFGYATLDISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMSL 5 ......SKGFGYATLDISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMSL 6 ......KEKFGLATLDMTSGRFQLCEPAD....KETLRAELQRIAPVELLY.....CEEFNEMAA 7 ......NGRFGYATMDITSGRFQLSEPQT....EEEMAAELQRTSPRELLF.....PEDFSPVHL 8 ......SKGFAYATLDISSGRFRLSEPAD....RETMAAELQRTNPAELLY.....AEDFAEMSL 9 ......ERLFGLAILDITSGRFNVQEIQG....WENLLAELERLNPAELLY.....PDDWPAGLP 10 ......GDGWGLAFLDVSTGEFKATLLKS....KSALYDELFRHRPAEVLL.....APELRENEA 11 ......ERLFGLAVLDITSGRFSVQEIKG....WETLLAELERLNPAELLI.....PDDWPQGLP 12 ......ERLFGLAVLDITSGRFSVQEIKG....WETLLAELERLNPAELLI.....PDDWPQGLP 13 ......GDGWGLAFLDVSTGEFKGTVLKS....KSALYDELFRHRPAEVLL.....APELLENGA 14 ......QPEIALSYCDVSTGELKVTHFND....EATLLNEITTINPNEVVI.....NDNISDNLK 15 edssghTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKET 16 eetsghTRVYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQILF.....EKGNLSTET 17 edssghTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKET 18 edssghTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKET 19 edssghTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKET 20 edssghTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQVLF.....EKGNLSKET 21 ......GNQFGLAYMDLVTGDFYVTGLLD....FTLVCGEIRNLKAREVVL.....GYDLSEEEE 22 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 23 ......GDGWGLAFLDVSTGEFKGTLLKS....KSALYDELFRHRPAEVLL.....APELRENEA 24 ......GDGWGLAFLDVSTGEFKGTLLKS....KSALYDELFRHRPAEVLL.....APELRENEA 25 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 26 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 27 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 28 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 29 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 30 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 31 eetsghTRVYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTLVAHYPPVQILF.....EKGNLSTET 32 ......EDKWGLAHADISTGEFFTCQSSN....LDDLAVELLRLQPSEVLI.....PTSAPDIRN 33 ......EDKWGLAHADISTGEFFTCQSSN....LDDLAVELLRLQPSEVLI.....PTSAPDIRN 34 e11kkgNLSVGVVGVQPATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTE 35 e11kkgNLSVGVVGVQPATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTE 36 g21klnTKIFGAAFIDTATGELQMLEFEDdse.CTKLDTLMSQVRPMEVVM.....ERNNLSTLA 37 e11kkgNLSVGVVGVQPATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTE 38 ......GDGWGLAFLDVSTGEFKGTLLKS....KSALYDELFRHRPAEVLL.....APELRENEA 39 e11kkgNLSVGVVGVQPATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTE 40 g21klnTKIFGAAFIDTATGELQMLEFEDdse.CTKLDTLMSQVRPMEVVM.....ERNNLSTLA 41 e10ptaEHNFGVCLVDVATQKIILGQFKDdqd.CSALSCLLSEMRPVEIIK.....PAKVLSYAT 42 i10vdgQRHVGVGYVDSTQRKLGLCEFPEndq.FSNLEALLIQIGPKECVLp....GGETTGDMG 43 i10vdgQRHVGVGYVDSTQRKLGLCEFPEndq.FSNLEALLIQIGPKECVLp....GGETTGDMG 44 i10vdgQRQVGVGDVDSTQRKLGLCEFPDndq.FSNLEALLIQIGPKECILp....GGETAGDMG 45 melqkcSTVYGFAFVDCAALRFWVGSISDdas.CAALGALLMQVSPKEVLY.....DSKGLSREA 46 e11kkgNIFIGIVGVQPATGEVVFDSFQDsas.RSELETRMSSLQPVELLL.....PSALSEQTE 47 e11kkgNIFIGIVGVQPATGEVVFDSFQDsas.RSELETRMSSLQPVELLL.....PSALSEQTE 48 ......KNCYGLAWADLAGGRFLVNEVNS....EEALEAELARLEPAELLLp....DEDAWPEYL 49 ......KKYIGLAWASLQSGEFKTKLTT-....VDKLDDELARLQAAEILL.....PDSKNAPQL 50 qsdne.EPSFGICFIDTSTGGFHMCEFTDdih.RTKLDTLLTQVRPKELIL.....EKSKISQKS 51 ......KKYIGLAWASLQSGEFKTKLTT-....VDKLDDELARLQAAEILL.....PDSKNAPQL 52 n.....KKTASICCVDLSTSKIFVINVP-....ETEILNELARLKSREILL.....SENLKSSNI 53 ......GSLYGLSCLDLSIGTFLVAEYDN....TKDLIEAICRLAPTELLS.....HAKFYQKNE 54 melqkcSTVYGFAFVDCAALRFWVGSISDdas.CAALGALLMQVSPKEVLY.....DSKGLSREA 55 e10ptaEHNFGVCLVDVATQKIILGQFKDdqd.CSALSCLLSEMRPVEIIK.....PAKVLSYAT 56 i10segQRLVGVGYVDSTLRKLGVCEFPDndq.FSNLEALLVQIGPKECVMp....GGETAGDMG 57 ......KGRYCTVFCDVSTGEVLVHESSD....EQETLDLLKNYSISQIIC.....PEHLKSSLK 58 ......GSLYGLSCLDLSTGTFLVAEYDN....TKDLIEAVYRLAPTELLS.....HAKFYQKNE 59 ......GSLFGFACLDLSTGSFFIEECEN....TKELVDEICRLAPSEVLS.....CNKFYNKET 60 ......SNGYGLALSDLTTGENLAVLIER....LEDVISEIYSVGAREIVV.....SGSLDADTV 61 ......KGRYCTVFCDVSTGEVLVHESSD....EQETLDLLKNYSISQIIC.....PEHLKSSLK 62 npetg.KSSYGVCMIDTTTAHIRIGQFEDddy.RSQLRTLLANVIVVQAIV.....ERGSISSTT 63 ......KDYYSFSYIDLSTSSLGIMFYENgf..FEKLKRDLEKYSPKEIIV.....SENFYYEYS 64 sgs...EPAYALAWIDISTGIFRLAETA-....ESRLLADILRIEPRELIL.....PDTVFHDPD 65 ......GSLFGFACLDLSTGSFFIEECEN....TKELVDEICRLAPSEVLS.....CNKFYNKET 66 ......SNGYGLALSDLTTGENLAVLIER....LEDVISEIYSVGAREIVV.....SGSLDADTV 67 v10vdgQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEALLIQIGPKECVLp....GGETAGDMG 68 d10ksgRVQVGLIAIQLSSGTTVYDHFQDdfl.RSELQTRLSHFQPCELIY.....SNKLSSESV 69 d10ksgRVQVGLIAIQLSSGTTVYDHFQDdfl.RSELQTRLSHFQPCELIY.....SNKLSSESV 70 lassg.FQVFGFAFLDYAALKIWVGSVQDdds.SAALGALLMQVSPRELIY.....ETSGISKET 71 lassg.FQVFGFAFLDYAALKIWVGSVQDdds.SAALGALLMQVSPRELIY.....ETSGISKET 72 ......DATVAFSYLEVSTGAFFITSFPRaea.ADALQKEFGRVQPSEVLL.....SASVLRSLP 73 v16msfDVRVGVVGVEISTGEVVYEEFNDnfm.RSGLEAVILSLSPAELLL.....GQPLSQQTE 74 n11adtSLKVGICWCDVSTGEIFVQQVY-....LRDLVSAITRIQPKEILL.....DERLLEFHI 75 n11adtSLKVGICWCDVSTGEIFVQQVY-....LRDLVSAITRIQPKEILL.....DERLLEFHI 76 egt...CSRYGVCFIDTSIGDFHLGEFEDdkn.CSRLLTLVSHHMPVLFLN.....EKSALSQRT 77 ......GNHYYVGYLNLAVGEFLGAKVK-....IEELLDLLSKLNIKEILVk....KGEKLPEEL 78 l11gggQRRVGVASVEQNDCKFQLLEFLDddf.FTELEATVVLLGPKECLL.....P-SIEGEYS 79 n22cfaDCKIGLSWLDLSTGEFFTQDSN-....LQRLAGDLTRISPREIVL.....DESLKSFTT 80 kase..ARTVGVCFADASVRELGVSEFLDndl.YSNFEALLIQLGVKECIVtqdkgEKEKDPELA 81 l11gggQRRVGVASVEQNDCKFQLLEFLDddf.FTELEATVVLLGPKECLL.....P-SIEGEYS 82 l11gggQRRVGVASVEQNDCKFQLLEFLDddf.FTELEATVVLLGPKECLL.....P-SIEGEYS 83 hqgk..VAKYSLISVNLNNGEVVYDEFEEpnlaDEKLQIRIKYLQPIEVLV.....NTDDLPLHV 84 ......GKSYLVSYLNLSVGEFIGAKVK-....EEELIDFLSKFNIREVLVk....KGEKLPEKL 85 v16msfDVRVGVVGVEISTGEVVYEEFNDnfm.RSGLEAVILSLSPAELLL.....GQPLSQQTE 86 hqgk..VAKYSLISVNLNNGEVVYDEFEEpnlaDEKLQIRIKYLQPIEVLV.....NTDDLPLHV 87 v16msfDVRVGVVGVEISTGEVVYEEFNDnfm.RSGLEAVILSLSPAELLL.....GQPLSQQTE 88 kqd...QRIIGVAFIDPILKKLGVSEFVDsda.YTNFEALIVQVGAKECII.....SQSGHESTN 89 kqd...QRIIGVAFIDPILKKLGVSEFVDsda.YTNFEALIVQVGAKECII.....SQSGHESTN 90 res...QLYVGLSFLDMTNRKLGLAEFPEdsr.FTNVESALVALGCKECLL.....PADCEKSID 91 hdg...RCVIGMAYVDLTRRVLGLAEFLDdsr.FTNLESSLIALGAKECIFpa...ESGKSNECK 92 hdg...RCVIGMAYVDLTRRVLGLAEFLDdsr.FTNLESSLIALGAKECIFpa...ESGKSNECK 93 e11kkgNLSVGVVGVQPATGEVVFDCFQDsas.RLELETRISSLQPVELLL.....PSDLSEPTE 94 gdd...DNRVTLCAWDAGNVRIVISEYIDtps.FSQTEQCIFGLCPTEYILvn...EGSVAPKAK 95 a24ggqGIRVGFAALNTTLRTLTYAEYLDtlq.LTSLDALMAQCNLKELIYl....DKSRCRGGS 96 n22cfaDCKIGLSWLDLSTGEFFTQDSN-....LQRLAGDLTRISPREIVL.....DESLKSFTT 97 v17asfDVRVGVVGVEISTGEVVHGEFNDnfm.RSGLEAVIL---------.....--------- 98 rdi...STRIGLCIINCNTGQMYLSDFMDsqi.YIRVVHKLQIYQPTEILI.....PSSSLAPTV 99 rdi...STRIGLCIINCNTGQMYLSDFMDsqi.YIRVVHKLQIYQPTEILI.....PSSSLAPTV 100 gla...RGEIGMASIDLKNPQIILSQFADntt.YAKVITKLKILSPLEIIM.....SNTACAVGN 101 gla...RGEIGMASIDLKNPQIILSQFADntt.YAKVITKLKILSPLEIIM.....SNTACAVGN 102 ......GEHWGLAYADSSTGDYWTSQSTG....LEGL--------------.....--------- 103 ......----------------KLNKLPNn...FFRMSRAIERLKAMAGSH.....DSSMTEEDK 104 ......----------------KLNKLPNn...FFRMSRAIERLKAMAGSH.....DSSMTEEDK 105 ......----------------KLNKLPNn...FFRMSRAIERLKAMAGSH.....DSSMTEEDK 106 ......-----------------------....------------------.....--------- 0 200 210 220 230 2 | | | | | 1 FLDEFRKRFPVMLSEA........PFEPEGEGPLALRRARGALLAYAQRTQGGAL........SL 2 IEGRRGLRRRPLWEFEidt16trdLVGFGVENASRGLCAAGCLLQYVKDTQRTSLp.......HI 3 IEGRRGLRRRPLWEFEidt16trdLVGFGVENASRGLCAAGCLLQYVKDTQRTSLp.......HI 4 IEGRRGLRRRPLWEFEidt16trdLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLp.......HI 5 IEGRRGLRRRPLWEFEidt16trdLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLp.......HI 6 IEHCKGLRRRPIWEFElst16tkdLRAFGVEKSPLGLSAAGCLLQYAKETQRTALp.......HI 7 MASRQGNRRRPIWEFEldt16trdLVGFGVEQAKLGLCAAGCLIQYVKDTQRTALp.......HI 8 IEGRRGLRRRPLWEFEidt16trdLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLp.......HI 9 LEKRRGAHRRAPWDFDfds16tqdLKGFGCDGLGLAIGAAGCLLAYARETQRTALp.......HL 10 FVAQFRKRFPVMLSEA........PFDPEGEAPLALSRARGALLAYARATQGGAL........SV 11 AEKRRGVRRRAPWDFDrds16tqdLKGFGCQNLTLAIGAAGCLLAYAKETQRTALp.......HL 12 AEKRRGVRRRAPWDFDrds16tqdLKGFGCQNLTLAIGAAGCLLAYAKETQRTALp.......HL 13 FLDEFRKRFPVMLSEA........PFEPEGEGPLALRRARGALLAYAQRTQGGAL........SL 14 RQINMVTETITVRETLsse.....IYSVNQTEHKLMYQATQLLLDYIHHTQKRDLs.......HI 15 KTILKSSLSCSLQEGLipg47sdsIGLTPGEKSELALSALGGCVFYLKKCLIDQE........LL 16 KTVLKGSLSSCLQEGLipg45sdsVGLTPGEESELALSALGGIVFYLKKCLIDQE........LL 17 KTILKSSLSCSLQEGLipg47sdsIGLTPGEKSELALSALGGCVFYLKKCLIDQE........LL 18 KTILKSSLSCSLQEGLipg47sdsIGLTPGEKSELALSALGGCVFYLKKCLIDQE........LL 19 KTILKSSLSCSLQEGLipg47sdsIGLTPGEKSELALSALGGCVFYLKKCLIDQE........LL 20 KTILKSSLSCSLQEGLipg47sdsIGLTPGEKSELALSALGGCVFYLKKCLIDQE........LL 21 QILSRQMNLVLSYEKEsfed....LHLLDLRLATVEQTASSKLLQYVHRTQMRELn.......HL 22 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 23 FVAEFRKRFPVMLSEA........PFEPQGEGPLALRRAQGALLAYARATQGGAL........SV 24 FVAEFRKRFPVMLSEA........PFEPQGEGPLALRRAQGALLAYARATQGGAL........SV 25 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 26 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 27 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 28 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 29 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 30 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 31 KTVLKGSLSSCLQEGLipg45sdsVGLTPGEESELALSALGGIVFYLKKCLIDQE........LL 32 ILRPGEPSEHIPKQLPtsf30vksLEGMGCEGLPLAIRAAGGLLEYIEDTQKAHVv.......PI 33 ILRPGEPSEHIPKQLPtsf30vksLEGMGCEGLPLAIRAAGGLLEYIEDTQKAHVv.......PI 34 MLIQRATNVSVRDDRIrve34gsqSLSGVINLEKPVICALAAVIRYLKEFNLEKM........LS 35 MLIQRATNVSVRDDRIrve34gsqSLSGVINLEKPVICALAAVIRYLKEFNLEKM........LS 36 NKIVKFNSAPNAIFNEvka32pevLKSYYDTGKKVGFSAFGGLLYYLKWLKLDKN........LI 37 MLIQRATNVSVRDDRIrve34gsqSLSGVINLEKPVICALAAVIRYLKEFNLEKM........LS 38 FVAEFRKRFPVMLSEA........PFEPQGEGPLALRRAQGALLAYARATQGGAL........SV 39 MLIQRATNVRLKTVRKlkt55gsqSLSGVINLEKPVICALAAVIRYLKEFNLEKM........LS 40 NKIVKFNSAPNAIFNEvka32pevLKSYYDTGKKVGFSAFGGLLYYLKWLKLDKN........LI 41 ERTIVRQTRNPLVNNLvpl50mlsELATEDKNGSLALSALGGAIYYLRQAFLDES........LL 42 KLRQVIQRGGILITERkra27qinSAALPEMENQVAVSSLSAVIKFLELLSDDSN........FG 43 KLRQVIQRGGILITERkra27qinSAALPEMENQVAVSSLSAVIKFLELLSDDSN........FG 44 KLRQVIQRGGILITERkri27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 45 QKALRKYTLTGSTAVQlap34swnCAVDGLNECDVALSALGELINHLSRLKLEDVlk......HG 46 ALIHRATSVSVQDDRIrve34gsqIISGIVNLEKPVICSLAAIIKYLKEFNLEKM........LS 47 ALIHRATSVSVQDDRIrve34gsqIISGIVNLEKPVICSLAAIIKYLKEFNLEKM........LS 48 QQRNGVRRRPPWLFDAdsg15lhdLSGFGIENNPQATAAAGALLGYIEETQKQRLp.......HL 49 QTASGVTRLNAWQFAAdag17dlrGFGLDGKEHAVAIGAAGALLNYIRLTQNLMPq.......HL 50 IRAIKYCVSSSSIWNFikp32apkILKSYLSEKPLAISAFGALFWYLRQLKLDKD........MC 51 QTASGVTRLNAWQFAAdag17dlrGFGLDGKEHAVAIGAAGALLNYIRLTQNLMPq.......HL 52 SDSI-LKQFNCRITYQvds21kirDIKGIGEISNSQICAIGSILEYLSLTQKQNIp.......HL 53 AVIKQLQQHLRITLSEyvs23vssLDGFGLQGLVPAINAAGALLSYIQDKLLLPIs.......HL 54 QKALRKYTLTGSTAVQlap34swnCAVDGLNECDVALSALGELINHLSRLKLEDVlk......HG 55 ERTIVRQTRNPLVNNLvpl50mlsELATEDKNGSLALSALGGAIYYLRQAFLDES........LL 56 KLRQIVKRGGILITDRkra27qvtSAALPEMEKQVAMSALAAVMKYLELLSDESN........FG 57 ERFPGVYTETISEWYFsdl12ynlKDIHHFELSPLALKALAALIKYVKYTMIAEDl.......NL 58 PVVKQLQQHLRITLSEhvs23vssLDGFGLQGLVPAINAAGALLSYIQDKLLLPIs.......HL 59 AIVMQLQQHLKLTLSTyad23vasLDGFGLKGLVPAINAAGGLLSYIQDKLLLPTk.......HI 60 AQLRERCGATISIEDGetdeh...VTIIEHLNNEDITKTFLRLYTYLKRTQKRSLd.......HL 61 ERFPGVYTETISEWYFsdl12ynlKDIHHFELSPLALKALAALIKYVKYTMIGEDl.......NL 62 KSIINGILFSVPVEHLlpk41dssILPKPSTDWQLALSAFGAIFWYLRDSLIDVD........ML 63 EKLNLSRFLINRVPTWhld19ilgLSSLGFDEEKPYYISIFLIINHIKNNLKNLLs.......NI 64 LRPVFDVLGRVAVPQPavl20gvgTLDGFGSFSRAELAAASAAVSYVEKTQLQERp.......AL 65 AIVMQLQQHLKLTLSTyad23vasLDGFGLKGLVPAINAAGGLLSYIQDKLLLPTk.......HI 66 AQLRERCGATISIEDGetdeh...VTIIEHLNNEDITKTFLRLYTYLKRTQKRSLd.......HL 67 KLRQIIQRGGILITERkka27qmnSAVLPEMENQVAVSSLSAVIKFLELLSDDSN........FG 68 ALLNHYVSTEKTCGRVvrv36ielHMEKVKSLHSLSIICLDMAISYLMEFSLEDL........FV 69 ALLNHYVSTEKTCGRVvrv36ielHMEKVKSLHSLSIICLDMAISYLMEFSLEDL........FV 70 QRTIRKYASAGSVKMQltp33swlSALDCTMNQDVVICALGGLIGHLTRLMLHDAlk......NG 71 QRTIRKYASAGSVKMQltp33swlSALDCTMNQDVVICALGGLIGHLTRLMLHDAlk......NG 72 ELAAILSLYPRLVRTTgad23trnLDCLTLLPHSPDLAAAGALIAYLEETTRHPLs.......HV 73 KFLVAHAGPTSNVRVEras46sclTVHTIMNMPHLTVQALALTFCHLKQFGFERI........LY 74 ESGTWYPELVELKKFFiky31erqLKIQFQTFTQKELAALRNTLIYVSNHLPDFSi.......NF 75 ESGTWYPELVELKKFFiky31erqLKIQFQTFTQKELAALRNTLIYVSNHLPDFSi.......NF 76 QQIVRTVLGGILKEPVpgn44mdhLGLTPNDNYKLALKALGQCIFFIHKCKLEPK........VL 77 EKVLKVYVSELEEEFFeeg14gvlSLQAFGFEEDTYSLPLGAVYKYAKTTQKGYT........PL 78 AVKTLLDRNGVMITMPkks25qedATGLKELQLQLASNALKTAIKYLDLVNDAGN........LG 79 HPIYSFIQERKYFLSYven19keiDPSFIKYCTKLEVTAGCTLISYIADRLQNSHp.......NI 80 KLRQIIDNCGVAIAERsag23eraASLLPQTDLKLAMGSASALIKYLGILHDPSN........FG 81 AVKTLLDRNGVMITMPkks25qedATGLKELQLQLASNALKTAIKYLDLVNDAGN........LG 82 AVKTLLDRNGVMITMPkks25qedATGLKELQLQLASNALKTAIKYLDLVNDAGN........LG 83 AKFFKDISCPLIHKQEydl12aikVMNEKIQLSPSLIRLVSKLYSHMVEYNNEQV........ML 84 EKVLKLHITELEEEFFeeg14gvpSIKAFGFQDEDLSLSLGAVYRYAKATQKSFT........PL 85 KFLVAHAGPTSNVRVEras46sclTVQTIMNMPHLTVQALALTFCHLKQFGFERI........LY 86 AKFFKDISCPLIHKQEydl12aikVMNEKIQLSPSLIRLVSKLYSHMVEYNNEQV........ML 87 KFLVAHAGPTSNVRVEras46sclTVHTIMNMPHLTVQALALTFCHLKQFGFERI........LY 88 GNSAVSINTAEINRLRnii36pvtHALVPELGLQLAMASCNALLRYLGPALLNPD........ME 89 GNSAVSINTAEINRLRnii36pvtHALVPELGLQLAMASCNALLRYLGPALLNPD........ME 90 LNPLQDVISNCNVLLTekk25svePVRDLLSQFDYALGPLGALLSYAELLADDTN........YG 91 SLYDSLERCAVMITERkkh23niePVRDLVSGFDLATPALGALLSFSELLSNEDN........YG 92 SLYDSLERCAVMITERkkh23niePVRDLVSGFDLATPALGALLSFSELLSNEDN........YG 93 MLIQRATNVR------........-------------------------------........-- 94 KIASMFTRMEVHNKQQlkp13iesVHLDYKDEAEKQNENIKECLQILHSNAADEY........SI 95 NSDRGGGAAGVCRRKRarr66rvpEDRLALSNCPLASRAIEYLVSNIIDNFDATN........HR 96 HPIYSFIQERKYFLSYven19keiDPSFIKYCTKLEVTAGCTLISYIADRLQNSHp.......NI 97 ----------------........-------------------------------........-- 98 SKLATMIKFNVAETVKiee29kkdLKIEEIIDKTFALCAASAAISYMEEIISKSSrn......-L 99 SKLATMIKFNVAETVKiee29kkdLKIEEIIDKTFALCAASAAISYMEEIISKSSrn......-L 100 STKLFTLITENFKNVNftt27efsTVLMEVQSKYYCLAAVAALLKYVEFIQNSVY........AP 101 STKLFTLITENFKNVNftt27efsTVLMEVQSKYYCLAAVAALLKYVEFIQNSVY........AP 102 ----------------........-------------------------------........-- 103 YIIIKMR---------........----FDIEAVNMIRSFGALLLFLDETRMGVTddplsvtsPI 104 YIIIKMR---------........----FDIEAVNMIRSFGALLLFLDETRMGVTddplsvtsPI 105 YIIIKMR---------........----FDIEAVNMIRSFGALLLFLDETRMGVTddplsvtsPI 106 ----------------........-------------------------------........-- 40 250 260 270 28 | | | | 1 QP........FRFYDP........GAFMRLPEATLRALEVFEPLRGQ........DTLFSVLDET 2 RS........ITMERQ........QDSIIMDAATRRNLEITQNLAGGve......NTLAAVLDCT 3 RS........ITMERQ........QDSIIMDAATRRNLEITQNLAGGve......NTLAAVLDCT 4 RS........ITMERE........QDSIIMDAATRRNLEITQNLAGGae......NTLASVLDCT 5 RS........ITMERE........QDSIIMDAATRRNLEITQNLAGGae......NTLASVLDCT 6 QS........ISLIQN........QDCIQLDAATRRNLELTQNLAGGte......NTLASVLDKC 7 RS........LTWDRQ........DQSVILDAATRRNLELTHNLAGGtd......NTLAEVLDHC 8 RS........ITMERE........QDSIIMDAATRRNLEITQNLAGGae......NTLASVLDCT 9 RG........LRHERL........DDTVILAGASRRNLELDVNLSGGrd......NTLQSVIDRC 10 RP........FRLYDP........GAIVRLPEASLKALEVFEPLRGQ........DTLFGVLDET 11 RS........LRHDRL........DDTVILDGASRRNLELDINLSGGre......NTLQSVVDRC 12 RS........LRHDRL........DDTVILDGASRRNLELDINLSGGre......NTLQSVVDRC 13 QP........FRFYDP........GAFMRLPEATLRALEVFEPLRGQ........DTLFSVLDET 14 ED........VVQYAA........IDYMKMDFYAKRNLELTESIRLKskk.....GTLLWLMDET 15 SM........ANFEEYipl20tkaYQRMVLDAVTLNNLEIFLNGTNGste.....GTLLERVDTC 16 SM........ANFEEYfpl20tkaSQRMVLDAVTLNNLEIFLNGTNGste.....GTLLERLDTC 17 SM........ANFEEYipl20tkaYQRMVLDAVTLNNLEIFLNGTNGste.....GTLLERVDTC 18 SM........ANFEEYipl20tkaYQRMVLDAVTLNNLEIFLNGTNGste.....GTLLERVDTC 19 SM........ANFEEYipl20tkaYQRMVLDAVTLNNLEIFLNGTNGste.....GTLLERVDTC 20 SM........ANFEEYipl20tkaYQRMVLDAVTLNNLEIFLNGTNGste.....GTLLERVDTC 21 KP........VIRYEI........KDFLQMDYATKASLDLVENARSGkkq.....GSLFWLLDET 22 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 23 RP........FRLYDP........GAFVRLPEASLKALEVFEPLRGQ........DTLFGVLDET 24 RP........FRLYDP........GAFVRLPEASLKALEVFEPLRGQ........DTLFGVLDET 25 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 26 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 27 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 28 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 29 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 30 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 31 SM........ANFEEYfpl20tkaSQRMVLDAVTLNNLEIFLNGTNGste.....GNLLERLDTC 32 QP........LKTYGL........TDFLVLDHQTRRNLEINQTVRDGsfh.....GSLLWALDRT 33 QP........LKTYGL........TDFLVLDHQTRRNLEINQTVRDGsfh.....GSLLWALDRT 34 KPesf.....KQLSSG........MEFMRINGTTLRNLEILQNQTDMktk.....GSLLWVLDHT 35 KPesf.....KQLSSG........MEFMRINGTTLRNLEMVQNQTDMktk.....GSLLWVLDHT 36 SMknike...YDFVKS........QHSMVLDGITLQNLEIFSNSFDGsdk.....GTLFKLFNRA 37 KPesf.....KQLSSG........MEFMRINGTTLRNLEMVQNQTDMktk.....GSLLWVLDHT 38 RP........FRLYDP........GAFVRLPEASLKALEVFEPLRGQ........DTLFGVLDET 39 KPesf.....KQLSSG........MEFMRINGTTLRNLEILQNQTDMktk.....GSLLWVLDHT 40 SMknike...YDFVKS........QHSMVLDGITLQNLEIFSNSFDGsdk.....GTLFKLFNRA 41 RF........AKFESLpyc10vneKQHMVLDAAALENLEIFENSRNGgys.....GTLYAQLNQC 42 QFe.......LATFDF........SQYMKLDMAAVRALNLFQGSVEDttgs....QSLAALLNKC 43 QFe.......LATFDF........SQYMKLDMAAVRALNLFQGSVEDttgs....QSLAALLNKC 44 QFe.......LATFDF........SQYMKLDMAAVRALNLFQGSVEDttgs....QSLAAFLNKC 45 DI........FPYQVY........RGCLRIDGQTMVNLEIFNNSCDGgps.....GTLYKYLDNC 46 KPenf.....KQLSSK........MEFMTINGTTLRNLEILQNQTDMktk.....GSLLWVLDHT 47 KPenf.....KQLSSK........MEFMTINGTTLRNLEILQNQTDMktk.....GSLLWVLDHT 48 TS........ITMETV........GEAITMNAATRRHLELDTRVDGEsr......HTLLGVLDST 49 DG........LSLETD........SQYIGMDAATRRNLEITQTLSGKks......PTLMSTLDLC 50 SMgnfde...YDASQQ........STSLLMNGQTLKNLEIFSNSFDGgse.....GTLFHLLCRC 51 DG........LSLETD........SQYIGMDAATRRNLEITQTLSGKks......PTLMSTLDLC 52 PI........PKIINF........HNYMTIDFSTRRNLEIVTNLQGNly......GSVLNTLNHT 53 SI........PKIYGQ........QKHLLIDKASQTNLELLSPIHGEhgk.....GSLLQVMERT 54 DI........FPYQVY........RGCLRIDGQTMVNLEIFNNSCDGvlq.....GPLNKYLENC 55 RF........AKFESLpyc10vneKQHMVLDAAALENLEIFENSRNGgys.....GTLYAQLNQC 56 QFv.......MTNFDL........SQYMKLDNAAVGALNLFPGSAEDtsgt....QSLAGLLNKC 57 KP........PLLISQ........RDYMILDSATVENLSLIPGDRGKn.......--LFDVLNNT 58 SI........PKIYGQ........HKHLLIDKASQTNLELLSAIHGEhgk.....GSLLQVMERT 59 AI........PQTRGK........QQKLLIDTASQVNLELLAPLNDPqgk.....NSLLRIMDHT 60 QP........VQVYEL........EEAMKIDLYSKRNLELTETIRSKnkk.....GSLLWLLDET 61 KP........PLLISQ........RDYMILDSATVENLSWIPGDRGKn.......--LFDVLNNT 62 SMrn......VTIYNSnsm15dwnGKNLILDGTALENLNIVPNGRDShl......TSLYYVINKC 63 DK........IDINND........SSYMFLDDVTQVNLELVKNNNDFssq.....YSLYSVLNDC 64 GI........PERESA........ASTLFIDPATRANLELAKTLSGSrd......GSLLKSLDRT 65 AI........PQTRGK........QQKLLIDTASQVNLELLAPLNDPqgk.....NSLLRIMDHT 66 QP........VQVYEL........EEAMKIDLYSKRNLELTETIRSKnkk.....GSLLWLLDET 67 QFe.......LTTFDF........SQYMKLDIAAVRALNLFQGSVEDttgs....QSLAALLNKC 68 ASnf......YQPFDS........ISSMVLSKQALEGLELFVNQTDHtpv.....GSLFWVLDRT 69 ASnf......YQPFDS........ISSMVLSKQALEGLELFVNQTDHtpv.....GSLFWVLDRT 70 EV........LPYHVY........KTCLRMDGQTLVNLEIFINNFNGgss.....GTLYKHLNHC 71 EV........LPYHVY........KTCLRMDGQTLVNLEIFINNFNGgss.....GTLYKHLNHC 72 SA........ITRYHI........HDFVEIDDATRKNLEILQNLHDStha.....HSLFETLNYT 73 QGas......FRSLSS........NTEMTLSANTLQQLEVVKNNSDGses.....GSLFHNMNHT 74 QI........PQRQLA........TAIMQIDSRTSTALELHSTVRDNnkk.....GSLLSSIRRT 75 QI........PQRQLA........TAIMQIDSRTSTALELHSTVRDNnkk.....GSLLSSIRRT 76 PMar......YQLY--vpp18tlrRSHMVLDATTLSNLRII---GEE........HSLLSTLDHC 77 IPr.......PKPYRD........EGFVRLDIKAIKGLEILESLEGRkd......ISLFKVIDRT 78 HYe.......IKQLDL........NRFVHLDSAAVAALNIMPKPGTHpsmpsyrwQSVLGVLDHC 79 QP........PIRVSL........NEYMIIGESAMKGLEIRSSLYQNryt.....GSLLHAINKT 80 QYq.......LYQHDL........AQFMKLDAAALKALNLMPGARDGakn.....MSLYGLLNHC 81 HYe.......IKQLDL........NRFVHLDSAAVAALNIMPKPGTHpsmpsyrwQSVLGVLDHC 82 HYe.......IKQLDL........NRFVHLDSAAVAALNIMPKPGTHpsmpsyrwQSVLGVLDHC 83 IPsi......YSPFAS........KIHMLLDPNSLQSLDIFTHDGGK........GSLFWLLDHT 84 IPk.......PKPYVD........EGYVKLDLKAVKGLEITESIEGRkd......LSLFKVVDRT 85 QGas......FRSLSS........NTEMTLSANTLQQLEVVKNNSDGses.....GSLFHNMNHT 86 IPsi......YSPFAS........KIHMLLDPNSLQSLDIFTHDGGK........GSLFWLLDHT 87 QGas......FRSLSS........NTEMTLSANTLQQLEVVKNNSDGses.....GSLFHNMNHT 88 DDren9rklhLYHHNL........EQYMRLDIAAVRSLNLLPPPNGNahkt....MSLYGLLNHC 89 DDren9rklhLYHHNL........EQYMRLDIAAVRSLNLLPPPNGNahkt....MSLYGLLNHC 90 NYt.......IEKYNL........NCYMRLDSAAVRALNIAEGKTDVnkn.....FSLFGLMNRT 91 NFt.......IRRYDI........GGFMRLDSAAMRALNVMESKTDAnkn.....FSLFGLMNRT 92 NFt.......IRRYDI........GGFMRLDSAAMRALNVMESKTDAnkn.....FSLFGLMNRT 93 --........------........-----------------------........---------- 94 SEkys.....IFNYGT........HGNMLIDSCAVEALELFQLNYNYleksnn..LTLYNVLNKC 95 AFy.......LKHTIP........STFMKLDTAAIQALHIIHQKPEArgslp...TSVYSWLNRC 96 QP........PIRVSL........NEYMIIGESAMKGLEIRSSLYQNryt.....GSLLHAINKT 97 --........------........-----------------------........---------- 98 NAfrklr...IQFEGT........ENTMLIDSKTVRGLELVENKLDKng......ISLWKFLDTT 99 NAfrklr...IQFEGT........ENTMLIDSKTVRGLELVENKLDKng......ISLWKFLDTT 100 KSlk......ICFQGS........EQTAMIDSSSAQNLELLINNQDYrnn.....HTLFGVLNYT 101 KSlk......ICFQGS........EQTAMIDSSSAQNLELLINNQDYrnn.....HTLFGVLNYT 102 --........------........-----------------------........---------- 103 KS........IKTFTL........GNLVEIDFNTIQALDILPKETENkktfgqg.RSLYQLMDKC 104 KS........IKTFTL........GNLVEIDFNTIQALDILPKETENkktfgqg.RSLYQLMDKC 105 KS........IKTFTL........GNLVEIDFNTIQALDILPKETENkktfgqg.RSLYQLMDKC 106 --........------........-----------------------........---------- 0 290 300 | | | 1 RT.APGRRLLQSWLRHPLLDRG 2 VT.PMGSRMLKRWLHMPVRN-- 3 VT.PMGSRMLKRWLHMPVRN-- 4 VT.PMGSRMLKRWLHMPVRD-- 5 VT.PMGSRMLKRWLHMPVRD-- 6 VT.PMGSRLLKRWIHQPVRD-- 7 AT.PMGSRMLKRWIHQPMRD-- 8 VT.PMGSRMLKRWLHMPV---- 9 QT.AMGSRLLGRWLNRPLRDR- 10 RT.APGRRLLQAWLRHPLLERG 11 QT.AMASRLMSRWLNRPLRDR- 12 QT.AMASRLMSRWLNRPLRDR- 13 RT.APGRRLLQSWLRHPLLDRG 14 KT.PMGARRLKQWIDRPLISKE 15 HT.PFGKRLLKQWLCAPLCN-- 16 HT.PFGKRLLKQWLCAPLCS-- 17 HT.PFGKRLLKQWLCAPLCN-- 18 HT.PFGKRLLKQWLCAPLCN-- 19 HT.PFGKRLLKQWLCAPLCN-- 20 HT.PFGKRLLKQWLCAPLCN-- 21 KT.AMGMRLLRSWIHRPLIDKE 22 KT.PQGQRLVNQWIKQPLMDKN 23 RT.APGRRLLQAWLRHPLLERG 24 RT.APGRRLLQAWLRHPLLERG 25 KT.PQGQRLVNQWIKQPLMDKN 26 KT.PQGQRLVNQWIKQPLMDKN 27 KT.PQGQRLVNQWIKQPLMDKN 28 KT.PQGQRLVNQWIKQPLMDKN 29 KT.PQGQRLVNQWIKQPLMDKN 30 KT.PQGQRLVNQWIKQPLMDKN 31 HT.PFGKRLLKQWLCAPLCS-- 32 ST.TMGSRALRRWLLQPLLD-- 33 ST.TMGSRALRRWLLQPLLD-- 34 KT.SFGRRKLKNWVTQPLL--- 35 KT.SFGRRKLKNWVTQPLL--- 36 IT.PMGKRMMKKWLMHPLLRKN 37 KT.SFGRRKLKNWVTQPLL--- 38 RT.APGRRLLQAWLRHPLLERG 39 KT.SFGRRKLKNWVTQPLL--- 40 IT.PMGKRMMKKWLMHPLLRKN 41 IT.ASGKRLLKTWLARPLYN-- 42 KT.AQGQRLVNQWIKQPLMDRN 43 KT.AQGQRLVNQWIKQPLMDRN 44 KT.AQGQRLVSQWIKQPLMDKN 45 VS.PTGKRLLRNWICHPLKD-- 46 KT.SFGRRKLKKWVTQPLL--- 47 KT.SFGRRKLKKWVTQPLL--- 48 VT.PMGGRLLRRWLHRPLR--- 49 AT.HMGSRLLALWLHHPLRNR- 50 VT.PFGKRLFHTWLCHPLR--- 51 AT.HMGSRLLALWLHHPLRNR- 52 VT.TQGGRLLYHFLSSPLTN-- 53 ST.PMGGRLLRNTLINPFYD-- 54 VS.PTGKRLLRNWICHPLKD-- 55 IT.ASGKRLLKTWLARPLYN-- 56 KT.PQGQRLVNQWIKQPLMDKN 57 ET.PMGARLLKKWILHPLVDRK 58 ST.PMGGRLLRNTLVNPFYD-- 59 ST.PMGGRLLRQILISPFYN-- 60 KT.AMGGRLLKQWIDRPLI--- 61 ET.PMGARLGKKWILHPLVDRK 62 ST.PFGRRLLRSWLLQPTCD-- 63 KT.AMGKRLLREFILNPILN-- 64 MT.SGGARLLAERLMSPLTD-- 65 ST.PMGGRLLRQILISPFYN-- 66 KT.AMGGRLLKQWIDRPLI--- 67 KT.PQG---------------- 68 YT.RFGQRMLQRWLQKPLVDKE 69 YT.RFGQRMLQRWLQKPLVDKE 70 VT.ASGKRMLRRWICHPLKD-- 71 VT.ASGKRMLRRWICHPLKD-- 72 HT.AMGTRLLRYWLHHPLRS-- 73 LT.VYGSRLLRHWVTHPLCDRN 74 VT.PSGTRLLSQWLSGPSLD-- 75 VT.PSGTRLLSQWLSGPSLD-- 76 CT.KFGKRLLHHWLCAPSCD-- 77 LT.GMGRRRLKFRLLSPFRSRE 78 RT.PQGHRLMGQWVKQPLRSRN 79 VT.KSGSRLLTRRLCAPST--- 80 KT.PVGSRLLSQWLKQPLMN-- 81 RT.PQGHRLMGQWVKQPLRSRN 82 RT.PQGHRLMGQWVKQPLRSRN 83 RT.SFGLRMLREWILKPLVD-- 84 LT.GMGRRRLRFRLLNPFR--- 85 LT.VYGSRLLRHWVTHPLCDRN 86 RT.SFGLRMLREWILKPLVD-- 87 LT.VYGSRLLRHWVTHPLCDRN 88 RT.AMGARNLRRWIVQPLLD-- 89 RT.AMGARNLRRWIVQPLLD-- 90 CTvGMGKRLLNRWLKQPLLD-- 91 CTaGMGKRLLHMWLKQPLVD-- 92 CTaGMGKRLLHMWLKQPLVD-- 93 --.------------------- 94 KT.LPGEKLLRDWLSRPLC--- 95 VT.GMGSRMMRQWLLQPLRN-- 96 VT.KSGSRLLTRRLCAPST--- 97 --.------------------- 98 ST.KMGQRSLRNSILQPLTDRG 99 ST.KMGQRSLRNSILQPLTDRG 100 KT.PGGSRRLRSNILEPLVD-- 101 KT.PGGSRRLRSNILEPLVD-- 102 --.------------------- 103 RS.TVGKKCLRKWFRNPTTDRD 104 RS.TVGKKCLRKWFRNPTTDRD 105 RS.TVGKKCLRKWFRNPTTDRD 106 --.-------------------