; SAM: prettyalign v3.2 (June, 2000) compiled 07/10/00_09:40:44 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequence numbers correspond to the following labels: ; 1 gi|3886083|gb|AAC78226.1|_17:834 ; 2 gi|3914075|sp|O51737|MUTS_BORBU_4:825 ; 3 gi|172000|gb|AAA34801.1|_69:957 ; 4 gi|6321912|ref|NP_011988.1|_69:957 ; 5 gi|7522430|pir||T38256_2:767 ; 6 gi|6473463|dbj|BAA87137.1|_2:169 ; 7 gi|6166561|sp|O13921|MSH1_SCHPO_49:928 ; 8 gi|7482290|pir||C69102_169:642 ; 9 gi|7514768|pir||A75007_73:551 ; 10 gi|7518647|pir||C71155_57:549 ; 11 gi|6227005|gb|AAF06041.1|AC009360_6_110:630 ; 12 gi|7473468|pir||A75332_6:536 ; 13 gi|8809580|dbj|BAA97131.1|_143:663 ; 14 gi|3914083|sp|P73625|MUS2_SYNY3_53:577 ; 15 gi|3914084|sp|P94545|MUS2_BACSU_18:558 ; 16 gi|7387927|sp|Q9ZEH5|MUS2_STAAU_20:490 ; 17 gi|7387923|sp|Q9X105|MUS2_THEMA_21:541 ; 18 gi|3914080|sp|O67287|MUS2_AQUAE_35:554 ; 19 gi|3914072|sp|O51125|MUS2_BORBU_40:531 ; 20 gi|3914057|sp|O25338|MUS2_HELPY_45:550 ; 21 gi|7387931|sp|Q9ZLL4|MUS2_HELPJ_45:551 ; 22 gi|6968488|emb|CAB73308.1|_30:527 ; 23 gi|8572747|gb|AAF77187.1|AF264911_3_30:527 ; 24 gi|730066|sp|P40965|MSH4_YEAST_97:813 ; 25 gi|6321109|ref|NP_011187.1|_97:815 ; 26 gi|7493777|pir||T18246_42:771 ; 27 gi|4336728|gb|AAD17920.1|_148:883 ; 28 gi|4505251|ref|NP_002431.1|_148:883 ; 29 gi|5815430|gb|AAD52669.1|AF178755_1_43:788 ; 30 gi|6319935|ref|NP_010016.1|_152:1039 ; 31 gi|448278|prf||1916402A_152:1038 ; 32 gi|3914062|sp|O65607|MSH3_ARATH_94:1039 ; 33 gi|7269404|emb|CAB81364.1|_94:1039 ; 34 gi|3319876|emb|CAA07684.1|_94:1044 ; 35 gi|1083296|pir||JC4019_189:1086 ; 36 gi|6981224|ref|NP_034959.1|_143:374 ; 37 gi|110917|pir||A32495_175:918 ; 38 gi|400971|sp|P13705|MSH3_MOUSE_175:1051 ; 39 gi|387849|gb|AAB60711.1|_175:1051 ; 40 gi|4505249|ref|NP_002430.1|_211:1091 ; 41 gi|118951|sp|P20585|MSH3_HUMAN_220:1100 ; 42 gi|1076927|pir||S22569_4:856 ; 43 gi|135075|sp|P26359|SWI4_SCHPO_94:958 ; 44 gi|7331984|gb|AAF60672.1|_840:1781 ; 45 gi|7294307|gb|AAF49656.1|_249:980 ; 46 gi|7512474|pir||JC5839_394:1354 ; 47 gi|7512473|pir||JC5840_394:1057 ; 48 gi|1709123|sp|P52701|MSH6_HUMAN_394:1354 ; 49 gi|1082386|pir||A56742_326:1286 ; 50 gi|4504191|ref|NP_000170.1|_394:1354 ; 51 gi|6754744|ref|NP_034960.1|_393:1350 ; 52 gi|2506881|sp|P54276|MSH6_MOUSE_393:1350 ; 53 gi|4775578|emb|CAB42555.1|_353:1132 ; 54 gi|4775580|emb|CAB42556.1|_46:825 ; 55 gi|2522394|gb|AAB82654.1|_1:86 ; 56 gi|6224917|gb|AAF06013.1|AF193018_1_255:1054 ; 57 gi|7547005|gb|AAF63754.1|AF242852_1_65:255 ; 58 gi|4165574|emb|CAA10614.1|_1:90 ; 59 gi|7012942|gb|AAF35250.1|AF227632_1_1:589 ; 60 gi|6226648|sp|O04716|MSH6_ARATH_367:1283 ; 61 gi|2104549|gb|AAB57798.1|_384:1321 ; 62 gi|7492209|pir||T41262_362:1228 ; 63 gi|6320302|ref|NP_010382.1|_299:1168 ; 64 gi|1588283|prf||2208298A_299:1168 ; 65 gi|6093453|sp|O83348|MUTS_TREPA_4:812 ; 66 T0116 ; 67 gi|2497995|sp|Q56215|MUTS_THEAQ_3:810 ; 68 gi|2145507|pir||S62790_18:817 ; 69 gi|2497996|sp|Q56239|MUTS_THETH_11:818 ; 70 gi|1871501|dbj|BAA09880.1|_11:818 ; 71 gi|7387928|sp|Q9ZIX6|MUTS_THECA_9:816 ; 72 gi|7448108|pir||S74860_52:875 ; 73 gi|7404405|sp|P73769|MUTS_SYNY3_18:841 ; 74 gi|7387924|sp|Q9Z6W5|MUTS_CHLPN_4:810 ; 75 gi|7189834|gb|AAF38705.1|_4:810 ; 76 gi|7387913|sp|O84797|MUTS_CHLTR_4:804 ; 77 gi|4587688|gb|AAD25857.1|_1:99 ; 78 gi|4587708|gb|AAD25867.1|_1:99 ; 79 gi|7190210|gb|AAF39048.1|_3:804 ; 80 gi|7379009|emb|CAB83555.1|_4:860 ; 81 gi|7227419|gb|AAF42468.1|_4:860 ; 82 gi|1171081|sp|P44834|MUTS_HAEIN_3:858 ; 83 gi|1592569|gb|AAB97931.1|_6:850 ; 84 gi|4887554|emb|CAB43497.1|_6:850 ; 85 gi|127556|sp|P23909|MUTS_ECOLI_6:850 ; 86 gi|417330|sp|P10339|MUTS_SALTY_6:851 ; 87 gi|79102|pir||A28668_6:850 ; 88 gi|127555|sp|P27345|MUTS_AZOVI_3:851 ; 89 gi|7229490|gb|AAF42850.1|_3:851 ; 90 gi|7108493|gb|AAF36440.1|AF126491_1_3:850 ; 91 gi|7243293|dbj|BAA92687.1|_42:560 ; 92 gi|5305132|emb|CAB46193.1|_1:218 ; 93 gi|7448107|pir||T08098_1:116 ; 94 gi|4587710|gb|AAD25868.1|_1:99 ; 95 gi|4587698|gb|AAD25862.1|_1:99 ; 96 gi|4587700|gb|AAD25863.1|_1:99 ; 97 gi|4587702|gb|AAD25864.1|_1:99 ; 98 gi|4587694|gb|AAD25860.1|_1:99 ; 99 gi|7328295|emb|CAB82462.1|_3:360 ; 100 gi|7188744|gb|AAF37851.1|AF227730_1_3:345 ; 101 gi|8473172|sp|P56883|MUTS_RHIME_20:910 ; 102 gi|9106782|gb|AAF84525.1|AE003995_7_39:900 ; 103 gi|4100661|gb|AAD00921.1|_6:129 ; 104 gi|8052216|emb|CAB92351.1|_6:128 ; 105 gi|7328284|emb|CAB82466.1|_2:419 ; 106 gi|7404403|sp|P49849|MUTS_BACSU_3:818 ; 107 gi|1002520|gb|AAB19235.1|_2:812 ; 108 gi|123080|sp|P10564|HEXA_STRPN_4:794 ; 109 gi|3024198|sp|P70755|MUTS_AQUPY_5:826 ; 110 gi|3914079|sp|O66652|MUTS_AQUAE_4:828 ; 111 gi|6226653|sp|P74926|MUTS_THEMA_3:768 ; 112 gi|1619909|gb|AAB16999.1|_3:768 ; 113 gi|6647605|sp|Q9ZDM9|MUTS_RICPR_12:888 ; 114 gi|6324482|ref|NP_014551.1|_9:918 ; 115 gi|172002|gb|AAA34802.1|_9:918 ; 116 gi|1079288|pir||S53609_16:898 ; 117 gi|1709122|sp|P54275|MSH2_RAT_18:897 ; 118 gi|6678938|ref|NP_032654.1|_18:899 ; 119 gi|726086|gb|AAA75027.1|_18:899 ; 120 gi|1000879|gb|AAB59570.1|_18:482 ; 121 gi|2135744|pir||I37550_18:856 ; 122 gi|1000883|gb|AAB59571.1|_18:528 ; 123 gi|7448104|pir||I64827_18:787 ; 124 gi|4557761|ref|NP_000242.1|_18:899 ; 125 gi|1000875|gb|AAB59568.1|_18:377 ; 126 gi|1000877|gb|AAB59569.1|_18:423 ; 127 gi|3914053|sp|O13396|MSH2_NEUCR_7:870 ; 128 gi|7490470|pir||T39976_7:377 ; 129 gi|4151103|emb|CAA07342.1|_20:925 ; 130 gi|7522263|pir||T39832_20:579 ; 131 gi|4775576|emb|CAB42554.1|_29:905 ; 132 gi|4099512|gb|AAD00647.1|_1:117 ; 133 gi|4139230|gb|AAD04176.1|_26:899 ; 134 gi|3914056|sp|O24617|MSH2_ARATH_26:899 ; 135 gi|7298155|gb|AAF53392.1|_17:801 ; 136 gi|7287834|gb|AAF44872.1|AE003406_77_17:888 ; 137 gi|1174416|sp|P43248|MSH2_DROME_8:860 ; 138 gi|8515837|gb|AAF76200.1|_89:829 ; 139 gi|3831701|gb|AAC70065.1|_89:829 ; 140 gi|3914066|sp|Q19272|MSH5_CAEEL_89:930 ; 141 gi|5814102|gb|AAD52100.1|_4:247 ; 142 gi|3986757|gb|AAC84154.1|_15:779 ; 143 gi|7305281|ref|NP_038628.1|_15:779 ; 144 gi|5725250|emb|CAB52406.1|_46:797 ; 145 gi|4505253|ref|NP_002432.1|_46:780 ; 146 gi|7512546|pir||T34526_2:248 ; 147 gi|3108220|gb|AAC62533.1|_46:780 ; 148 gi|6320047|ref|NP_010127.1|_97:878 ; 149 gi|1582703|prf||2119252A_97:878 ; 150 gi|3914061|sp|O63852|MSHM_SARGL_17:857 ; 151 gi|2147739|pir||S58881_17:857 10 20 30 40 50 | | | | | 1 ----------------------LKSKSPNTIAIFSRGEYFSVYG.D........DATFVATNIFK 2 -----------NVTPMIRQYLDIKKKYKDAVLFFRVGSFYEMFF.D........DAIEVSKLLNL 3 --LSSTEPSKASLPPSLQYVRDLMDLYKDHVVLTQMGSFYELYF.E........QAIRYAPELNI 4 --LSSTEPSKASLPPSLQYVRDLMDLYKDHVVLTQMGSFYELYF.E........QAIRYAPELNI 5 --------------------------------------------.-........----------- 6 --------------------------------------------.-........----------- 7 -LDFIRPKEKVTLPPLLKEVSFQQKKFADCVLLTKVGNFYEMYF.E........QAEKIGPLLNL 8 --------------------------------------------.-........----------- 9 --------------------------------------------.-........----------- 10 --------------------------------------------.-........----------- 11 --------------------------------------------.-........----------- 12 --------------------------------------------.-........----------- 13 --------------------------------------------.-........----------- 14 --------------------------------------------.-........----------- 15 --------------------------------------------.-........----------- 16 --------------------------------------------.-........----------- 17 --------------------------------------------.-........----------- 18 --------------------------------------------.-........----------- 19 --------------------------------------------.-........----------- 20 --------------------------------------------.-........----------- 21 --------------------------------------------.-........----------- 22 --------------------------------------------.-........----------- 23 --------------------------------------------.-........----------- 24 --------------------------------------------.-........----------- 25 --------------------------------------------.-........----------- 26 --------------------------------------------.-........----------- 27 --------------------------------------------.-........----------- 28 --------------------------------------------.-........----------- 29 --------------------------------------------.-........----------- 30 ---KARKSPTAKLTPLDKQVKDLKMHHRDKVLVIRVGYKYKCFA.E........DAVTVSRILHI 31 ---KARKSPTAKLTPLDKQVKDLKMHHRDKVLVIRVGYKY-CFA.E........DAVTVSRILHI 32 --YVPETSSSRKYTPLEQQVVELKSKYPDVVLMVEVGYRYRFFG.E........DAEIAARVLGI 33 --YVPETSSSRKYTPLEQQVVELKSKYPDVVLMVEVGYRYRFFG.E........DAEIAARVLGI 34 --YVPETSSSRKYTPLEQQVVELKSKYPDVVLMVEVGYRYRFFG.E........DAEIAARVLGI 35 DCKPFNKRSKSVYTPLELQYLDMKQQHKDAVLCVECGYKYRFFG.E........DAEIAARELNI 36 DCKPFNKRSKSVYTPLELQYLDMKQQHKDAVLCVECGYKYRFFG.E........DAEIAARELNI 37 DCKPFNKRSKSVYTPLELQYLDMKQQHKDAVLCVECGYKYRFFG.E........DAEIAARELNI 38 DCKPFNKRSKSVYTPLELQYLDMKQQHKDAVLCVECGYKYRFFG.E........DAEIAARELNI 39 DCKPFNKRSKSVYTPLELQYLDMKQQHKDAVLCVECGYKYRFFG.E........DAEIAARELNI 40 ---SANKRSKSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFG.E........DAEIAARELNI 41 ---SANKRSKSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFG.E........DAEIAARELNI 42 -----PTKQKSVFTPLEQQYLELKKNYQETILAIEVGYKFRFFG.K........DAKIASEVLGI 43 ---SKPTKQKSVFTPLEQQYLELKKNYQETILAIEVGYKFRFFG.K........DAKIASEVLGI 44 KTLWVPPDFHQKQTPGHRQWWTMKSQHFDTILLFKVGKFYETYH.M........DAVEVVRALNI 45 STLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYH.M........DADVGVNELGF 46 STLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYH.M........DALIGVSELGL 47 STLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYH.M........DALIGVSELGL 48 STLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYH.M........DALIGVSELGL 49 STLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYH.M........DALIGVSELGL 50 STLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYH.M........DALIGVSELGL 51 TTLYVPEEFLNSCTPGMRKWWQLKSQNFDLVIFYKVGKFYELYH.M........DAVIGVSELGL 52 TTLYVPEEFLNSCTPGMRKWWQLKSQNFDLVIFYKVGKFYELYH.M........DAVIGVSELGL 53 STLFIPPDALRKMSTSQKQYWNIKCKYMDVVLFFKVGKFYELYE.L........DAEIGQKELDW 54 STLFIPPDALRKMSTSQKQYWNIKCKYMDVVLFFKVGKFYELYE.L........DAEIGQKELDW 55 --------------------------------------------.-........----------- 56 KTLHIPPDVFKKMSASQKQYWSVKSEYMDIVLFFKVGKFYELYE.L........DAELGHKELDW 57 -----------KYTPLEQQVVELKRKHPDVILMVEVGYRYRFFG.E........DAEIAARVLGI 58 --------------------------------------------.-........----------- 59 --------------------------------------------.-........----------- 60 RTLYLPPDFVKKLTGGQRQWWEFKAKHMDKVVFFKMGKFYELFE.M........DAHVGAKELDI 61 ----LTGGQVRRAHGNLRQWWEFKAKHMDKVVFFKMGKFYELFE.M........DAHVGAKELDI 62 RTLYIPPSAWATFKPFEKQFWKIKKDLMDTVVFFQKGKFYELYE.N........DAAIGHQVFSL 63 RTLYIPSSAWNKFTPFEKQYWEIKSKMWDCIVFFKKGKFFELYE.K........DALLANALFDL 64 RTLYIPSSAWNKFTPFEKQYWEIKSKMWDCIVFFKKGKEFELYE.K........DALLANALFDL 65 ---------LASDTPLMRQYHAIRAQHPDAVLFFRLGDFYEMFD.S........DALHVSTLLGL 66 MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFG.E........DAERLARALGL 67 --GMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFG.E........DAERLARALGL 68 ----------PPLPPLLQQYVELRDRYPDYLLLFQVGDFYECFG.E........DAERLARALGL 69 --GMLKGEGPGPLPPLLQQYVELRDRYPDYLLLFQVGDFYECFG.E........DAERLARALGL 70 --GMLKGEGPGPLPPLLQQYVELRDRYPDYLLLFQVGDFYECFG.E........DAERLARALGL 71 ---MLKGEGPGPLPPLLQQYVELRDRYPDYLLLFQVGDFYECFG.E........DAERLARALGL 72 -----RTLDRQKLTPMFQHYTEVKEQYQGALLLYRVGDFFECFF.Q........DAVIIARELEL 73 -----RTLDRQKLTPMFQHYTEVKEQYQGALLLYRVGDFFECFF.Q........DAVIIARELEL 74 ----------KKPTPMMEQWHQCKEKAGDSVLLFRMGDFYEAFY.D........DAVLLSQHLEL 75 ----------KKPTPMMEQWHQCKEKAGDSVLLFRMGDFYEAFY.D........DAVLLSQHLEL 76 -----------KLTPMMQQWHQCKEQAGDCLLLFRLGEFYEAFF.D........DALILAQNLDI 77 --------------------------------------------.-........----------- 78 --------------------------------------------.-........----------- 79 ----------QKLTPMMQQWHQCKEQAGDCLLLFRLGEFYEAFF.D........DALVLAQNLDI 80 ----------SAVSPMMQQYLGIKAQHTDKLVFYRMGDFYEMFF.D........DAVEAAKLLDI 81 ----------SAVSPMMQQYLGIKAQHTDKLVFYRMGDFYEMFF.D........DAVEAAKLLDI 82 -----SEENFQQHTPMMQQYLKLKAENPDILLFYRMGDFYELFY.D........DAKKAAALLDI 83 --------NFDAHTPMMQQYLKLKAQHPEILLFYRMGDFYELFY.D........DAKRASQLLDI 84 --------NFDAHTPMMQQYLKLKAQHPEILLFYRMGDFYELFY.D........DAKRASQLLDI 85 --------NFDAHTPMMQQYLRLKAQHPEILLFYRMGDFYELFY.D........DAKRASQLLDI 86 ------DKDFSNHTPMMQQYLKLKAQHPEILLFYRMGDFYELFY.D........DAKRASQLLDI 87 ------DKDFSNHTPMMQQYLKLKAQHPEILLFYRMGDFYELFY.D........DAKRASQLLDI 88 --------SLSQHTPMMQQYWKLKREHPDQLMFYRMGDFYELFY.E........DAKKAAKLLDI 89 --------DLSQHTPMMQQYFKLKHQHPDQLMFYRMGDFYELFY.E........DAKKAAKLLDI 90 --------DLSQHTPMMQQYFKLKHQHPDQLMFYRMGDFYELFY.E........DAKKAAKLLDI 91 --------------------------------------------.-........----------- 92 --------------------------------------------.-........----------- 93 --------------------------------------------.-........----------- 94 --------------------------------------------.-........----------- 95 --------------------------------------------.-........----------- 96 --------------------------------------------.-........----------- 97 --------------------------------------------.-........----------- 98 --------------------------------------------.-........----------- 99 --------------------------------------------.-........----------- 100 --------------------------------------------.-........----------- 101 ---LASEESRSTATPMMEQFIEIKANNPDSLLFYRMGDFYELFF.Q........DAVEASRALGI 102 --KPEGGKGMAEHTPLMKQYFAAKAEYPDLLLFFRMGDFYELFH.Q........DARKAARLLDI 103 --------------------------------------------.-........----------- 104 --------------------------------------------.-........----------- 105 ----------SNVTPMMQQYLKIKSEYQDCLLFFRLGDFYEMFY.E........DAKEASRVLEI 106 -----------GYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFF.E........DAKKASQELEI 107 ----------------IQQYLKIKAEHQDAFLFFRLGDFYEMFF.E........DAKKASQELEI 108 ----------EKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFY.E........DAVNAAQILEI 109 ---------EKELTPMLAQYHQFKSMYPDCLLLFRLGDFYELFY.E........DAVVGSKELGL 110 --------SEKELTPMLSQYHYFKNQYPDCLLLFRLGDFYELFY.E........DAYIGSKELGL 111 ------------VTPLMEQYLRIKEQYKDSILLFRLGDFYEAFF.E........DAKIVSKVLNI 112 ------------VTPLMEQYLRIKEQYKDSILLFRLGDFYEAFF.E........DAKIVSKVLNI 113 ----RQKYNYNVATKMMQQYLDIKFAHLDCLLLFRMGDFYELFY.E........DAILASNILGI 114 -----KFSDVSEERNFYKKYTGLPKKPLKTIRLVDKGDYYTVIG.S........DAIFVADSVYH 115 -----KFSDVSEERNFYKKYTGLPKKPLKTIRLVDKGDYYTVIG.S........DAIFVADSVYH 116 ------------ENGFLHFYQSMPEKPDTTVRVFDRNDYYTVHG.G........DALFAAKEVFK 117 --------------GFVRFFEGMPEKPSTTVGLFDRGDFYTAHG.E........DALLAAREVFK 118 --------------GFVRFFEGMPEKPSTTVRLFDRGDFYTAHG.E........DALLAAREVFK 119 --------------GFVRFFEGMPEKPSTTVRLFDRGDFYTAHG.E........DALLAAREVFK 120 --------------GFVRFFQGMPEKPTTTVRLFDRGDFYTAHG.E........DALLAAREVFK 121 --------------GFVRFFQGMPEKPTTTVRLFDRGDFYTAHG.E........DALLAAREVFK 122 --------------GFVRFFQGMPEKPTTTVRLFDRGDFYTAHG.E........DALLAAREVFK 123 --------------GFVRFFQGMPEKPTTTVRLFDRGDFYTAHG.E........DALLAAREVFK 124 --------------GFVRFFQGMPEKPTTTVRLFDRGDFYTAHG.E........DALLAAREVFK 125 --------------GFVRFFQGMPEKPTTTVRLFDRGDFYTAHG.E........DALLAAREVFK 126 --------------GFVRFFQGMPEKPTTTVRLFDRGDFYTAHG.E........DALLAAREVFK 127 -------LKVDDEHGFIRFYKSLPQLGEEAIRIFDRGDWYTAHG.D........DATFIARTVYK 128 --------------------------------------------.-........----------- 129 ------------------NFYEKMPKDTNTVRVFDRGEFYVAIG.E........DASFVAQNAYH 130 ------------------NFYEKMPKDTNTVRVFDRGEFYVAIG.E........DASFVAQNAYH 131 -------------------FFKKLPQDPRAVRLFDRRDYYTAHG.E........NATFIARTYYH 132 --------------------------------------------.-........----------- 133 ------------------SFYKTLPNDTRAVRFFDRKDYYTAHG.E........NSVFIAKTYYH 134 ------------------SFYKTLPNDTRAVRFFDRKDYYTAHG.E........NSVFIAKTYYH 135 --------DTNARRNFIKFHAKLGEKPATTVRFFDHTDRYTVHGsD........DCELVAKIVYK 136 --------DTNARRNFIKFHAKLGEKPATTVRFFDHTDRYTVHGsD........DCELVAKIVYK 137 ---TYPEYGHKCASNFIKFHAKLGEKPATTVRFFDHTDRYTVHGsD........DCELVAKIVYK 138 --------------------------------------------.-........----------- 139 --------------------------------------------.-........----------- 140 --------------------------------------------.-........----------- 141 --------------------------------------------.-........----------- 142 --------------------------------------------.-........----------- 143 --------------------------------------------.-........----------- 144 --------------------------------------------.-........----------- 145 --------------------------------------------.-........----------- 146 --------------------------------------------.-........----------- 147 --------------------------------------------.-........----------- 148 --------------------------------------------.-........----------- 149 --------------------------------------------.-........----------- 150 -----------------------SKYGLSVIQLIQIGKFYELWH.Epdt17llvESSIRSRSLEV 151 -----------------------SKYGLSVIQLIQIGKFYELWH.Epdt17llvESSIRSRSLEV 60 70 80 90 100 | | | | | 1 SDVCVKtftlst..DNS....QQMKYISVNRGQYEKVVRETIv.LLRCSVELYSSEQG-...--- 2 TLT---........-KR....ENVPMCGVPYHTSKEYIRKLI..LFDKKVAICEQASN-...STS 3 SLTNRA........YSH....GKVPFAGFPVHQLSRHLKMLVn.NCGYSVTIAEQFKKK...DVA 4 SLTNRA........YSH....GKVPFAGFPVHQLSRHLKMLVn.NCGYSVTIAEQFKKK...DVA 5 ------........---....---------------------..---------------...--- 6 ------........---....---------------------..---------------...--- 7 RVSKKK........TSK....SDVSMAGFPFFKLDRYLKILVe.DLKKCVALSEEVIRPvddLSS 8 ------........---....---------------------..---------------...--- 9 ------........---....---------------------..---------------...--- 10 ------........---....---------------------..---------------...--- 11 ------........---....---------------------..---------------...--- 12 ------........---....---------------------..---------------...--- 13 ------........---....---------------------..---------------...--- 14 ------........---....---------------------..---------------...--- 15 ------........---....---------------------..---------------...--- 16 ------........---....---------------------..---------------...--- 17 ------........---....---------------------..---------------...--- 18 ------........---....---------------------..---------------...--- 19 ------........---....---------------------..---------------...--- 20 ------........---....---------------------..---------------...--- 21 ------........---....---------------------..---------------...--- 22 ------........---....---------------------..---------------...--- 23 ------........---....---------------------..---------------...--- 24 ------........---....---------------------..---------------...--- 25 ------........---....---------------------..---------------...--- 26 ------........---....---------------------..---------------...--- 27 ------........---....---------------------..---------------...--- 28 ------........---....---------------------..---------------...--- 29 ------........---....---------------------..---------------...--- 30 KLVPGKlti10pqdCNH....RQFAYCSFPDVRLNVHLERLV..HHNLKVAVVEQAETS...AIK 31 KLVPGKlti10pqdCNH....RQFAYCSFPDVRLNVHLERLV..HHNLKVAVVEQAETS...AIK 32 YA----........HMD....HNFMTA---------------..--RYKIGVVKQTETA...AIK 33 YA----........HMD....HNFMTA---------------..--GYKIGVVKQTETA...AIK 34 YA----........HMD....HNFMTASVPTFRLNFHVRRLV..NAGYKIGVVKQTETA...AIK 35 YC----........HLD....HNFMTASIPTHRLFVHVRRLV..AKGYKVGVVKQTETA...ALK 36 YC----........HLD....HNFMTASIPTHRLFVHVRRLV..AKGYKVGVVKQTETA...ALK 37 YC----........HLD....HNFMTASIPTHRLFVHVRRLV..AKGYKVGVVKQTETA...ALK 38 YC----........HLD....HNFMTASIPTHRLFVHVRRLV..AKGYKVGVVKQTETA...ALK 39 YC----........HLD....HNFMTASIPTHRLFVHVRRLV..AKGYKVGVVKQTETA...ALK 40 YC----........HLD....HNFMTASIPTHRLFVHVRRLV..AKGYKVGVVKQTETA...ALK 41 YC----........HLD....HNFMTASIPTHRLFVHVRRLV..AKGYKVGVVKQTETA...ALK 42 SC----........YFE....HNFLNASVPSYRIDYHLERLI..NFGLKVAVVRQTETA...ALK 43 SC----........YFE....HNFLNASVPSYRIDYHLERLI..NFGLKVAVVRQTETA...ALK 44 AF----........-MR....GSYAHAGFPEHAASKFADQLM..NHGYKVARIEQTETP...QML 45 TY----........-MR....GEFAHSGFPEISFDKMSTILV..DRGFKVARVEQTETP...DMM 46 VF----........-MK....GNWAHSGFPEIAFGRYSDSLV..QKGYKVARVEQTETP...EMM 47 VF----........-MK....GNWAHSGFPEIAFGRYSDSLV..QKGYKVARVEQTETP...EMM 48 VF----........-MK....GNWAHSGFPEIAFGRYSDSLV..QKGYKVARVEQTETP...EMM 49 VF----........-MK....GNWAHSGFPEIAFGRYSDSLV..QKGYKVARVEQTETP...EMM 50 VF----........-MK....GNWAHSGFPEIAFGRYSDSLV..QKGYKVARVEQTETP...EMM 51 IF----........-MK....GNWAHSGFPEIAFGRFSDSLV..QKGYKVARVEQTETP...EMM 52 IF----........-MK....GNWAHSGFPEIAFGRFSDSLV..QKGYKVARVEQTETP...EMM 53 KMTV--........SGV....GKCRQVGISESGIDDAVDKLI..ARGYKVGRIEQMESA...NQA 54 KMTV--........SGV....GKCRQVGISESGIDDAVDKLI..ARGYKVGRIEQMESA...NQA 55 ------........---....---------------------..---------------...--- 56 KMTM--........SGV....GKCRQVGISESGIDEAVQKLL..ARGYKVGRIEQLETS...DQA 57 YA----........HMD....HSFMTASVPTFRLNVHVRGLV..NAGYKVGVVKQTETA...AIK 58 ------........---....---------------------..---------------...--- 59 ------........---....---------------------..---------------...--- 60 QY----........-MK....GEQPHCGFPEKNFSVNIEKLV..RKGYRVLVVEQTETP...DQL 61 QY----........-MK....GEQPHCGFPEKNFSVNIEKLV..RKGYRVLVVEQTETP...DQL 62 KLT---........-DR....VNMKMVGIPEASFDYWASQFI..AKGYRIARVDQLETA...LGK 63 KI--AG........GGR....ANMQLAGIPEMSFEYWAAQFI..QMGYKVAKVDQRESM...LAK 64 KI--AG........GGR....ANMQLAGIPEMSFEYWAAQFI..QMGYKVAKVDQRESM...LAK 65 TLT---........-KR....NGTPMCGVPVHTARTHIARLL..KHGKKVALCEQVSHP...-VP 66 VLTHKT........SKD....FTTPMAGIPLRAFEAYAERLL..KMGFRLAVADQVEPA...EEA 67 VLTHKT........SKD....FTTPMAGIPLRAFEAYAERLL..KMGFRLAVADQVEPA...EEA 68 VLTHKT........SKD....FTTPMAGIPIRAFDAYAERLL..KMGFRLAVADQVEPA...EEA 69 VLTHKT........SKD....FTTPMAGIPIRAFDAYAERLL..KMGFRLAVADQVEPA...EEA 70 VLTHKT........SKD....FTTPMAGIPIRAFDAYAERLL..KMGFRLAVADQVEPA...EEA 71 VLTHKT........SKD....FTTPMAGIPIRAFDAYAERLL..RMGFGLAVADQVEPA...EEA 72 ILTSKE........GGKei..GRVAMTGVPHHALDRYARQLV..EKGYAVAICDQVEDA...AEA 73 ILTSKE........GGKei..GRVAMTGVPHHALDRYARQLV..EKGYAVAICDQVEDA...AEA 74 TLT---........-QR....QGIPMSGIPVSTVDTYVDRLI..GKGFKVAVAEQFGEP...AKE 75 TLT---........-QR....QGIPMSGIPVSTVDTYVDRLI..GKGFKVAVAEQFGEP...AKE 76 TLT---........-QR....QNVPMSGIPATCLDGYVDRLV..SRGFKVAIAEQADNT...EGS 77 ------........---....---------------------..---------------...--- 78 ------........---....---------------------..---------------...--- 79 TLT---........-QR....QNIPMSGIPAAYLDGYVDRLV..SRGFKIAIAEQADNS...EGG 80 TLTTRGq.......VDG....EPVKMAGVPFHAAEQYLARLV..KLGKSVAICEQVGEV...GAG 81 TLTTRGq.......VDG....EPVKMAGVPFHAAEQYLARLV..KLGKSVAICEQVGEV...GAG 82 SLTKRGq.......SAG....QPIPMAGMPYHAVEGYLAKLV..QLGESVAICEQIGDP...TTS 83 SLTKRSa.......SAG....EPIPMAGIPYHAVENYLAKLV..NQGESVAICEQIGDP...ATS 84 SLTKRGa.......SAG....EPIPMAGIPYHAVENYLAKLV..NQGESVAICEQIGDP...ATS 85 SLTKRGa.......SAG....EPIPMAGIPYHAVENYLAKLV..NQGESVAICEQIGDP...ATS 86 SLTKRGa.......SAG....EPIPMAGIPHHAVENYLAKLV..NQGESVAICEQIGDP...ATS 87 SLTKRGa.......SAG....EPIPMAGIPHHAVENYLAKLV..NQGESVAICEQIGDP...ATS 88 TLTARGq.......SAG....KSIPMAGIPFHSVEGYLAKLV..KLGESVAICEQIGDP...ATT 89 TLTARGq.......SGG....KAIPMAGIPFHSAEGYLAKLV..KLGESVAICEQIGDP...ATS 90 TLTARGq.......SGG....KAIPMAGIPFHSAEGYLAKLV..KLGESVAICEQIGDP...ATS 91 ------........---....---------------------..---------------...--- 92 ------........---....---------------------..---------------...--- 93 ------........---....---------------------..---------------...--- 94 ------........---....---------------------..---------------...--- 95 ------........---....---------------------..---------------...--- 96 ------........---....---------------------..---------------...--- 97 ------........---....---------------------..---------------...--- 98 ------........---....---------------------..---------------...--- 99 ------........---....---------------------..---------------...--- 100 ------........---....---------------------..---------------...--- 101 TLTKRGq.......HMG....QEIPMCGVPVHAADDYLQKLI..ASGYRVAVCEQVEDP...AEA 102 TLTQRGs.......SGG....APIPMAGVPVHAYEGYLARLI..ALGESVAICEQIGDP...GLA 103 ------........---....---------------------..---------------...--- 104 ------........---....---------------------..---------------...--- 105 TLTKRDa.......KKE....NPIPMCGVPYHSADSYIDTLV..NNGYKVAICEQMEDP...KQT 106 TLTSRDg.......GAA....EKIPMCGVPYHSASAYIEQLI..KKGYKVAICEQTEDP...KAA 107 TLTSRDg.......GAA....EKIPMCGVPYHSASAYIEQLI..KKGYKVAICEQTEDP...KAA 108 SLTSRNk.......NAD....NPIPMAGVPYHSAQQYIDVLI..EQGYKVAIAEQMEDP...KQA 109 VLTSRPag......KGR....ERIPMCGVPYHSANNYIAKLV..NKGYKVAICEQVEDP...SKA 110 VLTSRPag......KGK....ERIPMCGVPYHSANSYIAKLV..NKGYKVAICEQVEDP...SKA 111 VLT---........-RR....QDAPMAGIPYHALNTYLKKLV..EAGYKVAICDQMEEP...SKS 112 VLT---........-RR....QDAPMAGIPYHALNTYLKKLV..EAGYKVAICDQMEEP...SKS 113 ALTKRGk.......NCE....EEIPMCGVPYHALEHYLTKLI..EENYKVAICDQLETP...EEA 114 TQSVLKncq10takNFH....EPTKYVTVSLQVLATLLKLCLl.DLGYKVEIYDK----...--- 115 TQSVLKncq10takNFH....EPTKYVTVSLQVLATLLKLCLl.DLGYKVEIYDK----...--- 116 TNGVIKylg.....SGN....KKLESVVLSKMNFESVVKDLLl.VRQYRVEVYKNKSGG...KYS 117 TQGVIK........YMGpagaKTLQTVVLSKMNFESFVKDLLl.VRHYRVEVYKNKAGN...KAS 118 TQGVIKymgp....AGS....KTLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNKAGN...KAS 119 TQGVIKymgp....AGS....KTLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNKAGN...KAS 120 TQGVIK........YMGpagaKNLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNRAGN...KAS 121 TQGVIK........YMGpagaKNLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNRAGN...KAS 122 TQGVIK........YMGpagaKNLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNRAGN...KAS 123 TQGVIK........YMGpagaKNLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNRAGN...KAS 124 TQGVIK........YMGpagaKNLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNRAGN...KAS 125 TQGVIK........YMGpagaKNLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNRAGN...KAS 126 TQGVIK........YMGpagaKNLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNRAGN...KAS 127 TTSVIRqlgr....SDH....TGLPSVTMTVTVFRQFLREALf.KLGKRIEIW------...ASP 128 ------........---....---------------------..---------------...--- 129 TTSVLKh.......HNV....SNTSYCNLSPSLFIKFAEDVLs.NLAKRVEIW------...GAN 130 TTSVLKh.......HNV....SNTSYCNLSPSLFIKFAEDVLs.NLAKRVEIW------...GAN 131 TMSALRqlg.....SSS....DGILSASVSKAMFETIARNILleRTDCTLELYEGSGS-...--- 132 ------........---....---------------------..---------------...--- 133 TTTALRqlg.....SGS....NALSSVSISRNMFETIARDLLleRNDHTVELYEGSGS-...--- 134 TTTALRqlg.....SGS....NALSSVSISRNMFETIARDLLleRNDHTVELYEGSGS-...--- 135 STAFIGallpd...DKK....ETLQFVSMSKGNFELAVRELLl.VRNYRVEVY------...--V 136 STAFIGallpd...DKK....ETLQFVSMSKGNFELAVRELLl.VRNYRVEVY------...--V 137 STAFIGallpd...DKK....ETLQFVSMSKGNFELAVRELLl.VRNYRVEVY------...--V 138 ------........---....---IMNDISEDLEFRFLKRLId.DVKPTLIIANRSQDL...EFI 139 ------........---....---IMNDISEDLEFRFLKRLId.DVKPTLIIANRSQDL...EFI 140 ------........---....---IMNDISEDLEFRFLKRLId.DVKPTLIIANRSQDL...EFI 141 ------........---....---------------------..---------------...--- 142 ------........---....--GPRSGIPSASFP-------..---------------...--- 143 ------........---....--GPRSGIPSASFP-------..---------------...--- 144 ------........---....---------------------..---------------...--- 145 ------........---....---------------------..---------------...--- 146 ------........---....---------------------..---------------...--- 147 ------........---....---------------------..---------------...--- 148 ------........---....---------------------..---------------...--- 149 ------........---....---------------------..---------------...--- 150 TPPIEQvas11iisLGK....RSLLQMGFPVYSLTTHLSTLL..DKGWTVIVIDELVTN...--K 151 TPPIEQvas11iisLGK....RSLLQMGFPVYSLTTHLSTLL..DKGWTVIVIDELVTN...--K 110 120 130 1 | | | 1 -........---EWKMTKRGSPGNT........VDfeqEIGV....SDQAPILAIYIHpgdd... 2 G........GPLEREVVEVITPGVI........ID...EDFLn...DDINNYLVAISDy...... 3 Dnea.....NKFYRRVTRIVTPGTF........ID...EAFEn...LRENTYLLNIEFpen11ad 4 Dnea.....NKFYRRVTRIVTPGTF........ID...EAFEn...LRENTYLLNIEFpen11ad 5 -........------VTRVITPGTL........ID...ENFMn...PYESNYILTVVFdpn22cf 6 -........----------------........--...----....------------....... 7 K........NMYIRSVTRVITPGTL........ID...ENFMn...PYESNYILTVVFdpn22cf 8 -........----------------........--...----....------------....... 9 -........----------------........--...----....------------....... 10 -........----------------........--...----....------------....... 11 -........----------------........--...----....------------....... 12 -........----------------........--...----....------------....... 13 -........----------------........--...----....------------....... 14 -........----------------........--...----....------------....... 15 -........----------------........--...----....------------....... 16 -........----------------........--...----....------------....... 17 -........----------------........--...----....------------....... 18 -........----------------........--...----....------------....... 19 -........----------------........--...----....------------....... 20 -........----------------........--...----....------------....... 21 -........----------------........--...----....------------....... 22 -........----------------........--...----....------------....... 23 -........----------------........--...----....------------....... 24 -........----------------........--...-LLG....PSIDCVLCCIYEvprdi.. 25 -........----------------........--...-LLG....PSIDCVLCCIYEvprdi.. 26 -........----------------........--...----....-------MS---vyspkad 27 -........----------------........--...-AIS....AHSPSVIVAVVEgrgla.. 28 -........----------------........--...-AIS....AHSPSVIVAVVEgrgla.. 29 -........----------------........--...NTTT....KNVNSDVVIVVMegrgsc. 30 KhdpgasksSVFERKISNVFTKATFgvnstfv.LR...GKRI....LGDTNSIWALSRdvhqgk. 31 KhdpgasksSVFERKISNVFTKATFgvnstfv.LR...GKRI....LGDTNSIWALSRdvhqgk. 32 Shganrt..GPFFRGLSALYTKATLeaa10ggcGG...EEGF....GSQSNFLVCVVDerv16ms 33 Shganrt..GPFFRGLSALYTKATLeaa10ggcGG...EEGF....GSQSNFLVCVVDerv16ms 34 Shganrt..GPFFRGLSALYTKATLeaa10ggcGG...EEGF....GSQSNFLVCVVDerv16ms 35 Aigdnks..SVFSRKLTALYTKSTLige16svnID...EVMT....DTSTNYLLCIYEeke11kk 36 Aigdnks..SVFSRKLTALYTKSTLige16svnID...EVMT....DTSTNYLLCIYEeke11kk 37 Aigdnks..SVFSRKLTALYTKSTLige16svnID...EVMT....DTSTNYLLCIYEeke11kk 38 Aigdnks..SVFSRKLTALYTKSTLige16svnID...EVMT....DTSTNYLLCIYEeke11kk 39 Aigdnks..SVFSRKLTALYTKSTLige16svnID...EVMT....DTSTNYLLCIYEeke11kk 40 Aigdnrs..SLFSRKLTALYTKSTLige16avnVD...EIMT....DTSTSYLLCISEnke11kk 41 Aigdnrs..SLFSRKLTALYTKSTLige16avnVD...EIMT....DTSTSYLLCISEnke11kk 42 Stsssrn..TLFDRRVARVLTKGTT........LD...DSFF....RFEQTQHGTLQAsqf19ks 43 Stsssrn..TLFDRRVARVLTKGTT........LD...DSFF....RFEQTQHGTLQAsqf19ks 44 Eern10tkeKVVRREVCRVTSNGTRtyg11dlgSA...SSTL....DPTAKHLLAIKEfhnpetg 45 Terc12kfdKVVAREICQITNRGTQ........VF...GSQCkigpNHQPNYMLAIVEkdegt.. 46 Earc13kydRVVRREICRIITKGTQtysv....LE...GDPS....ENYSKYLLSLKEkeedssg 47 Earc13kydRVVRREICRIITKGTQtysv....LE...GDPS....ENYSKYLLSLKEkeedssg 48 Earc13kydRVVRREICRIITKGTQtysv....LE...GDPS....ENYSKYLLSLKEkeedssg 49 Earc13kydRVVRREICRIITKGTQtysv....LE...GDPS....ENYSKYLLSLKEkeedssg 50 Earc13kydRVVRREICRIITKGTQtysv....LE...GDPS....ENYSKYLLSLKEkeedssg 51 Earc13kfdRVVRREICRIITKGTQtysv....LD...GDPS....ENYSRYLLSLKEkeeetsg 52 Earc13kfdRVVRREICRIITKGTQtysv....LD...GDPS....ENYSRYLLSLKEkeeetsg 53 Kargvh...SVIERKLVHVSTPSTA........VD...NIGT....DAVHLLALKEVTlassg.. 54 Kargvh...SVIERKLVHVSTPSTA........VD...NIGT....DAVHLLALKEVTlassg.. 55 -........----------------........--...----....------------....... 56 Kargan...TIIPRKLVQVLTPSTA........SE...GNIG....PDAVHLLAIKEIkmelqkc 57 Shganra..GPFFRGLSGLYTKATLeaa10ggcVG...EEGF....GGQSNFLVCVVDerv17as 58 -........----------------........--...----....------------....... 59 -........----------------........--...----....------------....... 60 Eqrr10skdKVVKREVCAVVTKGTL........TD...GEMLlt..NPDASYLMALTEgge10pt 61 Eqrr10skdKVVKREVCAVVTKGTL........TD...GEMLlt..NPDASYLMALTEgge10pt 62 Eikd11keeKVVQRGLTQVLTSGTL........VD...EAMLt...SDLSTYCMAIKEslqsdne 63 Emregsk..GIVKRELQCILTSGTL........TD...GDMLh...SDLATFCLAIREepg21kl 64 Emregsk..GIVKRELQCILTSGTL........TD...GDMLh...SDLATFCLAIREepg21kl 65 G........ELTQRKVIEIISPGTA........VE...DDFLs...QGFSQYLATVCAs...... 66 E........GLVRREVTQLLTPGTL........LQ...ESLL....PREANYLAAIAT....... 67 E........GLVRREVTQLLTPGTL........LQ...ESLL....PREANYLAAIAT....... 68 E........GLVRREVTQLLTPGTL........TQ...EALL....PREANYLAAIAT....... 69 E........GLVRREVTQLLTPGTL........TQ...EALL....PREANYLAAIAT....... 70 E........GLVRREVTQLLTPGTL........TQ...EALL....PREANYLAAIAT....... 71 E........GLVRREVTQLLTPGTL........TQ...EALL....PREANYLAAIAT....... 72 Qaek.....RMVERQVTKLLTPGTL........TD...DSMLp...AKRNNFLAAIAMv...... 73 Qaek.....RMVERQVTKLLTPGTL........TD...DSMLp...AKRNNFLAAIAMv...... 74 Keskki...GPMARDIQRFVTPGTL........LS...STLLq...EKFNNYIVAINRi...... 75 Keskki...GPMARDIQRFVTPGTL........LS...STLLq...EKFNNYIVAINRi...... 76 K........GLVPRTINRLITPGAL........LS...SSLLp...EKANNYVLAINQv...... 77 -........----------------........--...----....------------....... 78 -........----------------........--...----....------------....... 79 K........GLVPRTINRLITPGAL........LS...SSLLp...EKANNYIIAISQv...... 80 K........GPVERKVVRIVTPGTL........TD...SALLe...DKETNRIVAVSPd...... 81 K........GPVERKVVRIVTPGTL........TD...SALLe...DKETNRIVAVSPd...... 82 K........GPVERQIVRIVTPGTV........SD...EALLp...ERQDNLIAAVYQe...... 83 K........GPVERKVVRIVTPGTI........SD...EALLq...ERQDNLLAAIWQd...... 84 K........GPVERKVVRIVTPGTI........SD...EALLq...ERQDNLLAAIWQd...... 85 K........GPVERKVVRIVTPGTI........SD...EALLq...ERQDNLLAAIWQd...... 86 K........GPVERKVVRIVTPGTI........SD...EALLq...ERQDNLLAAIWQd...... 87 K........GPVERKVVRIVTPGTI........SD...EALLq...ERQDNLLAAIWQd...... 88 K........GPVERQVVRIITPGTV........SD...EALL....DERRDNLLAAVVgd..... 89 K........GPVERQVVRIITPGTV........SD...EALL....DERRDNLLAAILgd..... 90 K........GPVERQVVRIITPGTV........SD...EALL....DERRDNLLAAILgd..... 91 -........----------------........--...----....------------....... 92 -........----------------........--...----....------------....... 93 -........----------------........--...----....------------....... 94 -........----------------........--...----....------------....... 95 -........----------------........--...----....------------....... 96 -........----------------........--...----....------------....... 97 -........----------------........--...----....------------....... 98 -........----------------........--...----....------------....... 99 -........----------------........--...----....------------....... 100 -........----------------........--...----....------------....... 101 Kkrgsk...SVVRRDVVRLVTPGTI........TE...DKLLs...PSESNYLMALARirsgs.. 102 K........GLVERKVVRIVTPGTI........TD...EVLLe...ERRDTLLMALSRs...... 103 -........----------------........--...----....------------....... 104 -........----------------........--...----....------------....... 105 K........GMVRREVVRIVTPGTV........ME...QGGVd...DKQNNYILSFVMn...... 106 K........GVVKREVVQLITPGTV........MD...GKGIh...ESENNFIASVSAc...... 107 K........GVVKREVVQLITPGTV........MD...GKGIh...ESENNFIASVSAc...... 108 V........GVVKREVVQVITPGTV........VD...SSKP....DSQNNFLVSIDRe...... 109 K........GIVKRDVIRVITPGTF........FE...RE--....---TGGLCSLYRk...... 110 K........GIVKREVVRVITPGTF........FE...RDTG....----GLASLYK-k...... 111 K........KLIRREVTRVVTPGSI........VE...DEFL....SETNNYMAVVSEe...... 112 K........KLIRREVTRVVTPGSI........VE...DEFL....SETNNYMAVVSEe...... 113 Kkrdgyk..AVVTRDVTRIITPGTI........IE...ENLIs...VTEPNYLTSLVIpkn.... 114 -........---GWKLIKSASPGNI........EQ...VNEL....MNMNIDSSIIIAslk11qd 115 -........---GWKLIKSASPGNI........EQ...VNEL....MNMNIDSSIIIAslk11qd 116 Ken......---DWQLAFKASPGNL........TQf..EEIL....FGNNDMSTAVGVvgi10se 117 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMATSIGImgi10vd 118 Ken......---EWYLAFKASPGNL........SQf..EDIL....FGNNDMSASVGVmgi10vd 119 Ken......---EWYLAFKASPGNL........SQf..EDIL....FGNNDMSASVGVmgi10vd 120 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMSASIGVvgv10vd 121 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMSASIGVvgv10vd 122 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMSASIGVvgv10vd 123 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMSASIGVvgv10vd 124 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMSASIGVvgv10vd 125 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMSASIGVvgv10vd 126 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMSASIGVvgv10vd 127 S........GRMNWKVVKQASPGNL........QDv..EDELggq.FEGAPVILAV--kisakas 128 -........----------------........--...----....------------....... 129 S........AKTGFELLKQASPGNMqm......LE...DLLV....SENYQESTAISDssv17kq 130 S........AKTGFELLKQASPGNMqm......LE...DLLV....SENYQESTAISDssv17kq 131 -........---NWRLTKSGTPGNI........GSf..EDIL....FANNDMEDSPVIval10re 132 -........----------------........--...----....------------....... 133 -........---NWRLVKTGSPGNI........GSf..EDVL....FANNEMQDTPVVvsi10hd 134 -........---NWRLVKTGSPGNI........GSf..EDVL....FANNEMQDTPVVvsi10hd 135 K........NSSDWEIEYRGSPGNL........LQf..EDIL....FSNKEVLVGNSIisl11gg 136 K........NSSDWEIEYRGSPGNL........LQf..EDIL....FSNKEVLVGNSIisl11gg 137 K........NSSDWEIEYRGSPGNL........LQf..EDIL....FSNKEVLVGNSIisl11gg 138 Kfl......TTRYDPQEKIYEDGTT........EE...GTSE....DTVPTWDSSLAY....... 139 Kfl......TTRYDPQEKIYEDGTT........EE...GTSE....DTVPTWDSSLAY....... 140 Kfl......TTRYDPQEKIYEDGTT........EE...GTSE....DTVPTWDSSLAY....... 141 -........----------------........--...----....------------....... 142 -........----SPQPPMAGPGGI........EE...EDEE....EPAEIHLCVLWS....... 143 -........----SPQPPMAGPGGI........EE...EDEE....EPAEIHLCVLWS....... 144 -........----------------........--...----....ELAEIHLCVLWN....... 145 -........----------------........--...----....ELAEIHLCVLWN....... 146 -........----------------........--...----....------------....... 147 -........----------------........--...----....ELAEIHLCVLWN....... 148 -........-------------SSHdl......ID...DADMss..NDISLLLGLLIM....... 149 -........-------------SSHdl......ID...DADMss..NDISLLLGLLIM....... 150 S........GPKQRAVSQVYSPSCN........LE...DCPEl...----PYVLSIYFsq..... 151 S........GPKQRAVSQVYSPSCN........LE...DCPEl...----PYVLSIYFsq..... 40 150 160 170 180 | | | | | 1 .DNRVTLCAWDAGNVRIVISEYIDtps.FSQTEQC.IFGLCPTEyILVNE.....GSVA.....P 2 .KDYYSFSYIDLSTSSLGIMFYENgf..FEKLKRD.LEKYSPKE.IIVSE.....NFYY.....E 3 tSLKVGICWCDVSTGEIFVQQVY-....LRDLVSA.ITRIQPKE.ILLDE.....RLLE.....F 4 tSLKVGICWCDVSTGEIFVQQVY-....LRDLVSA.ITRIQPKE.ILLDE.....RLLE.....F 5 aDCKIGLSWLDLSTGEFFTQDSN-....LQRLAGD.LTRISPRE.IVLDE.....SLKS.....F 6 .-----------------------....-------.--------.-----.....----.....- 7 aDCKIGLSWLDLSTGEFFTQDSN-....LQRLAGD.LTRISPRE.IVLDE.....SLKS.....F 8 .-----------------------....YDLLIDMgLNRYHPVI.LNPDP.....GELD.....E 9 .-----------------------....-------.--------.-----.....----.....- 10 .-----------------------v...KEELEDF.LLKVKPI-.-----.....----.....- 11 .-----------------------....-------.--------.-----.....----.....- 12 .-----------------------....-------.--------.-----.....----.....- 13 .-----------------------....-------.--------.-----.....----.....- 14 .-----------------------....-------.--------.-----.....----.....- 15 .-----------------------....-------.--------.-----.....----.....- 16 .-----------------------....-------.--------.-----.....----.....- 17 .-----------------------....-------.--------.-----.....----.....- 18 .-----------------------....-------.--------.-----.....----.....- 19 .-----------------------....-------.--------.-----.....----.....- 20 .-----------------------....-------.--------.-----.....----.....- 21 .-----------------------....-------.--------.-----.....----.....- 22 .-----------------------....-------.--------.-----.....----.....- 23 .-----------------------....-------.--------.-----.....----.....- 24 .STRIGLCIINCNTGQMYLSDFMDsqi.YIRVVHK.LQIYQPTE.ILIPS.....SSLA.....P 25 .STRIGLCIINCNTGQMYLSDFMDsqi.YIRVVHK.LQIYQPTE.ILIPS.....SSLA.....P 26 .SMDVGVSVLKLKTLELTLMSFCDsst.FVRTVNQ.IQVYEPTS.IILPE.....AQSH.....S 27 .RGEIGMASIDLKNPQIILSQFADntt.YAKVITK.LKILSPLE.IIMSN.....TACA.....V 28 .RGEIGMASIDLKNPQIILSQFADntt.YAKVITK.LKILSPLE.IIMSN.....TACA.....V 29 .EGHIGIALHDTCFPEIHLCEFVDsre.YTTLKTM.INVHEAFD.IVIQN.....GNEE.....R 30 .VAKYSLISVNLNNGEVVYDEFEEpnlaDEKLQIR.IKYLQPIE.VLVNT.....DDLP.....L 31 .VAKYSLISVNLNNGEVVYDEFEEpnlaDEKLQIR.IKYLQPIE.VLVNT.....DDLP.....L 32 fDVRVGVVGVEISTGEVVYEEFNDnfm.RSGLEAV.ILSLSPAE.LLLGQ.....PLSQ.....Q 33 fDVRVGVVGVEISTGEVVYEEFNDnfm.RSGLEAV.ILSLSPAE.LLLGQ.....PLSQ.....Q 34 fDVRVGVVGVEISTGEVVYEEFNDnfm.RSGLEAV.ILSLSPAE.LLLGQ.....PLSQ.....Q 35 gNLSVGVVGVQPATGEVVFDCFQDsas.RLELETR.ISSLQPVE.LLLPS.....DLSE.....P 36 gNLSVGVVGVQPATGEVVFDCFQDsas.RLELETR.ISSLQPVE.LLLPS.....DLSE.....P 37 gNLSVGVVGVQPATGEVVFDCFQDsas.RLELETR.ISSLQPVE.LLLPS.....DLSE.....P 38 gNLSVGVVGVQPATGEVVFDCFQDsas.RLELETR.ISSLQPVE.LLLPS.....DLSE.....P 39 gNLSVGVVGVQPATGEVVFDCFQDsas.RLELETR.ISSLQPVE.LLLPS.....DLSE.....P 40 gNIFIGIVGVQPATGEVVFDSFQDsas.RSELETR.MSSLQPVE.LLLPS.....ALSE.....Q 41 gNIFIGIVGVQPATGEVVFDSFQDsas.RSELETR.MSSLQPVE.LLLPS.....ALSE.....Q 42 gRVQVGLIAIQLSSGTTVYDHFQDdfl.RSELQTR.LSHFQPCE.LIYSN.....KLSS.....E 43 gRVQVGLIAIQLSSGTTVYDHFQDdfl.RSELQTR.LSHFQPCE.LIYSN.....KLSS.....E 44 .KSSYGVCMIDTTTAHIRIGQFEDddy.RSQLRTL.LANVIVVQ.AIVER.....GSIS.....S 45 .CSRYGVCFIDTSIGDFHLGEFEDdkn.CSRLLTL.VSHHMPVL.FLNEK.....SALS.....Q 46 hTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTL.VAHYPPVQ.VLFEK.....GNLS.....K 47 hTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTL.VAHYPPVQ.VLFEK.....GNLS.....K 48 hTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTL.VAHYPPVQ.VLFEK.....GNLS.....K 49 hTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTL.VAHYPPVQ.VLFEK.....GNLS.....K 50 hTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTL.VAHYPPVQ.VLFEK.....GNLS.....K 51 hTRVYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTL.VAHYPPVQ.ILFEK.....GNLS.....T 52 hTRVYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTL.VAHYPPVQ.ILFEK.....GNLS.....T 53 .FQVFGFAFLDYAALKIWVGSVQDdds.SAALGAL.LMQVSPRE.LIYET.....SGIS.....K 54 .FQVFGFAFLDYAALKIWVGSVQDdds.SAALGAL.LMQVSPRE.LIYET.....SGIS.....K 55 .-----------------------....-------.--------.-----.....----.....- 56 .STVYGFAFVDCAALRFWVGSISDdas.CAALGAL.LMQVSPKE.VLYDS.....KGLS.....R 57 fDVRVGVVGVEISTGEVVHGEFNDnfm.RSGLEAV.I-------.-----.....----.....- 58 .-----------------------....-------.--------.-----.....----.....- 59 .-----------------------....-------.--------.-----.....----.....- 60 aEHNFGVCLVDVATQKIILGQFKDdqd.CSALSCL.LSEMRPVE.IIKPA.....KVLS.....Y 61 aEHNFGVCLVDVATQKIILGQFKDdqd.CSALSCL.LSEMRPVE.IIKPA.....KVLS.....Y 62 .EPSFGICFIDTSTGGFHMCEFTDdih.RTKLDTL.LTQVRPKE.LILEK.....SKIS.....Q 63 nTKIFGAAFIDTATGELQMLEFEDdse.CTKLDTL.MSQVRPME.VVMER.....NNLS.....T 64 nTKIFGAAFIDTATGELQMLEFEDdse.CTKLDTL.MSQVRPME.VVMER.....NNLS.....T 65 .DATVAFSYLEVSTGAFFITSFPRaea.ADALQKE.FGRVQPSE.VLLSA.....SVLR.....S 66 .GDGWGLAFLDVSTGEFKGTVLKS....KSALYDE.LFRHRPAE.VLLAP.....ELLE.....N 67 .GDGWGLAFLDVSTGEFKGTVLKS....KSALYDE.LFRHRPAE.VLLAP.....ELLE.....N 68 .GDGWGLAFLDVSTGEFKGTLLKS....KSALYDE.LFRHRPAE.VLLAP.....ELRE.....N 69 .GDGWGLAFLDVSTGEFKGTLLKS....KSALYDE.LFRHRPAE.VLLAP.....ELRE.....N 70 .GDGWGLAFLDVSTGEFKGTLLKS....KSALYDE.LFRHRPAE.VLLAP.....ELRE.....N 71 .GDGWGLAFLDVSTGEFKATLLKS....KSALYDE.LFRHRPAE.VLLAP.....ELRE.....N 72 .EDKWGLAHADISTGEFFTCQSSN....LDDLAVE.LLRLQPSE.VLIPT.....SAPD.....I 73 .EDKWGLAHADISTGEFFTCQSSN....LDDLAVE.LLRLQPSE.VLIPT.....SAPD.....I 74 .GSLFGFACLDLSTGSFFIEECEN....TKELVDE.ICRLAPSE.VLSCN.....KFYNk....E 75 .GSLFGFACLDLSTGSFFIEECEN....TKELVDE.ICRLAPSE.VLSCN.....KFYNk....E 76 .GSLYGLSCLDLSIGTFLVAEYDN....TKDLIEA.ICRLAPTE.LLSHA.....KFYQk....N 77 .-----------------------....-------.--------.-----.....----.....- 78 .-----------------------....-------.--------.-----.....----.....- 79 .GSLYGLSCLDLSTGTFLVAEYDN....TKDLIEA.VYRLAPTE.LLSHA.....KFYQk....N 80 .KKYIGLAWASLQSGEFKTKLTT-....VDKLDDE.LARLQAAE.ILLPD.....SKNA.....P 81 .KKYIGLAWASLQSGEFKTKLTT-....VDKLDDE.LARLQAAE.ILLPD.....SKNA.....P 82 .KEKFGLATLDMTSGRFQLCEPAD....KETLRAE.LQRIAPVE.LLYCE.....EFNE.....M 83 .SKGFAYATLDISSGRFRLSEPAD....RETMAAE.LQRTNPAE.LLYAE.....DFAE.....M 84 .SKGFGYATLDISSGRFRLSEPAD....RETMAAE.LQRTNPAE.LLYAE.....DFAE.....M 85 .SKGFGYATLDISSGRFRLSEPAD....RETMAAE.LQRTNPAE.LLYAE.....DFAE.....M 86 .GKGYGYATLDISSGRFRLSEPAD....RETMAAE.LQRTNPAE.LLYAE.....DFAE.....M 87 .GKGYGYATLDISSGRFRLSEPAD....RETMAAE.LQRTNPAE.LLYAE.....DFAE.....M 88 .ERLFGLAILDITSGRFNVQEIQG....WENLLAE.LERLNPAE.LLYPD.....DWPA.....G 89 .ERLFGLAVLDITSGRFSVQEIKG....WETLLAE.LERLNPAE.LLIPD.....DWPQ.....G 90 .ERLFGLAVLDITSGRFSVQEIKG....WETLLAE.LERLNPAE.LLIPD.....DWPQ.....G 91 .-----------------------....-------.--------.-----.....----.....- 92 .-----------------------....-------.--------.-----.....----.....- 93 .-----------------------....-------.--------.-----.....----.....- 94 .-----------------------....-------.--------.-----.....----.....- 95 .-----------------------....-------.--------.-----.....----.....- 96 .-----------------------....-------.--------.-----.....----.....- 97 .-----------------------....-------.--------.-----.....----.....- 98 .-----------------------....-------.--------.-----.....----.....- 99 .-----------------------....-------.--------.-----.....----.....- 100 .-----------------------....-------.--------.-----.....----.....- 101 .EPAYALAWIDISTGIFRLAETA-....ESRLLAD.ILRIEPRE.LILPD.....TVFH.....D 102 .KNCYGLAWADLAGGRFLVNEVNS....EEALEAE.LARLEPAE.LLLPD.....EDAW.....P 103 .-----------------------....-------.--------.-----.....----.....- 104 .-----------------------....-------.--------.-----.....----.....- 105 .QPEIALSYCDVSTGELKVTHFND....EATLLNE.ITTINPNE.VVIND.....NISD.....N 106 .SNGYGLALSDLTTGENLAVLIER....LEDVISE.IYSVGARE.IVVSG.....SLDA.....D 107 .SNGYGLALSDLTTGENLAVLIER....LEDVISE.IYSVGARE.IVVSG.....SLDA.....D 108 .GNQFGLAYMDLVTGDFYVTGLLD....FTLVCGE.IRNLKARE.VVLGY.....DLSE.....E 109 .GKSYLVSYLNLSVGEFIGAKVK-....EEELIDF.LSKFNIRE.VLVKK.....GEKL.....P 110 .GNHYYVGYLNLAVGEFLGAKVK-....IEELLDL.LSKLNIKE.ILVKK.....GEKL.....P 111 .KGRYCTVFCDVSTGEVLVHESSD....EQETLDL.LKNYSISQ.IICPE.....HLKS.....S 112 .KGRYCTVFCDVSTGEVLVHESSD....EQETLDL.LKNYSISQ.IICPE.....HLKS.....S 113 .KKTASICCVDLSTSKIFVINVP-....ETEILNE.LARLKSRE.ILLSE.....NLKSs....N 114 gNCIIGVAFIDTTAYKVGMLDIVDnev.YSNLESF.LIQLGVKE.CLVQDltsnsNSNA.....E 115 gNCIIGVAFIDTTAYKVGMLDIVDnev.YSNLESF.LIQLGVKE.CLVQDltsnsNSNA.....E 116 gQRLVGVGYVDSTLRKLGVCEFPDndq.FSNLEAL.LVQIGPKE.CVMPG.....GETAg....D 117 gQRQVGVGDVDSTQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CILPG.....GETAg....D 118 gQRHVGVGYVDSTQRKLGLCEFPEndq.FSNLEAL.LIQIGPKE.CVLPG.....GETTg....D 119 gQRHVGVGYVDSTQRKLGLCEFPEndq.FSNLEAL.LIQIGPKE.CVLPG.....GETTg....D 120 gQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CVLPG.....GETAg....D 121 gQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CVLPG.....GETAg....D 122 gQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CVLPG.....GETAg....D 123 gQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CVLPG.....GETAg....D 124 gQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CVLPG.....GETAg....D 125 gQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CVLPG.....GETAg....D 126 gQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CVLPG.....GETAg....D 127 eARTVGVCFADASVRELGVSEFLDndl.YSNFEAL.LIQLGVKE.CIVTQ.....DKGEkekdpE 128 .-----------------------....-------.--------.-----.....----.....- 129 dQRIIGVAFIDPILKKLGVSEFVDsda.YTNFEAL.IVQVGAKE.CIISQ.....SGHE.....S 130 dQRIIGVAFIDPILKKLGVSEFVDsda.YTNFEAL.IVQVGAKE.CIISQ.....SGHE.....S 131 sQLYVGLSFLDMTNRKLGLAEFPEdsr.FTNVESA.LVALGCKE.CLLPA.....DCEKsi...D 132 .-----------------------....-------.--------.-----.....----.....- 133 gRCVIGMAYVDLTRRVLGLAEFLDdsr.FTNLESS.LIALGAKE.CIFPA.....ESGKsn...E 134 gRCVIGMAYVDLTRRVLGLAEFLDdsr.FTNLESS.LIALGAKE.CIFPA.....ESGKsn...E 135 gQRRVGVASVEQNDCKFQLLEFLDddf.FTELEAT.VVLLGPKE.CLLPS.....IEGE.....Y 136 gQRRVGVASVEQNDCKFQLLEFLDddf.FTELEAT.VVLLGPKE.CLLPS.....IEGE.....Y 137 gQRRVGVASVEQNDCKFQLLEFLDddf.FTELEAT.VVLLGPKE.CLLPS.....IEGE.....Y 138 .ST------------DETTAEKEE....KEEDEDD.DDEGLPAK.LNKLP.....NNFF.....R 139 .ST------------DETTAEKEE....KEEDEDD.DDEGLPAK.LNKLP.....NNFF.....R 140 .ST------------DETTAEKEE....KEEDEDD.DDEGLPAK.LNKLP.....NNFF.....R 141 .-----------------------....-------.--------.-----.....----.....- 142 .SGYLGIAYYDTSDSTIHFMPDAPdhesLKLLQRV.LDEINPQS.VVTSA.....KQDE.....A 143 .SGYLGIAYYDTSDSTIHFMPDAPdhesLKLLQRV.LDEINPQS.VVTSA.....KQDE.....A 144 .SGYLGIAYYDTSDSTIHFMPDAPdhesLKLLQRV.LDEINPQS.VVTSA.....KQDE.....N 145 .SGYLGIAYYDTSDSTIHFMPDAPdhesLKLLQRV.LDEINPQS.VVTSA.....KQDE.....N 146 .-----------------------....-------.--------.-----.....----.....- 147 .SGYLGIAYYDTSDSTIHFMPDAPdhesLKLLQRV.LDEINPQS.VVTSA.....KQDE.....N 148 .EANPTVCLVPARLEDWIFDYIKT....KCDEINC.RLELQPIK.RFKKW.....DLLQ.....S 149 .EANPTVCLVPAFLEDWIFDYIKT....KCDEINC.RLELQPIK.FFKKW.....DLLQ.....S 150 .DDLLGITLFSAMNGHSIIFPVSWtd..RDKVTRL.LISYHIRE.IVIWA.....DSGV.....C 151 .DQLLGITLFSAMNGHSIIFPVSWtd..RDKVTRL.LISYHIRE.IVIWA.....DSGV.....C 190 200 210 220 230 | | | | | 1 KAKKIA...SMFTRMEVHNKQQLKPKsqw14ldyKDEAEKQNENIKECLQILHSNAA.D...... 2 YSEKLN...LSRFLINRVPTWHLDKDiai19slgFDEEKPYYISIFLIINHIKNNLK.N...... 3 HIESGT...WYPELVELKKFFIKYQKmps31iqfQTFTQKELAALRNTLIYVSNHLP.D...... 4 HIESGT...WYPELVELKKFFIKYQKmps31iqfQTFTQKELAALRNTLIYVSNHLP.D...... 5 TTHPIY...SFIQERKYFLSYVENRYqsl19sfiKYCTKLEVTAGCTLISYIADRLQ.N...... 6 ------...-----------------........-----------------------.-...... 7 TTHPIY...SFIQERKYFLSYVENRYqsl19sfiKYCTKLEVTAGCTLISYIADRLQ.N...... 8 YELIIY...VYSEGMLELEDTFSTIMv.......TADSDKHEIVPECVLNYF-----.-...... 9 ------...-----------------........--------------IKFRKEFLG.D...... 10 ------...-----------------........---------------KFRREFLD.D...... 11 ------...-----------------........-----------------------.-...... 12 ------...-----------------........-----------------------.-...... 13 ------...-----------------........-----------------------.-...... 14 ------...-----------------........-----------------------.-...... 15 ------...-----------------........-----------------------.-...... 16 ------...-----------------........-----------------------.-...... 17 ------...-----------------........-----------------------.-...... 18 ------...-----------------........-----------------------.-...... 19 ------...-----------------........-----------------------.-...... 20 ------...-----------------........-----------------------.-...... 21 ------...-----------------........-----------------------.-...... 22 ------...-----------------........-----------------------.-...... 23 ------...-----------------........-----------------------.-...... 24 TVSKLA...TMIKFNVAETVKIEEGSrkc29ieeIIDKTFALCAASAAISYMEEIIS.Kssrnln 25 TVSKLA...TMIKFNVAETVKIEEGSrkc29ieeIIDKTFALCAASAAISYMEEIIS.Kssrnln 26 QIEKLK...YIIHSNISDKVRERFMKakv27gqvISNRKLSLAAANACIDYCVSTKMfR...... 27 GNSTKL...FTLITENFKNVNFTTIQrky27lmeVQSKYYCLAAVAALLKYVEFIQN.S...... 28 GNSTKL...FTLITENFKNVNFTTIQrky27lmeVQSKYYCLAAVAALLKYVEFIQN.S...... 29 GSTKLL...GEALMTAFPEASLQSISsky27segCLRRTLALGALAVLLKYIHETRC.V...... 30 HVAKFF...KDISCPLIHKQEYDLEDhvv12nekIQLSPSLIRLVSKLYSHMVEYNN.E...... 31 HVAKFF...KDISCPLIHKQEYDLEDhvv12nekIQLSPSLIRLVSKLYSHMVEYNN.E...... 32 TEKFLV...AHAGPTSNVRVERASLDcfs46htiMNMPHLTVQALALTFCHLKQFGF.E...... 33 TEKFLV...AHAGPTSNVRVERASLDcfs46qtiMNMPHLTVQALALTFCHLKQFGF.E...... 34 TEKFLV...AHAGPTSNVRVERASLDcfs46htiMNMPHLTVQALALTFCHLKQFGF.E...... 35 TEMLIQ...RATNVRLKTVRKLKTPFlfl55sgvINLEKPVICALAAVIRYLKEFNL.E...... 36 TEMLIQ...RATNVRL----------........-----------------------.-...... 37 TEMLIQ...RATNVSVRDDRIRVERMnnt34sgvINLEKPVICALAAVIRYLKEFNL.E...... 38 TEMLIQ...RATNVSVRDDRIRVERMnnt34sgvINLEKPVICALAAVIRYLKEFNL.E...... 39 TEMLIQ...RATNVSVRDDRIRVERMnnt34sgvINLEKPVICALAAVIRYLKEFNL.E...... 40 TEALIH...RATSVSVQDDRIRVERMdni34sgiVNLEKPVICSLAAIIKYLKEFNL.E...... 41 TEALIH...RATSVSVQDDRIRVERMdni34sgiVNLEKPVICSLAAIIKYLKEFNL.E...... 42 SVALLN...HYVSTEKTCGRVVRVQHavq36ekvKSLHSLSIICLDMAISYLMEFSL.E...... 43 SVALLN...HYVSTEKTCGRVVRVQHavq36ekvKSLHSLSIICLDMAISYLMEFSL.E...... 44 TTKSII...NGILFSVPVEHLLPKKQfmt41pkpSTDWQLALSAFGAIFWYLRDSLI.Dvd.... 45 RTQQIV...RTVLGGILKEPVPGNGKhac44ltpNDNYKLALKALGQCIFFIHKCKL.Epk.... 46 ETKTIL...KSSLSCSLQEGLIPGSQfwd47ltpGEKSELALSALGGCVFYLKKCLI.Dqe.... 47 ETKTIL...KSSLSCSLQEGLIPGSQfwd47ltpGEKSELALSALGGCVFYLKKCLI.Dqe.... 48 ETKTIL...KSSLSCSLQEGLIPGSQfwd47ltpGEKSELALSALGGCVFYLKKCLI.Dqe.... 49 ETKTIL...KSSLSCSLQEGLIPGSQfwd47ltpGEKSELALSALGGCVFYLKKCLI.Dqe.... 50 ETKTIL...KSSLSCSLQEGLIPGSQfwd47ltpGEKSELALSALGGCVFYLKKCLI.Dqe.... 51 ETKTVL...KGSLSSCLQEGLIPGSQfwd45ltpGEESELALSALGGIVFYLKKCLI.Dqe.... 52 ETKTVL...KGSLSSCLQEGLIPGSQfwd45ltpGEESELALSALGGIVFYLKKCLI.Dqe.... 53 ETQRTI...RKYASAGSVKMQLTPLSgid33ldcTMNQDVVICALGGLIGHLTRLMLhD...... 54 ETQRTI...RKYASAGSVKMQLTPLSgid33ldcTMNQDVVICALGGLIGHLTRLMLhD...... 55 ------...-----------------........-----------------------.-...... 56 EAQKAL...RKYTLTGSTAVQLAPVPqvm34vdgLNECDVALSALGELINHLSRLKL.Ed..... 57 ------...-----------------........-----------------------.-...... 58 ------...-----------------........-----------------------.-...... 59 ------...-----------------........-----------------------.-...... 60 ATERTI...VRQTRNPLVNNLVPLSEfwd50ateDKNGSLALSALGGAIYYLRQAFL.Desll.. 61 ATERTI...VRQTRNPLVNNLVPLSEfwd50ateDKNGSLALSALGGAIYYLRQAFL.Desll.. 62 KSIRAI...KYCVSSSSIWNFIKPYTefw32ksyLSEKPLAISAFGALFWYLRQLKL.Dkd.... 63 LANKIV...KFNSAPNAIFNEVKAGEefy32syyDTGKKVGFSAFGGLLYYLKWLKL.Dkn.... 64 LANKIV...KFNSAPNAIFNEVKAGEefy32syyDTGKKVGFSAFGGLLYYLKWLKL.Dkn.... 65 LPELAA...ILSLYPRLVRTTGADALfnp23cltLLPHSPDLAAAGALIAYLEETTR.H...... 66 GAFLDE...FRKRFPVMLSEAPFEPE........GEGPLALRRARGALLAYAQRTQG.G...... 67 GAFLDE...FRKRFPVMLSEAPFEPE........GEGPLALRRARGALLAYAQRTQG.G...... 68 EAFVAE...FRKRFPVMLSEAPFEPQ........GEGPLALRRAQGALLAYARATQG.G...... 69 EAFVAE...FRKRFPVMLSEAPFEPQ........GEGPLALRRAQGALLAYARATQG.G...... 70 EAFVAE...FRKRFPVMLSEAPFEPQ........GEGPLALRRAQGALLAYARATQG.G...... 71 EAFVAQ...FRKRFPVMLSEAPFDPE........GEAPLALSRARGALLAYARATQG.G...... 72 RNILRP...GEPSEHIPKQLPTSFCYslr30gmgCEGLPLAIRAAGGLLEYIEDTQKaH...... 73 RNILRP...GEPSEHIPKQLPTSFCYslr30gmgCEGLPLAIRAAGGLLEYIEDTQKaH...... 74 TAIVMQ...LQQHLKLTLSTYADWAFehk22gfgLKGLVPAINAAGGLLSYIQDKLL.L...... 75 TAIVMQ...LQQHLKLTLSTYADWAFehk22gfgLKGLVPAINAAGGLLSYIQDKLL.L...... 76 EAVIKQ...LQQHLRITLSEYVSWAFeyq22gfgLQGLVPAINAAGALLSYIQDKLL.L...... 77 ------...-----------------........-----------------------.-...... 78 ------...-----------------........-----------------------.-...... 79 EPVVKQ...LQQHLRITLSEHVSWAFeyq22gfgLQGLVPAINAAGALLSYIQDKLL.L...... 80 QLQTAS...GVTRLNAWQFAADAGEKllt17gldGKEHAVAIGAAGALLNYIRLTQN.L...... 81 QLQTAS...GVTRLNAWQFAADAGEKllt17gldGKEHAVAIGAAGALLNYIRLTQN.L...... 82 AAIEHC...KGLRRRPIWEFELSTAItll16afgVEKSPLGLSAAGCLLQYAKETQR.T...... 83 SLIEGR...RGLRRRPLWEFEIDTARqql16gfgVENAPRGLCAAGCLLQYAKDTQR.T...... 84 SLIEGR...RGLRRRPLWEFEIDTARqql16gfgVENAPRGLCAAGCLLQYAKDTQR.T...... 85 SLIEGR...RGLRRRPLWEFEIDTARqql16gfgVENAPRGLCAAGCLLQYAKDTQR.T...... 86 ALIEGR...RGLRRRPLWEFEIDTARqql16gfgVENASRGLCAAGCLLQYVKDTQR.T...... 87 ALIEGR...RGLRRRPLWEFEIDTARqql16gfgVENASRGLCAAGCLLQYVKDTQR.T...... 88 LPLEKR...RGAHRRAPWDFDFDSAYksl16gfgCDGLGLAIGAAGCLLAYARETQR.T...... 89 LPAEKR...RGVRRRAPWDFDRDSAHksl16gfgCQNLTLAIGAAGCLLAYAKETQR.T...... 90 LPAEKR...RGVRRRAPWDFDRDSAHksl16gfgCQNLTLAIGAAGCLLAYAKETQR.T...... 91 ------...-----------------........-----------------------.-...... 92 ------...-----------------........-----------------------.-...... 93 ------...-----------------........-----------------------.-...... 94 ------...-----------------........-----------------------.-...... 95 ------...-----------------........-----------------------.-...... 96 ------...-----------------........-----------------------.-...... 97 ------...-----------------........-----------------------.-...... 98 ------...-----------------........-----------------------.-...... 99 ------...-----------------........-----------------------.-...... 100 ------...-----------------........-----------------------.-...... 101 PDLRPV...FDVLGRVAVPQPAVLFDsat20dgfGSFSRAELAAASAAVSYVEKTQL.Q...... 102 EYLQQR...NGVRRRPPWLFDADSGRrkl16gfgIENNPQATAAAGALLGYIEETQK.Q...... 103 ------...-----------------........-----------------------.-...... 104 ------...-----------------........-----------------------.-...... 105 LKRQIN...MVTETITVRETLSSEIYsvn.....QTEHKLMYQATQLLLDYIHHTQK.R...... 106 TVAQLR...ERCGATISIEDGETDEHvtiie...HLNNEDITKTFLRLYTYLKRTQK.R...... 107 TVAQLR...ERCGATISIEDGETDEHvtiie...HLNNEDITKTFLRLYTYLKRTQK.R...... 108 EEQILS...RQMNLVLSYEKESFEDLhlld....LRLATVEQTASSKLLQYVHRTQM.R...... 109 EKLEKV...LKLHITELEEEFFEEGKeel15kafGFQDEDLSLSLGAVYRYAKATQK.S...... 110 EELEKV...LKVYVSELEEEFFEEGSeei15qafGFEEDTYSLPLGAVYKYAKTTQK.G...... 111 LKERFP...GVYTETISEWYFSDLEEvek12ihhFELSPLALKALAALIKYVKYTMIaE...... 112 LKERFP...GVYTETISEWYFSDLEEvek12ihhFELSPLALKALAALIKYVKYTMI.Ge..... 113 ISDSIL...KQFNCRITYQVDSFFAInkc19kgiGEISNSQICAIGSILEYLSLTQK.Q...... 114 MQKVIN...VIDRCGCVVTLLKNSEFsek22slpQKYSKLSMGACNALIGYLQLLSEqD...... 115 MQKVIN...VIDRCGCVVTLLKNSEFsek22slpQKYSKLSMGACNALIGYLQLLSEqD...... 116 MGKLRQ...IVKRGGILITDRKRAEFstk27alpEMEKQVAMSALAAVMKYLELLSD.Es..... 117 MGKLRQ...VIQRGGILITERKRIDFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 118 MGKLRQ...VIQRGGILITERKRADFstk27alpEMENQVAVSSLSAVIKFLELLSD.Ds..... 119 MGKLRQ...VIQRGGILITERKRADFstk27alpEMENQVAVSSLSAVIKFLELLSD.Ds..... 120 MGKLRQ...IIQRGGILITERKKADFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 121 MGKLRQ...IIQRGGILITERKKADFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 122 MGKLRQ...IIQRGGILITERKKADFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 123 MGKLRQ...IIQRGGILITERKKADFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 124 MGKLRQ...IIQRGGILITERKKADFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 125 MGKLRQ...IIQRGGILITERKKADFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 126 MGKLRQ...IIQRGGILITERKKADFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 127 LAKLRQ...IIDNCGVAIAERSAGEFgtk23llpQTDLKLAMGSASALIKYLGILHDpS...... 128 ------...-----------------........-----------------------.-...... 129 TNGNSA...VSINTAEINRLRNIIEGcga36lvpELGLQLAMASCNALLRYLGPALL.Npdmedd 130 TNGNSA...VSINTAEINRLRNIIEGcga36lvpELGLQLAMASCNALLRYLGPALL.Npdmedd 131 LNPLQD...VISNCNVLLTEKKKADFksr23rdlLSQFDYALGPLGALLSYAELLAD.Dt..... 132 ------...-----------------........-----------------------.-...... 133 CKSLYD...SLERCAVMITERKKHEFkgr23rdlVSGFDLATPALGALLSFSELLSNeD...... 134 CKSLYD...SLERCAVMITERKKHEFkgr23rdlVSGFDLATPALGALLSFSELLSNeD...... 135 SAVKTL...LDRNGVMITMPKKSGDNdll24glkELQLQLASNALKTAIKYLDLVNDaG...... 136 SAVKTL...LDRNGVMITMPKKSGDNdll24glkELQLQLASNALKTAIKYLDLVNDaG...... 137 SAVKTL...LDRNGVMITMPKKSGDNdll24glkELQLQLASNALKTAIKYLDLVNDaG...... 138 MSRAIE...RLKAMAGSHDSSMTEEDkyi9kmrfDIEAVNMIRSFGALLLFLDETRM.G...... 139 MSRAIE...RLKAMAGSHDSSMTEEDkyi9kmrfDIEAVNMIRSFGALLLFLDETRM.G...... 140 MSRAIE...RLKAMAGSHDSSMTEEDkyi9kmrfDIEAVNMIRSFGALLLFLDETRM.G...... 141 ------...-----------------........-----------------------.-...... 142 MTRFLG...KLASEEHREPKGPEIILlps40siiPFDCVLTVRALGGLLKFLSRRRI.G...... 143 MTRFLG...KLASEEHREPKGPEIILlps40siiPFDCVLTVRALGGLLKFLSRRRI.G...... 144 MTRFLG...KLASQEHREPKRPEIIFlps57tpiPLLIPSQVRALGGLLKFLGRRRI.G...... 145 MTRFLG...KLASQEHREPKRPEIIFlps40siiPFDCLLTVRALGGLLKFLGRRRI.G...... 146 ------...-----------------........-----------------------.-...... 147 MTRFLG...KLASQEHREPKRPEIIFlps40siiPFDCLLTVRALGGLLKFLGRRRI.G...... 148 LQLRGHdnqTILNDILSNSKFTTTVT........LGTVGCILANHEQLGEYNDSTAS.S...... 149 LQLRGHdnqTILNDILSNSKFTTTVT........LGTVGCILANHEQLGEYNDSTAS.S...... 150 SNILIN...KIYNLLIGWNLFPSEPNaki60twtENVNQANLISLLGVLQFIKDRNP.N...... 151 SNILIN...KIYNLLIGWNLFPSEPNaki60twtENVNQANLISLLGVLQFIKDRNP.N...... 240 250 260 | | | 1 E........YSISEkys.IFNYGT........HGNMLIDSCAVEALE...LFQ........LNYN 2 L........LSNIDk...IDINND........SSYMFLDDVTQVNLE...LVK........NNND 3 F........SINFQi...PQRQLA........TAIMQIDSRTSTALE...LHS........TVRD 4 F........SINFQi...PQRQLA........TAIMQIDSRTSTALE...LHS........TVRD 5 S........HPNIQp...PIRVSL........NEYMIIGESAMKGLE...IRS........SLYQ 6 -........-----....------........---------------...---........---- 7 S........HPNIQp...PIRVSL........NEYMIIGESAMKGLE...IRS........SLYQ 8 -........-----....------........----------RKNLE...LFR........NAL- 9 R........LLVVS....EDEVEE........AEKLGLCMVSTEPIEgydIVL........STIG 10 R........VLIVS....EDEVEE........AEKLNLCIVSTEPIEgydIVL........STIG 11 -........-----....------........---------------...---........---- 12 -........-----....------........---MAFDSRALSALD...FPRit......---- 13 -........-----....------........---------------...---........---- 14 -........-----....------........---------------...---........---- 15 -........-----....------........---------------...---........---- 16 -........-----....------........---------------...---........---- 17 -........-----....------........---------------...---........---- 18 -........-----....------........---------------...---........---- 19 -........-----....------........---------------...---........---- 20 -........-----....------........---------------...---........---- 21 -........-----....------........---------------...---........---- 22 -........-----....------........---------------...---........---- 23 -........-----....------........---------------...---........---- 24 A........FRKLR....IQFEGT........ENTMLIDSKTVRGLE...LVE........NKLD 25 A........FRKLR....IQFEGT........ENTMLIDSKTVRGLE...LVE........NKLD 26 V........TNKIR....LKYCMC........ENTMLIDTCTVRDLE...LVD........SLSE 27 V........YAPKSlk..ICFQGS........EQTAMIDSSSAQNLE...LLI........NNQD 28 V........YAPKSlk..ICFQGS........EQTAMIDSSSAQNLE...LLI........NNQD 29 F........FRVKSlr..IKEMGV........NDTCMIDFVSWESLE...IVD........ADDA 30 Q........VMLIPsi..YSPFAS........KIHMLLDPNSLQSLD...IFT........HDGG 31 Q........VMLIPsi..YSPFAS........KIHMLLDPNSLQSLD...IFT........HDGG 32 R........ILYQGas..FRSLSS........NTEMTLSANTLQQLE...VVK........NNSD 33 R........ILYQGas..FRSLSS........NTEMTLSANTLQQLE...VVK........NNSD 34 R........ILYQGas..FRSLSS........NTEMTLSANTLQQLE...VVK........NNSD 35 K........MLSKPesf.KQLSSG........MEFMRINGTTLRNLE...ILQ........NQTD 36 -........-----....------........---------------...---........---- 37 K........MLSKPesf.KQLSSG........MEFMRINGTTLRNLE...MVQ........NQTD 38 K........MLSKPesf.KQLSSG........MEFMRINGTTLRNLE...MVQ........NQTD 39 K........MLSKPesf.KQLSSG........MEFMRINGTTLRNLE...ILQ........NQTD 40 K........MLSKPenf.KQLSSK........MEFMTINGTTLRNLE...ILQ........NQTD 41 K........MLSKPenf.KQLSSK........MEFMTINGTTLRNLE...ILQ........NQTD 42 D........LFVASnf..YQPFDS........ISSMVLSKQALEGLE...LFV........NQTD 43 D........LFVASnf..YQPFDS........ISSMVLSKQALEGLE...LFV........NQTD 44 M........LSMRN....VTIYNSnsm15dwnGKNLILDGTALENLN...IVP........NGRD 45 V........LPMAR....YQLYVPpdq16tlrRSHMVLDATTLSNLR...II-........--GE 46 L........LSMAN....FEEYIPlds18tkaYQRMVLDAVTLNNLE...IFL........NGTN 47 L........LSMAN....FEEYIPlds18tkaYQRMVLDAVTLNNLE...IFL........NGTN 48 L........LSMAN....FEEYIPlds18tkaYQRMVLDAVTLNNLE...IFL........NGTN 49 L........LSMAN....FEEYIPlds18tkaYQRMVLDAVTLNNLE...IFL........NGTN 50 L........LSMAN....FEEYIPlds18tkaYQRMVLDAVTLNNLE...IFL........NGTN 51 L........LSMAN....FEEYFPlds18tkaSQRMVLDAVTLNNLE...IFL........NGTN 52 L........LSMAN....FEEYFPlds18tkaSQRMVLDAVTLNNLE...IFL........NGTN 53 A........LKNGEv...LPYHVY........KTCLRMDGQTLVNLE...IFI........NNFN 54 A........LKNGEv...LPYHVY........KTCLRMDGQTLVNLE...IFI........NNFN 55 -........-----....------........---------------...---........---- 56 V........LKHGDi...FPYQVY........RGCLRIDGQTMVNLE...IFN........NSCD 57 -........-----....------........---------------...---........---- 58 -........-----....------........---------------...---........---- 59 -........-----....------........------DTAALENLE...LLE........NTRT 60 -rfakfes.LPYCD....FSNVNE........KQHMVLDAAALENLE...IFE........NSRN 61 -rfakfes.LPYCD....FSNVNE........KQHMVLDAAALENLE...IFE........NSRN 62 M........CSMGN....FDEYDAsqq.....STSLLMNGQTLKNLE...IFS........NSFD 63 L........ISMKN....IKEYDFvks.....QHSMVLDGITLQNLE...IFS........NSFD 64 L........ISMKN....IKEYDFvks.....QHSMVLDGITLQNLE...IFS........NSFD 65 P........LSHVSa...ITRYHI........HDFVEIDDATRKNLE...ILQ........NLHD 66 A........LSLQP....FRFYDP........GAFMRLPEATLRALE...VFE........PLRG 67 A........LSLQP....FRFYDP........GAFMRLPEATLRALE...VFE........PLRG 68 A........LSVRP....FRLYDP........GAFVRLPEASLKALE...VFE........PLRG 69 A........LSVRP....FRLYDP........GAFVRLPEASLKALE...VFE........PLRG 70 A........LSVRP....FRLYDP........GAFVRLPEASLKALE...VFE........PLRG 71 A........LSVRP....FRLYDP........GAIVRLPEASLKALE...VFE........PLRG 72 V........VPIQP....LKTYGL........TDFLVLDHQTRRNLE...INQ........TVRD 73 V........VPIQP....LKTYGL........TDFLVLDHQTRRNLE...INQ........TVRD 74 P........TKHIAi...PQTRGK........QQKLLIDTASQVNLE...LLA........PLND 75 P........TKHIAi...PQTRGK........QQKLLIDTASQVNLE...LLA........PLND 76 P........ISHLSi...PKIYGQ........QKHLLIDKASQTNLE...LLS........PIHG 77 -........-----....------........---------------...---........---- 78 -........-----....------........---------------...---........---- 79 P........ISHLSi...PKIYGQ........HKHLLIDKASQTNLE...LLS........AIHG 80 M........PQHLDg...LSLETD........SQYIGMDAATRRNLE...ITQ........TLSG 81 M........PQHLDg...LSLETD........SQYIGMDAATRRNLE...ITQ........TLSG 82 A........LPHIQs...ISLIQN........QDCIQLDAATRRNLE...LTQ........NLAG 83 T........LPHIRs...ITMERE........QDSIIMDAATRRNLE...ITQ........NLAG 84 T........LPHIRs...ITMERE........QDSIIMDAATRRNLE...ITQ........NLAG 85 T........LPHIRs...ITMERE........QDSIIMDAATRRNLE...ITQ........NLAG 86 S........LPHIRs...ITMERQ........QDSIIMDAATRRNLE...ITQ........NLAG 87 S........LPHIRs...ITMERQ........QDSIIMDAATRRNLE...ITQ........NLAG 88 A........LPHLRg...LRHERL........DDTVILAGASRRNLE...LDV........NLSG 89 A........LPHLRs...LRHDRL........DDTVILDGASRRNLE...LDI........NLSG 90 A........LPHLRs...LRHDRL........DDTVILDGASRRNLE...LDI........NLSG 91 -........-----....------........---------------...---........---- 92 -........-----....------........---------------...---........---- 93 -........-----....------........---------------...---........---- 94 -........-----....------........---------------...---........---- 95 -........-----....------........---------------...---........---- 96 -........-----....------........---------------...---........---- 97 -........-----....------........---------------...---........---- 98 -........-----....------........---------------...---........---- 99 -........-----....------........---------------...---........---- 100 -........-----....------........---------------...---........---- 101 E........RPALGi...PERESA........ASTLFIDPATRANLE...LAK........TLSG 102 R........LPHLTs...ITMETV........GEAITMNAATRRHLE...LDT........RVDG 103 -........-----....------........---------------...---........---- 104 -........-----....------........---------------...---........---- 105 D........LSHIEd...VVQYAA........IDYMKMDFYAKRNLE...LTE........SIRL 106 S........LDHLQp...VQVYEL........EEAMKIDLYSKRNLE...LTE........TIRS 107 S........LDHLQp...VQVYEL........EEAMKIDLYSKRNLE...LTE........TIRS 108 E........LNHLKp...VIRYEI........KDFLQMDYATKASLD...LVE........NARS 109 F........TPLIPk...PKPYVD........EGYVKLDLKAVKGLE...ITE........SIEG 110 Y........TPLIPr...PKPYRD........EGFVRLDIKAIKGLE...ILE........SLEG 111 D........LNLKP....PLLISQ........RDYMILDSATVENLS...LIP........GDRG 112 D........LNLKP....PLLISQ........RDYMILDSATVENLS...WIP........GDRG 113 N........IPHLPi...PKIINF........HNYMTIDFSTRRNLE...IVT........NLQG 114 Q........VGKYE....LVEHKL........KEFMKLDASAIKALN...LFPqgp20tsa---- 115 Q........VGKYE....LVEHKL........KEFMKLDASAIKALN...LFPqgp20tsa---- 116 N........FGQFV....MTNFDL........SQYMKLDNAAVGALN...LFP........GSAE 117 N........FGQFE....LATFDF........SQYMKLDMAAVRALN...LFQ........GSVE 118 N........FGQFE....LATFDF........SQYMKLDMAAVRALN...LFQ........GSVE 119 N........FGQFE....LATFDF........SQYMKLDMAAVRALN...LFQ........GSVE 120 N........FGQFE....LTTFDF........SQYMKLDIAAVRALN...LFQ........GSVE 121 N........FGQFE....LTTFDF........SQYMKLDIAAVRALN...LFQ........GSVE 122 N........FGQFE....LTTFDF........SQYMKLDIAAVRALN...LFQ........GSVE 123 N........FGQFE....LTTFDF........SQYMKLDIAAVRALN...LFQ........GSVE 124 N........FGQFE....LTTFDF........SQYMKLDIAAVRALN...LFQ........GSVE 125 N........FGQFE....LTTFDF........SQYMKLDIAAVRALN...LFQ........GSVE 126 N........FGQFE....LTTFDF........SQYMKLDIAAVRALN...LFQ........GSVE 127 N........FGQYQ....LYQHDL........AQFMKLDAAALKALN...LMP........GARD 128 -........-----....------........---------------...---........---- 129 -rent....SRKLH....LYHHNL........EQYMRLDIAAVRSLN...LLP........PPNG 130 -rent....SRKLH....LYHHNL........EQYMRLDIAAVRSLN...LLP........PPNG 131 N........YGNYT....IEKYNL........NCYMRLDSAAVRALN...IAE........GKTD 132 -........-----....------........---------------...---........---- 133 N........YGNFT....IRRYDI........GGFMRLDSAAMRALN...VME........SKTD 134 N........YGNFT....IRRYDI........GGFMRLDSAAMRALN...VME........SKTD 135 N........LGHYE....IKQLDL........NRFVHLDSAAVAALN...IMP........KPGT 136 N........LGHYE....IKQLDL........NRFVHLDSAAVAALN...IMP........KPGT 137 N........LGHYE....IKQLDL........NRFVHLDSAAVAALN...IMP........KPGT 138 VtddplsvtSPIKS....IKTFTL........GNLVEIDFNTIQALD...ILP........KETE 139 VtddplsvtSPIKS....IKTFTL........GNLVEIDFNTIQALD...ILP........KETE 140 VtddplsvtSPIKS....IKTFTL........GNLVEIDFNTIQALD...ILP........KETE 141 -........-----....------........---------------...---........---- 142 VeledydvgVPILG....FKKFVL........THLVSIDQDTYSVLQ...IFKses11kva---- 143 VeledydvgVPILG....FKKFVL........THLVSIDQDTYSVLQ...IFKses11kva---- 144 VeledynvsVPILG....FKKFML........THLVNIDQDTYSVLQ...IFKses11kva---- 145 VeledynvsVPILG....FKKFML........THLVNIDQDTYSVLQ...IFKses11kva---- 146 -........-----....------........---------------...---........---- 147 VeledynvsVPILG....FKKFML........THLVNIDQDTYSVLQ...IFKses11kva---- 148 Nmvt12afeDVIHG....IRYIDI........RDRMVLDENTISALH...IFP........TAHK 149 Nmvt12afeDVIHG....IRYIDI........RDRMVLDENTISALH...IFP........TAHK 150 L........IKNLQlpecYNSVVS........PLNLILCNRAEYQLD...LLS........KRGK 151 L........IKNLQlpecYNSVVS........PLNLILCNRAEYQLD...LLS........KRGK 270 280 290 300 310 | | | | | 1 Yleksnn..LTLYNVLNKCKT.LPGEKLLRDWLSRPLCQIDHINERLDIV.EAL........F.. 2 Fssq.....YSLYSVLNDCKT.AMGKRLLREFILNPILNISEINTRLDHV.EFF........C.. 3 Nnkk.....GSLLSSIRRTVT.PSGTRLLSQWLSGPSLDLKEIKKRQKIV.AFF........K.. 4 Nnkk.....GSLLSSIRRTVT.PSGTRLLSQWLSGPSLDLKEIKKRQKIV.AFF........K.. 5 Nryt.....GSLLHAINKTVT.KSGSRLLTRRLCAPSTNIVEINNRLDLV.EKF........K.. 6 -........------------.----------------------------.---........-.. 7 Nryt.....GSLLHAINKTVT.KSGSRLLTRRLCAPSTNIVEINNRLDLV.EKF........K.. 8 -........------------.-------------------EIKRILGME.TCL........H.. 9 Ygidv....------------.-----ELKPYEIAPELYIKPLWESRDVL.EAL........A.. 10 Ygiev....------------.-----ELKPYEIAPELYVKPLWENRGVL.EAL........A.. 11 -........------------.----------------------------.---........-.. 12 -........---AALADRAAT.SLGRE--RALALRPSDDAYRIAQELDEV.E--........-.. 13 -........------------.----------------------------.---........-.. 14 -........------------.-------------------ELLAQTQAV.ESI........E.. 15 -........-----VIGHAAS.SLGKEMLLE--LKPSASIDEIKKQLDEV.DEA........S.. 16 -........------------.----------------------------.---........-.. 17 -........----------LS.DLGRKHLDT--LKPTVNP---WDELELV.EEL........L.. 18 -........------------.------------KPYTNKEKVKEEIELS.KAF........F.. 19 -........------------.---------------------LKTKESL.EKI........F.. 20 -........------------.----------------ERDTIALENDLK.QTF........T.. 21 -........------------.----------------ERGSIALENDLK.QAF........T.. 22 -........------------.------------------KEIFLQGDSN.LHF........K.. 23 -........------------.------------------KEIFLQGDSN.LHF........K.. 24 Kng......ISLWKFLDTTST.KMGQRSLRNSILQPLTDRGSIEMRLEAL.EEL........K.. 25 Kng......ISLWKFLDTTST.KMGQRSLRNSILQPLTDRGSIEMRLEAL.EEL........K.. 26 Tg.......TTLYSFLNCCLT.KMGMRILRTSILQPSTHENSIILRSESL.QEL........I.. 27 Yrnn.....HTLFGVLNYTKT.PGGSRRLRSNILEPLVDIETINMRLDCV.QEL........L.. 28 Yrnn.....HTLFGVLNYTKT.PGGSRRLRSNILEPLVDIETINMRLDCV.QEL........L.. 29 Skar10kqkRTLMSVLNHTVT.TNGYRLLRSSVLQPSTDVYLIQSRQEAI.EEL........I.. 30 K........GSLFWLLDHTRT.SFGLRMLREWILKPLVDVHQIEERLDAI.ECI........Tse 31 K........GSLFWLLDHTRT.SFGLRMLREWILKPLVDVHQIEERLDAI.ECI........Tse 32 Gses.....GSLFHNMNHTLT.VYGSRLLRHWVTHPLCDRNLISARLDAV.SEIsac27ivsP.. 33 Gses.....GSLFHNMNHTLT.VYGSRLLRHWVTHPLCDRNLISARLDAV.SEIsac27ivsP.. 34 Gses.....GSLFHNMNHTLT.VYGSRLLRHWVTHPLCDRNLISARLDAV.SEIsac27ivsP.. 35 Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQPLLKLREINARLDAVsDVL........H.. 36 -........------------.----------------------------.---........-.. 37 Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQPLLKLREINARLDAVsDVL........H.. 38 Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQPLLKLREINARLDAVsDVL........H.. 39 Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQPLLKLREINARLDAVsDVL........H.. 40 Mktk.....GSLLWVLDHTKT.SFGRRKLKKWVTQPLLKLREINARLDAVsEVL........H.. 41 Mktk.....GSLLWVLDHTKT.SFGRRKLKKWVTQPLLKLREINARLDAVsEVL........H.. 42 Htpv.....GSLFWVLDRTYT.RFGQRMLQRWLQKPLVDKENIIERLDAV.EEL........Af. 43 Htpv.....GSLFWVLDRTYT.RFGQRMLQRWLQKPLVDKENIIERLDAV.EEL........Af. 44 Shl......TSLYYVINKCST.PFGRRLLRSWLLQPTCDPKKLEQRQKAI.KWL........Vsp 45 E........HSLLSTLDHCCT.KFGKRLLHHWLCAPSCDVSVIKERQDAI.GEL........I.. 46 Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDRLDAI.EDL........M.. 47 Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDRLDAI.EDL........M.. 48 Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDRLDAI.EDL........M.. 49 Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDRLDAI.EDL........M.. 50 Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDRLDAI.EDL........M.. 51 Gste.....GTLLERLDTCHT.PFGKRLLKQWLCAPLCSPSAISDRLDAV.EDL........M.. 52 Gste.....GNLLERLDTCHT.PFGKRLLKQWLCAPLCSPSAISDRLDAV.EDL........M.. 53 Ggss.....GTLYKHLNHCVT.ASGKRMLRRWICHPLKDIDAINKRLDVV.EGF........I.. 54 Ggss.....GTLYKHLNHCVT.ASGKRMLRRWICHPLKDIDAINKRLDVV.EGF........I.. 55 -........------------.----------------------------.---........-.. 56 Gvlq.....GPLNKYLENCVS.PTGKRLLRNWICHPLKDVESINKRLDVV.EEF........T.. 57 -........------------.----------------------------.---........-.. 58 -........------------.----------------------------.---........-.. 59 Ggls.....GTLYAQLNHCVT.GFGKRLLKRWIAKPLYDCREILRRQSAV.ATF........K.. 60 Ggys.....GTLYAQLNQCIT.ASGKRLLKTWLARPLYNTELIKERQDAV.AIL........Rg. 61 Ggys.....GTLYAQLNQCIT.ASGKRLLKTWLARPLYNTELIKERQDAV.AIL........Rg. 62 Ggse.....GTLFHLLCRCVT.PFGKRLFHTWLCHPLRSGTAINARLDVV.ELI........A.. 63 Gsdk.....GTLFKLFNRAIT.PMGKRMMKKWLMHPLLRKNDIESRLDSV.DSL........L.. 64 Gsdk.....GTLFKLFNRAIT.PMGKRMMKKWLMHPLLRKNDIESRLDSV.DSL........L.. 65 Stha.....HSLFETLNYTHT.AMGTRLLRYWLHHPLRSQEEIQKRLSAV.VFF........H.. 66 Q........DTLFSVLDETRT.APGRRLLQSWLRHPLLDRGPLEARLDRV.EGF........V.. 67 Q........DTLFSVLDETRT.APGRRLLQSWLRHPLLDRGPLEARLDRV.EGF........V.. 68 Q........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV.ERF........V.. 69 Q........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV.ERF........V.. 70 Q........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV.ERF........V.. 71 Q........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV.ERF........V.. 72 Gsfh.....GSLLWALDRTST.TMGSRALRRWLLQPLLDLKGIQARQDTI.QEL........Y.. 73 Gsfh.....GSLLWALDRTST.TMGSRALRRWLLQPLLDLKGIQARQDTI.QEL........Y.. 74 Pqgk.....NSLLRIMDHTST.PMGGRLLRQILISPFYNPKEILVRQDAV.EFF........L.. 75 Pqgk.....NSLLRIMDHTST.PMGGRLLRQILISPFYNPKEILVRQDAV.EFF........L.. 76 Ehgk.....GSLLQVMERTST.PMGGRLLRNTLINPFYDLKEITLRQDSV.EFF........L.. 77 -........------------.----------------------------.---........-.. 78 -........------------.----------------------------.---........-.. 79 Ehgk.....GSLLQVMERTST.PMGGRLLRNTLVNPFYDLKEITLRQDSV.EFF........L.. 80 Kks......PTLMSTLDLCAT.HMGSRLLALWLHHPLRNRAHIRARQEAV.AAL........E.. 81 Kks......PTLMSTLDLCAT.HMGSRLLALWLHHPLRNRAHIRARQEAV.AAL........E.. 82 Gte......NTLASVLDKCVT.PMGSRLLKRWIHQPVRDVEKLKQRQQSI.AEI........L.. 83 Gae......NTLASVLDCTVT.PMGSRMLKRWLHMPVRHTRVLLERQQTI.GAL........Q.. 84 Gae......NTLASVLDCTVT.PMGSRMLKRWLHMPVRDTRVLLERQQTI.GAL........Q.. 85 Gae......NTLASVLDCTVT.PMGSRMLKRWLHMPVRDTRVLLERQQTI.GAL........Q.. 86 Gve......NTLAAVLDCTVT.PMGSRMLKRWLHMPVRNTDILRERQQTI.GAL........Q.. 87 Gve......NTLAAVLDCTVT.PMGSRMLKRWLHMPVRNTDILRERQQTI.GAL........Q.. 88 Grd......NTLQSVIDRCQT.AMGSRLLGRWLNRPLRDRAVLEARQDTV.ACL........L.. 89 Gre......NTLQSVVDRCQT.AMASRLMSRWLNRPLRDRAVLEARQESI.ACL........L.. 90 Gre......NTLQSVVDRCQT.AMASRLMSRWLNRPLRDRAVLEARQESI.ACL........L.. 91 -........------------.----------------------------.---........-.. 92 -........------------.----------------------------.---........-.. 93 -........------------.----------------------------.---........-.. 94 -........------------.----------------------------.---........-.. 95 -........------------.----------------------------.---........-.. 96 -........------------.----------------------------.---........-.. 97 -........------------.----------------------------.---........-.. 98 -........------------.----------------------------.---........-.. 99 -........------------.----------------------------.---........-.. 100 -........------------.----------------------------.---........-.. 101 Srd......GSLLKSLDRTMT.SGGARLLAERLMSPLTDPERINQRLDSI.EVL........A.. 102 Esr......HTLLGVLDSTVT.PMGGRLLRRWLHRPLRLREVVRQRHAAV.GSM........I.. 103 -........------------.----------------------------.---........-.. 104 -........------------.----------------------------.---........-.. 105 Kskk.....GTLLWLMDETKT.PMGARRLKQWIDRPLISKEQIEARLDIV.DEF........S.. 106 Knkk.....GSLLWLLDETKT.AMGGRLLKQWIDRPLIRVNQIEERQEMV.ETL........M.. 107 Knkk.....GSLLWLLDETKT.AMGGRLLKQWIDRPLIRVNQIEERQEMV.ETL........M.. 108 Gkkq.....GSLFWLLDETKT.AMGMRLLRSWIHRPLIDKERIVQRQEVV.QVF........L.. 109 Rkd......LSLFKVVDRTLT.GMGRRRLRFRLLNPFRSIERIRKVQEAV.EEL........I.. 110 Rkd......ISLFKVIDRTLT.GMGRRRLKFRLLSPFRSREKIERIQEGV.QEL........K.. 111 Kn.......--LFDVLNNTET.PMGARLLKKWILHPLVDRKQIEERLKAV.ERL........V.. 112 Kn.......--LFDVLNNTET.PMGARLGKKWILHPLVDRKQIEERLKAV.ERL........V.. 113 Nly......GSVLNTLNHTVT.TQGGRLLYHFLSSPLTNIAKINHRLNIT.EFF........Y.. 114 -gnsgkv..TSLFQLLNHCKT.NAGVRLLNEWLKQPLTNIDEINKRHDLV.DYL........I.. 115 -gnsgkv..TSLFQLLNHCKT.NAGVRLLNEWLKQPLTNIDEINKRHDLV.DYL........I.. 116 Dtsgt....QSLAGLLNKCKT.PQGQRLVNQWIKQPLMDKNRVEERLNLV.EAF........V.. 117 Dttgs....QSLAAFLNKCKT.AQGQRLVSQWIKQPLMDKNRIEERLNLV.EAF........V.. 118 Dttgs....QSLAALLNKCKT.AQGQRLVNQWIKQPLMDRNRIEERLNLV.EAF........V.. 119 Dttgs....QSLAALLNKCKT.AQGQRLVNQWIKQPLMDRNRIEERLNLV.EAF........V.. 120 Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEERLNLV.EAF........V.. 121 Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEERLNLV.EAF........V.. 122 Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEERLNLV.EAF........V.. 123 Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEERLNLV.EAF........V.. 124 Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEERLNLV.EAF........V.. 125 Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEERLNLV.EAF........V.. 126 Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEERLNLV.EAF........V.. 127 Gakn.....MSLYGLLNHCKT.PVGSRLLSQWLKQPLMNAEEIEKRQQLV.EAF........A.. 128 -........------------.----------------------------.---........-.. 129 Nahkt....MSLYGLLNHCRT.AMGARNLRRWIVQPLLDAKSIERRHDLV.SAL........V.. 130 Nahkt....MSLYGLLNHCRT.AMGARNLRRWIVQPLLDAKSIERRHDLV.SAL........V.. 131 Vnkn.....FSLFGLMNRTCTvGMGKRLLNRWLKQPLLDVNEINNRLDMV.QAF........V.. 132 -........------------.----------------------------.---........-.. 133 Ankn.....FSLFGLMNRTCTaGMGKRLLHMWLKQPLVDLNEIKTRLDIV.QCF........V.. 134 Ankn.....FSLFGLMNRTCTaGMGKRLLHMWLKQPLVDLNEIKTRLDIV.QCF........V.. 135 HpsmpsyrwQSVLGVLDHCRT.PQGHRLMGQWVKQPLRSRNILNDRHNIV.QCL........L.. 136 HpsmpsyrwQSVLGVLDHCRT.PQGHRLMGQWVKQPLRSRNILNDRHNIV.QCL........L.. 137 HpsmpsyrwQSVLGVLDHCRT.PQGHRLMGQWVKQPLRSRNILNDRHNIV.QCL........L.. 138 Nkktfgqg.RSLYQLMDKCRS.TVGKKCLRKWFRNPTTDRDDLVSRQKCV.HYF........K.. 139 Nkktfgqg.RSLYQLMDKCRS.TVGKKCLRKWFRNPTTDRDDLVSRQKCV.HYF........K.. 140 Nkktfgqg.RSLYQLMDKCRS.TVGKKCLRKWFRNPTTDRDDLVSRQKCV.HYFkqviifk.V.. 141 -........------------.----------------------------.---........-.. 142 -sglkeg..LSLFGILNRCRC.KWGQKLLRLWFTRPTRELRELNSRLDVI.QFF........Lmp 143 -sglkeg..LSLFGILNRCRC.KWGQKLLRLWFTRPTRELRELNSRLDVI.QFF........Lmp 144 -sglkeg..LSLFGILNRCHC.KWGEKLLRLWFTRPTHDLGELSSRLDVI.QFF........Llp 145 -sglkeg..LSLFGILNRCHC.KWGEKLLRLWFTRPTHDLGELSSRLDVI.QFF........Llp 146 -........------------.----------------------------.---........-.. 147 -sglkeg..LSLFGILNRCHC.KWGEKLLRLWFTRPTHDLGELSSRLDVI.QFF........Llp 148 Lghd10ngfFSVFELFNQVSS.DYARRILKSWLINPLTNKKRIETRYSII.RTL........Ldk 149 Lghd10ngfFSVFELFNQVSS.DYARRILKSWLINPLTNKKRIETRYSII.RTL........Ldk 150 L........GGLLNLIDYCST.AMGKRLLKFRLLNPITDYSELNLRYKDI.SIF........K.. 151 L........GGLLNLIDYCST.AMGKALLKFRLLNPITDYSELNLRYKDI.SIF........K.. 320 330 340 350 360 | | | | | 1 .ENQ..TIRQKLRd..SILARMPDCSQLARRLMrkc16aatLLET..VEMQLIQLSE.AEQFAPS 2 .KNI..SLTVTLR...ETFINIWDIERIISRIQ........MKRY..IKKDFLFIEK.ALSVFFT 3 .DNR..DITENLR...TMLKKVNDLSRILQKFS........FGRG..EALELIQMAR.SLEVSRE 4 .DNR..DITETLR...TMLKKVNDLSRILQKFS........FGRG..EALELIQMAR.SLEVSRE 5 .LLP..ELCSKVI...NLLKKSNDTHRILQHLL........MGRG..NSYDLLKMAD.NFSITKE 6 .---..-------...-----------------........----..----------.------- 7 .LLP..ELCSKVI...NLLKKSNDTHRILQHLL........MGRG..NSYDLLKMAD.NFSITKE 8 .EVV..EIMDELQ...AAGGEEVDIDEVVNSVKa.......WADM..KLRDLIKDID.------- 9 .RIFpgGAAAKIL...RELEGIEDVMRRNERLE........----..NIEEIIRRYE.S-ELNKR 10 .NVF..PN-GVSR...KILERLNELEDVFKRLK........--TL..ENLEERIREL.EIELNRK 11 .---..-----RG...LGLSEIQDLSDIVERAV........SGQLl.TVRELCTVRS.TLTAATS 12 .---..DALFGVS...LSLGGIHDIRDIHARAG........EGRVl.SGQDLLNAAY.SLDGAMT 13 .---..-------...-----------------........----..----------.----VAS 14 .NSP..ES----N...WHFKGIADITEPLARVE........RGGLv.TGLELLAIAG.TLAGVRR 15 .DII..RLRG--Q...APFGGLVDIRGALRRAE........IGSVl.SPSEFTEISG.LLYAVKQ 16 .---..-------...-----------------........--VL..NVSELNLIKR.LIQVQNQ 17 .NYF..NRWGE--...PPIKGLNDISQEVEKVK........SGSPl.EPWELLRVSV.FLEGCDI 18 .DIA..ENVR---...--LFEFEDIRELLKKAK........LQGAilGVEDILKILN.VINLTKE 19 .SFV..SLIRMLF...ESCKGYPNSFINSLKYPisl10nsrVSIE..NLRDIIVFLD.EVLRINL 20 .YLN..EVDAIGL...PTPKSVKESDLIIIKLTk.......LGTL..HLDEIFEIVK.RLHYIVV 21 .YLN..EVDAIGL...PAPKSVKESDLIVVKLTk.......LGTL..HLDEIYEIVK.RLRYIVV 22 .RIH..ELCEVEF...PTMPELSNLDKAL--VH........LSKQ..GILHLDEIFE.FVKIFRY 23 .RIH..ELCEVEF...PTIPELSNLDKAL--VH........LSKQ..GILHLDEIFE.FVKIFRY 24 .AND..DLLQKLR...LEMKSLPDLDKLFSRLLcinhsai.KPDQ..RINYVLLLKE.TLQSVKS 25 .AND..DLLQKLR...LEMKSLPDLDKLFSRLLcinhsai.KPDQ..RINYVLLLKE.TLQSVKS 26 .NDE..DALISIR...SSLKHTCDLEKVFSTFLeprgll..SQEQ..EINNIILLKT.VLQNTFV 27 .QDE..ELFFGLQ...SVISRFLDTEQLLSVLVqip9dtvnAAES..KITNLIYLKH.TLELVDP 28 .QDE..ELFFGLQ...SVISRFLDTEQLLSVLVqip9dtvnAAES..KITNLIYLKH.TLELVDP 29 .GKP..QLKDKLR...RTLSRAHELDRVIAMCIqts9wtvrESEA..KINQIIKLMH.TLKVIQG 30 iNNS..IFFESLN...QMLNHTPDLLRTLNRIM........YGTT..SRKEVYFYLK.QITSFVD 31 iNNS..IFFESLN...QMLNHTPDLLRTLNRIM........YGTT..SRKEVYFYLK.QITSFVD 32 .EFY..LVLSSVL...TAMSRSSDIQRGITRIF........HRTA..KATEVKIWPV.LCPLMYV 33 .EFY..LVLSSVL...TAMSRSSDIQRGITRIF........HRTA..KATEVKIWPV.LCPLMYV 34 .EFY..LVLSSVL...TAMSRSSDIQRGITRIF........HRTA..KATEFIAVME.AILLAGK 35 .SES..SVFEQIE...NLLRKLPDVERGLCSIY........HKKC..STQEFFLIVK.SLCQLKS 36 .---..-------...-----------------........----..----------.------- 37 .SES..SVFEQIE...NLLRKLPDVERGLCSIY........HKKC..STQEFFLIVK.SLCQLKS 38 .SES..SVFEQIE...NLLRKLPDVERGLCSIY........HKKC..STQEFFLIVK.SLCQLKS 39 .SES..SVFEQIE...NLLRKLPDVERGLCSIY........HKKC..STQEFFLIVK.SLCQLKS 40 .SES..SVFGQIE...NHLRKLPDIERGLCSIY........HKKC..STQEFFLIVK.TLYHLKS 41 .SES..SVFGQIE...NHLRKLPDIGRGLCSIY........HKKC..STQEFFLIVK.TLYHLKS 42 .NSN..SQVQAIR...KMLYRLPDLEKGLSRIYyqr13afsKNSY..SCFKSALLRR.LIQQLPS 43 .NSN..SQVQAIR...KMLYRLPDLEKGLSRIYyqr13afsKNSY..SCFKSALLRR.LIQQLPS 44 .DAS..SFMTTAT...ATLKKIPDLDRLLQKIHtig23tikTNQK..KIAELLAAID.GFKLCNK 45 .RMP..TELQEVR...ALLAPMPDFERNLAQIHlfg24eklYNKQ..KLQGFMAVLK.GFNDLTK 46 .VVP..DKISEVV...ELLKKLPDLERLLSKIHnvg23ettYSKK..KIIDFLSALE.GFKVMCK 47 .VVP..DKISEVV...ELLKKLPDLERLLSKIHnvg23ettYSKK..KIIDFLSALE.GFKVMCK 48 .VVP..DKISEVV...ELLKKLPDLERLLSKIHnvg23ettYSKK..KIIDFLSALE.GFKVMCK 49 .VVP..DKISEVV...ELLKKLPDLERLLSKIHnvg23ettYSKK..KIIDFLSALE.GFKVMCK 50 .VVP..DKISEVV...ELLKKLPDLERLLSKIHnvg23ettYSKK..KIIDFLSALE.GFKVMCK 51 .AVP..DKVTEVA...DLLKKLPDLERLLSKIHnvg23ettYSKK..KIIDFLSALE.GFKVMCK 52 .AVP..YKVTEVA...DLLKKLPDLERLLSKIHnvg23ettYSKK..KIIDFLSALE.GFKVMCK 53 .QNC..GLGPTTL...GYLQKIPDLERLLGQVRst......VGLS..SLLQLPFIGE.------- 54 .QNC..GLGPTTL...GYLQKIPDLERLLGQVRst......VGLS..SLLQLPFIGE.------- 55 .---..-------...-----------------........----..----------.------- 56 .ANS..ESMQITG...QYLHKLPDLERLLGRIK........SSVR..SSASVLPALL.GKKVL-- 57 .---..-------...-----------------........----..----------.------- 58 .---..-------...-----------------........----..----------.------- 59 .GVGq.DCAAQFR...KDLSRLPDMERLLARLFssc14vvlYEDA..SKKLLQQFTS.ALCGCQQ 60 .ENL..PYSLEFR...KSLSRLPDMERLIARMFssi15vvlYEDT..AKKQVQEFIS.TLRGCET 61 .ENL..PYSLEFR...KSLSRLPDMERLIARMFssi15vvlYEDT..AKKQVQEFIS.TLRGCET 62 .DNP..VIRDTIW...GFLHKLPDLERLISRVH........AGRS..KPADFVRVLE.GFQRINS 63 .QDI..TLREQLE...ITFSKLPDLERMLARIH........SRTI..KVKDFEKVIT.AFETIIE 64 .QDI..TLREQLE...ITFSKLPDLERMLARIH........SRTI..KVKDFEKVIT.AFETIIE 65 .HRP..HILKTLR...ATLSCVRDVERLVARVA........LEKA..HGRDLLALKE.SLRAILT 66 .REG..ALREGVR...RLLYRLADLERLATRLE........LGRA..SPKDLGALRR.SLQILPE 67 .REG..ALREGVR...RLLYRLADLERLATRLE........LGRA..SPKDLGALRR.SLQILPE 68 .REG..ALREGVR...RLLFRLADLERLATRLE........LSRA..SPRDLAALRR.SLEILPE 69 .REG..ALREGVR...RLLFRLADLERLATRLE........LSRA..SPRDLAALRR.SLEILPE 70 .REG..ALREGVR...RLLFRLADLERLATRLE........LSRA..SPRDLAALRR.SLEILPE 71 .REG..ALREGVR...RLLFRLADLERLATRLE........LSRA..SPRDLAALRRrSLEILPE 72 .HHP..ALRQDLR...QLLRQIYDLERLTGRIG........ANTA..SARDVYGLAS.SLVRLTD 73 .HHP..ALRQDLR...QLLRQIYDLERLTGRIG........ANTA..SARDVYGLAS.SLVRLTD 74 .RQV..TLRKNIK...TYLCQVRDIERLMTKVT........TGLA..GPRDIGTLRD.SFSAGAQ 75 .RQV..TLRKNIK...TYLCQVRDIERLMTKVT........TGLA..GPRDIGTLRD.SFSAGAQ 76 .QQA..DLRKILK...RQLSCVRDLERLATKIS........TSLA..TPKDIGTLRD.SLLSCTH 77 .---..-------...-----------------........----..----------.------- 78 .---..-------...-----------------........----..----------.------- 79 .KQE..PLRKTLK...RHLSCVRDLERLATKIS........TTLA..SPKDIGMLRD.SLLSCMH 80 .SQY..KPLQ---...CRLKNIADIERIAARIA........VGNA..RPRDLASLRD.SLFELAQ 81 .SQY..KPLQ---...CRLKSIADIERIAARIA........VGNA..RPRDLAALRD.SLFALSE 82 .N-F..DLVDELQ...PYLQLVGDMERILARVA........LRSA..RPRDLTRLRT.ALEQIPA 83 .---..DFTAELQ...PVLRQVGDLERILARLA........LRTA..RPRDLARMRH.AFQQLPE 84 .---..DFTAELQ...PVLRQVGDLERILARLA........LRTA..RPRDLARMRH.AFQQLPE 85 .---..DFTAGLQ...PVLRQVGDLERILARLA........LRTA..RPRDLARMRH.AFQQLPE 86 .D--..-TVSELQ...PVLRQVGDLERTPCASGaaqpsa..RSRP..NA-------S.RLPAAAE 87 .D--..-TVSELQ...PVLRQVGDLERTPCASGaaqpsa..---R..SRPNASRLPA.AAELHAQ 88 .QDY..R-FESLQ...PQLKEIGDVERILARIG........LRNA..RPRDLARLRD.ALAALPQ 89 .ERY..R-FENLQ...PQLKEIGDLERILARIG........LRNA..RPRDLARLRD.ALAALPD 90 .ERY..R-FENLQ...PQLKEIGDLERILARIG........LRNA..RPRDLARLRD.ALAALPD 91 .---..----DVS...PVMIKVVDAAVQKARIG........LRNA..RPRDLARLRD.ALGALPE 92 .---..-------...-----------------........----..----------.------- 93 .---..-------...-----------------........----..----------.------- 94 .---..-------...-----------------........----..----------.------- 95 .---..-------...-----------------........----..----------.------- 96 .---..-------...-----------------........----..----------.------- 97 .---..-------...-----------------........----..----------.------- 98 .---..-------...-----------------........----..----------.------- 99 .---..-------...-----------------........----..----------.------- 100 .---..-------...-----------------........----..----------.------- 101 .DQP..RFTTDVR...DALRRAPDMPRALSRLA........LGRG..GPRDLGAIQA.GMRAAAA 102 .D-R..DLDNKLM...ETFRRLGDMERILTRVA........LRSA..RPRDISTLRD.SLSLLPR 103 .---..-------...-----------------........----..----------.------- 104 .---..-------...-----------------........----..----------.------- 105 .AHF..IERDTLR...TYLNQVYDIERLVGRVS........YGNV..NARDLIQLKH.SISEIPN 106 .SHF..FEREDLR...ERLKEVYDLERLAGRVA........FGNV..NARDLIQLKE.SLKQVPG 107 .SHF..FEREDLR...ERLKEVYDLERLAGRVA........FGNV..NARDLIQLKE.SLKQVPG 108 .DHF..FERSDLT...DSLKGVYDIERLASRVS........FGKT..NPKDLLQLAT.TLSSVPR 109 .NKR..EVLNEIR...KTLEGMSDLERLVSRIS........SNMA..SPRELIHLKN.SLRKAEE 110 .ENR..EALLKIR...QILEGMADLERLVSKIS........SNMA..TPRELVYLKN.SLKKVEE 111 .NDR..VSLEEMR...NLLSNVRDVERIVSRVE........YNRS..VPRDLVALRE.TLEIIPK 112 .NDR..VSLEEMR...NLLSNVRDVERIVSRVE........YNRS..VPRDLVALRE.TLEIIPK 113 .SNL..GIVTRIR...ELLKNTSDIERCLTRIT........MNRS..SGRDLLSIKY.TLETAKT 114 .DQI..ELRQMLTs..EYLPMIPDIRRLTKKLN........-KRG..NLEDVLKIYQ.FSKRIPE 115 .DQI..ELRQMLTs..EYLPMIPDIRRLTKKLN........-KRG..NLEDVLKIYQ.FSKRIPE 116 .MDV..ELRQCLQe..DLLRRFPDLNRLAKKFQ........RQTA..NLQDCYRLYQ.AVNHLPT 117 .EDS..ELRRALQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GVKQLPN 118 .EDS..ELRQSLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPS 119 .EDS..ELRQSLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPS 120 .EDA..ELRQTLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPN 121 .EDA..ELRQTLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPN 122 .EDA..ELRQTLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPN 123 .EDA..ELRQTLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPN 124 .EDA..ELRQTLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPN 125 .EDA..ELRQTLQ...-----------------........----..----------.------- 126 .EDA..ELRQTLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPN 127 .NDT..ELRQSMQe..EHLRSIPDLYRLSKRFQ........RGKA..TLEDVVRAYQ.VVIRLPG 128 .---..-------...-----------------........----..----------.------- 129 .EDA..EARQLLLdddHLLRSIPDIPKLCRRLT........RGSA..SLEDVVRIYQ.MAKALPK 130 .EDA..EARQLLLdddHLLRSIPDIPKLCRRLT........RGSA..SLEDVVRIYQ.MAKALPK 131 .EDP..ELRQGLR...QQLKRISDIDRLTHSLR........KKSA..NLQPVVKLYQ.SCSRIPY 132 .---..-------...-----------------........----..----------.------- 133 .EEA..GLRQDLR...QHLKRISDVERLLRSLE........RRRG..GLQHIIKLYQ.SAIRLPF 134 .EEA..GLRQDLR...QHLKRISDVERLLRSLE........RRRG..GLQHIIKLYQ.STIRLPF 135 .ESP..DTMETLSl..DYLKRLKQMVE------........----..----------.------- 136 .ESP..DTMETLSl..DYLKRIPDILMLTKKLM........RRKA..NLQDLFRIYQ.VILRTPK 137 .ESP..DTMETLSl..DYLKRIPDILMLTKKLM........RRKA..NLQDLFRIYQ.VILRTPK 138 .QDWnaEVTAKLS...SILGRVKALNSVFQKFQ........SGTA..QLIHWECFVS.TVNALVE 139 .QDWnaEVTAKLS...SILGRVKALNSVFQKFQ........SGTA..QLIHWECFVS.TVNALVE 140 .EYR..NLWEIFL...NHSKFSPDSEYLSEKIFlkk96kfqSGTA..QLIHWECFVS.TVNALVE 141 .---..-------...-----------------........----..----------.------- 142 .QNL..DMAQMLH...RLLSHIKNVPLILKRMK........LSHT..KVSDWQVLYK.TVYSALG 143 .QNL..DMAQMLH...RLLSHIKNVPLILKRMK........LSHT..KVSDWQVLYK.TVYSALG 144 .QNL..DMAQMLH...RLLGHIKNVPLILKRMK........LSHT..KVSDWQVLYK.TVYSALG 145 .QNL..DMAQMLH...RLLGHIKNVPLILKRMK........LSHT..KVSDWQVLYK.TVYSALG 146 .---..-------...-----------------........----..----------.------- 147 .QNL..DMAQMLH...RLLGHIKNVPLILKRMK........LSHT..KVSDWQVLYK.TVYSALG 148 .QNA..IIFSDLS...QSIKRCPDAFGFINQLR........SGKS..TLGTWSKVAS.FLEKGIA 149 .QNA..IIFSDLS...QSIKRCPDAFGFINQLR........SGKS..TLGTWSKVAS.FLEKGIA 150 .RLL..NQKIFDN...SELKCIKDLSSLHRQWAicass...DTTL..PPKKLSQIYH.SYLFACQ 151 .RLL..NQKIFDN...SELKCIKDLSSLHRQWAicass...DTTL..PPKKLSQIYH.SYLFACQ 370 380 390 | | | 1 INRLLKSE........ITEI........Lk.....KVERF..QVL.CDE...FFD........FD 2 VKKLFDKH........NFDY........W......NFDKF..EED.SISkvyFLI........NS 3 IRKYLLNN........TSLMkat16slnF......EKNLI..DDI.LKF...LNEeel30esnKD 4 IRKYLLNN........TSLMkat16slnF......EKNLI..DDI.LKF...LNEeel30esnKD 5 IHSLLSPLess10lllLNMH........P......HDELK..QLI.NNA...VDEnal43sefDI 6 --------........----........-......-----..---.---...---........-- 7 IHSLLSPLess10lllLNMH........P......HDELK..QLI.NNA...VDEnal43sefDI 8 ---LSGDE........VLTL........L......NQGMT..AKL.ERI...---........-- 9 IEEKLERF........KLTL........S......GKELV..EFL.RSL...RYG........DV 10 IEEKLEDF........KLTL........S......GRELV..EFI.RAL...RSG........DI 11 TFQKLRKAaisdnrv.TPLV........D......ILQGC..DFK.DTL...QQK........IS 12 VKRAIETN........SRGP........LrdvatgLGDHS..ELV.RRV...L--........-- 13 LLRFFENL........QLDLkaa15rfmP......LSELIvhPVI.NRS...FVK........LV 14 LRRVIEER........DDLE........I......LQTLV..AEV.RTLpe.LEQ........AI 15 MKHFITQMaedg....VDIP........L......IHQHA..EQL.ITLsd.LER........DI 16 FKTFYNQLveedegv.KYPI........L......DDKMN..QLP.VLT...DLF........QQ 17 LKKEFEKR........EYSR........L......KETFS..RLSsFRE...FVE........EV 18 IRRVLSSH........VQRLe.......P......LRKVY..KKL.YTFsp.LEN........LI 19 FLHKNSDI........KHLNvqi12lnpE......LKNLL..NEL.KEH...IDV........DA 20 LQNAFKTF........THLK........F......HERLN..AIV.LPP...FFN........DL 21 LQNAFKPF........THLK........F......HERLN..AII.LPP...FFN........DL 22 FEKLKKIK........LGTN........L......GSWLQ..KIE.FVS...GAL........EL 23 FEKLKKIK........LGTN........L......DSWLQ..KIE.FVS...GAL........EL 24 LKDALNDQ........LIQSrli20iekL......INSCI..NED.CVW...ASS........AI 25 LKDALNDQ........LIQSrli20iekL......INSCI..NED.CVW...ASS........AI 26 IRKSIQNV........SSHLlvq18llaI......INEYI..RND.CQW...ANN........ST 27 LKIAMKNC........NTPLlra18ileK......IKTVI..NDD.ARY...MKG........CL 28 LKIAMKNC........NTPLlra18ileK......IKTVI..NDD.ARY...MKG........CL 29 IRTLLHSA........KMKSnil21mniL......VEKVD..DSL.LDG...KKN........SL 30 HFKMHQSY........LSEHfks32qlpH......FLTMI..NVS.AVM...EKN........SD 31 HFKMHQSY........LSEHfks32qlpH......FLTMI..NVS.AVM...EKN........SD 32 PVSSSPGL........RVLNf.......L......DEKFI..AVM.EAI...LLAgkq55keaAV 33 PGSSSPGL........RVLNf.......L......DEKFI..AVM.EAI...LLAgkq55keaAV 34 QIQRLGIKqds10mqs----atvrst..L......LRKLI..SVI.SSP...VVVdna14keaAV 35 ELQALMPA........VNSHvqs11livE......LLSPV..EHY.LKV...LNG........PA 36 --------........----........-......-----..---.---...---........-- 37 ELQALMPA........VNSHvqs11livE......LLSPV..EHY.LKV...LNG........PA 38 ELQALMPA........VNSHvqs11livE......LLSPV..EHY.LKV...LNG........PA 39 ELQALMPA........VNSHvqs11livE......LLSPV..EHY.LKV...LNG........PA 40 EFQAIIPA........VNSHiqs14eipE......LLSPV..EHY.LKI...LNE........QA 41 EFQAIIPA........VNSHiqs14eipE......LLSPV..EHY.LKI...LNE........QA 42 ISSIIDHF........LGMF........D......QKEAE..NNN.KVD...MFKdi......DN 43 ISSIIDHF........LGMF........D......QKEAE..NNN.KVD...MFKdi......DN 44 LRKEYIKV........QKEG........E......GCELL..DEL.LGN...EQEmee16mfdRS 45 LPTMFHQC........KTTLlkr12sggS......FPDLS..KEL.QYF...ATA........FD 46 IIGIMEEV........ADGFksk18pegR......FPDLT..VEL.NRW...DTA........FD 47 IIGIMEEV........ADGFksk18pegR......FPDLT..VEL.NRW...DTA........FD 48 IIGIMEEV........ADGFksk18pegR......FPDLT..VEL.NRW...DTA........FD 49 IIGIMEEV........ADGFksk18pegR......FPDLT..VEL.NRW...DTA........FD 50 IIGIMEEV........ADGFksk18pegR......FPDLT..VEL.NRW...DTA........FD 51 VSGLLEEV........AGGFtsk18pkgR......FPDLT..AEL.QRW...DTA........FD 52 VSGLLEEV........AGGFtsk18pkgR......FPDLT..AEL.QRW...DTA........FD 53 --------........----........-......-----..---.---...--K........II 54 --------........----........-......-----..---.---...--K........II 55 --------........----........-......-----..---.---...---........-- 56 --------........----........-......-----..---.---...---........-- 57 --------........----........-......-----..---.---...---........-- 58 --------........----........-......-----..---.---...---........-- 59 MFHACSSI........STLIcse16gkg-......LSNIS..SIL.DRFrd.AFD........WS 60 MAEACSSLrai10tsr----rll13slpN......ISSSI..KY-.FKD...AFD........WV 61 MAEACSSLrai11srr----llhl....L......TPGII..NLL.HIH...ILIlan32afdWV 62 AFDQLREE........FMEVaeg11iiqS......APNMK..EEL.EAW...TRA........FN 63 LQDSLKNNdlkgdvskYISS........F......PEGLV..EAV.KSW...TNA........FE 64 LQDSLKNNdlkgdvskYISS........F......PEGLV..EAV.KSW...TNA........FE 65 FRSLERES........PFPPdll10dtpV......LQELY..GLL.EQS...IKE........DC 66 LRALLGEE........VGLP........D......LSPLK..EEL.EAA...LVE........DP 67 LRALLGEE........VGLP........D......LSPLK..EEL.EAA...LVE........DP 68 LKGLLGEE........VGLP........D......LSGLL..EEL.RAA...LVE........DP 69 LKGLLGEE........VGLP........D......LSGLL..EEL.RAA...LVE........DP 70 LKGLLGEE........VGLP........D......LSGLL..EEL.RAA...LVE........DP 71 LEGLLGEE........VGLP........D......LSGLL..EEL.RAA...LVE........DP 72 LAELAQEGhsp9kalqTVPP........E......LEELG..KYV.LAH...IVE........NP 73 LAELAQEGhsp9kalqTVPP........E......LEELG..KYV.LAH...IVE........NP 74 IYEQLASA........TLPEffidkcsl-dtk...LASLI..ALL.SKS...LNG........DL 75 IYEQLASA........TLPEffidkcsl-dtk...LASLI..ALL.SKS...LNG........DL 76 IADNLQNC........ALPEfle10iapP......LCSLI..KTL.STE...LIQ........EL 77 --------........----........-......-----..---.---...---........-- 78 --------........----........-......-----..---.---...---........-- 79 IAHDLQSY........TLPEflt10issS......LKSLI..EAL.STD...LLQ........EL 80 IDLSANGS........SLLEtlkavfp.E......NLSTA..EQL.RQA...ILP........EP 81 IELSAECSsl......LG--tlkavfp.E......NLSTA..EQL.RQA...ILP........EP 82 LRAIVQQK........TPPFlta9sqiaD......FSEQC..DLL.QRA...LIE........TP 83 LRAQLETV........DSAPvqa9ekmgE......FAELR..DLL.ERA...IID........TP 84 LRAQLETV........DSAPvqa9ekmgE......FAELR..DLL.ERA...IID........TP 85 LRAQLETV........DSAPvqa9ekmgE......FAELR..DLL.ERA...IID........TP 86 LHAQLETV........DSAPvqa9kkmgD......FAELR..DLL.ERA...IID........AP 87 LETVDSAP........VQRCvkkw....A......ISPSC..ATS.WNA...PLL........TR 88 LQTALSPL........EAPHlqa9gnirT......YPELA..ELL.RRA...IID........NP 89 LQNAMTEL........EAPHlqa9ttigT......YPELA..ELL.AKA...IID........NP 90 LQNAMTEL........EAPHlqa9ttigT......YPELA..ELL.AKA...IID........NP 91 LQNAMTEL........EAPHlar9aitgT......YPELA..SLL.ERA...IID........NP 92 --------........----........-......-----..---.---...---........-- 93 --------........----........-......-----..---.---...---........-- 94 --------........----........-......-----..---.---...---........-- 95 --------........----........-......-----..---.---...---........-- 96 --------........----........-......-----..---.---...---........-- 97 --------........----........-......-----..---.---...---........-- 98 --------........----........-......-----..---.---...---........-- 99 --------........----........-......-----..---.---...---........-- 100 --------........----........-......-----..---.---...---........-- 101 ISALLSGA........ELSAelt11iaaL......PGELL..ARL.DAT...LAE........EL 102 LRELLNAS........DSPRlrv9aelgE......HDSTA..SLL.VKA...VAE........QP 103 --------........----........-......-----..---.---...---........-- 104 --------........----........-......-----..---.---...---........-- 105 IKALLNSMnqntlvqvNQLE........P......LDDLL..DIL.EQS...LVE........EP 106 IKQLVASL........AHDKake9kridP......CGDVL..ELL.EEA...LYE........NP 107 IKQLVASL........AHDKake9kridP......CGDVL..ELL.EEA...LYE........NP 108 IRAILEGM........EQPTlay9aqldA......IPELE..SLI.SAA...IAP........EA 109 LRKILSLL........DSEIfke9gsllN......LNKVA..DLI.DKT...LVD........DP 110 LRLLLLEL........KAPIfke9qnfeD......TKKII..NDI.EKT...LVE........DP 111 LNEVLSTFgvf.....KKLA........F......PEGLV..DLL.RKA...IED........DP 112 LNEVLSTFgvf.....KKLA........F......PEGLV..DLL.RKA...IED........DP 113 IKGLFSES........YGLNlph11ikp-lsg...DAELY..NLI.HMS...IRE........DA 114 IVQVFTSFled22aplSHH-v.......E......PLSKF..EEM.VET...TVD........LD 115 IVQVFTSFled22aplSHH-v.......E......PLSKF..EEM.VET...TVD........LD 116 VVQAIEKY........EGTHqml17lssD......FSKFQ..EMI.ETT...L--........DM 117 VIQALEKY........QGRHqal17lrsD......FSKFQ..EKI.ETT...L--........DM 118 VIQALEKY........EGRHqal17lrsD......FSKFQ..EMI.ETT...L--........DM 119 VIQALEKY........EGRHqal17lrsD......FSKFQ..EMI.ETT...L--........DM 120 VIQALEKH........EGKHqkl17lrsD......FSKFQ..EMI.ETT...L--........DM 121 VIQALEKH........EGKHqkl17lrsD......FSKFQ..EMI.ETT...L--........DM 122 VIQALEKH........EGKHqkl17lrsD......FSKFQ..EMI.ETT...L--........DM 123 VIQALEKH........EGKHqkl17lrsD......FSKFQ..EMI.ETT...L--........DM 124 VIQALEKH........EGKHqkl17lrsD......FSKFQ..EMI.ETT...L--........DM 125 --------........----........-......-----..---.---...---........-- 126 VIQALEK-........----........-......-----..---.---...---........-- 127 FIGTLEGV........MDEAyrd18lsdS......LVKLQ..EMV.ETT...V--........DL 128 --------........----........-......-----..---.---...---........-- 129 IVTVLDSL........TSEHkdl17hckN......LEKLI..ELV.ETT...I--........DL 130 IVTVLDSL........TSEHkdl17hckN......LEKLI..ELV.ETT...I--........DL 131 IKGILQQY........NGQFstl.....I......RSKFL..EPL.EEW...MAKnrf14taiDL 132 --------........----........-......-----..---.---...---........-- 133 IKTAMQQY........TGEFasl19dqdH......LGKFI..DLV.ECS...V--........DL 134 IKTAMQQY........TGEFasl19dqdH......LGKFI..DLV.ECS...V--........DL 135 --------........----........-......-----..---.---...QVV........DF 136 ILKVLHELdns14pfkSFLK........D......LTGLK..QMV.EQV...V--........DF 137 ILKVLHELdns14pfkSFLK........D......LTGLK..QMV.EQV...V--........DF 138 ILNIIRQT........PISKefp9sdllR......EVSEI..AVI.AGS...IIN........FA 139 ILNIIRQT........PISKefp9sdllR......EVSEI..AVI.AGS...IIN........FA 140 ILNIIRQT........PISKefp9sdllR......EVSEI..AVI.AGS...IIN........FA 141 --------........----........-......-----..---.---...---........-- 142 LRDACRSL........PQSIqlf11efsD......DLHHI..ASL.IGK...VVD........FE 143 LRDACRSL........PQSIqlf11efsD......DLHHI..ASL.IGK...VVD........FE 144 LRDACRSL........PQSIqlf11efsD......DLHHI..ASL.IGK...VVD........FE 145 LRDACRSL........PQSIqlf11efsD......DLHHI..ASL.IGK...VVD........FE 146 --------........----........-......-----..---.---...---........-- 147 LRDACRSL........PQSIqlf11efsD......DLHHI..ASL.IGK...VVD........FE 148 IFQLVSSL........KLGSdea13nkvD......ISALK..ECL.RKVet.VID........FD 149 IFQLVSSL........KLGSdea13nkvD......ISALK..ECL.RKVet.VID........FD 150 LISKLTNN........IQLPplvgp...Q......LKSLI..KEI.ERI...FQV........DS 151 LISKLTNN........IQLPplvgp...Q......LKSLI..KEI.ERI...FQV........DS 400 410 420 430 4 | | | | 1 YEKENKEIRVRV..DFVPEIQEIS.EKLEQMERVAEKLRKKYSAKF.......ECD.......NL 2 AISSAPDELIKR..GYDLKLDNLK.DLKINANKYIDQYLESERLLS.......KIN.......NL 3 EIFELRDFIVNP..SFNTKLRKLH.DTYQGVWQKKTEYNALLKGFFvgdl...GAK.......TF 4 EIFELRDFIVNP..SFNTKLRKLH.DTYQGVWQKKTEYNALLKGFFvgdl...GAK.......TF 5 RQSFKENWVVKS..NFNNNLRKLH.EKLQSLFASYDKLQEDLSKRL.......GKK.......-A 6 ------------..----------.---------------------.......---.......-- 7 RQSFKENWVVKS..NFNNNLRKLH.EKLQSLFASYDKLQEDLSKRL.......GKK.......-A 8 ------------..----------.---------FDDVLSEARSMI.......KKR.......SG 9 EAILSKFSSLND..DI--------.------IEEIRKAEEKLSQEL.......GVA.......-- 10 EVVLSKFSALND..----------.----EILDEIKKTEEELSKEL.......GID.......-- 11 FCIDCNMTMILD..RASEDLEIIR.SERRRNMENLDSLLKKISTKIfla....---ggi....NK 12 -QSLDREGNVRD..DASPRLRDLR.KRIEPLRGRIREKLTQTLEKWs......DVL.......QE 13 EQVIDPDGTIKD..SASSALRQSR.ERVQTLERKLQQLLDAIIRSQ.......KDDesvmi..KF 14 HHCLGEDGKVAE..RASPKLGEIR.QKLKAVREQIQQKLQKIIQRQ.......SNAl......QE 15 NSCIDDHGEVLD..HASETLRGIR.TQLRTLESRVRDRLESMLRSS.......SASkml....SD 16 INETCDTYDLYD..NASYELQGIR.SKISSTNQRIRQNLDRIVKSQa......-NQkkl....SD 17 NRCIEQDGEISD..RASPRLREIR.TEKKRLSSEIKRKADDFVRTHs......QIL.......QE 18 IGSIDPRGFVKD..EASEELLRVR.KSIRAVEEEIKKRLDNLINRP.......DSAkfl....SD 19 LELKSGVVKEYD..SIEFEIKNLN.RRVENQIKKIISLNAEYL---.......---.......TS 20 IALFDDEGKIKQ..GANATLDALN.ESLNRLKKESVKIIHHYARSK.......ELApy.....LV 21 ILLLDDEGQIKQ..GANATLDALN.ESLNRLKKESTKIIHHYAHSK.......ELApy.....LV 22 CLNFDEKGELKE..SLDERLVNLN.AALRLKNESIIAEFKKFCYTK.......ALMpy.....LI 23 CLNFDEKGELKE..SLDERLVNLN.AALRLKNESIIAEFKKFCYTK.......ALMpy.....LI 24 QLLNQRSYAVKS..DSNGLLDVSR.QIYKEVKEEFFREVEDLTAKN.......KI-.......NL 25 QLLNQRSYAVKS..DSNGLLDVSR.QIYKEVKEEFFREVEDLTAKN.......KI-.......NL 26 ELANQRANAVKS..GVNGLLDVSR.RIRETLLEEVSELVAKLSEEL.......EIF.......-M 27 NMRTQKCYAVRS..NINEFLDIAR.RTYTEIVDDIAGMISQLGEKY.......SLP.......-L 28 NMRTQKCYAVRS..NINEFLDIAR.RTYTEIVDDIAGMISQLGEKY.......SLP.......-L 29 HLQNTKCYAIRH..FVAVQLDLAR.QTYEEIIRNVEETGAREIAEYfh.....GNS.......SV 30 KQVMDFFNLNNY..DCSEGIIKIQ.RESESVRSQLKEELAEIRKYL.......KRP.......YL 31 KQVMDFFNLNNY..DCSEGIIKIQ.RESESVRSQLKEELAEIRKYL.......KRP.......YL 32 RGDLLDILITSS..DQFPELAEAR.QAVLVIREKLDSSIASFRKKL.......AIR.......NL 33 RGDLLDILITSS..DQFPELAEAR.QAVLVIREKLDSSIASFRKKL.......AIR.......NL 34 RGDLLDILITSS..DQFPELAEAR.QAVLVIREKLDSSIASFRKKL.......AIR.......NL 35 AKVGDKTELFKD..LSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL.......KLP.......SL 36 ------------..----------.---------------------.......---.......-- 37 AKVGDKTELFKD..LSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL.......KLP.......SL 38 AKVGDKTELFKD..LSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL.......KLP.......SL 39 AKVGDKTELFKD..LSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL.......KLP.......SL 40 AKVGDKTELFKD..LSDFPLIKKRkDEIQGVIDEIRMHLQEIRKIL.......KNP.......SA 41 AKVGDKTELFKD..LSDFPLIKKRkDEIQGVIDEIRMHLQEIRKIL.......KNP.......SA 42 FDLSEEPNDVDY..ELAQEIRELK.MSILMVRTEMDFHLQELRDYL.......EYP.......NL 43 FDLSEEPNDVDY..ELAQEIRELK.MSILMVRTEMDFHLQELRDYL.......EYP.......NL 44 TAMKDGKIVPNA..GCDEEYDEAL.NRVKEALNELNDYKDSVAKKY.......SCS.......-I 45 HDAAAKTGVIAPqaGMDAEYDAAM.DSIGEVEKRLKTYLVEQERHF.......GCR.......-I 46 HEKARKTGLITPkaGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI.......GCR.......TI 47 HEKARKTGLITPkaGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI.......GCR.......TI 48 HEKARKTGLITPkaGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI.......GCR.......TI 49 HEKARKTGLITPkaGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI.......GCR.......TI 50 HEKARKTGLITPkaGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI.......GCR.......TI 51 HEKARKTGLITPkaGFDSDYDQAL.ADIRENEQSLLEYLDKQRSRL.......GCK.......SI 52 HEKARKTGLITPkaGFDSDYDQAL.ADIRENEQSLLEYLDKQRSRL.......GCK.......SI 53 KKRIKTFIMLIN..GLRNGIDLLN.DLQRADHGILA----------.......---.......LY 54 KKRIKTFIMLIN..GLRNGIDLLN.DLQRADHGILA----------.......---.......LY 55 ------------..----------.---------------------.......---.......-- 56 KQRVKAFGQIVK..GFRSGIDLLL.ALQKE--SNMMSLLYKLCKLP.......ILV.......GK 57 ------------..----------.---------------------.......---.......-- 58 ------------..----------.---------------------.......---.......-- 59 DADRNGRFIPYE..GCDPEFDATC.NAIEEIKSSLKEYLKEQRKLL.......RPA.......SV 60 EAHNSGRVIPHE..GADEEYDCAC.KTVEEFESSLKKHLKEQRKLL.......GDA.......SI 61 EAHNSGRVIPHE..GADEEYDCAC.KTVEEFESSLKKHLKEQRKLL.......GDA.......SI 62 WQKASEEGVFEPeiGFEAEYDTSQ.KYQSELKNELYALLEQYKKQL.......RCS.......SL 63 RQKAINENIIVPqrGFDIEFDKSM.DRIQELEDELMEILMTYRKQF.......KCS.......NI 64 RQKAINENIIVPqrGFDIEFDKSM.DRIQELEDELMEILMTYRKQF.......KCS.......NI 65 PVTLSDGNLIKR..GFSASLDELH.RVRDNANEILKQYLAEERERT.......GIG.......TL 66 PLKVSEGGLIRE..GYDPDLDALR.AAHREGVAYFLELEERERERT.......GIP.......TL 67 PLKVSEGGLIRE..GYDPDLDALR.AAHREGVAYFLELEERERERT.......GIP.......TL 68 PLKVSEGGLIRE..GYDPDLDALR.RAHAEGVAYFLDLEAREKERT.......GIP.......TL 69 PLKVSEGGLIRE..GYDPDLDALR.RAHAEGVAYFLDLEAREKERT.......GIP.......TL 70 PLKVSEGGLIRE..GYDPDLDALR.RAHAEGVAYFLDLEAREKERT.......GIP.......TL 71 PLKVSEGGVIRE..GYDPDLDALR.RAHADPVAYFLDLEVREKEST.......GIP.......TL 72 PLHIREGNLIRS..GVNPTLDEMR.QSLEDDNQWLANLEVTEREKT.......GIA.......NL 73 PLHIREGNLIRS..GVNPTLDEMR.QSLEDDNQWLANLEVTEREKT.......GIA.......NL 74 PLRVSDGNIFVD..EFHNDLKRLR.HNQEHSQEWIWEYQERIRKET.......GIK.......KL 75 PLRVSDGNIFVD..EFHNDLKRLR.HNQEHSQEWIWEYQERIRKET.......GIK.......KL 76 PLKVSEGNIFAN..HYHPDLLRLR.NIKENSKSWILEYQERIRNET.......GIK.......KL 77 ------------..----------.---------------------.......---.......-- 78 ------------..----------.---------------------.......---.......-- 79 PLKVSEGNIFAD..HYHQDLLRLR.NIKTNSKSWILEYQERIRQET.......GIK.......KL 80 SVWLKDGNVINH..GFHPELDELR.RIQNHGDEFLLDLEAKERERT.......GLS.......TL 81 SVWLKDGNVINH..GFHPELDELR.RIQNHGDEFLLDLEAKERERT.......GLS.......TL 82 PLLIRDGGVIAE..GYNAELDEWR.MLSDGATQYLENLEKREREST.......GID.......TL 83 PVLVRDGGVIAS..GYNEELDEWR.ALADGATDYLERLEVRERERT.......GLD.......TL 84 PVLVRDGGVIAS..GYNEELDEWR.ALADGATDYLERLEVRERERT.......GLD.......TL 85 PVLVRDGGVIAS..GYNEELDEWR.ALADGATDYLERLEVRERERT.......GLD.......TL 86 PVLVRDGAVIAP..GYHEELDEWR.ALADGATDYLDRLEIRERERT.......GLD.......TL 87 RRYWSRRRVIAP..GYHEELDEWR.ALADGATDYLDRLEIRERERT.......GLD.......TL 88 PAVIRDGGVLKQ..GYDAELDELL.SLSENAGQFLMDLEAREKART.......GLP.......NL 89 PAVIRDGGVIKT..GYDAELDELQ.ALSENAGQFLMDLEAREKART.......GLP.......NL 90 PAVIRDGGVIKT..GYDAELDELQ.ALSENAGQFLMDLEAREKART.......GLP.......NL 91 PAVIRDGGVLKA..GYDNELDEML.AISENAGQFLIDLEAREKART.......GLA.......NL 92 ------------..----------.---------------------.......---.......-- 93 ------------..----------.---------------------.......---.......-- 94 ------------..----------.---------------------.......---.......-- 95 ------------..----------.---------------------.......---.......-- 96 ------------..----------.---------------------.......---.......-- 97 ------------..----------.---------------------.......---.......-- 98 ------------..----------.---------------------.......---.......-- 99 ------------..----------.---------------------.......---.......-- 100 ------------..----------.---------------------.......---.......-- 101 PLLKRDGGFVRE..GASAELDEMR.ALRDQSRRVIAGLQLQYCEET.......GIK.......SL 102 PLKLTDGGVIAS..EYDVELDELR.KLSNNADQFLIDLETRERESS.......GIS.......TL 103 ------------..----------.---------------------.......---.......-- 104 ------------..----------.---------------------.......---.......-- 105 PISVKDGGLFKV..GFNTQLDE--.---------------------.......---.......-- 106 PLSVKEGNLIKD..GYNQKLDEYR.DASRNGKDWIARLEQQEREYT.......GIR.......SL 107 PLSVKEGNLIKD..GYNQKLDEYR.DASRNGKDWIARLEQQEREYT.......GIR.......SL 108 PHVITDGGIIRT..GFDETLDKYR.CVLREGTSWIAEIEAKERENS.......GIS.......TL 109 PLHVKEGGLIKP..GVNAYLDELR.FIRENAEKLLKEYEKKLKKET.......GIQ.......SL 110 PLHVKEGGLIRE..GVNAYLDELR.FIRDNAETYLREYEKKLRQET.......GIQ.......SL 111 VGSPGEGKVIKR..GFSSELDEYR.DLLEHAEERLKEFEEKERERT.......GIQ.......KL 112 VGSPGEGKVIKR..GFSSELDEYR.DLLEHAEERLKEFEEKERERT.......GIQ.......KL 113 PNNLNDGGIIKY..EFHPKIAQLN.DLINNKKLHVEKLKDQYRKET.......RIE.......SL 114 AYEENNEFMIKV..EFNEELGKIR.SKLDTLRDEIHSIHLDSAEDL.......GFDpdk....KL 115 AYEENNEFMIKV..EFNEELGKIR.SKLDTLRDEIHSIHLDSAEDL.......GFDpdk....KL 116 DQVENHEFLVKA..SFDPNLTELR.EKMDELEKNMQGALGGAAREL.......GLDagk....SI 117 DQVENHEFLVKP..SFDPNLSELR.EVMDGLEKKMQSTLISAARGL.......GLDpgk....QI 118 DQVENHEFLVKP..SFDPNLSELR.EVMDGLEKKMQSTLINAARGL.......GLDpgk....QI 119 DQVENHEFLVKP..SFDPNLSELR.EVMDGLEKKMQSTLINAARGL.......GLDpgk....QI 120 DQVENHEFLVKP..SFDPNLSELK.---------------------.......---.......-- 121 DQVENHEFLVKP..SFDPNLSELR.EIMNDLEKKMQSTLISAARDL.......GLDpgk....QI 122 DQVENHEFLVKP..SFDPNLSELR.EIMNDLEKKMQSTLISAARDL.......GLDpgk....QI 123 DQVENHEFLVKP..SFDPNLSELR.EIMNDLEKKMQSTLISAARDL.......GLDpgk....QI 124 DQVENHEFLVKP..SFDPNLSELR.EIMNDLEKKMQSTLISAARDL.......GLDpgk....QI 125 ------------..----------.---------------------.......---.......-- 126 ------------..----------.---------------------.......---.......-- 127 DALDNHEFIIKP..EFDDSLRIIR.KKLDRLRTDMDNEFAEAAEDL.......GQErek....KI 128 ------------..----------.---------------------.......---.......-- 129 EALDSHQYIIRA..EFDEELLDLR.QRLDELQHSIFEEHKRVGSDL.......HQDtek....KL 130 EALDSHQYIIRA..EFDEELLDLR.QRLDELQHSIFEEHKRVGSDL.......HQDtek....KL 131 AQLENGEYRISP..LYSSDLGVLK.DELSVVENHINNLHVDTASDL.......DLSvd.....KQ 132 ------------..----------.---------------------.......---.......-- 133 DQLENGEYMISS..NYDTKLASLK.DQKELLEQQIHELHKKTAIEL.......DLQvdk....AL 134 DQLENGEYMISS..SYDTKLASLK.DQKELLEQQIHELHKKTAIEL.......DLQvdk....AL 135 EAIERGEYLVKA..SFDSRLMELQ.QMMTELYSKMEELQFKCSQEL.......NLDgkn....QV 136 EAIERGEYLVKA..SFDSRLMELQ.QMMTELYSKMEELQFKCSQEL.......NLDgkn....QV 137 EAIERGEYLVKA..SFDSRLMELQ.QMMTELYSKMEELQFKCSQEL.......NLDgkn....QV 138 ESKIQGRVTVMN..GIDEELDEIR.DTYENMPMVLTAIAKQEEARL.......GLPpys....NV 139 ESKIQGRVTVMN..GIDEELDEIR.DTYENMPMVLTAIAKQEEARL.......GLPpys....NV 140 ESKIQGRVTVMN..GIDEELDEIR.DTYENMPMVLTAIAKQEEARL.......GLPpys....NV 141 ------------..----------.---------------------.......---.......-- 142 ESLAENRFTVLP..NIDPDIDAKK.RRLIGLPSFLTEVAQKELENLds.....RIP.......SC 143 ESLAENRFTVLP..NIDPDIDAKK.RRLIGLPSFLTEVAQKELENLds.....RIP.......SC 144 GSLAENRFTVLP..NIDPEIDEKK.RRLMGLPSFLTEVARKELENLds.....RIP.......SC 145 GSLAENRFTVLP..NIDPEIDEKK.RRLMGLPSFLTEVARKELENLds.....RIP.......SC 146 ------------..----------.---------------------.......---.......-- 147 GSLAENRFTVLP..NIDPEIDEKK.RRLMGLPSFLTEVARKELENLds.....RIP.......SC 148 TSRDTKTLTINT..GVDNRLDECR.NIYNHLEGILLDVARETQIFLlntmpqeDCKttkslekLV 149 TSRDTKTLTINT..GVDNRLDECR.NIYNHLEGILLDVARETQIFLlntmpqeDCKttkslekLV 150 LLGDFKDVIQPI..GNLPNLFEQR.QTLRAQLTEWAEQISNIV-FQ.......DTT.......SI 151 LLGDFKDVIQPI..GNLPNLFEQR.QTLRAQLTEWAEQISNIV-FQ.......DTT.......SI 40 450 460 470 48 | | | | 1 KLDKNSQYGFYFRVTL.....KEE....KS....IRKKdv......HILETTKGS...GVKFSVG 2 KIRKTNNRGLFFEVTK.....SNY....AQ....VPPH........FMESQALNS...SKRYKTE 3 TLKERQNGEYALHVTG.....TAS....SL....KKIDeli13gscFHILQKSSQ...TRWLSHK 4 TLKERQNGEYALHVTG.....TAS....SL....KKIDeli13gscFHILQKSSQ...TRWLSHK 5 TLRKSPAKLYYVHLKL.....SGN....ET....IERFikkftq..AVLFQSTKS...TASFQLP 6 ----------------.....---....--....----........------TKS...TASFQLP 7 TLRKSPAKLYYVHLKL.....SGN....ET....IERFikkftq..AVLFQSTKS...TASFQLP 8 VEFDPFIKSYPLKIDQ.....REV....ER....VKRLe.......---------...------- 9 --IEVFPRDYPVEVPP.....DVV....ER....LKR-........---------...------- 10 --VEVFPRDYPIEVPP.....EVV....ES....LRK-........---------...------- 11 PLITQRRSRMCVAIRA.....THK....SL....LPGGv.......VLSVSSSRA...TCFIEPK 12 HLVTIRRDRYVLPVLA.....SRV....GS....VQGI........IVDASATGQ...TYFVEPA 13 QLAAEIDGRWCIQMSS.....NQL....TS....VNGLlls14ledNMCFSGSGG...GTAAEPI 14 AVITQRGDRFVLPIKA.....GYK....EQ....MPGI........VHDSSASGN...TLYVEPQ 15 TIVTIRNDRFVIPVKQ.....EYR....SS....YGGI........VHDTSSSGA...TLFIEPQ 16 AIVTVRNERNVIPVKA.....EYR....QD....FNGI........VHDQSASGQ...TLYIEPS 17 QMYVYRDGRYLFPVKA.....SMK....NA....VRGI........VHHLSSSGA...TVFLEPD 18 RIVTIRNGRYVIPVKT.....SHV....KK....IFGI........VHGTSSSGY...TTYVEPQ 19 NFVCYKSNKYTLALKS.....NFK....GK....IKGN........IISISSSGE...TFYIEPN 20 DTQSHLKHGYECLLLK.....SGF....SG....AIKG........VVLERSANG...YFYLLPE 21 DTQSHLKHGYECLLLK.....SGF....SS....AIKG........VVLERSANG...YFYLLPE 22 DTQIHLINNLEALLVR.....GGF....NH....AIKA........KIIGRSSGG...GFYIVPL 23 DTQIHLINNLEALLVR.....GGF....NH....AIKA........KIIGRSSGG...GFYIVPL 24 DHNYDSARGFYLRIKR.....QEF....TDdvatLPDV........FISRTIKKN...YIECTTL 25 DHNYDSARGFYLRIKR.....QEF....TDdvatLPDV........FISRTIKKN...YIECTTL 26 EYRFEISRGFFIKIKG.....NNT....DIns..LPEV........LINRVKKRK...TIECTTI 27 RTSFSSARGFFIQMTT.....DCIalpsDQ....LPSE........FIKISKVKN...SYSFTSA 28 RTSLSSVRGFFIQMTT.....DCIalpsDQ....LPSE........FIKISKVKN...SYSFTSA 29 RLSFSQSRGFHYTFVT.....RQA....ESvt..IPRY........FLDVFRNRT...TVTFNSR 30 NFR--DEVDYLIEVKN.....SQI....KD....LPDD........WIKVNNTKM...VSRFTTP 31 NFR--DEVDYLIEVKN.....SQI....KD....LPDD........WIKVNNTKM...VSRFTTP 32 EFLQVSGITHLIELPV.....D--....SK....VPMN........WVKVNSTKK...TIRYHPP 33 EFLQVSGITHLIELPV.....D--....SK....VPMN........WVKVNSTKK...TIRYHPP 34 EFLQVSGITHLIELPV.....D--....SK....VPMN........WVKVNSTKK...TIRYHPP 35 QYVTVSGQEFMIEIKN.....SAV....SC....IPAD........WVKVGSTKA...VSRFHPP 36 ----------------.....---....--....----........---------...------- 37 QYVTVSGQEFMIEIKN.....SAV....SC....IPAD........WVKVGSTKA...VSRFHPP 38 QYVTVSGQEFMIEIKN.....SAV....SC....IPAD........WVKVGSTKA...VSRFHPP 39 QYVTVSGQEFMIEIKN.....SAV....SC....IPAD........WVKVGSTKA...VSRFHPP 40 QYVTVSGQEFMIEIKN.....SAV....SC....IPTD........WVKVGSTKA...VSRFHSP 41 QYVTVSGQEFMIEIKN.....SAV....SC....IPTD........WVKVGSTKA...VSRFHSP 42 EFSIWGNVKFCIEVSK.....GC-....KK....IPPD........WIKLSSTRS...LFRFHTP 43 EFSIWGNVKFCIEVSK.....GC-....KK....IPPD........WIKLSSTRS...LFRFHTP 44 KFVDSGKVKYLLEMPE.....N--....TK....VSSS........FELKSRRKG...FIRYSTP 45 TYFGSDKKRYQLDVPE.....SHA....SK....ANKS........YTLEGQTKGkkpSRRYTTA 46 VYWGIGRNRYQLEIPE.....NFT....TRn...LPEE........YELKSTKKG...CKRYWTK 47 VYWGIGRNRYQLEIPE.....NFT....TRn...LPEE........YELKSTKKG...CKRYWTK 48 VYWGIGRNRYQLEIPE.....NFT....TRn...LPEE........YELKSTKKG...CKRYWTK 49 VYWGIGRNRYQLEIPE.....NFT....TRn...LPEE........YELKSTKKG...CKRYWTK 50 VYWGIGRNRYQLEIPE.....NFT....TRn...LPEE........YELKSTKKG...CKRYWTK 51 VYWGIGRNRYQLEIPE.....NFA....TRn...LPEE........YELKSTKKG...CKRYWTK 52 VYWGIGRNRYQLEIPE.....NFA....TRn...LPEE........YELKSTKKG...CKRYWTK 53 KIVDIPSLSYLPELIH.....KFE....ER....MQNE........FPCGQV---...------- 54 KIVDIPSLSYLPELIH.....KFE....ER....MQNE........FPCGQV---...------- 55 ----------------.....---....--....----........---------...------- 56 SGLELFLSQFEAAIDS.....DFP....NY....QNQ-........---------...------- 57 ----------------.....---....--....----........---------...------- 58 ----------------.....---....--....----........---------...------- 59 NYVNVGKDMYLIEVPE.....SLG....GS....VPRN........YELQSTKKG...FYRYWTP 60 NYVTVGKDEYLLEVPE.....SLS....GS....VPHD........YELCSSKKG...VSRYWTP 61 NYVTVGKDEYLLEVPE.....SLS....GS....VPHD........YELCSSKKG...VSRYWTP 62 NFKNIGKEVYQVEVPS.....DV-....-K....VPVN........WCKMSGTKK...TNRYYND 63 QYKDSGKEIYTIEIPI.....SAT....KN....VPSN........WVQMAANKT...YKRYYSD 64 QYKDSGKEIYTIEIPI.....SAT....KN....VPSN........WVQMAANKT...YKRYYSD 65 KMKYNRMLGHFLEVSK.....GHL....SA....VPAH........FIRRRSLSN...ADRFTTE 66 KVGYNAVFGYYLEVTR.....PYY....ER....VPKE........YRPVQTLKD...RQRYTLP 67 KVGYNAVFGYYLEVTR.....PYY....ER....VPKE........YRPVQTLKD...RQRYTLP 68 KVGYNAVFGYYLEVTR.....PYY....EK....VPQE........YRPVQTLKD...RQRYTLP 69 KVGYNAVFGYYLEVTR.....PYY....EK....VPQE........YRPVQTLKD...RQRYTLP 70 KVGYNAVFGYYLEVTR.....PYY....EK....VPQE........YRPVQTLKD...RQRYTLP 71 KVGYNAVFGYYLEVTR.....PYY....EK....VPQE........YRPVQTLKD...RQRYTLP 72 KVGYNKAFGYYLSLPR.....SKS....EQ....APDN........YIRKQTLVN...EERYITP 73 KVGYNKAFGYYLSLPR.....SKS....EQ....APDN........YIRKQTLVN...EERYITP 74 KICFAQALGYYIEVSS.....EFA....PQ....LPKD........FIRRQSRLH...AERFTTI 75 KICFAQALGYYIEVSS.....EFA....PQ....LPKD........FIRRQSRLH...AERFTTI 76 KVCYAQALGYYIEVAS.....NLA....PQ....LPKE........FIRRQSRLH...AERFTTQ 77 ----------------.....---....--....----........---------...------- 78 ----------------.....---....--....----........---------...------- 79 KVCYAQALGYYIEVAS.....SFA....PQ....LPKE........FIRRQSRLH...AERFTTQ 80 KVEFNRVHGFYIELSK.....TQA....EQ....APAD........YQRRQTLKN...AERFITP 81 KVEFNRVHGFYIELSK.....TQA....EQ....APAD........YQRRQTLKN...AERFITP 82 KIGFNAVHGYYIQISQ.....GQA....HK....APIH........YVRRQTLKN...AERYIIP 83 KVGFNAVHGYYIQISR.....GQS....HL....APIN........YMRRQTLKN...AERYIIP 84 KVGFNAVHGYYIQISR.....GQS....HL....APIN........YMRRQTLKN...AERYIIP 85 KVGFNAVHGYYIQISR.....GQS....HL....APIN........YMRRQTLKN...AERYIIP 86 KVGYNAVHGYYIQISR.....GQS....HL....APIN........YVRRQTLKN...AERYIIP 87 KVGYNAVHGYYIQISR.....GQS....HL....APIN........YVRRQTLKN...AERYIIP 88 KVGYNRIHGYYIELPR.....VQA....EQ....APAD........YIRRQTLKG...AERFITP 89 KVGYNRIHGYFIELPR.....VQA....EQ....APAD........YIRRQTLKG...AERFITP 90 KVGYNRIHGYFIELPR.....VQA....EQ....APAD........YIRRQTLKG...AERFITP 91 KVGYNRVHGYFIELPT.....KQA....EQ....APGD........YIRRQTLKG...AERFITP 92 ----------------.....---....--....----........---------...------- 93 ----------------.....---....--....----........---------...------- 94 ----------------.....---....--....----........---------...------- 95 ----------------.....---....--....----........---------...------- 96 ----------------.....---....--....----........---------...------- 97 ----------------.....---....--....----........---------...------- 98 ----------------.....---....--....----........---------...------- 99 ----NKVFGYFIEITR.....ANL....QN....FEPSefg.....YMRKQTLSN...AERFITD 100 ----------------.....---....--....----........---------...------- 101 KIKHNNVLGYFIEVTA.....GNA....GS....MTDTdagrar..FIHRQTMAN...AMRFTTT 102 KVGYNRVHGYYIEISK.....GQA....DK....APVH........YTRRQTLTN...AERYITE 103 ----------------.....---....--....----........---------...------- 104 ----------------.....---....--....----........---------...------- 105 ----------------.....---....--....----........---------...------- 106 KVGFNKVFGYYIEVTK.....ANL....HL....LEEGr.......YERNETLTN...AERYITP 107 KVGFNKVFGYYIEVTK.....ANL....HL....LEEGr.......YERNETLTN...AERYITP 108 KIDYNKKDGYYFHVTN.....SQL....GN....VPAH........FFRKATLKN...SERFGTE 109 KIGYNKVMGYYIEVTK.....ANV....KY....VPEH........FRRRQTLSN...AERYTTE 110 KIGYNKVMGYYIEVTK.....PNL....KY....VPSY........FRRRQTLSN...SERFTTE 111 RVGYNQVFGYYIEVTK.....ANL....DK....IPDD........YERKQTLVN...SERFITP 112 RVGYNQVFGYYIEVTK.....ANL....DK....IPDD........YERKQTLVN...SERFITP 113 KISHNNVLGFFIDITP.....KNV....NKi...LDPK........FIHRQTTIN...SVRYTTY 114 KLENHHLHGWCMRLTR.....NDA....KE....LRKHkk......YIELSTVKA...GIFFSTK 115 KLENHHLHGWCMRLTR.....NDA....KE....LRKHkk......YIELSTVKA...GIFFSTK 116 KLESNSQIGHYFRVTC.....KEE....KA....LRNNkk......FTTIDIQKN...GVRFTNS 117 KLDSSAQFGYYFRVTC.....KEE....KV....LRNNkn......FSTVDIQKN...GVKFTNS 118 KLDSSAQFGYYFRVTC.....KEE....KV....LRNNkn......FSTVDIQKN...GVKFTNS 119 KLDSSAQFGYYFRVTC.....KEE....KV....LRNNkn......FSTVDIQKN...GVKFTNS 120 ----------------.....---....--....----........---------...------- 121 KLDSSAQFGYYFRVTC.....KEE....KV....LRNNkn......FSTVDIQKN...GVKFTNS 122 KLDSSAQFGYYFRVTC.....K--....--....----........---------...------- 123 KLDSSAQFGYYFRVTC.....KEE....KV....LRNNkn......FSTVDIQKN...GVKFTNS 124 KLDSSAQFGYYFRVTC.....KEE....KV....LRNNkn......FSTVDIQKN...GVKFTNS 125 ----------------.....---....--....----........---------...------- 126 ----------------.....---....--....----........---------...------- 127 FLENHKVHGWCMRLTR.....TEA....GC....IRNNsr......YLECSTQKN...GVYFTTK 128 ----------------.....---....--....---H........YTELSTQKN...GVYFTTK 129 HLEQHHLYGWCLRLTR.....TEA....GC....LRGRssh.....YTELSTQKN...GVYFTTK 130 HLEQHHLYGWCLRLTR.....TEA....GC....LRGRssh.....YTELSTQKN...GVYFTTK 131 LKLEKGSLGHVFRMSK.....KEE....QK....VRKKltgs....YLIIETRKD...GVKFTNS 132 ----------------.....---....--....----........---------...------- 133 KLDKAAQFGHVFRITK.....KEE....PK....IRKKlttq....FIVLETRKD...GVKFTNT 134 KLDKAAQFGHVFRITK.....KEE....PK....IRKKlttq....FIVLETRKD...GVKFTNT 135 KLESVAKLGHHFRITV.....KDD....SV....LRKNkn......YRIVDVIKG...GVRFTSD 136 KLESVAKLGHHFRITV.....KDD....SV....LRKNkn......YRIVDVIKG...GVRFTSD 137 KLESVAKLGHHFRITV.....KDD....SV....LRKNkn......YRIVDVIKG...GVRFTSD 138 ACVYIPLVGFVLSVPR.....DYG....VE....SQPD........MTLLYSTHE...DLRVRNA 139 ACVYIPLVGFVLSVPR.....DYG....VE....SQPD........MTLLYSTHE...DLRVRNA 140 ACVYIPLVGFVLSVPR.....DYG....VE....SQPD........MTLLYSTHE...DLRVRNA 141 ----------------.....---....--....----........-------ED...KLHYRSA 142 SVIYIPLIGFLLSIPRlpfmvEAS....DF....EIEG........LDFMFLSED...KLHYRSA 143 SVIYIPLIGFLLSIPRlpfmvEAS....DF....EIEG........LDFMFLSED...KLHYRSA 144 SVIYIPLIGFLLSIPRlpsmvEAS....DF....EING........LDFMFLSEE...KLHYRSA 145 SVIYIPLIGFLLSIPRlpsmvEAS....DF....EING........LDFMFLSEE...KLHYRSA 146 ----------------.....---....--....----........---------...---YRSA 147 SVIYIPLIGFLLSIPRlpsmvEAS....DF....EING........LDFMFLSEE...KLHYRSA 148 NAVYIPQLGYLVTISV.....LME....PL....LDGIpnlq....WEEIFRSSE...NIYFKNG 149 NAVYIPQLGYLVTISV.....LME....PL....LDGIpnlq....WEEIFRSSE...NIYFKNG 150 KAEYFNKEGYAFSISS.....KKL....TK....LEHYmmn10nnsIIVLGKRGS...HHIITSP 151 KAEYFNKEGYAFSISS.....KKL....TK....LEHYmmn10nnsIIVLGKRGS...HHIITSP 0 490 500 510 520 530 540 | | | | | | | 1 ELSDINDEFLEFHLKYTRAEEEVI.SMLCKKAEEFIP.LIPAMAQLIATLDVFVSLSTFA..ATS 2 KLISLEVDINNAEDNVVAFEQEIF.DEIASNVVMHNK.VLKKVAEFFAYIDLVVNFGYLA..KKN 3 IWTDLGHELELLNLKIRNEEANII.DLFKRKFIDRSN.VVRQVATTLGYLDTLSSFAVLA..NER 4 IWTDLGHELELLNLKIRNEEANII.DLFKRKFIDRSN.EVRQVATTLGYLDTLSSFAVLA..NER 5 GWTSLGMDLENTKLHIHQEEQRVL.KSITDEIVSHHK.TLRSLANALDELDISTSLATLA..QEQ 6 GWTSLGMDLENTKLHIHQEEQRVL.KSITDEIVSHHK.TLRSLANALDELDISTSLATLA..QEQ 7 GWTSLGMDLENTKLHIHQEEQRVL.KSITDEIVSHHK.TLRSLANALDELDISTSLATLA..QEQ 8 ------------AASRNLREFEVK.VDAATRLGELRG.AVEGEIRDIMEFDYRLALGLFA..HEY 9 ----------SVERELKIELYMRA.REIVPRIIPYIQ.GLKEEIERAYELEFILALKRFS..R-- 10 ----------SVERELKLELYLKS.REVLEDILPYLP.KLKEEIEKAYELEFIIALKRFS..K-- 11 EAVELNNMEVRHANSEKAEEMAIL.SILTSEVVMAQR.EILHLLDRILELDIAFARASHA..NWI 12 AVTQLNNELTRLILDEEAEVRRIL.TELSALLAQD-S.AVPMTLATIGELDLIASKAKLA..RDW 13 AAVSMNDDLQSARASVAKAEAEIL.SMLTEKIN----.----------------ARATYS..RAY 14 AIVELGNKLRQARRQEQTEEERIL.RQLSDQVLEVLL.DLEHLLAIATRLDLATARVRYS..FWL 15 AIVDMNNSLQQAKVKEKQEIERIL.RVLTEKTAEYTE.ELFLDLQVLQTLDFIFAKARYA..KAV 16 SVVEMNNQISRLRHDEAIEKERIL.TQLTGYVAADKD.ALLVAEQVMGQLDFLIAKARYS..RSI 17 EFVELNNRVRLLEEEERLEISRIL.RQLTNILLSRLN.DLERNVELIARFDSLYARVKFA..REF 18 FVIHLNNKLTELKQKEEEEVRKVL.QRITEYIGDYAK.ELLESFEACVEVDFQQCKYRFS..KLV 19 DIVNANNRLNYLSLEKERIILKIL.RNLSAKVHSNIV.LLDNLYNNFLYYDSLKARAIYG..IKT 20 SAQKIAQKIAQIGNEIDCCIVEMC.QTLSHSLQKHLL.FLKFLFKEFDFLDSLQARLNFA..KAY 21 SAQKIAQKIAQIGNEIDCCIVEMC.QTLSRSLQKHLL.FLKFLFKEFDFLDSLQARLNFA..KAY 22 SVENLQNDIEKIKNQKEEIYYEYA.KNFSAFLAKNLP.FLKFINTAFDLFDHYSARVLLA..KKR 23 SVENLQNDIEKIKIKKKKFIMKYA.KNFSAFLAKNLP.FLKFINTAFDLFDHYSARVLLAkkKDF 24 NIIKKNARLKEVMEEILLLSEETV.DELLDKIATHIS.ELFMIAEAVAILDLVCSFTYNL..KEN 25 NIIKKNARLKEVMEEILLLSEETV.DELLDKIATHIS.ELFMIAEAVAILDLVCSFTYNL..KEN 26 ELMKQSSRYNDIVSEITTLNSTII.HDMYTSINSYTP.ILLMVSEAIGTLDLLCSFAYFT..SLQ 27 DLIKMNERCQESLREIYHMTYMIV.CKLLSEIYEHIH.CLYKLSDTVSMLDMLLSFAHAC..TLS 28 DLIKMNERCQESLREIYHMTYMIV.CKLLSEIYEHIH.CLYKLSDTVSMLDMLLSFAHAC..TLS 29 KVIAYNDRLEQVVAEMFLASDVIV.CDMIEEMQPMIP.VLYYAMDALSSIDFLCGLATYS..DLR 30 RTQKLTQKLEYYKDLLIRESELQY.KEFLNKITAEYT.ELRKITLNLAQYDCILSLAATS..CNV 31 RTQKLTQKLEYYKDLLIRESELQY.KEFLNKITAEYT.ELRKITLNLAQYDCILSLAATS..CNV 32 EIVAGLDELALATEHLAIVNRASW.DSFLKSFSRYYT.DFKAAVQALAALDCLHSLSTLS..RNK 33 EIVAGLDELALATEHLAIVNRASW.DSFLKSFSRYYT.DFKAAVQALAALDCLHSLSTLS..RNK 34 EIVAGLDELALATEHLAIVNRASW.DSFLKSFSRYYT.DFKAAVQALAALDCLHSLSTLS..RNK 35 FIVESYRRLNQLREQLVLDCNAEW.LGFLENFGEHYH.TLCKAVDHLATVDCIFSLAKVA..KQG 36 ------------------------.------------.----------------------..--- 37 FIVESYRRLNQLREQLVLDCNAEW.LGFLENFGEHYH.TLCKAVDHLATVDCIFSLAKVA..KQG 38 FIVESYRRLNQLREQLVLDCNAEW.LGFLENFGEHYH.TLCKAVDHLATVDCIFSLAKVA..KQG 39 FIVESYRRLNQLREQLVLDCNAEW.LGFLENFGEHYH.TLCKAVDHLATVDCIFSLAKVA..KQG 40 FIVENYRHLNQLREQLVLDCSAEW.LDFLEKFSEHYH.SLCKAVHHLATVDCIFSLAKVA..KQG 41 FIVENYRHLNQLREQLVLDCSAEW.LDFLEKFSEHYH.SLCKAVHHLATVDCIFSLAKVA..KQG 42 KIQSLLIELSSHEENLTISSEKIY.RSFLSRISEHYN.ELRNVTTVLGTLDCLISFARIS..SQS 43 KIQSLLIELSSHEENLTISSEKIY.RSFLSRISEHYN.ELRNVTTVLGTLDCLISFARIS..SQS 44 DSEQLVAALDAVEKEKSKLGDDAT.RRVFEQFGHKNP.IWLETVKLVSSFDVLTSLALFAksSPF 45 ETRALLKDMQHAEDTRNMVLKDLA.RRLFEKFSNHYD.QWKQCIDCVANLDVLGSLAEYA..GQQ 46 TIEKKLANLINAEERRDVSLKDCM.RRLFYNFDKNYK.DWQSAVECIAVLDVLLCLANYS..RGG 47 TIEKKLANLINAEERRDVSLKDCM.RRLFYNFDKNYK.DWQSAVECIAVL----------..--- 48 TIEKKLANLINAEERRDVSLKDCM.RRLFYNFDKNYK.DWQSAVECIAVLDVLLCLANYS..RGG 49 TIEKKLANLINAEERRDVSLKDCM.RRLFYNFDKNYK.DWQSAVECIAVLDVLLCLANYS..RGG 50 TIEKKLANLINAEERRDVSLKDCM.RRLFYNFDKNYK.DWQSAVECIAVLDVLLCLANYS..RGG 51 TIEKKLANLINAEERRDTSLKDCM.RRLFCNFDKNHK.DWQSAVECIAVLDVLLCLANYS..QGG 52 TIEKKLANLINAEERRDTSLKDCM.RRLFCNFDKNHK.DWQSAVECIAVLDVLLCLANYS..QGG 53 -------------SDVNANGANDL.AALMDVFIGKAS.EWSLVINAVSTIDVLRSFAAMTl.SSF 54 -------------SDVNANGANDL.AALMDVFIGKAS.EWSLVINAVSTIDVLRSFAAMTl.SSF 55 ------------------------.------------.----------------------..--- 56 --------------DVTDENAETL.TILIELFIERAT.QWSEVIHTISCLDVLRSFAIAAslSAG 57 ------------------------.------------.----------------------..--- 58 ------------------------.------------.----------------------..--- 59 ELKELILELSKAESEKESKLKAIL.QNLIQLFVEHHT.EWRQLVSVVAELDVLTSLAIASgyFEG 60 TIKKLLKELSQAKSEKESALKSIS.QRLIGRFCEHQE.KWRQLVSATAELDVLISLAFAS..DSY 61 TIKKLLKELSQAKSEKESALKSIS.QRLIGRFCEHQE.KWRQLVSATAELDVLISLAFAS..DSY 62 ELRKKIKKLLEAEELHLAIMSRMQ.EKFYIRFDSNYE.QWLALIKYTASIDCFFSLSQAA..AAL 63 EVRALARSMAEAKEIHKTLEEDLK.NRLCQKFDAHYNtIWMPTIQAISNIDCLLAITRTS..EYL 64 EVRALARSMAEAKEIHKTLEEDLK.NRLCQKFDAHYNtIWMPTIQAISNIDCLLAITRTS..EYL 65 QLSELEAKLARAREGLVSFEQELF.ADIRRTVCSHTQ.LLRTNAARVAQLDVLQSFAHAA..LQH 66 EMKEKEREVYRLEALIRRREEEVF.LEVRERAKRQAE.ALREAARILAELDVYAALAEVA..VRY 67 EMKEKEREVYRLEALIRRREEEVF.LEVRERAKRQAE.ALREAARILAELDVYAALAEVA..VRY 68 EMKERERELYRLEALIKRREEEVF.LALRERARKEAE.ALREAARILAELDVYAALAEVA..VRH 69 EMKERERELYRLEALIKRREEEVF.LALRERARKEAE.ALREAARILAELDVYAALAEVA..VRH 70 EMKERERELYRLEALIKRREEEVF.LALRERARKEAE.ALREAARILAELDVYAALAEVA..VRH 71 EMKERERELYRLEALIKRREEEVF.IALRERARKEGE.ALREAARILAELDVYAALAEVA..VRH 72 ELKERETRILTAQADLNQLEYEIF.TEVRATVAEKAQ.PIRDVAKAVAAIDVLAGLAEVA..VYQ 73 ELKERETRILTAQADLNQLEYEIF.TEVRATVAEKAQ.PIRDVAKAVAAIDVLAGLAEVA..VYQ 74 ELQQFQDDMSNISEKLQTLETQFF.KDLCSHILQLRT.EILALSQSLADLDYIISLADLA..HAQ 75 ELQQFQDDMSNISEKLQTLETQFF.KDLCSHILQLRT.EILALSQSLADLDYIISLADLA..HAQ 76 ELQQFQDEVFSVEDKLQTLETKLF.KELCFYIVEHRD.LILKLSTAVADLDYVVSLAELA..AEY 77 ------------------------.------------.----------------------..--- 78 ------------------------.------------.----------------------..--- 79 ELQQFQDEVFSVEDKLQTLETKLF.KELCCYILQHRD.LILELSTTIADLDYVISLAELA..AEY 80 ELKAFEDKVLTAQEQALALEKQLF.DGVLKNLQTALP.QLQKAAKAAAALDVLSTFSALA..KER 81 ELKAFEDKVLTAQEQALALEKQLF.DGVLKNLQTALP.QLQKAAKAAAALDVLSTFSALA..KER 82 ELKEYEDKVLKSKGAALALEKQLY.DELFDLLLPHLG.SLQLASLALSELDVLVNLAERA..DTL 83 ELKEYEDKVLTSKGKALALEKQLY.EELFDLLLPHLE.ALQQSASALAELDVLVNLAERA..YTL 84 ELKEYEDKVLTSKGKALALEKQLY.EELFDLLLPHLE.ALQQSASALAELDVLVNLAERA..YTL 85 ELKEYEDKVLTSKGKALALEKQLY.EELFDLLLPHLE.ALQQSASALAELDVLVNLAERA..YTL 86 ELKEYEDKVLTSKGKALALEKQLY.DELFDLLLPHLA.DLQQSANALAELDVLVNLAERA..WTL 87 ELKEYEDKVLTSKGKALALEKQLY.DELFDLLLPHLA.DLQQSANALAELDVLVNLAERA..WTL 88 ELKAFEDKALSAKSRALAREKALY.EELLEILIAQLA.PLQETATALAELDVLANLAERA..LNL 89 ELKAFEDKALSAQSRALAREKALY.EELLERLIGHLA.PLQDSASALAELDVLANLAERA..LNL 90 ELKAFEDKALSAQSRALAREKALY.EELLERLIGHLA.PLQDSASALAELDVLANLAERA..LNL 91 ELKAFEDKALSAKSRALAREKMLY.DALLETLISHLA.PLQDSAAALAELDVLINLAERA..LNL 92 ------------------------.------------.----------------------..--- 93 ------------------------.------------.----------------------..--- 94 ------------------------.------------.----------------------..--- 95 ------------------------.------------.----------------------..--- 96 ------------------------.------------.----------------------..--- 97 ------------------------.------------.----------------------..--- 98 ------------------------.------------.----------------------..--- 99 ELKEKEDIILGAEDKAIELEYQLF.VQLREEVKKYTE.RLQQQAKIISELDCLQSFAEIA..QKY 100 ---------------------ETF.EAMVREVVAEAE.AIKAAALALATIDVSAGLAVLA..EEQ 101 ELAELETKIANAADRALAIELETF.EAMVREVVAEAE.AIKAAALALATIDVSAGLAVLA..EEQ 102 ELKAFEDKVLSARDRALVREKLLY.EQLLDTVGAQLE.PLKRCAAALSELDVLVCFAERA..QTL 103 ------------------------.------------.----------------------..--- 104 ------------------------.------------.----------------------..--- 105 ------------------------.------------.----------------------..--- 106 ELKEKEALILEAENNICELEYELF.TELREKVKQYIP.RLQQLAKQMSELDALQCFATIS..ENR 107 ELKEKEALILEAENNICELEYELF.TELREKVKQYIP.RLQQLAKQMSELDALQCFATIS..ENR 108 ELARIEGDMLEAREKSANLEYEIF.MRIREEVGKYIQ.RLQALAQGIATVDVLQSLAVVA..ETQ 109 ELQRLEEKILSAQTRINELEYELY.RELREEVVKELD.KVGNNATLIGEVDYIQSLAWLA..LEK 110 ELQRLEEKILSAQTRINDLEYELY.KELRERVVKELD.KVGNNASAVAEVDFIQSLAQIA..YEK 111 ELKEFETKIMAAKERIEELEKELF.KSVCEEVKKHKE.VLLEISEDLAKIDALSTLAYDA..IMY 112 ELKEFETKIMAAKERIEELEKELF.TSVCEEVKKHKE.VLLEISEDLAKIDALSTLAYDA..IMY 113 ELQNLENELVNAQTLVIRLEKELY.TDICRKVIEKSS.YLKILANSLSGLDVFCNFAYIA..DEY 114 QLKSIANETNILQKEYDKQQSALV.REIINITLTYTP.VFEKLSLVLAHLDVIASFAHTSsyAPI 115 QLKSIANETNILQKEYDKQQSALV.REIINITLTYTP.VFEKLSLVLAHLDVIASFAHTSsyAPI 116 KLSSLSEEYMRNREEYEEAQNAIV.KEIITISAGYVD.PIQTLNDVIAQLDAVVSFAHVSnsAPV 117 ELSSLNEEYTKNKGEYEEAQDAIV.KEIVNISSGYVE.PMQTVNDVLAHLDAVVSFAHVSnaAPV 118 ELSSLNEEYTKNKGEYEEAQDAIV.KEIVNISSGYVE.PMQTLNDVLAHLDAIVSFAHVSnaAPV 119 ELSSLNEEYTKNKGEYEEAQDAIV.KEIVNISSGYVE.PMQTLNDVLAHLDAIVSFAHVSnaAPV 120 ------------------------.------------.----------------------..--- 121 KLTSLNEEYTKNKTEYEEAQDAIV.KEIVNISSGYVE.PMQTLNDVLAQLDAVVSFAHVSngAPV 122 ------------------------.------------.----------------------..--- 123 KLTSLNEEYTKNKTEYEEAQDAIV.KEIVNISSGYVE.PMQTLNDVLAQLDAVVSFAHVSngAPV 124 KLTSLNEEYTKNKTEYEEAQDAIV.KEIVNISSGYVE.PMQTLNDVLAQLDAVVSFAHVSngAPV 125 ------------------------.------------.----------------------..--- 126 ------------------------.------------.----------------------..--- 127 TLQALRREFDQLSQNYNRTQSSLV.NEVVGVAASYCP.VLERLAAVLAHLDVIVSFAHCSvhAPI 128 RLHSLNNSYMDHQKSYRYHQNGLA.REVIKIAATYGP.PLEAIGQVIAHLDVILSFAHAStvAVI 129 RLHSLNNSYMDHQKSYRYHQNGLA.REVIKIAATYGP.PLEAIGQVIAHLDVILSFAHAStvAVI 130 RLHSLNNS----------------.------------.----------------------..--- 131 KLKNLSDQYQALFGEYTSCQKKVV.GDVVRVSGTFSE.VFENFAAVLSELDVLQSFADLAtsCPV 132 ------------------------.------------.----------------------..--- 133 KLKKLGDQYQSVVDDYRSCQKELV.DRVVETVTSFSE.VFEDLAGLLSEMDVLLSFADLAasCPT 134 KLKKLGDQYQSVVDDYRSCQKELV.DRVVETVTSFSE.VFEDLAGLLSEMDVLLSFADLAasCPT 135 KLEGYADEFASCRTRYEEQQLSIV.EEIIHVAVGYAA.PLTLLNNELAQLDCLVSFAIAArsAPT 136 KLEGYADEFASCRTRYEEQQLSIV.EEIIHVAVGYAA.PLTLLNNELAQLDCLVSFAIAArsAPT 137 KLEGYADEFASCRTRYEEQQLSIV.EEIIHVAVGYAA.PLTLLNNELAQLDCLVSFAIAArsAPT 138 TTSRLDDEFGDILMRLIDSQTAII.LTLKTRVMKKKR.SIIKLLSIASRIDVLISFGLIA..AQN 139 TTSRLDDEFGDILMRLIDSQTAII.LTLKTRVMKKKR.SIIKLLSIASRIDVLISFGLIA..AQN 140 TTSRLDDEFGDILMRLIDSQTAII.LTLKTRVMKKKR.SIIKLLSIASRIDVLISFGLIA..AQN 141 RTKELDTLLGDLHCEIRDQETLLM.YQLQCQVLARAS.VLTRVLDLASRLDVLLALASAA..RDY 142 RTKELDTLLGDLHCEIRDQETLLM.YQLQCQVLARAS.VLTRVLDLASRLDVLLALASAA..RDY 143 RTKELDTLLGDLHCEIRDQETLLM.YQLQCQVLARAS.VLTRVLDLASRLDVLLALASAA..RDY 144 RTKELDALLGDLHCEIRDQETLLM.YQLQCQVLARAA.VLTRVLDLASRLDVLLALASAA..RDY 145 RTKELDALLGDLHCEIRDQETLLM.YQLQCQVLARAA.VLTRVLDLASRLDVLLALASAA..RDY 146 RTKELDALLGDLHCEIRDQETLLM.YQLQCQVLARAA.VLTRVLDLASRLDVLLALASAA..RDY 147 RTKELDALLGDLHCEIRDQETLLM.YQLQCQVLARAA.VLTRVLDLASRLDVLLALASAA..RDY 148 RVLELDETYGDIYGAISDFEIEIL.FSLQEQILRRKT.QLTAYNILLSELEILLSFAQVS..AER 149 RVLELDETYGDIYGAISDFEIEIL.FSLQEQILRRKT.QLTAYNILLSELEILLSFAQVS..AER 150 TIHKVSIELNELEEQINIYVKQTYhQELKRLYFSYSE.LFLPLVNMISRLDVALSGAITA..IKF 151 TIHKVSIELNELEEQINIYVKQTYhQELKRLYFSYSE.LFLPLVNMISRLDVALSGAITA..IKF 550 560 570 | | | 1 SgiYTRPNLL........PLgskr....LELKQCRHPVIEGNse......K........PFIPND 2 E..YKRPVLT........SGke......ILLEKSRHPVVEHYtknt....E........IFTENF 3 N..LVCPKVD........ESnk......LEVVNGRHLMVEEGlsarsl..E........TFTANN 4 N..LVCPKVD........ESnk......LEVVNGRHLMVEEGlsarsl..E........TFTANN 5 D..FVRPVVD........DSha......HTVIQGRHPIVEKGlshkl...I........PFTPND 6 D..FVRPVVD........DSha......HTVIQGRHPIVEKGlshkl...I........PFTPND 7 D..FVRPVVD........DSha......HTVIQGRHPIVEKGlshkl...I........PFTPND 8 E..LTEPEFG........DE........ISLRGALHLNLVGS........R........KPQRVD 9 G..FTFPKIE........EGg.......IGFIKGRNLFI---........E........NPQPVS 10 G..FTFPKIE........EGg.......IGFVKGKNLFI---........E........NPQPVS 11 N..GVYPNVT........SEhtktpglaVDIDSAQHPLLLGSvlg9nggdI........FPVPVD 12 R..LNRPEAA........PDgl......YDLHEARHPLI---........E........NPVAND 13 G..GAHPDIYlpp24pse--kpl9kewlLYLPRCYHPLLLYQhkkgi...-rkt20sgaPPIPAD 14 G..AHPPQWL........TPgdekp...ITLRQLRHPLLHWQaekegg..P........AVVPIT 15 K..ATKPIMN........DTgf......IRLKKARHPLLPP-........D........QVVAND 16 K..GTKPIFK........EErt......VYLPKAYHPLLNR-........E........TVVANT 17 N..GTVVKPS........SR........IRLVNARHPLIPK-........E........RVVPIN 18 E..GSFPDFG........EW........VELYEARHPVLVLVk.......E........DVVPVG 19 K..GVFPEIS........NV........LNIFDAHHPLL---........K........DSKAIT 20 NleFVMPSFT........QKk.......MILENFSHPIL---........K........EPKPLN 21 NleFVMPSFT........QKk.......MILENFSHPIL---........K........EPKPLN 22 DfeFVLCDQS........TD........LVLKNFAHPAL---........K........NPKSVS 23 E..FVLCDQS........TD........LVLKNFAHPAL---........K........NPKSVS 24 N..YTIPIFT........NN........LLIRDSRHPLLEKVl.......K........NFVPNT 25 N..YTIPIFT........NN........LLIRDSRHPLLEKVl.......K........NFVPNT 26 KdsYTCPEFA........KE........VTIMRSLHPILGGNn.......S........NFVANN 27 D..YVRPEFT........DT........LAIKQGWHPILEKIsa......E........KPIANN 28 D..YVRPEFT........DT........LAIKQGWHPILEKIsa......E........KPIANN 29 D..TCKPTFG........PS........FSISQGRHPILDWDds......E........KTITND 30 N..YVRPTFV........NGqqa.....IIAKNARNPIIESLd.......V........HYVPND 31 N..YVRPTFV........NGqqa.....IIAKNARNPIIESLd.......V........HYVPND 32 N..YVRPEFV........DDcepve...INIQSGRHPVLETIlq......D........NFVPND 33 N..YVRPEFV........DDcepve...INIQSGRHPVLETIlq......D........NFVPND 34 N..YVRPEFV........DDcepve...INIQSGRHPVLETIlq......D........NFVPND 35 N..YCRPTLQ........EEkk......IIIKNGRHPMIDVLlgeq....D........QFVPNS 36 -..-------........--........--------------........-........------ 37 N..YCRPTLQ........EEkk......IIIKNGRHPMIDVLlgeq....D........QFVPNS 38 N..YCRPTLQ........EEkk......IIIKNGRHPMIDVLlgeq....D........QFVPNS 39 N..YCRPTLQ........EEkk......IIIKNGRHPMIDVLlgeq....D........QFVPNS 40 D..YCRPTVQ........EErk......IVIKNGRHPVIDVLlgeq....D........QYVPNN 41 D..YCRPTVQ........EErk......IVIKNGRHPVIDVLlgeq....D........QYVPNN 42 G..YTRPEFS........DKe.......LLIHESRHPMIELLsd......K........SFVPNH 43 G..YTRPEFS........DKe.......LLIHESRHPMIELLsd......K........SFVPNH 44 E..MCMPEFD........FNatdpy...LIVDKGVHPCLALQsrnevtqtT........SFIANS 45 Mv.ICVPELV........SDadqpf...IQLEEGYHPCANA-........S........TYIPNG 46 DgpMCRPVILlp......--edtppf..LELKGSRHPCITKTffg.....D........DFIPND 47 -..-------........--........--------------........-........------ 48 DgpMCRPVILlp......--edtppf..LELKGSRHPCITKTffg.....D........DFIPND 49 DgpMCRPVILlp......--edtppf..LELKGSRHPCITKTffg.....D........DFIPND 50 DgpMCRPVILlp......--edtppf..LELKGSRHPCITKTffg.....D........DFIPND 51 DgpMCRPEIVlpg.....--edthpf..LEFKGSRHPCITKTffg.....D........DFIPND 52 DgpMCRPEIVlpg.....--edthpf..LEFKGSRHPCITKTffg.....D........DFIPND 53 Ga.MCRPQVL........LKddvpv...LRMKGLWHPYAFAGna......N........SLVPND 54 Ga.MCRPQVL........LKddvpv...LRMKGLWHPYAFAGna......N........SLVPND 55 -..-------........--........--------------........-........------ 56 S..MARPVIF........PEsea14gpiLKIQGLWHPFAVAAdg......Q........LPVPND 57 -..-------........--........--------------........-........------ 58 -..-------........--........--------------........-........------ 59 P..SCCPTIK........ESngtddtptFHARNLGHPILRSDslgk....G........SFVPND 60 EgvRCRPVIS........GStsdgvph.LSATGLGHPVLRGDslgr....G........SFVPNN 61 EgvRCRPVIS........GStsdgvph.LSATGLGHPVLRGDslgr....G........SFVPNN 62 GepYCRPEII........EQkdgh....LYFEELRHPCINASaa......S........TFVPND 63 GapSCRPTIV........DEvds12ngfLKFKSLRHPCFNLGatta....K........DFIPND 64 GapSCRPTIV........DEvds12ngfLKFKSLRHPCFNLGatta....K........DFIPND 65 G..WSQPVFI........KDga......LRITGGRHPVVELHlps.....G........EFVPND 66 G..YVRPRFG........DR........LQIRAGRHPVVERR........T........EFVPND 67 G..YVRPRFG........DR........LQIRAGRHPVVERR........T........EFVPND 68 G..YTRPRFG........ER........LRIRAGRHPVVERR........T........AFVPND 69 G..YTRPRFG........ER........LRIRAGRHPVVERR........T........AFVPND 70 G..YTRPRFG........ER........LRIRAGRHPVVERR........T........AFVPND 71 G..YTRPRFG........ER........LRIRAGRHPVVRRR........T........AFVPND 72 G..YCRPIMQ........MEpgl.....IDIEAGRHPVVEQSlga.....G........FFVAND 73 G..YCRPIMQ........MEpgl.....IDIEAGRHPVVEQSlga.....G........FFVAND 74 G..YCRPHVD........MSdt......LCIYRGCHPVAKTLvdt.....G........KFIPND 75 G..YCRPRVD........MSdt......LCIYRGCHPVAKTLvdt.....G........KFIPND 76 D..YRRPLVD........HSda......LSITKGMHPVALTLldk.....G........TFIPND 77 -..-------........--........--------------........-........------ 78 -..-------........--........--------------........-........------ 79 D..YRRPLVD........HSda......LSITKGMHPVALTLldr.....G........TFIPND 80 N..FVRPEFA........DYpa......IHIENGRHPVVEQQv.......R........HFTANH 81 N..FVRPEFA........DYpv......IHIENGRHPVVEQQv.......R........HFTANH 82 N..YVMPTFC........DEvs......VKIKNGRHPVVEQVlk......D........PFIANP 83 N..YTCPTFI........DKpg......IRITEGRHPVVEQVln......E........PFIANP 84 N..YTCPTFI........DKpg......IRITEGRHPVVEQVln......E........PFIANP 85 N..YTCPTFI........DKpg......IRITEGRHPVVEQVln......E........PFIANP 86 N..YTCPTFT........DKpg......IRITEGRHPVVEQVln......E........PFIANP 87 N..YTCPTFT........DKpg......IRITEGRHPVVEQVln......E........PFIANP 88 D..FNRPRFV........EEpc......LRIRQGRHPVVEQVld......T........PFVAND 89 D..LNRPRFV........EHtc......LHIEQGRHPVVEQVle......T........PFVAND 90 D..LNRPRFV........EHtc......LHIEQGRHPVVEQVle......T........PFVAND 91 D..LNCPRFV........DEpc......LRIEQGRHPVVEQVlt......T........PFVAND 92 -..-------........--........--------------........-........------ 93 -..-------........--........--------------........-........------ 94 -..-------........--........--------------........-........------ 95 -..-------........--........--------------........-........------ 96 -..-------........--........--------------........-........------ 97 -..-------........--........--------------........-........------ 98 -..-------........--........--------------........-........------ 99 N..YTRPSFS........ENkt......LELVESRHPVVERVmdy.....N........DYVPNN 100 N..YTRPTVD........RSrm......FAIDGGRHPVVEQAlrrqaa..N........PFVANG 101 N..YTRPTVD........RSrm......FAIDGGRHPVVEQAlrrqaa..N........PFVANG 102 D..WVRPELE........HTsc......LHIEGGRHPVVEAVre......Q........RFEPND 103 -..-------........--........--------------........-........------ 104 -..-------........--........--------------........-........------ 105 -..-------........--........--------------........-........------ 106 H..YTKPEFS........KDe.......VEVIEGRHPVVEKVmds.....Q........EYVPNN 107 H..YTKPEFS........KDe.......VEVIEGRHPVVEKVmds.....Q........EYVPNN 108 H..LIRPEFG........DDsq......IDIRKGRHAVVEKVmga.....Q........TYIPNT 109 G..WVKPEVH........EGye......LIIEEGKHPVIEEFt.......K........NYVPND 110 D..WAKPQIH........EGye......LIIEEGRHPVIEEFv.......E........NYVPND 111 N..YTKPVFS........EDr.......LEIKGGRHPVVERFt.......Q........NFVEND 112 N..YTKPVFS........EDr.......LEIKGGRHPVVERFt.......Q........NFVEND 113 D..YTKPEFT........NDls......FDIVKGRHPVVEAAlrkts...K........SFVYND 114 P..YIRPKLH........PMdserr...THLISSRHPVLEMQdd......I........SFISND 115 P..YIRPKLH........PMdserr...THLISSRHPVLEMQdd......I........SFISND 116 P..YVRPVIL........EKgqgr....IVLHSARHPCIEMQdd......V........AFIPND 117 P..YVRPVIL........EKgkgr....IIVKASRHACVEVQhd......V........AFIPND 118 P..YVRPVIL........EKgkgr....IILKASRHACVEVQde......V........AFIPND 119 P..YVRPVIL........EKgkgr....IILKASRHACVEVQde......V........AFIPND 120 -..-------........--........--------------........-........------ 121 P..YVRPAIL........EKgqgr....IILKASRHACVEVQde......I........AFIPND 122 -..-------........--........--------------........-........------ 123 P..YVRPAIL........EKgqgr....IILKASRHACVEVQde......I........AFIPND 124 P..YVRPAIL........EKgqgr....IILKASRHACVEVQde......I........AFIPND 125 -..-------........--........--------------........-........------ 126 -..-------........--........--------------........-........------ 127 S..YVRPKIH........PRgtgr....TVLTEARHPCMEVQdd......V........TFITND 128 P..YVRPNIVdss24edt--pnf17carLYLKQARHPCLEAQdd......V........KFIPND 129 P..YVRPNIVdss24edt--pnf17carLYLKQARHPCLEAQdd......V........KFIPND 130 -..-------........--........--------------........-........------ 131 P..YVRPDIT........ASdegd....IVLLGSRHPCLEAQdg......V........NFIPND 132 -..-------........--........--------------........-........------ 133 P..YCRPEIT........SLdagd....IVLEGSRHPCVEAQdw......V........NFIPND 134 P..YCRPEIT........SSdagd....IVLEGSRHPCVEAQdw......V........NFIPND 135 P..YVRPKML........EEgare....LVLEDVRHPCLELQeh......V........NFIANS 136 P..YVRPKML........EEgare....LVLEDVRHPCLELQeh......V........NFIANS 137 P..YVRPKML........EEgare....LVLEDVRHPCLELQeh......V........NFIANS 138 G..WNCPALV........DEpv......IEAVELYHPISVLVvk......K........SFVPNQ 139 G..WNCPALV........DEpv......IEAVELYHPISVLVvk......K........SFVPNQ 140 G..WNCPALV........DEpv......IEAVELYHPISVLVvk......K........SFVPNQ 141 G..YSRPHYS........PCihg.....VRIRNGRHPLMELCa.......R........TFVPNS 142 G..YSRPHYS........PCihg.....VRIRNGRHPLMELCa.......R........TFVPNS 143 G..YSRPHYS........PCihg.....VRIRNGRHPLMELCa.......R........TFVPNS 144 G..YSRPRYS........PQvlg.....VRIQNGRHPLMELCa.......R........TFVPNS 145 G..YSRPRYS........PQvlg.....VRIQNGRHPLMELCa.......R........TFVPNS 146 G..YSRPRYS........PQvlg.....VRIQNGRHPLMELCa.......R........TFVPNS 147 G..YSRPRYS........PQvlg.....VRIQNGRHPLMELCa.......R........TFVPNS 148 N..YAEPQLV........EDeci.....LEIINGRHALYETFl.......D........NYIPNS 149 N..YAEPQLV........EDeci.....LEIINGRHALYETFl.......D........NYIPNS 150 N..YVEPCLTlakt....--qqtkgf..IEAANLRHPLVEQLntq.....E........ECIAHN 151 N..YVEPCLTlakt....--qqtkgf..IERANLRHPLVEQLntq.....E........ECIAHN 580 590 600 610 620 | | | | | 1 VVLDKCr.......LIILTGANMGGKSTYLRSAALSILLAQ..IGSFVPC.SSA.TISVVDGIFT 2 VRINKEky......FCLITGPNMAGKSTYLRQVALITLMAH..IGSFVPA.SKA.LIGITDKIFC 3 CELAKDn.......LWVITGPNMGGKSTFLRQNAIIVILAQ..IGCFVPC.SKA.RVGIVDKLFS 4 CELAKDn.......LWVITGPNMGGKSTFLRQNAIIVILAQ..IGCFVPC.SKA.RVGIVDKLFS 5 CFVGNGnvn.....IWLITGPNMAGKSTFLRQNAIISILAQ..IGSFVPA.SNA.RIGIVDQIFS 6 CFVGNGnvn.....IWLITGPNMAGKSTFLRQNAIISILAQ..IGSFVPA.SNA.RIGIVDQIFS 7 CFVGNGnvn.....IWLITGPNMAGKSTFLRQNAIISILAQ..IGSFVPA.SNA.RIGIVDQIFS 8 YRIGDPdn......VVLLTGANSGGKTTLLETLAQVTIMAQ..MGLPVCA.LEA.CVRVVDEVYF 9 YFVGSAkgq11essVVILTGANSGGKTSLLELMLQIVILAH..MGLPVPA.SEA.WVEPLDEVFF 10 YFVGKArep11gsrVVILTGANSGGKTSLLELMLQIVVLAH..MGLPVPA.ENA.WVDVLNEVFF 11 IKVESSak......VVVISGPNTGGKTALLKTLGLLSLMSK..SGMYLPA.KNCpRLPWFDLILA 12 IQLGETk.......LLLITGPNMGGKTATLKTLGLAVLMHQ..CGLYVAA.ASA.RLPVVRDILV 13 FQISKGtr......VLVITGPNTGGKTICLKSVGLAAMMAK..SGLYVLAtESA.RIPWFDNIYA 14 LTIDSQir......VIAITGPNTGGKTVTLKTLGLVALMAK..VGLYIPAkETV.EMPWFAQILA 15 IELGRDfs......TIVITGPNTGGKTVTLKTLGLLTLMAQ..SGLHIPAdEGS.EAAVFEHVFA 16 IEFMEDie......TVIITGPNTGGKTVTLKTLGLIIVMAQ..SGLLIPTlDGS.QLSVFKNVYC 17 LELPPNkr......GFIITGPNMGGKTVTVKTVGLFTALMM..SGFPLPCdEGT.ELKVFPKIMA 18 ILLKEKk.......GLILTGPNTGGKTVALKTLGLSVLMFQ..SAIPVPAsPNS.KLPLFEKVFT 19 FTPAENr.......VVIITGPNAGGKTVTLKTIGLLSAMFQ..FGIPIVVgESS.TFKIFDNIFI 20 LKFEKS........MLAVTGVNAGGKTMLLKSLLSAAFLSKhlIPMKINA.HHS.IIPYFKEIHA 21 LKFEKS........MLAVTGVNAGGKTMLLKSLLSAAFLSKhlIPMKINA.HHS.TIPYFREIHA 22 LEFKKQ........VLIITGVNAGGKSMLLKSMLSAAFLAKhlLPMHIKA.SES.KIGTFKEFDA 23 LEFKKQ........VLIITGVNAGGKSMLLKSMLSAAFLAKhlLPMHIKA.SES.KIGTFKEFDA 24 ISSTKHsss.....LQIITGCNMSGKSVYLKQVALICIMAQ..MGSGIPA.LYG.SFPVFKRLHA 25 ISSTKHsss.....LQIITGCNMSGKSVYLKQVALICIMAQ..MGSGIPA.LYG.SFPVFKRLHA 26 YSCNHElsr.....IHVITGANMSGKSVYLRQIAYLVIMAQ..MGCFVPA.EYA.RMRIFNSLYS 27 TYVTEGsn......FLIITGPNMSGKSTYLKQIALCQIMAQ..IGSYVPA.EYS.SFRIAKQIFT 28 TYVTEGsn......FLIITGPNMSGKSTYLKQIALCQIMAQ..IGSYVPA.EYS.SFRIAKQIFT 29 TCLTRDrr......FGIITGPNMAGKSTYLKQTAQLAIMAQ..IGCFIPA.NYA.SLPIFNRIFS 30 IMMSPEngk.....INIITGPNMGGKSSYIRQVALLTIMAQ..IGSFVPA.EEI.RLSIFENVLT 31 IMMSPEngk.....INIITGPNMGGKSSYIRQVALLTIMAQ..IGSFVPA.EEI.RLSIFENVLT 32 TILHAEgey.....CQIITGPNMGGKSCYIRQVALISIMAQ..VGSFVPA.SFA.KLHVLDGVFT 33 TILHAEgey.....CQIITGPNMGGKSCYIRQVALISIMAQ..VGSFVPA.SFA.KLHVLDGVFT 34 TILHAEgey.....CQIITGPNMGGKSCYIRQVALISIMAQ..VGSFVPA.SFA.KLHVLDGVFT 35 TSLSDSer......VMIITGPNMGGKSSYIKQVALVTIMAQ..IGSYVPA.EEA.TIGIVDGIFT 36 ------........---------------------------..-------.---.---------- 37 TSLSDSerg15wekLLHKTG------------LTLVTIMAQ..IGSYVPA.E-A.TIGIVDGIFT 38 TSLSDSer......VMIITGPNMGGKSSYIKQVTLVTIMAQ..IGSYVPA.EEA.TIGIVDGIFT 39 TSLSDSer......VMIITGPNMGGKSSYIKQVALVTIMAQ..IGSYVPA.EEA.TIGIVDGIFT 40 TDLSEDser.....VMIITGPNMGGKSSYIKQVALITIMAQ..IGSYVPA.EEA.TIGIVDGIFT 41 TDLSEDser.....VMIITGPNMGGKSSYIKQVALITIMAQ..IGSYVPA.EEA.TIGIVDGIFT 42 IHLSSDgvr.....CLLITGPNMGGKSSFVKQLALSAIMAQ..SGCFVPA.KSA.LLPIFDSILI 43 IHLSSDgvr.....CLLITGPNMGGKSSFVKQLALSAIMAQ..SGCFVPA.KSA.LLPIFDSILI 44 TTMGASeaa.....VMLLTGPNMGGKSTLMRQTAVLAILAH..IGSMVPA.FSM.RLTPIDRIFT 45 LELGTAseap....LSLLTGPNMGGKSTLMREVGLLVIMAQ..I------.---.---------- 46 ILIGCEeee10kayCVLVTGPNMGGKSTLMRQAGLLAVMAQ..MGCYVPA.EVC.RLTPIDRVFT 47 ------........---------------------------..-------.---.---------- 48 ILIGCEeee10kayCVLVTGPNMGGKSTLMRQAGLLAVMAQ..MGCYVPA.EVC.RLTPIDRVFT 49 ILIGCEeee10kayCVLVTGPNMGGKSTLMRQAGLLAVMAQ..MGCYVPA.EVC.RLTPIDRVFT 50 ILIGCEeee10kayCVLVTGPNMGGKSTLMRQAGLLAVMAQ..MGCYVPA.EVC.RLTPIDRVFT 51 ILIGCEeea10kayCVLVTGPNMGGKSTLIRQAGLLAVMAQ..LGCYVPA.EKC.RLTPVDRVFT 52 ILIGCEeea10kayCVLVTGPNMGGKSTLIRQAGLLAVMAQ..LGCYVPA.EKC.RLTPVDRVFT 53 LTLGQDlsglnrf.ALLLTGPNMGGKSTIMRATCLAVVLAQ..LGCYVPC.TSC.ELTLADSIFT 54 LTLGQDlsglnrf.ALLLTGPNMGGKSTIMRATCLAVVLAQ..LGCYVPC.TSC.ELTLADSIFT 55 ------........----TGPNMGGKSTLLRATCLAVIFAQ..LGCYVPC.ESC.EISLVDTIFT 56 ILLGEArrs10hprSLLLTGPNMGGKSTLLRATCLAVIFAQ..LGCYVPC.ESC.EISLVDTIFT 57 ------........---------------------------..-------.---.---------- 58 ------........------PNMGGKSTIMRATCLAIVLAQ..LGCYVPC.QSC.ELTLADAIFT 59 VKIGGPgnas....FIVLTGPNMGGKSTLLRQVCLTIILAQ..IGADVPA.EKL.ELSLVDRIFV 60 VKIGGAekas....FILLTGPNMGGKSTLLRQVCLAVILAQ..IGADVPA.ETF.EVSPVDKICV 61 VKIGGAekas....FILLTGPNMGGKSTLLRQVCLAVILAQ..IGADVPA.ETF.EVSPVDKICV 62 VVLGGEspn.....MIVLTGPNMAGKSTLLRQVCIAVIMAQ..LGCWVPA.KRA.SITPMTSIYT 63 IELGKEqpr.....LGLLTGANAAGKSTILRMACIAVIMAQ..MGCYVPC.ESA.VLTPIDRIMT 64 IELGKEqpr.....LGLLTGANAAGKSTILRMACIAVIMAQ..MGCYVPC.ESA.VLTPIDRIMT 65 LTLSSSehavlpr.FALITGPNMAGKSTFLRQTALICLIAQ..VGSFVPA.EKA.ELTPVDRIFC 66 LEMAHE........LVLITGPNMAGKSTFLRQTALIALLAQ..VGSFVPA.EEA.HLPLFDGIYT 67 LEMAHE........LVLITGPNMAGKSTFLRQTALIALLAQ..VGSFVPA.EEA.HLPLFDGIYT 68 LEMAHE........LVLVTGPNMAGKSTFLRQTALIALLAQ..IGSFVPA.EEA.ELPLFDGIYT 69 LEMAHE........LVLVTGPNMAGKSTFLRQTALIALLAQ..IGSFVPA.EEA.ELPLFDGIYT 70 LEMAHE........LVLVTGPNMAGKSTFLRQTALIALLAQ..IGSFVPA.EEA.ELPLFDGIYT 71 LEMAHE........LVRVTGPNMAGKSTFLRQTALIALLAQ..IGSFVPA.EEA.ELPLFDGIYT 72 TQLGHDhwhpd...LVILTGPNASGKSCYLRQVGLIQLMAQ..TGSFIPA.KTA.TLSICDRIFT 73 TQLGHDhwhpd...LVILTGPNASGKSCYLRQVGLIQLMAQ..TGSFIPA.KTA.TLSICDRIFT 74 TEMRGSqtr.....MILLTGPNMAGKSTYIRQIALLVIMAQ..MGSYIPA.KSA.HIGVIDKIFT 75 TEMRGSqtr.....MILLTGPNMAGKSTYIRQIALLVIMAQ..MGSYIPA.KSA.HIGVIDKIFT 76 TVMHSAqtr.....MILLTGPNMAGKSTYIRQIALLVIMAQ..MGSFIPA.RSA.HIGIVDKIFT 77 ------........---------AGKSTYIRQIALLVIMAQ..MGSFIPA.RSA.HIGIVDKIFT 78 ------........---------AGKSTYIRQIALLVIMAQ..MGSFIPA.RSA.HIGIIDKIFT 79 TIMHSAqtr.....MILLTGPNMAGKSTYIRQIALLVIMAQ..MGSFIPA.RSA.HIGIIDKIFT 80 TNLDHKhr......LMLLTGPNMGGKSTYMRQVALIVLLAH..TGCFVPA.DAA.TIGPIDQIFT 81 TDLDHKhr......LMLLTGPNMGGKSTYMRQVALIVLLAH..TGCFVPA.DAA.TIGPIDQIFT 82 VELNHNrh......LLVITGPNMGGKSTYMRQTALITLLAY..IGSFVPA.DSA.RIGPIDRIFT 83 LNLSPQrr......MLIITGPNMGGKSTYMRQTALIALMAY..IGSYVPA.QKV.EIGPIDRIFT 84 LNLSPQrr......MLIITGPNMGGKSTYMRQTALIALMAY..IGSYVPA.QKV.EIGPIDRIFT 85 LNLSPQrr......MLIITGPNMGGKSTYMRQTALIALMAY..IGSYVPA.QKV.EIGPIDRIFT 86 LNLSPQrr......MLIITGPNMGGKSTYMRQTALIALLAY..IGSYVPA.QNV.EIGPIDRIFT 87 LNLSPQrr......MLIITGPNMGGKSTYMRQTALIALLAY..IGSYVPA.QNV.EIGPIDRIFT 88 LELDDNtr......MLIITGPNMGGKSTYMRQTALIVLLAH..IGSFVPA.QSC.ELSLVDRIFT 89 LALDADtr......MLVITGPNMGGKSTYMRQTALIVLLAH..IGSFVPA.ARC.ELSLVDRIFT 90 LALDADtr......MLVITGPNMGGKSTYMRQTALIVLLAH..IGSFVPA.ARC.ELSLAVRIFT 91 LGLDNStr......MLIITGPNMGGKSTYMRQTALIVLLAH..IGSFVPA.ASC.ELSLVDRIFT 92 ------........---------------------------..--SFVPA.AQC.ELSLVDRIFT 93 ------........----TGPNMGGKSTYMRQTALIVLLAH..IGSFVPA.AQC.ELSLVDRIFT 94 ------........---------AGKSTYIRQVALIAIMAQ..IGSYVPA.HSA.RIGIIDKVFS 95 ------........---------AGKSTYIRQIALLIIMAQ..MGSFIPA.RSA.HIGMIDKIFT 96 ------........---------AGKSTYIRQIALLVIMAQ..MGSFIPA.KSA.HIGMIDKIFT 97 ------........---------AGKSTYIRQIALLVIMAQ..MGSFIPA.KSA.HIVMIDKIFT 98 ------........---------AGKSTYIRQIALLVIMAQ..MGSFIPA.KAA.HIGIVDKIFT 99 CRLDNEtf......IYLITGPNMSGKSTYMRQVAIISIMAQ..MGAYVPC.KEA.VLPIFDQIFT 100 CDLSPPngeqgga.IWLLTGPNMGGKSTFLRQNALIAIMAQ..TGSFVPA.AAA.HIGVVDRLFS 101 CDLSPPngeqgga.IWLLTGPNMGGKSTFLRQNALIAIMAQ..TGSFVPA.AAA.HIGVVDRLFS 102 LDLHPErr......MLVITGPNMGGKSTYMRQNALIVLLAY..IGSYVPA.SRA.LIGPIDRIMT 103 ----R-r.......MLIITGPNMGGKSTYMRQTALIALMAY..IGSYVPA.QKV.EIGPIDRIFT 104 ----R-r.......MLIITGPNMGGKSTYMRQTALIALMAY..IGSYVPA.QKV.EIGPIDRIFT 105 ------........---------------------------..-------.---.---------- 106 CMMGDNrq......MLLITGPNMSGKSTYMRQIALISIMAQ..IGCFVPA.KKA.VLPIFDQIFT 107 CMMGDNrq......MLLITGPNMSGKSTYMRQIALISIMAQ..IGCFVPA.KKA.VLPIFDQIFT 108 IQMAEDts......IQLVTGPNMSGKSTYMRQLAMTAVMAQ..LGSYVPA.ESA.HLPIFDAIFT 109 TKLTEEef......IHVITGPNMAGKSSYIRQVGVLTLLAH..TGSFLPV.KSA.RIPLVDAIFT 110 TKLDRDsf......IHVITGPNMAGKSSYIRQVGVLTLLSH..IGSFIPA.RRA.KIPVVDALFT 111 IYMDNEkr......FVVITGPNMSGKSTFIRQVGLISLMAQ..IGSFVPA.QKA.ILPVFDRIFT 112 IYMDNEkr......FVVITGPNMSGKSTFIRQVGLISLMAQ..IGSFVPA.QKA.ILPVFDRIFT 113 CHLSEAer......IWLITGPNMAGKSTYLRQNAIITIIAQ..IGSFVPA.KSA.KIGVVDKIFS 114 VTLESGkgd.....FLIITGPNMGGKSTYIRQVGVISLMAQ..IGCFVPC.EEA.EIAIVDAILC 115 VTLESGkgd.....FLIITGPNMGGKSTYIRQVGVISLMAQ..IGCFVPC.EEA.EIAIVDAILC 116 ITFEKEkqm.....FHIITGPNMGGKSTYIRQTGVIVLMAQ..IGCFVPC.DSA.QVSIVDCILA 117 VHFEKDkqm.....FHIITGPNMGGKSTYIRQTGVIVLMAQ..IGCFVPC.ESA.EVSIVDCILA 118 VHFEKDkqm.....FHIITGPNMGGKSTYIRQTGVIVLMAQ..IGCFVPC.ESA.EVSIVDCILA 119 VHFEKDkqm.....FHIITGPNMGGKSTYIRQTGVIVLMAQ..IGCFVPC.ESA.EVSIVDCILA 120 ------........---------------------------..-------.---.---------- 121 VYFEKDkqm.....FHIITGPNMGGKSTYIRQTGVIVLMAQ..IGCFVPC.ESA.EVSIVDCILA 122 ------........---------------------------..-------.---.---------- 123 VYFEKDkqm.....FHIITGPNMGGKSTYIRQTGVIVLMAQ..IGCFVPC.ESA.EVSIVDCILA 124 VYFEKDkqm.....FHIITGPNMGGKSTYIRQTGVIVLMAQ..IGCFVPC.ESA.EVSIVDCILA 125 ------........---------------------------..-------.---.---------- 126 ------........---------------------------..-------.---.---------- 127 VTLTREdss.....FLIITGPNMGGKSTYIRQIGVIALMAQ..IGCFVPC.SSA.ELTIFDSILA 128 VNLEHGsse.....LLIITGPNMGGKSTYIRQVGVITVMAQ..IGCPVPC.EVA.DLDIIDAILA 129 VNLEHGsse.....LLIITGPNMGGKSTYIRQVGVITVMAQ..IGCPVPC.EVA.DLDIIDAILA 130 ------........---------------------------..-------.---.---------- 131 CTLVRGksw.....FQIITGPNMGGKSTFIRQVGVNVLMAQ..VGSFVPC.DQA.SISVRDCIFA 132 ------........----TGPNMGGKSTFIRQVGVIVLMAQ..VGSFVPC.DKA.SISIRDCIFA 133 CRLMRGksw.....FQIVTGPNMGGKSTFIRQVGVIVLMAQ..VGSFVPC.DKA.SISIRDCIFA 134 CRLMRGksw.....FQIVTGPNMGGKSTFIRQVGVIVLMAQ..VGSFVPC.DKA.SISIRDCIFA 135 VDFKKEecn.....MFIITGPNMGGKSTYIRSVGTAVLMAH..IGAFVPC.SLA.TISMVDSILG 136 VDFKKEecn.....MFIITGPNMGGKSTYIRSVGTAVLMAH..IGAFVPC.SLA.TISMVDSILG 137 VDFKKEecn.....MFIITGPNMGGKSTYIRSVGTAVLMAH..IGAFVPC.SLA.TISMVDSILG 138 VSSGRDgik.....ASIITGPNACGKSVYMKSIGIMVFLSH..IGSFVPA.RHA.KIGIVDRIVT 139 VSSGRDgik.....ASIITGPNACGKSVYMKSIGIMVFLSH..IGSFVPA.RHA.KIGIVDRIVT 140 VSSGRDgik.....ASIITGPNACGKSVYMKSIGIMVFLSH..IGSFVPA.RHA.KIGIVDRIVT 141 TDCGGDqgr.....VKVITGPNSSGKSIYLKQVGLITFMAL..VGSFVPA.EEA.EIGVIDAIFT 142 TDCGGDqgr.....VKVITGPNSSGKSIYLKQVGLITFMAL..VGSFVPA.EEA.EIGVIDAIFT 143 TDCGGDqgr.....VKVITGPNSSGKSIYLKQVGLITFMAL..VGSFVPA.EEA.EIGVIDAIFT 144 TECGGDkgr.....VKVITGPNSSGKSIYLKQVGLITFMAL..VGSFVPA.EEA.EIGAVDAIFT 145 TECGGDkgr.....VKVITGPNSSGKSIYLKQVGLITFMAL..VGSFVPA.EEA.EIGAVDAIFT 146 TECGGDkgr.....VKVITGPNSSGKSIYLKQVGLITFMAL..VGSFVPA.EEA.EIGAVDAIFT 147 TECGGDkgr.....VKVITGPNSSGKSIYLKQVGLITFMAL..VGSFVPA.EEA.EIGAVDAIFT 148 TMIDGGlfs14kgrIIVVTGANASGKSVYLTQNGLIVYLAQ..IGCFVPA.ERA.RIGIADKILT 149 TMIDGGlfs14kgrIIVVTGANASGKSVYLTQNGLIVYLAQ..IGCFVPA.ERA.RIGIADKILT 150 ISLEDK........GMLVFSVNGAGKSTLLRAIGVNVILAQ..AGMYVAA.DSF.KLRPYNYLIT 151 ISLEDK........GMLVFSVNGAGKSTLLRAIGVNVILAQ..AGMYVAA.DSF.KLRPYNYLIT 630 640 650 660 670 | | | | | 1 RVGASD.KQSQGISTFMAEMLDCSAI........LQRATKN........SFVVIDELGRGTSTFD 2 RIGASD.NIAKGESTFLVEMNETANI........LRNATEK........SLIIMDEVGRGTSTND 3 RVGSAD.DLYNEMSTFMVEMIETSFI........LQGATER........SLAILDEIGRGTSGKE 4 RVGSAD.DLYNEMSTFMVEMIETSFI........LQGATER........SLAILDEIGRGTSGKE 5 RIGSAD.NLYQQKSTFMVEMMETSFI........LKNATRR........SFVIMDEIGRGTTASD 6 RIG---.-------------------........-------........---------------- 7 RIGSAD.NLYQQKSTFMVEMMETSFI........LKNATRR........SFVIMDEIGRGTTASD 8 I---SK.KRSLDAGAFES-FIRTFTP........VTTSENS........KLILLDELEAITELEA 9 --FKRK.RINYGAGAFESSLKSIVKA........LK-GKGR........KLILIDEFEAITEPGA 10 --FKKK.RSSYGAGAFEGSLKGIVRS........LR-GKGK........KLILIDEFEAITEPGA 11 DIGDPQ.SLEQSLSTFSGHISRIRQI........LDIASEN........SLVLLDEICSGTDPSE 12 DIGDEQ.SIEASLSTFASHLKHLRYV........LRHAAPD........TLVLVDELGSGTDPDE 13 DIGDEQ.SLLQSLSTFSGHLKQISEI........LSHSTSR........SLVLLDEVGAGTNPLE 14 DIGDEQ.SLQQNLSTFSGHICRIIRI........LQALPSGvqd18ifpSLVLLDEVGAGTDPTE 15 DIGDEQ.SIEQSLSTFSSHMVNIVGI........LEQVNEN........SLVLFDELGAGTDPQE 16 DIGDEQ.SIEQSLSTFSSHMTNIVEI........LKNADKH........SLVLFDELGAGTDPSE 17 DIGEEQ.SIEQSLSTFSSHMKKIVEI........VKNADSD........SLVILDELGSGTDPVE 18 DIGDEQ.SIEQNLSTFSAHVKNMAEF........LPKSDEN........TLVLIDELGAGTDPIE 19 DIGDEQ.SISNSLSTFSSHMSNISYI........LKHTTKD........SLVIFDEFCSGTDIDQ 20 IINDPQ.NSANNISTFAGRMKQFSAL........L--SKEN........MLLGVDEIELGTDADE 21 IINDPQ.NSANNISTFAGRMKQFSAL........L--SKEN........MLLGVDEIELGTDADE 22 IIEDPQ.NVKNDISTFAGRMLHFSRL........F--SKKN........LLLGIDEIELGTDFEE 23 IIEDPQ.NVKNDISTFAGRMLHFSRL........F--SKKN........LLLGIDEIELGTDFEE 24 RVC-ND.SMELTSSNFGFEMKEMAYF........LDDINTE........TLLILDELGRGSSIAD 25 RVC-ND.SMELTSSNFGFEMKEMAYF........LDDINTE........TLLILDELGRGSSIAD 26 RIS-SD.NVDINASSFSKEMSETAVI........LNDSDGD........SLILIDELGRGSSLTD 27 RISTDD.DIETNSSTFMKEMKEIAYI........LHNANDK........SLILIDELGRGTNTEE 28 RISTDD.DIETNSSTFMKEMKEIAYI........LHNANDK........SLILIDELGRGTNTEE 29 RMGHND.ELIRNKSAFASEMSDAAAI........VQYADKN........SLVVLDELARSTSTEE 30 RIGAHD.DIINGDSTFKVEMLDILHI........LKNCNKR........SLLLLDEVGRGTGTHD 31 RIGAHD.DIINGDSTFKVEMLDILHI........LKNCNKR........SLLLLDEVGRGTGTHD 32 RMGASD.SIQHGRSTFLEELN-----........-------........------ELGRGTSTHD 33 RMGASD.SIQHGRSTFLEE-------........-------........----LDELGRGTSTHD 34 RMGASD.SIQHGRSTFLEELSEASHI........IRTCSSR........SLVILDELGRGTSTHD 35 RMGAAD.NIYKGRSTFMEQLTDTAEI........IRRASPQ........SLVILDELGRGTSTHD 36 ------.-------------------........-------........---------------- 37 RMGAAD.NIYKGRSTFMEQLTDTAEI........IQ-----........---------------- 38 RMGAAD.NIYKGRSTFMEQLTDTAEI........IRRASPQ........SLVILDELGRGTSTHD 39 RMGAAD.NIYKGRSTFMEQLTDTAEI........IRRASPQ........SLVILDELGRGTSTHD 40 RMGAAD.NIYKGRSTFMEELTDTAEI........IRKATSQ........SLVILDELGRGTSTHD 41 RMGAAD.NIYKGRSTFMEELTDTAEI........IRKATSQ........SLVILDELGRGTSTHD 42 RMGSSD.NLSVNMSTFMVEMLETKEV........LSKATEK........SMVIIDELGRGTSTID 43 RMGSSD.NLSVNMSTFMVEMLETKEV........LSKATEK........SMVIIDELGRGTSTID 44 RIGAND.RIMCGESTFFIELKETDIM........LKNATKH........SLLLVDELGRGTSTFD 45 ------.-------------------........-------........---------------- 46 RLGASD.RIMSGESTFFVELSETASI........LMHATAH........SLVLVDELGRGTATFD 47 ------.-------------------........-------........---------------- 48 RLGASD.RIMSGESTFFVELSETASI........LMHATAH........SLVLVDELGRGTATFD 49 RLGASD.RIMSGESTFFVELSETASI........LMHATAH........SLVLVDELGRGTATFD 50 RLGASD.RIMSGESTFFVELSETASI........LMHATAH........SLVLVDELGRGTATFD 51 RLGASD.RIMSGESTFFVELSETASI........LRHATAH........SLVLVDELGRGTATFD 52 RLGASD.RIMSGESTFFVELSETASI........LRHATAH........SLVLVDELGRGTATFD 53 RLGATD.RIMTGESTFLVECTETASV........LQKATVD........SLVLLDELGRGTSTFD 54 RLGATD.RIMTGESTFLVECTETASV........LQKATVD........SLVLLDELGRGTSTFD 55 RLGASD.RIMTGESTFLVECTETASV........LQNATQD........SLVILDELGRG----- 56 RLGASD.RIMTGESTFLVECTETASV........LQNATQD........SLVILDELGRGTSTFD 57 ------.-------------------........-------........---------------- 58 RIGAMD.RIMSGESTFLVECTETASI........LENATED........SLVLLDELGSGTTTYD 59 RMGARD.HIMAGQSTFLVELEETASV........LSSATKN........SLVVLDELGRGTSTSD 60 RMGAKD.HIMAGQSTFLTELSETAVM........LTSATRN........SLVVLDELGRGTATSD 61 RMGAKD.HIMAGQSTFLTELSETAVM........LTSATRN........SLVVLDELGRGTATSD 62 RLGAND.DIMSARSTFMVELSETKKI........LDECGPK........SLVILDELGRGTSTYD 63 RLGAND.NIMQGKSTFFVELAETKKI........LDMATNR........SLLVVDELGRGGSSSD 64 RLGAND.NIMQGKSTFFVELAETKKI........LDMATNR........SLLVVDELGRGGSSSD 65 RVGAAD.NLARGESTFLVEMSETAHI........LRAATRD........SLVIMDEVGRGTATED 66 RIGASD.DLAGGKSTFMVEMEEVALI........LKEATEN........SLVLLDEVGRGTSSLD 67 RIGASD.DLAGGKSTFMVEMEEVALI........LKEATEN........SLVLLDEVGRGTSSLD 68 RIGASD.DLAGGKSTFMVEMEEVALV........LKEATER........SLVLLDEVGRGTSSLD 69 RIGASD.DLAGGKSTFMVEMEEVALV........LKEATER........SLVLLDEVGRGTSSLD 70 RIGASD.DLAGGKSTFMVEMEEVALV........LKEATER........SLVLLDEVGRGTSSLD 71 RIGASD.DLAGGKSTFMVEMEEVALV........LKEATER........SLVLLDEVGRGTSSLD 72 RVGAVD.DLATGQSTFMVEMNETANI........LNHATAK........SLVLLDEIGRGTATFD 73 RVGAVD.DLATGQSTFMVEMNETANI........LNHATAK........SLVLLDEIGRGTATFD 74 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEVGRGTSTYD 75 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEVGRGTSTYD 76 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEIGRGTSTYD 77 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEIGRGTSTYD 78 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEIGRGTSTYD 79 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEVGRGTSTYD 80 RIGASD.DLASNRSTFMVEMSETAYI........LHHATEQ........SLVLMDEVGRGTSTFD 81 RIGASD.DLASNRSTFMVEMSETAYI........LHHATEQ........SLVLMDEVGRGTSTFD 82 RIGASD.DLASGRSTFMVEMTEMANI........LHQATAQ........SLVLIDEIGRGTSTYD 83 RVGAAD.DLASGRSTFMVEMTETANI........LHNATEY........SLVLMDEIGRGTSTYD 84 RVGAAD.DLASGRSTFMVEMTETANI........LHNATEY........SLVLMDEIGRGTSTYD 85 RVGAAD.DLASGRSTFMVEMTETANI........LHNATEY........SLVLMDEIGRGTSTYD 86 RVGAAD.DLASGRSTFMVEMTETANI........LHNATEN........SLVLMDEIGRGTSTYD 87 RVGAAD.DLASGRSTFMVEMTETANI........LHNATEN........SLVLMDEIGRGTSTYD 88 RIGSSD.DLAGGRSTFMVEMSETANI........LHNASER........SLVLMDEVGRGTSTFD 89 RIGSSDxDLAGGRSTFMVEMSETANI........LHNATDK........SLVLMDEVGRGTSTFD 90 RIGSSD.DLAGGRSTFMVEMSETANI........LHNATDK........SLVLMDEVGRGTSTFD 91 RIGSSD.DLAGGRSTFMVEMSETANI........LHNATDR........SLVLMDEMGRGTSTFD 92 RIGSSD.DLAGGRSTFMVEMSETANI........LHNATDR........SLVLMDEVGRGTSTFD 93 RIGSSD.DLAGGRSTFMVEMSETANI........LHNATDR........SLVLMDEVGRGTSTFD 94 RIGASD.DLARGQSTFMVEMTETANI........LNNASPR........SLVILDEIGRGTSTYD 95 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLIVLDEVGRGTSTYD 96 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEVGRGTSTYD 97 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEVGRGTSTYD 98 RIGAGD.NLAKGMSTFMVEMTETANI........LHNATNR........SLVILDEIGRGTSTYD 99 RIGAAD.DLVSGKSTFMVEMLEAQKA........LTYATED........SLIIFDEIGRGTSTYD 100 RVGASD.DLARGRSTFMVEMVETAAI........LNQATDR........SLVILDEIGRGTATFD 101 RVGASD.DLARGRSTFMVEMVETAAI........LNQATDR........SLVILDEIGRGTATFD 102 RIGAGD.DLARGQSTFMLEMTETSYI........LHHATAQ........SLVLMDEIGRGTSTYD 103 RVGAAD.DLASGRSTFMVEMTETANI........LHNATEY........SLVLMDEIGRGTSTYD 104 RVGAAD.DLASGRSTFMVEMTETANI........LHNATEY........SLVLMDEIGRGTSTYD 105 ------.-------------------........-------........---------------- 106 RIGAAD.DLISGQSTFMVEMLEAKNA........IVNATKN........SLILFDEIGRGTSTYD 107 RIGAAD.DLISGQSTFMVEMLEAKNA........IVNATKN........SLILFDEIGRGTSTYD 108 RIGAAD.DLVSGQSTFMVEMMEANNA........ISHATKN........SLILFDELGRGTATYD 109 RIGSGD.VLALGVSTFMNEMLDVSNI........LNNATKR........SLIILDEVGRGTSTYD 110 RIGSGD.VLALGVSTFMNEMLEVSNI........LNNATEK........SLVILDEVGRGTSTYD 111 RMGARD.DLAGGRSTFLVEMNEMALI........LLKSTNK........SLVLLDEVGRGTSTQD 112 RMGARD.DLAGGRSTFLVEMNEMALI........LLKSTNK........SLVLLDEVGRGTSTQD 113 RIGAAD.DLIKGQSTFMAEMLETSAI........LAQSTKN........SLIILDEVGRGTSTYD 114 RVGAGD.SQLKGVSTFMVEILETASI........LKNASKN........SLIIVDELGRGTSTYD 115 RVGAGD.SQLKGVSTFMVEILETASI........LKNASKN........SLIIVDELGRGTSTYD 116 RVGAGD.SQLKGVSTFMAEMLETASI........LRSATEN........SLIIIDELGRGTSTYD 117 RVGAGD.SQLKGVSTFMAEMLETASI........LRSATKD........SLIIIDELGRGTSTYD 118 RVGAGD.SQLKGVSTFMAEMLETASI........LRSATKD........SLIIIDELGRGTSTYD 119 RVGAGD.SQLKGVSTFMAEMLETSSI........LRSATKD........SLIIIDELGRGTSTYD 120 ------.-------------------........-------........---------------- 121 RVGAGD.SQLKGVSTFMAEMLETASI........LRSATKD........SLIIIDELGRGTSTYD 122 ------.-------------------........-------........---------------- 123 RVGAGD.SQLKGVSTFMAEMLETASI........LRSATKD........SLIIIDELGRGTSTYD 124 RVGAGD.SQLKGVSTFMAEMLETASI........LRSATKD........SLIIIDELGRGTSTYD 125 ------.-------------------........-------........---------------- 126 ------.-------------------........-------........---------------- 127 RVGASD.SQLKGVSTFMAEMLETANI........LKSATAE........SLIIIDELGRGTSTYD 128 RVGASD.SQLKGISTFMAEMLETATI........LRAATPR........SLIIIDELGRGTSTTD 129 RVGASD.SQLKGISTFMAEMLETATI........LRAATPR........SLIIIDELGRGTSTTD 130 ------.-------------------........-------........---------------- 131 RVGAGD.CQLHGVSTFMQEMLETASI........LKGASDK........SLIIIDELGRGTSTYD 132 RVGAGD.CQLRGVSTFMQEMLETASI........LKGATDK........SLIIIDELGRGTSTYD 133 RVGAGD.CQLRGVSTFMQEMLETASI........LKGATDK........SLIIIDELGRGTSTYD 134 RVGAGD.CQLRGVSTFMQEMLETASI........LKGASDK........SLIIIDELGRGTSTYD 135 RVGASD.NIIKGLSTFMVEMIETSGI........IRTATDK........SLVIIDELGRGTSTYE 136 RVGASD.NIIKGLSTFMVEMIETSGIirv24cgiLQTATDK........SLVIIDELGRGTSTYE 137 RVGASD.NIIKGLSTFMVEMIETSGI........IRTATDK........SLVIIDELGRGTSTYE 138 RMFTVD.SVLDGMSTFAKDVEQVALA........LRKATGN........SLVIIDEFGKGTMTEV 139 RMFTVD.SVLDGMSTFAKDVEQVALA........LRKATGN........SLVIIDEFGKGTMTEV 140 RMFTVD.SVLDGMSTFAKDVEQVALA........LRKATGN........SLVIIDEFGKGTMTEV 141 RIHSCE.SISLGLSTFMIDLNQVAKA........VNNATEH........SLVLIDEFGKGTNSVD 142 RIHSCE.SISLGLSTFMIDLNQVAKA........VNNATEH........SLVLIDEFGKGTNSVD 143 RIHSCE.SISLGLSTFMIDLNQVAKA........VNNATEH........SLVLIDEFGKGTNSVD 144 RIHSCE.SISLGLSTFMIDLNQVAKA........VNNATAQ........SLVLIDEFGKGTNTVD 145 RIHSCE.SISLGLSTFMIDLNQVAKA........VNNATAQ........SLVLIDEFGKGTNTVD 146 RIHSCE.SISLGLSTFMIDLNQVAKA........VNNATAQ........SLVLIDEFGKGTNTVD 147 RIHSCE.SISLGLSTFMIDLNQVAKA........VNNATAQ........SLVLIDEFGKGTNTVD 148 RIRTQE.TVYKTQSSFLLDSQQMAKS........LSLATEK........SLILIDEYGKGTDILD 149 RIRTQE.TVYKTQSSFLLDSQQMAKS........LSLATEK........SLILIDEYGKGTDILD 150 RILGGD.DLYRGQGTFEVEMRDLSTI........LQLANYN........SLILGDEICHGTEVNS 151 RILGGD.DLYRGQGTFEVEMRDLSTI........LQLANYN........SLILGDEICHGTEVNS 680 690 700 710 | | | | 1 GFGIASAIAQDILNr...IQCLSIFATHFHEMGKLa.......EQPGAVALQMGVQI........ 2 GLAIAYSIIEYILEy...IKARSLFATHFHELSSI........NHQAFINLSMKIEK........ 3 GISIAYATLKYLLEn...NQCRTLFATHFGQELKQiid9cskgMSEKVKFYQSGITD........ 4 GISIAYATLKYLLEn...NQCRTLFATHFGQELKQiid9cskgMSEKVKFYQSGITD........ 5 GIAIAYGCLKYLSTi...NHSRTLFATHAHQLTNLtksf....KNVECYCTNLSIDR........ 6 --------------....-----------------........--------------........ 7 GIAIAYGCLKYLSTi...NHSRTLFATHAHQLTNLtksf....KNVECYCTNLSIDR........ 8 AVKIIATFIEFIGE....SSSLAVIVTHMAREIMKy.......VDVRVDGIEARGLD........ 9 AAKILAELLKIGVE....KGFYIVIVSHLGEDLKKel......PYARVDGIEASGLD........ 10 AVKILAELLKVGIS....KGFYIVIVSHLGEDLMKel......PEARVDGIEASGLD........ 11 GVALATSILQYIKN....RVNVAVVSTHYGDLSRL........KDNEPRFQNAAMEF........ 12 GAALAQSLIETLLE....QDARGIITSHLSPLKLF........ALETPGLKNASMGF........ 13 GAALGMAILESFAEs...GSLLTMATTHHGELKTL........KYSNSAFENACMEF........ 14 GSALAIALLRHLAD....QPCLTVATTHYGELKAL........KYQDARFENASVEF........ 15 GAALAMSILDDVHR....TNARVLATTHYPELKAY........GYNREGVMNASVEF........ 16 GAALAMSILDHVRK....IGSLVMATTHYPELKAY........SYNREGVMNASVEF........ 17 GAALAIAIIEDLLE....KGATIFVTTHLTPVKVF........AMNHPLLLNASMEF........ 18 GSALGIGILEYLKK....KKAWVFVTTHHTPIKLY........STNSDYYTPASVLF........ 19 GQALAISILEYLIN....INSYVLISTHYNALKYF........AYTHEGVVNASMRM........ 20 ASSLYKTLLEKLLK....QNNQIIITTHHKRLSVL........MAENKEVELLAALY........ 21 ASSLYKTLLEKLLK....QNNQIVITTHHKRLSVL........MAENKEVELLAALY........ 22 AACLYSVLISKLIA....NNLKIIITTHHKRLAML........LAKNEQVELIAALY........ 23 AACLYSVLISKLIA....NNLKIIITTHHKRLAML........LAKNEQVELIAALY........ 24 GFCVSLAVTEHLLR....TEATVFLSTHFQDIPKIms......KKPAVSHLHMDAVL........ 25 GFCVSLAVTEHLLR....TEATVFLSTHFQDIPKIms......KKPAVSHLHMDAVL........ 26 GFSICLAILEDLIC....KEATVITTTHFRDIAQVla......NKSCVVTAHMQTVE........ 27 GIGICYAVCEYLLS....LKAFTLFATHFLELCHIda......LYPNVENMHFEVQH........ 28 GIGICYAVCEYLLS....LKAFTLFATHFLELCHIda......LYPNVENMHFEVQH........ 29 GIAITYAICEKVLK....LQSYTFLATHFLDIAALan......YSNAIDNYHFLPQT........ 30 GIAISYALIKYFSEls..DCPLILFTTHFPMLGEI........KSPLIRNYHMDYVE........ 31 GIAISYALIKYFSEls..DCPLILFTTHFPMLGEI........KSPLIRNYHMDYVE........ 32 GVAIAYATLQHLLAe...KRCLVLFVTHYPEIAEIsng.....FPGSVGTYHVSYLTlqkdkgsy 33 GVAIAYATLQHLLAe...KRCLVLFVTHYPEIAEIsng.....FPGSVGTYHVSYLTlqkdkgsy 34 GVAIAYATLQHLLAe...KRCLVLFVTHYPEIAEIsng.....FPGSVGTYHVSYLTlqkdkgsy 35 GIAIAYATLEYFIRd...VKSLTLFVTHYPPVCELekc.....YPEQVGNYHMGFLV........ 36 --------------....-----------------........--------------........ 37 --------------....-----------------........--------------........ 38 GIAIAYATLEYFIRd...VKSLTLFVTHYPPVCELekc.....YPEQVGNYHMGFLV........ 39 GIAIAYATLEYFIRd...VKSLTLFVTHYPPVCELekc.....YPEQVGNYHMGFLV........ 40 GIAIAYATLEYFIRd...VKSLTLFVTHYPPVCELekn.....YSHQVGNYHMGFLV........ 41 GIAIAYATLEYFIRd...VKSLTLFVTHYPPVCELekn.....YSHQVGNYHMGFLV........ 42 GEAISYAVLHYLNQy...IKSYLLFVTHFPSLGILerr.....FEGQLRCFHMGYLK........ 43 GEAISYAVLHYLNQy...IKSYLLFVTHFPSLGILerr.....FEGQLRCFHMGYLK........ 44 GTAIASAVLQKISDd...LACRTFFSTHYHSICDSft......NHPNVRLAHMKCVV........ 45 --------------....-----------------........--------------........ 46 GTAIANAVVKELAEt...IKCRTLFSTHYHSLVEDys......QNVAVRLGHMACMV........ 47 --------------....-----------------........--------------........ 48 GTAIANAVVKELAEt...IKCRTLFSTHYHSLVEDys......QNVAVRLGHMACMV........ 49 GTAIANAVVKELAEt...IKCRTLFSTHYHSLVEDys......QNVAVRLGHMACMV........ 50 GTAIANAVVKELAEt...IKCRTLFSTHYHSLVEDys......QNVAVRLGHMACMV........ 51 GTAIANAVVKELAEt...IKCRTLFSTHYHSLVEDys......KSVCVRLGHMACMV........ 52 GTAIASAVVKELAEt...IKCRTLFSTHYHSLVEDys......KSVCVRLGHMACMV........ 53 GYAIAYAVFRHLVEr...VRCRQLFATHYHSLTKEfa......SHPHVSLQHMACMF........ 54 GYAIAYAVFRHLVEr...VRCRQLFATHYHSLTKEfa......SHPHVSLQHMACMF........ 55 --------------....-----------------........--------------........ 56 GYAIAYSVFRHLVEk...VQCRMLFATHYHPLTKEfa......SHPRVTSKHMACAF........ 57 --------------....-----------------........--------------........ 58 G-------------....-----------------........--------------........ 59 GQAIAASVLEYLVHq...VQCLGLFSTHYHRLAMEh.......NDTKVSLCHMACEV........ 60 GQAIAESVLEHFIEk...VQCRGFFSTHYHRLSVDyq......TNPKVSLCHMACQI........ 61 GQAIAESVLEHFIEk...VQCRGFFSTHYHRLSVDyq......TNPKVSLCHMACQI........ 62 GHAIAYAVLHHLVSn...IGCLGFFSTHYQSLCVDfm......HHRQVRLMQMAAAV........ 63 GFAIAESVLHHVATh...IQSLGFFATHYGTLASSfk......HHPQVRPLKMSILV........ 64 GFAIAESVLHHVATh...IQSLGFFATHYGTLASSfk......HHPQVRPLKMSILV........ 65 GLSIAQAVSEYLLHh...VRAKTLFATHYHELSRL........AHPQLEHLKLDVLE........ 66 GVAIATAVAEALHE....RRAYTLFATHYFELTAL........GLPRLKNLHVAARE........ 67 GVAIATAVAEALHE....RRAYTLFATHYFELTAL........GLPRLKNLHVAARE........ 68 GVAIATALAEALHE....RRCYTLFATHYFELTAL........ALPRLKNLHVAAKE........ 69 GVAIATALAEALHE....RRCYTLFATHYFELTAL........ALPRLKNLHVAAKE........ 70 GVAIATALAEALHE....RRCYTLFATHYFELTAL........ALPRLKNLHVAAKE........ 71 GVAIATALAEALHE....RRCYTLFATHYFELTAL........ALPRLKNLHVAAKE........ 72 GLAIAWSVAEYLAGe...IQARTIFATHYHELNELas......LLENVANFQVTVKE........ 73 GLAIAWSVAEYLAGe...IQARTIFATHYHELNELas......LLENVANFQVTVKE........ 74 GLAIAQAVVEYLLFtdk.KKAKTLFATHYKELTTLed......HCPHVENFHAGVKD........ 75 GLAIAQAVVEYLLFtdk.KKAKTLFATHYKELTTLed......HCPHVENFHAGVKD........ 76 GLAIAQAVVEFLLFtdg.KKAKTLFATHYKELTELem......HCQHVENFHAMVKE........ 77 GLAIAQAVVEFLL-....-----------------........--------------........ 78 GLAIAQAVVEFLL-....-----------------........--------------........ 79 GLAIAQAVVEFLLFteg.KKAKTLFATHYKELTELel......HCQHVENFHAVVKE........ 80 GLALAHAVAEHLLQk...NKSFSLFATHYFELTYLpe......AHAAAVNMHLSALE........ 81 GLALAHAVAEHLLQk...NKSFSLFATHYFELTYLpe......AHTAAVNMHLSALE........ 82 GLSLAWACAEWLSKk...IRSLTLFATHYFELTALpe......QLEGIANIHLDALE........ 83 GLSLAWACAENLANk...IKALTLFATHYFELTQLpe......KMEGVANVHLDALE........ 84 GLSLAWACAENLANk...IKALTLFATHYFELTQLpe......KMEGVANVHLDALE........ 85 GLSLAWACAENLANk...IKALTLFATHYFELTQLpe......KMEGVANVHLDALE........ 86 GLSLAWACAENLANk...IKALTLFATHYFELTQLpe......KMEGVANVHLDALE........ 87 GLSLAWACAENLANk...IKALTLFATHYFELTQLpe......KMEGVANVHLDALE........ 88 GLSLAWAAAEHLAG....LRAWTLFATHYFELTVLae......SQPVVANVHLSATE........ 89 GLSLAWAAAEDLAR....TRAFTLFATHYFELTVLpe......SQPAVANVHLNATE........ 90 GLSLAWAAAEDLAR....TRAFTLFATHYFELTVLpe......SQPAVANVHLNATE........ 91 GLSLAWAAAERLAQ....LRAYTLFATHYFELTVLpe......SEPLVANVHLNATE........ 92 GLSLAWAAAERLAQ....LRAYTLFATHYFELTVLpe......SEPLVANVHLNATE........ 93 GLSLAWAAAECLAQ....LRAYTLFATHY------........--------------........ 94 GISIAWAVAEHLL-....-----------------........--------------........ 95 GLAIAQSVVEYLL-....-----------------........--------------........ 96 GLAIAQSVVEYLL-....-----------------........--------------........ 97 GLAIAQSVVEYLL-....-----------------........--------------........ 98 GLAIAQAVVEYLL-....-----------------........--------------........ 99 GLALAQAMIEYVAEt...SHAKTLFSTHYHELTTLdq......ALPSLKNVHVAANE........ 100 GLSIAWAAVEHLHEv...NRCRGLFATHFHELTVLse......KLVRLSNATMRVKE........ 101 GLSIAWAAVEHLHEv...NRCRGLFATHFHELTVLse......KLVRLSNATMRVKE........ 102 GLALADAVARHLAHi...NRCYTLFATHYFELTALadetyeg.GLSGIANVHFDAVE........ 103 GLSLAWACAENLANk...IKALTLFATHYF-----........--------------........ 104 GLSLAWACAENLANk...IKALTLFATHY------........--------------........ 105 --------------....-----------------........--------------........ 106 GMALAQAIIEYVHDh...IGAKTLFSTHYHELTVLed......KLPQLKNVHVRAEE........ 107 GMALAQAIIEYVHDh...IGAKTLFSTHYHELTVLed......KLPQLKNVHVRAEE........ 108 GMALAQSIIEYIHEh...IGAKTLFATHYHELTSLes......SLQHLVNVHVATLE........ 109 GIAISKAIVKYISEk...IGAKTLLATHYLELTELer......KVKGVKNYHMEVEE........ 110 GIAISKAIVKYISEk...LKAKTLLATHFLEITELeg......KIEGVKNYHMEVEK........ 111 GVSIAWAISEELIK....RGCKVLFATHFTELTELek......HFPQVQNKTILVKE........ 112 GVSIAWAISEELIK....RGCKVLFATHFTELTELek......HFPQVQNKTILVKE........ 113 GVSIAWSVLEYIHDk...LQCRCLFATHYHELTVMkn......FLPALQNYTIAIEE........ 114 GFGLAWAIAEHIASk...IGCFALFATHFHELTELse......KLPNVKNMHVVAHIekn9eqkh 115 GFGLAWAIAEHIASk...IGCFALFATHFHELTELse......KLPNVKNMHVVAHIekn9eqkh 116 GFGLAWAISEYISTk...IKAFCMFATHFHELTALad......QVPTVNNLHVTALT........ 117 GFGLAWAISEYIATn...IGAFCMFATHFHELTALas......QIPTVNNLHVTALT........ 118 GFGLAWAISDYIATk...IGAFCMFATHFHELTALan......QIPTVNNLHVTALT........ 119 GFGLAWAISDYIATk...IGAFCMFATHFHELTALan......QIPTVNNLHVTALT........ 120 --------------....-----------------........--------------........ 121 GFGLAWAISEYIATk...IGAFCMFATHFHELTALan......QIPTVNNLHVTALT........ 122 --------------....-----------------........--------------........ 123 GFGLAWAISEYIATk...IGAFCMFATIFMNL---........--------------........ 124 GFGLAWAISEYIATk...IGAFCMFATHFHELTALan......QIPTVNNLHVTALT........ 125 --------------....-----------------........--------------........ 126 --------------....-----------------........--------------........ 127 GFGLAWAISEHIVKe...IGCFALFATHFHELTALad......QYPNVKNLHVTAHI........ 128 GFGLAWAITEHIVTq...IGCFCLFATHYHEMTKLse......EITTVKNLHVTAYV........ 129 GFGLAWAITEHIVTq...IGCFCLFATHYHEMTKLse......EITTVKNLHVTAYV........ 130 --------------....-----------------........--------------........ 131 GFGLAWAICEHLMEv...TRAPTLFATHFHELTALahr11qhiSDIGVANYHVGAHI........ 132 GFGLAWAICEHLVQv...KRAPTLFATHY------........--------------........ 133 GFGLAWAICEHLVQv...KRAPTLFATHFHELTALaqa9evsgNTVGVANFHVSAHI........ 134 GFGLAWAICEHLVQv...KRAPTLFATHFHELTALaqa9evsgNTVGVANFHVSAHI........ 135 GCGIAWSIAEHLAKe...TKCFTLFATHFHEITKLae......TLSTVKNCHMAAVA........ 136 GCGIAWSIAEHLAKe...TKCFTLFATHFHEITKLae......TLSTVKNCHMAAVA........ 137 GCGIAWSIAEHLAKe...TKCFTLFATHFHEITKLae......TLSTVKNCHMAAVA........ 138 GLSLLASVMTYWMNrgadRCPHIFLSSHFHALPNYipl.....ETNIATFLTFTVLR........ 139 GLSLLASVMTYWMNrgadRCPHIFLSSHFHALPNYipl.....ETNIATFLTFTVLR........ 140 GLSLLASVMTYWMNrgadRCPHIFLSSHFHALPNYipl.....ETNIATFLTFTVLR........ 141 GLALLAAVLRHWLAlgp.SCPHVFVATNFLSLVQLq.......--------------........ 142 GLALLAAVLRHWLAlgp.SCPHVFVATNFLSLVQLqllp....QGPLVQYLTMETCE........ 143 GLALLAAVLRHWLAlgp.SCPHVFVATNFLSLVQLqllp....QGPLVQYLTMETCE........ 144 GLALLAAVLRHWLArgp.TCPTVFVATNFLSLVQLqllp....QGPLVQYLTMETCE........ 145 GLALLAAVLRHWLArgp.TCPHIFVATNFLSLVQLqllp....QGPLVQYLTMETCE........ 146 GLALLAAVLRHWLArgp.TCPHIFVATNFLSLVQLqllp....QGPLV---------........ 147 GLALLAAVLRHWLArgp.TCPHIFVATNFLSLVQLqllp....QGPLVQYLTMETCE........ 148 GPSLFGSIMLNMSKse..KCPRIIACTHFHELFNEnvl21isqKYNLLETAHVGEDH........ 149 GPSLFGSIMLNMSKse..KCPRIIACTHFHELFNEnvl21isqKYNLLETAHVGEDH........ 150 GTAILAATIERLIN....AQTSFVLSTHLHQVCSL........IDSPVRYYHLSVIQ........ 151 GTAILAATIERLIN....AQTSFVLSTHLHQVCSL........IDSPVRYYHLSVIQ........ 720 730 740 750 760 | | | | | 1 ENNE........IHMLYKVFEGVAQ.CSFGLQVAKMVG.IDENVINK.AAQLLEGL..EK..... 2 QGND........LVFLREVEEKPSL.NSYGIYVARIAG.LPLRVIDR.ANVILESL..VG..... 3 LGGNn.......FCYNHKLKPGICT.KSDAIRVAELAG.FPMEALKE.AREI----..--..... 4 LGGNn.......FCYNHKLKPGICT.KSDAIRVAELAG.FPMEALKE.AREI----..--..... 5 DDHT........FSFDYKLKKGVNY.QSHGLKVAEMAG.IPKNVLLA.AEEVL---..--..... 6 ----........-------------.------------.--------.--------..--..... 7 DDHT........FSFDYKLKKGVNY.QSHGLKVAEMAG.IPKNVLLA.AEEVL---..--..... 8 DDYN........LIVDRTPRINYLA.RS----------.TPELIIRM.IYEKSSDD..ER..... 9 EELN........LIVDRQPKFGVIG.KS----------.TPELILER.LARKGRGE..ER..... 10 ENLN........LIVDRQPKFGIIG.RS----------.TPELILERlARKGRGEE..RD..... 11 SMET........LQPTFRVLWGSTG.LSNALRVAKSIG.FNKRILEN.AHKWTEKLnpEQ..... 12 AVGT........LAPTYQLQVGQPG.RSYALAIANRMG.LPRDVLSR.AEELLGPE..AG..... 13 DDLN........LKPTYKILWGVPG.RSNAINIADRLG.LPCDIIES.ARELYGSA..SA..... 14 DDQS........LSPTYRLLWGIPG.RSNALAIAQRLG.LPLAIVEQ.AKDKLGGF..SE..... 15 DIET........LSPTYKLLIGVPG.RSNAFEISKRLG.LPDHIIGQ.AKSEMTAE..HN..... 16 DVDT........LSPTYKLLMGVPG.RSNAFDISKKLG.LSLNIINK.AKTMIGTD..EK..... 17 DPET........LSPTYRVLVGVPG.GSHAFQIAEKLG.LDKRIIEN.ARSRLSRE..EM..... 18 DRET........LKPLYKIAYNTVG.ESMAFYIAQKYG.IPSEVIEI.AKRHVGEF..GE..... 19 DLET........MQPNYNLIFSIPG.ESYAFNVASKAL.IDRSIVIR.ANEIYSSQ..KT..... 20 DEEK........ERPTYTFLKGVIG.KSYAFETALRYG.VPHFLIEK.AKTFYGED..KE..... 21 DEEK........ERPTYTFLKGVIG.KSYAFETALRYG.VPPFLIEK.AKAFYGED..KE..... 22 DEEL........SRPKYEFLKGTIG.KSYAFETALRYQ.IPPNLVSE.AKKLYGED..KE..... 23 DEEL........SRPKYEFLKGTIG.KSYAFETALRYQ.IPPNLVSE.AKKLYGED..KG..... 24 LNDNs.......VKMNYQLTQKSVAiENSGIRVVKKI-.FNPDIIAE.AYNMDS--..--..... 25 LNDNs.......VKMNYQLTQKSVAiENSGIRVVKKI-.FNPDIIAE.AYNIHSLL..--..... 26 TNGQ........LEMKYNLVLGRNDiVGYGIRFAEVSNlLPQELIED.SKVVANIL..RS..... 27 VKNTsrnkea..ILYTYKLSKGLTEeKNYGLKAAEVSS.LPPSIVLD.AKEITTQI..TR..... 28 VKNTsrnkea..ILYTYKLSKGLTEeKNYGLKAAEVSS.LPPSIVLD.AKEITTQI..TR..... 29 DENS........-TKKHKLLRGQYRgPLYGFELVELST.IPDEVIEH.AQSLATEL..RA..... 30 EQKTgedwms..VIFLYKLKKGLTY.NSYGMNVAKLAR.LDKDIINR.AFSISEEL..RK..... 31 EQKTgedwms..VIFLYKLKKGLTY.NSYGMNVAKLAR.LDKDIINR.AFSISEEL..RK..... 32 DHDD........VTYLYKLVRGLCS.RSFGFKVAQLAQ.IPPSCIRR.AISMAAKL..EA..... 33 DHDD........VTYLYKLVRGLCS.RSFGFKVAQLAQ.IPPSCIRR.AISMAAKL..EA..... 34 DHDD........VTYLYKLVRGLCS.RSFGFKVAQLAQ.IPPSCIRR.AISMAAKL..EA..... 35 NEDEskq14pdsVTFLYQITRGIAA.RSYGLNVAKLAD.VPREVLQK.AAHKSKEL..EG..... 36 ----........-------------.------------.--------.--------..--..... 37 ----........-------------.------------.--------.--------..--..... 38 NEDEskq14pdsVTFLYQITRGIAA.RSYGLNVAKLAD.VPREVLQK.AAHKSKEL..EG..... 39 NEDEskq14pdsVTFLYQITRGIAA.RSYGLNVAKLAD.VPREVLQK.AAHKSKEL..EG..... 40 SEDEskl14pdfVTFLYQITRGIAA.RSYGLNVAKLAD.VPGEILKK.AAHKSKEL..EG..... 41 SEDEskl14pdfVTFLYQITRGIAA.RSYGLNVAKLAD.VPGEILKK.AAHKSKEL..EG..... 42 SKEDfetsvsqsISFLYKLVPGVAS.KSYGLNVARMAG.IPFSILSR.ATEISE--..--..... 43 SKEDfetsvsqsISFLYKLVPGVAS.KSYGLNVARMAG.IPFSILSR.ATEISENY..EK..... 44 DKENnedptmedVTFLYELESGICP.KSYGFYAAKLAG.IDHQVVRN.AYLESNKF..ASnl... 45 ----........-------------.------------.--------.--------..--..... 46 ENECedpsqet.ITFLYKFIKGACP.KSYGFNAARLAN.LPEEVIQK.GHRKAREF..EK..... 47 ----........-------------.------------.--------.--------..--..... 48 ENECedpsqet.ITFLYKFIKGACP.KSYGFNAARLAN.LPEEVIQK.GHRKAREF..EK..... 49 ENECedpsqet.ITFLYKFIKGACP.KSYGFNAARLAN.LPEEVIQK.GHRKAREF..EK..... 50 ENECedpsqet.ITFLYKFIKGACP.KSYGFNAARLAN.LPEEVIQK.GHRKAREF..EK..... 51 ENECedpsqet.ITFLYKFIKGACP.KSYGFNAARLAN.LPEEVIQK.GHRKAREF..ER..... 52 ENECedpsqet.ITFLYKFIKGACP.KSYGFNAARLAN.LPEEVIQK.GHRKAREF..ER..... 53 KPRSdgngqke.LTFLYRLTSGACP.ESYGLQVAAMAG.IPKSIVEK.ASVAGQVM..RA..... 54 KPRSdgngqke.LTFLYRLTSGACP.ESYGLQVAAMAG.IPKSIVEK.ASVAGQVM..RA..... 55 ----........-------------.------------.--------.--------..--..... 56 KSRSdyq10dqdLVFLYRLTEGACP.ESYGLQVALMAG.IPNQVVET.ASGAAQAM..KR..... 57 ----........-------------.------------.--------.--------..--..... 58 ----........-------------.------------.--------.--------..--..... 59 VEGGgglee...VTFLYRLTPGACP.KSYGVNVARLAG.IPTKLLQR.ANEKSSEF..EA..... 60 GEGIggvee...VTFLYRLTPGACP.KSYGVNVARLAG.LPDYVLQR.AVIKSQEF..EA..... 61 GEGIggvee...VTFLYRLTPGACP.KSYGVNVARLAG.LPDYVLQR.AVIKSQEF..EA..... 62 DEKIrr......VTFLYKLEDGICP.KSYGMNVASMAG.LPEKVIDA.AEEKASEL..EQ..... 63 DEATrn......VTFLYKMLEGQSE.GSFGMHVASMCG.ISKEIIDN.AQIAADNL..EH..... 64 DEATrn......VTFLYKMLEGQSE.GSFGMHVASMCG.ISKEIIDN.AQIAADNL..EH..... 65 TDNT........IVFLKKVTPGSCG.SSYGIYVARLAG.LPESVLAR.ACELLKQL..QQ..... 66 EAGG........LVFYHQVLPGPAS.KSYGVEVAAMAG.LPKEVVAR.ARALLQAM..AA..... 67 EAGG........LVFYHQVLPGPAS.KSYGVEVAAMAG.LPKEVVAR.ARALLQAM..AA..... 68 EEGG........LVFYHQVLPGPAS.KSYGVEVAEMAG.LPKEVVER.ARALLSAM..AA..... 69 EEGG........LVFYHQVLPGPAS.KSYGVEVAEMAG.LPKEVVER.ARALLSAM..AA..... 70 EEGG........LVFYHQVLPGPAS.KSYGVEVAEMAG.LPKEVVER.ARALLSAM..AA..... 71 EEGG........LVFYHQVLPGPAS.KSYGVEVAEMAG.LPKEVVER.ARALLSAM..AA..... 72 LPEE........IIFLHQVTPGGAD.KSYGIEAGRLAG.LPSSVITR.ARQVMAQI..EK..... 73 LPEE........IIFLHQVTPGGAD.KSYGIEAGRLAG.LPSSVITR.ARQVMAQI..EK..... 74 KAGQ........PVFLYEILKGHSQ.KSFGIHVARLAG.FPLCVVSR.AQQILRQL..EG..... 75 KAGQ........PVFLYEILKGHSQ.KSFGIHVARLAG.FPLCVVSR.AQQILRQL..EG..... 76 NSGQ........PIFMYEIVKGHSK.KSFGIHVAKLAG.FPLSVVSR.AQQILHQF..EG..... 77 ----........-------------.------------.--------.--------..--..... 78 ----........-------------.------------.--------.--------..--..... 79 NGGQ........PVFMYEIAKGHSK.KSFGIHVAKLAG.FPLSVVSR.AQQILHQF..EG..... 80 QGQD........IVFLHQIQPGPAG.KSYGIAVAKLAG.LPVRALKS.AQKHLNGL..ENqaa32 81 QGQD........IVFLHQIQPGPAG.KSYGIAVAKLAG.LPVRALKS.AQKHLNGL..ENqaa32 82 HNNT........IAFMHAVQNGAAS.KSYGLAVAALAG.VPQSVIKL.AKQKLTQL..EKnss23 83 HGDT........IAFMHSVQDGAAS.KSYGLAVAALAG.VPKEVIKR.ARQKLREL..ESisp18 84 HGDT........IAFMHSVQDGAAS.KSYGLAVAALAG.VPKEVIKR.ARQKLREL..ESisp18 85 HGDT........IAFMHSVQDGAAS.KSYGLAVAALAG.VPKEVIKR.ARQKLREL..ESisp18 86 HGDT........IAFMHSVQDGAAS.KSYGLAVAALAG.VPKEVIKR.ARQKLREL..ESisp18 87 HGDT........IAFMHSVQDGAAS.KSYGLAVAALAG.VPKEVIKR.ARQKLREL..ESisp18 88 HNER........IVFLHHVLPGPAS.QSYGLAVAQLAG.VPGPVISR.AREHLARL..EAtsl22 89 HNER........IVFLHHVLPGPAS.QSYGLAVAQLAG.VPAPVIQR.AREHLKRL..ETtsl22 90 HNER........IVFLHHVLPGPAS.QSYGLAVAQLAG.VPTPVIQR.AREHLKRL..ETtsl22 91 HNER........IVFLHHVLPGPAS.QSYGLAVAQLAG.VPTAVIQR.AREHLGRL..ETtsl24 92 HNER........IVFLHHVLPGPAS.QSYGLAVAQLAG.VPTAVIQR.AREHLGRL..ETasl24 93 ----........-------------.------------.--------.--------..--..... 94 ----........-------------.------------.--------.--------..--..... 95 ----........-------------.------------.--------.--------..--..... 96 ----........-------------.------------.--------.--------..--..... 97 ----........-------------.------------.--------.--------..--..... 98 ----........-------------.------------.--------.--------..--..... 99 YKGE........LIFLHKVKDGAVD.DSYGIQVAKLAD.LPEKVISR.AQVILSEF..EAsag15 100 WDGD........VIFLHEVGPGAAD.RSYGIQVARLAG.LPASVVAR.ARDVLAKL..EDadr27 101 WDGD........VIFLHEVGPGAAD.RSYGIQVARLAG.LPASVVAR.ARDVLAKL..EDadr27 102 HSER........LVFMHTVKDGPAN.RSFGLQVAALAG.LPAAAVAH.ARRRLAEL..EQrgr22 103 ----........-------------.------------.--------.--------..--..... 104 ----........-------------.------------.--------.--------..--..... 105 ----........-------------.------------.--------.--------..--..... 106 YNGT........VVFLHQIKEGAAD.KSYGIHVAQLAE.LPGDLIAR.AQDILKEL..EH..... 107 YNGT........VVFLHQIKEGAAD.KSYGIHVAQLAE.LPGDLIAR.AQDILKEL..EH..... 108 QDGQ........VTFLHKIEPGPAD.KSYGIHVAKIAG.LPADLLAR.ADKILTQL..EN..... 109 TDEG........IRFLYILKEGRAK.GSFGIDVAKLAG.LPEEVVRE.AKKILKEL..EG..... 110 TPEG........IRFLYILKEGKAE.GSFGIEVAKLAG.LPEEVVEE.ARKILREL..EE..... 111 EGKN........VIFTHKVVDGVAD.RSYGIEVAKIAG.IPDRVINR.AYEILE--..--..... 112 EGKN........VIFTHKVVDGVAD.RSYGIEVAKIAG.IPDRVINR.AYEILE--..--..... 113 SGKD........ILFLHNIILGASN.KSYGLHVAALAG.LPTSVINR.AAQILLKF..EKisi24 114 DDED........ITLLYKVEPGISD.QSFGIHVAEVVQ.FPEKIVKM.AKRKANEL..DD..... 115 DDED........ITLLYKVEPGISD.QSFGIHVAEVVQ.FPEKIVKM.AKRKANEL..DD..... 116 TEDTl.......ITMLYRIKKGVCD.QSFGIHVAELAN.FPKHVIET.AKEKALEL..EE..... 117 TEET........LTMLYQVKTGVCD.QSFGIHVAELAN.FPRHVIEC.AKQKALEL..EE..... 118 TEET........LTMLYQVKKGVCD.QSFGIHVAELAN.FPRHVIAC.AKQKALEL..EE..... 119 TEET........LTMLYQVKKGVCD.QSFGIHVAELAN.FPRHVIAC.AKQKALEL..EE..... 120 ----........-------------.------------.--------.--------..--..... 121 TEET........LTMLYQVKKGVCD.QSFGIHVAELAN.FPKHVIEC.AKQKALEL..EE..... 122 ----........-------------.------------.--------.--------..--..... 123 ----........-------------.------------.--------.--------..--..... 124 TEET........LTMLYQVKKGVCD.QSFGIHVAELAN.FPKHVIEC.AKQKALEL..EE..... 125 ----........-------------.------------.--------.--------..--..... 126 ----........-------------.------------.--------.--------..--..... 127 SGTDtdt18kreVTLLYKVEPGICD.QSFGIHVAELVR.FPDKVVRM.AKRKADEL..ED..... 128 GDSEskd.....VALLYNVCEGASD.RSFGIHVAKLAH.FPPKIIEM.ASNKAAEL..EA..... 129 GDSEskd.....VALLYNVCEGASD.RSFGIHVAKLAH.FPPKIIEM.ASNKAAEL..EA..... 130 ----........-------------.------------.--------.--------..--..... 131 DPLSrk......LTMLYKVEPGACD.QSFGIHVAEFAN.FPEAVVAL.AKSKAAEL..ED..... 132 ----........-------------.------------.--------.--------..--..... 133 DTESrk......LTMLYKVEPGACD.QSFGIHVAEFAN.FPESVVAL.AREKAAEL..ED..... 134 DTESrk......LTMLYKVEPGACD.QSFGIHVAEFAN.FPESVVAL.AREKAAEL..ED..... 135 DADD........FTLLYQVRSGVME.KSFGIQVARLAN.FPEHVVQN.AQEVYNEF..ED..... 136 DADD........FTLLYQVRSGVME.KSFGIQVARLAN.FPEHVVQN.AQEVYNEF..ED..... 137 DADD........FTLLYQVRPGVME.KSFGIQVARLAN.FPEHVVQN.AQEVYNEF..ED..... 138 EAGGk.......IKYLFRMTPGLVD.CSFALSVAKEEG.IPPPVIGR.ACRIYKAL..KAg.... 139 EAGGk.......IKYLFRMTPGLVD.CSFALSVAKEEG.IPPPVIGR.ACRIYKAL..KAg.... 140 EAGGk.......IKYLFRMTPGLVD.CSFALSVAKEEG.IPPPVIGR.ACRIYKAL..KAg.... 141 ----........-------------.------------.--------.--------..--..... 142 DGED........LVFFYQLCQGVAS.ASHASHTAAQAG.LPDPLIAR.GKEVSDLI..RS..... 143 DGED........LVFFYQLCQGVAS.ASHASHTAAQAG.LPDPLIAR.GKEVSDLI..RS..... 144 DGND........LVFFYQVCEGVAK.ASHASHTAAQAG.LPDKLVAR.GKEVSDLI..RS..... 145 DGND........LVFFYQVCEGVAK.ASHASHTAAQAG.LPDKLVAR.GKEVSDLI..RS..... 146 ----........-------------.------------.--------.--------..--..... 147 DGND........LVFFYQVCEGVAK.ASHASHTAAQAG.LLDKLVAR.GKEVSDLI..RS..... 148 ESEG........ITFLFKVKEGISK.QSFGIYCAKVCG.LSRDIVER.AEELSR-M..IN..... 149 ESEG........ITFLFKVKEGISK.QSFGIYCAKVCG.LSPDIVER.AEELSR-M..IN..... 150 QENSa.......LIYERKLKPGPGP.SQYGIEV-----.--------.--------..--..... 151 QENSa.......LIYERKLKPGPGP.SQYGIEV-----.--------.--------..--..... 770 780 790 800 810 | | | | | 1 ...K..LV..IDSKKKKEL----------------------------------- 2 ...R..EG..NSCLEFLPHVSSDGNDKEILKNDTDIHIKLNE------------ 3 ...-..--..-------------------------------------------- 4 ...-..--..-------------------------------------------- 5 ...-..--..-------------------------------------------- 6 ...-..--..-------------------------------------------- 7 ...-..--..-------------------------------------------- 8 ...I..VY..GRILEKFQKTD--------------------------------- 9 ...E..--..-------------------------------------------- 10 ...-..--..-------------------------------------------- 11 ...D..VE..RKGSLFQSLMEERNKLKLQATKTAAFHRDLMNLYHELEHES--- 12 ...L..ME..RMLSELERERRELGEQLETAAAARR------------------- 13 ...E..IN..EVILDMERYKQEYQRLLNESRVYIRLSRELHENLLTA------- 14 ...D..IN..QVIAGLESQRREQEQKAANAQKLLQE------------------ 15 ...E..VD..TMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQI------ 16 ...E..IN..EMIESLERNYKRVETQRLELDRLVKEAEQVHD------------ 17 ...E..LE..GLIRSLHEKISLLEEEKRKLQKEREEYMKLREKYE--------- 18 ...Q..YI..KAMEKLSDYVKKYEEEFRKLEELRKELQKEKEEVEKLRKE---- 19 ...E..IN..EILEKLIEKEKD-------------------------------- 20 ...K..LN..VLIENSSALERELKQKNEHLENALKEQEYLKNA----------- 21 ...K..LN..VLIENSSTLERELKQKNEHLENALKEQEDLKNAW---------- 22 ...N..LE..ELVGKNINLELELKAKLENVEKKEQKVDEIL------------- 23 ...N..LE..ELVGKNINLELELKAKLENVEKKEQKVDEIL------------- 24 ...-..--..-------------------------------------------- 25 ...-..--..-------------------------------------------- 26 ...R..KP..VHGDKELKLLSRRRKLVLELYFALNYI----------------- 27 ...Q..IL..QNQRSTPEME---------------------------------- 28 ...Q..IL..QNQRSTPEME---------------------------------- 29 ...N..VE..DTERDYDSERRRIK------------------------------ 30 ...EsiNE..DALKLFSSLKRILKSDNITATDKLA------------------- 31 ...EsiNE..DALKLFSSLKRILKSDNITATDKLA------------------- 32 ...E..VR..ARERNTRMGEPEGHEEPRGAEESISALGDLF------------- 33 ...E..VR..ARERNTRMGEPEGHEEPRGAEESISALGDLF------------- 34 ...E..VR..ARERNTRMGEPEGHEEPRGAEESISALGDLF------------- 35 ...L..V-..-------------------------------------------- 36 ...-..--..-------------------------------------------- 37 ...-..--..-------------------------------------------- 38 ...L..V-..-------------------------------------------- 39 ...L..V-..-------------------------------------------- 40 ...L..IN..TK------------------------------------------ 41 ...L..IN..TK------------------------------------------ 42 ...-..--..-------------------------------------------- 43 ...K..HR..NAR----------------------------------------- 44 ...I..ID..PKIRHLVECARDDNFDVGEL------------------------ 45 ...-..--..-------------------------------------------- 46 ...-..MN..QSLRLFREVCLASERSTVDAEAVHKLL----------------- 47 ...-..--..-------------------------------------------- 48 ...-..MN..QSLRLFREVCLASERSTVDAEAVHKLL----------------- 49 ...-..MN..QSLRLFREVCLASERSTVDAEAVHKLL----------------- 50 ...-..MN..QSLRLFREVCLASERSTVDAEAVHKLL----------------- 51 ...-..MN..QSLQLFREVCLATEKPTINGEAIHR------------------- 52 ...-..MN..QSLRLFRGVCLATEKPTINGEAIHR------------------- 53 ...K..IA..GNFKS--------------------------------------- 54 ...K..IA..GNFKS--------------------------------------- 55 ...-..--..-------------------------------------------- 56 ...S..IG..ENFK---------------------------------------- 57 ...-..--..-------------------------------------------- 58 ...-..--..-------------------------------------------- 59 ...N..YG..KRHKMTNDKHVSAQ------------------------------ 60 ...L..YG..KNHRKTDH------------------------------------ 61 ...L..YG..KNHRKTDH------------------------------------ 62 ...A..SA..SFINASDDI--ALMSDF--------------------------- 63 ...-..--..-------------------------------------------- 64 ...-..--..-------------------------------------------- 65 ...R..AG..S------------------------------------------- 66 ...R..RE..GALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG 67 ...R..RE..GALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMK- 68 ...R..RE..GALEEVLERLLALNPDRLTPLEALRFLHELKALALGLPLGSMK- 69 ...R..RE..GALEEVLERLLALNPDRLTPLEALRFLHELKALALGLPLGSMK- 70 ...R..RE..GALEEVLERLLALDPDRLTPLEALRFLHELKALALGLPLGSMK- 71 ...R..RE..GALEEVLERLLALDPDRLTPLEALRFLHELKALALGLPLGSMK- 72 ...H..--..-------------------------------------------- 73 ...H..--..-------------------------------------------- 74 ...-..--..-------------------------------------------- 75 ...-..--..-------------------------------------------- 76 ...-..--..-------------------------------------------- 77 ...-..--..-------------------------------------------- 78 ...-..--..-------------------------------------------- 79 ...-..--..-------------------------------------------- 80 dkaE..EK..HFEGILAAALEKLDPDSLTPREALSELYRLKDLC---------- 81 dkaE..EK..HFEGILAAALEKLDPDSLTPREALSELYRLKDLC---------- 82 gelF..FE..QETDALREAIEKLDPDDLSPKQALAYLYQLKK------------ 83 sllS..VP..EETSPAVEALENLDPDSLTPRQALEWIYRLK------------- 84 sllS..VP..EETSPAVEALENLDPDSLTPRQALEWIYRLK------------- 85 sllS..VP..EETSPAVEALENLDPDSLTPRQALEWIYRLK------------- 86 sllA..AP..EETSPAVEALENLDPDSLTPRQALEWIYRLK------------- 87 sllA..AP..EETSPAVEALENLDPDSLTPRQALEWIYRLK------------- 88 qsdL..FA..SLPHPLMEELARLKPDDLSPRQALELLYSW-------------- 89 qsdL..FA..SLPHPVIDELSRINPDDISPRQALDLLYA--------------- 90 qsdL..FA..SLPHPVIDELSRINPDDISPRQALDLLYA--------------- 91 qsdL..FA..SLPHPAIEKLGKLQLDDMTPRQAIEMLYQLK------------- 92 qsdL..FA..SLPHPAIEKLGKLDLDDMTPRQAIEMLYQLK------------- 93 ...-..--..-------------------------------------------- 94 ...-..--..-------------------------------------------- 95 ...-..--..-------------------------------------------- 96 ...-..--..-------------------------------------------- 97 ...-..--..-------------------------------------------- 98 ...-..--..-------------------------------------------- 99 mveN..EP..EINQE--------------------------------------- 100 eaaR..AS..SGPSKVEEALKALNPDDMTPREALDALYALK------------- 101 eaaR..AS..SGPSKVEEALKALNPDDMTPREALDALYALK------------- 102 qcsL..FA..SAPSAAQEALVALHPDELTPKQALEALYRLK------------- 103 ...-..--..-------------------------------------------- 104 ...-..--..-------------------------------------------- 105 ...-..--..-------------------------------------------- 106 ...S..GN..KPEVPVQKPQVKEEPAQLSFFDEAEKPAE--------------- 107 ...S..GN..KPEVPVQKPQVKEEPAQLSFFDEAEKPAE--------------- 108 ...Q..GT..ESPPP--------------------------------------- 109 ...Ek.GK..QEVLPFLEETYKKSVDEEKLNFYEEIIKEIE------------- 110 ...K..ENkkEDIVPLLEETFKKSEEAQRLEEYEEIIKKIEE------------ 111 ...-..--..-------------------------------------------- 112 ...-..--..-------------------------------------------- 113 fehE..KP..ISNSKLDEEFKTIDPDKISPKEALELIYKFK------------- 114 ...-..--..-----LKTNNEDLKKAKLSLQEVNEGNIRLKALLKEWIRKVK-- 115 ...-..--..-----LKTNNEDLKKAKLSLQEVNEGNIRLKALLKEWIRKVK-- 116 ...F..QY..VGNPDDCDDEPARKRRCEEKEEGEKIIQDFLSRVKALPLTEM-- 117 ...Fq.SI..GTSQGHDETQPAAKRRCLEREQGEKIILEFLSKVKQVPFT---- 118 ...F..QNi.GTSLGCDEAEPAAKRRCLEREQGEKIILEFLSKVKQVPFTAM-- 119 ...F..QNi.GTSLGCDEAEPAAKRRCLEREQGEKIILEFLSKVKQVPFTAM-- 120 ...-..--..-------------------------------------------- 121 ...F..QY..-------------------------------------------- 122 ...-..--..-------------------------------------------- 123 ...-..--..-------------------------------------------- 124 ...Fq.YI..GESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPFTEM-- 125 ...-..--..-------------------------------------------- 126 ...-..--..-------------------------------------------- 127 ...F..TS..KHEEEN-------------------------------------- 128 ...E..DS..GAQGDTQEVKSKKE------------------------------ 129 ...E..DS..GAQGDTQEVKSKKE------------------------------ 130 ...-..--..-------------------------------------------- 131 ...FstTP..TFSDDLKDEVGSKRKRVFSPDDITRGAARARLFLEEFA------ 132 ...-..--..-------------------------------------------- 133 ...F..SP..SSMIINNEESGKRKSREDDPDEVSRGAERAHKFLKEF------- 134 ...F..SP..SSMIINNEESGKRKSREDDPDEVSRGAERAHKFLKEF------- 135 ...E..HV..DKQKKEDKAL---------------------------------- 136 ...E..HV..DKQKKEDKAL---------------------------------- 137 ...E..HV..DKQKKEDKAL---------------------------------- 138 ...-..--..-------------------------------------------- 139 ...-..--..-------------------------------------------- 140 ...-..--..-------------------------------------------- 141 ...-..--..-------------------------------------------- 142 ...-..--..-------------------------------------------- 143 ...-..--..-------------------------------------------- 144 ...-..--..-------------------------------------------- 145 ...-..--..-------------------------------------------- 146 ...-..--..-------------------------------------------- 147 ...-..--..-------------------------------------------- 148 ...R..GD..DVVQQCGNLTEKEMREFQKNQEIVKKFLS--------------- 149 ...R..GD..DVVQQCGNLTEKEMREFQKNQEIVKKFLS--------------- 150 ...-..--..-------------------------------------------- 151 ...-..--..--------------------------------------------