; SAM: prettyalign v3.2 (July 31, 2000) compiled 08/11/00_16:27:51 ; (c) 1992-2000 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequences correspond to the following labels: ; 1 gi|6537164|gb|AAF15552.1|_49:215 ; 2 gi|7543733|gb|AAF63635.1|_49:215 ; 3 gi|2292917|emb|CAA68163.1|_49:215 ; 4 gi|2736186|gb|AAB94084.1|_49:215 ; 5 gi|3913721|sp|P56599|GAL1_CANMA_40:207 ; 6 gi|2494674|sp|P56091|GAL1_CANAL_41:223 ; 7 gi|6016092|sp|O42821|GAL1_CANPA_40:219 ; 8 gi|8894769|emb|CAB95929.1|_25:179 ; 9 gi|208230|gb|AAA72509.1|_21:180 ; 10 gi|120898|sp|P06976|GAL1_ECOLI_21:180 ; 11 gi|2501753|gb|AAC48872.1|_21:180 ; 12 gi|9656105|gb|AAF94749.1|_41:203 ; 13 gi|7434202|pir||F71144_3:176 ; 14 gi|2660644|emb|CAA04516.1|_1:127 ; 15 gi|6831547|sp|P56838|GAL1_THEMA_1:191 ; 16 gi|6831546|sp|O85253|GAL1_THENE_1:191 ; 17 gi|729557|sp|P39574|GAL1_BACSU_21:219 ; 18 gi|120900|sp|Q00052|GAL1_LACHE_22:219 ; 19 gi|8928118|sp|Q9ZB10|GALK_STRTR_21:219 ; 20 gi|2494673|sp|P96993|GAL1_STRMU_21:219 ; 21 gi|5733507|gb|AAD49612.1|_23:220 ; 22 gi|4995690|emb|CAB44216.1|_30:228 ; 23 gi|4206187|gb|AAD11510.1|_30:228 ; 24 gi|6707009|gb|AAF25548.1|AF109295_3_21:218 ; 25 gi|6225403|sp|O84902|GAL1_LACCA_21:218 ; 26 gi|7450508|pir||F72364_1:228 ; 27 gi|7521143|pir||E72511_33:280 ; 28 gi|7447991|pir||F75161_26:170 ; 29 gi|7447990|pir||E69207_28:169 ; 30 gi|2128859|pir||G64479_27:178 ; 31 gi|7447992|pir||H69314_4:151 ; 32 gi|7429727|pir||F71066_11:134 ; 33 gi|7445272|pir||B75078_11:116 ; 34 gi|7429728|pir||D71246_19:123 ; 35 gi|3183231|sp|O26918|Y830_METTH_18:144 ; 36 gi|3183451|sp|O28190|YK89_ARCFU_15:128 ; 37 gi|2909376|emb|CAA76303.1|_15:128 ; 38 gi|3183371|sp|Q58822|YE27_METJA_13:200 ; 39 gi|9937394|gb|AAG02446.1|AF290095_2_17:184 ; 40 gi|9937380|gb|AAG02436.1|AF290091_2_18:156 ; 41 gi|9937373|gb|AAG02431.1|AF290089_2_18:155 ; 42 gi|9937365|gb|AAG02425.1|AF290087_2_18:157 ; 43 gi|9695271|dbj|BAB07791.1|_35:172 ; 44 gi|7463680|pir||E70185_16:143 ; 45 gi|9937401|gb|AAG02451.1|AF290097_2_19:172 ; 46 gi|9937408|gb|AAG02456.1|AF290099_2_19:173 ; 47 gi|2497515|sp|Q58504|KHSE_METJA_3:296 ; 48 T0115-outer ; 49 gi|147980|gb|AAA83915.1|_3:241 ; 50 gi|266419|sp|P00547|KHSE_ECOLI_3:242 ; 51 gi|125395|sp|P27722|KHSE_SERMA_3:242 ; 52 gi|9656932|gb|AAF95506.1|_3:248 ; 53 gi|1170650|sp|P44504|KHSE_HAEIN_3:250 ; 54 gi|9107373|gb|AAF85023.1|AE004035_2_16:255 ; 55 gi|7532410|gb|AAF63224.1|_49:300 ; 56 gi|4927412|gb|AAD33097.1|AF082525_1_49:300 ; 57 gi|7434441|pir||H75080_4:234 ; 58 gi|7450512|pir||D71103_2:212 ; 59 gi|6967628|emb|CAB72618.1|_1:233 ; 60 gi|7450510|pir||C71940_3:230 ; 61 gi|7450509|pir||B64651_3:230 ; 62 gi|6225592|sp|O67332|KHSE_AQUAE_3:231 ; 63 gi|80285|pir||B25364_8:239 ; 64 gi|6648061|sp|P04948|KHSE_BACSU_8:240 ; 65 gi|1730045|sp|P52991|KHSE_LACLA_1:231 ; 66 gi|2497513|sp|P72535|KHSE_STRPN_1:225 ; 67 gi|1170651|sp|P45836|KHSE_MYCLE_14:179 ; 68 gi|1730046|sp|Q10603|KHSE_MYCTU_17:180 ; 69 gi|125391|sp|P08210|KHSE_CORGL_9:245 ; 70 gi|125390|sp|P07128|KHSE_BRELA_9:245 ; 71 gi|125393|sp|P04947|KHSE_FREDI_4:241 ; 72 gi|2497514|sp|P73646|KHSE_SYNY3_4:239 ; 73 gi|7472024|pir||G75280_7:240 ; 74 gi|2497516|sp|Q92209|KHSE_CANAL_5:142 ; 75 gi|6321814|ref|NP_011890.1|_5:290 ; 76 gi|4614|emb|CAA37083.1|_5:289 ; 77 gi|7490646|pir||T40495_4:271 ; 78 gi|6323864|ref|NP_013935.1|_8:219 ; 79 gi|2804172|dbj|BAA24409.1|_8:218 ; 80 gi|1170660|sp|P46086|KIME_ARATH_4:226 ; 81 gi|5578718|gb|AAD45421.1|L77688_1_4:224 ; 82 gi|8928161|sp|Q9Y946|KIME_AERPE_6:169 ; 83 gi|2497517|sp|Q58487|KIME_METJA_1:176 ; 84 gi|8928178|sp|O59291|KIME_PYRHO_6:186 ; 85 gi|8928195|sp|Q9V187|KIME_PYRAB_6:185 ; 86 gi|8928130|sp|O27995|KIME_ARCFU_1:151 ; 87 gi|9937372|gb|AAG02430.1|AF290089_1_5:177 ; 88 gi|9937364|gb|AAG02424.1|AF290087_1_6:177 ; 89 gi|9937379|gb|AAG02435.1|AF290091_1_6:176 ; 90 gi|9937393|gb|AAG02445.1|AF290095_1_6:162 ; 91 gi|9937386|gb|AAG02440.1|AF290093_1_8:165 ; 92 gi|9711346|dbj|BAB07817.1|_21:180 ; 93 gi|9695270|dbj|BAB07790.1|_31:204 ; 94 gi|9937388|gb|AAG02442.1|AF290093_3_4:203 ; 95 gi|9937395|gb|AAG02447.1|AF290095_3_4:203 ; 96 gi|9937381|gb|AAG02437.1|AF290091_3_3:206 ; 97 gi|629246|pir||S44963_26:168 ; 98 gi|6919912|sp|O83386|IPK_TREPA_8:173 ; 99 gi|6919911|sp|O67060|IPK_AQUAE_6:155 ; 100 gi|6899611|gb|AAF31014.1|AE002158_12_25:149 ; 101 gi|6919910|sp|O25984|IPK_HELPY_37:149 ; 102 gi|6968538|emb|CAB73359.1|_4:177 ; 103 gi|6919916|sp|Q9X1A3|IPK_THEMA_14:161 ; 104 gi|6919913|sp|O84810|IPK_CHLTR_5:154 ; 105 gi|7190224|gb|AAF39061.1|_5:151 ; 106 gi|8979328|dbj|BAA99162.1|_5:135 ; 107 gi|9107876|gb|AAF85442.1|AE004071_10_22:200 ; 108 gi|1175665|sp|P42805|IPK_PSEAE_9:186 ; 109 gi|9950924|gb|AAG08056.1|AE004880_12_9:186 ; 110 gi|549526|sp|P30753|IPK_SALTY_7:190 ; 111 gi|321817|pir||PC1178_3:131 ; 112 gi|140422|sp|P24209|IPK_ECOLI_7:190 ; 113 gi|9656736|gb|AAF95327.1|_15:192 ; 114 gi|1175664|sp|P45271|IPK_HAEIN_26:204 ; 115 gi|1074864|pir||A64173_34:212 ; 116 gi|586879|sp|P37550|IPK_BACSU_7:171 ; 117 gi|8894781|emb|CAB95941.1|_7:165 ; 118 gi|6919909|sp|O05596|IPK_MYCTU_10:160 ; 119 gi|6919915|sp|P72663|IPK_SYNY3_8:179 ; 120 gi|7471511|pir||E75254_14:166 ; 121 gi|7379787|emb|CAB84355.1|_12:189 ; 122 gi|7226111|gb|AAF41285.1|_12:189 10 20 30 40 | | | | 1 LFARSPGRVNLIGEHIDYE-GYSVL...PMAIR..-.....QDTIIAIRK..CEDQKQLria12t 2 LFARSPGRVNLIGEHIDYE-GYSVL...PMAIR..-.....QDTIIAIRK..CEDQKQLria12t 3 LFARSPGRVNLIGEHIDYE-GYSVL...PMAIR..-.....QDTIIAIRK..CEDQKQLria12t 4 LFARSPGRVNLIGEHIDYE-GYSVL...PMAIR..-.....QDTIIAIRK..CEDQKQLria12t 5 FFARSPGRVNLIGDHIDYN-FFPVL...PMAIA..-.....NDVIAAVNV..NSTNEIIitn11f 6 FFARSPGRVNLIGDHIDYN-FFPVL...PMAIS..-.....ADVIVAVNV..NDEPEIVith15t 7 FFARSPGRVNLIGDHIDYN-YFPVL...PMAIE..-.....VDVVAAVST..NNNDMIVian12p 8 --WAAPGRVNLIGEHTDYNDGF-VM...PFALP..-.....HQAVAAVSR..RDDGILRlhs10a 9 HTIQAPGRVNLIGEHTDYNDGF-VL...PCAID..-.....YQTVISCAP..RDDRKVRvma11q 10 HTIQAPGRVNLIGEHTDYNDGF-VL...PCAID..-.....YQTVISCAP..RDDRKVRvma11q 11 HTIQAPGRVNLIGEHTDYNDGF-VL...PCAID..-.....YQTVISCAP..RDDRKVRvma11q 12 HLVQAPGRVNLIGEHTDYNDGF-VL...PCAIN..-.....YQTVVAAAK..REDFLVRlva11d 13 -KVKSPGRVNLIGEHTDYTYGY-VM...PMAIN..-.....LYTKIEAEK..HGEVILY...... 14 MKVKAPGRINIIGEHTDYNDGY-VL...PFAVN..-.....RYVFLSIEG..SERFIFH...... 15 MKVKAPGRINIIGEHTDYNDGY-VL...PFAVN..-.....RYVFLSIEG..SERFIFH...... 16 MRVKAPGRINIIGEHTDYNDGY-VL...PFAVN..-.....RFVFLTIED..SGKFVFH...... 17 -FFFAPGRVNLIGEHTDYNGGH-VF...PCALT..-.....MGTYAAVAE..RNDGLVRmys11a 18 --FFSPGRINVIGEHTDYNGGH-VF...PAPIS..-.....LGVYGVYGP..RDDKKVRlys12i 19 -TFFSPGRINLIGEHTDYNGGN-VL...PVAIT..-.....LGTYGAARK..RDDKVLRffs11k 20 -TFFSPGRINLIGEHTDYNGGR-VF...PAAIT..-.....LGTYGAARK..RDDKLLRfys11l 21 --YFSPGRINLIGEHTDYNGGH-VF...PASIT..-.....YGTQGVAAS..RKDNKVLvys11d 22 -YFFSPGRINLIGEHTDYNGGY-VF...PASIT..-.....IGTTGLARL..REDNKVKlys11l 23 -YFFSPGRINLIGEHTDYNGGY-VF...PASIT..-.....IGTTGLARL..REDKKVKlys11l 24 --AFAPGRINLIGEHTDYNGGY-VF...PAAIE..-.....LGTYGLASK..RNDNKIClys11t 25 -TFFAPGRINLIGEHTDYNGGH-VF...PCAIS..-.....LGTYAAVGT..NEDNAFRlys10r 26 ------MKVLVPATTTNLGAGFDVF...GLALD..-.....LFNEVEFSF..DTKETTI...... 27 ---CSRARARAYSSAANLGPGFDAL...AVALD..A.....YYDEVEVRV..CSGGNSVyvdev. 28 -------------------------...----Gi.E.....LWTEARVRV..TGDGEVR...... 29 -------------------------...---FGi.G.....LRVEAEAEL..IDSGVEC...... 30 -------------------------...---L-..D.....LKVYAKVKL..IDDGKNK...... 31 --------AKAYAAGTVLNALPTGI...GSAFGi.E.....MHTIVKLRP..SDELKVF...... 32 -----RLHLGIIDPTGSLGRKFGSI...GVALE..-.....GGYDIKVTP..AGSLTIE...... 33 --------LGMIDPTGSLGRRFGSI...GVALE..-.....GGYEIKVTP..AGSLTIE...... 34 ---------------GDMGRLFGTL...GFAIE..Y.....PYLEVEIET..SEKDKA-...... 35 --------IDLNGERGRLDGGV---...GITLN..E.....PELVVGLEA..SDDMGVE...... 36 --------IDLNGSIGRVDGGV---...GLALE..E.....PHIEIKAKE..SETFVLK...... 37 --------IDLNAEIGRVDGGV---...GITLE..S.....PSLEISASE..ADTVEVV...... 38 -------LIDLNGSIGRVDGGI---...GLALE..E.....PNIKIEGKE..SDDISIEfdkkl. 39 YWGKKNEELILPMNN--------SL...SLTLD..A.....FYTETEVIF..SDSYMVD...... 40 YWGKADETYIIPMNN--------SL...SVTLD..R.....FYTETKVTF..DPDFTED...... 41 YWGKADEALIIPMNN--------SL...SVTLD..R.....FYTETRVTF..DETLTED...... 42 YWGKKDEALIIPMNN--------SI...SVTLE..K.....FYTETKVTF..NDQLTQD...... 43 YWGKRDERLILPCTT--------SL...SMTLD..V.....FPTTTEVRL..DPAAEHD...... 44 YWGKKDVFLNIPATS--------SL...AVSVD..K.....FYSISELEL..SNRDEII...... 45 YWGKENQAKMIPSTS--------SI...SLTLE..N.....MFTTTSVSF..LPDTATS...... 46 YWGKKKEKEMVPATS--------SI...SLTLE..N.....MYTETTLSP..LPANVTA...... 47 --EIMKVRVKAPCTSANLGVGFDVF...GLCLK..E.....PYDVIEVEA..IDDKEII...... 48 MREIMKVRVKAPCTSANLGVGFDVF...GLCLK..E.....PYDVIEVEA..IDDKEII...... 49 -------KVYAPASSANMSVGFDVL...GAAVT..PvdgalLGDVVTVEA..AQTFSLNn..... 50 -------KVYAPASSANMSVGFDVL...GAAVT..PvdgalLGDVVTVEA..AETFSLNn..... 51 -------KVYAPASIGNVSVGFDVL...GAAVS..PidgtlLGDCVSVEA..AETFSLQn..... 52 ------VVVYAPASIGNVSVGFDVL...GAAVS..PidgtlLGDRVKVEA..GAEAFTLkt.... 53 -------RIYAPASSANISVGFDTL...GAAIS..PidgslLGDVVQIES..ISTGFELes.... 54 -PAAHQARAFAPASVANVAVGFDLL...GYPMD..Q.....VGDTVTVRR..IDTPQVRiaa... 55 -PVFVSVKTFAPATVANLGPGFDFL...GCAVD..G.....LGDHVTLRV..DPSVRAGevsise 56 -PVFVSVKTFAPATVANLGPGFDFL...GCAVD..G.....LGDHVTLRV..DPSVRAGevsise 57 -------RIYAPATIANFGPGFDVF...GMAIE..E.....PGDEVIVKE..SDSFEIE...... 58 -------------------------...--AID..K.....PFDEVVVEE..FNEFEII...... 59 ------MKILVPATSANLGPGFDCL...GLSLK..-.....LFNETQIQK..SGVFSIS...... 60 --------VSVPATSANLGPGFDCL...GLSLN..-.....LRNRFFIEP..SNIHAVK...... 61 --------VSVPATSANLGPGFDCL...GLSLN..-.....LRNRFFIEP..SSFHAVK...... 62 -------KIEVPATTTNFGSGFDTF...GLALS..-.....LTNTFSVDF..SDKYEVQ...... 63 ------FSVTVPGSTANLGPGFDSV...GMALS..-.....RYLKLTVFE..SDKWSFE...... 64 ------FSVTVPGSTANLGPGFDSV...GMALS..-.....RYLKLTVFE..SDKWSFEa..... 65 ------MKIIVPATSANLGAGFDSI...GIAVN..-.....LYLTVEVLG..ESRDWKI...... 66 ------MKIIVPATSANIGPGFDSV...GVAVT..-.....KYLQIEVSE..ERDEWLI...... 67 ---------VVAASSANLGPGFDSI...GLALS..-.....LCDEIVVET..TDSGLVVvv.... 68 ----------VAASSANLGPGFDSV...GLALS..-.....LYDEIIVET..TDSGLTVtv.... 69 ----RKVTVTVPGSSANLGPGFDTL...GLALS..-.....VYDTVEVEI..IPSGLEVev.... 70 ----RKVTVTVPGSSANLGPGFDTL...GLALS..-.....VYDTVEVEI..IPSGLEVev.... 71 ---VSSVTVTVPATTANLGPGFDCI...GAALT..-.....LYNKVKFTR..LDAGGLIihv... 72 ------FTVSVPATTANIGPGFDCL...GAALG..-.....LYNHVTVTD..PTDPEVDlliea. 73 -----PFTVRAPASSANLGPGFDSL...GLSVP..-.....LYTTLRVTP..QDKAEVVp..... 74 -----SFKIKVPASSANIGPGFDVL...GIGLQ..-.....LYLTITVTI..DPSIDTSsdphha 75 ------FKIKVPASSANIGPGYDVL...GVGLS..-.....LFLELDVTI..DSSQAQEtnd14y 76 ------FKIKVPASSANIGPGYDVL...GVGLS..-.....LFLELDVTI..DSSQAQEtnd14y 77 ------FQIKVPASSANIGPGFDVL...GMSLE..-.....EYMTLDVEV..STESGPCvlty.. 78 ---SAPGKVIIFGEHSAVY-NKPAV...AASVS..A.....LRTYLLISE..SSAPDTIeld44s 79 ---SAPGKVIIFGEHSAVY-NKPAV...AASVS..A.....LRTYLLISE..SSAPDTIeld44s 80 -KARAPGKIILAGEHAVVH-GSTAV...AAAID..-.....LYTYVTLRF..PLPSAENndr48l 81 -KARAPGKIILAGEHAVVH-GSTAV...AAAID..-.....LYTYVTLRFpl-PSNNDRltl45l 82 -RASAPGKVIIVGEHFVVRGSL-AI...VAAIG..-.....RRLRVTVRS..GGKGIVL...... 83 MIIETPSKVILFGEHAVVY-GYRAI...SMAID..-.....LTSTIEIKE..TQEDEIIlnl15n 84 -LASAPAKVILFGEHSVVY-GKPAI...ASAIE..-.....LRTYVRAQF..NDSGNIKiea12g 85 -LASAPAKIILFGEHSVVY-GKPAI...ASAID..-.....LRTYVRAEF..NDSGNIKiea12g 86 MIASAPGKIILFGEHAVVY-GRHAV...VSAIN..-.....LRCRVSVRK..SDRFLIR...... 87 GYGESNGKIILIGEHAV-TFGEPAI...AIPFTsgK.....VKVLIESLE..KGNYSAI...... 88 -YGESTGKIILIGEHAV-TFGEPAI...AVPFNagK.....IKVLIEALE..SGNYSSI...... 89 -YGESTGKIILMGEHAV-TFGQPAI...AIPFN..A.....GKIKVLIES..LDEGNYSsi.... 90 -QGESSGKIILMGEHAVVY-GEPAI...AFPFY..A.....TKVTAFLEE..LDAMDDQl..... 91 -LGQATGKIILMGEHAVVY-GEPAI...AFPFQ..A.....TEITAVFTP..AKTMQIDcay... 92 -TGRAHAKAILLGEHAVVY-GTPAL...AMPIP..Q.....LAVTASAGW..SGRSAES...... 93 -IGRAHAKAILLGEHAVVY-GAPAL...ALPIP..Q.....LTVTASVGW..SSEASDS...... 94 --VTTPGKLFIAGEYAVVEPGHPAI...IVAVD..-.....QFVTVTVEE..TTDEGSI...... 95 --VSAPGKLYIAGEYAVVETGHPAV...IAAVD..-.....QFVTVTVES..ARKVGSI...... 96 -QVKAPGKLYIAGEYAVTEPGYKSI...LIAVN..-.....RFVTATIEA..SNKVEGSihskt. 97 -------------------HGCRLL...AVALT..A.....HGALRLAEA..PEGVTVR...... 98 AHAKVNMHLWVGARRAD---GLHSI...ESVMQ..R.....ITLADSLSL..SRLDIPG...... 99 SPAKINLGLWVLGRLPS---GYHEI...LTLYQ..E.....IPFYDEIYI..REGVLRV...... 100 -------------------HDFESI...FILVE..N.....IYDDIEITK..IEKNIDD...... 101 -------------------------...-----..K.....LKDIISVKS..ALSFS--...... 102 -YAKANIFLKLTGFDSRKYHLLESR...FILLK..D.....VFDELELVD..KESDSKK...... 103 SYAKLNLYLDVLGKRSD---GYHEI...VGLFQtiS.....LHDTLTVEI..CDRGFYL...... 104 SPAKLNLFLQILGRRED---DFHEI...VTRYQaiA.....FGDQLSLSI..SSRDSLQ...... 105 SPAKLNIFLQLLGKRED---GFHEI...VTRYQavS.....FGDQLSLSV..SSRDSFQ...... 106 SPAKLNLFLKIWGKRFD---NFHEL...TTLYQ..A.....IDFGDTLSL..KNSMKDS...... 107 APAKLNLFLQITGRRVD---GYHEL...QTVFRllD.....WGDTIHLRV..REDGQIH...... 108 APAKLNLFLHILGRRDD---GYHEL...QTLFQflD.....HGDELHFEA..RQDGQVR...... 109 APAKLNLFLHILGRRDD---GYHEL...QTLFQflD.....HGDELHFEA..RQDGQVR...... 110 SPAKLNLFLYITGQRAD---GYHTL...QTLFQflD.....YGDTLHIEP..RHDGEIH...... 111 -------------------------...-----..-.....---------..-------...... 112 SPAKLNLFLYITGQRAD---GYHTL...QTLFQflD.....YGDTISIEL..RDDGDIR...... 113 SPAKLNLFLYITGRRAN---GYHDL...QTLFQflD.....HGDELTITA..NNSGNIT...... 114 SPAKLNLFLYINGKFPN---GYHEL...QTLFQflD.....FGDWLDISI..REQDNQI...... 115 SPAKLNLFLYINGKFPN---GYHEL...QTLFQflD.....FGDWLDISI..REQDNQI...... 116 APAKINLSLDVTRKRPDGYHEVEMI...MTTID..-.....LADRIELTE..LAEDEVR...... 117 VPAKVNVQLAVGAARPD---GFHDLanvFLAVS..-.....LYDEVTATP..AADGLRVtc.... 118 VPGKVNLYLAVGDRRED---GYHEL...TTVFH..A.....VSLVDEVTV..RNADVLSlel... 119 APAKINLFLEILGDRPD---GFHEL...VMVLQsiA.....LGDKITVRA..NGTDDIR...... 120 APAKINLGLSVLGVRENGYHDLHSL...MVPLT..-.....VGDELEIRP..AGALTLR...... 121 APAKLNLDLRITGRREDGYHNIESI...FCLID..-.....LQDTVYLKP..RDDGKII...... 122 APAKLNLDLRITGRREDGYHNIESI...FCLID..-.....LQDTVYLKP..RDDGKII...... 50 60 70 80 90 | | | | | 1 mcTYPADPDQEIDLKN........HKWGHYFICAYKGF...HEYaks11gspVGLDVLVDGIVPT 2 mcTYPADPDQEIDLKN........HKWGHYFICAYKGF...HEYaks11gspVGLDVLVDGIVPT 3 mcTYPADPDQEIDLKN........HKWGHYFICAYKGF...HEYaks11gspVGLDVLVDGIVPT 4 mcTYPADPDQEIDLKN........HKWGHYFICAYKGF...HEYaks11gspVGLDVLVDGIVPT 5 lkEVIALRNSQIDQEH........HSWANYFKCALIVA...KQYlee9vtslKGMKLTFNGNVPT 6 ipLTNNNDGFEIDSQH........HSWANYFKCALIVA...NNYlte10gqlKGMKLTFDGNVPT 7 keTVSLAEEFTIDREH........HTWANYFKCGLIVA...SKFlqe9mtklKGMNITFSGTVPT 8 dpVELRVADLAPG-SD........KSWTAYPSGVLWAL...REAghel....TGADVHLASTVPS 9 ldEFSLDAPIVAH-EN........YQWANYVRGVVKHL...QLRnnsf....GGVDMVISGNVPQ 10 ldEFSLDAPIVAH-EN........YQWANYVRGVVKHL...QLRnnsf....GGVDMVISGNVPQ 11 ldEFSLDAPIVAH-EN........YQWANYVRGVVKHL...QLRnnsf....GGVDMVDHGNVPQ 12 tdEFDLREEIAFQ-PK........KMWSNYIRGVIKCL...IERgfef....NGADIVVSGNVPQ 13 ..SEHFGEERKFSLNDlrke....NSWIDYVKGIFWVL...KESdyev....GGIKGRVSGNLPL 14 ..SENVNETVEMEKIEkl......NKWTDYISGVIASF...EKRgyrv....SPVKISVSSNLPI 15 ..SENVNETVEMEKIEkl......NKWTDYISGVIASF...EKRgyrv....SPVKISVSSNLPI 16 ..SENMNETVEMEKIEkl......NRWTDYISGVIKAF...EKRgykv....SPVKISVSSNLPM 17 giKECSLDDIRYQ-KE........DDWANYPKGVIYEF...QQRgyavp...HGFDIVFSGNIPN 18 veFDIDDTNVEKD-ED........RFWANYFKGMITYL...REKydgid...HGFNLYIEANLPS 19 giIEVPLENLRFE-KE........HNWTNYPKGVLHFL...QEAghtid...SGMDIYIYGNIPN 20 giIEISLDHLIFN-KK........DSWTNYAKGVIKYL...QEAghsid...TGMDVYVFGNIPN 21 gvISFTLNELEYD-KQ........AGWANYVKGMILKL...KEAgytfd...HGFELLVEGTIPN 22 gvIEFDLDDVENK-DG........ELWSNYVKGMIVML...KGAgyeid...KGFELLIKGEIPT 23 gvIEFDLDEVEKK-DG........ELWSNYVKGMIVML...KGAgyeid...KGFELLIKGEIPT 24 gtIEFSLDELQFD-TT........HSWANYPKGMVKFL...KESgyqid...SGFNILIEGNIPN 25 laLLTSIFGSFQD-KR........GLWTDYFQGMARVM...KTAganft...HGLNVYINGNLPD 26 ..ESTGKYASDLK-DH........NLFFEVLRFFERKT...GYRv.......PPVRIKQTCNIPV 27 ..EGKFSSGVLQ--GP........NTAAEAVRGLLNME...GVE........AEVGIRVYKGVPP 28 ..GKIVVKGEEFK-DY........RLVNSVISVLREVT...GEP........FGVRFEIHSDIPV 29 ..ISREGA------DT........SLMELCTRMVIEHY...GVD........AGVRVVTSSDLPV 30 ..IEGKVLDNPNI-KP........NLIVRCVKNTLDYF...GLN........YSAYVETKTEIPI 31 ..------------VN........GVERRSIVAERILN...SMD........VTAEVIVESEIPG 32 ..ADKE--------DR........EVIEKIVKELNLEY...ETG........LDYYIEVRKSIPR 33 ..ADEE--------DR........KVIERVVKELNLKY...ETG........LDYYIEVRRSIPR 34 ..------------ND........KDALRFLERLREKY...EFP........-PVKIEIKHYIPK 35 ..FTSHAEGKLREEYR........SKIMEAARRTLKHI...GSD........EKFHFTVRSMFPA 36 ..GEPI--------NR........ERFEIAAAKMAEYC...GR-........-GAEIEVVSDYDA 37 ..GSSL----------........-LAGRMLKAAKAVI...PEG........KGIKIHIKRDLPD 38 ..IEKYGEDYIKS-VR........DRVYNTAIKVLDVI...GGE........-GVDLKILSLFPA 39 ..EFYLDGTLQDEKAT........KKVSQFLDLFRKEA...GLS........LKASVISQNFVPT 40 ..CLILNGNEVNAKEK........EKIQNYMNIVRDLA...GNR........LHARIESENYVPT 41 ..QLILNGEAVNAKES........AKIQRYMEMIRKEA...GIS........EHALIESENFVPT 42 ..QFWLNGEKVSGKEL........EKISKYMDIVRNRA...GID........WYAEIESDNFVPT 43 ..TAALNGEVATGETL........RRISAFLSLVREVA...GSD........QRAVVDTRNTVPT 44 ..LNS--KPVILKNRE........KVFFDYARKILNEP...NVR........--FKIKSKNNFPT 45 ..DQFYINGVLQNDEE........HTKISTIIDQFRQP...GQA........-FVKMETQNNMPT 46 ..DEFYINGQLQNEVE........HAKMSKIIDRYRPA...GEG........-FVRIDTQNNMPT 47 ..IEVDDKNIPTDPDK........NVAGIVAKKMIDDF...NIG........KGVKITIKKGVKA 48 ..IEVDDKNIPTDPDK........NVAGIVAKKMIDDF...NIG........KGVKITIKKGVKA 49 ..LGRFADKLPSEPRE........NIVYQCWERFCQEL...GKQ........IPVAMTLEKNMPI 50 ..LGRFADKLPSEPRE........NIVYQCWERFCQEL...GKQ........IPVAMTLEKNMPI 51 ..AGRFVSKLPAEPKE........NIVYQCWERFCQEI...GRE........VPVAMRLEKNMPI 52 ..AGRFVDKLPANPQE........NIVYDCWQVFAREL...EKKsvvl....KPLTMTLEKNMPI 53 ..AGYFVRKLPKEPQK........NIVYQAYVLFSEQL...KLRganv....KPLRLTLEKNMPI 54 ..IRGIAQPLPLQTER........NTAGAALLSMHRDL...ALP........FGFELEIDKGIPL 55 ..ITGTTTKLSTNPLR........NCAGIAAIATMKML...GIRs.......VGLSLDLHKGLPL 56 ..ITGTTTKLSTNPLR........NCAGIAAIATMKML...GIRs.......VGLSLDLHKGLPL 57 ..VEGY--DVPRD-EN........NVAVISAKALFKMV...GEE........GGVKIRLKKGVRP 58 ..SSGY--PVPNG-ED........NIALFSAKTLFKML...NIE........GGLRIKLKKGIRP 59 ..IGGEGSDNIFLKKN........NIFVNIFYEIYEKL...SGKk.......DNFRFIFQNNIPL 60 ..LVGEGEGIPKFLTN........NIFTKVFYEILKKH...GND........GSFKFLLHNKVPI 61 ..LVGEGEGIPKFLTN........NIFTKVFYEILKKH...GND........GSFKFLLHNKVPI 62 ..IEGYSSGIPKD-QK........NLFIKVYKKTCQSI...GKKp.......KPLKLIQENRVPP 63 ..AETETVAGIRG-TD........NLIYQVAKRTADLY...GKEm.......PPVHVKVWSDIPL 64 ..ETETVAGIPAG-TD........NLIYQVAKRTADLY...GKEm.......PPVHVKVWSDIPL 65 ..DHDLGENIPTD-ER........NLLLTTLSAVLEDK...NVAls......AKFHLKMTSEVPL 66 ..EHQIGKWIPHD-ER........NLLLTIALQIVPDL...Q--........-PRRLKMTSDVPL 67 ..DGEGADQVPMG-PE........HLVVRAVRRGLQAV...GVSa.......AGLVVRCRNAIPH 68 ..DGEGGDQVPLG-PE........HLVVRAVQHGLQAA...GVSa.......AGLAVRCRNAIPH 69 ..FGEGQGEVPLD-GS........HLVVKAIRAGLKAA...DAEv.......PGLRVVCHNNIPQ 70 ..FGEGQGEVPLD-GS........HLVVKAIRAGLKAA...DAEv.......PGLRVVCHNNIPQ 71 ..TGKEAEGVNTD-ES........NLLYQAFVKLYQHIe..QIP........PSVKIEIDLGVPL 72 ..RGRDGEKISTT-KD........NLLYQAIAYFYQQT...GQAi.......PPLKLEIDLEIPL 73 ..LGTELADTPAD-ES........NYVYRAMTLAAKRA...GRTl.......PPARVEIETEVPL 74 llSYEGDGKVPFESNE........NLITQTALYVMRCN...GIKdfp.....RGTHIHVNNPIPL 75 tkESEGYSTVPLRSDA........NLITRTALYVLRCN...NIRnfp.....SGTKVHVSNPIPL 76 tkESEGYSTVPLRSDA........NLITRTALYVLRCNir.NFP........SGTKVHVSNPIPL 77 ..EGDGKEHVSLDVQK........NMITQTSLYVLRCN...NIStfp.....YATKIHVINPIPL 78 qeLVSLLDPLLAQLSEsfhy....HAAFCFLYMFVCLC...PHA........KNIKFSLKSTLPI 79 qeLVSLLDPLLAQLSEsfhy....HAAFCFLYMFVCLC...PHA........KNIKFSLKSTLPI 80 ksIAVLVEEQNLP-KE........KMWLSSGISTFLWL...YTRiigf....NPATVVINSELPY 81 ksIAVLVEEQNLP-KE........KMWLSSGISTFLWL...YTRiigf....NPATVVINSELPY 82 ..ESSMLGRHSAPLPGqgaaakvsPVLEPYIAVLRSLA...ARGysv.....VPHTILVESGIPP 83 lnEIKNINPNNFG-DF........KYCLCAIKNTLDYL...NIEpk......TGFKINISSKIPI 84 liVSFSEDKIYFETDYgkaaevl.SYVRYAIELALEES...DKR........VGIDVSITSQIPV 85 liVSFSEDKIYFETD-ygkaaevlSYVRHAIELVLEEA...DKR........TGVSVSITSQIPV 86 ..SSLGESGLDYQ-RH........PYVVQAVKRFGELR...NIP........-GAEIEIESEIPI 87 ..QSDVYDGPLYD-AP........EHLKSLIGHFVENK...KVE........EPLLIKIQANLPP 88 ..KSDVYDGMLYD-AP........DHLKSLVNRFVELN...NIT........EPLAVTIQTNLPP 89 ..TSDVYDGMLYD-AP........EHLKSIINRFVEKS...GVK........EPLSVKIQTNLPP 90 ..VSSYYSGNLAE-AP........HALKNIKKLFIHLK...KQHdiq.....KNLQLTIESTIPA 91 ..FTGLLEDVPQ--EL........ANIKEVVQQTLHFL...KEDt.......FKGTLTLTSTIPA 92 ..RGGPTFTMTGSASR........AVTAQALDGLRRLTasv---kah9vtdgQHLDVSLDGAIPP 93 ..AGGLSYTMTGTPSR........ALVTQASDGLHRLT...AEFmar9vtnaPHLDVILDGAIPH 94 ..QSAQYSSLPIRWTRrng14npfHYVLAAIHLTEKYA...QEQnkel....SFYHLKVTSELDS 95 ..QSAQYSGMPVRWTRrng14npfHYILAAIRLTEKYA...QEKnill....SFYDLKVTSELDS 96 ..--LHYEPVKFDRNEdri14kqlKYVVTAIEVFEQYV...RSCnmnl....KHFHLTIDSNLAD 97 ..AFGTETRAEH--AS........SHPDPLVRAALGYF...GID........RGVHLTVESDVAP 98 ..RCEVCSPYMALPRE........NTLTRAYARFCQVT...GVH........DGVRVRVVKRIPA 99 ..ETNI--GIPQ--EE........NLVYKGLREFERIT...GIE........INYSIFIQKNIPP 100 ..VHYYNETNEIYVYS........RLVHKTLEWIRHTY...HIK........NHYRINIKKRIPI 101 ..---LKGDFDCPLEE........NSLFKALQILKNFL...KSKnfs10kslDTLAIEVEKNIPT 102 ..EFEIISNFKC--EN........NIIQKAYLLLSRRY...NNElkelf...SKKSLKLTKNIPV 103 ..ESSVALP-----SD........NTIKRAWEMFRKNT...GKE........FGLKVTLKKEIPV 104 ..VI---NACHLETPS........NSIWKSVALFRRYT...GIT........TPVSWRVVKQIPV 105 ..I---INDCQLEISN........NSIWKSTALFRQYT...GIT........DPVSWRVVKHIPI 106 ..LSSNVNELLS--PS........NLIWKSLEIFRRET...QIH........QPVSWHLNKSIPL 107 ..RIGESVTGVVE-AD........DLVVRAAYLLKYAT...NVH........LGADIFVEKRIPV 108 ..LHTEIAGVPH--DS........NLIVRAARGLQEAS...GSP........QGVDIWLDKRLPM 109 ..LHTEIAGVPH--DS........NLIVRAARGLQEAS...GSP........QGVDIWLDKRLPM 110 ..LLTPVNGVEN--ED........NLIVRAARLLMKVA...SESgrlpag..SGADISIEKRLPM 111 ..-----------HED........NLIVRAARLLMKTA...ADSgrlptg..SGANISIDKRLPM 112 ..LLTPVEGVEH--ED........NLIVRAARLLMKTA...ADSgrlptg..SGANISIDKRLPM 113 ..LSPALADVAL--ED........NLIYKAAMALKNAA...QSP........LGADIQLHKVLPM 114 ..VLTPEIPNLKT-EN........NLIYRAAKLLQEKA...NIQ........LGANIHLDKILPM 115 ..VLTPEIPNLKT-EN........NLIYRAAKLLQEKA...NIQ........LGANIHLDKILPM 116 ..VSSHNRFVPDD-QR........NLAYQAAKLIKDRY...NVK........KGVSIMITKVIPV 117 ..EGPDAGQVPLD-RT........NLAARAAEALAARY...GRA........PDVHLHIAKDIPV 118 ..VGEGADQLPTD-ER........NLAWQAAELMAEHV...GRA........PDVSIMIDKSIPV 119 ..LSCGDSPLAND-AT........NLAYRAAQLMINNF...PQAhdny....GGVDITLTKHIPM 120 ..VEG--ADLPTD-ER........NLVYRAARAYLDAA...GAA........GGADLVLHKRLPL 121 ..LHNPVDGMPQ--EA........DLSYRAASLLQKYA...RTP........TGVEIWLDKKIPT 122 ..LHNPVDGMPQ--EV........DLSYRAASLLQKYA...RNP........AGVEIWLDKKIPT 100 110 120 130 | | | | 1 GS....GLSSSAAFVCSATIAI........MAVFGH........NFEKKELA...QLTCECERHI 2 GS....GLSSSAAFVCSATIAI........MAVFGH........NFEKKELA...QLTCECERHI 3 GS....GLSSSAAFVCSATIAI........MAVFGH........NFEKKELA...QLTCECERHI 4 GS....GLSSSAAFVCSATIAI........MAVFGH........NFEKKELA...QLTCECERHI 5 GG....GLSSSAAFCVASTLAI........IRANGIt.......DLTKQDLT...RITVVSEHYV 6 GG....GLSSSAAFCVASTLAI........LHANGVk.......DITKADLT...RITVVCEHYV 7 GG....GLSSSAAFCVASTLAV........LYANGVe.......DISKADLT...RITVVSEHYL 8 GA....GLSSSAALEVVLALAM........NDLYAL........GLRGWQLA...RLCQRAENVY 9 GA....GLSSSASLEVAVGTVL........QQLYHL........PLDGAQIA...LNGQEAENQF 10 GA....GLSSSASLEVAVGTVL........QQLYHL........PLDGAQIA...LNGQEAENQF 11 GA....GLSSSASLEVAVGTVL........QQLYHL........PLDGAQIA...LNGQEAENQF 12 GA....GLSSSAALEVVIGQTF........KELYQL........KISQAEIA...LNGQQAENQF 13 GA....GLSSSASFEVGILETL........DKLYNL........KLDSLSKV...LLAKKAENEF 14 GA....GLSSSAALEVATAYAI........SEYFGF........NVPKLELV...---------- 15 GA....GLSSSAALEVATAYAI........SEYFGF........NVPKLELV...KIAREAEVEF 16 GA....GLSSSAALEMATAYAI........SEHFGF........HLPKLELV...KIAREAEVEF 17 GA....GLSSSASIELLMGVVL........QSYFHP........EVDALELV...KMAQHAENHF 18 GS....GLSSSAAIEMLMGIIL........KDEFNL........DVDRVSLA...KMGQRTENEF 19 GS....GLSSSSSLELLIGVIV........EKLYDI........KLERLDLV...KIGKQTENDF 20 GS....GLSSSSSLELLIGIMA........EELFDL........KLDRLDLV...KIGKRTENDF 21 GA....GLSSSASLELLVGVVL........EDLFDL........AIDRLALV...QTGKKVENEF 22 AS....GLSSSASLELLVGVVL........DDLFKL........SVPRLELV...QLGQKTENDY 23 AS....GLSSSASLELLVGVVL........DDLFNL........NVPRLELV...QLGQKTENDY 24 GA....SLSSSASIEILMGWLL........KALFNL........EVERLELI...ELGRKVENQF 25 GA....GLSSSASLEMLVGTIL........NSLFDG........GFEPLELV...QFGVKVENDY 26 SS....GLGSSAAVIVAALHIA........NEGTGR........NLSREDLM...KLAVELEGHP 27 GR....GLGSSGASAAAAVAAV........SHALAL........EVPVDRLV...FYAGLGERAA 28 GK....GLKSSSAAANSLTKAL........VEALRL........NIDDLSIV...KLGVEAAKRA 29 AS....GLSSSSAASNATVMAV........SSLLSDefglq...PMEDFEML...NMAVDASLQA 30 KS....GLSSSSATSNAVVLAT........FDALGE........KIDDELIL...NLGIKSSFDE 31 GS....GLGSSSAFVNALICAV........KKMKGE........ELNAFEIL...RSNARFSLEA 32 HI....GLGSTTQLTLAIASAI........LRIAKK........DIPIEEVAfslKRARESGAGL 33 HI....GLGSTTQLTLAIASAI........LRIAKK........EVPIEDVA...---------- 34 WV....GLGFHTTLALTLGLGI........NRIYNL........GLSLEDIA...LTVRRGLITA 35 HS....GLGSGTQLSLATARLV........AEYHGM........KFTARELA...HIVGRGGTSG 36 HV....GLGSGTQISLAVGRAF........SELYGL........NLTTRQIA...EIMGRGGTSG 37 HV....GLGSGTQAALSVAAAI........NEIYGL........GKSVRELA...VAVGRGGTSG 38 HS....GLGSGTQLSLAVGKLI........SKIYNK........EMNAYNIA...KITGRGGTSG 39 AA....GLASSASGLAALAGAC........NTALKL........GLDDLSLS...RFARRGSGSA 40 AA....GLASSASAYAALAAAC........NEALSL........NLSDTDLS...RLARRGSGSA 41 AA....GLASSASAYAALAGAC........NEALQL........GLSDKDLS...RLARRGSGSA 42 AA....GLASSASAYAALAAAC........NQALDL........QLSDKDLS...RLARIGSGSA 43 GA....GLASSASGFAALAVAA........AAAYGL........ELDDRGLS...RLARRGSGSA 44 AA....GLASSSSGFASIAACI........LKYFN-........KYSCNSAS...NLARVGSASA 45 AA....GLSSSSSGLSALVKAC........DQLFDT........QLDQKALA...QKAKFASGSS 46 AA....GLSSSSSGLSALVKAC........NAYFKL........GLDRSQLA...QEAKFASGSS 47 GS....GLGSSAASSAGTAYAI........NELFKL........NLDKLKLV...DYASYGELAS 48 GS....GLGSSAASSAGTAYAI........NELFKL........NLDKLKLV...DYASYGELAS 49 GS....GLGSSACSVVAALMAM........NEHCGK........PLNDTRLL...ALMGELEGRI 50 GS....GLGSSACSVVAALMAM........NEHCGK........PLNDTRLL...ALMGELEGRI 51 GS....GLGSSACSVVAGLMAM........NEFCDR........PLDKTTLL...GLMGELEGRI 52 GS....GLGSSACSIVAALDAL........NQFHAS........PLDETELL...ALMGEMEGKI 53 GS....GLGSSACSIVAALVAL........NQFHNE........PFSKMELL...EMMGELEGRI 54 SS....GMGGSAASCVAALLAA........NALLEE........PLRREHLY...RYALDGEAVA 55 GS....GLGSSAASAAAAAVAV........NEIFGR........KLGSDQLV...LAGLESEAKV 56 GS....GLGSSAASAAAAAVAV........NEIFGR........KLGSDQLV...LAGLESEAKV 57 KS....GLGSSGASSVAGALAA........ARVLGV........DNDELIIM...-AALEGEKAA 58 KS....GLGSSGASAVAGALGA........AKLLGV........SNDELILK...AAMKGEEKAS 59 SR....GLGSSSAVIVGAIASA........YYMSGF........KVEKECIL...DEALIYENHP 60 TR....GMGSSSAMIVGAVASA........FAFLGF........AFDRENIL...NTALIYENHP 61 TR....GMGSSSAMIVGAVASA........FAFLGF........DFDRENIV...NTALIYENHP 62 AR....GLGSSATAIVGGIEAA........LALHKV........ELPLKEKL...KIAFEFEKHP 63 AR....GLGSSAAAIVAAIELA........DELCGL........KLSEADKL...HLASLEEGHP 64 AR....GLGSSAAAIVAAIELA........DELCGL........KLSEADKL...HLASLEEGHP 65 AR....GLGSSSSVIIAGIELA........NQLAKL........NLTSDEKL...KLACEIEGHP 66 AR....GLGSSSSVIVAGIELA........NQLGQL........NLSDHEKL...QLATKIEGHP 67 SR....GLGSSAAAVVGGLAVV........NGFVAQidst....PLSNAQLI...QLASEFEGHP 68 SR....GLGSSAAAVVGGLAAV........NGLVVQtdss....PSSDAELI...QLASEFEGHP 69 SR....GLGSSAAAAVAGVAAA........NGLADF........PLTQEQIV...QLSSAFEGHP 70 SR....GLGSSAAAAVAGVAAA........NGLADF........PLTQEQIV...QLSSAFEGHP 71 AR....GLGSSATAIVGGLVAA........NQLAGE........PLSQLQVM...ELAIAMEGHP 72 AR....GLGSSATAIVGGLLAA........NQAAGN........PCTTSEIL...QMAIAMEGHP 73 AR....GLGSSAAALVAGVVAG........NELLGR........PLDDETVL...DVTAREEGHP 74 GR....GLGSSASAIVAGVYLG........NEIGNL........KLDKYRLL...DYCLMIERHP 75 GR....GLGSSGAAVVAGVILG........NEVAQL........GFSKQRML...DYCLMIERHP 76 GR....GLGSSGAAVVAGVILG........NEVAQL........GFSKQRML...DYCLMIERHP 77 GR....GMGSSGSAAIAGVMLA........NEIAKL........GLSKLQMM...DYVLMIERHP 78 GA....GLGSSASISVSLALAM........AYLGGLigs10klsENDKHIVN...QWAFIGEKCI 79 GA....GLGSSASISVSLALAM........AYLGGLigs10klsENDKHIVN...QWAFIGEKCI 80 GS....GLGSSAALCVALTAALlas11trgNGWSSL........DETNLELLn..KWAFEGEKII 81 GS....GLGSSAALCVALTAALlas11trgNGWSSL........DETNLELLn..KWAFEGEKII 82 RA....GLGSSAASMVAYALSY........SAMHGD........PLSAEDLY...SVAMEGEKIA 83 SC....GLGSSASITIGTIKAV........SGFYNK........ELKDDEIA...KLGYMVEKEI 84 GA....GLGSSAAVAVATIGAV........SRLLGL........ELSKEEIA...KLGHKVELLV 85 GA....GLGSSAAVAVATIGAV........SKLLDL........ELSKEEIA...KMGHKVELLV 86 GS....GLGSSAAVIVATIAAL........NAEFDG........DMDKEAIF...QMAKQVEIDV 87 SR....GLGSSAAVAVAFIRAS........YDYLGL........PLTDKELL...ENADWAERIA 88 SR....GLGSSAAVAVAFVRAS........YDFLGK........SLTKEELI...EKANWAEQIA 89 SR....GLGSSAAVAVAFVRAS........YDFMDQ........PLDDKTLI...KEANWAEQIA 90 ER....GMGSSAAVATAVTRAF........YDYLAF........PLSREILL...ENVQLSEKIA 91 ER....GMGSSAATAVAIVRSL........FDYFDY........AYTYQELF...ELVSLSEKIA 92 GR....GLGSSAANARAIILAL........ADLFGR........ELTEGEVF...DLVQEAENLT 93 GR....GLGSSAAGSRAIALAL........ADLFGH........ELAEHTAY...ELVQTAENMA 94 SNgrkyGLGSSGAVTVGTVKAL........NIFYDL........GLENEEIF...KLSALAHLAV 95 SNgrkyGLGSSGAVTVATVKAL........NVFYAL........NLSQLEIF...KIAALANLAV 96 NSgqkyGLGSSAAVLVSVVKAL........NEFYGL........ELSNLYIY...KLAVIANMKL 97 GS....GLGGSGAFLVALATAL........SHLTGD........PLTPAAAA...RAAFRIERAL 98 GS....GLGGGSADAAALLCGL........DTLFGT........TLSARVLR...EVAYSVGSDV 99 GA....GLGGGSSNLAVVLKKV........NELLGS........PLSEEELR...ELVGSISADA 100 GA....GLGGGSSNAAAIMKYI........LEFEG-........-IKEINYK...DVVNKLGADI 101 QA....GLGGGSTDAGGLLYHL........NQIFDW........RLSLEELY...SMGSLVGADT 102 CA....GLGGGSSDCASFLLLI........NETLNL........KLNLQELI...NLSIQLGSDI 103 GS....GLGGGSSNAAAVLRYL........GEVFKI........PL--EDLL...NIAAQVGSDV 104 GA....GLAGGSSNAATALFAL........NQIFKT........GLSDEEMR...SLAEQLGVDT 105 GS....GLAGGSSNAATALFAL........NQMFQT........GLSDEELR...SLAEKVGMDT 106 QS....GLGGGSSNAATALYAL........NEHFQT........HIPITTLQ...LWAREIGSDV 107 GG....GFGGGSSDAATVLLVL........NALWHT........RLDVAVLA...ALGLRLGADV 108 GG....GIGGGSSDAATTLLAL........NHLWQL........GWDEDRIA...ALGLRLGADV 109 GG....GIGGGSSDAATTLLAL........NHLWQL........GWDEDRIA...ALGLRLGADV 110 GG....GLGGGSSNAATVLVAL........NHLWQC........GLSIDELA...TLGLTLGADV 111 GG....GLGGGSSNAATVLVAL........NHLWQC........GLSMDELA...EMGLTLGADV 112 GG....GLGGGSSNAATVLVAL........NHLWQC........GLSMDELA...EMGLTLGADV 113 GG....GIGGGSSNAATTLVAL........NYLWQT........GLSDDQLA...EIGLALGADV 114 GG....GVGGGSSNAATALVSL........NYLWQA........NLSIDELA...KLGLTLGADV 115 GG....GVGGGSSNAATALVSL........NYLWQA........NLSIDELA...KLGLTLGADV 116 AA....GLAGGSSDAAATLRGL........NRLWNL........NLSAETLA...ELGAEIGSDV 117 AG....GMAGGSADGAGALLAC........DALWGT........GASREELL...EICAGLGSDV 118 AG....GMAGGSADAAAVLVAM........NSLWEL........NVPRRDLR...MLAARLGSDV 119 AA....GLAGGSADAAAVLVGL........DLLWNL........GLTRPELE...QLAAQLGSDI 120 AS....GLGGGSSDAASTLLAL........AELYPAp.......DHRPVDLP...ALALTLGADV 121 GA....GLGGGSSDAATVLLVL........NRWWQC........GLTQRQLI...DSGAALGADV 122 GA....GLGGGSSDAATVLLVL........NRWWQC........GLTQRQLI...DSGAALGADV 140 150 160 170 18 | | | | 1 G........TQSGGMD.QAISI--........-----------.-------.------------- 2 G........TQSGGMD.QAISI--........-----------.-------.------------- 3 G........TQSGGMD.QAISI--........-----------.-------.------------- 4 G........TQSGGMD.QAISI--........-----------.-------.------------- 5 G........VNTGGMD.QCASVCG........E----------.-------.------------- 6 G........VNTGGMD.QCASVYGep......DKALLIQFK--.-------.------------- 7 G........LNNGGMD.QCASVYGeq......GKALFIQFKP-.-------.------------- 8 V........GAPVGIM.DQTAS--........-----------.-------.------------- 9 V........GCNCGIM.DQLISAL........-----------.-------.------------- 10 V........GCNCGIM.DQLISAL........-----------.-------.------------- 11 V........GCNCGIM.DQLISAL........-----------.-------.------------- 12 V........GCNCGIM.DQMISAQgqa.....-----------.-------.------------- 13 V........GVPCGIL.DQFAVVFgregnv..IFLDTHTLDYE.YIPF---.------------- 14 -........-------.-------........-----------.-------.------------- 15 V........GVRCGIM.DQFTAVFgkkdha..IFLDTMTLEYE.YVPLKLE.GYEINLVDSNVKH 16 V........GVRCGIM.DQFTSAFgkkdha..IFLDTMTLEYE.YVPLKLE.GYEINLVDSNVKH 17 I........GVNCGIM.DQFAIGMgkkhha..MLLNCDTLDYE.YSKLNVS.GLALVIANTNKKR 18 I........GLNSGIM.DQFACIMgkknsa..IFLDCNTLKYE.YLPLALG.DYEIIIMATNNPH 19 I........GVNSGIM.DQFAIGMgadqca..IYLDTNTLKYD.LVPLDLK.DNVVVIMNTNKRR 20 I........GVNSGIM.DQFAIGMgaekka..IYLDTKTLEYD.LVPLDLG.DNVIVIMNTNKRR 21 I........GVNSGIM.DQFAIGFgevdka..ILLDTNTLKYE.MVPVKLD.GYAVVIMNTNKRR 22 I........GVNSGIL.DQFAIGFgevkka..ILLDCNTLKYE.MVPVELR.DYDIVIMNTNKPR 23 I........GVNSGIL.DQFAIGFgevkka..ILLDCNTLKYE.MVPVELR.DYDIVIMNTNKPR 24 I........GVNSGIM.DQFIVGMgrkdqa..ILLDTATLEYH.YVPTEFG.DYVISIMNTNKRR 25 I........GVNSGVM.DQFAIEMgranqa..TLLDTNTMKYE.YLPVEMG.DNVIVIMNTNKRR 26 Dnvv53ekvPFEDAVF.NIKNSCQ........FLAKIAAGKIK.EALKYVG.DRLHQNYRINGNK 27 Agqp63envSFRDAVR.NFSRAAG........IVAAAVNGDLKsMGALMMS.DEIVEPRRRSYVP 28 G........VTITGAF.DDACASY........FGGLCITDNYE.MEILVKR.EINPETVV----- 29 G........VSVTGAY.DDASASF........YGGLTVTDNME.RRIILRE.PMEN--------- 30 K........LTVTGAY.DDATASY........YGGITITDNIE.RKILKRD.KMRDDLNVLILIP 31 G........ISYTGAF.DDASASM........LGGFVVSDNRK.MRLIRTD.E------------ 32 Y........I------.-------........-----------.-------.------------- 33 -........-------.-------........-----------.-------.------------- 34 L........-------.-------........-----------.-------.------------- 35 I........GVAS---.-------........-----------.-------.------------- 36 Ig.......-------.-------........-----------.-------.------------- 37 Igv......-------.-------........-----------.-------.------------- 38 Igig25dkeDFRPSSA.SKGVKPA........PIIFRHDFDWE.TILIIPK.GEHV--------- 39 C........RSIFGGF.VEWEKGHddl9yakpVPSDSFEDDLA.MVFVLIN.D------------ 40 S........RSIFGGF.AEWEKG-........-----------.-------.------------- 41 S........RSIYGGF.AEWEK--........-----------.-------.------------- 42 S........RSIYGGF.AEWEKGY........-----------.-------.------------- 43 S........RSIFGGF.AVWHA--........-----------.-------.------------- 44 A........RAIYGGF.-------........-----------.-------.------------- 45 S........RSFFGPV.AAWDKDS........GAIYKVETDLK.MAMI---.------------- 46 S........RSFYGPL.GAWDKDS........GEIYPVETDLK.LAMIM--.------------- 47 Sga116evkDKVYGIT.ISGSGPS........IIAFPKEEFID.EVENILR.DYYENTIRTEVGK 48 X........DKVYGIT.ISGSGPS........IIAFPKEEFID.EVENILR.DYYENTIRTEVGK 49 Sgsi59aqyRRQDCIA.HGRHLAG........FIHACYSRQPE.LAAKLMK.DVIAEPYRERLLP 50 Sgsi60aqyRRQDCIA.HGRHLAG........FIHACYSRQPE.LAAKLMK.DVIAEPYRERLLP 51 Sgsv60aqyRRQDCIS.HGRYLAG........FIHACHTRQPQ.LAAKLMQ.DVIAEPYRTRLLP 52 Sgsi60aqyRRQDIVA.HGRYLAG........FIHACHTQQPE.LAAKMIK.DVIAEPYREKLLP 53 Sgsi60ksyTRQNVIA.HGRHLGG........FVHACHTHQEN.LAAIMMK.DVIAEPYRESLLP 54 Sgsr57dpyLLPDIVT.QSANLAL........VLAGCYHGDAE.LVRAGLR.DVLIEPRRAPLIA 55 Sgyh61teiPMVHHVW.NSSQAAA........LVAAVLEGDAV.MLGKALSsDKIVEPTRAPLIP 56 Sgyh61teiPMVHHVW.NSSQAAA........LVAAVLEGDAV.MLGKALSsDKIVEPTRAPLIP 57 Sgsp58ekvPLKDAIK.NLAMASS........LVLALKEGDIE.TVGRLLD.DNLALPYRKKLMP 58 Geph57smvPLKDAVK.NIAMASS........LILALKEGDLE.TIGRLLD.DNLALPYRKKLMP 59 Dnia55knlSFNDAVF.NLSHASF........LTACFLEKKYE.FLKFASQ.DKLHEINRMKNLP 60 Dnit55krySVQESVF.NLSHASL........MTMAIVQGKWD.LLRCCSK.DRMHQYKRMQTYP 61 Dnit55krySVQESVF.NLSHASL........MTMAIVQGKWD.LLRCCSK.DRMHQYKRMQTYP 62 Dnii55kkvELKEAVF.NVQRSAL........FVSALLTKDYK.LLREAVR.DKLHQPYREKLVP 63 Dnag54kefPYADAVK.ASAVSNI........LIAAIMSKDWP.LVGKIMKkDMFHQPYRAMLVP 64 Dnag54kefPYADAVK.ASAVSNI........LIAAIMSKDWP.LVGKIMKkDMFHQPYRAMLVP 65 Dnva54nelTYKEAVA.ASSIANV........LTASLLTNNLE.VAGQMMEaDRFHESYRASLIP 66 Dnva59keaVAASSIA.NVAVAAL........LAGDMVTAG--.--QAIEG.DLFHERYRQDLVR 67 D........NAAAAVL.GGAVVSW........VDRSYDQPDYC.AVPLRLH.PDIH--------- 68 Dnaa35pdi-------.-------........-----------.-------.------------- 69 Dnaa62tevTHIDARF.NVSRVAV........MIVALQQ-RPD.LLWEGTR.DRLHQPYRAEVLP 70 Dnaa62tevTHIDARF.NVSRVAV........MIVALQQ-RPD.LLWEGTR.DRLHQPYRAEVLP 71 Dnvv55tefSRADAIF.NTAHLGL........LLRGLATGKGE.WLKTALQ.DKLHQPYRKALIP 72 Dnva55hqyDRSAAIF.NASHLAL........LVQAFSQGRGD.WLALALQ.DQIHQPYRQSLIP 73 Dnva55reySRADTVH.ALSHAAL........LAAALAQGRLD.LLRHAMQ.DYVHQVWRAPLVP 74 -........-------.-------........-----------.-------.------------- 75 Dnit90kayPTQDLVF.NLQRLAVlt......TALTMDPPNAD.LIYPAMQ.DRVHQPYRKTLIP 76 Dnit90kayPTQDLVF.NLQRLAVlt......TALTMDPPNAD.LIYPAMQ.DRVHQPYRKTLIP 77 Dnvm82tsyGRTDVVY.NLQRLALlt......TALGQTPINPH.LVYEVMK.DKVHQPYRASLIP 78 H........GTPSGID.NAVATYG........NALLFEKDSH-.-------.------------- 79 H........GTPSGID.NAVATYG........NALLFEKDS--.-------.------------- 80 H........GKPSGID.NTVSAYG........NMIKFCSGEIT.RLQS---.------------- 81 H........GKPSGID.NTVSAYG........NMIKFCSGEIT.RLQS---.------------- 82 H........GKPSGVD.VTIAVRG........GVLAYRRG---.-------.------------- 83 Q........GKASITD.TSTITYK........GILEIKNNKFR.KIK----.------------- 84 Q........GASSGID.PTVSAVG........GFLYYKQGKFE.PLPFME-.------------- 85 Q........GASSGID.PTVSAIG........GFLYYKQGEFE.HLPFV--.------------- 86 Q........GRASGID.PFISTFGg.......SWLFPE-----.-------.------------- 87 H........GKPSGID.TKTIVTN........QPVWYQKGEVE.ILKTLDL.DGYMVVI------ 88 H........GKPSGID.TQTIVSG........KPVWFQKGQAE.TLKTLSL.DGYMVVI------ 89 H........GKPSGID.TQTIVSN........KPVWFKQGQAE.TLKSLKL.NGYMVV------- 90 H........GNPSGID.AAATSSL........QPIYFTKG---.-------.------------- 91 H........GNPSGID.AAATSGA........DPLFFTRGFP-.-------.------------- 92 H........GRASGVD.AVTVGAT........APLLF------.-------.------------- 93 H........GRASGVD.AMTVGAS........RPLLFQQGRTE.RLAIGCD.S------------ 94 Q........GNGSCGD.IAASCYG........GWIAFSTFDHD.WVNQKVT.TETLTDLLAMDWP 95 Q........DNGSCGD.IAASCYG........GWIAFSTFDHP.WLQEQET.QHSISELLALDWP 96 Q........SLSSCGD.IAVSVYS........GWLAYSTFDHD.WVKQQME.ETSVNDVLEKNWP 97 C........GRPVGQQ.DHWTAAS........GAAIELRIAPD.GTADA--.------------- 98 P........FFLASQA.ACVLGGG........EQLVPLVPKTG.YLGLLVW.PGL---------- 99 P........FFLLGKS.AIGRGKG........EVLEPVETE--.-------.------------- 100 P........FFLSGYK.TAYIS--........-----------.-------.------------- 101 N........FFIS---.-------........-----------.-------.------------- 102 A........FFLSGFHsANVSSCG........EIIEEFEDDIP.NLKWTFP.QISCQ-------- 103 P........FFLYGGT.ALVRGRG........EIVEKLED---.-------.------------- 104 P........FFFSTGA.ALGVARG........EKIIAL-----.-------.------------- 105 P........FFFSSGS.ALGLGRG........EKV--------.-------.------------- 106 P........FF-----.-------........-----------.-------.------------- 107 P........VFVHGCN.AWAEGVG........ECLTPMILPGA.AYLLLDP.GVCVPTRELFLDP 108 P........VFTRGRA.AFAEGVG........EKLTPVDIPEP.WYLVVVP.QVLVSTAEIFSDP 109 P........VFTRGRA.AFAEGVG........EKLTPVDIPEP.WYLVVVP.QVLVSTAEIFSDP 110 P........VFVRGHA.AFAEGVG........EILTPVNPPEK.WYLVAHP.GVSIPTPVIFKDP 111 P........VFVRGHA.AFAEGVG........EILTPVDPPEK.WYLVAHP.GVSIPTPVIFKDP 112 P........VFVRGHA.AFAEGVG........EILTPVDPPEK.WYLVAHP.GVSIPTPVIFKDP 113 P........VFTRGFA.AFAEGVG........EELSAVEPEEK.WYLVVRP.AVSIATKDIFTHP 114 P........IFVHGHA.AFAEGVG........EKITYCEPAEK.WFVILKP.DDSISTAVIFQDP 115 P........IFVHGHA.AFAEGVG........EKITYCEPAEK.WFVILKP.DDSISTAVIFQDP 116 S........FCVYGGT.ALATGRG........EKIKHISTPPH.CWVILAK.P------------ 117 P........FSLVGGA.ALGTGRG........ERLAELEVGGD.-------.------------- 118 P........FALHGGT.ALGTGRG........EELA-------.-------.------------- 119 P........FCIGGGT.AIATGRG........EILDPLPDGNC.FWVVLAK.HRSI--------- 120 P........FFLLGGA.ALAEGVG........ERLTPVDD---.-------.------------- 121 P........FFIFGKN.AFARGIG........DRLDEMDIPKQ.WYVIVKP.PVHVSTAKIFTHE 122 P........FFIFGKN.AFARGIG........DRLDEMDIPKQ.WYVIVKP.PVHVSTAKIFTHE 0 | 1 ----- 2 ----- 3 ----- 4 ----- 5 ----- 6 ----- 7 ----- 8 ----- 9 ----- 10 ----- 11 ----- 12 ----- 13 ----- 14 ----- 15 EL--- 16 EL--- 17 TL--- 18 T---- 19 EL--- 20 EL--- 21 EL--- 22 AL--- 23 AL--- 24 EL--- 25 EL--- 26 KMK-- 27 CYTQV 28 ----- 29 ----- 30 NLE-- 31 ----- 32 ----- 33 ----- 34 ----- 35 ----- 36 ----- 37 ----- 38 ----- 39 ----- 40 ----- 41 ----- 42 ----- 43 ----- 44 ----- 45 ----- 46 ----- 47 G---- 48 GVEVV 49 GF--- 50 GF--- 51 GF--- 52 GF--- 53 NFAEV 54 GF--- 55 GMEAV 56 GMEAV 57 WFDEV 58 WFDEI 59 ELFEV 60 VLF-- 61 VLF-- 62 GLS-- 63 ELSKV 64 ELSKV 65 ELQ-- 66 EF--- 67 ----- 68 ----- 69 ----- 70 ----- 71 GYDAV 72 AYDQ- 73 GLSDI 74 ----- 75 GLTEI 76 GLTEI 77 GLQNI 78 ----- 79 ----- 80 ----- 81 ----- 82 ----- 83 ----- 84 ----- 85 ----- 86 ----- 87 ----- 88 ----- 89 ----- 90 ----- 91 ----- 92 ----- 93 ----- 94 EL--- 95 GL--- 96 GL--- 97 ----- 98 ----- 99 ----- 100 ----- 101 ----- 102 ----- 103 ----- 104 ----- 105 ----- 106 ----- 107 DL--- 108 LL--- 109 LL--- 110 QL--- 111 EL--- 112 EL--- 113 QL--- 114 NL--- 115 NL--- 116 ----- 117 ----- 118 ----- 119 ----- 120 ----- 121 GL--- 122 SL---