; SAM: prettyalign v3.2 (June, 2000) compiled 07/10/00_09:40:44 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequence numbers correspond to the following labels: ; 1 T0116 ; 2 gi|2497995|sp|Q56215|MUTS_THEAQ_3:810 ; 3 gi|1871501|dbj|BAA09880.1|_11:818 ; 4 gi|2497996|sp|Q56239|MUTS_THETH_11:818 ; 5 gi|2145507|pir||S62790_18:817 ; 6 gi|7387928|sp|Q9ZIX6|MUTS_THECA_9:816 ; 7 gi|4887554|emb|CAB43497.1|_6:850 ; 8 gi|1592569|gb|AAB97931.1|_6:850 ; 9 gi|127555|sp|P27345|MUTS_AZOVI_3:851 ; 10 gi|127556|sp|P23909|MUTS_ECOLI_6:850 ; 11 gi|1171081|sp|P44834|MUTS_HAEIN_3:858 ; 12 gi|7108493|gb|AAF36440.1|AF126491_1_3:850 ; 13 gi|7229490|gb|AAF42850.1|_3:851 ; 14 gi|6678938|ref|NP_032654.1|_18:899 ; 15 gi|417330|sp|P10339|MUTS_SALTY_6:851 ; 16 gi|726086|gb|AAA75027.1|_18:899 ; 17 gi|4557761|ref|NP_000242.1|_18:899 ; 18 gi|2135744|pir||I37550_18:856 ; 19 gi|6754744|ref|NP_034960.1|_393:1350 ; 20 gi|79102|pir||A28668_6:850 ; 21 gi|2506881|sp|P54276|MSH6_MOUSE_393:1350 ; 22 gi|1709123|sp|P52701|MSH6_HUMAN_394:1354 ; 23 gi|1082386|pir||A56742_326:1286 ; 24 gi|4504191|ref|NP_000170.1|_394:1354 ; 25 gi|7512474|pir||JC5839_394:1354 ; 26 gi|1709122|sp|P54275|MSH2_RAT_18:897 ; 27 gi|1079288|pir||S53609_16:898 ; 28 gi|123080|sp|P10564|HEXA_STRPN_4:794 ; 29 gi|7448108|pir||S74860_52:875 ; 30 gi|7404403|sp|P49849|MUTS_BACSU_3:818 ; 31 gi|7404405|sp|P73769|MUTS_SYNY3_18:841 ; 32 gi|7190210|gb|AAF39048.1|_3:804 ; 33 gi|7379009|emb|CAB83555.1|_4:860 ; 34 gi|1002520|gb|AAB19235.1|_2:812 ; 35 gi|387849|gb|AAB60711.1|_175:1051 ; 36 gi|4505249|ref|NP_002430.1|_211:1091 ; 37 gi|6647605|sp|Q9ZDM9|MUTS_RICPR_12:888 ; 38 gi|400971|sp|P13705|MSH3_MOUSE_175:1051 ; 39 gi|9106782|gb|AAF84525.1|AE003995_7_39:900 ; 40 gi|1083296|pir||JC4019_189:1086 ; 41 gi|118951|sp|P20585|MSH3_HUMAN_220:1100 ; 42 gi|7227419|gb|AAF42468.1|_4:860 ; 43 gi|6226653|sp|P74926|MUTS_THEMA_3:768 ; 44 gi|7387913|sp|O84797|MUTS_CHLTR_4:804 ; 45 gi|7189834|gb|AAF38705.1|_4:810 ; 46 gi|8473172|sp|P56883|MUTS_RHIME_20:910 ; 47 gi|7387924|sp|Q9Z6W5|MUTS_CHLPN_4:810 ; 48 gi|3024198|sp|P70755|MUTS_AQUPY_5:826 ; 49 gi|1619909|gb|AAB16999.1|_3:768 ; 50 gi|6093453|sp|O83348|MUTS_TREPA_4:812 ; 51 gi|1174416|sp|P43248|MSH2_DROME_8:860 ; 52 gi|135075|sp|P26359|SWI4_SCHPO_94:958 ; 53 gi|3914079|sp|O66652|MUTS_AQUAE_4:828 ; 54 gi|1076927|pir||S22569_4:856 ; 55 gi|7448104|pir||I64827_18:787 ; 56 gi|7492209|pir||T41262_362:1228 ; 57 gi|6226648|sp|O04716|MSH6_ARATH_367:1283 ; 58 gi|3914056|sp|O24617|MSH2_ARATH_26:899 ; 59 gi|4139230|gb|AAD04176.1|_26:899 ; 60 gi|7287834|gb|AAF44872.1|AE003406_77_17:888 ; 61 gi|3914075|sp|O51737|MUTS_BORBU_4:825 ; 62 gi|2104549|gb|AAB57798.1|_384:1321 ; 63 gi|3319876|emb|CAA07684.1|_94:1044 ; 64 gi|7298155|gb|AAF53392.1|_17:801 ; 65 gi|4775576|emb|CAB42554.1|_29:905 ; 66 gi|6320302|ref|NP_010382.1|_299:1168 ; 67 gi|6319935|ref|NP_010016.1|_152:1039 ; 68 gi|1588283|prf||2208298A_299:1168 ; 69 gi|3914053|sp|O13396|MSH2_NEUCR_7:870 ; 70 gi|172000|gb|AAA34801.1|_69:957 ; 71 gi|6166561|sp|O13921|MSH1_SCHPO_49:928 ; 72 gi|448278|prf||1916402A_152:1038 ; 73 gi|6321912|ref|NP_011988.1|_69:957 ; 74 gi|4151103|emb|CAA07342.1|_20:925 ; 75 gi|7331984|gb|AAF60672.1|_840:1781 ; 76 gi|6324482|ref|NP_014551.1|_9:918 ; 77 gi|172002|gb|AAA34802.1|_9:918 ; 78 gi|4775580|emb|CAB42556.1|_46:825 ; 79 gi|4775578|emb|CAB42555.1|_353:1132 ; 80 gi|7269404|emb|CAB81364.1|_94:1039 ; 81 gi|3914062|sp|O65607|MSH3_ARATH_94:1039 ; 82 gi|6224917|gb|AAF06013.1|AF193018_1_255:1054 ; 83 gi|4505253|ref|NP_002432.1|_46:780 ; 84 gi|3108220|gb|AAC62533.1|_46:780 ; 85 gi|5725250|emb|CAB52406.1|_46:797 ; 86 gi|3886083|gb|AAC78226.1|_17:834 ; 87 gi|110917|pir||A32495_175:918 ; 88 gi|7522430|pir||T38256_2:767 ; 89 gi|3831701|gb|AAC70065.1|_89:829 ; 90 gi|8515837|gb|AAF76200.1|_89:829 ; 91 gi|3986757|gb|AAC84154.1|_15:779 ; 92 gi|7305281|ref|NP_038628.1|_15:779 ; 93 gi|4336728|gb|AAD17920.1|_148:883 ; 94 gi|4505251|ref|NP_002431.1|_148:883 ; 95 gi|3914066|sp|Q19272|MSH5_CAEEL_89:930 ; 96 gi|7012942|gb|AAF35250.1|AF227632_1_1:589 ; 97 gi|7243293|dbj|BAA92687.1|_42:560 ; 98 gi|730066|sp|P40965|MSH4_YEAST_97:813 ; 99 gi|6321109|ref|NP_011187.1|_97:815 ; 100 gi|5815430|gb|AAD52669.1|AF178755_1_43:788 ; 101 gi|7493777|pir||T18246_42:771 ; 102 gi|2147739|pir||S58881_17:857 ; 103 gi|1582703|prf||2119252A_97:878 ; 104 gi|6320047|ref|NP_010127.1|_97:878 ; 105 gi|3914061|sp|O63852|MSHM_SARGL_17:857 ; 106 gi|7512473|pir||JC5840_394:1057 ; 107 gi|7294307|gb|AAF49656.1|_249:980 ; 108 gi|3914084|sp|P94545|MUS2_BACSU_18:558 ; 109 gi|3914080|sp|O67287|MUS2_AQUAE_35:554 ; 110 gi|7328295|emb|CAB82462.1|_3:360 ; 111 gi|7387923|sp|Q9X105|MUS2_THEMA_21:541 ; 112 gi|7490470|pir||T39976_7:377 ; 113 gi|1000883|gb|AAB59571.1|_18:528 ; 114 gi|3914083|sp|P73625|MUS2_SYNY3_53:577 ; 115 gi|7473468|pir||A75332_6:536 ; 116 gi|3914057|sp|O25338|MUS2_HELPY_45:550 ; 117 gi|7387931|sp|Q9ZLL4|MUS2_HELPJ_45:551 ; 118 gi|7188744|gb|AAF37851.1|AF227730_1_3:345 ; 119 gi|7387927|sp|Q9ZEH5|MUS2_STAAU_20:490 ; 120 gi|7328284|emb|CAB82466.1|_2:419 ; 121 gi|3914072|sp|O51125|MUS2_BORBU_40:531 ; 122 gi|1000879|gb|AAB59570.1|_18:482 ; 123 gi|6227005|gb|AAF06041.1|AC009360_6_110:630 ; 124 gi|6968488|emb|CAB73308.1|_30:527 ; 125 gi|8572747|gb|AAF77187.1|AF264911_3_30:527 ; 126 gi|1000877|gb|AAB59569.1|_18:423 ; 127 gi|7522263|pir||T39832_20:579 ; 128 gi|8809580|dbj|BAA97131.1|_143:663 ; 129 gi|5814102|gb|AAD52100.1|_4:247 ; 130 gi|7512546|pir||T34526_2:248 ; 131 gi|1000875|gb|AAB59568.1|_18:377 ; 132 gi|5305132|emb|CAB46193.1|_1:218 ; 133 gi|7514768|pir||A75007_73:551 ; 134 gi|7518647|pir||C71155_57:549 ; 135 gi|4099512|gb|AAD00647.1|_1:117 ; 136 gi|7448107|pir||T08098_1:116 ; 137 gi|4100661|gb|AAD00921.1|_6:129 ; 138 gi|8052216|emb|CAB92351.1|_6:128 ; 139 gi|7482290|pir||C69102_169:642 ; 140 gi|6473463|dbj|BAA87137.1|_2:169 ; 141 gi|4587694|gb|AAD25860.1|_1:99 ; 142 gi|4587688|gb|AAD25857.1|_1:99 ; 143 gi|4587708|gb|AAD25867.1|_1:99 ; 144 gi|4587710|gb|AAD25868.1|_1:99 ; 145 gi|4587700|gb|AAD25863.1|_1:99 ; 146 gi|4587702|gb|AAD25864.1|_1:99 ; 147 gi|4587698|gb|AAD25862.1|_1:99 ; 148 gi|6981224|ref|NP_034959.1|_143:374 ; 149 gi|4165574|emb|CAA10614.1|_1:90 ; 150 gi|2522394|gb|AAB82654.1|_1:86 ; 151 gi|7547005|gb|AAF63754.1|AF242852_1_65:255 10 20 30 40 50 | | | | | 1 MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFG.E........DAERLARALGL 2 --GMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFG.E........DAERLARALGL 3 --GMLKGEGPGPLPPLLQQYVELRDRYPDYLLLFQVGDFYECFG.E........DAERLARALGL 4 --GMLKGEGPGPLPPLLQQYVELRDRYPDYLLLFQVGDFYECFG.E........DAERLARALGL 5 ----------PPLPPLLQQYVELRDRYPDYLLLFQVGDFYECFG.E........DAERLARALGL 6 ---MLKGEGPGPLPPLLQQYVELRDRYPDYLLLFQVGDFYECFG.E........DAERLARALGL 7 --------NFDAHTPMMQQYLKLKAQHPEILLFYRMGDFYELFY.D........DAKRASQLLDI 8 --------NFDAHTPMMQQYLKLKAQHPEILLFYRMGDFYELFY.D........DAKRASQLLDI 9 --------SLSQHTPMMQQYWKLKREHPDQLMFYRMGDFYELFY.E........DAKKAAKLLDI 10 --------NFDAHTPMMQQYLRLKAQHPEILLFYRMGDFYELFY.D........DAKRASQLLDI 11 -----SEENFQQHTPMMQQYLKLKAENPDILLFYRMGDFYELFY.D........DAKKAAALLDI 12 --------DLSQHTPMMQQYFKLKHQHPDQLMFYRMGDFYELFY.E........DAKKAAKLLDI 13 --------DLSQHTPMMQQYFKLKHQHPDQLMFYRMGDFYELFY.E........DAKKAAKLLDI 14 --------------GFVRFFEGMPEKPSTTVRLFDRGDFYTAHG.E........DALLAAREVFK 15 ------DKDFSNHTPMMQQYLKLKAQHPEILLFYRMGDFYELFY.D........DAKRASQLLDI 16 --------------GFVRFFEGMPEKPSTTVRLFDRGDFYTAHG.E........DALLAAREVFK 17 --------------GFVRFFQGMPEKPTTTVRLFDRGDFYTAHG.E........DALLAAREVFK 18 --------------GFVRFFQGMPEKPTTTVRLFDRGDFYTAHG.E........DALLAAREVFK 19 TTLYVPEEFLNSCTPGMRKWWQLKSQNFDLVIFYKVGKFYELYH.M........DAVIGVSELGL 20 ------DKDFSNHTPMMQQYLKLKAQHPEILLFYRMGDFYELFY.D........DAKRASQLLDI 21 TTLYVPEEFLNSCTPGMRKWWQLKSQNFDLVIFYKVGKFYELYH.M........DAVIGVSELGL 22 STLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYH.M........DALIGVSELGL 23 STLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYH.M........DALIGVSELGL 24 STLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYH.M........DALIGVSELGL 25 STLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYH.M........DALIGVSELGL 26 --------------GFVRFFEGMPEKPSTTVGLFDRGDFYTAHG.E........DALLAAREVFK 27 ------------ENGFLHFYQSMPEKPDTTVRVFDRNDYYTVHG.G........DALFAAKEVFK 28 ----------EKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFY.E........DAVNAAQILEI 29 -----RTLDRQKLTPMFQHYTEVKEQYQGALLLYRVGDFFECFF.Q........DAVIIARELEL 30 -----------GYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFF.E........DAKKASQELEI 31 -----RTLDRQKLTPMFQHYTEVKEQYQGALLLYRVGDFFECFF.Q........DAVIIARELEL 32 ----------QKLTPMMQQWHQCKEQAGDCLLLFRLGEFYEAFF.D........DALVLAQNLDI 33 ----------SAVSPMMQQYLGIKAQHTDKLVFYRMGDFYEMFF.D........DAVEAAKLLDI 34 ----------------IQQYLKIKAEHQDAFLFFRLGDFYEMFF.E........DAKKASQELEI 35 DCKPFNKRSKSVYTPLELQYLDMKQQHKDAVLCVECGYKYRFFG.E........DAEIAARELNI 36 ---SANKRSKSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFG.E........DAEIAARELNI 37 ----RQKYNYNVATKMMQQYLDIKFAHLDCLLLFRMGDFYELFY.E........DAILASNILGI 38 DCKPFNKRSKSVYTPLELQYLDMKQQHKDAVLCVECGYKYRFFG.E........DAEIAARELNI 39 --KPEGGKGMAEHTPLMKQYFAAKAEYPDLLLFFRMGDFYELFH.Q........DARKAARLLDI 40 DCKPFNKRSKSVYTPLELQYLDMKQQHKDAVLCVECGYKYRFFG.E........DAEIAARELNI 41 ---SANKRSKSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFG.E........DAEIAARELNI 42 ----------SAVSPMMQQYLGIKAQHTDKLVFYRMGDFYEMFF.D........DAVEAAKLLDI 43 ------------VTPLMEQYLRIKEQYKDSILLFRLGDFYEAFF.E........DAKIVSKVLNI 44 -----------KLTPMMQQWHQCKEQAGDCLLLFRLGEFYEAFF.D........DALILAQNLDI 45 ----------KKPTPMMEQWHQCKEKAGDSVLLFRMGDFYEAFY.D........DAVLLSQHLEL 46 ---LASEESRSTATPMMEQFIEIKANNPDSLLFYRMGDFYELFF.Q........DAVEASRALGI 47 ----------KKPTPMMEQWHQCKEKAGDSVLLFRMGDFYEAFY.D........DAVLLSQHLEL 48 ---------EKELTPMLAQYHQFKSMYPDCLLLFRLGDFYELFY.E........DAVVGSKELGL 49 ------------VTPLMEQYLRIKEQYKDSILLFRLGDFYEAFF.E........DAKIVSKVLNI 50 ---------LASDTPLMRQYHAIRAQHPDAVLFFRLGDFYEMFD.S........DALHVSTLLGL 51 ---TYPEYGHKCASNFIKFHAKLGEKPATTVRFFDHTDRYTVHGsD........DCELVAKIVYK 52 ---SKPTKQKSVFTPLEQQYLELKKNYQETILAIEVGYKFRFFG.K........DAKIASEVLGI 53 --------SEKELTPMLSQYHYFKNQYPDCLLLFRLGDFYELFY.E........DAYIGSKELGL 54 -----PTKQKSVFTPLEQQYLELKKNYQETILAIEVGYKFRFFG.K........DAKIASEVLGI 55 --------------GFVRFFQGMPEKPTTTVRLFDRGDFYTAHG.E........DALLAAREVFK 56 RTLYIPPSAWATFKPFEKQFWKIKKDLMDTVVFFQKGKFYELYE.N........DAAIGHQVFSL 57 RTLYLPPDFVKKLTGGQRQWWEFKAKHMDKVVFFKMGKFYELFE.M........DAHVGAKELDI 58 ------------------SFYKTLPNDTRAVRFFDRKDYYTAHG.E........NSVFIAKTYYH 59 ------------------SFYKTLPNDTRAVRFFDRKDYYTAHG.E........NSVFIAKTYYH 60 --------DTNARRNFIKFHAKLGEKPATTVRFFDHTDRYTVHGsD........DCELVAKIVYK 61 -----------NVTPMIRQYLDIKKKYKDAVLFFRVGSFYEMFF.D........DAIEVSKLLNL 62 ----LTGGQVRRAHGNLRQWWEFKAKHMDKVVFFKMGKFYELFE.M........DAHVGAKELDI 63 --YVPETSSSRKYTPLEQQVVELKSKYPDVVLMVEVGYRYRFFG.E........DAEIAARVLGI 64 --------DTNARRNFIKFHAKLGEKPATTVRFFDHTDRYTVHGsD........DCELVAKIVYK 65 -------------------FFKKLPQDPRAVRLFDRRDYYTAHG.E........NATFIARTYYH 66 RTLYIPSSAWNKFTPFEKQYWEIKSKMWDCIVFFKKGKFFELYE.K........DALLANALFDL 67 ---KARKSPTAKLTPLDKQVKDLKMHHRDKVLVIRVGYKYKCFA.E........DAVTVSRILHI 68 RTLYIPSSAWNKFTPFEKQYWEIKSKMWDCIVFFKKGKEFELYE.K........DALLANALFDL 69 -------LKVDDEHGFIRFYKSLPQLGEEAIRIFDRGDWYTAHG.D........DATFIARTVYK 70 --LSSTEPSKASLPPSLQYVRDLMDLYKDHVVLTQMGSFYELYF.E........QAIRYAPELNI 71 -LDFIRPKEKVTLPPLLKEVSFQQKKFADCVLLTKVGNFYEMYF.E........QAEKIGPLLNL 72 ---KARKSPTAKLTPLDKQVKDLKMHHRDKVLVIRVGYKY-CFA.E........DAVTVSRILHI 73 --LSSTEPSKASLPPSLQYVRDLMDLYKDHVVLTQMGSFYELYF.E........QAIRYAPELNI 74 ------------------NFYEKMPKDTNTVRVFDRGEFYVAIG.E........DASFVAQNAYH 75 KTLWVPPDFHQKQTPGHRQWWTMKSQHFDTILLFKVGKFYETYH.M........DAVEVVRALNI 76 -----KFSDVSEERNFYKKYTGLPKKPLKTIRLVDKGDYYTVIG.S........DAIFVADSVYH 77 -----KFSDVSEERNFYKKYTGLPKKPLKTIRLVDKGDYYTVIG.S........DAIFVADSVYH 78 STLFIPPDALRKMSTSQKQYWNIKCKYMDVVLFFKVGKFYELYE.L........DAEIGQKELDW 79 STLFIPPDALRKMSTSQKQYWNIKCKYMDVVLFFKVGKFYELYE.L........DAEIGQKELDW 80 --YVPETSSSRKYTPLEQQVVELKSKYPDVVLMVEVGYRYRFFG.E........DAEIAARVLGI 81 --YVPETSSSRKYTPLEQQVVELKSKYPDVVLMVEVGYRYRFFG.E........DAEIAARVLGI 82 KTLHIPPDVFKKMSASQKQYWSVKSEYMDIVLFFKVGKFYELYE.L........DAELGHKELDW 83 --------------------------------------------.-........----------- 84 --------------------------------------------.-........----------- 85 --------------------------------------------.-........----------- 86 ----------------------LKSKSPNTIAIFSRGEYFSVYG.D........DATFVATNIFK 87 DCKPFNKRSKSVYTPLELQYLDMKQQHKDAVLCVECGYKYRFFG.E........DAEIAARELNI 88 --------------------------------------------.-........----------- 89 --------------------------------------------.-........----------- 90 --------------------------------------------.-........----------- 91 --------------------------------------------.-........----------- 92 --------------------------------------------.-........----------- 93 --------------------------------------------.-........----------- 94 --------------------------------------------.-........----------- 95 --------------------------------------------.-........----------- 96 --------------------------------------------.-........----------- 97 --------------------------------------------.-........----------- 98 --------------------------------------------.-........----------- 99 --------------------------------------------.-........----------- 100 --------------------------------------------.-........----------- 101 --------------------------------------------.-........----------- 102 -----------------------SKYGLSVIQLIQIGKFYELWH.Epdt17llvESSIRSRSLEV 103 --------------------------------------------.-........----------- 104 --------------------------------------------.-........----------- 105 -----------------------SKYGLSVIQLIQIGKFYELWH.Epdt17llvESSIRSRSLEV 106 STLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYH.M........DALIGVSELGL 107 STLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYH.M........DADVGVNELGF 108 --------------------------------------------.-........----------- 109 --------------------------------------------.-........----------- 110 --------------------------------------------.-........----------- 111 --------------------------------------------.-........----------- 112 --------------------------------------------.-........----------- 113 --------------GFVRFFQGMPEKPTTTVRLFDRGDFYTAHG.E........DALLAAREVFK 114 --------------------------------------------.-........----------- 115 --------------------------------------------.-........----------- 116 --------------------------------------------.-........----------- 117 --------------------------------------------.-........----------- 118 --------------------------------------------.-........----------- 119 --------------------------------------------.-........----------- 120 ----------SNVTPMMQQYLKIKSEYQDCLLFFRLGDFYEMFY.E........DAKEASRVLEI 121 --------------------------------------------.-........----------- 122 --------------GFVRFFQGMPEKPTTTVRLFDRGDFYTAHG.E........DALLAAREVFK 123 --------------------------------------------.-........----------- 124 --------------------------------------------.-........----------- 125 --------------------------------------------.-........----------- 126 --------------GFVRFFQGMPEKPTTTVRLFDRGDFYTAHG.E........DALLAAREVFK 127 ------------------NFYEKMPKDTNTVRVFDRGEFYVAIG.E........DASFVAQNAYH 128 --------------------------------------------.-........----------- 129 --------------------------------------------.-........----------- 130 --------------------------------------------.-........----------- 131 --------------GFVRFFQGMPEKPTTTVRLFDRGDFYTAHG.E........DALLAAREVFK 132 --------------------------------------------.-........----------- 133 --------------------------------------------.-........----------- 134 --------------------------------------------.-........----------- 135 --------------------------------------------.-........----------- 136 --------------------------------------------.-........----------- 137 --------------------------------------------.-........----------- 138 --------------------------------------------.-........----------- 139 --------------------------------------------.-........----------- 140 --------------------------------------------.-........----------- 141 --------------------------------------------.-........----------- 142 --------------------------------------------.-........----------- 143 --------------------------------------------.-........----------- 144 --------------------------------------------.-........----------- 145 --------------------------------------------.-........----------- 146 --------------------------------------------.-........----------- 147 --------------------------------------------.-........----------- 148 DCKPFNKRSKSVYTPLELQYLDMKQQHKDAVLCVECGYKYRFFG.E........DAEIAARELNI 149 --------------------------------------------.-........----------- 150 --------------------------------------------.-........----------- 151 -----------KYTPLEQQVVELKRKHPDVILMVEVGYRYRFFG.E........DAEIAARVLGI 60 70 80 90 100 | | | | | 1 VLTHKT........SKD....FTTPMAGIPLRAFEAYAERLL..KMGFRLAVADQVEPA...EEA 2 VLTHKT........SKD....FTTPMAGIPLRAFEAYAERLL..KMGFRLAVADQVEPA...EEA 3 VLTHKT........SKD....FTTPMAGIPIRAFDAYAERLL..KMGFRLAVADQVEPA...EEA 4 VLTHKT........SKD....FTTPMAGIPIRAFDAYAERLL..KMGFRLAVADQVEPA...EEA 5 VLTHKT........SKD....FTTPMAGIPIRAFDAYAERLL..KMGFRLAVADQVEPA...EEA 6 VLTHKT........SKD....FTTPMAGIPIRAFDAYAERLL..RMGFGLAVADQVEPA...EEA 7 SLTKRGa.......SAG....EPIPMAGIPYHAVENYLAKLV..NQGESVAICEQIGDP...ATS 8 SLTKRSa.......SAG....EPIPMAGIPYHAVENYLAKLV..NQGESVAICEQIGDP...ATS 9 TLTARGq.......SAG....KSIPMAGIPFHSVEGYLAKLV..KLGESVAICEQIGDP...ATT 10 SLTKRGa.......SAG....EPIPMAGIPYHAVENYLAKLV..NQGESVAICEQIGDP...ATS 11 SLTKRGq.......SAG....QPIPMAGMPYHAVEGYLAKLV..QLGESVAICEQIGDP...TTS 12 TLTARGq.......SGG....KAIPMAGIPFHSAEGYLAKLV..KLGESVAICEQIGDP...ATS 13 TLTARGq.......SGG....KAIPMAGIPFHSAEGYLAKLV..KLGESVAICEQIGDP...ATS 14 TQGVIKymgp....AGS....KTLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNKAGN...KAS 15 SLTKRGa.......SAG....EPIPMAGIPHHAVENYLAKLV..NQGESVAICEQIGDP...ATS 16 TQGVIKymgp....AGS....KTLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNKAGN...KAS 17 TQGVIK........YMGpagaKNLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNRAGN...KAS 18 TQGVIK........YMGpagaKNLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNRAGN...KAS 19 IF----........-MK....GNWAHSGFPEIAFGRFSDSLV..QKGYKVARVEQTETP...EMM 20 SLTKRGa.......SAG....EPIPMAGIPHHAVENYLAKLV..NQGESVAICEQIGDP...ATS 21 IF----........-MK....GNWAHSGFPEIAFGRFSDSLV..QKGYKVARVEQTETP...EMM 22 VF----........-MK....GNWAHSGFPEIAFGRYSDSLV..QKGYKVARVEQTETP...EMM 23 VF----........-MK....GNWAHSGFPEIAFGRYSDSLV..QKGYKVARVEQTETP...EMM 24 VF----........-MK....GNWAHSGFPEIAFGRYSDSLV..QKGYKVARVEQTETP...EMM 25 VF----........-MK....GNWAHSGFPEIAFGRYSDSLV..QKGYKVARVEQTETP...EMM 26 TQGVIK........YMGpagaKTLQTVVLSKMNFESFVKDLLl.VRHYRVEVYKNKAGN...KAS 27 TNGVIKylg.....SGN....KKLESVVLSKMNFESVVKDLLl.VRQYRVEVYKNKSGG...KYS 28 SLTSRNk.......NAD....NPIPMAGVPYHSAQQYIDVLI..EQGYKVAIAEQMEDP...KQA 29 ILTSKE........GGKei..GRVAMTGVPHHALDRYARQLV..EKGYAVAICDQVEDA...AEA 30 TLTSRDg.......GAA....EKIPMCGVPYHSASAYIEQLI..KKGYKVAICEQTEDP...KAA 31 ILTSKE........GGKei..GRVAMTGVPHHALDRYARQLV..EKGYAVAICDQVEDA...AEA 32 TLT---........-QR....QNIPMSGIPAAYLDGYVDRLV..SRGFKIAIAEQADNS...EGG 33 TLTTRGq.......VDG....EPVKMAGVPFHAAEQYLARLV..KLGKSVAICEQVGEV...GAG 34 TLTSRDg.......GAA....EKIPMCGVPYHSASAYIEQLI..KKGYKVAICEQTEDP...KAA 35 YC----........HLD....HNFMTASIPTHRLFVHVRRLV..AKGYKVGVVKQTETA...ALK 36 YC----........HLD....HNFMTASIPTHRLFVHVRRLV..AKGYKVGVVKQTETA...ALK 37 ALTKRGk.......NCE....EEIPMCGVPYHALEHYLTKLI..EENYKVAICDQLETP...EEA 38 YC----........HLD....HNFMTASIPTHRLFVHVRRLV..AKGYKVGVVKQTETA...ALK 39 TLTQRGs.......SGG....APIPMAGVPVHAYEGYLARLI..ALGESVAICEQIGDP...GLA 40 YC----........HLD....HNFMTASIPTHRLFVHVRRLV..AKGYKVGVVKQTETA...ALK 41 YC----........HLD....HNFMTASIPTHRLFVHVRRLV..AKGYKVGVVKQTETA...ALK 42 TLTTRGq.......VDG....EPVKMAGVPFHAAEQYLARLV..KLGKSVAICEQVGEV...GAG 43 VLT---........-RR....QDAPMAGIPYHALNTYLKKLV..EAGYKVAICDQMEEP...SKS 44 TLT---........-QR....QNVPMSGIPATCLDGYVDRLV..SRGFKVAIAEQADNT...EGS 45 TLT---........-QR....QGIPMSGIPVSTVDTYVDRLI..GKGFKVAVAEQFGEP...AKE 46 TLTKRGq.......HMG....QEIPMCGVPVHAADDYLQKLI..ASGYRVAVCEQVEDP...AEA 47 TLT---........-QR....QGIPMSGIPVSTVDTYVDRLI..GKGFKVAVAEQFGEP...AKE 48 VLTSRPag......KGR....ERIPMCGVPYHSANNYIAKLV..NKGYKVAICEQVEDP...SKA 49 VLT---........-RR....QDAPMAGIPYHALNTYLKKLV..EAGYKVAICDQMEEP...SKS 50 TLT---........-KR....NGTPMCGVPVHTARTHIARLL..KHGKKVALCEQVSHP...-VP 51 STAFIGallpd...DKK....ETLQFVSMSKGNFELAVRELLl.VRNYRVEVY------...--V 52 SC----........YFE....HNFLNASVPSYRIDYHLERLI..NFGLKVAVVRQTETA...ALK 53 VLTSRPag......KGK....ERIPMCGVPYHSANSYIAKLV..NKGYKVAICEQVEDP...SKA 54 SC----........YFE....HNFLNASVPSYRIDYHLERLI..NFGLKVAVVRQTETA...ALK 55 TQGVIK........YMGpagaKNLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNRAGN...KAS 56 KLT---........-DR....VNMKMVGIPEASFDYWASQFI..AKGYRIARVDQLETA...LGK 57 QY----........-MK....GEQPHCGFPEKNFSVNIEKLV..RKGYRVLVVEQTETP...DQL 58 TTTALRqlg.....SGS....NALSSVSISRNMFETIARDLLleRNDHTVELYEGSGS-...--- 59 TTTALRqlg.....SGS....NALSSVSISRNMFETIARDLLleRNDHTVELYEGSGS-...--- 60 STAFIGallpd...DKK....ETLQFVSMSKGNFELAVRELLl.VRNYRVEVY------...--V 61 TLT---........-KR....ENVPMCGVPYHTSKEYIRKLI..LFDKKVAICEQASN-...STS 62 QY----........-MK....GEQPHCGFPEKNFSVNIEKLV..RKGYRVLVVEQTETP...DQL 63 YA----........HMD....HNFMTASVPTFRLNFHVRRLV..NAGYKIGVVKQTETA...AIK 64 STAFIGallpd...DKK....ETLQFVSMSKGNFELAVRELLl.VRNYRVEVY------...--V 65 TMSALRqlg.....SSS....DGILSASVSKAMFETIARNILleRTDCTLELYEGSGS-...--- 66 KI--AG........GGR....ANMQLAGIPEMSFEYWAAQFI..QMGYKVAKVDQRESM...LAK 67 KLVPGKlti10pqdCNH....RQFAYCSFPDVRLNVHLERLV..HHNLKVAVVEQAETS...AIK 68 KI--AG........GGR....ANMQLAGIPEMSFEYWAAQFI..QMGYKVAKVDQRESM...LAK 69 TTSVIRqlgr....SDH....TGLPSVTMTVTVFRQFLREALf.KLGKRIEIW------...ASP 70 SLTNRA........YSH....GKVPFAGFPVHQLSRHLKMLVn.NCGYSVTIAEQFKKK...DVA 71 RVSKKK........TSK....SDVSMAGFPFFKLDRYLKILVe.DLKKCVALSEEVIRPvddLSS 72 KLVPGKlti10pqdCNH....RQFAYCSFPDVRLNVHLERLV..HHNLKVAVVEQAETS...AIK 73 SLTNRA........YSH....GKVPFAGFPVHQLSRHLKMLVn.NCGYSVTIAEQFKKK...DVA 74 TTSVLKh.......HNV....SNTSYCNLSPSLFIKFAEDVLs.NLAKRVEIW------...GAN 75 AF----........-MR....GSYAHAGFPEHAASKFADQLM..NHGYKVARIEQTETP...QML 76 TQSVLKncq10takNFH....EPTKYVTVSLQVLATLLKLCLl.DLGYKVEIYDK----...--- 77 TQSVLKncq10takNFH....EPTKYVTVSLQVLATLLKLCLl.DLGYKVEIYDK----...--- 78 KMTV--........SGV....GKCRQVGISESGIDDAVDKLI..ARGYKVGRIEQMESA...NQA 79 KMTV--........SGV....GKCRQVGISESGIDDAVDKLI..ARGYKVGRIEQMESA...NQA 80 YA----........HMD....HNFMTA---------------..--GYKIGVVKQTETA...AIK 81 YA----........HMD....HNFMTA---------------..--RYKIGVVKQTETA...AIK 82 KMTM--........SGV....GKCRQVGISESGIDEAVQKLL..ARGYKVGRIEQLETS...DQA 83 ------........---....---------------------..---------------...--- 84 ------........---....---------------------..---------------...--- 85 ------........---....---------------------..---------------...--- 86 SDVCVKtftlst..DNS....QQMKYISVNRGQYEKVVRETIv.LLRCSVELYSSEQG-...--- 87 YC----........HLD....HNFMTASIPTHRLFVHVRRLV..AKGYKVGVVKQTETA...ALK 88 ------........---....---------------------..---------------...--- 89 ------........---....---IMNDISEDLEFRFLKRLId.DVKPTLIIANRSQDL...EFI 90 ------........---....---IMNDISEDLEFRFLKRLId.DVKPTLIIANRSQDL...EFI 91 ------........---....--GPRSGIPSASFP-------..---------------...--- 92 ------........---....--GPRSGIPSASFP-------..---------------...--- 93 ------........---....---------------------..---------------...--- 94 ------........---....---------------------..---------------...--- 95 ------........---....---IMNDISEDLEFRFLKRLId.DVKPTLIIANRSQDL...EFI 96 ------........---....---------------------..---------------...--- 97 ------........---....---------------------..---------------...--- 98 ------........---....---------------------..---------------...--- 99 ------........---....---------------------..---------------...--- 100 ------........---....---------------------..---------------...--- 101 ------........---....---------------------..---------------...--- 102 TPPIEQvas11iisLGK....RSLLQMGFPVYSLTTHLSTLL..DKGWTVIVIDELVTN...--K 103 ------........---....---------------------..---------------...--- 104 ------........---....---------------------..---------------...--- 105 TPPIEQvas11iisLGK....RSLLQMGFPVYSLTTHLSTLL..DKGWTVIVIDELVTN...--K 106 VF----........-MK....GNWAHSGFPEIAFGRYSDSLV..QKGYKVARVEQTETP...EMM 107 TY----........-MR....GEFAHSGFPEISFDKMSTILV..DRGFKVARVEQTETP...DMM 108 ------........---....---------------------..---------------...--- 109 ------........---....---------------------..---------------...--- 110 ------........---....---------------------..---------------...--- 111 ------........---....---------------------..---------------...--- 112 ------........---....---------------------..---------------...--- 113 TQGVIK........YMGpagaKNLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNRAGN...KAS 114 ------........---....---------------------..---------------...--- 115 ------........---....---------------------..---------------...--- 116 ------........---....---------------------..---------------...--- 117 ------........---....---------------------..---------------...--- 118 ------........---....---------------------..---------------...--- 119 ------........---....---------------------..---------------...--- 120 TLTKRDa.......KKE....NPIPMCGVPYHSADSYIDTLV..NNGYKVAICEQMEDP...KQT 121 ------........---....---------------------..---------------...--- 122 TQGVIK........YMGpagaKNLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNRAGN...KAS 123 ------........---....---------------------..---------------...--- 124 ------........---....---------------------..---------------...--- 125 ------........---....---------------------..---------------...--- 126 TQGVIK........YMGpagaKNLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNRAGN...KAS 127 TTSVLKh.......HNV....SNTSYCNLSPSLFIKFAEDVLs.NLAKRVEIW------...GAN 128 ------........---....---------------------..---------------...--- 129 ------........---....---------------------..---------------...--- 130 ------........---....---------------------..---------------...--- 131 TQGVIK........YMGpagaKNLQSVVLSKMNFESFVKDLLl.VRQYRVEVYKNRAGN...KAS 132 ------........---....---------------------..---------------...--- 133 ------........---....---------------------..---------------...--- 134 ------........---....---------------------..---------------...--- 135 ------........---....---------------------..---------------...--- 136 ------........---....---------------------..---------------...--- 137 ------........---....---------------------..---------------...--- 138 ------........---....---------------------..---------------...--- 139 ------........---....---------------------..---------------...--- 140 ------........---....---------------------..---------------...--- 141 ------........---....---------------------..---------------...--- 142 ------........---....---------------------..---------------...--- 143 ------........---....---------------------..---------------...--- 144 ------........---....---------------------..---------------...--- 145 ------........---....---------------------..---------------...--- 146 ------........---....---------------------..---------------...--- 147 ------........---....---------------------..---------------...--- 148 YC----........HLD....HNFMTASIPTHRLFVHVRRLV..AKGYKVGVVKQTETA...ALK 149 ------........---....---------------------..---------------...--- 150 ------........---....---------------------..---------------...--- 151 YA----........HMD....HSFMTASVPTFRLNVHVRGLV..NAGYKVGVVKQTETA...AIK 110 120 130 1 | | | 1 E........GLVRREVTQLLTPGTL........LQ...ESLL....PREANYLAAIAT....... 2 E........GLVRREVTQLLTPGTL........LQ...ESLL....PREANYLAAIAT....... 3 E........GLVRREVTQLLTPGTL........TQ...EALL....PREANYLAAIAT....... 4 E........GLVRREVTQLLTPGTL........TQ...EALL....PREANYLAAIAT....... 5 E........GLVRREVTQLLTPGTL........TQ...EALL....PREANYLAAIAT....... 6 E........GLVRREVTQLLTPGTL........TQ...EALL....PREANYLAAIAT....... 7 K........GPVERKVVRIVTPGTI........SD...EALLq...ERQDNLLAAIWQd...... 8 K........GPVERKVVRIVTPGTI........SD...EALLq...ERQDNLLAAIWQd...... 9 K........GPVERQVVRIITPGTV........SD...EALL....DERRDNLLAAVVgd..... 10 K........GPVERKVVRIVTPGTI........SD...EALLq...ERQDNLLAAIWQd...... 11 K........GPVERQIVRIVTPGTV........SD...EALLp...ERQDNLIAAVYQe...... 12 K........GPVERQVVRIITPGTV........SD...EALL....DERRDNLLAAILgd..... 13 K........GPVERQVVRIITPGTV........SD...EALL....DERRDNLLAAILgd..... 14 Ken......---EWYLAFKASPGNL........SQf..EDIL....FGNNDMSASVGVmgi10vd 15 K........GPVERKVVRIVTPGTI........SD...EALLq...ERQDNLLAAIWQd...... 16 Ken......---EWYLAFKASPGNL........SQf..EDIL....FGNNDMSASVGVmgi10vd 17 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMSASIGVvgv10vd 18 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMSASIGVvgv10vd 19 Earc13kfdRVVRREICRIITKGTQtysv....LD...GDPS....ENYSRYLLSLKEkeeetsg 20 K........GPVERKVVRIVTPGTI........SD...EALLq...ERQDNLLAAIWQd...... 21 Earc13kfdRVVRREICRIITKGTQtysv....LD...GDPS....ENYSRYLLSLKEkeeetsg 22 Earc13kydRVVRREICRIITKGTQtysv....LE...GDPS....ENYSKYLLSLKEkeedssg 23 Earc13kydRVVRREICRIITKGTQtysv....LE...GDPS....ENYSKYLLSLKEkeedssg 24 Earc13kydRVVRREICRIITKGTQtysv....LE...GDPS....ENYSKYLLSLKEkeedssg 25 Earc13kydRVVRREICRIITKGTQtysv....LE...GDPS....ENYSKYLLSLKEkeedssg 26 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMATSIGImgi10vd 27 Ken......---DWQLAFKASPGNL........TQf..EEIL....FGNNDMSTAVGVvgi10se 28 V........GVVKREVVQVITPGTV........VD...SSKP....DSQNNFLVSIDRe...... 29 Qaek.....RMVERQVTKLLTPGTL........TD...DSMLp...AKRNNFLAAIAMv...... 30 K........GVVKREVVQLITPGTV........MD...GKGIh...ESENNFIASVSAc...... 31 Qaek.....RMVERQVTKLLTPGTL........TD...DSMLp...AKRNNFLAAIAMv...... 32 K........GLVPRTINRLITPGAL........LS...SSLLp...EKANNYIIAISQv...... 33 K........GPVERKVVRIVTPGTL........TD...SALLe...DKETNRIVAVSPd...... 34 K........GVVKREVVQLITPGTV........MD...GKGIh...ESENNFIASVSAc...... 35 Aigdnks..SVFSRKLTALYTKSTLige16svnID...EVMT....DTSTNYLLCIYEeke11kk 36 Aigdnrs..SLFSRKLTALYTKSTLige16avnVD...EIMT....DTSTSYLLCISEnke11kk 37 Kkrdgyk..AVVTRDVTRIITPGTI........IE...ENLIs...VTEPNYLTSLVIpkn.... 38 Aigdnks..SVFSRKLTALYTKSTLige16svnID...EVMT....DTSTNYLLCIYEeke11kk 39 K........GLVERKVVRIVTPGTI........TD...EVLLe...ERRDTLLMALSRs...... 40 Aigdnks..SVFSRKLTALYTKSTLige16svnID...EVMT....DTSTNYLLCIYEeke11kk 41 Aigdnrs..SLFSRKLTALYTKSTLige16avnVD...EIMT....DTSTSYLLCISEnke11kk 42 K........GPVERKVVRIVTPGTL........TD...SALLe...DKETNRIVAVSPd...... 43 K........KLIRREVTRVVTPGSI........VE...DEFL....SETNNYMAVVSEe...... 44 K........GLVPRTINRLITPGAL........LS...SSLLp...EKANNYVLAINQv...... 45 Keskki...GPMARDIQRFVTPGTL........LS...STLLq...EKFNNYIVAINRi...... 46 Kkrgsk...SVVRRDVVRLVTPGTI........TE...DKLLs...PSESNYLMALARirsgs.. 47 Keskki...GPMARDIQRFVTPGTL........LS...STLLq...EKFNNYIVAINRi...... 48 K........GIVKRDVIRVITPGTF........FE...RE--....---TGGLCSLYRk...... 49 K........KLIRREVTRVVTPGSI........VE...DEFL....SETNNYMAVVSEe...... 50 G........ELTQRKVIEIISPGTA........VE...DDFLs...QGFSQYLATVCAs...... 51 K........NSSDWEIEYRGSPGNL........LQf..EDIL....FSNKEVLVGNSIisl11gg 52 Stsssrn..TLFDRRVARVLTKGTT........LD...DSFF....RFEQTQHGTLQAsqf19ks 53 K........GIVKREVVRVITPGTF........FE...RDTG....----GLASLYK-k...... 54 Stsssrn..TLFDRRVARVLTKGTT........LD...DSFF....RFEQTQHGTLQAsqf19ks 55 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMSASIGVvgv10vd 56 Eikd11keeKVVQRGLTQVLTSGTL........VD...EAMLt...SDLSTYCMAIKEslqsdne 57 Eqrr10skdKVVKREVCAVVTKGTL........TD...GEMLlt..NPDASYLMALTEgge10pt 58 -........---NWRLVKTGSPGNI........GSf..EDVL....FANNEMQDTPVVvsi10hd 59 -........---NWRLVKTGSPGNI........GSf..EDVL....FANNEMQDTPVVvsi10hd 60 K........NSSDWEIEYRGSPGNL........LQf..EDIL....FSNKEVLVGNSIisl11gg 61 G........GPLEREVVEVITPGVI........ID...EDFLn...DDINNYLVAISDy...... 62 Eqrr10skdKVVKREVCAVVTKGTL........TD...GEMLlt..NPDASYLMALTEgge10pt 63 Shganrt..GPFFRGLSALYTKATLeaa10ggcGG...EEGF....GSQSNFLVCVVDerv16ms 64 K........NSSDWEIEYRGSPGNL........LQf..EDIL....FSNKEVLVGNSIisl11gg 65 -........---NWRLTKSGTPGNI........GSf..EDIL....FANNDMEDSPVIval10re 66 Emregsk..GIVKRELQCILTSGTL........TD...GDMLh...SDLATFCLAIREepg21kl 67 KhdpgasksSVFERKISNVFTKATFgvnstfv.LR...GKRI....LGDTNSIWALSRdvhqgk. 68 Emregsk..GIVKRELQCILTSGTL........TD...GDMLh...SDLATFCLAIREepg21kl 69 S........GRMNWKVVKQASPGNL........QDv..EDELggq.FEGAPVILAV--kisakas 70 Dnea.....NKFYRRVTRIVTPGTF........ID...EAFEn...LRENTYLLNIEFpen11ad 71 K........NMYIRSVTRVITPGTL........ID...ENFMn...PYESNYILTVVFdpn22cf 72 KhdpgasksSVFERKISNVFTKATFgvnstfv.LR...GKRI....LGDTNSIWALSRdvhqgk. 73 Dnea.....NKFYRRVTRIVTPGTF........ID...EAFEn...LRENTYLLNIEFpen11ad 74 S........AKTGFELLKQASPGNMqm......LE...DLLV....SENYQESTAISDssv17kq 75 Eern10tkeKVVRREVCRVTSNGTRtyg11dlgSA...SSTL....DPTAKHLLAIKEfhnpetg 76 -........---GWKLIKSASPGNI........EQ...VNEL....MNMNIDSSIIIAslk11qd 77 -........---GWKLIKSASPGNI........EQ...VNEL....MNMNIDSSIIIAslk11qd 78 Kargvh...SVIERKLVHVSTPSTA........VD...NIGT....DAVHLLALKEVTlassg.. 79 Kargvh...SVIERKLVHVSTPSTA........VD...NIGT....DAVHLLALKEVTlassg.. 80 Shganrt..GPFFRGLSALYTKATLeaa10ggcGG...EEGF....GSQSNFLVCVVDerv16ms 81 Shganrt..GPFFRGLSALYTKATLeaa10ggcGG...EEGF....GSQSNFLVCVVDerv16ms 82 Kargan...TIIPRKLVQVLTPSTA........SE...GNIG....PDAVHLLAIKEIkmelqkc 83 -........----------------........--...----....ELAEIHLCVLWN....... 84 -........----------------........--...----....ELAEIHLCVLWN....... 85 -........----------------........--...----....ELAEIHLCVLWN....... 86 -........---EWKMTKRGSPGNT........VDfeqEIGV....SDQAPILAIYIHpgdd... 87 Aigdnks..SVFSRKLTALYTKSTLige16svnID...EVMT....DTSTNYLLCIYEeke11kk 88 -........------VTRVITPGTL........ID...ENFMn...PYESNYILTVVFdpn22cf 89 Kfl......TTRYDPQEKIYEDGTT........EE...GTSE....DTVPTWDSSLAY....... 90 Kfl......TTRYDPQEKIYEDGTT........EE...GTSE....DTVPTWDSSLAY....... 91 -........----SPQPPMAGPGGI........EE...EDEE....EPAEIHLCVLWS....... 92 -........----SPQPPMAGPGGI........EE...EDEE....EPAEIHLCVLWS....... 93 -........----------------........--...-AIS....AHSPSVIVAVVEgrgla.. 94 -........----------------........--...-AIS....AHSPSVIVAVVEgrgla.. 95 Kfl......TTRYDPQEKIYEDGTT........EE...GTSE....DTVPTWDSSLAY....... 96 -........----------------........--...----....------------....... 97 -........----------------........--...----....------------....... 98 -........----------------........--...-LLG....PSIDCVLCCIYEvprdi.. 99 -........----------------........--...-LLG....PSIDCVLCCIYEvprdi.. 100 -........----------------........--...NTTT....KNVNSDVVIVVMegrgsc. 101 -........----------------........--...----....-------MS---vyspkad 102 S........GPKQRAVSQVYSPSCN........LE...DCPEl...----PYVLSIYFsq..... 103 -........-------------SSHdl......ID...DADMss..NDISLLLGLLIM....... 104 -........-------------SSHdl......ID...DADMss..NDISLLLGLLIM....... 105 S........GPKQRAVSQVYSPSCN........LE...DCPEl...----PYVLSIYFsq..... 106 Earc13kydRVVRREICRIITKGTQtysv....LE...GDPS....ENYSKYLLSLKEkeedssg 107 Terc12kfdKVVAREICQITNRGTQ........VF...GSQCkigpNHQPNYMLAIVEkdegt.. 108 -........----------------........--...----....------------....... 109 -........----------------........--...----....------------....... 110 -........----------------........--...----....------------....... 111 -........----------------........--...----....------------....... 112 -........----------------........--...----....------------....... 113 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMSASIGVvgv10vd 114 -........----------------........--...----....------------....... 115 -........----------------........--...----....------------....... 116 -........----------------........--...----....------------....... 117 -........----------------........--...----....------------....... 118 -........----------------........--...----....------------....... 119 -........----------------........--...----....------------....... 120 K........GMVRREVVRIVTPGTV........ME...QGGVd...DKQNNYILSFVMn...... 121 -........----------------........--...----....------------....... 122 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMSASIGVvgv10vd 123 -........----------------........--...----....------------....... 124 -........----------------........--...----....------------....... 125 -........----------------........--...----....------------....... 126 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMSASIGVvgv10vd 127 S........AKTGFELLKQASPGNMqm......LE...DLLV....SENYQESTAISDssv17kq 128 -........----------------........--...----....------------....... 129 -........----------------........--...----....------------....... 130 -........----------------........--...----....------------....... 131 Ken......---DWYLAYKASPGNL........SQf..EDIL....FGNNDMSASIGVvgv10vd 132 -........----------------........--...----....------------....... 133 -........----------------........--...----....------------....... 134 -........----------------........--...----....------------....... 135 -........----------------........--...----....------------....... 136 -........----------------........--...----....------------....... 137 -........----------------........--...----....------------....... 138 -........----------------........--...----....------------....... 139 -........----------------........--...----....------------....... 140 -........----------------........--...----....------------....... 141 -........----------------........--...----....------------....... 142 -........----------------........--...----....------------....... 143 -........----------------........--...----....------------....... 144 -........----------------........--...----....------------....... 145 -........----------------........--...----....------------....... 146 -........----------------........--...----....------------....... 147 -........----------------........--...----....------------....... 148 Aigdnks..SVFSRKLTALYTKSTLige16svnID...EVMT....DTSTNYLLCIYEeke11kk 149 -........----------------........--...----....------------....... 150 -........----------------........--...----....------------....... 151 Shganra..GPFFRGLSGLYTKATLeaa10ggcVG...EEGF....GGQSNFLVCVVDerv17as 40 150 160 170 180 | | | | | 1 .GDGWGLAFLDVSTGEFKGTVLKS....KSALYDE.LFRHRPAE.VLLAP.....ELLE.....N 2 .GDGWGLAFLDVSTGEFKGTVLKS....KSALYDE.LFRHRPAE.VLLAP.....ELLE.....N 3 .GDGWGLAFLDVSTGEFKGTLLKS....KSALYDE.LFRHRPAE.VLLAP.....ELRE.....N 4 .GDGWGLAFLDVSTGEFKGTLLKS....KSALYDE.LFRHRPAE.VLLAP.....ELRE.....N 5 .GDGWGLAFLDVSTGEFKGTLLKS....KSALYDE.LFRHRPAE.VLLAP.....ELRE.....N 6 .GDGWGLAFLDVSTGEFKATLLKS....KSALYDE.LFRHRPAE.VLLAP.....ELRE.....N 7 .SKGFGYATLDISSGRFRLSEPAD....RETMAAE.LQRTNPAE.LLYAE.....DFAE.....M 8 .SKGFAYATLDISSGRFRLSEPAD....RETMAAE.LQRTNPAE.LLYAE.....DFAE.....M 9 .ERLFGLAILDITSGRFNVQEIQG....WENLLAE.LERLNPAE.LLYPD.....DWPA.....G 10 .SKGFGYATLDISSGRFRLSEPAD....RETMAAE.LQRTNPAE.LLYAE.....DFAE.....M 11 .KEKFGLATLDMTSGRFQLCEPAD....KETLRAE.LQRIAPVE.LLYCE.....EFNE.....M 12 .ERLFGLAVLDITSGRFSVQEIKG....WETLLAE.LERLNPAE.LLIPD.....DWPQ.....G 13 .ERLFGLAVLDITSGRFSVQEIKG....WETLLAE.LERLNPAE.LLIPD.....DWPQ.....G 14 gQRHVGVGYVDSTQRKLGLCEFPEndq.FSNLEAL.LIQIGPKE.CVLPG.....GETTg....D 15 .GKGYGYATLDISSGRFRLSEPAD....RETMAAE.LQRTNPAE.LLYAE.....DFAE.....M 16 gQRHVGVGYVDSTQRKLGLCEFPEndq.FSNLEAL.LIQIGPKE.CVLPG.....GETTg....D 17 gQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CVLPG.....GETAg....D 18 gQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CVLPG.....GETAg....D 19 hTRVYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTL.VAHYPPVQ.ILFEK.....GNLS.....T 20 .GKGYGYATLDISSGRFRLSEPAD....RETMAAE.LQRTNPAE.LLYAE.....DFAE.....M 21 hTRVYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTL.VAHYPPVQ.ILFEK.....GNLS.....T 22 hTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTL.VAHYPPVQ.VLFEK.....GNLS.....K 23 hTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTL.VAHYPPVQ.VLFEK.....GNLS.....K 24 hTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTL.VAHYPPVQ.VLFEK.....GNLS.....K 25 hTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTL.VAHYPPVQ.VLFEK.....GNLS.....K 26 gQRQVGVGDVDSTQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CILPG.....GETAg....D 27 gQRLVGVGYVDSTLRKLGVCEFPDndq.FSNLEAL.LVQIGPKE.CVMPG.....GETAg....D 28 .GNQFGLAYMDLVTGDFYVTGLLD....FTLVCGE.IRNLKARE.VVLGY.....DLSE.....E 29 .EDKWGLAHADISTGEFFTCQSSN....LDDLAVE.LLRLQPSE.VLIPT.....SAPD.....I 30 .SNGYGLALSDLTTGENLAVLIER....LEDVISE.IYSVGARE.IVVSG.....SLDA.....D 31 .EDKWGLAHADISTGEFFTCQSSN....LDDLAVE.LLRLQPSE.VLIPT.....SAPD.....I 32 .GSLYGLSCLDLSTGTFLVAEYDN....TKDLIEA.VYRLAPTE.LLSHA.....KFYQk....N 33 .KKYIGLAWASLQSGEFKTKLTT-....VDKLDDE.LARLQAAE.ILLPD.....SKNA.....P 34 .SNGYGLALSDLTTGENLAVLIER....LEDVISE.IYSVGARE.IVVSG.....SLDA.....D 35 gNLSVGVVGVQPATGEVVFDCFQDsas.RLELETR.ISSLQPVE.LLLPS.....DLSE.....P 36 gNIFIGIVGVQPATGEVVFDSFQDsas.RSELETR.MSSLQPVE.LLLPS.....ALSE.....Q 37 .KKTASICCVDLSTSKIFVINVP-....ETEILNE.LARLKSRE.ILLSE.....NLKSs....N 38 gNLSVGVVGVQPATGEVVFDCFQDsas.RLELETR.ISSLQPVE.LLLPS.....DLSE.....P 39 .KNCYGLAWADLAGGRFLVNEVNS....EEALEAE.LARLEPAE.LLLPD.....EDAW.....P 40 gNLSVGVVGVQPATGEVVFDCFQDsas.RLELETR.ISSLQPVE.LLLPS.....DLSE.....P 41 gNIFIGIVGVQPATGEVVFDSFQDsas.RSELETR.MSSLQPVE.LLLPS.....ALSE.....Q 42 .KKYIGLAWASLQSGEFKTKLTT-....VDKLDDE.LARLQAAE.ILLPD.....SKNA.....P 43 .KGRYCTVFCDVSTGEVLVHESSD....EQETLDL.LKNYSISQ.IICPE.....HLKS.....S 44 .GSLYGLSCLDLSIGTFLVAEYDN....TKDLIEA.ICRLAPTE.LLSHA.....KFYQk....N 45 .GSLFGFACLDLSTGSFFIEECEN....TKELVDE.ICRLAPSE.VLSCN.....KFYNk....E 46 .EPAYALAWIDISTGIFRLAETA-....ESRLLAD.ILRIEPRE.LILPD.....TVFH.....D 47 .GSLFGFACLDLSTGSFFIEECEN....TKELVDE.ICRLAPSE.VLSCN.....KFYNk....E 48 .GKSYLVSYLNLSVGEFIGAKVK-....EEELIDF.LSKFNIRE.VLVKK.....GEKL.....P 49 .KGRYCTVFCDVSTGEVLVHESSD....EQETLDL.LKNYSISQ.IICPE.....HLKS.....S 50 .DATVAFSYLEVSTGAFFITSFPRaea.ADALQKE.FGRVQPSE.VLLSA.....SVLR.....S 51 gQRRVGVASVEQNDCKFQLLEFLDddf.FTELEAT.VVLLGPKE.CLLPS.....IEGE.....Y 52 gRVQVGLIAIQLSSGTTVYDHFQDdfl.RSELQTR.LSHFQPCE.LIYSN.....KLSS.....E 53 .GNHYYVGYLNLAVGEFLGAKVK-....IEELLDL.LSKLNIKE.ILVKK.....GEKL.....P 54 gRVQVGLIAIQLSSGTTVYDHFQDdfl.RSELQTR.LSHFQPCE.LIYSN.....KLSS.....E 55 gQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CVLPG.....GETAg....D 56 .EPSFGICFIDTSTGGFHMCEFTDdih.RTKLDTL.LTQVRPKE.LILEK.....SKIS.....Q 57 aEHNFGVCLVDVATQKIILGQFKDdqd.CSALSCL.LSEMRPVE.IIKPA.....KVLS.....Y 58 gRCVIGMAYVDLTRRVLGLAEFLDdsr.FTNLESS.LIALGAKE.CIFPA.....ESGKsn...E 59 gRCVIGMAYVDLTRRVLGLAEFLDdsr.FTNLESS.LIALGAKE.CIFPA.....ESGKsn...E 60 gQRRVGVASVEQNDCKFQLLEFLDddf.FTELEAT.VVLLGPKE.CLLPS.....IEGE.....Y 61 .KDYYSFSYIDLSTSSLGIMFYENgf..FEKLKRD.LEKYSPKE.IIVSE.....NFYY.....E 62 aEHNFGVCLVDVATQKIILGQFKDdqd.CSALSCL.LSEMRPVE.IIKPA.....KVLS.....Y 63 fDVRVGVVGVEISTGEVVYEEFNDnfm.RSGLEAV.ILSLSPAE.LLLGQ.....PLSQ.....Q 64 gQRRVGVASVEQNDCKFQLLEFLDddf.FTELEAT.VVLLGPKE.CLLPS.....IEGE.....Y 65 sQLYVGLSFLDMTNRKLGLAEFPEdsr.FTNVESA.LVALGCKE.CLLPA.....DCEKsi...D 66 nTKIFGAAFIDTATGELQMLEFEDdse.CTKLDTL.MSQVRPME.VVMER.....NNLS.....T 67 .VAKYSLISVNLNNGEVVYDEFEEpnlaDEKLQIR.IKYLQPIE.VLVNT.....DDLP.....L 68 nTKIFGAAFIDTATGELQMLEFEDdse.CTKLDTL.MSQVRPME.VVMER.....NNLS.....T 69 eARTVGVCFADASVRELGVSEFLDndl.YSNFEAL.LIQLGVKE.CIVTQ.....DKGEkekdpE 70 tSLKVGICWCDVSTGEIFVQQVY-....LRDLVSA.ITRIQPKE.ILLDE.....RLLE.....F 71 aDCKIGLSWLDLSTGEFFTQDSN-....LQRLAGD.LTRISPRE.IVLDE.....SLKS.....F 72 .VAKYSLISVNLNNGEVVYDEFEEpnlaDEKLQIR.IKYLQPIE.VLVNT.....DDLP.....L 73 tSLKVGICWCDVSTGEIFVQQVY-....LRDLVSA.ITRIQPKE.ILLDE.....RLLE.....F 74 dQRIIGVAFIDPILKKLGVSEFVDsda.YTNFEAL.IVQVGAKE.CIISQ.....SGHE.....S 75 .KSSYGVCMIDTTTAHIRIGQFEDddy.RSQLRTL.LANVIVVQ.AIVER.....GSIS.....S 76 gNCIIGVAFIDTTAYKVGMLDIVDnev.YSNLESF.LIQLGVKE.CLVQDltsnsNSNA.....E 77 gNCIIGVAFIDTTAYKVGMLDIVDnev.YSNLESF.LIQLGVKE.CLVQDltsnsNSNA.....E 78 .FQVFGFAFLDYAALKIWVGSVQDdds.SAALGAL.LMQVSPRE.LIYET.....SGIS.....K 79 .FQVFGFAFLDYAALKIWVGSVQDdds.SAALGAL.LMQVSPRE.LIYET.....SGIS.....K 80 fDVRVGVVGVEISTGEVVYEEFNDnfm.RSGLEAV.ILSLSPAE.LLLGQ.....PLSQ.....Q 81 fDVRVGVVGVEISTGEVVYEEFNDnfm.RSGLEAV.ILSLSPAE.LLLGQ.....PLSQ.....Q 82 .STVYGFAFVDCAALRFWVGSISDdas.CAALGAL.LMQVSPKE.VLYDS.....KGLS.....R 83 .SGYLGIAYYDTSDSTIHFMPDAPdhesLKLLQRV.LDEINPQS.VVTSA.....KQDE.....N 84 .SGYLGIAYYDTSDSTIHFMPDAPdhesLKLLQRV.LDEINPQS.VVTSA.....KQDE.....N 85 .SGYLGIAYYDTSDSTIHFMPDAPdhesLKLLQRV.LDEINPQS.VVTSA.....KQDE.....N 86 .DNRVTLCAWDAGNVRIVISEYIDtps.FSQTEQC.IFGLCPTEyILVNE.....GSVA.....P 87 gNLSVGVVGVQPATGEVVFDCFQDsas.RLELETR.ISSLQPVE.LLLPS.....DLSE.....P 88 aDCKIGLSWLDLSTGEFFTQDSN-....LQRLAGD.LTRISPRE.IVLDE.....SLKS.....F 89 .ST------------DETTAEKEE....KEEDEDD.DDEGLPAK.LNKLP.....NNFF.....R 90 .ST------------DETTAEKEE....KEEDEDD.DDEGLPAK.LNKLP.....NNFF.....R 91 .SGYLGIAYYDTSDSTIHFMPDAPdhesLKLLQRV.LDEINPQS.VVTSA.....KQDE.....A 92 .SGYLGIAYYDTSDSTIHFMPDAPdhesLKLLQRV.LDEINPQS.VVTSA.....KQDE.....A 93 .RGEIGMASIDLKNPQIILSQFADntt.YAKVITK.LKILSPLE.IIMSN.....TACA.....V 94 .RGEIGMASIDLKNPQIILSQFADntt.YAKVITK.LKILSPLE.IIMSN.....TACA.....V 95 .ST------------DETTAEKEE....KEEDEDD.DDEGLPAK.LNKLP.....NNFF.....R 96 .-----------------------....-------.--------.-----.....----.....- 97 .-----------------------....-------.--------.-----.....----.....- 98 .STRIGLCIINCNTGQMYLSDFMDsqi.YIRVVHK.LQIYQPTE.ILIPS.....SSLA.....P 99 .STRIGLCIINCNTGQMYLSDFMDsqi.YIRVVHK.LQIYQPTE.ILIPS.....SSLA.....P 100 .EGHIGIALHDTCFPEIHLCEFVDsre.YTTLKTM.INVHEAFD.IVIQN.....GNEE.....R 101 .SMDVGVSVLKLKTLELTLMSFCDsst.FVRTVNQ.IQVYEPTS.IILPE.....AQSH.....S 102 .DQLLGITLFSAMNGHSIIFPVSWtd..RDKVTRL.LISYHIRE.IVIWA.....DSGV.....C 103 .EANPTVCLVPAFLEDWIFDYIKT....KCDEINC.RLELQPIK.FFKKW.....DLLQ.....S 104 .EANPTVCLVPARLEDWIFDYIKT....KCDEINC.RLELQPIK.RFKKW.....DLLQ.....S 105 .DDLLGITLFSAMNGHSIIFPVSWtd..RDKVTRL.LISYHIRE.IVIWA.....DSGV.....C 106 hTRAYGVCFVDTSLGKFFIGQFSDdrh.CSRFRTL.VAHYPPVQ.VLFEK.....GNLS.....K 107 .CSRYGVCFIDTSIGDFHLGEFEDdkn.CSRLLTL.VSHHMPVL.FLNEK.....SALS.....Q 108 .-----------------------....-------.--------.-----.....----.....- 109 .-----------------------....-------.--------.-----.....----.....- 110 .-----------------------....-------.--------.-----.....----.....- 111 .-----------------------....-------.--------.-----.....----.....- 112 .-----------------------....-------.--------.-----.....----.....- 113 gQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CVLPG.....GETAg....D 114 .-----------------------....-------.--------.-----.....----.....- 115 .-----------------------....-------.--------.-----.....----.....- 116 .-----------------------....-------.--------.-----.....----.....- 117 .-----------------------....-------.--------.-----.....----.....- 118 .-----------------------....-------.--------.-----.....----.....- 119 .-----------------------....-------.--------.-----.....----.....- 120 .QPEIALSYCDVSTGELKVTHFND....EATLLNE.ITTINPNE.VVIND.....NISD.....N 121 .-----------------------....-------.--------.-----.....----.....- 122 gQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CVLPG.....GETAg....D 123 .-----------------------....-------.--------.-----.....----.....- 124 .-----------------------....-------.--------.-----.....----.....- 125 .-----------------------....-------.--------.-----.....----.....- 126 gQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CVLPG.....GETAg....D 127 dQRIIGVAFIDPILKKLGVSEFVDsda.YTNFEAL.IVQVGAKE.CIISQ.....SGHE.....S 128 .-----------------------....-------.--------.-----.....----.....- 129 .-----------------------....-------.--------.-----.....----.....- 130 .-----------------------....-------.--------.-----.....----.....- 131 gQRQVGVGYVDSIQRKLGLCEFPDndq.FSNLEAL.LIQIGPKE.CVLPG.....GETAg....D 132 .-----------------------....-------.--------.-----.....----.....- 133 .-----------------------....-------.--------.-----.....----.....- 134 .-----------------------v...KEELEDF.LLKVKPI-.-----.....----.....- 135 .-----------------------....-------.--------.-----.....----.....- 136 .-----------------------....-------.--------.-----.....----.....- 137 .-----------------------....-------.--------.-----.....----.....- 138 .-----------------------....-------.--------.-----.....----.....- 139 .-----------------------....YDLLIDMgLNRYHPVI.LNPDP.....GELD.....E 140 .-----------------------....-------.--------.-----.....----.....- 141 .-----------------------....-------.--------.-----.....----.....- 142 .-----------------------....-------.--------.-----.....----.....- 143 .-----------------------....-------.--------.-----.....----.....- 144 .-----------------------....-------.--------.-----.....----.....- 145 .-----------------------....-------.--------.-----.....----.....- 146 .-----------------------....-------.--------.-----.....----.....- 147 .-----------------------....-------.--------.-----.....----.....- 148 gNLSVGVVGVQPATGEVVFDCFQDsas.RLELETR.ISSLQPVE.LLLPS.....DLSE.....P 149 .-----------------------....-------.--------.-----.....----.....- 150 .-----------------------....-------.--------.-----.....----.....- 151 fDVRVGVVGVEISTGEVVHGEFNDnfm.RSGLEAV.I-------.-----.....----.....- 190 200 210 220 230 | | | | | 1 GAFLDE...FRKRFPVMLSEAPFEPE........GEGPLALRRARGALLAYAQRTQG.G...... 2 GAFLDE...FRKRFPVMLSEAPFEPE........GEGPLALRRARGALLAYAQRTQG.G...... 3 EAFVAE...FRKRFPVMLSEAPFEPQ........GEGPLALRRAQGALLAYARATQG.G...... 4 EAFVAE...FRKRFPVMLSEAPFEPQ........GEGPLALRRAQGALLAYARATQG.G...... 5 EAFVAE...FRKRFPVMLSEAPFEPQ........GEGPLALRRAQGALLAYARATQG.G...... 6 EAFVAQ...FRKRFPVMLSEAPFDPE........GEAPLALSRARGALLAYARATQG.G...... 7 SLIEGR...RGLRRRPLWEFEIDTARqql16gfgVENAPRGLCAAGCLLQYAKDTQR.T...... 8 SLIEGR...RGLRRRPLWEFEIDTARqql16gfgVENAPRGLCAAGCLLQYAKDTQR.T...... 9 LPLEKR...RGAHRRAPWDFDFDSAYksl16gfgCDGLGLAIGAAGCLLAYARETQR.T...... 10 SLIEGR...RGLRRRPLWEFEIDTARqql16gfgVENAPRGLCAAGCLLQYAKDTQR.T...... 11 AAIEHC...KGLRRRPIWEFELSTAItll16afgVEKSPLGLSAAGCLLQYAKETQR.T...... 12 LPAEKR...RGVRRRAPWDFDRDSAHksl16gfgCQNLTLAIGAAGCLLAYAKETQR.T...... 13 LPAEKR...RGVRRRAPWDFDRDSAHksl16gfgCQNLTLAIGAAGCLLAYAKETQR.T...... 14 MGKLRQ...VIQRGGILITERKRADFstk27alpEMENQVAVSSLSAVIKFLELLSD.Ds..... 15 ALIEGR...RGLRRRPLWEFEIDTARqql16gfgVENASRGLCAAGCLLQYVKDTQR.T...... 16 MGKLRQ...VIQRGGILITERKRADFstk27alpEMENQVAVSSLSAVIKFLELLSD.Ds..... 17 MGKLRQ...IIQRGGILITERKKADFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 18 MGKLRQ...IIQRGGILITERKKADFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 19 ETKTVL...KGSLSSCLQEGLIPGSQfwd45ltpGEESELALSALGGIVFYLKKCLI.Dqe.... 20 ALIEGR...RGLRRRPLWEFEIDTARqql16gfgVENASRGLCAAGCLLQYVKDTQR.T...... 21 ETKTVL...KGSLSSCLQEGLIPGSQfwd45ltpGEESELALSALGGIVFYLKKCLI.Dqe.... 22 ETKTIL...KSSLSCSLQEGLIPGSQfwd47ltpGEKSELALSALGGCVFYLKKCLI.Dqe.... 23 ETKTIL...KSSLSCSLQEGLIPGSQfwd47ltpGEKSELALSALGGCVFYLKKCLI.Dqe.... 24 ETKTIL...KSSLSCSLQEGLIPGSQfwd47ltpGEKSELALSALGGCVFYLKKCLI.Dqe.... 25 ETKTIL...KSSLSCSLQEGLIPGSQfwd47ltpGEKSELALSALGGCVFYLKKCLI.Dqe.... 26 MGKLRQ...VIQRGGILITERKRIDFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 27 MGKLRQ...IVKRGGILITDRKRAEFstk27alpEMEKQVAMSALAAVMKYLELLSD.Es..... 28 EEQILS...RQMNLVLSYEKESFEDLhlld....LRLATVEQTASSKLLQYVHRTQM.R...... 29 RNILRP...GEPSEHIPKQLPTSFCYslr30gmgCEGLPLAIRAAGGLLEYIEDTQKaH...... 30 TVAQLR...ERCGATISIEDGETDEHvtiie...HLNNEDITKTFLRLYTYLKRTQK.R...... 31 RNILRP...GEPSEHIPKQLPTSFCYslr30gmgCEGLPLAIRAAGGLLEYIEDTQKaH...... 32 EPVVKQ...LQQHLRITLSEHVSWAFeyq22gfgLQGLVPAINAAGALLSYIQDKLL.L...... 33 QLQTAS...GVTRLNAWQFAADAGEKllt17gldGKEHAVAIGAAGALLNYIRLTQN.L...... 34 TVAQLR...ERCGATISIEDGETDEHvtiie...HLNNEDITKTFLRLYTYLKRTQK.R...... 35 TEMLIQ...RATNVSVRDDRIRVERMnnt34sgvINLEKPVICALAAVIRYLKEFNL.E...... 36 TEALIH...RATSVSVQDDRIRVERMdni34sgiVNLEKPVICSLAAIIKYLKEFNL.E...... 37 ISDSIL...KQFNCRITYQVDSFFAInkc19kgiGEISNSQICAIGSILEYLSLTQK.Q...... 38 TEMLIQ...RATNVSVRDDRIRVERMnnt34sgvINLEKPVICALAAVIRYLKEFNL.E...... 39 EYLQQR...NGVRRRPPWLFDADSGRrkl16gfgIENNPQATAAAGALLGYIEETQK.Q...... 40 TEMLIQ...RATNVRLKTVRKLKTPFlfl55sgvINLEKPVICALAAVIRYLKEFNL.E...... 41 TEALIH...RATSVSVQDDRIRVERMdni34sgiVNLEKPVICSLAAIIKYLKEFNL.E...... 42 QLQTAS...GVTRLNAWQFAADAGEKllt17gldGKEHAVAIGAAGALLNYIRLTQN.L...... 43 LKERFP...GVYTETISEWYFSDLEEvek12ihhFELSPLALKALAALIKYVKYTMIaE...... 44 EAVIKQ...LQQHLRITLSEYVSWAFeyq22gfgLQGLVPAINAAGALLSYIQDKLL.L...... 45 TAIVMQ...LQQHLKLTLSTYADWAFehk22gfgLKGLVPAINAAGGLLSYIQDKLL.L...... 46 PDLRPV...FDVLGRVAVPQPAVLFDsat20dgfGSFSRAELAAASAAVSYVEKTQL.Q...... 47 TAIVMQ...LQQHLKLTLSTYADWAFehk22gfgLKGLVPAINAAGGLLSYIQDKLL.L...... 48 EKLEKV...LKLHITELEEEFFEEGKeel15kafGFQDEDLSLSLGAVYRYAKATQK.S...... 49 LKERFP...GVYTETISEWYFSDLEEvek12ihhFELSPLALKALAALIKYVKYTMI.Ge..... 50 LPELAA...ILSLYPRLVRTTGADALfnp23cltLLPHSPDLAAAGALIAYLEETTR.H...... 51 SAVKTL...LDRNGVMITMPKKSGDNdll24glkELQLQLASNALKTAIKYLDLVNDaG...... 52 SVALLN...HYVSTEKTCGRVVRVQHavq36ekvKSLHSLSIICLDMAISYLMEFSL.E...... 53 EELEKV...LKVYVSELEEEFFEEGSeei15qafGFEEDTYSLPLGAVYKYAKTTQK.G...... 54 SVALLN...HYVSTEKTCGRVVRVQHavq36ekvKSLHSLSIICLDMAISYLMEFSL.E...... 55 MGKLRQ...IIQRGGILITERKKADFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 56 KSIRAI...KYCVSSSSIWNFIKPYTefw32ksyLSEKPLAISAFGALFWYLRQLKL.Dkd.... 57 ATERTI...VRQTRNPLVNNLVPLSEfwd50ateDKNGSLALSALGGAIYYLRQAFL.Desll.. 58 CKSLYD...SLERCAVMITERKKHEFkgr23rdlVSGFDLATPALGALLSFSELLSNeD...... 59 CKSLYD...SLERCAVMITERKKHEFkgr23rdlVSGFDLATPALGALLSFSELLSNeD...... 60 SAVKTL...LDRNGVMITMPKKSGDNdll24glkELQLQLASNALKTAIKYLDLVNDaG...... 61 YSEKLN...LSRFLINRVPTWHLDKDiai19slgFDEEKPYYISIFLIINHIKNNLK.N...... 62 ATERTI...VRQTRNPLVNNLVPLSEfwd50ateDKNGSLALSALGGAIYYLRQAFL.Desll.. 63 TEKFLV...AHAGPTSNVRVERASLDcfs46htiMNMPHLTVQALALTFCHLKQFGF.E...... 64 SAVKTL...LDRNGVMITMPKKSGDNdll24glkELQLQLASNALKTAIKYLDLVNDaG...... 65 LNPLQD...VISNCNVLLTEKKKADFksr23rdlLSQFDYALGPLGALLSYAELLAD.Dt..... 66 LANKIV...KFNSAPNAIFNEVKAGEefy32syyDTGKKVGFSAFGGLLYYLKWLKL.Dkn.... 67 HVAKFF...KDISCPLIHKQEYDLEDhvv12nekIQLSPSLIRLVSKLYSHMVEYNN.E...... 68 LANKIV...KFNSAPNAIFNEVKAGEefy32syyDTGKKVGFSAFGGLLYYLKWLKL.Dkn.... 69 LAKLRQ...IIDNCGVAIAERSAGEFgtk23llpQTDLKLAMGSASALIKYLGILHDpS...... 70 HIESGT...WYPELVELKKFFIKYQKmps31iqfQTFTQKELAALRNTLIYVSNHLP.D...... 71 TTHPIY...SFIQERKYFLSYVENRYqsl19sfiKYCTKLEVTAGCTLISYIADRLQ.N...... 72 HVAKFF...KDISCPLIHKQEYDLEDhvv12nekIQLSPSLIRLVSKLYSHMVEYNN.E...... 73 HIESGT...WYPELVELKKFFIKYQKmps31iqfQTFTQKELAALRNTLIYVSNHLP.D...... 74 TNGNSA...VSINTAEINRLRNIIEGcga36lvpELGLQLAMASCNALLRYLGPALL.Npdmedd 75 TTKSII...NGILFSVPVEHLLPKKQfmt41pkpSTDWQLALSAFGAIFWYLRDSLI.Dvd.... 76 MQKVIN...VIDRCGCVVTLLKNSEFsek22slpQKYSKLSMGACNALIGYLQLLSEqD...... 77 MQKVIN...VIDRCGCVVTLLKNSEFsek22slpQKYSKLSMGACNALIGYLQLLSEqD...... 78 ETQRTI...RKYASAGSVKMQLTPLSgid33ldcTMNQDVVICALGGLIGHLTRLMLhD...... 79 ETQRTI...RKYASAGSVKMQLTPLSgid33ldcTMNQDVVICALGGLIGHLTRLMLhD...... 80 TEKFLV...AHAGPTSNVRVERASLDcfs46qtiMNMPHLTVQALALTFCHLKQFGF.E...... 81 TEKFLV...AHAGPTSNVRVERASLDcfs46htiMNMPHLTVQALALTFCHLKQFGF.E...... 82 EAQKAL...RKYTLTGSTAVQLAPVPqvm34vdgLNECDVALSALGELINHLSRLKL.Ed..... 83 MTRFLG...KLASQEHREPKRPEIIFlps40siiPFDCLLTVRALGGLLKFLGRRRI.G...... 84 MTRFLG...KLASQEHREPKRPEIIFlps40siiPFDCLLTVRALGGLLKFLGRRRI.G...... 85 MTRFLG...KLASQEHREPKRPEIIFlps57tpiPLLIPSQVRALGGLLKFLGRRRI.G...... 86 KAKKIA...SMFTRMEVHNKQQLKPKsqw14ldyKDEAEKQNENIKECLQILHSNAA.D...... 87 TEMLIQ...RATNVSVRDDRIRVERMnnt34sgvINLEKPVICALAAVIRYLKEFNL.E...... 88 TTHPIY...SFIQERKYFLSYVENRYqsl19sfiKYCTKLEVTAGCTLISYIADRLQ.N...... 89 MSRAIE...RLKAMAGSHDSSMTEEDkyi9kmrfDIEAVNMIRSFGALLLFLDETRM.G...... 90 MSRAIE...RLKAMAGSHDSSMTEEDkyi9kmrfDIEAVNMIRSFGALLLFLDETRM.G...... 91 MTRFLG...KLASEEHREPKGPEIILlps40siiPFDCVLTVRALGGLLKFLSRRRI.G...... 92 MTRFLG...KLASEEHREPKGPEIILlps40siiPFDCVLTVRALGGLLKFLSRRRI.G...... 93 GNSTKL...FTLITENFKNVNFTTIQrky27lmeVQSKYYCLAAVAALLKYVEFIQN.S...... 94 GNSTKL...FTLITENFKNVNFTTIQrky27lmeVQSKYYCLAAVAALLKYVEFIQN.S...... 95 MSRAIE...RLKAMAGSHDSSMTEEDkyi9kmrfDIEAVNMIRSFGALLLFLDETRM.G...... 96 ------...-----------------........-----------------------.-...... 97 ------...-----------------........-----------------------.-...... 98 TVSKLA...TMIKFNVAETVKIEEGSrkc29ieeIIDKTFALCAASAAISYMEEIIS.Kssrnln 99 TVSKLA...TMIKFNVAETVKIEEGSrkc29ieeIIDKTFALCAASAAISYMEEIIS.Kssrnln 100 GSTKLL...GEALMTAFPEASLQSISsky27segCLRRTLALGALAVLLKYIHETRC.V...... 101 QIEKLK...YIIHSNISDKVRERFMKakv27gqvISNRKLSLAAANACIDYCVSTKMfR...... 102 SNILIN...KIYNLLIGWNLFPSEPNaki60twtENVNQANLISLLGVLQFIKDRNP.N...... 103 LQLRGHdnqTILNDILSNSKFTTTVT........LGTVGCILANHEQLGEYNDSTAS.S...... 104 LQLRGHdnqTILNDILSNSKFTTTVT........LGTVGCILANHEQLGEYNDSTAS.S...... 105 SNILIN...KIYNLLIGWNLFPSEPNaki60twtENVNQANLISLLGVLQFIKDRNP.N...... 106 ETKTIL...KSSLSCSLQEGLIPGSQfwd47ltpGEKSELALSALGGCVFYLKKCLI.Dqe.... 107 RTQQIV...RTVLGGILKEPVPGNGKhac44ltpNDNYKLALKALGQCIFFIHKCKL.Epk.... 108 ------...-----------------........-----------------------.-...... 109 ------...-----------------........-----------------------.-...... 110 ------...-----------------........-----------------------.-...... 111 ------...-----------------........-----------------------.-...... 112 ------...-----------------........-----------------------.-...... 113 MGKLRQ...IIQRGGILITERKKADFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 114 ------...-----------------........-----------------------.-...... 115 ------...-----------------........-----------------------.-...... 116 ------...-----------------........-----------------------.-...... 117 ------...-----------------........-----------------------.-...... 118 ------...-----------------........-----------------------.-...... 119 ------...-----------------........-----------------------.-...... 120 LKRQIN...MVTETITVRETLSSEIYsvn.....QTEHKLMYQATQLLLDYIHHTQK.R...... 121 ------...-----------------........-----------------------.-...... 122 MGKLRQ...IIQRGGILITERKKADFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 123 ------...-----------------........-----------------------.-...... 124 ------...-----------------........-----------------------.-...... 125 ------...-----------------........-----------------------.-...... 126 MGKLRQ...IIQRGGILITERKKADFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 127 TNGNSA...VSINTAEINRLRNIIEGcga36lvpELGLQLAMASCNALLRYLGPALL.Npdmedd 128 ------...-----------------........-----------------------.-...... 129 ------...-----------------........-----------------------.-...... 130 ------...-----------------........-----------------------.-...... 131 MGKLRQ...IIQRGGILITERKKADFstk27vlpEMENQVAVSSLSAVIKFLELLSD.Ds..... 132 ------...-----------------........-----------------------.-...... 133 ------...-----------------........--------------IKFRKEFLG.D...... 134 ------...-----------------........---------------KFRREFLD.D...... 135 ------...-----------------........-----------------------.-...... 136 ------...-----------------........-----------------------.-...... 137 ------...-----------------........-----------------------.-...... 138 ------...-----------------........-----------------------.-...... 139 YELIIY...VYSEGMLELEDTFSTIMv.......TADSDKHEIVPECVLNYF-----.-...... 140 ------...-----------------........-----------------------.-...... 141 ------...-----------------........-----------------------.-...... 142 ------...-----------------........-----------------------.-...... 143 ------...-----------------........-----------------------.-...... 144 ------...-----------------........-----------------------.-...... 145 ------...-----------------........-----------------------.-...... 146 ------...-----------------........-----------------------.-...... 147 ------...-----------------........-----------------------.-...... 148 TEMLIQ...RATNVRL----------........-----------------------.-...... 149 ------...-----------------........-----------------------.-...... 150 ------...-----------------........-----------------------.-...... 151 ------...-----------------........-----------------------.-...... 240 250 260 | | | 1 A........LSLQP....FRFYDP........GAFMRLPEATLRALE...VFE........PLRG 2 A........LSLQP....FRFYDP........GAFMRLPEATLRALE...VFE........PLRG 3 A........LSVRP....FRLYDP........GAFVRLPEASLKALE...VFE........PLRG 4 A........LSVRP....FRLYDP........GAFVRLPEASLKALE...VFE........PLRG 5 A........LSVRP....FRLYDP........GAFVRLPEASLKALE...VFE........PLRG 6 A........LSVRP....FRLYDP........GAIVRLPEASLKALE...VFE........PLRG 7 T........LPHIRs...ITMERE........QDSIIMDAATRRNLE...ITQ........NLAG 8 T........LPHIRs...ITMERE........QDSIIMDAATRRNLE...ITQ........NLAG 9 A........LPHLRg...LRHERL........DDTVILAGASRRNLE...LDV........NLSG 10 T........LPHIRs...ITMERE........QDSIIMDAATRRNLE...ITQ........NLAG 11 A........LPHIQs...ISLIQN........QDCIQLDAATRRNLE...LTQ........NLAG 12 A........LPHLRs...LRHDRL........DDTVILDGASRRNLE...LDI........NLSG 13 A........LPHLRs...LRHDRL........DDTVILDGASRRNLE...LDI........NLSG 14 N........FGQFE....LATFDF........SQYMKLDMAAVRALN...LFQ........GSVE 15 S........LPHIRs...ITMERQ........QDSIIMDAATRRNLE...ITQ........NLAG 16 N........FGQFE....LATFDF........SQYMKLDMAAVRALN...LFQ........GSVE 17 N........FGQFE....LTTFDF........SQYMKLDIAAVRALN...LFQ........GSVE 18 N........FGQFE....LTTFDF........SQYMKLDIAAVRALN...LFQ........GSVE 19 L........LSMAN....FEEYFPlds18tkaSQRMVLDAVTLNNLE...IFL........NGTN 20 S........LPHIRs...ITMERQ........QDSIIMDAATRRNLE...ITQ........NLAG 21 L........LSMAN....FEEYFPlds18tkaSQRMVLDAVTLNNLE...IFL........NGTN 22 L........LSMAN....FEEYIPlds18tkaYQRMVLDAVTLNNLE...IFL........NGTN 23 L........LSMAN....FEEYIPlds18tkaYQRMVLDAVTLNNLE...IFL........NGTN 24 L........LSMAN....FEEYIPlds18tkaYQRMVLDAVTLNNLE...IFL........NGTN 25 L........LSMAN....FEEYIPlds18tkaYQRMVLDAVTLNNLE...IFL........NGTN 26 N........FGQFE....LATFDF........SQYMKLDMAAVRALN...LFQ........GSVE 27 N........FGQFV....MTNFDL........SQYMKLDNAAVGALN...LFP........GSAE 28 E........LNHLKp...VIRYEI........KDFLQMDYATKASLD...LVE........NARS 29 V........VPIQP....LKTYGL........TDFLVLDHQTRRNLE...INQ........TVRD 30 S........LDHLQp...VQVYEL........EEAMKIDLYSKRNLE...LTE........TIRS 31 V........VPIQP....LKTYGL........TDFLVLDHQTRRNLE...INQ........TVRD 32 P........ISHLSi...PKIYGQ........HKHLLIDKASQTNLE...LLS........AIHG 33 M........PQHLDg...LSLETD........SQYIGMDAATRRNLE...ITQ........TLSG 34 S........LDHLQp...VQVYEL........EEAMKIDLYSKRNLE...LTE........TIRS 35 K........MLSKPesf.KQLSSG........MEFMRINGTTLRNLE...ILQ........NQTD 36 K........MLSKPenf.KQLSSK........MEFMTINGTTLRNLE...ILQ........NQTD 37 N........IPHLPi...PKIINF........HNYMTIDFSTRRNLE...IVT........NLQG 38 K........MLSKPesf.KQLSSG........MEFMRINGTTLRNLE...MVQ........NQTD 39 R........LPHLTs...ITMETV........GEAITMNAATRRHLE...LDT........RVDG 40 K........MLSKPesf.KQLSSG........MEFMRINGTTLRNLE...ILQ........NQTD 41 K........MLSKPenf.KQLSSK........MEFMTINGTTLRNLE...ILQ........NQTD 42 M........PQHLDg...LSLETD........SQYIGMDAATRRNLE...ITQ........TLSG 43 D........LNLKP....PLLISQ........RDYMILDSATVENLS...LIP........GDRG 44 P........ISHLSi...PKIYGQ........QKHLLIDKASQTNLE...LLS........PIHG 45 P........TKHIAi...PQTRGK........QQKLLIDTASQVNLE...LLA........PLND 46 E........RPALGi...PERESA........ASTLFIDPATRANLE...LAK........TLSG 47 P........TKHIAi...PQTRGK........QQKLLIDTASQVNLE...LLA........PLND 48 F........TPLIPk...PKPYVD........EGYVKLDLKAVKGLE...ITE........SIEG 49 D........LNLKP....PLLISQ........RDYMILDSATVENLS...WIP........GDRG 50 P........LSHVSa...ITRYHI........HDFVEIDDATRKNLE...ILQ........NLHD 51 N........LGHYE....IKQLDL........NRFVHLDSAAVAALN...IMP........KPGT 52 D........LFVASnf..YQPFDS........ISSMVLSKQALEGLE...LFV........NQTD 53 Y........TPLIPr...PKPYRD........EGFVRLDIKAIKGLE...ILE........SLEG 54 D........LFVASnf..YQPFDS........ISSMVLSKQALEGLE...LFV........NQTD 55 N........FGQFE....LTTFDF........SQYMKLDIAAVRALN...LFQ........GSVE 56 M........CSMGN....FDEYDAsqq.....STSLLMNGQTLKNLE...IFS........NSFD 57 -rfakfes.LPYCD....FSNVNE........KQHMVLDAAALENLE...IFE........NSRN 58 N........YGNFT....IRRYDI........GGFMRLDSAAMRALN...VME........SKTD 59 N........YGNFT....IRRYDI........GGFMRLDSAAMRALN...VME........SKTD 60 N........LGHYE....IKQLDL........NRFVHLDSAAVAALN...IMP........KPGT 61 L........LSNIDk...IDINND........SSYMFLDDVTQVNLE...LVK........NNND 62 -rfakfes.LPYCD....FSNVNE........KQHMVLDAAALENLE...IFE........NSRN 63 R........ILYQGas..FRSLSS........NTEMTLSANTLQQLE...VVK........NNSD 64 N........LGHYE....IKQLDL........NRFVHLDSAAVAALN...IMP........KPGT 65 N........YGNYT....IEKYNL........NCYMRLDSAAVRALN...IAE........GKTD 66 L........ISMKN....IKEYDFvks.....QHSMVLDGITLQNLE...IFS........NSFD 67 Q........VMLIPsi..YSPFAS........KIHMLLDPNSLQSLD...IFT........HDGG 68 L........ISMKN....IKEYDFvks.....QHSMVLDGITLQNLE...IFS........NSFD 69 N........FGQYQ....LYQHDL........AQFMKLDAAALKALN...LMP........GARD 70 F........SINFQi...PQRQLA........TAIMQIDSRTSTALE...LHS........TVRD 71 S........HPNIQp...PIRVSL........NEYMIIGESAMKGLE...IRS........SLYQ 72 Q........VMLIPsi..YSPFAS........KIHMLLDPNSLQSLD...IFT........HDGG 73 F........SINFQi...PQRQLA........TAIMQIDSRTSTALE...LHS........TVRD 74 -rent....SRKLH....LYHHNL........EQYMRLDIAAVRSLN...LLP........PPNG 75 M........LSMRN....VTIYNSnsm15dwnGKNLILDGTALENLN...IVP........NGRD 76 Q........VGKYE....LVEHKL........KEFMKLDASAIKALN...LFPqgp20tsa---- 77 Q........VGKYE....LVEHKL........KEFMKLDASAIKALN...LFPqgp20tsa---- 78 A........LKNGEv...LPYHVY........KTCLRMDGQTLVNLE...IFI........NNFN 79 A........LKNGEv...LPYHVY........KTCLRMDGQTLVNLE...IFI........NNFN 80 R........ILYQGas..FRSLSS........NTEMTLSANTLQQLE...VVK........NNSD 81 R........ILYQGas..FRSLSS........NTEMTLSANTLQQLE...VVK........NNSD 82 V........LKHGDi...FPYQVY........RGCLRIDGQTMVNLE...IFN........NSCD 83 VeledynvsVPILG....FKKFML........THLVNIDQDTYSVLQ...IFKses11kva---- 84 VeledynvsVPILG....FKKFML........THLVNIDQDTYSVLQ...IFKses11kva---- 85 VeledynvsVPILG....FKKFML........THLVNIDQDTYSVLQ...IFKses11kva---- 86 E........YSISEkys.IFNYGT........HGNMLIDSCAVEALE...LFQ........LNYN 87 K........MLSKPesf.KQLSSG........MEFMRINGTTLRNLE...MVQ........NQTD 88 S........HPNIQp...PIRVSL........NEYMIIGESAMKGLE...IRS........SLYQ 89 VtddplsvtSPIKS....IKTFTL........GNLVEIDFNTIQALD...ILP........KETE 90 VtddplsvtSPIKS....IKTFTL........GNLVEIDFNTIQALD...ILP........KETE 91 VeledydvgVPILG....FKKFVL........THLVSIDQDTYSVLQ...IFKses11kva---- 92 VeledydvgVPILG....FKKFVL........THLVSIDQDTYSVLQ...IFKses11kva---- 93 V........YAPKSlk..ICFQGS........EQTAMIDSSSAQNLE...LLI........NNQD 94 V........YAPKSlk..ICFQGS........EQTAMIDSSSAQNLE...LLI........NNQD 95 VtddplsvtSPIKS....IKTFTL........GNLVEIDFNTIQALD...ILP........KETE 96 -........-----....------........------DTAALENLE...LLE........NTRT 97 -........-----....------........---------------...---........---- 98 A........FRKLR....IQFEGT........ENTMLIDSKTVRGLE...LVE........NKLD 99 A........FRKLR....IQFEGT........ENTMLIDSKTVRGLE...LVE........NKLD 100 F........FRVKSlr..IKEMGV........NDTCMIDFVSWESLE...IVD........ADDA 101 V........TNKIR....LKYCMC........ENTMLIDTCTVRDLE...LVD........SLSE 102 L........IKNLQlpecYNSVVS........PLNLILCNRAEYQLD...LLS........KRGK 103 Nmvt12afeDVIHG....IRYIDI........RDRMVLDENTISALH...IFP........TAHK 104 Nmvt12afeDVIHG....IRYIDI........RDRMVLDENTISALH...IFP........TAHK 105 L........IKNLQlpecYNSVVS........PLNLILCNRAEYQLD...LLS........KRGK 106 L........LSMAN....FEEYIPlds18tkaYQRMVLDAVTLNNLE...IFL........NGTN 107 V........LPMAR....YQLYVPpdq16tlrRSHMVLDATTLSNLR...II-........--GE 108 -........-----....------........---------------...---........---- 109 -........-----....------........---------------...---........---- 110 -........-----....------........---------------...---........---- 111 -........-----....------........---------------...---........---- 112 -........-----....------........---------------...---........---- 113 N........FGQFE....LTTFDF........SQYMKLDIAAVRALN...LFQ........GSVE 114 -........-----....------........---------------...---........---- 115 -........-----....------........---MAFDSRALSALD...FPRit......---- 116 -........-----....------........---------------...---........---- 117 -........-----....------........---------------...---........---- 118 -........-----....------........---------------...---........---- 119 -........-----....------........---------------...---........---- 120 D........LSHIEd...VVQYAA........IDYMKMDFYAKRNLE...LTE........SIRL 121 -........-----....------........---------------...---........---- 122 N........FGQFE....LTTFDF........SQYMKLDIAAVRALN...LFQ........GSVE 123 -........-----....------........---------------...---........---- 124 -........-----....------........---------------...---........---- 125 -........-----....------........---------------...---........---- 126 N........FGQFE....LTTFDF........SQYMKLDIAAVRALN...LFQ........GSVE 127 -rent....SRKLH....LYHHNL........EQYMRLDIAAVRSLN...LLP........PPNG 128 -........-----....------........---------------...---........---- 129 -........-----....------........---------------...---........---- 130 -........-----....------........---------------...---........---- 131 N........FGQFE....LTTFDF........SQYMKLDIAAVRALN...LFQ........GSVE 132 -........-----....------........---------------...---........---- 133 R........LLVVS....EDEVEE........AEKLGLCMVSTEPIEgydIVL........STIG 134 R........VLIVS....EDEVEE........AEKLNLCIVSTEPIEgydIVL........STIG 135 -........-----....------........---------------...---........---- 136 -........-----....------........---------------...---........---- 137 -........-----....------........---------------...---........---- 138 -........-----....------........---------------...---........---- 139 -........-----....------........----------RKNLE...LFR........NAL- 140 -........-----....------........---------------...---........---- 141 -........-----....------........---------------...---........---- 142 -........-----....------........---------------...---........---- 143 -........-----....------........---------------...---........---- 144 -........-----....------........---------------...---........---- 145 -........-----....------........---------------...---........---- 146 -........-----....------........---------------...---........---- 147 -........-----....------........---------------...---........---- 148 -........-----....------........---------------...---........---- 149 -........-----....------........---------------...---........---- 150 -........-----....------........---------------...---........---- 151 -........-----....------........---------------...---........---- 270 280 290 300 310 | | | | | 1 Q........DTLFSVLDETRT.APGRRLLQSWLRHPLLDRGPLEARLDRV.EGF........V.. 2 Q........DTLFSVLDETRT.APGRRLLQSWLRHPLLDRGPLEARLDRV.EGF........V.. 3 Q........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV.ERF........V.. 4 Q........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV.ERF........V.. 5 Q........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV.ERF........V.. 6 Q........DTLFGVLDETRT.APGRRLLQAWLRHPLLERGPLEARLDRV.ERF........V.. 7 Gae......NTLASVLDCTVT.PMGSRMLKRWLHMPVRDTRVLLERQQTI.GAL........Q.. 8 Gae......NTLASVLDCTVT.PMGSRMLKRWLHMPVRHTRVLLERQQTI.GAL........Q.. 9 Grd......NTLQSVIDRCQT.AMGSRLLGRWLNRPLRDRAVLEARQDTV.ACL........L.. 10 Gae......NTLASVLDCTVT.PMGSRMLKRWLHMPVRDTRVLLERQQTI.GAL........Q.. 11 Gte......NTLASVLDKCVT.PMGSRLLKRWIHQPVRDVEKLKQRQQSI.AEI........L.. 12 Gre......NTLQSVVDRCQT.AMASRLMSRWLNRPLRDRAVLEARQESI.ACL........L.. 13 Gre......NTLQSVVDRCQT.AMASRLMSRWLNRPLRDRAVLEARQESI.ACL........L.. 14 Dttgs....QSLAALLNKCKT.AQGQRLVNQWIKQPLMDRNRIEERLNLV.EAF........V.. 15 Gve......NTLAAVLDCTVT.PMGSRMLKRWLHMPVRNTDILRERQQTI.GAL........Q.. 16 Dttgs....QSLAALLNKCKT.AQGQRLVNQWIKQPLMDRNRIEERLNLV.EAF........V.. 17 Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEERLNLV.EAF........V.. 18 Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEERLNLV.EAF........V.. 19 Gste.....GTLLERLDTCHT.PFGKRLLKQWLCAPLCSPSAISDRLDAV.EDL........M.. 20 Gve......NTLAAVLDCTVT.PMGSRMLKRWLHMPVRNTDILRERQQTI.GAL........Q.. 21 Gste.....GNLLERLDTCHT.PFGKRLLKQWLCAPLCSPSAISDRLDAV.EDL........M.. 22 Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDRLDAI.EDL........M.. 23 Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDRLDAI.EDL........M.. 24 Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDRLDAI.EDL........M.. 25 Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDRLDAI.EDL........M.. 26 Dttgs....QSLAAFLNKCKT.AQGQRLVSQWIKQPLMDKNRIEERLNLV.EAF........V.. 27 Dtsgt....QSLAGLLNKCKT.PQGQRLVNQWIKQPLMDKNRVEERLNLV.EAF........V.. 28 Gkkq.....GSLFWLLDETKT.AMGMRLLRSWIHRPLIDKERIVQRQEVV.QVF........L.. 29 Gsfh.....GSLLWALDRTST.TMGSRALRRWLLQPLLDLKGIQARQDTI.QEL........Y.. 30 Knkk.....GSLLWLLDETKT.AMGGRLLKQWIDRPLIRVNQIEERQEMV.ETL........M.. 31 Gsfh.....GSLLWALDRTST.TMGSRALRRWLLQPLLDLKGIQARQDTI.QEL........Y.. 32 Ehgk.....GSLLQVMERTST.PMGGRLLRNTLVNPFYDLKEITLRQDSV.EFF........L.. 33 Kks......PTLMSTLDLCAT.HMGSRLLALWLHHPLRNRAHIRARQEAV.AAL........E.. 34 Knkk.....GSLLWLLDETKT.AMGGRLLKQWIDRPLIRVNQIEERQEMV.ETL........M.. 35 Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQPLLKLREINARLDAVsDVL........H.. 36 Mktk.....GSLLWVLDHTKT.SFGRRKLKKWVTQPLLKLREINARLDAVsEVL........H.. 37 Nly......GSVLNTLNHTVT.TQGGRLLYHFLSSPLTNIAKINHRLNIT.EFF........Y.. 38 Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQPLLKLREINARLDAVsDVL........H.. 39 Esr......HTLLGVLDSTVT.PMGGRLLRRWLHRPLRLREVVRQRHAAV.GSM........I.. 40 Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQPLLKLREINARLDAVsDVL........H.. 41 Mktk.....GSLLWVLDHTKT.SFGRRKLKKWVTQPLLKLREINARLDAVsEVL........H.. 42 Kks......PTLMSTLDLCAT.HMGSRLLALWLHHPLRNRAHIRARQEAV.AAL........E.. 43 Kn.......--LFDVLNNTET.PMGARLLKKWILHPLVDRKQIEERLKAV.ERL........V.. 44 Ehgk.....GSLLQVMERTST.PMGGRLLRNTLINPFYDLKEITLRQDSV.EFF........L.. 45 Pqgk.....NSLLRIMDHTST.PMGGRLLRQILISPFYNPKEILVRQDAV.EFF........L.. 46 Srd......GSLLKSLDRTMT.SGGARLLAERLMSPLTDPERINQRLDSI.EVL........A.. 47 Pqgk.....NSLLRIMDHTST.PMGGRLLRQILISPFYNPKEILVRQDAV.EFF........L.. 48 Rkd......LSLFKVVDRTLT.GMGRRRLRFRLLNPFRSIERIRKVQEAV.EEL........I.. 49 Kn.......--LFDVLNNTET.PMGARLGKKWILHPLVDRKQIEERLKAV.ERL........V.. 50 Stha.....HSLFETLNYTHT.AMGTRLLRYWLHHPLRSQEEIQKRLSAV.VFF........H.. 51 HpsmpsyrwQSVLGVLDHCRT.PQGHRLMGQWVKQPLRSRNILNDRHNIV.QCL........L.. 52 Htpv.....GSLFWVLDRTYT.RFGQRMLQRWLQKPLVDKENIIERLDAV.EEL........Af. 53 Rkd......ISLFKVIDRTLT.GMGRRRLKFRLLSPFRSREKIERIQEGV.QEL........K.. 54 Htpv.....GSLFWVLDRTYT.RFGQRMLQRWLQKPLVDKENIIERLDAV.EEL........Af. 55 Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEERLNLV.EAF........V.. 56 Ggse.....GTLFHLLCRCVT.PFGKRLFHTWLCHPLRSGTAINARLDVV.ELI........A.. 57 Ggys.....GTLYAQLNQCIT.ASGKRLLKTWLARPLYNTELIKERQDAV.AIL........Rg. 58 Ankn.....FSLFGLMNRTCTaGMGKRLLHMWLKQPLVDLNEIKTRLDIV.QCF........V.. 59 Ankn.....FSLFGLMNRTCTaGMGKRLLHMWLKQPLVDLNEIKTRLDIV.QCF........V.. 60 HpsmpsyrwQSVLGVLDHCRT.PQGHRLMGQWVKQPLRSRNILNDRHNIV.QCL........L.. 61 Fssq.....YSLYSVLNDCKT.AMGKRLLREFILNPILNISEINTRLDHV.EFF........C.. 62 Ggys.....GTLYAQLNQCIT.ASGKRLLKTWLARPLYNTELIKERQDAV.AIL........Rg. 63 Gses.....GSLFHNMNHTLT.VYGSRLLRHWVTHPLCDRNLISARLDAV.SEIsac27ivsP.. 64 HpsmpsyrwQSVLGVLDHCRT.PQGHRLMGQWVKQPLRSRNILNDRHNIV.QCL........L.. 65 Vnkn.....FSLFGLMNRTCTvGMGKRLLNRWLKQPLLDVNEINNRLDMV.QAF........V.. 66 Gsdk.....GTLFKLFNRAIT.PMGKRMMKKWLMHPLLRKNDIESRLDSV.DSL........L.. 67 K........GSLFWLLDHTRT.SFGLRMLREWILKPLVDVHQIEERLDAI.ECI........Tse 68 Gsdk.....GTLFKLFNRAIT.PMGKRMMKKWLMHPLLRKNDIESRLDSV.DSL........L.. 69 Gakn.....MSLYGLLNHCKT.PVGSRLLSQWLKQPLMNAEEIEKRQQLV.EAF........A.. 70 Nnkk.....GSLLSSIRRTVT.PSGTRLLSQWLSGPSLDLKEIKKRQKIV.AFF........K.. 71 Nryt.....GSLLHAINKTVT.KSGSRLLTRRLCAPSTNIVEINNRLDLV.EKF........K.. 72 K........GSLFWLLDHTRT.SFGLRMLREWILKPLVDVHQIEERLDAI.ECI........Tse 73 Nnkk.....GSLLSSIRRTVT.PSGTRLLSQWLSGPSLDLKEIKKRQKIV.AFF........K.. 74 Nahkt....MSLYGLLNHCRT.AMGARNLRRWIVQPLLDAKSIERRHDLV.SAL........V.. 75 Shl......TSLYYVINKCST.PFGRRLLRSWLLQPTCDPKKLEQRQKAI.KWL........Vsp 76 -gnsgkv..TSLFQLLNHCKT.NAGVRLLNEWLKQPLTNIDEINKRHDLV.DYL........I.. 77 -gnsgkv..TSLFQLLNHCKT.NAGVRLLNEWLKQPLTNIDEINKRHDLV.DYL........I.. 78 Ggss.....GTLYKHLNHCVT.ASGKRMLRRWICHPLKDIDAINKRLDVV.EGF........I.. 79 Ggss.....GTLYKHLNHCVT.ASGKRMLRRWICHPLKDIDAINKRLDVV.EGF........I.. 80 Gses.....GSLFHNMNHTLT.VYGSRLLRHWVTHPLCDRNLISARLDAV.SEIsac27ivsP.. 81 Gses.....GSLFHNMNHTLT.VYGSRLLRHWVTHPLCDRNLISARLDAV.SEIsac27ivsP.. 82 Gvlq.....GPLNKYLENCVS.PTGKRLLRNWICHPLKDVESINKRLDVV.EEF........T.. 83 -sglkeg..LSLFGILNRCHC.KWGEKLLRLWFTRPTHDLGELSSRLDVI.QFF........Llp 84 -sglkeg..LSLFGILNRCHC.KWGEKLLRLWFTRPTHDLGELSSRLDVI.QFF........Llp 85 -sglkeg..LSLFGILNRCHC.KWGEKLLRLWFTRPTHDLGELSSRLDVI.QFF........Llp 86 Yleksnn..LTLYNVLNKCKT.LPGEKLLRDWLSRPLCQIDHINERLDIV.EAL........F.. 87 Mktk.....GSLLWVLDHTKT.SFGRRKLKNWVTQPLLKLREINARLDAVsDVL........H.. 88 Nryt.....GSLLHAINKTVT.KSGSRLLTRRLCAPSTNIVEINNRLDLV.EKF........K.. 89 Nkktfgqg.RSLYQLMDKCRS.TVGKKCLRKWFRNPTTDRDDLVSRQKCV.HYF........K.. 90 Nkktfgqg.RSLYQLMDKCRS.TVGKKCLRKWFRNPTTDRDDLVSRQKCV.HYF........K.. 91 -sglkeg..LSLFGILNRCRC.KWGQKLLRLWFTRPTRELRELNSRLDVI.QFF........Lmp 92 -sglkeg..LSLFGILNRCRC.KWGQKLLRLWFTRPTRELRELNSRLDVI.QFF........Lmp 93 Yrnn.....HTLFGVLNYTKT.PGGSRRLRSNILEPLVDIETINMRLDCV.QEL........L.. 94 Yrnn.....HTLFGVLNYTKT.PGGSRRLRSNILEPLVDIETINMRLDCV.QEL........L.. 95 Nkktfgqg.RSLYQLMDKCRS.TVGKKCLRKWFRNPTTDRDDLVSRQKCV.HYFkqviifk.V.. 96 Ggls.....GTLYAQLNHCVT.GFGKRLLKRWIAKPLYDCREILRRQSAV.ATF........K.. 97 -........------------.----------------------------.---........-.. 98 Kng......ISLWKFLDTTST.KMGQRSLRNSILQPLTDRGSIEMRLEAL.EEL........K.. 99 Kng......ISLWKFLDTTST.KMGQRSLRNSILQPLTDRGSIEMRLEAL.EEL........K.. 100 Skar10kqkRTLMSVLNHTVT.TNGYRLLRSSVLQPSTDVYLIQSRQEAI.EEL........I.. 101 Tg.......TTLYSFLNCCLT.KMGMRILRTSILQPSTHENSIILRSESL.QEL........I.. 102 L........GGLLNLIDYCST.AMGKALLKFRLLNPITDYSELNLRYKDI.SIF........K.. 103 Lghd10ngfFSVFELFNQVSS.DYARRILKSWLINPLTNKKRIETRYSII.RTL........Ldk 104 Lghd10ngfFSVFELFNQVSS.DYARRILKSWLINPLTNKKRIETRYSII.RTL........Ldk 105 L........GGLLNLIDYCST.AMGKRLLKFRLLNPITDYSELNLRYKDI.SIF........K.. 106 Gste.....GTLLERVDTCHT.PFGKRLLKQWLCAPLCNHYAINDRLDAI.EDL........M.. 107 E........HSLLSTLDHCCT.KFGKRLLHHWLCAPSCDVSVIKERQDAI.GEL........I.. 108 -........-----VIGHAAS.SLGKEMLLE--LKPSASIDEIKKQLDEV.DEA........S.. 109 -........------------.------------KPYTNKEKVKEEIELS.KAF........F.. 110 -........------------.----------------------------.---........-.. 111 -........----------LS.DLGRKHLDT--LKPTVNP---WDELELV.EEL........L.. 112 -........------------.----------------------------.---........-.. 113 Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEERLNLV.EAF........V.. 114 -........------------.-------------------ELLAQTQAV.ESI........E.. 115 -........---AALADRAAT.SLGRE--RALALRPSDDAYRIAQELDEV.E--........-.. 116 -........------------.----------------ERDTIALENDLK.QTF........T.. 117 -........------------.----------------ERGSIALENDLK.QAF........T.. 118 -........------------.----------------------------.---........-.. 119 -........------------.----------------------------.---........-.. 120 Kskk.....GTLLWLMDETKT.PMGARRLKQWIDRPLISKEQIEARLDIV.DEF........S.. 121 -........------------.---------------------LKTKESL.EKI........F.. 122 Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEERLNLV.EAF........V.. 123 -........------------.----------------------------.---........-.. 124 -........------------.------------------KEIFLQGDSN.LHF........K.. 125 -........------------.------------------KEIFLQGDSN.LHF........K.. 126 Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEERLNLV.EAF........V.. 127 Nahkt....MSLYGLLNHCRT.AMGARNLRRWIVQPLLDAKSIERRHDLV.SAL........V.. 128 -........------------.----------------------------.---........-.. 129 -........------------.----------------------------.---........-.. 130 -........------------.----------------------------.---........-.. 131 Dttgs....QSLAALLNKCKT.PQGQRLVNQWIKQPLMDKNRIEERLNLV.EAF........V.. 132 -........------------.----------------------------.---........-.. 133 Ygidv....------------.-----ELKPYEIAPELYIKPLWESRDVL.EAL........A.. 134 Ygiev....------------.-----ELKPYEIAPELYVKPLWENRGVL.EAL........A.. 135 -........------------.----------------------------.---........-.. 136 -........------------.----------------------------.---........-.. 137 -........------------.----------------------------.---........-.. 138 -........------------.----------------------------.---........-.. 139 -........------------.-------------------EIKRILGME.TCL........H.. 140 -........------------.----------------------------.---........-.. 141 -........------------.----------------------------.---........-.. 142 -........------------.----------------------------.---........-.. 143 -........------------.----------------------------.---........-.. 144 -........------------.----------------------------.---........-.. 145 -........------------.----------------------------.---........-.. 146 -........------------.----------------------------.---........-.. 147 -........------------.----------------------------.---........-.. 148 -........------------.----------------------------.---........-.. 149 -........------------.----------------------------.---........-.. 150 -........------------.----------------------------.---........-.. 151 -........------------.----------------------------.---........-.. 320 330 340 350 360 | | | | | 1 .REG..ALREGVR...RLLYRLADLERLATRLE........LGRA..SPKDLGALRR.SLQILPE 2 .REG..ALREGVR...RLLYRLADLERLATRLE........LGRA..SPKDLGALRR.SLQILPE 3 .REG..ALREGVR...RLLFRLADLERLATRLE........LSRA..SPRDLAALRR.SLEILPE 4 .REG..ALREGVR...RLLFRLADLERLATRLE........LSRA..SPRDLAALRR.SLEILPE 5 .REG..ALREGVR...RLLFRLADLERLATRLE........LSRA..SPRDLAALRR.SLEILPE 6 .REG..ALREGVR...RLLFRLADLERLATRLE........LSRA..SPRDLAALRRrSLEILPE 7 .---..DFTAELQ...PVLRQVGDLERILARLA........LRTA..RPRDLARMRH.AFQQLPE 8 .---..DFTAELQ...PVLRQVGDLERILARLA........LRTA..RPRDLARMRH.AFQQLPE 9 .QDY..R-FESLQ...PQLKEIGDVERILARIG........LRNA..RPRDLARLRD.ALAALPQ 10 .---..DFTAGLQ...PVLRQVGDLERILARLA........LRTA..RPRDLARMRH.AFQQLPE 11 .N-F..DLVDELQ...PYLQLVGDMERILARVA........LRSA..RPRDLTRLRT.ALEQIPA 12 .ERY..R-FENLQ...PQLKEIGDLERILARIG........LRNA..RPRDLARLRD.ALAALPD 13 .ERY..R-FENLQ...PQLKEIGDLERILARIG........LRNA..RPRDLARLRD.ALAALPD 14 .EDS..ELRQSLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPS 15 .D--..-TVSELQ...PVLRQVGDLERTPCASGaaqpsa..RSRP..NA-------S.RLPAAAE 16 .EDS..ELRQSLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPS 17 .EDA..ELRQTLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPN 18 .EDA..ELRQTLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPN 19 .AVP..DKVTEVA...DLLKKLPDLERLLSKIHnvg23ettYSKK..KIIDFLSALE.GFKVMCK 20 .D--..-TVSELQ...PVLRQVGDLERTPCASGaaqpsa..---R..SRPNASRLPA.AAELHAQ 21 .AVP..YKVTEVA...DLLKKLPDLERLLSKIHnvg23ettYSKK..KIIDFLSALE.GFKVMCK 22 .VVP..DKISEVV...ELLKKLPDLERLLSKIHnvg23ettYSKK..KIIDFLSALE.GFKVMCK 23 .VVP..DKISEVV...ELLKKLPDLERLLSKIHnvg23ettYSKK..KIIDFLSALE.GFKVMCK 24 .VVP..DKISEVV...ELLKKLPDLERLLSKIHnvg23ettYSKK..KIIDFLSALE.GFKVMCK 25 .VVP..DKISEVV...ELLKKLPDLERLLSKIHnvg23ettYSKK..KIIDFLSALE.GFKVMCK 26 .EDS..ELRRALQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GVKQLPN 27 .MDV..ELRQCLQe..DLLRRFPDLNRLAKKFQ........RQTA..NLQDCYRLYQ.AVNHLPT 28 .DHF..FERSDLT...DSLKGVYDIERLASRVS........FGKT..NPKDLLQLAT.TLSSVPR 29 .HHP..ALRQDLR...QLLRQIYDLERLTGRIG........ANTA..SARDVYGLAS.SLVRLTD 30 .SHF..FEREDLR...ERLKEVYDLERLAGRVA........FGNV..NARDLIQLKE.SLKQVPG 31 .HHP..ALRQDLR...QLLRQIYDLERLTGRIG........ANTA..SARDVYGLAS.SLVRLTD 32 .KQE..PLRKTLK...RHLSCVRDLERLATKIS........TTLA..SPKDIGMLRD.SLLSCMH 33 .SQY..KPLQ---...CRLKNIADIERIAARIA........VGNA..RPRDLASLRD.SLFELAQ 34 .SHF..FEREDLR...ERLKEVYDLERLAGRVA........FGNV..NARDLIQLKE.SLKQVPG 35 .SES..SVFEQIE...NLLRKLPDVERGLCSIY........HKKC..STQEFFLIVK.SLCQLKS 36 .SES..SVFGQIE...NHLRKLPDIERGLCSIY........HKKC..STQEFFLIVK.TLYHLKS 37 .SNL..GIVTRIR...ELLKNTSDIERCLTRIT........MNRS..SGRDLLSIKY.TLETAKT 38 .SES..SVFEQIE...NLLRKLPDVERGLCSIY........HKKC..STQEFFLIVK.SLCQLKS 39 .D-R..DLDNKLM...ETFRRLGDMERILTRVA........LRSA..RPRDISTLRD.SLSLLPR 40 .SES..SVFEQIE...NLLRKLPDVERGLCSIY........HKKC..STQEFFLIVK.SLCQLKS 41 .SES..SVFGQIE...NHLRKLPDIGRGLCSIY........HKKC..STQEFFLIVK.TLYHLKS 42 .SQY..KPLQ---...CRLKSIADIERIAARIA........VGNA..RPRDLAALRD.SLFALSE 43 .NDR..VSLEEMR...NLLSNVRDVERIVSRVE........YNRS..VPRDLVALRE.TLEIIPK 44 .QQA..DLRKILK...RQLSCVRDLERLATKIS........TSLA..TPKDIGTLRD.SLLSCTH 45 .RQV..TLRKNIK...TYLCQVRDIERLMTKVT........TGLA..GPRDIGTLRD.SFSAGAQ 46 .DQP..RFTTDVR...DALRRAPDMPRALSRLA........LGRG..GPRDLGAIQA.GMRAAAA 47 .RQV..TLRKNIK...TYLCQVRDIERLMTKVT........TGLA..GPRDIGTLRD.SFSAGAQ 48 .NKR..EVLNEIR...KTLEGMSDLERLVSRIS........SNMA..SPRELIHLKN.SLRKAEE 49 .NDR..VSLEEMR...NLLSNVRDVERIVSRVE........YNRS..VPRDLVALRE.TLEIIPK 50 .HRP..HILKTLR...ATLSCVRDVERLVARVA........LEKA..HGRDLLALKE.SLRAILT 51 .ESP..DTMETLSl..DYLKRIPDILMLTKKLM........RRKA..NLQDLFRIYQ.VILRTPK 52 .NSN..SQVQAIR...KMLYRLPDLEKGLSRIYyqr13afsKNSY..SCFKSALLRR.LIQQLPS 53 .ENR..EALLKIR...QILEGMADLERLVSKIS........SNMA..TPRELVYLKN.SLKKVEE 54 .NSN..SQVQAIR...KMLYRLPDLEKGLSRIYyqr13afsKNSY..SCFKSALLRR.LIQQLPS 55 .EDA..ELRQTLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPN 56 .DNP..VIRDTIW...GFLHKLPDLERLISRVH........AGRS..KPADFVRVLE.GFQRINS 57 .ENL..PYSLEFR...KSLSRLPDMERLIARMFssi15vvlYEDT..AKKQVQEFIS.TLRGCET 58 .EEA..GLRQDLR...QHLKRISDVERLLRSLE........RRRG..GLQHIIKLYQ.STIRLPF 59 .EEA..GLRQDLR...QHLKRISDVERLLRSLE........RRRG..GLQHIIKLYQ.SAIRLPF 60 .ESP..DTMETLSl..DYLKRIPDILMLTKKLM........RRKA..NLQDLFRIYQ.VILRTPK 61 .KNI..SLTVTLR...ETFINIWDIERIISRIQ........MKRY..IKKDFLFIEK.ALSVFFT 62 .ENL..PYSLEFR...KSLSRLPDMERLIARMFssi15vvlYEDT..AKKQVQEFIS.TLRGCET 63 .EFY..LVLSSVL...TAMSRSSDIQRGITRIF........HRTA..KATEFIAVME.AILLAGK 64 .ESP..DTMETLSl..DYLKRLKQMVE------........----..----------.------- 65 .EDP..ELRQGLR...QQLKRISDIDRLTHSLR........KKSA..NLQPVVKLYQ.SCSRIPY 66 .QDI..TLREQLE...ITFSKLPDLERMLARIH........SRTI..KVKDFEKVIT.AFETIIE 67 iNNS..IFFESLN...QMLNHTPDLLRTLNRIM........YGTT..SRKEVYFYLK.QITSFVD 68 .QDI..TLREQLE...ITFSKLPDLERMLARIH........SRTI..KVKDFEKVIT.AFETIIE 69 .NDT..ELRQSMQe..EHLRSIPDLYRLSKRFQ........RGKA..TLEDVVRAYQ.VVIRLPG 70 .DNR..DITENLR...TMLKKVNDLSRILQKFS........FGRG..EALELIQMAR.SLEVSRE 71 .LLP..ELCSKVI...NLLKKSNDTHRILQHLL........MGRG..NSYDLLKMAD.NFSITKE 72 iNNS..IFFESLN...QMLNHTPDLLRTLNRIM........YGTT..SRKEVYFYLK.QITSFVD 73 .DNR..DITETLR...TMLKKVNDLSRILQKFS........FGRG..EALELIQMAR.SLEVSRE 74 .EDA..EARQLLLdddHLLRSIPDIPKLCRRLT........RGSA..SLEDVVRIYQ.MAKALPK 75 .DAS..SFMTTAT...ATLKKIPDLDRLLQKIHtig23tikTNQK..KIAELLAAID.GFKLCNK 76 .DQI..ELRQMLTs..EYLPMIPDIRRLTKKLN........-KRG..NLEDVLKIYQ.FSKRIPE 77 .DQI..ELRQMLTs..EYLPMIPDIRRLTKKLN........-KRG..NLEDVLKIYQ.FSKRIPE 78 .QNC..GLGPTTL...GYLQKIPDLERLLGQVRst......VGLS..SLLQLPFIGE.------- 79 .QNC..GLGPTTL...GYLQKIPDLERLLGQVRst......VGLS..SLLQLPFIGE.------- 80 .EFY..LVLSSVL...TAMSRSSDIQRGITRIF........HRTA..KATEVKIWPV.LCPLMYV 81 .EFY..LVLSSVL...TAMSRSSDIQRGITRIF........HRTA..KATEVKIWPV.LCPLMYV 82 .ANS..ESMQITG...QYLHKLPDLERLLGRIK........SSVR..SSASVLPALL.GKKVL-- 83 .QNL..DMAQMLH...RLLGHIKNVPLILKRMK........LSHT..KVSDWQVLYK.TVYSALG 84 .QNL..DMAQMLH...RLLGHIKNVPLILKRMK........LSHT..KVSDWQVLYK.TVYSALG 85 .QNL..DMAQMLH...RLLGHIKNVPLILKRMK........LSHT..KVSDWQVLYK.TVYSALG 86 .ENQ..TIRQKLRd..SILARMPDCSQLARRLMrkc16aatLLET..VEMQLIQLSE.AEQFAPS 87 .SES..SVFEQIE...NLLRKLPDVERGLCSIY........HKKC..STQEFFLIVK.SLCQLKS 88 .LLP..ELCSKVI...NLLKKSNDTHRILQHLL........MGRG..NSYDLLKMAD.NFSITKE 89 .QDWnaEVTAKLS...SILGRVKALNSVFQKFQ........SGTA..QLIHWECFVS.TVNALVE 90 .QDWnaEVTAKLS...SILGRVKALNSVFQKFQ........SGTA..QLIHWECFVS.TVNALVE 91 .QNL..DMAQMLH...RLLSHIKNVPLILKRMK........LSHT..KVSDWQVLYK.TVYSALG 92 .QNL..DMAQMLH...RLLSHIKNVPLILKRMK........LSHT..KVSDWQVLYK.TVYSALG 93 .QDE..ELFFGLQ...SVISRFLDTEQLLSVLVqip9dtvnAAES..KITNLIYLKH.TLELVDP 94 .QDE..ELFFGLQ...SVISRFLDTEQLLSVLVqip9dtvnAAES..KITNLIYLKH.TLELVDP 95 .EYR..NLWEIFL...NHSKFSPDSEYLSEKIFlkk96kfqSGTA..QLIHWECFVS.TVNALVE 96 .GVGq.DCAAQFR...KDLSRLPDMERLLARLFssc14vvlYEDA..SKKLLQQFTS.ALCGCQQ 97 .---..----DVS...PVMIKVVDAAVQKARIG........LRNA..RPRDLARLRD.ALGALPE 98 .AND..DLLQKLR...LEMKSLPDLDKLFSRLLcinhsai.KPDQ..RINYVLLLKE.TLQSVKS 99 .AND..DLLQKLR...LEMKSLPDLDKLFSRLLcinhsai.KPDQ..RINYVLLLKE.TLQSVKS 100 .GKP..QLKDKLR...RTLSRAHELDRVIAMCIqts9wtvrESEA..KINQIIKLMH.TLKVIQG 101 .NDE..DALISIR...SSLKHTCDLEKVFSTFLeprgll..SQEQ..EINNIILLKT.VLQNTFV 102 .RLL..NQKIFDN...SELKCIKDLSSLHRQWAicass...DTTL..PPKKLSQIYH.SYLFACQ 103 .QNA..IIFSDLS...QSIKRCPDAFGFINQLR........SGKS..TLGTWSKVAS.FLEKGIA 104 .QNA..IIFSDLS...QSIKRCPDAFGFINQLR........SGKS..TLGTWSKVAS.FLEKGIA 105 .RLL..NQKIFDN...SELKCIKDLSSLHRQWAicass...DTTL..PPKKLSQIYH.SYLFACQ 106 .VVP..DKISEVV...ELLKKLPDLERLLSKIHnvg23ettYSKK..KIIDFLSALE.GFKVMCK 107 .RMP..TELQEVR...ALLAPMPDFERNLAQIHlfg24eklYNKQ..KLQGFMAVLK.GFNDLTK 108 .DII..RLRG--Q...APFGGLVDIRGALRRAE........IGSVl.SPSEFTEISG.LLYAVKQ 109 .DIA..ENVR---...--LFEFEDIRELLKKAK........LQGAilGVEDILKILN.VINLTKE 110 .---..-------...-----------------........----..----------.------- 111 .NYF..NRWGE--...PPIKGLNDISQEVEKVK........SGSPl.EPWELLRVSV.FLEGCDI 112 .---..-------...-----------------........----..----------.------- 113 .EDA..ELRQTLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPN 114 .NSP..ES----N...WHFKGIADITEPLARVE........RGGLv.TGLELLAIAG.TLAGVRR 115 .---..DALFGVS...LSLGGIHDIRDIHARAG........EGRVl.SGQDLLNAAY.SLDGAMT 116 .YLN..EVDAIGL...PTPKSVKESDLIIIKLTk.......LGTL..HLDEIFEIVK.RLHYIVV 117 .YLN..EVDAIGL...PAPKSVKESDLIVVKLTk.......LGTL..HLDEIYEIVK.RLRYIVV 118 .---..-------...-----------------........----..----------.------- 119 .---..-------...-----------------........--VL..NVSELNLIKR.LIQVQNQ 120 .AHF..IERDTLR...TYLNQVYDIERLVGRVS........YGNV..NARDLIQLKH.SISEIPN 121 .SFV..SLIRMLF...ESCKGYPNSFINSLKYPisl10nsrVSIE..NLRDIIVFLD.EVLRINL 122 .EDA..ELRQTLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPN 123 .---..-----RG...LGLSEIQDLSDIVERAV........SGQLl.TVRELCTVRS.TLTAATS 124 .RIH..ELCEVEF...PTMPELSNLDKAL--VH........LSKQ..GILHLDEIFE.FVKIFRY 125 .RIH..ELCEVEF...PTIPELSNLDKAL--VH........LSKQ..GILHLDEIFE.FVKIFRY 126 .EDA..ELRQTLQe..DLLRRFPDLNRLAKKFQ........RQAA..NLQDCYRLYQ.GINQLPN 127 .EDA..EARQLLLdddHLLRSIPDIPKLCRRLT........RGSA..SLEDVVRIYQ.MAKALPK 128 .---..-------...-----------------........----..----------.----VAS 129 .---..-------...-----------------........----..----------.------- 130 .---..-------...-----------------........----..----------.------- 131 .EDA..ELRQTLQ...-----------------........----..----------.------- 132 .---..-------...-----------------........----..----------.------- 133 .RIFpgGAAAKIL...RELEGIEDVMRRNERLE........----..NIEEIIRRYE.S-ELNKR 134 .NVF..PN-GVSR...KILERLNELEDVFKRLK........--TL..ENLEERIREL.EIELNRK 135 .---..-------...-----------------........----..----------.------- 136 .---..-------...-----------------........----..----------.------- 137 .---..-------...-----------------........----..----------.------- 138 .---..-------...-----------------........----..----------.------- 139 .EVV..EIMDELQ...AAGGEEVDIDEVVNSVKa.......WADM..KLRDLIKDID.------- 140 .---..-------...-----------------........----..----------.------- 141 .---..-------...-----------------........----..----------.------- 142 .---..-------...-----------------........----..----------.------- 143 .---..-------...-----------------........----..----------.------- 144 .---..-------...-----------------........----..----------.------- 145 .---..-------...-----------------........----..----------.------- 146 .---..-------...-----------------........----..----------.------- 147 .---..-------...-----------------........----..----------.------- 148 .---..-------...-----------------........----..----------.------- 149 .---..-------...-----------------........----..----------.------- 150 .---..-------...-----------------........----..----------.------- 151 .---..-------...-----------------........----..----------.------- 370 380 390 | | | 1 LRALLGEE........VGLP........D......LSPLK..EEL.EAA...LVE........DP 2 LRALLGEE........VGLP........D......LSPLK..EEL.EAA...LVE........DP 3 LKGLLGEE........VGLP........D......LSGLL..EEL.RAA...LVE........DP 4 LKGLLGEE........VGLP........D......LSGLL..EEL.RAA...LVE........DP 5 LKGLLGEE........VGLP........D......LSGLL..EEL.RAA...LVE........DP 6 LEGLLGEE........VGLP........D......LSGLL..EEL.RAA...LVE........DP 7 LRAQLETV........DSAPvqa9ekmgE......FAELR..DLL.ERA...IID........TP 8 LRAQLETV........DSAPvqa9ekmgE......FAELR..DLL.ERA...IID........TP 9 LQTALSPL........EAPHlqa9gnirT......YPELA..ELL.RRA...IID........NP 10 LRAQLETV........DSAPvqa9ekmgE......FAELR..DLL.ERA...IID........TP 11 LRAIVQQK........TPPFlta9sqiaD......FSEQC..DLL.QRA...LIE........TP 12 LQNAMTEL........EAPHlqa9ttigT......YPELA..ELL.AKA...IID........NP 13 LQNAMTEL........EAPHlqa9ttigT......YPELA..ELL.AKA...IID........NP 14 VIQALEKY........EGRHqal17lrsD......FSKFQ..EMI.ETT...L--........DM 15 LHAQLETV........DSAPvqa9kkmgD......FAELR..DLL.ERA...IID........AP 16 VIQALEKY........EGRHqal17lrsD......FSKFQ..EMI.ETT...L--........DM 17 VIQALEKH........EGKHqkl17lrsD......FSKFQ..EMI.ETT...L--........DM 18 VIQALEKH........EGKHqkl17lrsD......FSKFQ..EMI.ETT...L--........DM 19 VSGLLEEV........AGGFtsk18pkgR......FPDLT..AEL.QRW...DTA........FD 20 LETVDSAP........VQRCvkkw....A......ISPSC..ATS.WNA...PLL........TR 21 VSGLLEEV........AGGFtsk18pkgR......FPDLT..AEL.QRW...DTA........FD 22 IIGIMEEV........ADGFksk18pegR......FPDLT..VEL.NRW...DTA........FD 23 IIGIMEEV........ADGFksk18pegR......FPDLT..VEL.NRW...DTA........FD 24 IIGIMEEV........ADGFksk18pegR......FPDLT..VEL.NRW...DTA........FD 25 IIGIMEEV........ADGFksk18pegR......FPDLT..VEL.NRW...DTA........FD 26 VIQALEKY........QGRHqal17lrsD......FSKFQ..EKI.ETT...L--........DM 27 VVQAIEKY........EGTHqml17lssD......FSKFQ..EMI.ETT...L--........DM 28 IRAILEGM........EQPTlay9aqldA......IPELE..SLI.SAA...IAP........EA 29 LAELAQEGhsp9kalqTVPP........E......LEELG..KYV.LAH...IVE........NP 30 IKQLVASL........AHDKake9kridP......CGDVL..ELL.EEA...LYE........NP 31 LAELAQEGhsp9kalqTVPP........E......LEELG..KYV.LAH...IVE........NP 32 IAHDLQSY........TLPEflt10issS......LKSLI..EAL.STD...LLQ........EL 33 IDLSANGS........SLLEtlkavfp.E......NLSTA..EQL.RQA...ILP........EP 34 IKQLVASL........AHDKake9kridP......CGDVL..ELL.EEA...LYE........NP 35 ELQALMPA........VNSHvqs11livE......LLSPV..EHY.LKV...LNG........PA 36 EFQAIIPA........VNSHiqs14eipE......LLSPV..EHY.LKI...LNE........QA 37 IKGLFSES........YGLNlph11ikp-lsg...DAELY..NLI.HMS...IRE........DA 38 ELQALMPA........VNSHvqs11livE......LLSPV..EHY.LKV...LNG........PA 39 LRELLNAS........DSPRlrv9aelgE......HDSTA..SLL.VKA...VAE........QP 40 ELQALMPA........VNSHvqs11livE......LLSPV..EHY.LKV...LNG........PA 41 EFQAIIPA........VNSHiqs14eipE......LLSPV..EHY.LKI...LNE........QA 42 IELSAECSsl......LG--tlkavfp.E......NLSTA..EQL.RQA...ILP........EP 43 LNEVLSTFgvf.....KKLA........F......PEGLV..DLL.RKA...IED........DP 44 IADNLQNC........ALPEfle10iapP......LCSLI..KTL.STE...LIQ........EL 45 IYEQLASA........TLPEffidkcsl-dtk...LASLI..ALL.SKS...LNG........DL 46 ISALLSGA........ELSAelt11iaaL......PGELL..ARL.DAT...LAE........EL 47 IYEQLASA........TLPEffidkcsl-dtk...LASLI..ALL.SKS...LNG........DL 48 LRKILSLL........DSEIfke9gsllN......LNKVA..DLI.DKT...LVD........DP 49 LNEVLSTFgvf.....KKLA........F......PEGLV..DLL.RKA...IED........DP 50 FRSLERES........PFPPdll10dtpV......LQELY..GLL.EQS...IKE........DC 51 ILKVLHELdns14pfkSFLK........D......LTGLK..QMV.EQV...V--........DF 52 ISSIIDHF........LGMF........D......QKEAE..NNN.KVD...MFKdi......DN 53 LRLLLLEL........KAPIfke9qnfeD......TKKII..NDI.EKT...LVE........DP 54 ISSIIDHF........LGMF........D......QKEAE..NNN.KVD...MFKdi......DN 55 VIQALEKH........EGKHqkl17lrsD......FSKFQ..EMI.ETT...L--........DM 56 AFDQLREE........FMEVaeg11iiqS......APNMK..EEL.EAW...TRA........FN 57 MAEACSSLrai10tsr----rll13slpN......ISSSI..KY-.FKD...AFD........WV 58 IKTAMQQY........TGEFasl19dqdH......LGKFI..DLV.ECS...V--........DL 59 IKTAMQQY........TGEFasl19dqdH......LGKFI..DLV.ECS...V--........DL 60 ILKVLHELdns14pfkSFLK........D......LTGLK..QMV.EQV...V--........DF 61 VKKLFDKH........NFDY........W......NFDKF..EED.SISkvyFLI........NS 62 MAEACSSLrai11srr----llhl....L......TPGII..NLL.HIH...ILIlan32afdWV 63 QIQRLGIKqds10mqs----atvrst..L......LRKLI..SVI.SSP...VVVdna14keaAV 64 --------........----........-......-----..---.---...QVV........DF 65 IKGILQQY........NGQFstl.....I......RSKFL..EPL.EEW...MAKnrf14taiDL 66 LQDSLKNNdlkgdvskYISS........F......PEGLV..EAV.KSW...TNA........FE 67 HFKMHQSY........LSEHfks32qlpH......FLTMI..NVS.AVM...EKN........SD 68 LQDSLKNNdlkgdvskYISS........F......PEGLV..EAV.KSW...TNA........FE 69 FIGTLEGV........MDEAyrd18lsdS......LVKLQ..EMV.ETT...V--........DL 70 IRKYLLNN........TSLMkat16slnF......EKNLI..DDI.LKF...LNEeel30esnKD 71 IHSLLSPLess10lllLNMH........P......HDELK..QLI.NNA...VDEnal43sefDI 72 HFKMHQSY........LSEHfks32qlpH......FLTMI..NVS.AVM...EKN........SD 73 IRKYLLNN........TSLMkat16slnF......EKNLI..DDI.LKF...LNEeel30esnKD 74 IVTVLDSL........TSEHkdl17hckN......LEKLI..ELV.ETT...I--........DL 75 LRKEYIKV........QKEG........E......GCELL..DEL.LGN...EQEmee16mfdRS 76 IVQVFTSFled22aplSHH-v.......E......PLSKF..EEM.VET...TVD........LD 77 IVQVFTSFled22aplSHH-v.......E......PLSKF..EEM.VET...TVD........LD 78 --------........----........-......-----..---.---...--K........II 79 --------........----........-......-----..---.---...--K........II 80 PGSSSPGL........RVLNf.......L......DEKFI..AVM.EAI...LLAgkq55keaAV 81 PVSSSPGL........RVLNf.......L......DEKFI..AVM.EAI...LLAgkq55keaAV 82 --------........----........-......-----..---.---...---........-- 83 LRDACRSL........PQSIqlf11efsD......DLHHI..ASL.IGK...VVD........FE 84 LRDACRSL........PQSIqlf11efsD......DLHHI..ASL.IGK...VVD........FE 85 LRDACRSL........PQSIqlf11efsD......DLHHI..ASL.IGK...VVD........FE 86 INRLLKSE........ITEI........Lk.....KVERF..QVL.CDE...FFD........FD 87 ELQALMPA........VNSHvqs11livE......LLSPV..EHY.LKV...LNG........PA 88 IHSLLSPLess10lllLNMH........P......HDELK..QLI.NNA...VDEnal43sefDI 89 ILNIIRQT........PISKefp9sdllR......EVSEI..AVI.AGS...IIN........FA 90 ILNIIRQT........PISKefp9sdllR......EVSEI..AVI.AGS...IIN........FA 91 LRDACRSL........PQSIqlf11efsD......DLHHI..ASL.IGK...VVD........FE 92 LRDACRSL........PQSIqlf11efsD......DLHHI..ASL.IGK...VVD........FE 93 LKIAMKNC........NTPLlra18ileK......IKTVI..NDD.ARY...MKG........CL 94 LKIAMKNC........NTPLlra18ileK......IKTVI..NDD.ARY...MKG........CL 95 ILNIIRQT........PISKefp9sdllR......EVSEI..AVI.AGS...IIN........FA 96 MFHACSSI........STLIcse16gkg-......LSNIS..SIL.DRFrd.AFD........WS 97 LQNAMTEL........EAPHlar9aitgT......YPELA..SLL.ERA...IID........NP 98 LKDALNDQ........LIQSrli20iekL......INSCI..NED.CVW...ASS........AI 99 LKDALNDQ........LIQSrli20iekL......INSCI..NED.CVW...ASS........AI 100 IRTLLHSA........KMKSnil21mniL......VEKVD..DSL.LDG...KKN........SL 101 IRKSIQNV........SSHLlvq18llaI......INEYI..RND.CQW...ANN........ST 102 LISKLTNN........IQLPplvgp...Q......LKSLI..KEI.ERI...FQV........DS 103 IFQLVSSL........KLGSdea13nkvD......ISALK..ECL.RKVet.VID........FD 104 IFQLVSSL........KLGSdea13nkvD......ISALK..ECL.RKVet.VID........FD 105 LISKLTNN........IQLPplvgp...Q......LKSLI..KEI.ERI...FQV........DS 106 IIGIMEEV........ADGFksk18pegR......FPDLT..VEL.NRW...DTA........FD 107 LPTMFHQC........KTTLlkr12sggS......FPDLS..KEL.QYF...ATA........FD 108 MKHFITQMaedg....VDIP........L......IHQHA..EQL.ITLsd.LER........DI 109 IRRVLSSH........VQRLe.......P......LRKVY..KKL.YTFsp.LEN........LI 110 --------........----........-......-----..---.---...---........-- 111 LKKEFEKR........EYSR........L......KETFS..RLSsFRE...FVE........EV 112 --------........----........-......-----..---.---...---........-- 113 VIQALEKH........EGKHqkl17lrsD......FSKFQ..EMI.ETT...L--........DM 114 LRRVIEER........DDLE........I......LQTLV..AEV.RTLpe.LEQ........AI 115 VKRAIETN........SRGP........LrdvatgLGDHS..ELV.RRV...L--........-- 116 LQNAFKTF........THLK........F......HERLN..AIV.LPP...FFN........DL 117 LQNAFKPF........THLK........F......HERLN..AII.LPP...FFN........DL 118 --------........----........-......-----..---.---...---........-- 119 FKTFYNQLveedegv.KYPI........L......DDKMN..QLP.VLT...DLF........QQ 120 IKALLNSMnqntlvqvNQLE........P......LDDLL..DIL.EQS...LVE........EP 121 FLHKNSDI........KHLNvqi12lnpE......LKNLL..NEL.KEH...IDV........DA 122 VIQALEKH........EGKHqkl17lrsD......FSKFQ..EMI.ETT...L--........DM 123 TFQKLRKAaisdnrv.TPLV........D......ILQGC..DFK.DTL...QQK........IS 124 FEKLKKIK........LGTN........L......GSWLQ..KIE.FVS...GAL........EL 125 FEKLKKIK........LGTN........L......DSWLQ..KIE.FVS...GAL........EL 126 VIQALEK-........----........-......-----..---.---...---........-- 127 IVTVLDSL........TSEHkdl17hckN......LEKLI..ELV.ETT...I--........DL 128 LLRFFENL........QLDLkaa15rfmP......LSELIvhPVI.NRS...FVK........LV 129 --------........----........-......-----..---.---...---........-- 130 --------........----........-......-----..---.---...---........-- 131 --------........----........-......-----..---.---...---........-- 132 --------........----........-......-----..---.---...---........-- 133 IEEKLERF........KLTL........S......GKELV..EFL.RSL...RYG........DV 134 IEEKLEDF........KLTL........S......GRELV..EFI.RAL...RSG........DI 135 --------........----........-......-----..---.---...---........-- 136 --------........----........-......-----..---.---...---........-- 137 --------........----........-......-----..---.---...---........-- 138 --------........----........-......-----..---.---...---........-- 139 ---LSGDE........VLTL........L......NQGMT..AKL.ERI...---........-- 140 --------........----........-......-----..---.---...---........-- 141 --------........----........-......-----..---.---...---........-- 142 --------........----........-......-----..---.---...---........-- 143 --------........----........-......-----..---.---...---........-- 144 --------........----........-......-----..---.---...---........-- 145 --------........----........-......-----..---.---...---........-- 146 --------........----........-......-----..---.---...---........-- 147 --------........----........-......-----..---.---...---........-- 148 --------........----........-......-----..---.---...---........-- 149 --------........----........-......-----..---.---...---........-- 150 --------........----........-......-----..---.---...---........-- 151 --------........----........-......-----..---.---...---........-- 400 410 420 430 4 | | | | 1 PLKVSEGGLIRE..GYDPDLDALR.AAHREGVAYFLELEERERERT.......GIP.......TL 2 PLKVSEGGLIRE..GYDPDLDALR.AAHREGVAYFLELEERERERT.......GIP.......TL 3 PLKVSEGGLIRE..GYDPDLDALR.RAHAEGVAYFLDLEAREKERT.......GIP.......TL 4 PLKVSEGGLIRE..GYDPDLDALR.RAHAEGVAYFLDLEAREKERT.......GIP.......TL 5 PLKVSEGGLIRE..GYDPDLDALR.RAHAEGVAYFLDLEAREKERT.......GIP.......TL 6 PLKVSEGGVIRE..GYDPDLDALR.RAHADPVAYFLDLEVREKEST.......GIP.......TL 7 PVLVRDGGVIAS..GYNEELDEWR.ALADGATDYLERLEVRERERT.......GLD.......TL 8 PVLVRDGGVIAS..GYNEELDEWR.ALADGATDYLERLEVRERERT.......GLD.......TL 9 PAVIRDGGVLKQ..GYDAELDELL.SLSENAGQFLMDLEAREKART.......GLP.......NL 10 PVLVRDGGVIAS..GYNEELDEWR.ALADGATDYLERLEVRERERT.......GLD.......TL 11 PLLIRDGGVIAE..GYNAELDEWR.MLSDGATQYLENLEKREREST.......GID.......TL 12 PAVIRDGGVIKT..GYDAELDELQ.ALSENAGQFLMDLEAREKART.......GLP.......NL 13 PAVIRDGGVIKT..GYDAELDELQ.ALSENAGQFLMDLEAREKART.......GLP.......NL 14 DQVENHEFLVKP..SFDPNLSELR.EVMDGLEKKMQSTLINAARGL.......GLDpgk....QI 15 PVLVRDGAVIAP..GYHEELDEWR.ALADGATDYLDRLEIRERERT.......GLD.......TL 16 DQVENHEFLVKP..SFDPNLSELR.EVMDGLEKKMQSTLINAARGL.......GLDpgk....QI 17 DQVENHEFLVKP..SFDPNLSELR.EIMNDLEKKMQSTLISAARDL.......GLDpgk....QI 18 DQVENHEFLVKP..SFDPNLSELR.EIMNDLEKKMQSTLISAARDL.......GLDpgk....QI 19 HEKARKTGLITPkaGFDSDYDQAL.ADIRENEQSLLEYLDKQRSRL.......GCK.......SI 20 RRYWSRRRVIAP..GYHEELDEWR.ALADGATDYLDRLEIRERERT.......GLD.......TL 21 HEKARKTGLITPkaGFDSDYDQAL.ADIRENEQSLLEYLDKQRSRL.......GCK.......SI 22 HEKARKTGLITPkaGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI.......GCR.......TI 23 HEKARKTGLITPkaGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI.......GCR.......TI 24 HEKARKTGLITPkaGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI.......GCR.......TI 25 HEKARKTGLITPkaGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI.......GCR.......TI 26 DQVENHEFLVKP..SFDPNLSELR.EVMDGLEKKMQSTLISAARGL.......GLDpgk....QI 27 DQVENHEFLVKA..SFDPNLTELR.EKMDELEKNMQGALGGAAREL.......GLDagk....SI 28 PHVITDGGIIRT..GFDETLDKYR.CVLREGTSWIAEIEAKERENS.......GIS.......TL 29 PLHIREGNLIRS..GVNPTLDEMR.QSLEDDNQWLANLEVTEREKT.......GIA.......NL 30 PLSVKEGNLIKD..GYNQKLDEYR.DASRNGKDWIARLEQQEREYT.......GIR.......SL 31 PLHIREGNLIRS..GVNPTLDEMR.QSLEDDNQWLANLEVTEREKT.......GIA.......NL 32 PLKVSEGNIFAD..HYHQDLLRLR.NIKTNSKSWILEYQERIRQET.......GIK.......KL 33 SVWLKDGNVINH..GFHPELDELR.RIQNHGDEFLLDLEAKERERT.......GLS.......TL 34 PLSVKEGNLIKD..GYNQKLDEYR.DASRNGKDWIARLEQQEREYT.......GIR.......SL 35 AKVGDKTELFKD..LSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL.......KLP.......SL 36 AKVGDKTELFKD..LSDFPLIKKRkDEIQGVIDEIRMHLQEIRKIL.......KNP.......SA 37 PNNLNDGGIIKY..EFHPKIAQLN.DLINNKKLHVEKLKDQYRKET.......RIE.......SL 38 AKVGDKTELFKD..LSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL.......KLP.......SL 39 PLKLTDGGVIAS..EYDVELDELR.KLSNNADQFLIDLETRERESS.......GIS.......TL 40 AKVGDKTELFKD..LSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL.......KLP.......SL 41 AKVGDKTELFKD..LSDFPLIKKRkDEIQGVIDEIRMHLQEIRKIL.......KNP.......SA 42 SVWLKDGNVINH..GFHPELDELR.RIQNHGDEFLLDLEAKERERT.......GLS.......TL 43 VGSPGEGKVIKR..GFSSELDEYR.DLLEHAEERLKEFEEKERERT.......GIQ.......KL 44 PLKVSEGNIFAN..HYHPDLLRLR.NIKENSKSWILEYQERIRNET.......GIK.......KL 45 PLRVSDGNIFVD..EFHNDLKRLR.HNQEHSQEWIWEYQERIRKET.......GIK.......KL 46 PLLKRDGGFVRE..GASAELDEMR.ALRDQSRRVIAGLQLQYCEET.......GIK.......SL 47 PLRVSDGNIFVD..EFHNDLKRLR.HNQEHSQEWIWEYQERIRKET.......GIK.......KL 48 PLHVKEGGLIKP..GVNAYLDELR.FIRENAEKLLKEYEKKLKKET.......GIQ.......SL 49 VGSPGEGKVIKR..GFSSELDEYR.DLLEHAEERLKEFEEKERERT.......GIQ.......KL 50 PVTLSDGNLIKR..GFSASLDELH.RVRDNANEILKQYLAEERERT.......GIG.......TL 51 EAIERGEYLVKA..SFDSRLMELQ.QMMTELYSKMEELQFKCSQEL.......NLDgkn....QV 52 FDLSEEPNDVDY..ELAQEIRELK.MSILMVRTEMDFHLQELRDYL.......EYP.......NL 53 PLHVKEGGLIRE..GVNAYLDELR.FIRDNAETYLREYEKKLRQET.......GIQ.......SL 54 FDLSEEPNDVDY..ELAQEIRELK.MSILMVRTEMDFHLQELRDYL.......EYP.......NL 55 DQVENHEFLVKP..SFDPNLSELR.EIMNDLEKKMQSTLISAARDL.......GLDpgk....QI 56 WQKASEEGVFEPeiGFEAEYDTSQ.KYQSELKNELYALLEQYKKQL.......RCS.......SL 57 EAHNSGRVIPHE..GADEEYDCAC.KTVEEFESSLKKHLKEQRKLL.......GDA.......SI 58 DQLENGEYMISS..SYDTKLASLK.DQKELLEQQIHELHKKTAIEL.......DLQvdk....AL 59 DQLENGEYMISS..NYDTKLASLK.DQKELLEQQIHELHKKTAIEL.......DLQvdk....AL 60 EAIERGEYLVKA..SFDSRLMELQ.QMMTELYSKMEELQFKCSQEL.......NLDgkn....QV 61 AISSAPDELIKR..GYDLKLDNLK.DLKINANKYIDQYLESERLLS.......KIN.......NL 62 EAHNSGRVIPHE..GADEEYDCAC.KTVEEFESSLKKHLKEQRKLL.......GDA.......SI 63 RGDLLDILITSS..DQFPELAEAR.QAVLVIREKLDSSIASFRKKL.......AIR.......NL 64 EAIERGEYLVKA..SFDSRLMELQ.QMMTELYSKMEELQFKCSQEL.......NLDgkn....QV 65 AQLENGEYRISP..LYSSDLGVLK.DELSVVENHINNLHVDTASDL.......DLSvd.....KQ 66 RQKAINENIIVPqrGFDIEFDKSM.DRIQELEDELMEILMTYRKQF.......KCS.......NI 67 KQVMDFFNLNNY..DCSEGIIKIQ.RESESVRSQLKEELAEIRKYL.......KRP.......YL 68 RQKAINENIIVPqrGFDIEFDKSM.DRIQELEDELMEILMTYRKQF.......KCS.......NI 69 DALDNHEFIIKP..EFDDSLRIIR.KKLDRLRTDMDNEFAEAAEDL.......GQErek....KI 70 EIFELRDFIVNP..SFNTKLRKLH.DTYQGVWQKKTEYNALLKGFFvgdl...GAK.......TF 71 RQSFKENWVVKS..NFNNNLRKLH.EKLQSLFASYDKLQEDLSKRL.......GKK.......-A 72 KQVMDFFNLNNY..DCSEGIIKIQ.RESESVRSQLKEELAEIRKYL.......KRP.......YL 73 EIFELRDFIVNP..SFNTKLRKLH.DTYQGVWQKKTEYNALLKGFFvgdl...GAK.......TF 74 EALDSHQYIIRA..EFDEELLDLR.QRLDELQHSIFEEHKRVGSDL.......HQDtek....KL 75 TAMKDGKIVPNA..GCDEEYDEAL.NRVKEALNELNDYKDSVAKKY.......SCS.......-I 76 AYEENNEFMIKV..EFNEELGKIR.SKLDTLRDEIHSIHLDSAEDL.......GFDpdk....KL 77 AYEENNEFMIKV..EFNEELGKIR.SKLDTLRDEIHSIHLDSAEDL.......GFDpdk....KL 78 KKRIKTFIMLIN..GLRNGIDLLN.DLQRADHGILA----------.......---.......LY 79 KKRIKTFIMLIN..GLRNGIDLLN.DLQRADHGILA----------.......---.......LY 80 RGDLLDILITSS..DQFPELAEAR.QAVLVIREKLDSSIASFRKKL.......AIR.......NL 81 RGDLLDILITSS..DQFPELAEAR.QAVLVIREKLDSSIASFRKKL.......AIR.......NL 82 KQRVKAFGQIVK..GFRSGIDLLL.ALQKE--SNMMSLLYKLCKLP.......ILV.......GK 83 GSLAENRFTVLP..NIDPEIDEKK.RRLMGLPSFLTEVARKELENLds.....RIP.......SC 84 GSLAENRFTVLP..NIDPEIDEKK.RRLMGLPSFLTEVARKELENLds.....RIP.......SC 85 GSLAENRFTVLP..NIDPEIDEKK.RRLMGLPSFLTEVARKELENLds.....RIP.......SC 86 YEKENKEIRVRV..DFVPEIQEIS.EKLEQMERVAEKLRKKYSAKF.......ECD.......NL 87 AKVGDKTELFKD..LSDFPLIKKRkNEIQEVIHSIQMRLQEFRKIL.......KLP.......SL 88 RQSFKENWVVKS..NFNNNLRKLH.EKLQSLFASYDKLQEDLSKRL.......GKK.......-A 89 ESKIQGRVTVMN..GIDEELDEIR.DTYENMPMVLTAIAKQEEARL.......GLPpys....NV 90 ESKIQGRVTVMN..GIDEELDEIR.DTYENMPMVLTAIAKQEEARL.......GLPpys....NV 91 ESLAENRFTVLP..NIDPDIDAKK.RRLIGLPSFLTEVAQKELENLds.....RIP.......SC 92 ESLAENRFTVLP..NIDPDIDAKK.RRLIGLPSFLTEVAQKELENLds.....RIP.......SC 93 NMRTQKCYAVRS..NINEFLDIAR.RTYTEIVDDIAGMISQLGEKY.......SLP.......-L 94 NMRTQKCYAVRS..NINEFLDIAR.RTYTEIVDDIAGMISQLGEKY.......SLP.......-L 95 ESKIQGRVTVMN..GIDEELDEIR.DTYENMPMVLTAIAKQEEARL.......GLPpys....NV 96 DADRNGRFIPYE..GCDPEFDATC.NAIEEIKSSLKEYLKEQRKLL.......RPA.......SV 97 PAVIRDGGVLKA..GYDNELDEML.AISENAGQFLIDLEAREKART.......GLA.......NL 98 QLLNQRSYAVKS..DSNGLLDVSR.QIYKEVKEEFFREVEDLTAKN.......KI-.......NL 99 QLLNQRSYAVKS..DSNGLLDVSR.QIYKEVKEEFFREVEDLTAKN.......KI-.......NL 100 HLQNTKCYAIRH..FVAVQLDLAR.QTYEEIIRNVEETGAREIAEYfh.....GNS.......SV 101 ELANQRANAVKS..GVNGLLDVSR.RIRETLLEEVSELVAKLSEEL.......EIF.......-M 102 LLGDFKDVIQPI..GNLPNLFEQR.QTLRAQLTEWAEQISNIV-FQ.......DTT.......SI 103 TSRDTKTLTINT..GVDNRLDECR.NIYNHLEGILLDVARETQIFLlntmpqeDCKttkslekLV 104 TSRDTKTLTINT..GVDNRLDECR.NIYNHLEGILLDVARETQIFLlntmpqeDCKttkslekLV 105 LLGDFKDVIQPI..GNLPNLFEQR.QTLRAQLTEWAEQISNIV-FQ.......DTT.......SI 106 HEKARKTGLITPkaGFDSDYDQAL.ADIRENEQSLLEYLEKQRNRI.......GCR.......TI 107 HDAAAKTGVIAPqaGMDAEYDAAM.DSIGEVEKRLKTYLVEQERHF.......GCR.......-I 108 NSCIDDHGEVLD..HASETLRGIR.TQLRTLESRVRDRLESMLRSS.......SASkml....SD 109 IGSIDPRGFVKD..EASEELLRVR.KSIRAVEEEIKKRLDNLINRP.......DSAkfl....SD 110 ------------..----------.---------------------.......---.......-- 111 NRCIEQDGEISD..RASPRLREIR.TEKKRLSSEIKRKADDFVRTHs......QIL.......QE 112 ------------..----------.---------------------.......---.......-- 113 DQVENHEFLVKP..SFDPNLSELR.EIMNDLEKKMQSTLISAARDL.......GLDpgk....QI 114 HHCLGEDGKVAE..RASPKLGEIR.QKLKAVREQIQQKLQKIIQRQ.......SNAl......QE 115 -QSLDREGNVRD..DASPRLRDLR.KRIEPLRGRIREKLTQTLEKWs......DVL.......QE 116 IALFDDEGKIKQ..GANATLDALN.ESLNRLKKESVKIIHHYARSK.......ELApy.....LV 117 ILLLDDEGQIKQ..GANATLDALN.ESLNRLKKESTKIIHHYAHSK.......ELApy.....LV 118 ------------..----------.---------------------.......---.......-- 119 INETCDTYDLYD..NASYELQGIR.SKISSTNQRIRQNLDRIVKSQa......-NQkkl....SD 120 PISVKDGGLFKV..GFNTQLDE--.---------------------.......---.......-- 121 LELKSGVVKEYD..SIEFEIKNLN.RRVENQIKKIISLNAEYL---.......---.......TS 122 DQVENHEFLVKP..SFDPNLSELK.---------------------.......---.......-- 123 FCIDCNMTMILD..RASEDLEIIR.SERRRNMENLDSLLKKISTKIfla....---ggi....NK 124 CLNFDEKGELKE..SLDERLVNLN.AALRLKNESIIAEFKKFCYTK.......ALMpy.....LI 125 CLNFDEKGELKE..SLDERLVNLN.AALRLKNESIIAEFKKFCYTK.......ALMpy.....LI 126 ------------..----------.---------------------.......---.......-- 127 EALDSHQYIIRA..EFDEELLDLR.QRLDELQHSIFEEHKRVGSDL.......HQDtek....KL 128 EQVIDPDGTIKD..SASSALRQSR.ERVQTLERKLQQLLDAIIRSQ.......KDDesvmi..KF 129 ------------..----------.---------------------.......---.......-- 130 ------------..----------.---------------------.......---.......-- 131 ------------..----------.---------------------.......---.......-- 132 ------------..----------.---------------------.......---.......-- 133 EAILSKFSSLND..DI--------.------IEEIRKAEEKLSQEL.......GVA.......-- 134 EVVLSKFSALND..----------.----EILDEIKKTEEELSKEL.......GID.......-- 135 ------------..----------.---------------------.......---.......-- 136 ------------..----------.---------------------.......---.......-- 137 ------------..----------.---------------------.......---.......-- 138 ------------..----------.---------------------.......---.......-- 139 ------------..----------.---------FDDVLSEARSMI.......KKR.......SG 140 ------------..----------.---------------------.......---.......-- 141 ------------..----------.---------------------.......---.......-- 142 ------------..----------.---------------------.......---.......-- 143 ------------..----------.---------------------.......---.......-- 144 ------------..----------.---------------------.......---.......-- 145 ------------..----------.---------------------.......---.......-- 146 ------------..----------.---------------------.......---.......-- 147 ------------..----------.---------------------.......---.......-- 148 ------------..----------.---------------------.......---.......-- 149 ------------..----------.---------------------.......---.......-- 150 ------------..----------.---------------------.......---.......-- 151 ------------..----------.---------------------.......---.......-- 40 450 460 470 48 | | | | 1 KVGYNAVFGYYLEVTR.....PYY....ER....VPKE........YRPVQTLKD...RQRYTLP 2 KVGYNAVFGYYLEVTR.....PYY....ER....VPKE........YRPVQTLKD...RQRYTLP 3 KVGYNAVFGYYLEVTR.....PYY....EK....VPQE........YRPVQTLKD...RQRYTLP 4 KVGYNAVFGYYLEVTR.....PYY....EK....VPQE........YRPVQTLKD...RQRYTLP 5 KVGYNAVFGYYLEVTR.....PYY....EK....VPQE........YRPVQTLKD...RQRYTLP 6 KVGYNAVFGYYLEVTR.....PYY....EK....VPQE........YRPVQTLKD...RQRYTLP 7 KVGFNAVHGYYIQISR.....GQS....HL....APIN........YMRRQTLKN...AERYIIP 8 KVGFNAVHGYYIQISR.....GQS....HL....APIN........YMRRQTLKN...AERYIIP 9 KVGYNRIHGYYIELPR.....VQA....EQ....APAD........YIRRQTLKG...AERFITP 10 KVGFNAVHGYYIQISR.....GQS....HL....APIN........YMRRQTLKN...AERYIIP 11 KIGFNAVHGYYIQISQ.....GQA....HK....APIH........YVRRQTLKN...AERYIIP 12 KVGYNRIHGYFIELPR.....VQA....EQ....APAD........YIRRQTLKG...AERFITP 13 KVGYNRIHGYFIELPR.....VQA....EQ....APAD........YIRRQTLKG...AERFITP 14 KLDSSAQFGYYFRVTC.....KEE....KV....LRNNkn......FSTVDIQKN...GVKFTNS 15 KVGYNAVHGYYIQISR.....GQS....HL....APIN........YVRRQTLKN...AERYIIP 16 KLDSSAQFGYYFRVTC.....KEE....KV....LRNNkn......FSTVDIQKN...GVKFTNS 17 KLDSSAQFGYYFRVTC.....KEE....KV....LRNNkn......FSTVDIQKN...GVKFTNS 18 KLDSSAQFGYYFRVTC.....KEE....KV....LRNNkn......FSTVDIQKN...GVKFTNS 19 VYWGIGRNRYQLEIPE.....NFA....TRn...LPEE........YELKSTKKG...CKRYWTK 20 KVGYNAVHGYYIQISR.....GQS....HL....APIN........YVRRQTLKN...AERYIIP 21 VYWGIGRNRYQLEIPE.....NFA....TRn...LPEE........YELKSTKKG...CKRYWTK 22 VYWGIGRNRYQLEIPE.....NFT....TRn...LPEE........YELKSTKKG...CKRYWTK 23 VYWGIGRNRYQLEIPE.....NFT....TRn...LPEE........YELKSTKKG...CKRYWTK 24 VYWGIGRNRYQLEIPE.....NFT....TRn...LPEE........YELKSTKKG...CKRYWTK 25 VYWGIGRNRYQLEIPE.....NFT....TRn...LPEE........YELKSTKKG...CKRYWTK 26 KLDSSAQFGYYFRVTC.....KEE....KV....LRNNkn......FSTVDIQKN...GVKFTNS 27 KLESNSQIGHYFRVTC.....KEE....KA....LRNNkk......FTTIDIQKN...GVRFTNS 28 KIDYNKKDGYYFHVTN.....SQL....GN....VPAH........FFRKATLKN...SERFGTE 29 KVGYNKAFGYYLSLPR.....SKS....EQ....APDN........YIRKQTLVN...EERYITP 30 KVGFNKVFGYYIEVTK.....ANL....HL....LEEGr.......YERNETLTN...AERYITP 31 KVGYNKAFGYYLSLPR.....SKS....EQ....APDN........YIRKQTLVN...EERYITP 32 KVCYAQALGYYIEVAS.....SFA....PQ....LPKE........FIRRQSRLH...AERFTTQ 33 KVEFNRVHGFYIELSK.....TQA....EQ....APAD........YQRRQTLKN...AERFITP 34 KVGFNKVFGYYIEVTK.....ANL....HL....LEEGr.......YERNETLTN...AERYITP 35 QYVTVSGQEFMIEIKN.....SAV....SC....IPAD........WVKVGSTKA...VSRFHPP 36 QYVTVSGQEFMIEIKN.....SAV....SC....IPTD........WVKVGSTKA...VSRFHSP 37 KISHNNVLGFFIDITP.....KNV....NKi...LDPK........FIHRQTTIN...SVRYTTY 38 QYVTVSGQEFMIEIKN.....SAV....SC....IPAD........WVKVGSTKA...VSRFHPP 39 KVGYNRVHGYYIEISK.....GQA....DK....APVH........YTRRQTLTN...AERYITE 40 QYVTVSGQEFMIEIKN.....SAV....SC....IPAD........WVKVGSTKA...VSRFHPP 41 QYVTVSGQEFMIEIKN.....SAV....SC....IPTD........WVKVGSTKA...VSRFHSP 42 KVEFNRVHGFYIELSK.....TQA....EQ....APAD........YQRRQTLKN...AERFITP 43 RVGYNQVFGYYIEVTK.....ANL....DK....IPDD........YERKQTLVN...SERFITP 44 KVCYAQALGYYIEVAS.....NLA....PQ....LPKE........FIRRQSRLH...AERFTTQ 45 KICFAQALGYYIEVSS.....EFA....PQ....LPKD........FIRRQSRLH...AERFTTI 46 KIKHNNVLGYFIEVTA.....GNA....GS....MTDTdagrar..FIHRQTMAN...AMRFTTT 47 KICFAQALGYYIEVSS.....EFA....PQ....LPKD........FIRRQSRLH...AERFTTI 48 KIGYNKVMGYYIEVTK.....ANV....KY....VPEH........FRRRQTLSN...AERYTTE 49 RVGYNQVFGYYIEVTK.....ANL....DK....IPDD........YERKQTLVN...SERFITP 50 KMKYNRMLGHFLEVSK.....GHL....SA....VPAH........FIRRRSLSN...ADRFTTE 51 KLESVAKLGHHFRITV.....KDD....SV....LRKNkn......YRIVDVIKG...GVRFTSD 52 EFSIWGNVKFCIEVSK.....GC-....KK....IPPD........WIKLSSTRS...LFRFHTP 53 KIGYNKVMGYYIEVTK.....PNL....KY....VPSY........FRRRQTLSN...SERFTTE 54 EFSIWGNVKFCIEVSK.....GC-....KK....IPPD........WIKLSSTRS...LFRFHTP 55 KLDSSAQFGYYFRVTC.....KEE....KV....LRNNkn......FSTVDIQKN...GVKFTNS 56 NFKNIGKEVYQVEVPS.....DV-....-K....VPVN........WCKMSGTKK...TNRYYND 57 NYVTVGKDEYLLEVPE.....SLS....GS....VPHD........YELCSSKKG...VSRYWTP 58 KLDKAAQFGHVFRITK.....KEE....PK....IRKKlttq....FIVLETRKD...GVKFTNT 59 KLDKAAQFGHVFRITK.....KEE....PK....IRKKlttq....FIVLETRKD...GVKFTNT 60 KLESVAKLGHHFRITV.....KDD....SV....LRKNkn......YRIVDVIKG...GVRFTSD 61 KIRKTNNRGLFFEVTK.....SNY....AQ....VPPH........FMESQALNS...SKRYKTE 62 NYVTVGKDEYLLEVPE.....SLS....GS....VPHD........YELCSSKKG...VSRYWTP 63 EFLQVSGITHLIELPV.....D--....SK....VPMN........WVKVNSTKK...TIRYHPP 64 KLESVAKLGHHFRITV.....KDD....SV....LRKNkn......YRIVDVIKG...GVRFTSD 65 LKLEKGSLGHVFRMSK.....KEE....QK....VRKKltgs....YLIIETRKD...GVKFTNS 66 QYKDSGKEIYTIEIPI.....SAT....KN....VPSN........WVQMAANKT...YKRYYSD 67 NFR--DEVDYLIEVKN.....SQI....KD....LPDD........WIKVNNTKM...VSRFTTP 68 QYKDSGKEIYTIEIPI.....SAT....KN....VPSN........WVQMAANKT...YKRYYSD 69 FLENHKVHGWCMRLTR.....TEA....GC....IRNNsr......YLECSTQKN...GVYFTTK 70 TLKERQNGEYALHVTG.....TAS....SL....KKIDeli13gscFHILQKSSQ...TRWLSHK 71 TLRKSPAKLYYVHLKL.....SGN....ET....IERFikkftq..AVLFQSTKS...TASFQLP 72 NFR--DEVDYLIEVKN.....SQI....KD....LPDD........WIKVNNTKM...VSRFTTP 73 TLKERQNGEYALHVTG.....TAS....SL....KKIDeli13gscFHILQKSSQ...TRWLSHK 74 HLEQHHLYGWCLRLTR.....TEA....GC....LRGRssh.....YTELSTQKN...GVYFTTK 75 KFVDSGKVKYLLEMPE.....N--....TK....VSSS........FELKSRRKG...FIRYSTP 76 KLENHHLHGWCMRLTR.....NDA....KE....LRKHkk......YIELSTVKA...GIFFSTK 77 KLENHHLHGWCMRLTR.....NDA....KE....LRKHkk......YIELSTVKA...GIFFSTK 78 KIVDIPSLSYLPELIH.....KFE....ER....MQNE........FPCGQV---...------- 79 KIVDIPSLSYLPELIH.....KFE....ER....MQNE........FPCGQV---...------- 80 EFLQVSGITHLIELPV.....D--....SK....VPMN........WVKVNSTKK...TIRYHPP 81 EFLQVSGITHLIELPV.....D--....SK....VPMN........WVKVNSTKK...TIRYHPP 82 SGLELFLSQFEAAIDS.....DFP....NY....QNQ-........---------...------- 83 SVIYIPLIGFLLSIPRlpsmvEAS....DF....EING........LDFMFLSEE...KLHYRSA 84 SVIYIPLIGFLLSIPRlpsmvEAS....DF....EING........LDFMFLSEE...KLHYRSA 85 SVIYIPLIGFLLSIPRlpsmvEAS....DF....EING........LDFMFLSEE...KLHYRSA 86 KLDKNSQYGFYFRVTL.....KEE....KS....IRKKdv......HILETTKGS...GVKFSVG 87 QYVTVSGQEFMIEIKN.....SAV....SC....IPAD........WVKVGSTKA...VSRFHPP 88 TLRKSPAKLYYVHLKL.....SGN....ET....IERFikkftq..AVLFQSTKS...TASFQLP 89 ACVYIPLVGFVLSVPR.....DYG....VE....SQPD........MTLLYSTHE...DLRVRNA 90 ACVYIPLVGFVLSVPR.....DYG....VE....SQPD........MTLLYSTHE...DLRVRNA 91 SVIYIPLIGFLLSIPRlpfmvEAS....DF....EIEG........LDFMFLSED...KLHYRSA 92 SVIYIPLIGFLLSIPRlpfmvEAS....DF....EIEG........LDFMFLSED...KLHYRSA 93 RTSFSSARGFFIQMTT.....DCIalpsDQ....LPSE........FIKISKVKN...SYSFTSA 94 RTSLSSVRGFFIQMTT.....DCIalpsDQ....LPSE........FIKISKVKN...SYSFTSA 95 ACVYIPLVGFVLSVPR.....DYG....VE....SQPD........MTLLYSTHE...DLRVRNA 96 NYVNVGKDMYLIEVPE.....SLG....GS....VPRN........YELQSTKKG...FYRYWTP 97 KVGYNRVHGYFIELPT.....KQA....EQ....APGD........YIRRQTLKG...AERFITP 98 DHNYDSARGFYLRIKR.....QEF....TDdvatLPDV........FISRTIKKN...YIECTTL 99 DHNYDSARGFYLRIKR.....QEF....TDdvatLPDV........FISRTIKKN...YIECTTL 100 RLSFSQSRGFHYTFVT.....RQA....ESvt..IPRY........FLDVFRNRT...TVTFNSR 101 EYRFEISRGFFIKIKG.....NNT....DIns..LPEV........LINRVKKRK...TIECTTI 102 KAEYFNKEGYAFSISS.....KKL....TK....LEHYmmn10nnsIIVLGKRGS...HHIITSP 103 NAVYIPQLGYLVTISV.....LME....PL....LDGIpnlq....WEEIFRSSE...NIYFKNG 104 NAVYIPQLGYLVTISV.....LME....PL....LDGIpnlq....WEEIFRSSE...NIYFKNG 105 KAEYFNKEGYAFSISS.....KKL....TK....LEHYmmn10nnsIIVLGKRGS...HHIITSP 106 VYWGIGRNRYQLEIPE.....NFT....TRn...LPEE........YELKSTKKG...CKRYWTK 107 TYFGSDKKRYQLDVPE.....SHA....SK....ANKS........YTLEGQTKGkkpSRRYTTA 108 TIVTIRNDRFVIPVKQ.....EYR....SS....YGGI........VHDTSSSGA...TLFIEPQ 109 RIVTIRNGRYVIPVKT.....SHV....KK....IFGI........VHGTSSSGY...TTYVEPQ 110 ----NKVFGYFIEITR.....ANL....QN....FEPSefg.....YMRKQTLSN...AERFITD 111 QMYVYRDGRYLFPVKA.....SMK....NA....VRGI........VHHLSSSGA...TVFLEPD 112 ----------------.....---....--....---H........YTELSTQKN...GVYFTTK 113 KLDSSAQFGYYFRVTC.....K--....--....----........---------...------- 114 AVITQRGDRFVLPIKA.....GYK....EQ....MPGI........VHDSSASGN...TLYVEPQ 115 HLVTIRRDRYVLPVLA.....SRV....GS....VQGI........IVDASATGQ...TYFVEPA 116 DTQSHLKHGYECLLLK.....SGF....SG....AIKG........VVLERSANG...YFYLLPE 117 DTQSHLKHGYECLLLK.....SGF....SS....AIKG........VVLERSANG...YFYLLPE 118 ----------------.....---....--....----........---------...------- 119 AIVTVRNERNVIPVKA.....EYR....QD....FNGI........VHDQSASGQ...TLYIEPS 120 ----------------.....---....--....----........---------...------- 121 NFVCYKSNKYTLALKS.....NFK....GK....IKGN........IISISSSGE...TFYIEPN 122 ----------------.....---....--....----........---------...------- 123 PLITQRRSRMCVAIRA.....THK....SL....LPGGv.......VLSVSSSRA...TCFIEPK 124 DTQIHLINNLEALLVR.....GGF....NH....AIKA........KIIGRSSGG...GFYIVPL 125 DTQIHLINNLEALLVR.....GGF....NH....AIKA........KIIGRSSGG...GFYIVPL 126 ----------------.....---....--....----........---------...------- 127 HLEQHHLYGWCLRLTR.....TEA....GC....LRGRssh.....YTELSTQKN...GVYFTTK 128 QLAAEIDGRWCIQMSS.....NQL....TS....VNGLlls14ledNMCFSGSGG...GTAAEPI 129 ----------------.....---....--....----........-------ED...KLHYRSA 130 ----------------.....---....--....----........---------...---YRSA 131 ----------------.....---....--....----........---------...------- 132 ----------------.....---....--....----........---------...------- 133 --IEVFPRDYPVEVPP.....DVV....ER....LKR-........---------...------- 134 --VEVFPRDYPIEVPP.....EVV....ES....LRK-........---------...------- 135 ----------------.....---....--....----........---------...------- 136 ----------------.....---....--....----........---------...------- 137 ----------------.....---....--....----........---------...------- 138 ----------------.....---....--....----........---------...------- 139 VEFDPFIKSYPLKIDQ.....REV....ER....VKRLe.......---------...------- 140 ----------------.....---....--....----........------TKS...TASFQLP 141 ----------------.....---....--....----........---------...------- 142 ----------------.....---....--....----........---------...------- 143 ----------------.....---....--....----........---------...------- 144 ----------------.....---....--....----........---------...------- 145 ----------------.....---....--....----........---------...------- 146 ----------------.....---....--....----........---------...------- 147 ----------------.....---....--....----........---------...------- 148 ----------------.....---....--....----........---------...------- 149 ----------------.....---....--....----........---------...------- 150 ----------------.....---....--....----........---------...------- 151 ----------------.....---....--....----........---------...------- 0 490 500 510 520 530 540 | | | | | | | 1 EMKEKEREVYRLEALIRRREEEVF.LEVRERAKRQAE.ALREAARILAELDVYAALAEVA..VRY 2 EMKEKEREVYRLEALIRRREEEVF.LEVRERAKRQAE.ALREAARILAELDVYAALAEVA..VRY 3 EMKERERELYRLEALIKRREEEVF.LALRERARKEAE.ALREAARILAELDVYAALAEVA..VRH 4 EMKERERELYRLEALIKRREEEVF.LALRERARKEAE.ALREAARILAELDVYAALAEVA..VRH 5 EMKERERELYRLEALIKRREEEVF.LALRERARKEAE.ALREAARILAELDVYAALAEVA..VRH 6 EMKERERELYRLEALIKRREEEVF.IALRERARKEGE.ALREAARILAELDVYAALAEVA..VRH 7 ELKEYEDKVLTSKGKALALEKQLY.EELFDLLLPHLE.ALQQSASALAELDVLVNLAERA..YTL 8 ELKEYEDKVLTSKGKALALEKQLY.EELFDLLLPHLE.ALQQSASALAELDVLVNLAERA..YTL 9 ELKAFEDKALSAKSRALAREKALY.EELLEILIAQLA.PLQETATALAELDVLANLAERA..LNL 10 ELKEYEDKVLTSKGKALALEKQLY.EELFDLLLPHLE.ALQQSASALAELDVLVNLAERA..YTL 11 ELKEYEDKVLKSKGAALALEKQLY.DELFDLLLPHLG.SLQLASLALSELDVLVNLAERA..DTL 12 ELKAFEDKALSAQSRALAREKALY.EELLERLIGHLA.PLQDSASALAELDVLANLAERA..LNL 13 ELKAFEDKALSAQSRALAREKALY.EELLERLIGHLA.PLQDSASALAELDVLANLAERA..LNL 14 ELSSLNEEYTKNKGEYEEAQDAIV.KEIVNISSGYVE.PMQTLNDVLAHLDAIVSFAHVSnaAPV 15 ELKEYEDKVLTSKGKALALEKQLY.DELFDLLLPHLA.DLQQSANALAELDVLVNLAERA..WTL 16 ELSSLNEEYTKNKGEYEEAQDAIV.KEIVNISSGYVE.PMQTLNDVLAHLDAIVSFAHVSnaAPV 17 KLTSLNEEYTKNKTEYEEAQDAIV.KEIVNISSGYVE.PMQTLNDVLAQLDAVVSFAHVSngAPV 18 KLTSLNEEYTKNKTEYEEAQDAIV.KEIVNISSGYVE.PMQTLNDVLAQLDAVVSFAHVSngAPV 19 TIEKKLANLINAEERRDTSLKDCM.RRLFCNFDKNHK.DWQSAVECIAVLDVLLCLANYS..QGG 20 ELKEYEDKVLTSKGKALALEKQLY.DELFDLLLPHLA.DLQQSANALAELDVLVNLAERA..WTL 21 TIEKKLANLINAEERRDTSLKDCM.RRLFCNFDKNHK.DWQSAVECIAVLDVLLCLANYS..QGG 22 TIEKKLANLINAEERRDVSLKDCM.RRLFYNFDKNYK.DWQSAVECIAVLDVLLCLANYS..RGG 23 TIEKKLANLINAEERRDVSLKDCM.RRLFYNFDKNYK.DWQSAVECIAVLDVLLCLANYS..RGG 24 TIEKKLANLINAEERRDVSLKDCM.RRLFYNFDKNYK.DWQSAVECIAVLDVLLCLANYS..RGG 25 TIEKKLANLINAEERRDVSLKDCM.RRLFYNFDKNYK.DWQSAVECIAVLDVLLCLANYS..RGG 26 ELSSLNEEYTKNKGEYEEAQDAIV.KEIVNISSGYVE.PMQTVNDVLAHLDAVVSFAHVSnaAPV 27 KLSSLSEEYMRNREEYEEAQNAIV.KEIITISAGYVD.PIQTLNDVIAQLDAVVSFAHVSnsAPV 28 ELARIEGDMLEAREKSANLEYEIF.MRIREEVGKYIQ.RLQALAQGIATVDVLQSLAVVA..ETQ 29 ELKERETRILTAQADLNQLEYEIF.TEVRATVAEKAQ.PIRDVAKAVAAIDVLAGLAEVA..VYQ 30 ELKEKEALILEAENNICELEYELF.TELREKVKQYIP.RLQQLAKQMSELDALQCFATIS..ENR 31 ELKERETRILTAQADLNQLEYEIF.TEVRATVAEKAQ.PIRDVAKAVAAIDVLAGLAEVA..VYQ 32 ELQQFQDEVFSVEDKLQTLETKLF.KELCCYILQHRD.LILELSTTIADLDYVISLAELA..AEY 33 ELKAFEDKVLTAQEQALALEKQLF.DGVLKNLQTALP.QLQKAAKAAAALDVLSTFSALA..KER 34 ELKEKEALILEAENNICELEYELF.TELREKVKQYIP.RLQQLAKQMSELDALQCFATIS..ENR 35 FIVESYRRLNQLREQLVLDCNAEW.LGFLENFGEHYH.TLCKAVDHLATVDCIFSLAKVA..KQG 36 FIVENYRHLNQLREQLVLDCSAEW.LDFLEKFSEHYH.SLCKAVHHLATVDCIFSLAKVA..KQG 37 ELQNLENELVNAQTLVIRLEKELY.TDICRKVIEKSS.YLKILANSLSGLDVFCNFAYIA..DEY 38 FIVESYRRLNQLREQLVLDCNAEW.LGFLENFGEHYH.TLCKAVDHLATVDCIFSLAKVA..KQG 39 ELKAFEDKVLSARDRALVREKLLY.EQLLDTVGAQLE.PLKRCAAALSELDVLVCFAERA..QTL 40 FIVESYRRLNQLREQLVLDCNAEW.LGFLENFGEHYH.TLCKAVDHLATVDCIFSLAKVA..KQG 41 FIVENYRHLNQLREQLVLDCSAEW.LDFLEKFSEHYH.SLCKAVHHLATVDCIFSLAKVA..KQG 42 ELKAFEDKVLTAQEQALALEKQLF.DGVLKNLQTALP.QLQKAAKAAAALDVLSTFSALA..KER 43 ELKEFETKIMAAKERIEELEKELF.KSVCEEVKKHKE.VLLEISEDLAKIDALSTLAYDA..IMY 44 ELQQFQDEVFSVEDKLQTLETKLF.KELCFYIVEHRD.LILKLSTAVADLDYVVSLAELA..AEY 45 ELQQFQDDMSNISEKLQTLETQFF.KDLCSHILQLRT.EILALSQSLADLDYIISLADLA..HAQ 46 ELAELETKIANAADRALAIELETF.EAMVREVVAEAE.AIKAAALALATIDVSAGLAVLA..EEQ 47 ELQQFQDDMSNISEKLQTLETQFF.KDLCSHILQLRT.EILALSQSLADLDYIISLADLA..HAQ 48 ELQRLEEKILSAQTRINELEYELY.RELREEVVKELD.KVGNNATLIGEVDYIQSLAWLA..LEK 49 ELKEFETKIMAAKERIEELEKELF.TSVCEEVKKHKE.VLLEISEDLAKIDALSTLAYDA..IMY 50 QLSELEAKLARAREGLVSFEQELF.ADIRRTVCSHTQ.LLRTNAARVAQLDVLQSFAHAA..LQH 51 KLEGYADEFASCRTRYEEQQLSIV.EEIIHVAVGYAA.PLTLLNNELAQLDCLVSFAIAArsAPT 52 KIQSLLIELSSHEENLTISSEKIY.RSFLSRISEHYN.ELRNVTTVLGTLDCLISFARIS..SQS 53 ELQRLEEKILSAQTRINDLEYELY.KELRERVVKELD.KVGNNASAVAEVDFIQSLAQIA..YEK 54 KIQSLLIELSSHEENLTISSEKIY.RSFLSRISEHYN.ELRNVTTVLGTLDCLISFARIS..SQS 55 KLTSLNEEYTKNKTEYEEAQDAIV.KEIVNISSGYVE.PMQTLNDVLAQLDAVVSFAHVSngAPV 56 ELRKKIKKLLEAEELHLAIMSRMQ.EKFYIRFDSNYE.QWLALIKYTASIDCFFSLSQAA..AAL 57 TIKKLLKELSQAKSEKESALKSIS.QRLIGRFCEHQE.KWRQLVSATAELDVLISLAFAS..DSY 58 KLKKLGDQYQSVVDDYRSCQKELV.DRVVETVTSFSE.VFEDLAGLLSEMDVLLSFADLAasCPT 59 KLKKLGDQYQSVVDDYRSCQKELV.DRVVETVTSFSE.VFEDLAGLLSEMDVLLSFADLAasCPT 60 KLEGYADEFASCRTRYEEQQLSIV.EEIIHVAVGYAA.PLTLLNNELAQLDCLVSFAIAArsAPT 61 KLISLEVDINNAEDNVVAFEQEIF.DEIASNVVMHNK.VLKKVAEFFAYIDLVVNFGYLA..KKN 62 TIKKLLKELSQAKSEKESALKSIS.QRLIGRFCEHQE.KWRQLVSATAELDVLISLAFAS..DSY 63 EIVAGLDELALATEHLAIVNRASW.DSFLKSFSRYYT.DFKAAVQALAALDCLHSLSTLS..RNK 64 KLEGYADEFASCRTRYEEQQLSIV.EEIIHVAVGYAA.PLTLLNNELAQLDCLVSFAIAArsAPT 65 KLKNLSDQYQALFGEYTSCQKKVV.GDVVRVSGTFSE.VFENFAAVLSELDVLQSFADLAtsCPV 66 EVRALARSMAEAKEIHKTLEEDLK.NRLCQKFDAHYNtIWMPTIQAISNIDCLLAITRTS..EYL 67 RTQKLTQKLEYYKDLLIRESELQY.KEFLNKITAEYT.ELRKITLNLAQYDCILSLAATS..CNV 68 EVRALARSMAEAKEIHKTLEEDLK.NRLCQKFDAHYNtIWMPTIQAISNIDCLLAITRTS..EYL 69 TLQALRREFDQLSQNYNRTQSSLV.NEVVGVAASYCP.VLERLAAVLAHLDVIVSFAHCSvhAPI 70 IWTDLGHELELLNLKIRNEEANII.DLFKRKFIDRSN.VVRQVATTLGYLDTLSSFAVLA..NER 71 GWTSLGMDLENTKLHIHQEEQRVL.KSITDEIVSHHK.TLRSLANALDELDISTSLATLA..QEQ 72 RTQKLTQKLEYYKDLLIRESELQY.KEFLNKITAEYT.ELRKITLNLAQYDCILSLAATS..CNV 73 IWTDLGHELELLNLKIRNEEANII.DLFKRKFIDRSN.EVRQVATTLGYLDTLSSFAVLA..NER 74 RLHSLNNSYMDHQKSYRYHQNGLA.REVIKIAATYGP.PLEAIGQVIAHLDVILSFAHAStvAVI 75 DSEQLVAALDAVEKEKSKLGDDAT.RRVFEQFGHKNP.IWLETVKLVSSFDVLTSLALFAksSPF 76 QLKSIANETNILQKEYDKQQSALV.REIINITLTYTP.VFEKLSLVLAHLDVIASFAHTSsyAPI 77 QLKSIANETNILQKEYDKQQSALV.REIINITLTYTP.VFEKLSLVLAHLDVIASFAHTSsyAPI 78 -------------SDVNANGANDL.AALMDVFIGKAS.EWSLVINAVSTIDVLRSFAAMTl.SSF 79 -------------SDVNANGANDL.AALMDVFIGKAS.EWSLVINAVSTIDVLRSFAAMTl.SSF 80 EIVAGLDELALATEHLAIVNRASW.DSFLKSFSRYYT.DFKAAVQALAALDCLHSLSTLS..RNK 81 EIVAGLDELALATEHLAIVNRASW.DSFLKSFSRYYT.DFKAAVQALAALDCLHSLSTLS..RNK 82 --------------DVTDENAETL.TILIELFIERAT.QWSEVIHTISCLDVLRSFAIAAslSAG 83 RTKELDALLGDLHCEIRDQETLLM.YQLQCQVLARAA.VLTRVLDLASRLDVLLALASAA..RDY 84 RTKELDALLGDLHCEIRDQETLLM.YQLQCQVLARAA.VLTRVLDLASRLDVLLALASAA..RDY 85 RTKELDALLGDLHCEIRDQETLLM.YQLQCQVLARAA.VLTRVLDLASRLDVLLALASAA..RDY 86 ELSDINDEFLEFHLKYTRAEEEVI.SMLCKKAEEFIP.LIPAMAQLIATLDVFVSLSTFA..ATS 87 FIVESYRRLNQLREQLVLDCNAEW.LGFLENFGEHYH.TLCKAVDHLATVDCIFSLAKVA..KQG 88 GWTSLGMDLENTKLHIHQEEQRVL.KSITDEIVSHHK.TLRSLANALDELDISTSLATLA..QEQ 89 TTSRLDDEFGDILMRLIDSQTAII.LTLKTRVMKKKR.SIIKLLSIASRIDVLISFGLIA..AQN 90 TTSRLDDEFGDILMRLIDSQTAII.LTLKTRVMKKKR.SIIKLLSIASRIDVLISFGLIA..AQN 91 RTKELDTLLGDLHCEIRDQETLLM.YQLQCQVLARAS.VLTRVLDLASRLDVLLALASAA..RDY 92 RTKELDTLLGDLHCEIRDQETLLM.YQLQCQVLARAS.VLTRVLDLASRLDVLLALASAA..RDY 93 DLIKMNERCQESLREIYHMTYMIV.CKLLSEIYEHIH.CLYKLSDTVSMLDMLLSFAHAC..TLS 94 DLIKMNERCQESLREIYHMTYMIV.CKLLSEIYEHIH.CLYKLSDTVSMLDMLLSFAHAC..TLS 95 TTSRLDDEFGDILMRLIDSQTAII.LTLKTRVMKKKR.SIIKLLSIASRIDVLISFGLIA..AQN 96 ELKELILELSKAESEKESKLKAIL.QNLIQLFVEHHT.EWRQLVSVVAELDVLTSLAIASgyFEG 97 ELKAFEDKALSAKSRALAREKMLY.DALLETLISHLA.PLQDSAAALAELDVLINLAERA..LNL 98 NIIKKNARLKEVMEEILLLSEETV.DELLDKIATHIS.ELFMIAEAVAILDLVCSFTYNL..KEN 99 NIIKKNARLKEVMEEILLLSEETV.DELLDKIATHIS.ELFMIAEAVAILDLVCSFTYNL..KEN 100 KVIAYNDRLEQVVAEMFLASDVIV.CDMIEEMQPMIP.VLYYAMDALSSIDFLCGLATYS..DLR 101 ELMKQSSRYNDIVSEITTLNSTII.HDMYTSINSYTP.ILLMVSEAIGTLDLLCSFAYFT..SLQ 102 TIHKVSIELNELEEQINIYVKQTYhQELKRLYFSYSE.LFLPLVNMISRLDVALSGAITA..IKF 103 RVLELDETYGDIYGAISDFEIEIL.FSLQEQILRRKT.QLTAYNILLSELEILLSFAQVS..AER 104 RVLELDETYGDIYGAISDFEIEIL.FSLQEQILRRKT.QLTAYNILLSELEILLSFAQVS..AER 105 TIHKVSIELNELEEQINIYVKQTYhQELKRLYFSYSE.LFLPLVNMISRLDVALSGAITA..IKF 106 TIEKKLANLINAEERRDVSLKDCM.RRLFYNFDKNYK.DWQSAVECIAVL----------..--- 107 ETRALLKDMQHAEDTRNMVLKDLA.RRLFEKFSNHYD.QWKQCIDCVANLDVLGSLAEYA..GQQ 108 AIVDMNNSLQQAKVKEKQEIERIL.RVLTEKTAEYTE.ELFLDLQVLQTLDFIFAKARYA..KAV 109 FVIHLNNKLTELKQKEEEEVRKVL.QRITEYIGDYAK.ELLESFEACVEVDFQQCKYRFS..KLV 110 ELKEKEDIILGAEDKAIELEYQLF.VQLREEVKKYTE.RLQQQAKIISELDCLQSFAEIA..QKY 111 EFVELNNRVRLLEEEERLEISRIL.RQLTNILLSRLN.DLERNVELIARFDSLYARVKFA..REF 112 RLHSLNNSYMDHQKSYRYHQNGLA.REVIKIAATYGP.PLEAIGQVIAHLDVILSFAHAStvAVI 113 ------------------------.------------.----------------------..--- 114 AIVELGNKLRQARRQEQTEEERIL.RQLSDQVLEVLL.DLEHLLAIATRLDLATARVRYS..FWL 115 AVTQLNNELTRLILDEEAEVRRIL.TELSALLAQD-S.AVPMTLATIGELDLIASKAKLA..RDW 116 SAQKIAQKIAQIGNEIDCCIVEMC.QTLSHSLQKHLL.FLKFLFKEFDFLDSLQARLNFA..KAY 117 SAQKIAQKIAQIGNEIDCCIVEMC.QTLSRSLQKHLL.FLKFLFKEFDFLDSLQARLNFA..KAY 118 ---------------------ETF.EAMVREVVAEAE.AIKAAALALATIDVSAGLAVLA..EEQ 119 SVVEMNNQISRLRHDEAIEKERIL.TQLTGYVAADKD.ALLVAEQVMGQLDFLIAKARYS..RSI 120 ------------------------.------------.----------------------..--- 121 DIVNANNRLNYLSLEKERIILKIL.RNLSAKVHSNIV.LLDNLYNNFLYYDSLKARAIYG..IKT 122 ------------------------.------------.----------------------..--- 123 EAVELNNMEVRHANSEKAEEMAIL.SILTSEVVMAQR.EILHLLDRILELDIAFARASHA..NWI 124 SVENLQNDIEKIKNQKEEIYYEYA.KNFSAFLAKNLP.FLKFINTAFDLFDHYSARVLLA..KKR 125 SVENLQNDIEKIKIKKKKFIMKYA.KNFSAFLAKNLP.FLKFINTAFDLFDHYSARVLLAkkKDF 126 ------------------------.------------.----------------------..--- 127 RLHSLNNS----------------.------------.----------------------..--- 128 AAVSMNDDLQSARASVAKAEAEIL.SMLTEKIN----.----------------ARATYS..RAY 129 RTKELDTLLGDLHCEIRDQETLLM.YQLQCQVLARAS.VLTRVLDLASRLDVLLALASAA..RDY 130 RTKELDALLGDLHCEIRDQETLLM.YQLQCQVLARAA.VLTRVLDLASRLDVLLALASAA..RDY 131 ------------------------.------------.----------------------..--- 132 ------------------------.------------.----------------------..--- 133 ----------SVERELKIELYMRA.REIVPRIIPYIQ.GLKEEIERAYELEFILALKRFS..R-- 134 ----------SVERELKLELYLKS.REVLEDILPYLP.KLKEEIEKAYELEFIIALKRFS..K-- 135 ------------------------.------------.----------------------..--- 136 ------------------------.------------.----------------------..--- 137 ------------------------.------------.----------------------..--- 138 ------------------------.------------.----------------------..--- 139 ------------AASRNLREFEVK.VDAATRLGELRG.AVEGEIRDIMEFDYRLALGLFA..HEY 140 GWTSLGMDLENTKLHIHQEEQRVL.KSITDEIVSHHK.TLRSLANALDELDISTSLATLA..QEQ 141 ------------------------.------------.----------------------..--- 142 ------------------------.------------.----------------------..--- 143 ------------------------.------------.----------------------..--- 144 ------------------------.------------.----------------------..--- 145 ------------------------.------------.----------------------..--- 146 ------------------------.------------.----------------------..--- 147 ------------------------.------------.----------------------..--- 148 ------------------------.------------.----------------------..--- 149 ------------------------.------------.----------------------..--- 150 ------------------------.------------.----------------------..--- 151 ------------------------.------------.----------------------..--- 550 560 570 | | | 1 G..YVRPRFG........DR........LQIRAGRHPVVERR........T........EFVPND 2 G..YVRPRFG........DR........LQIRAGRHPVVERR........T........EFVPND 3 G..YTRPRFG........ER........LRIRAGRHPVVERR........T........AFVPND 4 G..YTRPRFG........ER........LRIRAGRHPVVERR........T........AFVPND 5 G..YTRPRFG........ER........LRIRAGRHPVVERR........T........AFVPND 6 G..YTRPRFG........ER........LRIRAGRHPVVRRR........T........AFVPND 7 N..YTCPTFI........DKpg......IRITEGRHPVVEQVln......E........PFIANP 8 N..YTCPTFI........DKpg......IRITEGRHPVVEQVln......E........PFIANP 9 D..FNRPRFV........EEpc......LRIRQGRHPVVEQVld......T........PFVAND 10 N..YTCPTFI........DKpg......IRITEGRHPVVEQVln......E........PFIANP 11 N..YVMPTFC........DEvs......VKIKNGRHPVVEQVlk......D........PFIANP 12 D..LNRPRFV........EHtc......LHIEQGRHPVVEQVle......T........PFVAND 13 D..LNRPRFV........EHtc......LHIEQGRHPVVEQVle......T........PFVAND 14 P..YVRPVIL........EKgkgr....IILKASRHACVEVQde......V........AFIPND 15 N..YTCPTFT........DKpg......IRITEGRHPVVEQVln......E........PFIANP 16 P..YVRPVIL........EKgkgr....IILKASRHACVEVQde......V........AFIPND 17 P..YVRPAIL........EKgqgr....IILKASRHACVEVQde......I........AFIPND 18 P..YVRPAIL........EKgqgr....IILKASRHACVEVQde......I........AFIPND 19 DgpMCRPEIVlpg.....--edthpf..LEFKGSRHPCITKTffg.....D........DFIPND 20 N..YTCPTFT........DKpg......IRITEGRHPVVEQVln......E........PFIANP 21 DgpMCRPEIVlpg.....--edthpf..LEFKGSRHPCITKTffg.....D........DFIPND 22 DgpMCRPVILlp......--edtppf..LELKGSRHPCITKTffg.....D........DFIPND 23 DgpMCRPVILlp......--edtppf..LELKGSRHPCITKTffg.....D........DFIPND 24 DgpMCRPVILlp......--edtppf..LELKGSRHPCITKTffg.....D........DFIPND 25 DgpMCRPVILlp......--edtppf..LELKGSRHPCITKTffg.....D........DFIPND 26 P..YVRPVIL........EKgkgr....IIVKASRHACVEVQhd......V........AFIPND 27 P..YVRPVIL........EKgqgr....IVLHSARHPCIEMQdd......V........AFIPND 28 H..LIRPEFG........DDsq......IDIRKGRHAVVEKVmga.....Q........TYIPNT 29 G..YCRPIMQ........MEpgl.....IDIEAGRHPVVEQSlga.....G........FFVAND 30 H..YTKPEFS........KDe.......VEVIEGRHPVVEKVmds.....Q........EYVPNN 31 G..YCRPIMQ........MEpgl.....IDIEAGRHPVVEQSlga.....G........FFVAND 32 D..YRRPLVD........HSda......LSITKGMHPVALTLldr.....G........TFIPND 33 N..FVRPEFA........DYpa......IHIENGRHPVVEQQv.......R........HFTANH 34 H..YTKPEFS........KDe.......VEVIEGRHPVVEKVmds.....Q........EYVPNN 35 N..YCRPTLQ........EEkk......IIIKNGRHPMIDVLlgeq....D........QFVPNS 36 D..YCRPTVQ........EErk......IVIKNGRHPVIDVLlgeq....D........QYVPNN 37 D..YTKPEFT........NDls......FDIVKGRHPVVEAAlrkts...K........SFVYND 38 N..YCRPTLQ........EEkk......IIIKNGRHPMIDVLlgeq....D........QFVPNS 39 D..WVRPELE........HTsc......LHIEGGRHPVVEAVre......Q........RFEPND 40 N..YCRPTLQ........EEkk......IIIKNGRHPMIDVLlgeq....D........QFVPNS 41 D..YCRPTVQ........EErk......IVIKNGRHPVIDVLlgeq....D........QYVPNN 42 N..FVRPEFA........DYpv......IHIENGRHPVVEQQv.......R........HFTANH 43 N..YTKPVFS........EDr.......LEIKGGRHPVVERFt.......Q........NFVEND 44 D..YRRPLVD........HSda......LSITKGMHPVALTLldk.....G........TFIPND 45 G..YCRPRVD........MSdt......LCIYRGCHPVAKTLvdt.....G........KFIPND 46 N..YTRPTVD........RSrm......FAIDGGRHPVVEQAlrrqaa..N........PFVANG 47 G..YCRPHVD........MSdt......LCIYRGCHPVAKTLvdt.....G........KFIPND 48 G..WVKPEVH........EGye......LIIEEGKHPVIEEFt.......K........NYVPND 49 N..YTKPVFS........EDr.......LEIKGGRHPVVERFt.......Q........NFVEND 50 G..WSQPVFI........KDga......LRITGGRHPVVELHlps.....G........EFVPND 51 P..YVRPKML........EEgare....LVLEDVRHPCLELQeh......V........NFIANS 52 G..YTRPEFS........DKe.......LLIHESRHPMIELLsd......K........SFVPNH 53 D..WAKPQIH........EGye......LIIEEGRHPVIEEFv.......E........NYVPND 54 G..YTRPEFS........DKe.......LLIHESRHPMIELLsd......K........SFVPNH 55 P..YVRPAIL........EKgqgr....IILKASRHACVEVQde......I........AFIPND 56 GepYCRPEII........EQkdgh....LYFEELRHPCINASaa......S........TFVPND 57 EgvRCRPVIS........GStsdgvph.LSATGLGHPVLRGDslgr....G........SFVPNN 58 P..YCRPEIT........SSdagd....IVLEGSRHPCVEAQdw......V........NFIPND 59 P..YCRPEIT........SLdagd....IVLEGSRHPCVEAQdw......V........NFIPND 60 P..YVRPKML........EEgare....LVLEDVRHPCLELQeh......V........NFIANS 61 E..YKRPVLT........SGke......ILLEKSRHPVVEHYtknt....E........IFTENF 62 EgvRCRPVIS........GStsdgvph.LSATGLGHPVLRGDslgr....G........SFVPNN 63 N..YVRPEFV........DDcepve...INIQSGRHPVLETIlq......D........NFVPND 64 P..YVRPKML........EEgare....LVLEDVRHPCLELQeh......V........NFIANS 65 P..YVRPDIT........ASdegd....IVLLGSRHPCLEAQdg......V........NFIPND 66 GapSCRPTIV........DEvds12ngfLKFKSLRHPCFNLGatta....K........DFIPND 67 N..YVRPTFV........NGqqa.....IIAKNARNPIIESLd.......V........HYVPND 68 GapSCRPTIV........DEvds12ngfLKFKSLRHPCFNLGatta....K........DFIPND 69 S..YVRPKIH........PRgtgr....TVLTEARHPCMEVQdd......V........TFITND 70 N..LVCPKVD........ESnk......LEVVNGRHLMVEEGlsarsl..E........TFTANN 71 D..FVRPVVD........DSha......HTVIQGRHPIVEKGlshkl...I........PFTPND 72 N..YVRPTFV........NGqqa.....IIAKNARNPIIESLd.......V........HYVPND 73 N..LVCPKVD........ESnk......LEVVNGRHLMVEEGlsarsl..E........TFTANN 74 P..YVRPNIVdss24edt--pnf17carLYLKQARHPCLEAQdd......V........KFIPND 75 E..MCMPEFD........FNatdpy...LIVDKGVHPCLALQsrnevtqtT........SFIANS 76 P..YIRPKLH........PMdserr...THLISSRHPVLEMQdd......I........SFISND 77 P..YIRPKLH........PMdserr...THLISSRHPVLEMQdd......I........SFISND 78 Ga.MCRPQVL........LKddvpv...LRMKGLWHPYAFAGna......N........SLVPND 79 Ga.MCRPQVL........LKddvpv...LRMKGLWHPYAFAGna......N........SLVPND 80 N..YVRPEFV........DDcepve...INIQSGRHPVLETIlq......D........NFVPND 81 N..YVRPEFV........DDcepve...INIQSGRHPVLETIlq......D........NFVPND 82 S..MARPVIF........PEsea14gpiLKIQGLWHPFAVAAdg......Q........LPVPND 83 G..YSRPRYS........PQvlg.....VRIQNGRHPLMELCa.......R........TFVPNS 84 G..YSRPRYS........PQvlg.....VRIQNGRHPLMELCa.......R........TFVPNS 85 G..YSRPRYS........PQvlg.....VRIQNGRHPLMELCa.......R........TFVPNS 86 SgiYTRPNLL........PLgskr....LELKQCRHPVIEGNse......K........PFIPND 87 N..YCRPTLQ........EEkk......IIIKNGRHPMIDVLlgeq....D........QFVPNS 88 D..FVRPVVD........DSha......HTVIQGRHPIVEKGlshkl...I........PFTPND 89 G..WNCPALV........DEpv......IEAVELYHPISVLVvk......K........SFVPNQ 90 G..WNCPALV........DEpv......IEAVELYHPISVLVvk......K........SFVPNQ 91 G..YSRPHYS........PCihg.....VRIRNGRHPLMELCa.......R........TFVPNS 92 G..YSRPHYS........PCihg.....VRIRNGRHPLMELCa.......R........TFVPNS 93 D..YVRPEFT........DT........LAIKQGWHPILEKIsa......E........KPIANN 94 D..YVRPEFT........DT........LAIKQGWHPILEKIsa......E........KPIANN 95 G..WNCPALV........DEpv......IEAVELYHPISVLVvk......K........SFVPNQ 96 P..SCCPTIK........ESngtddtptFHARNLGHPILRSDslgk....G........SFVPND 97 D..LNCPRFV........DEpc......LRIEQGRHPVVEQVlt......T........PFVAND 98 N..YTIPIFT........NN........LLIRDSRHPLLEKVl.......K........NFVPNT 99 N..YTIPIFT........NN........LLIRDSRHPLLEKVl.......K........NFVPNT 100 D..TCKPTFG........PS........FSISQGRHPILDWDds......E........KTITND 101 KdsYTCPEFA........KE........VTIMRSLHPILGGNn.......S........NFVANN 102 N..YVEPCLTlakt....--qqtkgf..IERANLRHPLVEQLntq.....E........ECIAHN 103 N..YAEPQLV........EDeci.....LEIINGRHALYETFl.......D........NYIPNS 104 N..YAEPQLV........EDeci.....LEIINGRHALYETFl.......D........NYIPNS 105 N..YVEPCLTlakt....--qqtkgf..IEAANLRHPLVEQLntq.....E........ECIAHN 106 -..-------........--........--------------........-........------ 107 Mv.ICVPELV........SDadqpf...IQLEEGYHPCANA-........S........TYIPNG 108 K..ATKPIMN........DTgf......IRLKKARHPLLPP-........D........QVVAND 109 E..GSFPDFG........EW........VELYEARHPVLVLVk.......E........DVVPVG 110 N..YTRPSFS........ENkt......LELVESRHPVVERVmdy.....N........DYVPNN 111 N..GTVVKPS........SR........IRLVNARHPLIPK-........E........RVVPIN 112 P..YVRPNIVdss24edt--pnf17carLYLKQARHPCLEAQdd......V........KFIPND 113 -..-------........--........--------------........-........------ 114 G..AHPPQWL........TPgdekp...ITLRQLRHPLLHWQaekegg..P........AVVPIT 115 R..LNRPEAA........PDgl......YDLHEARHPLI---........E........NPVAND 116 NleFVMPSFT........QKk.......MILENFSHPIL---........K........EPKPLN 117 NleFVMPSFT........QKk.......MILENFSHPIL---........K........EPKPLN 118 N..YTRPTVD........RSrm......FAIDGGRHPVVEQAlrrqaa..N........PFVANG 119 K..GTKPIFK........EErt......VYLPKAYHPLLNR-........E........TVVANT 120 -..-------........--........--------------........-........------ 121 K..GVFPEIS........NV........LNIFDAHHPLL---........K........DSKAIT 122 -..-------........--........--------------........-........------ 123 N..GVYPNVT........SEhtktpglaVDIDSAQHPLLLGSvlg9nggdI........FPVPVD 124 DfeFVLCDQS........TD........LVLKNFAHPAL---........K........NPKSVS 125 E..FVLCDQS........TD........LVLKNFAHPAL---........K........NPKSVS 126 -..-------........--........--------------........-........------ 127 -..-------........--........--------------........-........------ 128 G..GAHPDIYlpp24pse--kpl9kewlLYLPRCYHPLLLYQhkkgi...-rkt20sgaPPIPAD 129 G..YSRPHYS........PCihg.....VRIRNGRHPLMELCa.......R........TFVPNS 130 G..YSRPRYS........PQvlg.....VRIQNGRHPLMELCa.......R........TFVPNS 131 -..-------........--........--------------........-........------ 132 -..-------........--........--------------........-........------ 133 G..FTFPKIE........EGg.......IGFIKGRNLFI---........E........NPQPVS 134 G..FTFPKIE........EGg.......IGFVKGKNLFI---........E........NPQPVS 135 -..-------........--........--------------........-........------ 136 -..-------........--........--------------........-........------ 137 -..-------........--........--------------........-........------ 138 -..-------........--........--------------........-........------ 139 E..LTEPEFG........DE........ISLRGALHLNLVGS........R........KPQRVD 140 D..FVRPVVD........DSha......HTVIQGRHPIVEKGlshkl...I........PFTPND 141 -..-------........--........--------------........-........------ 142 -..-------........--........--------------........-........------ 143 -..-------........--........--------------........-........------ 144 -..-------........--........--------------........-........------ 145 -..-------........--........--------------........-........------ 146 -..-------........--........--------------........-........------ 147 -..-------........--........--------------........-........------ 148 -..-------........--........--------------........-........------ 149 -..-------........--........--------------........-........------ 150 -..-------........--........--------------........-........------ 151 -..-------........--........--------------........-........------ 580 590 600 610 620 | | | | | 1 LEMAHE........LVLITGPNMAGKSTFLRQTALIALLAQ..VGSFVPA.EEA.HLPLFDGIYT 2 LEMAHE........LVLITGPNMAGKSTFLRQTALIALLAQ..VGSFVPA.EEA.HLPLFDGIYT 3 LEMAHE........LVLVTGPNMAGKSTFLRQTALIALLAQ..IGSFVPA.EEA.ELPLFDGIYT 4 LEMAHE........LVLVTGPNMAGKSTFLRQTALIALLAQ..IGSFVPA.EEA.ELPLFDGIYT 5 LEMAHE........LVLVTGPNMAGKSTFLRQTALIALLAQ..IGSFVPA.EEA.ELPLFDGIYT 6 LEMAHE........LVRVTGPNMAGKSTFLRQTALIALLAQ..IGSFVPA.EEA.ELPLFDGIYT 7 LNLSPQrr......MLIITGPNMGGKSTYMRQTALIALMAY..IGSYVPA.QKV.EIGPIDRIFT 8 LNLSPQrr......MLIITGPNMGGKSTYMRQTALIALMAY..IGSYVPA.QKV.EIGPIDRIFT 9 LELDDNtr......MLIITGPNMGGKSTYMRQTALIVLLAH..IGSFVPA.QSC.ELSLVDRIFT 10 LNLSPQrr......MLIITGPNMGGKSTYMRQTALIALMAY..IGSYVPA.QKV.EIGPIDRIFT 11 VELNHNrh......LLVITGPNMGGKSTYMRQTALITLLAY..IGSFVPA.DSA.RIGPIDRIFT 12 LALDADtr......MLVITGPNMGGKSTYMRQTALIVLLAH..IGSFVPA.ARC.ELSLAVRIFT 13 LALDADtr......MLVITGPNMGGKSTYMRQTALIVLLAH..IGSFVPA.ARC.ELSLVDRIFT 14 VHFEKDkqm.....FHIITGPNMGGKSTYIRQTGVIVLMAQ..IGCFVPC.ESA.EVSIVDCILA 15 LNLSPQrr......MLIITGPNMGGKSTYMRQTALIALLAY..IGSYVPA.QNV.EIGPIDRIFT 16 VHFEKDkqm.....FHIITGPNMGGKSTYIRQTGVIVLMAQ..IGCFVPC.ESA.EVSIVDCILA 17 VYFEKDkqm.....FHIITGPNMGGKSTYIRQTGVIVLMAQ..IGCFVPC.ESA.EVSIVDCILA 18 VYFEKDkqm.....FHIITGPNMGGKSTYIRQTGVIVLMAQ..IGCFVPC.ESA.EVSIVDCILA 19 ILIGCEeea10kayCVLVTGPNMGGKSTLIRQAGLLAVMAQ..LGCYVPA.EKC.RLTPVDRVFT 20 LNLSPQrr......MLIITGPNMGGKSTYMRQTALIALLAY..IGSYVPA.QNV.EIGPIDRIFT 21 ILIGCEeea10kayCVLVTGPNMGGKSTLIRQAGLLAVMAQ..LGCYVPA.EKC.RLTPVDRVFT 22 ILIGCEeee10kayCVLVTGPNMGGKSTLMRQAGLLAVMAQ..MGCYVPA.EVC.RLTPIDRVFT 23 ILIGCEeee10kayCVLVTGPNMGGKSTLMRQAGLLAVMAQ..MGCYVPA.EVC.RLTPIDRVFT 24 ILIGCEeee10kayCVLVTGPNMGGKSTLMRQAGLLAVMAQ..MGCYVPA.EVC.RLTPIDRVFT 25 ILIGCEeee10kayCVLVTGPNMGGKSTLMRQAGLLAVMAQ..MGCYVPA.EVC.RLTPIDRVFT 26 VHFEKDkqm.....FHIITGPNMGGKSTYIRQTGVIVLMAQ..IGCFVPC.ESA.EVSIVDCILA 27 ITFEKEkqm.....FHIITGPNMGGKSTYIRQTGVIVLMAQ..IGCFVPC.DSA.QVSIVDCILA 28 IQMAEDts......IQLVTGPNMSGKSTYMRQLAMTAVMAQ..LGSYVPA.ESA.HLPIFDAIFT 29 TQLGHDhwhpd...LVILTGPNASGKSCYLRQVGLIQLMAQ..TGSFIPA.KTA.TLSICDRIFT 30 CMMGDNrq......MLLITGPNMSGKSTYMRQIALISIMAQ..IGCFVPA.KKA.VLPIFDQIFT 31 TQLGHDhwhpd...LVILTGPNASGKSCYLRQVGLIQLMAQ..TGSFIPA.KTA.TLSICDRIFT 32 TIMHSAqtr.....MILLTGPNMAGKSTYIRQIALLVIMAQ..MGSFIPA.RSA.HIGIIDKIFT 33 TNLDHKhr......LMLLTGPNMGGKSTYMRQVALIVLLAH..TGCFVPA.DAA.TIGPIDQIFT 34 CMMGDNrq......MLLITGPNMSGKSTYMRQIALISIMAQ..IGCFVPA.KKA.VLPIFDQIFT 35 TSLSDSer......VMIITGPNMGGKSSYIKQVALVTIMAQ..IGSYVPA.EEA.TIGIVDGIFT 36 TDLSEDser.....VMIITGPNMGGKSSYIKQVALITIMAQ..IGSYVPA.EEA.TIGIVDGIFT 37 CHLSEAer......IWLITGPNMAGKSTYLRQNAIITIIAQ..IGSFVPA.KSA.KIGVVDKIFS 38 TSLSDSer......VMIITGPNMGGKSSYIKQVTLVTIMAQ..IGSYVPA.EEA.TIGIVDGIFT 39 LDLHPErr......MLVITGPNMGGKSTYMRQNALIVLLAY..IGSYVPA.SRA.LIGPIDRIMT 40 TSLSDSer......VMIITGPNMGGKSSYIKQVALVTIMAQ..IGSYVPA.EEA.TIGIVDGIFT 41 TDLSEDser.....VMIITGPNMGGKSSYIKQVALITIMAQ..IGSYVPA.EEA.TIGIVDGIFT 42 TDLDHKhr......LMLLTGPNMGGKSTYMRQVALIVLLAH..TGCFVPA.DAA.TIGPIDQIFT 43 IYMDNEkr......FVVITGPNMSGKSTFIRQVGLISLMAQ..IGSFVPA.QKA.ILPVFDRIFT 44 TVMHSAqtr.....MILLTGPNMAGKSTYIRQIALLVIMAQ..MGSFIPA.RSA.HIGIVDKIFT 45 TEMRGSqtr.....MILLTGPNMAGKSTYIRQIALLVIMAQ..MGSYIPA.KSA.HIGVIDKIFT 46 CDLSPPngeqgga.IWLLTGPNMGGKSTFLRQNALIAIMAQ..TGSFVPA.AAA.HIGVVDRLFS 47 TEMRGSqtr.....MILLTGPNMAGKSTYIRQIALLVIMAQ..MGSYIPA.KSA.HIGVIDKIFT 48 TKLTEEef......IHVITGPNMAGKSSYIRQVGVLTLLAH..TGSFLPV.KSA.RIPLVDAIFT 49 IYMDNEkr......FVVITGPNMSGKSTFIRQVGLISLMAQ..IGSFVPA.QKA.ILPVFDRIFT 50 LTLSSSehavlpr.FALITGPNMAGKSTFLRQTALICLIAQ..VGSFVPA.EKA.ELTPVDRIFC 51 VDFKKEecn.....MFIITGPNMGGKSTYIRSVGTAVLMAH..IGAFVPC.SLA.TISMVDSILG 52 IHLSSDgvr.....CLLITGPNMGGKSSFVKQLALSAIMAQ..SGCFVPA.KSA.LLPIFDSILI 53 TKLDRDsf......IHVITGPNMAGKSSYIRQVGVLTLLSH..IGSFIPA.RRA.KIPVVDALFT 54 IHLSSDgvr.....CLLITGPNMGGKSSFVKQLALSAIMAQ..SGCFVPA.KSA.LLPIFDSILI 55 VYFEKDkqm.....FHIITGPNMGGKSTYIRQTGVIVLMAQ..IGCFVPC.ESA.EVSIVDCILA 56 VVLGGEspn.....MIVLTGPNMAGKSTLLRQVCIAVIMAQ..LGCWVPA.KRA.SITPMTSIYT 57 VKIGGAekas....FILLTGPNMGGKSTLLRQVCLAVILAQ..IGADVPA.ETF.EVSPVDKICV 58 CRLMRGksw.....FQIVTGPNMGGKSTFIRQVGVIVLMAQ..VGSFVPC.DKA.SISIRDCIFA 59 CRLMRGksw.....FQIVTGPNMGGKSTFIRQVGVIVLMAQ..VGSFVPC.DKA.SISIRDCIFA 60 VDFKKEecn.....MFIITGPNMGGKSTYIRSVGTAVLMAH..IGAFVPC.SLA.TISMVDSILG 61 VRINKEky......FCLITGPNMAGKSTYLRQVALITLMAH..IGSFVPA.SKA.LIGITDKIFC 62 VKIGGAekas....FILLTGPNMGGKSTLLRQVCLAVILAQ..IGADVPA.ETF.EVSPVDKICV 63 TILHAEgey.....CQIITGPNMGGKSCYIRQVALISIMAQ..VGSFVPA.SFA.KLHVLDGVFT 64 VDFKKEecn.....MFIITGPNMGGKSTYIRSVGTAVLMAH..IGAFVPC.SLA.TISMVDSILG 65 CTLVRGksw.....FQIITGPNMGGKSTFIRQVGVNVLMAQ..VGSFVPC.DQA.SISVRDCIFA 66 IELGKEqpr.....LGLLTGANAAGKSTILRMACIAVIMAQ..MGCYVPC.ESA.VLTPIDRIMT 67 IMMSPEngk.....INIITGPNMGGKSSYIRQVALLTIMAQ..IGSFVPA.EEI.RLSIFENVLT 68 IELGKEqpr.....LGLLTGANAAGKSTILRMACIAVIMAQ..MGCYVPC.ESA.VLTPIDRIMT 69 VTLTREdss.....FLIITGPNMGGKSTYIRQIGVIALMAQ..IGCFVPC.SSA.ELTIFDSILA 70 CELAKDn.......LWVITGPNMGGKSTFLRQNAIIVILAQ..IGCFVPC.SKA.RVGIVDKLFS 71 CFVGNGnvn.....IWLITGPNMAGKSTFLRQNAIISILAQ..IGSFVPA.SNA.RIGIVDQIFS 72 IMMSPEngk.....INIITGPNMGGKSSYIRQVALLTIMAQ..IGSFVPA.EEI.RLSIFENVLT 73 CELAKDn.......LWVITGPNMGGKSTFLRQNAIIVILAQ..IGCFVPC.SKA.RVGIVDKLFS 74 VNLEHGsse.....LLIITGPNMGGKSTYIRQVGVITVMAQ..IGCPVPC.EVA.DLDIIDAILA 75 TTMGASeaa.....VMLLTGPNMGGKSTLMRQTAVLAILAH..IGSMVPA.FSM.RLTPIDRIFT 76 VTLESGkgd.....FLIITGPNMGGKSTYIRQVGVISLMAQ..IGCFVPC.EEA.EIAIVDAILC 77 VTLESGkgd.....FLIITGPNMGGKSTYIRQVGVISLMAQ..IGCFVPC.EEA.EIAIVDAILC 78 LTLGQDlsglnrf.ALLLTGPNMGGKSTIMRATCLAVVLAQ..LGCYVPC.TSC.ELTLADSIFT 79 LTLGQDlsglnrf.ALLLTGPNMGGKSTIMRATCLAVVLAQ..LGCYVPC.TSC.ELTLADSIFT 80 TILHAEgey.....CQIITGPNMGGKSCYIRQVALISIMAQ..VGSFVPA.SFA.KLHVLDGVFT 81 TILHAEgey.....CQIITGPNMGGKSCYIRQVALISIMAQ..VGSFVPA.SFA.KLHVLDGVFT 82 ILLGEArrs10hprSLLLTGPNMGGKSTLLRATCLAVIFAQ..LGCYVPC.ESC.EISLVDTIFT 83 TECGGDkgr.....VKVITGPNSSGKSIYLKQVGLITFMAL..VGSFVPA.EEA.EIGAVDAIFT 84 TECGGDkgr.....VKVITGPNSSGKSIYLKQVGLITFMAL..VGSFVPA.EEA.EIGAVDAIFT 85 TECGGDkgr.....VKVITGPNSSGKSIYLKQVGLITFMAL..VGSFVPA.EEA.EIGAVDAIFT 86 VVLDKCr.......LIILTGANMGGKSTYLRSAALSILLAQ..IGSFVPC.SSA.TISVVDGIFT 87 TSLSDSerg15wekLLHKTG------------LTLVTIMAQ..IGSYVPA.E-A.TIGIVDGIFT 88 CFVGNGnvn.....IWLITGPNMAGKSTFLRQNAIISILAQ..IGSFVPA.SNA.RIGIVDQIFS 89 VSSGRDgik.....ASIITGPNACGKSVYMKSIGIMVFLSH..IGSFVPA.RHA.KIGIVDRIVT 90 VSSGRDgik.....ASIITGPNACGKSVYMKSIGIMVFLSH..IGSFVPA.RHA.KIGIVDRIVT 91 TDCGGDqgr.....VKVITGPNSSGKSIYLKQVGLITFMAL..VGSFVPA.EEA.EIGVIDAIFT 92 TDCGGDqgr.....VKVITGPNSSGKSIYLKQVGLITFMAL..VGSFVPA.EEA.EIGVIDAIFT 93 TYVTEGsn......FLIITGPNMSGKSTYLKQIALCQIMAQ..IGSYVPA.EYS.SFRIAKQIFT 94 TYVTEGsn......FLIITGPNMSGKSTYLKQIALCQIMAQ..IGSYVPA.EYS.SFRIAKQIFT 95 VSSGRDgik.....ASIITGPNACGKSVYMKSIGIMVFLSH..IGSFVPA.RHA.KIGIVDRIVT 96 VKIGGPgnas....FIVLTGPNMGGKSTLLRQVCLTIILAQ..IGADVPA.EKL.ELSLVDRIFV 97 LGLDNStr......MLIITGPNMGGKSTYMRQTALIVLLAH..IGSFVPA.ASC.ELSLVDRIFT 98 ISSTKHsss.....LQIITGCNMSGKSVYLKQVALICIMAQ..MGSGIPA.LYG.SFPVFKRLHA 99 ISSTKHsss.....LQIITGCNMSGKSVYLKQVALICIMAQ..MGSGIPA.LYG.SFPVFKRLHA 100 TCLTRDrr......FGIITGPNMAGKSTYLKQTAQLAIMAQ..IGCFIPA.NYA.SLPIFNRIFS 101 YSCNHElsr.....IHVITGANMSGKSVYLRQIAYLVIMAQ..MGCFVPA.EYA.RMRIFNSLYS 102 ISLEDK........GMLVFSVNGAGKSTLLRAIGVNVILAQ..AGMYVAA.DSF.KLRPYNYLIT 103 TMIDGGlfs14kgrIIVVTGANASGKSVYLTQNGLIVYLAQ..IGCFVPA.ERA.RIGIADKILT 104 TMIDGGlfs14kgrIIVVTGANASGKSVYLTQNGLIVYLAQ..IGCFVPA.ERA.RIGIADKILT 105 ISLEDK........GMLVFSVNGAGKSTLLRAIGVNVILAQ..AGMYVAA.DSF.KLRPYNYLIT 106 ------........---------------------------..-------.---.---------- 107 LELGTAseap....LSLLTGPNMGGKSTLMREVGLLVIMAQ..I------.---.---------- 108 IELGRDfs......TIVITGPNTGGKTVTLKTLGLLTLMAQ..SGLHIPAdEGS.EAAVFEHVFA 109 ILLKEKk.......GLILTGPNTGGKTVALKTLGLSVLMFQ..SAIPVPAsPNS.KLPLFEKVFT 110 CRLDNEtf......IYLITGPNMSGKSTYMRQVAIISIMAQ..MGAYVPC.KEA.VLPIFDQIFT 111 LELPPNkr......GFIITGPNMGGKTVTVKTVGLFTALMM..SGFPLPCdEGT.ELKVFPKIMA 112 VNLEHGsse.....LLIITGPNMGGKSTYIRQVGVITVMAQ..IGCPVPC.EVA.DLDIIDAILA 113 ------........---------------------------..-------.---.---------- 114 LTIDSQir......VIAITGPNTGGKTVTLKTLGLVALMAK..VGLYIPAkETV.EMPWFAQILA 115 IQLGETk.......LLLITGPNMGGKTATLKTLGLAVLMHQ..CGLYVAA.ASA.RLPVVRDILV 116 LKFEKS........MLAVTGVNAGGKTMLLKSLLSAAFLSKhlIPMKINA.HHS.IIPYFKEIHA 117 LKFEKS........MLAVTGVNAGGKTMLLKSLLSAAFLSKhlIPMKINA.HHS.TIPYFREIHA 118 CDLSPPngeqgga.IWLLTGPNMGGKSTFLRQNALIAIMAQ..TGSFVPA.AAA.HIGVVDRLFS 119 IEFMEDie......TVIITGPNTGGKTVTLKTLGLIIVMAQ..SGLLIPTlDGS.QLSVFKNVYC 120 ------........---------------------------..-------.---.---------- 121 FTPAENr.......VVIITGPNAGGKTVTLKTIGLLSAMFQ..FGIPIVVgESS.TFKIFDNIFI 122 ------........---------------------------..-------.---.---------- 123 IKVESSak......VVVISGPNTGGKTALLKTLGLLSLMSK..SGMYLPA.KNCpRLPWFDLILA 124 LEFKKQ........VLIITGVNAGGKSMLLKSMLSAAFLAKhlLPMHIKA.SES.KIGTFKEFDA 125 LEFKKQ........VLIITGVNAGGKSMLLKSMLSAAFLAKhlLPMHIKA.SES.KIGTFKEFDA 126 ------........---------------------------..-------.---.---------- 127 ------........---------------------------..-------.---.---------- 128 FQISKGtr......VLVITGPNTGGKTICLKSVGLAAMMAK..SGLYVLAtESA.RIPWFDNIYA 129 TDCGGDqgr.....VKVITGPNSSGKSIYLKQVGLITFMAL..VGSFVPA.EEA.EIGVIDAIFT 130 TECGGDkgr.....VKVITGPNSSGKSIYLKQVGLITFMAL..VGSFVPA.EEA.EIGAVDAIFT 131 ------........---------------------------..-------.---.---------- 132 ------........---------------------------..--SFVPA.AQC.ELSLVDRIFT 133 YFVGSAkgq11essVVILTGANSGGKTSLLELMLQIVILAH..MGLPVPA.SEA.WVEPLDEVFF 134 YFVGKArep11gsrVVILTGANSGGKTSLLELMLQIVVLAH..MGLPVPA.ENA.WVDVLNEVFF 135 ------........----TGPNMGGKSTFIRQVGVIVLMAQ..VGSFVPC.DKA.SISIRDCIFA 136 ------........----TGPNMGGKSTYMRQTALIVLLAH..IGSFVPA.AQC.ELSLVDRIFT 137 ----R-r.......MLIITGPNMGGKSTYMRQTALIALMAY..IGSYVPA.QKV.EIGPIDRIFT 138 ----R-r.......MLIITGPNMGGKSTYMRQTALIALMAY..IGSYVPA.QKV.EIGPIDRIFT 139 YRIGDPdn......VVLLTGANSGGKTTLLETLAQVTIMAQ..MGLPVCA.LEA.CVRVVDEVYF 140 CFVGNGnvn.....IWLITGPNMAGKSTFLRQNAIISILAQ..IGSFVPA.SNA.RIGIVDQIFS 141 ------........---------AGKSTYIRQIALLVIMAQ..MGSFIPA.KAA.HIGIVDKIFT 142 ------........---------AGKSTYIRQIALLVIMAQ..MGSFIPA.RSA.HIGIVDKIFT 143 ------........---------AGKSTYIRQIALLVIMAQ..MGSFIPA.RSA.HIGIIDKIFT 144 ------........---------AGKSTYIRQVALIAIMAQ..IGSYVPA.HSA.RIGIIDKVFS 145 ------........---------AGKSTYIRQIALLVIMAQ..MGSFIPA.KSA.HIGMIDKIFT 146 ------........---------AGKSTYIRQIALLVIMAQ..MGSFIPA.KSA.HIVMIDKIFT 147 ------........---------AGKSTYIRQIALLIIMAQ..MGSFIPA.RSA.HIGMIDKIFT 148 ------........---------------------------..-------.---.---------- 149 ------........------PNMGGKSTIMRATCLAIVLAQ..LGCYVPC.QSC.ELTLADAIFT 150 ------........----TGPNMGGKSTLLRATCLAVIFAQ..LGCYVPC.ESC.EISLVDTIFT 151 ------........---------------------------..-------.---.---------- 630 640 650 660 670 | | | | | 1 RIGASD.DLAGGKSTFMVEMEEVALI........LKEATEN........SLVLLDEVGRGTSSLD 2 RIGASD.DLAGGKSTFMVEMEEVALI........LKEATEN........SLVLLDEVGRGTSSLD 3 RIGASD.DLAGGKSTFMVEMEEVALV........LKEATER........SLVLLDEVGRGTSSLD 4 RIGASD.DLAGGKSTFMVEMEEVALV........LKEATER........SLVLLDEVGRGTSSLD 5 RIGASD.DLAGGKSTFMVEMEEVALV........LKEATER........SLVLLDEVGRGTSSLD 6 RIGASD.DLAGGKSTFMVEMEEVALV........LKEATER........SLVLLDEVGRGTSSLD 7 RVGAAD.DLASGRSTFMVEMTETANI........LHNATEY........SLVLMDEIGRGTSTYD 8 RVGAAD.DLASGRSTFMVEMTETANI........LHNATEY........SLVLMDEIGRGTSTYD 9 RIGSSD.DLAGGRSTFMVEMSETANI........LHNASER........SLVLMDEVGRGTSTFD 10 RVGAAD.DLASGRSTFMVEMTETANI........LHNATEY........SLVLMDEIGRGTSTYD 11 RIGASD.DLASGRSTFMVEMTEMANI........LHQATAQ........SLVLIDEIGRGTSTYD 12 RIGSSD.DLAGGRSTFMVEMSETANI........LHNATDK........SLVLMDEVGRGTSTFD 13 RIGSSDxDLAGGRSTFMVEMSETANI........LHNATDK........SLVLMDEVGRGTSTFD 14 RVGAGD.SQLKGVSTFMAEMLETASI........LRSATKD........SLIIIDELGRGTSTYD 15 RVGAAD.DLASGRSTFMVEMTETANI........LHNATEN........SLVLMDEIGRGTSTYD 16 RVGAGD.SQLKGVSTFMAEMLETSSI........LRSATKD........SLIIIDELGRGTSTYD 17 RVGAGD.SQLKGVSTFMAEMLETASI........LRSATKD........SLIIIDELGRGTSTYD 18 RVGAGD.SQLKGVSTFMAEMLETASI........LRSATKD........SLIIIDELGRGTSTYD 19 RLGASD.RIMSGESTFFVELSETASI........LRHATAH........SLVLVDELGRGTATFD 20 RVGAAD.DLASGRSTFMVEMTETANI........LHNATEN........SLVLMDEIGRGTSTYD 21 RLGASD.RIMSGESTFFVELSETASI........LRHATAH........SLVLVDELGRGTATFD 22 RLGASD.RIMSGESTFFVELSETASI........LMHATAH........SLVLVDELGRGTATFD 23 RLGASD.RIMSGESTFFVELSETASI........LMHATAH........SLVLVDELGRGTATFD 24 RLGASD.RIMSGESTFFVELSETASI........LMHATAH........SLVLVDELGRGTATFD 25 RLGASD.RIMSGESTFFVELSETASI........LMHATAH........SLVLVDELGRGTATFD 26 RVGAGD.SQLKGVSTFMAEMLETASI........LRSATKD........SLIIIDELGRGTSTYD 27 RVGAGD.SQLKGVSTFMAEMLETASI........LRSATEN........SLIIIDELGRGTSTYD 28 RIGAAD.DLVSGQSTFMVEMMEANNA........ISHATKN........SLILFDELGRGTATYD 29 RVGAVD.DLATGQSTFMVEMNETANI........LNHATAK........SLVLLDEIGRGTATFD 30 RIGAAD.DLISGQSTFMVEMLEAKNA........IVNATKN........SLILFDEIGRGTSTYD 31 RVGAVD.DLATGQSTFMVEMNETANI........LNHATAK........SLVLLDEIGRGTATFD 32 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEVGRGTSTYD 33 RIGASD.DLASNRSTFMVEMSETAYI........LHHATEQ........SLVLMDEVGRGTSTFD 34 RIGAAD.DLISGQSTFMVEMLEAKNA........IVNATKN........SLILFDEIGRGTSTYD 35 RMGAAD.NIYKGRSTFMEQLTDTAEI........IRRASPQ........SLVILDELGRGTSTHD 36 RMGAAD.NIYKGRSTFMEELTDTAEI........IRKATSQ........SLVILDELGRGTSTHD 37 RIGAAD.DLIKGQSTFMAEMLETSAI........LAQSTKN........SLIILDEVGRGTSTYD 38 RMGAAD.NIYKGRSTFMEQLTDTAEI........IRRASPQ........SLVILDELGRGTSTHD 39 RIGAGD.DLARGQSTFMLEMTETSYI........LHHATAQ........SLVLMDEIGRGTSTYD 40 RMGAAD.NIYKGRSTFMEQLTDTAEI........IRRASPQ........SLVILDELGRGTSTHD 41 RMGAAD.NIYKGRSTFMEELTDTAEI........IRKATSQ........SLVILDELGRGTSTHD 42 RIGASD.DLASNRSTFMVEMSETAYI........LHHATEQ........SLVLMDEVGRGTSTFD 43 RMGARD.DLAGGRSTFLVEMNEMALI........LLKSTNK........SLVLLDEVGRGTSTQD 44 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEIGRGTSTYD 45 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEVGRGTSTYD 46 RVGASD.DLARGRSTFMVEMVETAAI........LNQATDR........SLVILDEIGRGTATFD 47 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEVGRGTSTYD 48 RIGSGD.VLALGVSTFMNEMLDVSNI........LNNATKR........SLIILDEVGRGTSTYD 49 RMGARD.DLAGGRSTFLVEMNEMALI........LLKSTNK........SLVLLDEVGRGTSTQD 50 RVGAAD.NLARGESTFLVEMSETAHI........LRAATRD........SLVIMDEVGRGTATED 51 RVGASD.NIIKGLSTFMVEMIETSGI........IRTATDK........SLVIIDELGRGTSTYE 52 RMGSSD.NLSVNMSTFMVEMLETKEV........LSKATEK........SMVIIDELGRGTSTID 53 RIGSGD.VLALGVSTFMNEMLEVSNI........LNNATEK........SLVILDEVGRGTSTYD 54 RMGSSD.NLSVNMSTFMVEMLETKEV........LSKATEK........SMVIIDELGRGTSTID 55 RVGAGD.SQLKGVSTFMAEMLETASI........LRSATKD........SLIIIDELGRGTSTYD 56 RLGAND.DIMSARSTFMVELSETKKI........LDECGPK........SLVILDELGRGTSTYD 57 RMGAKD.HIMAGQSTFLTELSETAVM........LTSATRN........SLVVLDELGRGTATSD 58 RVGAGD.CQLRGVSTFMQEMLETASI........LKGASDK........SLIIIDELGRGTSTYD 59 RVGAGD.CQLRGVSTFMQEMLETASI........LKGATDK........SLIIIDELGRGTSTYD 60 RVGASD.NIIKGLSTFMVEMIETSGIirv24cgiLQTATDK........SLVIIDELGRGTSTYE 61 RIGASD.NIAKGESTFLVEMNETANI........LRNATEK........SLIIMDEVGRGTSTND 62 RMGAKD.HIMAGQSTFLTELSETAVM........LTSATRN........SLVVLDELGRGTATSD 63 RMGASD.SIQHGRSTFLEELSEASHI........IRTCSSR........SLVILDELGRGTSTHD 64 RVGASD.NIIKGLSTFMVEMIETSGI........IRTATDK........SLVIIDELGRGTSTYE 65 RVGAGD.CQLHGVSTFMQEMLETASI........LKGASDK........SLIIIDELGRGTSTYD 66 RLGAND.NIMQGKSTFFVELAETKKI........LDMATNR........SLLVVDELGRGGSSSD 67 RIGAHD.DIINGDSTFKVEMLDILHI........LKNCNKR........SLLLLDEVGRGTGTHD 68 RLGAND.NIMQGKSTFFVELAETKKI........LDMATNR........SLLVVDELGRGGSSSD 69 RVGASD.SQLKGVSTFMAEMLETANI........LKSATAE........SLIIIDELGRGTSTYD 70 RVGSAD.DLYNEMSTFMVEMIETSFI........LQGATER........SLAILDEIGRGTSGKE 71 RIGSAD.NLYQQKSTFMVEMMETSFI........LKNATRR........SFVIMDEIGRGTTASD 72 RIGAHD.DIINGDSTFKVEMLDILHI........LKNCNKR........SLLLLDEVGRGTGTHD 73 RVGSAD.DLYNEMSTFMVEMIETSFI........LQGATER........SLAILDEIGRGTSGKE 74 RVGASD.SQLKGISTFMAEMLETATI........LRAATPR........SLIIIDELGRGTSTTD 75 RIGAND.RIMCGESTFFIELKETDIM........LKNATKH........SLLLVDELGRGTSTFD 76 RVGAGD.SQLKGVSTFMVEILETASI........LKNASKN........SLIIVDELGRGTSTYD 77 RVGAGD.SQLKGVSTFMVEILETASI........LKNASKN........SLIIVDELGRGTSTYD 78 RLGATD.RIMTGESTFLVECTETASV........LQKATVD........SLVLLDELGRGTSTFD 79 RLGATD.RIMTGESTFLVECTETASV........LQKATVD........SLVLLDELGRGTSTFD 80 RMGASD.SIQHGRSTFLEE-------........-------........----LDELGRGTSTHD 81 RMGASD.SIQHGRSTFLEELN-----........-------........------ELGRGTSTHD 82 RLGASD.RIMTGESTFLVECTETASV........LQNATQD........SLVILDELGRGTSTFD 83 RIHSCE.SISLGLSTFMIDLNQVAKA........VNNATAQ........SLVLIDEFGKGTNTVD 84 RIHSCE.SISLGLSTFMIDLNQVAKA........VNNATAQ........SLVLIDEFGKGTNTVD 85 RIHSCE.SISLGLSTFMIDLNQVAKA........VNNATAQ........SLVLIDEFGKGTNTVD 86 RVGASD.KQSQGISTFMAEMLDCSAI........LQRATKN........SFVVIDELGRGTSTFD 87 RMGAAD.NIYKGRSTFMEQLTDTAEI........IQ-----........---------------- 88 RIGSAD.NLYQQKSTFMVEMMETSFI........LKNATRR........SFVIMDEIGRGTTASD 89 RMFTVD.SVLDGMSTFAKDVEQVALA........LRKATGN........SLVIIDEFGKGTMTEV 90 RMFTVD.SVLDGMSTFAKDVEQVALA........LRKATGN........SLVIIDEFGKGTMTEV 91 RIHSCE.SISLGLSTFMIDLNQVAKA........VNNATEH........SLVLIDEFGKGTNSVD 92 RIHSCE.SISLGLSTFMIDLNQVAKA........VNNATEH........SLVLIDEFGKGTNSVD 93 RISTDD.DIETNSSTFMKEMKEIAYI........LHNANDK........SLILIDELGRGTNTEE 94 RISTDD.DIETNSSTFMKEMKEIAYI........LHNANDK........SLILIDELGRGTNTEE 95 RMFTVD.SVLDGMSTFAKDVEQVALA........LRKATGN........SLVIIDEFGKGTMTEV 96 RMGARD.HIMAGQSTFLVELEETASV........LSSATKN........SLVVLDELGRGTSTSD 97 RIGSSD.DLAGGRSTFMVEMSETANI........LHNATDR........SLVLMDEMGRGTSTFD 98 RVC-ND.SMELTSSNFGFEMKEMAYF........LDDINTE........TLLILDELGRGSSIAD 99 RVC-ND.SMELTSSNFGFEMKEMAYF........LDDINTE........TLLILDELGRGSSIAD 100 RMGHND.ELIRNKSAFASEMSDAAAI........VQYADKN........SLVVLDELARSTSTEE 101 RIS-SD.NVDINASSFSKEMSETAVI........LNDSDGD........SLILIDELGRGSSLTD 102 RILGGD.DLYRGQGTFEVEMRDLSTI........LQLANYN........SLILGDEICHGTEVNS 103 RIRTQE.TVYKTQSSFLLDSQQMAKS........LSLATEK........SLILIDEYGKGTDILD 104 RIRTQE.TVYKTQSSFLLDSQQMAKS........LSLATEK........SLILIDEYGKGTDILD 105 RILGGD.DLYRGQGTFEVEMRDLSTI........LQLANYN........SLILGDEICHGTEVNS 106 ------.-------------------........-------........---------------- 107 ------.-------------------........-------........---------------- 108 DIGDEQ.SIEQSLSTFSSHMVNIVGI........LEQVNEN........SLVLFDELGAGTDPQE 109 DIGDEQ.SIEQNLSTFSAHVKNMAEF........LPKSDEN........TLVLIDELGAGTDPIE 110 RIGAAD.DLVSGKSTFMVEMLEAQKA........LTYATED........SLIIFDEIGRGTSTYD 111 DIGEEQ.SIEQSLSTFSSHMKKIVEI........VKNADSD........SLVILDELGSGTDPVE 112 RVGASD.SQLKGISTFMAEMLETATI........LRAATPR........SLIIIDELGRGTSTTD 113 ------.-------------------........-------........---------------- 114 DIGDEQ.SLQQNLSTFSGHICRIIRI........LQALPSGvqd18ifpSLVLLDEVGAGTDPTE 115 DIGDEQ.SIEASLSTFASHLKHLRYV........LRHAAPD........TLVLVDELGSGTDPDE 116 IINDPQ.NSANNISTFAGRMKQFSAL........L--SKEN........MLLGVDEIELGTDADE 117 IINDPQ.NSANNISTFAGRMKQFSAL........L--SKEN........MLLGVDEIELGTDADE 118 RVGASD.DLARGRSTFMVEMVETAAI........LNQATDR........SLVILDEIGRGTATFD 119 DIGDEQ.SIEQSLSTFSSHMTNIVEI........LKNADKH........SLVLFDELGAGTDPSE 120 ------.-------------------........-------........---------------- 121 DIGDEQ.SISNSLSTFSSHMSNISYI........LKHTTKD........SLVIFDEFCSGTDIDQ 122 ------.-------------------........-------........---------------- 123 DIGDPQ.SLEQSLSTFSGHISRIRQI........LDIASEN........SLVLLDEICSGTDPSE 124 IIEDPQ.NVKNDISTFAGRMLHFSRL........F--SKKN........LLLGIDEIELGTDFEE 125 IIEDPQ.NVKNDISTFAGRMLHFSRL........F--SKKN........LLLGIDEIELGTDFEE 126 ------.-------------------........-------........---------------- 127 ------.-------------------........-------........---------------- 128 DIGDEQ.SLLQSLSTFSGHLKQISEI........LSHSTSR........SLVLLDEVGAGTNPLE 129 RIHSCE.SISLGLSTFMIDLNQVAKA........VNNATEH........SLVLIDEFGKGTNSVD 130 RIHSCE.SISLGLSTFMIDLNQVAKA........VNNATAQ........SLVLIDEFGKGTNTVD 131 ------.-------------------........-------........---------------- 132 RIGSSD.DLAGGRSTFMVEMSETANI........LHNATDR........SLVLMDEVGRGTSTFD 133 --FKRK.RINYGAGAFESSLKSIVKA........LK-GKGR........KLILIDEFEAITEPGA 134 --FKKK.RSSYGAGAFEGSLKGIVRS........LR-GKGK........KLILIDEFEAITEPGA 135 RVGAGD.CQLRGVSTFMQEMLETASI........LKGATDK........SLIIIDELGRGTSTYD 136 RIGSSD.DLAGGRSTFMVEMSETANI........LHNATDR........SLVLMDEVGRGTSTFD 137 RVGAAD.DLASGRSTFMVEMTETANI........LHNATEY........SLVLMDEIGRGTSTYD 138 RVGAAD.DLASGRSTFMVEMTETANI........LHNATEY........SLVLMDEIGRGTSTYD 139 I---SK.KRSLDAGAFES-FIRTFTP........VTTSENS........KLILLDELEAITELEA 140 RIG---.-------------------........-------........---------------- 141 RIGAGD.NLAKGMSTFMVEMTETANI........LHNATNR........SLVILDEIGRGTSTYD 142 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEIGRGTSTYD 143 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEIGRGTSTYD 144 RIGASD.DLARGQSTFMVEMTETANI........LNNASPR........SLVILDEIGRGTSTYD 145 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEVGRGTSTYD 146 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLVILDEVGRGTSTYD 147 RIGAGD.NLSKGMSTFMVEMAETANI........LHNATDR........SLIVLDEVGRGTSTYD 148 ------.-------------------........-------........---------------- 149 RIGAMD.RIMSGESTFLVECTETASI........LENATED........SLVLLDELGSGTTTYD 150 RLGASD.RIMTGESTFLVECTETASV........LQNATQD........SLVILDELGRG----- 151 ------.-------------------........-------........---------------- 680 690 700 710 | | | | 1 GVAIATAVAEALHE....RRAYTLFATHYFELTAL........GLPRLKNLHVAARE........ 2 GVAIATAVAEALHE....RRAYTLFATHYFELTAL........GLPRLKNLHVAARE........ 3 GVAIATALAEALHE....RRCYTLFATHYFELTAL........ALPRLKNLHVAAKE........ 4 GVAIATALAEALHE....RRCYTLFATHYFELTAL........ALPRLKNLHVAAKE........ 5 GVAIATALAEALHE....RRCYTLFATHYFELTAL........ALPRLKNLHVAAKE........ 6 GVAIATALAEALHE....RRCYTLFATHYFELTAL........ALPRLKNLHVAAKE........ 7 GLSLAWACAENLANk...IKALTLFATHYFELTQLpe......KMEGVANVHLDALE........ 8 GLSLAWACAENLANk...IKALTLFATHYFELTQLpe......KMEGVANVHLDALE........ 9 GLSLAWAAAEHLAG....LRAWTLFATHYFELTVLae......SQPVVANVHLSATE........ 10 GLSLAWACAENLANk...IKALTLFATHYFELTQLpe......KMEGVANVHLDALE........ 11 GLSLAWACAEWLSKk...IRSLTLFATHYFELTALpe......QLEGIANIHLDALE........ 12 GLSLAWAAAEDLAR....TRAFTLFATHYFELTVLpe......SQPAVANVHLNATE........ 13 GLSLAWAAAEDLAR....TRAFTLFATHYFELTVLpe......SQPAVANVHLNATE........ 14 GFGLAWAISDYIATk...IGAFCMFATHFHELTALan......QIPTVNNLHVTALT........ 15 GLSLAWACAENLANk...IKALTLFATHYFELTQLpe......KMEGVANVHLDALE........ 16 GFGLAWAISDYIATk...IGAFCMFATHFHELTALan......QIPTVNNLHVTALT........ 17 GFGLAWAISEYIATk...IGAFCMFATHFHELTALan......QIPTVNNLHVTALT........ 18 GFGLAWAISEYIATk...IGAFCMFATHFHELTALan......QIPTVNNLHVTALT........ 19 GTAIANAVVKELAEt...IKCRTLFSTHYHSLVEDys......KSVCVRLGHMACMV........ 20 GLSLAWACAENLANk...IKALTLFATHYFELTQLpe......KMEGVANVHLDALE........ 21 GTAIASAVVKELAEt...IKCRTLFSTHYHSLVEDys......KSVCVRLGHMACMV........ 22 GTAIANAVVKELAEt...IKCRTLFSTHYHSLVEDys......QNVAVRLGHMACMV........ 23 GTAIANAVVKELAEt...IKCRTLFSTHYHSLVEDys......QNVAVRLGHMACMV........ 24 GTAIANAVVKELAEt...IKCRTLFSTHYHSLVEDys......QNVAVRLGHMACMV........ 25 GTAIANAVVKELAEt...IKCRTLFSTHYHSLVEDys......QNVAVRLGHMACMV........ 26 GFGLAWAISEYIATn...IGAFCMFATHFHELTALas......QIPTVNNLHVTALT........ 27 GFGLAWAISEYISTk...IKAFCMFATHFHELTALad......QVPTVNNLHVTALT........ 28 GMALAQSIIEYIHEh...IGAKTLFATHYHELTSLes......SLQHLVNVHVATLE........ 29 GLAIAWSVAEYLAGe...IQARTIFATHYHELNELas......LLENVANFQVTVKE........ 30 GMALAQAIIEYVHDh...IGAKTLFSTHYHELTVLed......KLPQLKNVHVRAEE........ 31 GLAIAWSVAEYLAGe...IQARTIFATHYHELNELas......LLENVANFQVTVKE........ 32 GLAIAQAVVEFLLFteg.KKAKTLFATHYKELTELel......HCQHVENFHAVVKE........ 33 GLALAHAVAEHLLQk...NKSFSLFATHYFELTYLpe......AHAAAVNMHLSALE........ 34 GMALAQAIIEYVHDh...IGAKTLFSTHYHELTVLed......KLPQLKNVHVRAEE........ 35 GIAIAYATLEYFIRd...VKSLTLFVTHYPPVCELekc.....YPEQVGNYHMGFLV........ 36 GIAIAYATLEYFIRd...VKSLTLFVTHYPPVCELekn.....YSHQVGNYHMGFLV........ 37 GVSIAWSVLEYIHDk...LQCRCLFATHYHELTVMkn......FLPALQNYTIAIEE........ 38 GIAIAYATLEYFIRd...VKSLTLFVTHYPPVCELekc.....YPEQVGNYHMGFLV........ 39 GLALADAVARHLAHi...NRCYTLFATHYFELTALadetyeg.GLSGIANVHFDAVE........ 40 GIAIAYATLEYFIRd...VKSLTLFVTHYPPVCELekc.....YPEQVGNYHMGFLV........ 41 GIAIAYATLEYFIRd...VKSLTLFVTHYPPVCELekn.....YSHQVGNYHMGFLV........ 42 GLALAHAVAEHLLQk...NKSFSLFATHYFELTYLpe......AHTAAVNMHLSALE........ 43 GVSIAWAISEELIK....RGCKVLFATHFTELTELek......HFPQVQNKTILVKE........ 44 GLAIAQAVVEFLLFtdg.KKAKTLFATHYKELTELem......HCQHVENFHAMVKE........ 45 GLAIAQAVVEYLLFtdk.KKAKTLFATHYKELTTLed......HCPHVENFHAGVKD........ 46 GLSIAWAAVEHLHEv...NRCRGLFATHFHELTVLse......KLVRLSNATMRVKE........ 47 GLAIAQAVVEYLLFtdk.KKAKTLFATHYKELTTLed......HCPHVENFHAGVKD........ 48 GIAISKAIVKYISEk...IGAKTLLATHYLELTELer......KVKGVKNYHMEVEE........ 49 GVSIAWAISEELIK....RGCKVLFATHFTELTELek......HFPQVQNKTILVKE........ 50 GLSIAQAVSEYLLHh...VRAKTLFATHYHELSRL........AHPQLEHLKLDVLE........ 51 GCGIAWSIAEHLAKe...TKCFTLFATHFHEITKLae......TLSTVKNCHMAAVA........ 52 GEAISYAVLHYLNQy...IKSYLLFVTHFPSLGILerr.....FEGQLRCFHMGYLK........ 53 GIAISKAIVKYISEk...LKAKTLLATHFLEITELeg......KIEGVKNYHMEVEK........ 54 GEAISYAVLHYLNQy...IKSYLLFVTHFPSLGILerr.....FEGQLRCFHMGYLK........ 55 GFGLAWAISEYIATk...IGAFCMFATIFMNL---........--------------........ 56 GHAIAYAVLHHLVSn...IGCLGFFSTHYQSLCVDfm......HHRQVRLMQMAAAV........ 57 GQAIAESVLEHFIEk...VQCRGFFSTHYHRLSVDyq......TNPKVSLCHMACQI........ 58 GFGLAWAICEHLVQv...KRAPTLFATHFHELTALaqa9evsgNTVGVANFHVSAHI........ 59 GFGLAWAICEHLVQv...KRAPTLFATHFHELTALaqa9evsgNTVGVANFHVSAHI........ 60 GCGIAWSIAEHLAKe...TKCFTLFATHFHEITKLae......TLSTVKNCHMAAVA........ 61 GLAIAYSIIEYILEy...IKARSLFATHFHELSSI........NHQAFINLSMKIEK........ 62 GQAIAESVLEHFIEk...VQCRGFFSTHYHRLSVDyq......TNPKVSLCHMACQI........ 63 GVAIAYATLQHLLAe...KRCLVLFVTHYPEIAEIsng.....FPGSVGTYHVSYLTlqkdkgsy 64 GCGIAWSIAEHLAKe...TKCFTLFATHFHEITKLae......TLSTVKNCHMAAVA........ 65 GFGLAWAICEHLMEv...TRAPTLFATHFHELTALahr11qhiSDIGVANYHVGAHI........ 66 GFAIAESVLHHVATh...IQSLGFFATHYGTLASSfk......HHPQVRPLKMSILV........ 67 GIAISYALIKYFSEls..DCPLILFTTHFPMLGEI........KSPLIRNYHMDYVE........ 68 GFAIAESVLHHVATh...IQSLGFFATHYGTLASSfk......HHPQVRPLKMSILV........ 69 GFGLAWAISEHIVKe...IGCFALFATHFHELTALad......QYPNVKNLHVTAHI........ 70 GISIAYATLKYLLEn...NQCRTLFATHFGQELKQiid9cskgMSEKVKFYQSGITD........ 71 GIAIAYGCLKYLSTi...NHSRTLFATHAHQLTNLtksf....KNVECYCTNLSIDR........ 72 GIAISYALIKYFSEls..DCPLILFTTHFPMLGEI........KSPLIRNYHMDYVE........ 73 GISIAYATLKYLLEn...NQCRTLFATHFGQELKQiid9cskgMSEKVKFYQSGITD........ 74 GFGLAWAITEHIVTq...IGCFCLFATHYHEMTKLse......EITTVKNLHVTAYV........ 75 GTAIASAVLQKISDd...LACRTFFSTHYHSICDSft......NHPNVRLAHMKCVV........ 76 GFGLAWAIAEHIASk...IGCFALFATHFHELTELse......KLPNVKNMHVVAHIekn9eqkh 77 GFGLAWAIAEHIASk...IGCFALFATHFHELTELse......KLPNVKNMHVVAHIekn9eqkh 78 GYAIAYAVFRHLVEr...VRCRQLFATHYHSLTKEfa......SHPHVSLQHMACMF........ 79 GYAIAYAVFRHLVEr...VRCRQLFATHYHSLTKEfa......SHPHVSLQHMACMF........ 80 GVAIAYATLQHLLAe...KRCLVLFVTHYPEIAEIsng.....FPGSVGTYHVSYLTlqkdkgsy 81 GVAIAYATLQHLLAe...KRCLVLFVTHYPEIAEIsng.....FPGSVGTYHVSYLTlqkdkgsy 82 GYAIAYSVFRHLVEk...VQCRMLFATHYHPLTKEfa......SHPRVTSKHMACAF........ 83 GLALLAAVLRHWLArgp.TCPHIFVATNFLSLVQLqllp....QGPLVQYLTMETCE........ 84 GLALLAAVLRHWLArgp.TCPHIFVATNFLSLVQLqllp....QGPLVQYLTMETCE........ 85 GLALLAAVLRHWLArgp.TCPTVFVATNFLSLVQLqllp....QGPLVQYLTMETCE........ 86 GFGIASAIAQDILNr...IQCLSIFATHFHEMGKLa.......EQPGAVALQMGVQI........ 87 --------------....-----------------........--------------........ 88 GIAIAYGCLKYLSTi...NHSRTLFATHAHQLTNLtksf....KNVECYCTNLSIDR........ 89 GLSLLASVMTYWMNrgadRCPHIFLSSHFHALPNYipl.....ETNIATFLTFTVLR........ 90 GLSLLASVMTYWMNrgadRCPHIFLSSHFHALPNYipl.....ETNIATFLTFTVLR........ 91 GLALLAAVLRHWLAlgp.SCPHVFVATNFLSLVQLqllp....QGPLVQYLTMETCE........ 92 GLALLAAVLRHWLAlgp.SCPHVFVATNFLSLVQLqllp....QGPLVQYLTMETCE........ 93 GIGICYAVCEYLLS....LKAFTLFATHFLELCHIda......LYPNVENMHFEVQH........ 94 GIGICYAVCEYLLS....LKAFTLFATHFLELCHIda......LYPNVENMHFEVQH........ 95 GLSLLASVMTYWMNrgadRCPHIFLSSHFHALPNYipl.....ETNIATFLTFTVLR........ 96 GQAIAASVLEYLVHq...VQCLGLFSTHYHRLAMEh.......NDTKVSLCHMACEV........ 97 GLSLAWAAAERLAQ....LRAYTLFATHYFELTVLpe......SEPLVANVHLNATE........ 98 GFCVSLAVTEHLLR....TEATVFLSTHFQDIPKIms......KKPAVSHLHMDAVL........ 99 GFCVSLAVTEHLLR....TEATVFLSTHFQDIPKIms......KKPAVSHLHMDAVL........ 100 GIAITYAICEKVLK....LQSYTFLATHFLDIAALan......YSNAIDNYHFLPQT........ 101 GFSICLAILEDLIC....KEATVITTTHFRDIAQVla......NKSCVVTAHMQTVE........ 102 GTAILAATIERLIN....AQTSFVLSTHLHQVCSL........IDSPVRYYHLSVIQ........ 103 GPSLFGSIMLNMSKse..KCPRIIACTHFHELFNEnvl21isqKYNLLETAHVGEDH........ 104 GPSLFGSIMLNMSKse..KCPRIIACTHFHELFNEnvl21isqKYNLLETAHVGEDH........ 105 GTAILAATIERLIN....AQTSFVLSTHLHQVCSL........IDSPVRYYHLSVIQ........ 106 --------------....-----------------........--------------........ 107 --------------....-----------------........--------------........ 108 GAALAMSILDDVHR....TNARVLATTHYPELKAY........GYNREGVMNASVEF........ 109 GSALGIGILEYLKK....KKAWVFVTTHHTPIKLY........STNSDYYTPASVLF........ 110 GLALAQAMIEYVAEt...SHAKTLFSTHYHELTTLdq......ALPSLKNVHVAANE........ 111 GAALAIAIIEDLLE....KGATIFVTTHLTPVKVF........AMNHPLLLNASMEF........ 112 GFGLAWAITEHIVTq...IGCFCLFATHYHEMTKLse......EITTVKNLHVTAYV........ 113 --------------....-----------------........--------------........ 114 GSALAIALLRHLAD....QPCLTVATTHYGELKAL........KYQDARFENASVEF........ 115 GAALAQSLIETLLE....QDARGIITSHLSPLKLF........ALETPGLKNASMGF........ 116 ASSLYKTLLEKLLK....QNNQIIITTHHKRLSVL........MAENKEVELLAALY........ 117 ASSLYKTLLEKLLK....QNNQIVITTHHKRLSVL........MAENKEVELLAALY........ 118 GLSIAWAAVEHLHEv...NRCRGLFATHFHELTVLse......KLVRLSNATMRVKE........ 119 GAALAMSILDHVRK....IGSLVMATTHYPELKAY........SYNREGVMNASVEF........ 120 --------------....-----------------........--------------........ 121 GQALAISILEYLIN....INSYVLISTHYNALKYF........AYTHEGVVNASMRM........ 122 --------------....-----------------........--------------........ 123 GVALATSILQYIKN....RVNVAVVSTHYGDLSRL........KDNEPRFQNAAMEF........ 124 AACLYSVLISKLIA....NNLKIIITTHHKRLAML........LAKNEQVELIAALY........ 125 AACLYSVLISKLIA....NNLKIIITTHHKRLAML........LAKNEQVELIAALY........ 126 --------------....-----------------........--------------........ 127 --------------....-----------------........--------------........ 128 GAALGMAILESFAEs...GSLLTMATTHHGELKTL........KYSNSAFENACMEF........ 129 GLALLAAVLRHWLAlgp.SCPHVFVATNFLSLVQLq.......--------------........ 130 GLALLAAVLRHWLArgp.TCPHIFVATNFLSLVQLqllp....QGPLV---------........ 131 --------------....-----------------........--------------........ 132 GLSLAWAAAERLAQ....LRAYTLFATHYFELTVLpe......SEPLVANVHLNATE........ 133 AAKILAELLKIGVE....KGFYIVIVSHLGEDLKKel......PYARVDGIEASGLD........ 134 AVKILAELLKVGIS....KGFYIVIVSHLGEDLMKel......PEARVDGIEASGLD........ 135 GFGLAWAICEHLVQv...KRAPTLFATHY------........--------------........ 136 GLSLAWAAAECLAQ....LRAYTLFATHY------........--------------........ 137 GLSLAWACAENLANk...IKALTLFATHYF-----........--------------........ 138 GLSLAWACAENLANk...IKALTLFATHY------........--------------........ 139 AVKIIATFIEFIGE....SSSLAVIVTHMAREIMKy.......VDVRVDGIEARGLD........ 140 --------------....-----------------........--------------........ 141 GLAIAQAVVEYLL-....-----------------........--------------........ 142 GLAIAQAVVEFLL-....-----------------........--------------........ 143 GLAIAQAVVEFLL-....-----------------........--------------........ 144 GISIAWAVAEHLL-....-----------------........--------------........ 145 GLAIAQSVVEYLL-....-----------------........--------------........ 146 GLAIAQSVVEYLL-....-----------------........--------------........ 147 GLAIAQSVVEYLL-....-----------------........--------------........ 148 --------------....-----------------........--------------........ 149 G-------------....-----------------........--------------........ 150 --------------....-----------------........--------------........ 151 --------------....-----------------........--------------........ 720 730 740 750 760 | | | | | 1 EAGG........LVFYHQVLPGPAS.KSYGVEVAAMAG.LPKEVVAR.ARALLQAM..AA..... 2 EAGG........LVFYHQVLPGPAS.KSYGVEVAAMAG.LPKEVVAR.ARALLQAM..AA..... 3 EEGG........LVFYHQVLPGPAS.KSYGVEVAEMAG.LPKEVVER.ARALLSAM..AA..... 4 EEGG........LVFYHQVLPGPAS.KSYGVEVAEMAG.LPKEVVER.ARALLSAM..AA..... 5 EEGG........LVFYHQVLPGPAS.KSYGVEVAEMAG.LPKEVVER.ARALLSAM..AA..... 6 EEGG........LVFYHQVLPGPAS.KSYGVEVAEMAG.LPKEVVER.ARALLSAM..AA..... 7 HGDT........IAFMHSVQDGAAS.KSYGLAVAALAG.VPKEVIKR.ARQKLREL..ESisp18 8 HGDT........IAFMHSVQDGAAS.KSYGLAVAALAG.VPKEVIKR.ARQKLREL..ESisp18 9 HNER........IVFLHHVLPGPAS.QSYGLAVAQLAG.VPGPVISR.AREHLARL..EAtsl22 10 HGDT........IAFMHSVQDGAAS.KSYGLAVAALAG.VPKEVIKR.ARQKLREL..ESisp18 11 HNNT........IAFMHAVQNGAAS.KSYGLAVAALAG.VPQSVIKL.AKQKLTQL..EKnss23 12 HNER........IVFLHHVLPGPAS.QSYGLAVAQLAG.VPTPVIQR.AREHLKRL..ETtsl22 13 HNER........IVFLHHVLPGPAS.QSYGLAVAQLAG.VPAPVIQR.AREHLKRL..ETtsl22 14 TEET........LTMLYQVKKGVCD.QSFGIHVAELAN.FPRHVIAC.AKQKALEL..EE..... 15 HGDT........IAFMHSVQDGAAS.KSYGLAVAALAG.VPKEVIKR.ARQKLREL..ESisp18 16 TEET........LTMLYQVKKGVCD.QSFGIHVAELAN.FPRHVIAC.AKQKALEL..EE..... 17 TEET........LTMLYQVKKGVCD.QSFGIHVAELAN.FPKHVIEC.AKQKALEL..EE..... 18 TEET........LTMLYQVKKGVCD.QSFGIHVAELAN.FPKHVIEC.AKQKALEL..EE..... 19 ENECedpsqet.ITFLYKFIKGACP.KSYGFNAARLAN.LPEEVIQK.GHRKAREF..ER..... 20 HGDT........IAFMHSVQDGAAS.KSYGLAVAALAG.VPKEVIKR.ARQKLREL..ESisp18 21 ENECedpsqet.ITFLYKFIKGACP.KSYGFNAARLAN.LPEEVIQK.GHRKAREF..ER..... 22 ENECedpsqet.ITFLYKFIKGACP.KSYGFNAARLAN.LPEEVIQK.GHRKAREF..EK..... 23 ENECedpsqet.ITFLYKFIKGACP.KSYGFNAARLAN.LPEEVIQK.GHRKAREF..EK..... 24 ENECedpsqet.ITFLYKFIKGACP.KSYGFNAARLAN.LPEEVIQK.GHRKAREF..EK..... 25 ENECedpsqet.ITFLYKFIKGACP.KSYGFNAARLAN.LPEEVIQK.GHRKAREF..EK..... 26 TEET........LTMLYQVKTGVCD.QSFGIHVAELAN.FPRHVIEC.AKQKALEL..EE..... 27 TEDTl.......ITMLYRIKKGVCD.QSFGIHVAELAN.FPKHVIET.AKEKALEL..EE..... 28 QDGQ........VTFLHKIEPGPAD.KSYGIHVAKIAG.LPADLLAR.ADKILTQL..EN..... 29 LPEE........IIFLHQVTPGGAD.KSYGIEAGRLAG.LPSSVITR.ARQVMAQI..EK..... 30 YNGT........VVFLHQIKEGAAD.KSYGIHVAQLAE.LPGDLIAR.AQDILKEL..EH..... 31 LPEE........IIFLHQVTPGGAD.KSYGIEAGRLAG.LPSSVITR.ARQVMAQI..EK..... 32 NGGQ........PVFMYEIAKGHSK.KSFGIHVAKLAG.FPLSVVSR.AQQILHQF..EG..... 33 QGQD........IVFLHQIQPGPAG.KSYGIAVAKLAG.LPVRALKS.AQKHLNGL..ENqaa32 34 YNGT........VVFLHQIKEGAAD.KSYGIHVAQLAE.LPGDLIAR.AQDILKEL..EH..... 35 NEDEskq14pdsVTFLYQITRGIAA.RSYGLNVAKLAD.VPREVLQK.AAHKSKEL..EG..... 36 SEDEskl14pdfVTFLYQITRGIAA.RSYGLNVAKLAD.VPGEILKK.AAHKSKEL..EG..... 37 SGKD........ILFLHNIILGASN.KSYGLHVAALAG.LPTSVINR.AAQILLKF..EKisi24 38 NEDEskq14pdsVTFLYQITRGIAA.RSYGLNVAKLAD.VPREVLQK.AAHKSKEL..EG..... 39 HSER........LVFMHTVKDGPAN.RSFGLQVAALAG.LPAAAVAH.ARRRLAEL..EQrgr22 40 NEDEskq14pdsVTFLYQITRGIAA.RSYGLNVAKLAD.VPREVLQK.AAHKSKEL..EG..... 41 SEDEskl14pdfVTFLYQITRGIAA.RSYGLNVAKLAD.VPGEILKK.AAHKSKEL..EG..... 42 QGQD........IVFLHQIQPGPAG.KSYGIAVAKLAG.LPVRALKS.AQKHLNGL..ENqaa32 43 EGKN........VIFTHKVVDGVAD.RSYGIEVAKIAG.IPDRVINR.AYEILE--..--..... 44 NSGQ........PIFMYEIVKGHSK.KSFGIHVAKLAG.FPLSVVSR.AQQILHQF..EG..... 45 KAGQ........PVFLYEILKGHSQ.KSFGIHVARLAG.FPLCVVSR.AQQILRQL..EG..... 46 WDGD........VIFLHEVGPGAAD.RSYGIQVARLAG.LPASVVAR.ARDVLAKL..EDadr27 47 KAGQ........PVFLYEILKGHSQ.KSFGIHVARLAG.FPLCVVSR.AQQILRQL..EG..... 48 TDEG........IRFLYILKEGRAK.GSFGIDVAKLAG.LPEEVVRE.AKKILKEL..EG..... 49 EGKN........VIFTHKVVDGVAD.RSYGIEVAKIAG.IPDRVINR.AYEILE--..--..... 50 TDNT........IVFLKKVTPGSCG.SSYGIYVARLAG.LPESVLAR.ACELLKQL..QQ..... 51 DADD........FTLLYQVRPGVME.KSFGIQVARLAN.FPEHVVQN.AQEVYNEF..ED..... 52 SKEDfetsvsqsISFLYKLVPGVAS.KSYGLNVARMAG.IPFSILSR.ATEISENY..EK..... 53 TPEG........IRFLYILKEGKAE.GSFGIEVAKLAG.LPEEVVEE.ARKILREL..EE..... 54 SKEDfetsvsqsISFLYKLVPGVAS.KSYGLNVARMAG.IPFSILSR.ATEISE--..--..... 55 ----........-------------.------------.--------.--------..--..... 56 DEKIrr......VTFLYKLEDGICP.KSYGMNVASMAG.LPEKVIDA.AEEKASEL..EQ..... 57 GEGIggvee...VTFLYRLTPGACP.KSYGVNVARLAG.LPDYVLQR.AVIKSQEF..EA..... 58 DTESrk......LTMLYKVEPGACD.QSFGIHVAEFAN.FPESVVAL.AREKAAEL..ED..... 59 DTESrk......LTMLYKVEPGACD.QSFGIHVAEFAN.FPESVVAL.AREKAAEL..ED..... 60 DADD........FTLLYQVRSGVME.KSFGIQVARLAN.FPEHVVQN.AQEVYNEF..ED..... 61 QGND........LVFLREVEEKPSL.NSYGIYVARIAG.LPLRVIDR.ANVILESL..VG..... 62 GEGIggvee...VTFLYRLTPGACP.KSYGVNVARLAG.LPDYVLQR.AVIKSQEF..EA..... 63 DHDD........VTYLYKLVRGLCS.RSFGFKVAQLAQ.IPPSCIRR.AISMAAKL..EA..... 64 DADD........FTLLYQVRSGVME.KSFGIQVARLAN.FPEHVVQN.AQEVYNEF..ED..... 65 DPLSrk......LTMLYKVEPGACD.QSFGIHVAEFAN.FPEAVVAL.AKSKAAEL..ED..... 66 DEATrn......VTFLYKMLEGQSE.GSFGMHVASMCG.ISKEIIDN.AQIAADNL..EH..... 67 EQKTgedwms..VIFLYKLKKGLTY.NSYGMNVAKLAR.LDKDIINR.AFSISEEL..RK..... 68 DEATrn......VTFLYKMLEGQSE.GSFGMHVASMCG.ISKEIIDN.AQIAADNL..EH..... 69 SGTDtdt18kreVTLLYKVEPGICD.QSFGIHVAELVR.FPDKVVRM.AKRKADEL..ED..... 70 LGGNn.......FCYNHKLKPGICT.KSDAIRVAELAG.FPMEALKE.AREI----..--..... 71 DDHT........FSFDYKLKKGVNY.QSHGLKVAEMAG.IPKNVLLA.AEEVL---..--..... 72 EQKTgedwms..VIFLYKLKKGLTY.NSYGMNVAKLAR.LDKDIINR.AFSISEEL..RK..... 73 LGGNn.......FCYNHKLKPGICT.KSDAIRVAELAG.FPMEALKE.AREI----..--..... 74 GDSEskd.....VALLYNVCEGASD.RSFGIHVAKLAH.FPPKIIEM.ASNKAAEL..EA..... 75 DKENnedptmedVTFLYELESGICP.KSYGFYAAKLAG.IDHQVVRN.AYLESNKF..ASnl... 76 DDED........ITLLYKVEPGISD.QSFGIHVAEVVQ.FPEKIVKM.AKRKANEL..DD..... 77 DDED........ITLLYKVEPGISD.QSFGIHVAEVVQ.FPEKIVKM.AKRKANEL..DD..... 78 KPRSdgngqke.LTFLYRLTSGACP.ESYGLQVAAMAG.IPKSIVEK.ASVAGQVM..RA..... 79 KPRSdgngqke.LTFLYRLTSGACP.ESYGLQVAAMAG.IPKSIVEK.ASVAGQVM..RA..... 80 DHDD........VTYLYKLVRGLCS.RSFGFKVAQLAQ.IPPSCIRR.AISMAAKL..EA..... 81 DHDD........VTYLYKLVRGLCS.RSFGFKVAQLAQ.IPPSCIRR.AISMAAKL..EA..... 82 KSRSdyq10dqdLVFLYRLTEGACP.ESYGLQVALMAG.IPNQVVET.ASGAAQAM..KR..... 83 DGND........LVFFYQVCEGVAK.ASHASHTAAQAG.LPDKLVAR.GKEVSDLI..RS..... 84 DGND........LVFFYQVCEGVAK.ASHASHTAAQAG.LLDKLVAR.GKEVSDLI..RS..... 85 DGND........LVFFYQVCEGVAK.ASHASHTAAQAG.LPDKLVAR.GKEVSDLI..RS..... 86 ENNE........IHMLYKVFEGVAQ.CSFGLQVAKMVG.IDENVINK.AAQLLEGL..EK..... 87 ----........-------------.------------.--------.--------..--..... 88 DDHT........FSFDYKLKKGVNY.QSHGLKVAEMAG.IPKNVLLA.AEEVL---..--..... 89 EAGGk.......IKYLFRMTPGLVD.CSFALSVAKEEG.IPPPVIGR.ACRIYKAL..KAg.... 90 EAGGk.......IKYLFRMTPGLVD.CSFALSVAKEEG.IPPPVIGR.ACRIYKAL..KAg.... 91 DGED........LVFFYQLCQGVAS.ASHASHTAAQAG.LPDPLIAR.GKEVSDLI..RS..... 92 DGED........LVFFYQLCQGVAS.ASHASHTAAQAG.LPDPLIAR.GKEVSDLI..RS..... 93 VKNTsrnkea..ILYTYKLSKGLTEeKNYGLKAAEVSS.LPPSIVLD.AKEITTQI..TR..... 94 VKNTsrnkea..ILYTYKLSKGLTEeKNYGLKAAEVSS.LPPSIVLD.AKEITTQI..TR..... 95 EAGGk.......IKYLFRMTPGLVD.CSFALSVAKEEG.IPPPVIGR.ACRIYKAL..KAg.... 96 VEGGgglee...VTFLYRLTPGACP.KSYGVNVARLAG.IPTKLLQR.ANEKSSEF..EA..... 97 HNER........IVFLHHVLPGPAS.QSYGLAVAQLAG.VPTAVIQR.AREHLGRL..ETtsl24 98 LNDNs.......VKMNYQLTQKSVAiENSGIRVVKKI-.FNPDIIAE.AYNMDS--..--..... 99 LNDNs.......VKMNYQLTQKSVAiENSGIRVVKKI-.FNPDIIAE.AYNIHSLL..--..... 100 DENS........-TKKHKLLRGQYRgPLYGFELVELST.IPDEVIEH.AQSLATEL..RA..... 101 TNGQ........LEMKYNLVLGRNDiVGYGIRFAEVSNlLPQELIED.SKVVANIL..RS..... 102 QENSa.......LIYERKLKPGPGP.SQYGIEV-----.--------.--------..--..... 103 ESEG........ITFLFKVKEGISK.QSFGIYCAKVCG.LSPDIVER.AEELSR-M..IN..... 104 ESEG........ITFLFKVKEGISK.QSFGIYCAKVCG.LSRDIVER.AEELSR-M..IN..... 105 QENSa.......LIYERKLKPGPGP.SQYGIEV-----.--------.--------..--..... 106 ----........-------------.------------.--------.--------..--..... 107 ----........-------------.------------.--------.--------..--..... 108 DIET........LSPTYKLLIGVPG.RSNAFEISKRLG.LPDHIIGQ.AKSEMTAE..HN..... 109 DRET........LKPLYKIAYNTVG.ESMAFYIAQKYG.IPSEVIEI.AKRHVGEF..GE..... 110 YKGE........LIFLHKVKDGAVD.DSYGIQVAKLAD.LPEKVISR.AQVILSEF..EAsag15 111 DPET........LSPTYRVLVGVPG.GSHAFQIAEKLG.LDKRIIEN.ARSRLSRE..EM..... 112 GDSEskd.....VALLYNVCEGASD.RSFGIHVAKLAH.FPPKIIEM.ASNKAAEL..EA..... 113 ----........-------------.------------.--------.--------..--..... 114 DDQS........LSPTYRLLWGIPG.RSNALAIAQRLG.LPLAIVEQ.AKDKLGGF..SE..... 115 AVGT........LAPTYQLQVGQPG.RSYALAIANRMG.LPRDVLSR.AEELLGPE..AG..... 116 DEEK........ERPTYTFLKGVIG.KSYAFETALRYG.VPHFLIEK.AKTFYGED..KE..... 117 DEEK........ERPTYTFLKGVIG.KSYAFETALRYG.VPPFLIEK.AKAFYGED..KE..... 118 WDGD........VIFLHEVGPGAAD.RSYGIQVARLAG.LPASVVAR.ARDVLAKL..EDadr27 119 DVDT........LSPTYKLLMGVPG.RSNAFDISKKLG.LSLNIINK.AKTMIGTD..EK..... 120 ----........-------------.------------.--------.--------..--..... 121 DLET........MQPNYNLIFSIPG.ESYAFNVASKAL.IDRSIVIR.ANEIYSSQ..KT..... 122 ----........-------------.------------.--------.--------..--..... 123 SMET........LQPTFRVLWGSTG.LSNALRVAKSIG.FNKRILEN.AHKWTEKLnpEQ..... 124 DEEL........SRPKYEFLKGTIG.KSYAFETALRYQ.IPPNLVSE.AKKLYGED..KE..... 125 DEEL........SRPKYEFLKGTIG.KSYAFETALRYQ.IPPNLVSE.AKKLYGED..KG..... 126 ----........-------------.------------.--------.--------..--..... 127 ----........-------------.------------.--------.--------..--..... 128 DDLN........LKPTYKILWGVPG.RSNAINIADRLG.LPCDIIES.ARELYGSA..SA..... 129 ----........-------------.------------.--------.--------..--..... 130 ----........-------------.------------.--------.--------..--..... 131 ----........-------------.------------.--------.--------..--..... 132 HNER........IVFLHHVLPGPAS.QSYGLAVAQLAG.VPTAVIQR.AREHLGRL..ETasl24 133 EELN........LIVDRQPKFGVIG.KS----------.TPELILER.LARKGRGE..ER..... 134 ENLN........LIVDRQPKFGIIG.RS----------.TPELILERlARKGRGEE..RD..... 135 ----........-------------.------------.--------.--------..--..... 136 ----........-------------.------------.--------.--------..--..... 137 ----........-------------.------------.--------.--------..--..... 138 ----........-------------.------------.--------.--------..--..... 139 DDYN........LIVDRTPRINYLA.RS----------.TPELIIRM.IYEKSSDD..ER..... 140 ----........-------------.------------.--------.--------..--..... 141 ----........-------------.------------.--------.--------..--..... 142 ----........-------------.------------.--------.--------..--..... 143 ----........-------------.------------.--------.--------..--..... 144 ----........-------------.------------.--------.--------..--..... 145 ----........-------------.------------.--------.--------..--..... 146 ----........-------------.------------.--------.--------..--..... 147 ----........-------------.------------.--------.--------..--..... 148 ----........-------------.------------.--------.--------..--..... 149 ----........-------------.------------.--------.--------..--..... 150 ----........-------------.------------.--------.--------..--..... 151 ----........-------------.------------.--------.--------..--..... 770 780 790 800 810 | | | | | 1 ...R..RE..GALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG 2 ...R..RE..GALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMK- 3 ...R..RE..GALEEVLERLLALDPDRLTPLEALRFLHELKALALGLPLGSMK- 4 ...R..RE..GALEEVLERLLALNPDRLTPLEALRFLHELKALALGLPLGSMK- 5 ...R..RE..GALEEVLERLLALNPDRLTPLEALRFLHELKALALGLPLGSMK- 6 ...R..RE..GALEEVLERLLALDPDRLTPLEALRFLHELKALALGLPLGSMK- 7 sllS..VP..EETSPAVEALENLDPDSLTPRQALEWIYRLK------------- 8 sllS..VP..EETSPAVEALENLDPDSLTPRQALEWIYRLK------------- 9 qsdL..FA..SLPHPLMEELARLKPDDLSPRQALELLYSW-------------- 10 sllS..VP..EETSPAVEALENLDPDSLTPRQALEWIYRLK------------- 11 gelF..FE..QETDALREAIEKLDPDDLSPKQALAYLYQLKK------------ 12 qsdL..FA..SLPHPVIDELSRINPDDISPRQALDLLYA--------------- 13 qsdL..FA..SLPHPVIDELSRINPDDISPRQALDLLYA--------------- 14 ...F..QNi.GTSLGCDEAEPAAKRRCLEREQGEKIILEFLSKVKQVPFTAM-- 15 sllA..AP..EETSPAVEALENLDPDSLTPRQALEWIYRLK------------- 16 ...F..QNi.GTSLGCDEAEPAAKRRCLEREQGEKIILEFLSKVKQVPFTAM-- 17 ...Fq.YI..GESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPFTEM-- 18 ...F..QY..-------------------------------------------- 19 ...-..MN..QSLQLFREVCLATEKPTINGEAIHR------------------- 20 sllA..AP..EETSPAVEALENLDPDSLTPRQALEWIYRLK------------- 21 ...-..MN..QSLRLFRGVCLATEKPTINGEAIHR------------------- 22 ...-..MN..QSLRLFREVCLASERSTVDAEAVHKLL----------------- 23 ...-..MN..QSLRLFREVCLASERSTVDAEAVHKLL----------------- 24 ...-..MN..QSLRLFREVCLASERSTVDAEAVHKLL----------------- 25 ...-..MN..QSLRLFREVCLASERSTVDAEAVHKLL----------------- 26 ...Fq.SI..GTSQGHDETQPAAKRRCLEREQGEKIILEFLSKVKQVPFT---- 27 ...F..QY..VGNPDDCDDEPARKRRCEEKEEGEKIIQDFLSRVKALPLTEM-- 28 ...Q..GT..ESPPP--------------------------------------- 29 ...H..--..-------------------------------------------- 30 ...S..GN..KPEVPVQKPQVKEEPAQLSFFDEAEKPAE--------------- 31 ...H..--..-------------------------------------------- 32 ...-..--..-------------------------------------------- 33 dkaE..EK..HFEGILAAALEKLDPDSLTPREALSELYRLKDLC---------- 34 ...S..GN..KPEVPVQKPQVKEEPAQLSFFDEAEKPAE--------------- 35 ...L..V-..-------------------------------------------- 36 ...L..IN..TK------------------------------------------ 37 fehE..KP..ISNSKLDEEFKTIDPDKISPKEALELIYKFK------------- 38 ...L..V-..-------------------------------------------- 39 qcsL..FA..SAPSAAQEALVALHPDELTPKQALEALYRLK------------- 40 ...L..V-..-------------------------------------------- 41 ...L..IN..TK------------------------------------------ 42 dkaE..EK..HFEGILAAALEKLDPDSLTPREALSELYRLKDLC---------- 43 ...-..--..-------------------------------------------- 44 ...-..--..-------------------------------------------- 45 ...-..--..-------------------------------------------- 46 eaaR..AS..SGPSKVEEALKALNPDDMTPREALDALYALK------------- 47 ...-..--..-------------------------------------------- 48 ...Ek.GK..QEVLPFLEETYKKSVDEEKLNFYEEIIKEIE------------- 49 ...-..--..-------------------------------------------- 50 ...R..AG..S------------------------------------------- 51 ...E..HV..DKQKKEDKAL---------------------------------- 52 ...K..HR..NAR----------------------------------------- 53 ...K..ENkkEDIVPLLEETFKKSEEAQRLEEYEEIIKKIEE------------ 54 ...-..--..-------------------------------------------- 55 ...-..--..-------------------------------------------- 56 ...A..SA..SFINASDDI--ALMSDF--------------------------- 57 ...L..YG..KNHRKTDH------------------------------------ 58 ...F..SP..SSMIINNEESGKRKSREDDPDEVSRGAERAHKFLKEF------- 59 ...F..SP..SSMIINNEESGKRKSREDDPDEVSRGAERAHKFLKEF------- 60 ...E..HV..DKQKKEDKAL---------------------------------- 61 ...R..EG..NSCLEFLPHVSSDGNDKEILKNDTDIHIKLNE------------ 62 ...L..YG..KNHRKTDH------------------------------------ 63 ...E..VR..ARERNTRMGEPEGHEEPRGAEESISALGDLF------------- 64 ...E..HV..DKQKKEDKAL---------------------------------- 65 ...FstTP..TFSDDLKDEVGSKRKRVFSPDDITRGAARARLFLEEFA------ 66 ...-..--..-------------------------------------------- 67 ...EsiNE..DALKLFSSLKRILKSDNITATDKLA------------------- 68 ...-..--..-------------------------------------------- 69 ...F..TS..KHEEEN-------------------------------------- 70 ...-..--..-------------------------------------------- 71 ...-..--..-------------------------------------------- 72 ...EsiNE..DALKLFSSLKRILKSDNITATDKLA------------------- 73 ...-..--..-------------------------------------------- 74 ...E..DS..GAQGDTQEVKSKKE------------------------------ 75 ...I..ID..PKIRHLVECARDDNFDVGEL------------------------ 76 ...-..--..-----LKTNNEDLKKAKLSLQEVNEGNIRLKALLKEWIRKVK-- 77 ...-..--..-----LKTNNEDLKKAKLSLQEVNEGNIRLKALLKEWIRKVK-- 78 ...K..IA..GNFKS--------------------------------------- 79 ...K..IA..GNFKS--------------------------------------- 80 ...E..VR..ARERNTRMGEPEGHEEPRGAEESISALGDLF------------- 81 ...E..VR..ARERNTRMGEPEGHEEPRGAEESISALGDLF------------- 82 ...S..IG..ENFK---------------------------------------- 83 ...-..--..-------------------------------------------- 84 ...-..--..-------------------------------------------- 85 ...-..--..-------------------------------------------- 86 ...K..LV..IDSKKKKEL----------------------------------- 87 ...-..--..-------------------------------------------- 88 ...-..--..-------------------------------------------- 89 ...-..--..-------------------------------------------- 90 ...-..--..-------------------------------------------- 91 ...-..--..-------------------------------------------- 92 ...-..--..-------------------------------------------- 93 ...Q..IL..QNQRSTPEME---------------------------------- 94 ...Q..IL..QNQRSTPEME---------------------------------- 95 ...-..--..-------------------------------------------- 96 ...N..YG..KRHKMTNDKHVSAQ------------------------------ 97 qsdL..FA..SLPHPAIEKLGKLQLDDMTPRQAIEMLYQLK------------- 98 ...-..--..-------------------------------------------- 99 ...-..--..-------------------------------------------- 100 ...N..VE..DTERDYDSERRRIK------------------------------ 101 ...R..KP..VHGDKELKLLSRRRKLVLELYFALNYI----------------- 102 ...-..--..-------------------------------------------- 103 ...R..GD..DVVQQCGNLTEKEMREFQKNQEIVKKFLS--------------- 104 ...R..GD..DVVQQCGNLTEKEMREFQKNQEIVKKFLS--------------- 105 ...-..--..-------------------------------------------- 106 ...-..--..-------------------------------------------- 107 ...-..--..-------------------------------------------- 108 ...E..VD..TMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQI------ 109 ...Q..YI..KAMEKLSDYVKKYEEEFRKLEELRKELQKEKEEVEKLRKE---- 110 mveN..EP..EINQE--------------------------------------- 111 ...E..LE..GLIRSLHEKISLLEEEKRKLQKEREEYMKLREKYE--------- 112 ...E..DS..GAQGDTQEVKSKKE------------------------------ 113 ...-..--..-------------------------------------------- 114 ...D..IN..QVIAGLESQRREQEQKAANAQKLLQE------------------ 115 ...L..ME..RMLSELERERRELGEQLETAAAARR------------------- 116 ...K..LN..VLIENSSALERELKQKNEHLENALKEQEYLKNA----------- 117 ...K..LN..VLIENSSTLERELKQKNEHLENALKEQEDLKNAW---------- 118 eaaR..AS..SGPSKVEEALKALNPDDMTPREALDALYALK------------- 119 ...E..IN..EMIESLERNYKRVETQRLELDRLVKEAEQVHD------------ 120 ...-..--..-------------------------------------------- 121 ...E..IN..EILEKLIEKEKD-------------------------------- 122 ...-..--..-------------------------------------------- 123 ...D..VE..RKGSLFQSLMEERNKLKLQATKTAAFHRDLMNLYHELEHES--- 124 ...N..LE..ELVGKNINLELELKAKLENVEKKEQKVDEIL------------- 125 ...N..LE..ELVGKNINLELELKAKLENVEKKEQKVDEIL------------- 126 ...-..--..-------------------------------------------- 127 ...-..--..-------------------------------------------- 128 ...E..IN..EVILDMERYKQEYQRLLNESRVYIRLSRELHENLLTA------- 129 ...-..--..-------------------------------------------- 130 ...-..--..-------------------------------------------- 131 ...-..--..-------------------------------------------- 132 qsdL..FA..SLPHPAIEKLGKLDLDDMTPRQAIEMLYQLK------------- 133 ...E..--..-------------------------------------------- 134 ...-..--..-------------------------------------------- 135 ...-..--..-------------------------------------------- 136 ...-..--..-------------------------------------------- 137 ...-..--..-------------------------------------------- 138 ...-..--..-------------------------------------------- 139 ...I..VY..GRILEKFQKTD--------------------------------- 140 ...-..--..-------------------------------------------- 141 ...-..--..-------------------------------------------- 142 ...-..--..-------------------------------------------- 143 ...-..--..-------------------------------------------- 144 ...-..--..-------------------------------------------- 145 ...-..--..-------------------------------------------- 146 ...-..--..-------------------------------------------- 147 ...-..--..-------------------------------------------- 148 ...-..--..-------------------------------------------- 149 ...-..--..-------------------------------------------- 150 ...-..--..-------------------------------------------- 151 ...-..--..--------------------------------------------