; SAM: prettyalign v3.2 (July 31, 2000) compiled 08/11/00_16:27:51 ; (c) 1992-2000 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequences correspond to the following labels: ; 1 T0115-outer ; 2 gi|140422|sp|P24209|IPK_ECOLI_7:190 ; 3 gi|549526|sp|P30753|IPK_SALTY_7:190 ; 4 gi|1175665|sp|P42805|IPK_PSEAE_9:186 ; 5 gi|1074864|pir||A64173_34:212 ; 6 gi|9950924|gb|AAG08056.1|AE004880_12_9:186 ; 7 gi|1175664|sp|P45271|IPK_HAEIN_26:204 ; 8 gi|6831546|sp|O85253|GAL1_THENE_1:191 ; 9 gi|2494673|sp|P96993|GAL1_STRMU_21:219 ; 10 gi|6831547|sp|P56838|GAL1_THEMA_1:191 ; 11 gi|6648061|sp|P04948|KHSE_BACSU_8:240 ; 12 gi|7379787|emb|CAB84355.1|_12:189 ; 13 gi|4206187|gb|AAD11510.1|_30:228 ; 14 gi|80285|pir||B25364_8:239 ; 15 gi|4995690|emb|CAB44216.1|_30:228 ; 16 gi|147980|gb|AAA83915.1|_3:241 ; 17 gi|7226111|gb|AAF41285.1|_12:189 ; 18 gi|266419|sp|P00547|KHSE_ECOLI_3:242 ; 19 gi|6967628|emb|CAB72618.1|_1:233 ; 20 gi|6321814|ref|NP_011890.1|_5:290 ; 21 gi|125395|sp|P27722|KHSE_SERMA_3:242 ; 22 gi|125393|sp|P04947|KHSE_FREDI_4:241 ; 23 gi|6707009|gb|AAF25548.1|AF109295_3_21:218 ; 24 gi|7472024|pir||G75280_7:240 ; 25 gi|9656736|gb|AAF95327.1|_15:192 ; 26 gi|729557|sp|P39574|GAL1_BACSU_21:219 ; 27 gi|4614|emb|CAA37083.1|_5:289 ; 28 gi|6225403|sp|O84902|GAL1_LACCA_21:218 ; 29 gi|7450509|pir||B64651_3:230 ; 30 gi|120900|sp|Q00052|GAL1_LACHE_22:219 ; 31 gi|9107876|gb|AAF85442.1|AE004071_10_22:200 ; 32 gi|7450510|pir||C71940_3:230 ; 33 gi|5733507|gb|AAD49612.1|_23:220 ; 34 gi|2497515|sp|Q58504|KHSE_METJA_3:296 ; 35 gi|120898|sp|P06976|GAL1_ECOLI_21:180 ; 36 gi|208230|gb|AAA72509.1|_21:180 ; 37 gi|6225592|sp|O67332|KHSE_AQUAE_3:231 ; 38 gi|8928118|sp|Q9ZB10|GALK_STRTR_21:219 ; 39 gi|6919915|sp|P72663|IPK_SYNY3_8:179 ; 40 gi|7490646|pir||T40495_4:271 ; 41 gi|9656932|gb|AAF95506.1|_3:248 ; 42 gi|2501753|gb|AAC48872.1|_21:180 ; 43 gi|7532410|gb|AAF63224.1|_49:300 ; 44 gi|4927412|gb|AAD33097.1|AF082525_1_49:300 ; 45 gi|7450508|pir||F72364_1:228 ; 46 gi|7434441|pir||H75080_4:234 ; 47 gi|1170650|sp|P44504|KHSE_HAEIN_3:250 ; 48 gi|125390|sp|P07128|KHSE_BRELA_9:245 ; 49 gi|2292917|emb|CAA68163.1|_49:215 ; 50 gi|2736186|gb|AAB94084.1|_49:215 ; 51 gi|125391|sp|P08210|KHSE_CORGL_9:245 ; 52 gi|2497514|sp|P73646|KHSE_SYNY3_4:239 ; 53 gi|6537164|gb|AAF15552.1|_49:215 ; 54 gi|7543733|gb|AAF63635.1|_49:215 ; 55 gi|9937364|gb|AAG02424.1|AF290087_1_6:177 ; 56 gi|9656105|gb|AAF94749.1|_41:203 ; 57 gi|9937372|gb|AAG02430.1|AF290089_1_5:177 ; 58 gi|9107373|gb|AAF85023.1|AE004035_2_16:255 ; 59 gi|9937379|gb|AAG02435.1|AF290091_1_6:176 ; 60 gi|8928130|sp|O27995|KIME_ARCFU_1:151 ; 61 gi|2497513|sp|P72535|KHSE_STRPN_1:225 ; 62 gi|8928178|sp|O59291|KIME_PYRHO_6:186 ; 63 gi|586879|sp|P37550|IPK_BACSU_7:171 ; 64 gi|1730045|sp|P52991|KHSE_LACLA_1:231 ; 65 gi|9937395|gb|AAG02447.1|AF290095_3_4:203 ; 66 gi|2497517|sp|Q58487|KIME_METJA_1:176 ; 67 gi|9937388|gb|AAG02442.1|AF290093_3_4:203 ; 68 gi|2497516|sp|Q92209|KHSE_CANAL_5:142 ; 69 gi|7521143|pir||E72511_33:280 ; 70 gi|6919916|sp|Q9X1A3|IPK_THEMA_14:161 ; 71 gi|9937380|gb|AAG02436.1|AF290091_2_18:156 ; 72 gi|8928195|sp|Q9V187|KIME_PYRAB_6:185 ; 73 gi|3913721|sp|P56599|GAL1_CANMA_40:207 ; 74 gi|2660644|emb|CAA04516.1|_1:127 ; 75 gi|6919911|sp|O67060|IPK_AQUAE_6:155 ; 76 gi|6016092|sp|O42821|GAL1_CANPA_40:219 ; 77 gi|9937365|gb|AAG02425.1|AF290087_2_18:157 ; 78 gi|9937381|gb|AAG02437.1|AF290091_3_3:206 ; 79 gi|2494674|sp|P56091|GAL1_CANAL_41:223 ; 80 gi|7471511|pir||E75254_14:166 ; 81 gi|321817|pir||PC1178_3:131 ; 82 gi|9937394|gb|AAG02446.1|AF290095_2_17:184 ; 83 gi|6919909|sp|O05596|IPK_MYCTU_10:160 ; 84 gi|7434202|pir||F71144_3:176 ; 85 gi|7190224|gb|AAF39061.1|_5:151 ; 86 gi|1170651|sp|P45836|KHSE_MYCLE_14:179 ; 87 gi|9937408|gb|AAG02456.1|AF290099_2_19:173 ; 88 gi|8894769|emb|CAB95929.1|_25:179 ; 89 gi|7450512|pir||D71103_2:212 ; 90 gi|9937393|gb|AAG02445.1|AF290095_1_6:162 ; 91 gi|6919912|sp|O83386|IPK_TREPA_8:173 ; 92 gi|8894781|emb|CAB95941.1|_7:165 ; 93 gi|9937401|gb|AAG02451.1|AF290097_2_19:172 ; 94 gi|8979328|dbj|BAA99162.1|_5:135 ; 95 gi|6919913|sp|O84810|IPK_CHLTR_5:154 ; 96 gi|9937373|gb|AAG02431.1|AF290089_2_18:155 ; 97 gi|9695270|dbj|BAB07790.1|_31:204 ; 98 gi|9937386|gb|AAG02440.1|AF290093_1_8:165 ; 99 gi|9695271|dbj|BAB07791.1|_35:172 ; 100 gi|6968538|emb|CAB73359.1|_4:177 ; 101 gi|7447991|pir||F75161_26:170 ; 102 gi|2128859|pir||G64479_27:178 ; 103 gi|1730046|sp|Q10603|KHSE_MYCTU_17:180 ; 104 gi|3183231|sp|O26918|Y830_METTH_18:144 ; 105 gi|6323864|ref|NP_013935.1|_8:219 ; 106 gi|2804172|dbj|BAA24409.1|_8:218 ; 107 gi|9711346|dbj|BAB07817.1|_21:180 ; 108 gi|8928161|sp|Q9Y946|KIME_AERPE_6:169 ; 109 gi|7447990|pir||E69207_28:169 ; 110 gi|1170660|sp|P46086|KIME_ARATH_4:226 ; 111 gi|7463680|pir||E70185_16:143 ; 112 gi|6899611|gb|AAF31014.1|AE002158_12_25:149 ; 113 gi|5578718|gb|AAD45421.1|L77688_1_4:224 ; 114 gi|3183371|sp|Q58822|YE27_METJA_13:200 ; 115 gi|629246|pir||S44963_26:168 ; 116 gi|6919910|sp|O25984|IPK_HELPY_37:149 ; 117 gi|3183451|sp|O28190|YK89_ARCFU_15:128 ; 118 gi|7445272|pir||B75078_11:116 ; 119 gi|2909376|emb|CAA76303.1|_15:128 ; 120 gi|7447992|pir||H69314_4:151 ; 121 gi|7429727|pir||F71066_11:134 ; 122 gi|7429728|pir||D71246_19:123 10 20 30 40 | | | | 1 MREIMKVRVKAPCTSANLGVGFDVF...GLCLK..E.....PYDVIEVEA..IDDKEII...... 2 SPAKLNLFLYITGQRAD---GYHTL...QTLFQflD.....YGDTISIEL..RDDGDIR...... 3 SPAKLNLFLYITGQRAD---GYHTL...QTLFQflD.....YGDTLHIEP..RHDGEIH...... 4 APAKLNLFLHILGRRDD---GYHEL...QTLFQflD.....HGDELHFEA..RQDGQVR...... 5 SPAKLNLFLYINGKFPN---GYHEL...QTLFQflD.....FGDWLDISI..REQDNQI...... 6 APAKLNLFLHILGRRDD---GYHEL...QTLFQflD.....HGDELHFEA..RQDGQVR...... 7 SPAKLNLFLYINGKFPN---GYHEL...QTLFQflD.....FGDWLDISI..REQDNQI...... 8 MRVKAPGRINIIGEHTDYNDGY-VL...PFAVN..-.....RFVFLTIED..SGKFVFH...... 9 -TFFSPGRINLIGEHTDYNGGR-VF...PAAIT..-.....LGTYGAARK..RDDKLLRfys11l 10 MKVKAPGRINIIGEHTDYNDGY-VL...PFAVN..-.....RYVFLSIEG..SERFIFH...... 11 ------FSVTVPGSTANLGPGFDSV...GMALS..-.....RYLKLTVFE..SDKWSFEa..... 12 APAKLNLDLRITGRREDGYHNIESI...FCLID..-.....LQDTVYLKP..RDDGKII...... 13 -YFFSPGRINLIGEHTDYNGGY-VF...PASIT..-.....IGTTGLARL..REDKKVKlys11l 14 ------FSVTVPGSTANLGPGFDSV...GMALS..-.....RYLKLTVFE..SDKWSFE...... 15 -YFFSPGRINLIGEHTDYNGGY-VF...PASIT..-.....IGTTGLARL..REDNKVKlys11l 16 -------KVYAPASSANMSVGFDVL...GAAVT..PvdgalLGDVVTVEA..AQTFSLNn..... 17 APAKLNLDLRITGRREDGYHNIESI...FCLID..-.....LQDTVYLKP..RDDGKII...... 18 -------KVYAPASSANMSVGFDVL...GAAVT..PvdgalLGDVVTVEA..AETFSLNn..... 19 ------MKILVPATSANLGPGFDCL...GLSLK..-.....LFNETQIQK..SGVFSIS...... 20 ------FKIKVPASSANIGPGYDVL...GVGLS..-.....LFLELDVTI..DSSQAQEtnd14y 21 -------KVYAPASIGNVSVGFDVL...GAAVS..PidgtlLGDCVSVEA..AETFSLQn..... 22 ---VSSVTVTVPATTANLGPGFDCI...GAALT..-.....LYNKVKFTR..LDAGGLIihv... 23 --AFAPGRINLIGEHTDYNGGY-VF...PAAIE..-.....LGTYGLASK..RNDNKIClys11t 24 -----PFTVRAPASSANLGPGFDSL...GLSVP..-.....LYTTLRVTP..QDKAEVVp..... 25 SPAKLNLFLYITGRRAN---GYHDL...QTLFQflD.....HGDELTITA..NNSGNIT...... 26 -FFFAPGRVNLIGEHTDYNGGH-VF...PCALT..-.....MGTYAAVAE..RNDGLVRmys11a 27 ------FKIKVPASSANIGPGYDVL...GVGLS..-.....LFLELDVTI..DSSQAQEtnd14y 28 -TFFAPGRINLIGEHTDYNGGH-VF...PCAIS..-.....LGTYAAVGT..NEDNAFRlys10r 29 --------VSVPATSANLGPGFDCL...GLSLN..-.....LRNRFFIEP..SSFHAVK...... 30 --FFSPGRINVIGEHTDYNGGH-VF...PAPIS..-.....LGVYGVYGP..RDDKKVRlys12i 31 APAKLNLFLQITGRRVD---GYHEL...QTVFRllD.....WGDTIHLRV..REDGQIH...... 32 --------VSVPATSANLGPGFDCL...GLSLN..-.....LRNRFFIEP..SNIHAVK...... 33 --YFSPGRINLIGEHTDYNGGH-VF...PASIT..-.....YGTQGVAAS..RKDNKVLvys11d 34 --EIMKVRVKAPCTSANLGVGFDVF...GLCLK..E.....PYDVIEVEA..IDDKEII...... 35 HTIQAPGRVNLIGEHTDYNDGF-VL...PCAID..-.....YQTVISCAP..RDDRKVRvma11q 36 HTIQAPGRVNLIGEHTDYNDGF-VL...PCAID..-.....YQTVISCAP..RDDRKVRvma11q 37 -------KIEVPATTTNFGSGFDTF...GLALS..-.....LTNTFSVDF..SDKYEVQ...... 38 -TFFSPGRINLIGEHTDYNGGN-VL...PVAIT..-.....LGTYGAARK..RDDKVLRffs11k 39 APAKINLFLEILGDRPD---GFHEL...VMVLQsiA.....LGDKITVRA..NGTDDIR...... 40 ------FQIKVPASSANIGPGFDVL...GMSLE..-.....EYMTLDVEV..STESGPCvlty.. 41 ------VVVYAPASIGNVSVGFDVL...GAAVS..PidgtlLGDRVKVEA..GAEAFTLkt.... 42 HTIQAPGRVNLIGEHTDYNDGF-VL...PCAID..-.....YQTVISCAP..RDDRKVRvma11q 43 -PVFVSVKTFAPATVANLGPGFDFL...GCAVD..G.....LGDHVTLRV..DPSVRAGevsise 44 -PVFVSVKTFAPATVANLGPGFDFL...GCAVD..G.....LGDHVTLRV..DPSVRAGevsise 45 ------MKVLVPATTTNLGAGFDVF...GLALD..-.....LFNEVEFSF..DTKETTI...... 46 -------RIYAPATIANFGPGFDVF...GMAIE..E.....PGDEVIVKE..SDSFEIE...... 47 -------RIYAPASSANISVGFDTL...GAAIS..PidgslLGDVVQIES..ISTGFELes.... 48 ----RKVTVTVPGSSANLGPGFDTL...GLALS..-.....VYDTVEVEI..IPSGLEVev.... 49 LFARSPGRVNLIGEHIDYE-GYSVL...PMAIR..-.....QDTIIAIRK..CEDQKQLria12t 50 LFARSPGRVNLIGEHIDYE-GYSVL...PMAIR..-.....QDTIIAIRK..CEDQKQLria12t 51 ----RKVTVTVPGSSANLGPGFDTL...GLALS..-.....VYDTVEVEI..IPSGLEVev.... 52 ------FTVSVPATTANIGPGFDCL...GAALG..-.....LYNHVTVTD..PTDPEVDlliea. 53 LFARSPGRVNLIGEHIDYE-GYSVL...PMAIR..-.....QDTIIAIRK..CEDQKQLria12t 54 LFARSPGRVNLIGEHIDYE-GYSVL...PMAIR..-.....QDTIIAIRK..CEDQKQLria12t 55 -YGESTGKIILIGEHAV-TFGEPAI...AVPFNagK.....IKVLIEALE..SGNYSSI...... 56 HLVQAPGRVNLIGEHTDYNDGF-VL...PCAIN..-.....YQTVVAAAK..REDFLVRlva11d 57 GYGESNGKIILIGEHAV-TFGEPAI...AIPFTsgK.....VKVLIESLE..KGNYSAI...... 58 -PAAHQARAFAPASVANVAVGFDLL...GYPMD..Q.....VGDTVTVRR..IDTPQVRiaa... 59 -YGESTGKIILMGEHAV-TFGQPAI...AIPFN..A.....GKIKVLIES..LDEGNYSsi.... 60 MIASAPGKIILFGEHAVVY-GRHAV...VSAIN..-.....LRCRVSVRK..SDRFLIR...... 61 ------MKIIVPATSANIGPGFDSV...GVAVT..-.....KYLQIEVSE..ERDEWLI...... 62 -LASAPAKVILFGEHSVVY-GKPAI...ASAIE..-.....LRTYVRAQF..NDSGNIKiea12g 63 APAKINLSLDVTRKRPDGYHEVEMI...MTTID..-.....LADRIELTE..LAEDEVR...... 64 ------MKIIVPATSANLGAGFDSI...GIAVN..-.....LYLTVEVLG..ESRDWKI...... 65 --VSAPGKLYIAGEYAVVETGHPAV...IAAVD..-.....QFVTVTVES..ARKVGSI...... 66 MIIETPSKVILFGEHAVVY-GYRAI...SMAID..-.....LTSTIEIKE..TQEDEIIlnl15n 67 --VTTPGKLFIAGEYAVVEPGHPAI...IVAVD..-.....QFVTVTVEE..TTDEGSI...... 68 -----SFKIKVPASSANIGPGFDVL...GIGLQ..-.....LYLTITVTI..DPSIDTSsdphha 69 ---CSRARARAYSSAANLGPGFDAL...AVALD..A.....YYDEVEVRV..CSGGNSVyvdev. 70 SYAKLNLYLDVLGKRSD---GYHEI...VGLFQtiS.....LHDTLTVEI..CDRGFYL...... 71 YWGKADETYIIPMNN--------SL...SVTLD..R.....FYTETKVTF..DPDFTED...... 72 -LASAPAKIILFGEHSVVY-GKPAI...ASAID..-.....LRTYVRAEF..NDSGNIKiea12g 73 FFARSPGRVNLIGDHIDYN-FFPVL...PMAIA..-.....NDVIAAVNV..NSTNEIIitn11f 74 MKVKAPGRINIIGEHTDYNDGY-VL...PFAVN..-.....RYVFLSIEG..SERFIFH...... 75 SPAKINLGLWVLGRLPS---GYHEI...LTLYQ..E.....IPFYDEIYI..REGVLRV...... 76 FFARSPGRVNLIGDHIDYN-YFPVL...PMAIE..-.....VDVVAAVST..NNNDMIVian12p 77 YWGKKDEALIIPMNN--------SI...SVTLE..K.....FYTETKVTF..NDQLTQD...... 78 -QVKAPGKLYIAGEYAVTEPGYKSI...LIAVN..-.....RFVTATIEA..SNKVEGSihskt. 79 FFARSPGRVNLIGDHIDYN-FFPVL...PMAIS..-.....ADVIVAVNV..NDEPEIVith15t 80 APAKINLGLSVLGVRENGYHDLHSL...MVPLT..-.....VGDELEIRP..AGALTLR...... 81 -------------------------...-----..-.....---------..-------...... 82 YWGKKNEELILPMNN--------SL...SLTLD..A.....FYTETEVIF..SDSYMVD...... 83 VPGKVNLYLAVGDRRED---GYHEL...TTVFH..A.....VSLVDEVTV..RNADVLSlel... 84 -KVKSPGRVNLIGEHTDYTYGY-VM...PMAIN..-.....LYTKIEAEK..HGEVILY...... 85 SPAKLNIFLQLLGKRED---GFHEI...VTRYQavS.....FGDQLSLSV..SSRDSFQ...... 86 ---------VVAASSANLGPGFDSI...GLALS..-.....LCDEIVVET..TDSGLVVvv.... 87 YWGKKKEKEMVPATS--------SI...SLTLE..N.....MYTETTLSP..LPANVTA...... 88 --WAAPGRVNLIGEHTDYNDGF-VM...PFALP..-.....HQAVAAVSR..RDDGILRlhs10a 89 -------------------------...--AID..K.....PFDEVVVEE..FNEFEII...... 90 -QGESSGKIILMGEHAVVY-GEPAI...AFPFY..A.....TKVTAFLEE..LDAMDDQl..... 91 AHAKVNMHLWVGARRAD---GLHSI...ESVMQ..R.....ITLADSLSL..SRLDIPG...... 92 VPAKVNVQLAVGAARPD---GFHDLanvFLAVS..-.....LYDEVTATP..AADGLRVtc.... 93 YWGKENQAKMIPSTS--------SI...SLTLE..N.....MFTTTSVSF..LPDTATS...... 94 SPAKLNLFLKIWGKRFD---NFHEL...TTLYQ..A.....IDFGDTLSL..KNSMKDS...... 95 SPAKLNLFLQILGRRED---DFHEI...VTRYQaiA.....FGDQLSLSI..SSRDSLQ...... 96 YWGKADEALIIPMNN--------SL...SVTLD..R.....FYTETRVTF..DETLTED...... 97 -IGRAHAKAILLGEHAVVY-GAPAL...ALPIP..Q.....LTVTASVGW..SSEASDS...... 98 -LGQATGKIILMGEHAVVY-GEPAI...AFPFQ..A.....TEITAVFTP..AKTMQIDcay... 99 YWGKRDERLILPCTT--------SL...SMTLD..V.....FPTTTEVRL..DPAAEHD...... 100 -YAKANIFLKLTGFDSRKYHLLESR...FILLK..D.....VFDELELVD..KESDSKK...... 101 -------------------------...----Gi.E.....LWTEARVRV..TGDGEVR...... 102 -------------------------...---L-..D.....LKVYAKVKL..IDDGKNK...... 103 ----------VAASSANLGPGFDSV...GLALS..-.....LYDEIIVET..TDSGLTVtv.... 104 --------IDLNGERGRLDGGV---...GITLN..E.....PELVVGLEA..SDDMGVE...... 105 ---SAPGKVIIFGEHSAVY-NKPAV...AASVS..A.....LRTYLLISE..SSAPDTIeld44s 106 ---SAPGKVIIFGEHSAVY-NKPAV...AASVS..A.....LRTYLLISE..SSAPDTIeld44s 107 -TGRAHAKAILLGEHAVVY-GTPAL...AMPIP..Q.....LAVTASAGW..SGRSAES...... 108 -RASAPGKVIIVGEHFVVRGSL-AI...VAAIG..-.....RRLRVTVRS..GGKGIVL...... 109 -------------------------...---FGi.G.....LRVEAEAEL..IDSGVEC...... 110 -KARAPGKIILAGEHAVVH-GSTAV...AAAID..-.....LYTYVTLRF..PLPSAENndr48l 111 YWGKKDVFLNIPATS--------SL...AVSVD..K.....FYSISELEL..SNRDEII...... 112 -------------------HDFESI...FILVE..N.....IYDDIEITK..IEKNIDD...... 113 -KARAPGKIILAGEHAVVH-GSTAV...AAAID..-.....LYTYVTLRFpl-PSNNDRltl45l 114 -------LIDLNGSIGRVDGGI---...GLALE..E.....PNIKIEGKE..SDDISIEfdkkl. 115 -------------------HGCRLL...AVALT..A.....HGALRLAEA..PEGVTVR...... 116 -------------------------...-----..K.....LKDIISVKS..ALSFS--...... 117 --------IDLNGSIGRVDGGV---...GLALE..E.....PHIEIKAKE..SETFVLK...... 118 --------LGMIDPTGSLGRRFGSI...GVALE..-.....GGYEIKVTP..AGSLTIE...... 119 --------IDLNAEIGRVDGGV---...GITLE..S.....PSLEISASE..ADTVEVV...... 120 --------AKAYAAGTVLNALPTGI...GSAFGi.E.....MHTIVKLRP..SDELKVF...... 121 -----RLHLGIIDPTGSLGRKFGSI...GVALE..-.....GGYDIKVTP..AGSLTIE...... 122 ---------------GDMGRLFGTL...GFAIE..Y.....PYLEVEIET..SEKDKA-...... 50 60 70 80 90 | | | | | 1 ..IEVDDKNIPTDPDK........NVAGIVAKKMIDDF...NIG........KGVKITIKKGVKA 2 ..LLTPVEGVEH--ED........NLIVRAARLLMKTA...ADSgrlptg..SGANISIDKRLPM 3 ..LLTPVNGVEN--ED........NLIVRAARLLMKVA...SESgrlpag..SGADISIEKRLPM 4 ..LHTEIAGVPH--DS........NLIVRAARGLQEAS...GSP........QGVDIWLDKRLPM 5 ..VLTPEIPNLKT-EN........NLIYRAAKLLQEKA...NIQ........LGANIHLDKILPM 6 ..LHTEIAGVPH--DS........NLIVRAARGLQEAS...GSP........QGVDIWLDKRLPM 7 ..VLTPEIPNLKT-EN........NLIYRAAKLLQEKA...NIQ........LGANIHLDKILPM 8 ..SENMNETVEMEKIEkl......NRWTDYISGVIKAF...EKRgykv....SPVKISVSSNLPM 9 giIEISLDHLIFN-KK........DSWTNYAKGVIKYL...QEAghsid...TGMDVYVFGNIPN 10 ..SENVNETVEMEKIEkl......NKWTDYISGVIASF...EKRgyrv....SPVKISVSSNLPI 11 ..ETETVAGIPAG-TD........NLIYQVAKRTADLY...GKEm.......PPVHVKVWSDIPL 12 ..LHNPVDGMPQ--EA........DLSYRAASLLQKYA...RTP........TGVEIWLDKKIPT 13 gvIEFDLDEVEKK-DG........ELWSNYVKGMIVML...KGAgyeid...KGFELLIKGEIPT 14 ..AETETVAGIRG-TD........NLIYQVAKRTADLY...GKEm.......PPVHVKVWSDIPL 15 gvIEFDLDDVENK-DG........ELWSNYVKGMIVML...KGAgyeid...KGFELLIKGEIPT 16 ..LGRFADKLPSEPRE........NIVYQCWERFCQEL...GKQ........IPVAMTLEKNMPI 17 ..LHNPVDGMPQ--EV........DLSYRAASLLQKYA...RNP........AGVEIWLDKKIPT 18 ..LGRFADKLPSEPRE........NIVYQCWERFCQEL...GKQ........IPVAMTLEKNMPI 19 ..IGGEGSDNIFLKKN........NIFVNIFYEIYEKL...SGKk.......DNFRFIFQNNIPL 20 tkESEGYSTVPLRSDA........NLITRTALYVLRCN...NIRnfp.....SGTKVHVSNPIPL 21 ..AGRFVSKLPAEPKE........NIVYQCWERFCQEI...GRE........VPVAMRLEKNMPI 22 ..TGKEAEGVNTD-ES........NLLYQAFVKLYQHIe..QIP........PSVKIEIDLGVPL 23 gtIEFSLDELQFD-TT........HSWANYPKGMVKFL...KESgyqid...SGFNILIEGNIPN 24 ..LGTELADTPAD-ES........NYVYRAMTLAAKRA...GRTl.......PPARVEIETEVPL 25 ..LSPALADVAL--ED........NLIYKAAMALKNAA...QSP........LGADIQLHKVLPM 26 giKECSLDDIRYQ-KE........DDWANYPKGVIYEF...QQRgyavp...HGFDIVFSGNIPN 27 tkESEGYSTVPLRSDA........NLITRTALYVLRCNir.NFP........SGTKVHVSNPIPL 28 laLLTSIFGSFQD-KR........GLWTDYFQGMARVM...KTAganft...HGLNVYINGNLPD 29 ..LVGEGEGIPKFLTN........NIFTKVFYEILKKH...GND........GSFKFLLHNKVPI 30 veFDIDDTNVEKD-ED........RFWANYFKGMITYL...REKydgid...HGFNLYIEANLPS 31 ..RIGESVTGVVE-AD........DLVVRAAYLLKYAT...NVH........LGADIFVEKRIPV 32 ..LVGEGEGIPKFLTN........NIFTKVFYEILKKH...GND........GSFKFLLHNKVPI 33 gvISFTLNELEYD-KQ........AGWANYVKGMILKL...KEAgytfd...HGFELLVEGTIPN 34 ..IEVDDKNIPTDPDK........NVAGIVAKKMIDDF...NIG........KGVKITIKKGVKA 35 ldEFSLDAPIVAH-EN........YQWANYVRGVVKHL...QLRnnsf....GGVDMVISGNVPQ 36 ldEFSLDAPIVAH-EN........YQWANYVRGVVKHL...QLRnnsf....GGVDMVISGNVPQ 37 ..IEGYSSGIPKD-QK........NLFIKVYKKTCQSI...GKKp.......KPLKLIQENRVPP 38 giIEVPLENLRFE-KE........HNWTNYPKGVLHFL...QEAghtid...SGMDIYIYGNIPN 39 ..LSCGDSPLAND-AT........NLAYRAAQLMINNF...PQAhdny....GGVDITLTKHIPM 40 ..EGDGKEHVSLDVQK........NMITQTSLYVLRCN...NIStfp.....YATKIHVINPIPL 41 ..AGRFVDKLPANPQE........NIVYDCWQVFAREL...EKKsvvl....KPLTMTLEKNMPI 42 ldEFSLDAPIVAH-EN........YQWANYVRGVVKHL...QLRnnsf....GGVDMVDHGNVPQ 43 ..ITGTTTKLSTNPLR........NCAGIAAIATMKML...GIRs.......VGLSLDLHKGLPL 44 ..ITGTTTKLSTNPLR........NCAGIAAIATMKML...GIRs.......VGLSLDLHKGLPL 45 ..ESTGKYASDLK-DH........NLFFEVLRFFERKT...GYRv.......PPVRIKQTCNIPV 46 ..VEGY--DVPRD-EN........NVAVISAKALFKMV...GEE........GGVKIRLKKGVRP 47 ..AGYFVRKLPKEPQK........NIVYQAYVLFSEQL...KLRganv....KPLRLTLEKNMPI 48 ..FGEGQGEVPLD-GS........HLVVKAIRAGLKAA...DAEv.......PGLRVVCHNNIPQ 49 mcTYPADPDQEIDLKN........HKWGHYFICAYKGF...HEYaks11gspVGLDVLVDGIVPT 50 mcTYPADPDQEIDLKN........HKWGHYFICAYKGF...HEYaks11gspVGLDVLVDGIVPT 51 ..FGEGQGEVPLD-GS........HLVVKAIRAGLKAA...DAEv.......PGLRVVCHNNIPQ 52 ..RGRDGEKISTT-KD........NLLYQAIAYFYQQT...GQAi.......PPLKLEIDLEIPL 53 mcTYPADPDQEIDLKN........HKWGHYFICAYKGF...HEYaks11gspVGLDVLVDGIVPT 54 mcTYPADPDQEIDLKN........HKWGHYFICAYKGF...HEYaks11gspVGLDVLVDGIVPT 55 ..KSDVYDGMLYD-AP........DHLKSLVNRFVELN...NIT........EPLAVTIQTNLPP 56 tdEFDLREEIAFQ-PK........KMWSNYIRGVIKCL...IERgfef....NGADIVVSGNVPQ 57 ..QSDVYDGPLYD-AP........EHLKSLIGHFVENK...KVE........EPLLIKIQANLPP 58 ..IRGIAQPLPLQTER........NTAGAALLSMHRDL...ALP........FGFELEIDKGIPL 59 ..TSDVYDGMLYD-AP........EHLKSIINRFVEKS...GVK........EPLSVKIQTNLPP 60 ..SSLGESGLDYQ-RH........PYVVQAVKRFGELR...NIP........-GAEIEIESEIPI 61 ..EHQIGKWIPHD-ER........NLLLTIALQIVPDL...Q--........-PRRLKMTSDVPL 62 liVSFSEDKIYFETDYgkaaevl.SYVRYAIELALEES...DKR........VGIDVSITSQIPV 63 ..VSSHNRFVPDD-QR........NLAYQAAKLIKDRY...NVK........KGVSIMITKVIPV 64 ..DHDLGENIPTD-ER........NLLLTTLSAVLEDK...NVAls......AKFHLKMTSEVPL 65 ..QSAQYSGMPVRWTRrng14npfHYILAAIRLTEKYA...QEKnill....SFYDLKVTSELDS 66 lnEIKNINPNNFG-DF........KYCLCAIKNTLDYL...NIEpk......TGFKINISSKIPI 67 ..QSAQYSSLPIRWTRrng14npfHYVLAAIHLTEKYA...QEQnkel....SFYHLKVTSELDS 68 llSYEGDGKVPFESNE........NLITQTALYVMRCN...GIKdfp.....RGTHIHVNNPIPL 69 ..EGKFSSGVLQ--GP........NTAAEAVRGLLNME...GVE........AEVGIRVYKGVPP 70 ..ESSVALP-----SD........NTIKRAWEMFRKNT...GKE........FGLKVTLKKEIPV 71 ..CLILNGNEVNAKEK........EKIQNYMNIVRDLA...GNR........LHARIESENYVPT 72 liVSFSEDKIYFETD-ygkaaevlSYVRHAIELVLEEA...DKR........TGVSVSITSQIPV 73 lkEVIALRNSQIDQEH........HSWANYFKCALIVA...KQYlee9vtslKGMKLTFNGNVPT 74 ..SENVNETVEMEKIEkl......NKWTDYISGVIASF...EKRgyrv....SPVKISVSSNLPI 75 ..ETNI--GIPQ--EE........NLVYKGLREFERIT...GIE........INYSIFIQKNIPP 76 keTVSLAEEFTIDREH........HTWANYFKCGLIVA...SKFlqe9mtklKGMNITFSGTVPT 77 ..QFWLNGEKVSGKEL........EKISKYMDIVRNRA...GID........WYAEIESDNFVPT 78 ..--LHYEPVKFDRNEdri14kqlKYVVTAIEVFEQYV...RSCnmnl....KHFHLTIDSNLAD 79 ipLTNNNDGFEIDSQH........HSWANYFKCALIVA...NNYlte10gqlKGMKLTFDGNVPT 80 ..VEG--ADLPTD-ER........NLVYRAARAYLDAA...GAA........GGADLVLHKRLPL 81 ..-----------HED........NLIVRAARLLMKTA...ADSgrlptg..SGANISIDKRLPM 82 ..EFYLDGTLQDEKAT........KKVSQFLDLFRKEA...GLS........LKASVISQNFVPT 83 ..VGEGADQLPTD-ER........NLAWQAAELMAEHV...GRA........PDVSIMIDKSIPV 84 ..SEHFGEERKFSLNDlrke....NSWIDYVKGIFWVL...KESdyev....GGIKGRVSGNLPL 85 ..I---INDCQLEISN........NSIWKSTALFRQYT...GIT........DPVSWRVVKHIPI 86 ..DGEGADQVPMG-PE........HLVVRAVRRGLQAV...GVSa.......AGLVVRCRNAIPH 87 ..DEFYINGQLQNEVE........HAKMSKIIDRYRPA...GEG........-FVRIDTQNNMPT 88 dpVELRVADLAPG-SD........KSWTAYPSGVLWAL...REAghel....TGADVHLASTVPS 89 ..SSGY--PVPNG-ED........NIALFSAKTLFKML...NIE........GGLRIKLKKGIRP 90 ..VSSYYSGNLAE-AP........HALKNIKKLFIHLK...KQHdiq.....KNLQLTIESTIPA 91 ..RCEVCSPYMALPRE........NTLTRAYARFCQVT...GVH........DGVRVRVVKRIPA 92 ..EGPDAGQVPLD-RT........NLAARAAEALAARY...GRA........PDVHLHIAKDIPV 93 ..DQFYINGVLQNDEE........HTKISTIIDQFRQP...GQA........-FVKMETQNNMPT 94 ..LSSNVNELLS--PS........NLIWKSLEIFRRET...QIH........QPVSWHLNKSIPL 95 ..VI---NACHLETPS........NSIWKSVALFRRYT...GIT........TPVSWRVVKQIPV 96 ..QLILNGEAVNAKES........AKIQRYMEMIRKEA...GIS........EHALIESENFVPT 97 ..AGGLSYTMTGTPSR........ALVTQASDGLHRLT...AEFmar9vtnaPHLDVILDGAIPH 98 ..FTGLLEDVPQ--EL........ANIKEVVQQTLHFL...KEDt.......FKGTLTLTSTIPA 99 ..TAALNGEVATGETL........RRISAFLSLVREVA...GSD........QRAVVDTRNTVPT 100 ..EFEIISNFKC--EN........NIIQKAYLLLSRRY...NNElkelf...SKKSLKLTKNIPV 101 ..GKIVVKGEEFK-DY........RLVNSVISVLREVT...GEP........FGVRFEIHSDIPV 102 ..IEGKVLDNPNI-KP........NLIVRCVKNTLDYF...GLN........YSAYVETKTEIPI 103 ..DGEGGDQVPLG-PE........HLVVRAVQHGLQAA...GVSa.......AGLAVRCRNAIPH 104 ..FTSHAEGKLREEYR........SKIMEAARRTLKHI...GSD........EKFHFTVRSMFPA 105 qeLVSLLDPLLAQLSEsfhy....HAAFCFLYMFVCLC...PHA........KNIKFSLKSTLPI 106 qeLVSLLDPLLAQLSEsfhy....HAAFCFLYMFVCLC...PHA........KNIKFSLKSTLPI 107 ..RGGPTFTMTGSASR........AVTAQALDGLRRLTasv---kah9vtdgQHLDVSLDGAIPP 108 ..ESSMLGRHSAPLPGqgaaakvsPVLEPYIAVLRSLA...ARGysv.....VPHTILVESGIPP 109 ..ISREGA------DT........SLMELCTRMVIEHY...GVD........AGVRVVTSSDLPV 110 ksIAVLVEEQNLP-KE........KMWLSSGISTFLWL...YTRiigf....NPATVVINSELPY 111 ..LNS--KPVILKNRE........KVFFDYARKILNEP...NVR........--FKIKSKNNFPT 112 ..VHYYNETNEIYVYS........RLVHKTLEWIRHTY...HIK........NHYRINIKKRIPI 113 ksIAVLVEEQNLP-KE........KMWLSSGISTFLWL...YTRiigf....NPATVVINSELPY 114 ..IEKYGEDYIKS-VR........DRVYNTAIKVLDVI...GGE........-GVDLKILSLFPA 115 ..AFGTETRAEH--AS........SHPDPLVRAALGYF...GID........RGVHLTVESDVAP 116 ..---LKGDFDCPLEE........NSLFKALQILKNFL...KSKnfs10kslDTLAIEVEKNIPT 117 ..GEPI--------NR........ERFEIAAAKMAEYC...GR-........-GAEIEVVSDYDA 118 ..ADEE--------DR........KVIERVVKELNLKY...ETG........LDYYIEVRRSIPR 119 ..GSSL----------........-LAGRMLKAAKAVI...PEG........KGIKIHIKRDLPD 120 ..------------VN........GVERRSIVAERILN...SMD........VTAEVIVESEIPG 121 ..ADKE--------DR........EVIEKIVKELNLEY...ETG........LDYYIEVRKSIPR 122 ..------------ND........KDALRFLERLREKY...EFP........-PVKIEIKHYIPK 100 110 120 130 | | | | 1 GS....GLGSSAASSAGTAYAI........NELFKL........NLDKLKLV...DYASYGELAS 2 GG....GLGGGSSNAATVLVAL........NHLWQC........GLSMDELA...EMGLTLGADV 3 GG....GLGGGSSNAATVLVAL........NHLWQC........GLSIDELA...TLGLTLGADV 4 GG....GIGGGSSDAATTLLAL........NHLWQL........GWDEDRIA...ALGLRLGADV 5 GG....GVGGGSSNAATALVSL........NYLWQA........NLSIDELA...KLGLTLGADV 6 GG....GIGGGSSDAATTLLAL........NHLWQL........GWDEDRIA...ALGLRLGADV 7 GG....GVGGGSSNAATALVSL........NYLWQA........NLSIDELA...KLGLTLGADV 8 GA....GLSSSAALEMATAYAI........SEHFGF........HLPKLELV...KIAREAEVEF 9 GS....GLSSSSSLELLIGIMA........EELFDL........KLDRLDLV...KIGKRTENDF 10 GA....GLSSSAALEVATAYAI........SEYFGF........NVPKLELV...KIAREAEVEF 11 AR....GLGSSAAAIVAAIELA........DELCGL........KLSEADKL...HLASLEEGHP 12 GA....GLGGGSSDAATVLLVL........NRWWQC........GLTQRQLI...DSGAALGADV 13 AS....GLSSSASLELLVGVVL........DDLFNL........NVPRLELV...QLGQKTENDY 14 AR....GLGSSAAAIVAAIELA........DELCGL........KLSEADKL...HLASLEEGHP 15 AS....GLSSSASLELLVGVVL........DDLFKL........SVPRLELV...QLGQKTENDY 16 GS....GLGSSACSVVAALMAM........NEHCGK........PLNDTRLL...ALMGELEGRI 17 GA....GLGGGSSDAATVLLVL........NRWWQC........GLTQRQLI...DSGAALGADV 18 GS....GLGSSACSVVAALMAM........NEHCGK........PLNDTRLL...ALMGELEGRI 19 SR....GLGSSSAVIVGAIASA........YYMSGF........KVEKECIL...DEALIYENHP 20 GR....GLGSSGAAVVAGVILG........NEVAQL........GFSKQRML...DYCLMIERHP 21 GS....GLGSSACSVVAGLMAM........NEFCDR........PLDKTTLL...GLMGELEGRI 22 AR....GLGSSATAIVGGLVAA........NQLAGE........PLSQLQVM...ELAIAMEGHP 23 GA....SLSSSASIEILMGWLL........KALFNL........EVERLELI...ELGRKVENQF 24 AR....GLGSSAAALVAGVVAG........NELLGR........PLDDETVL...DVTAREEGHP 25 GG....GIGGGSSNAATTLVAL........NYLWQT........GLSDDQLA...EIGLALGADV 26 GA....GLSSSASIELLMGVVL........QSYFHP........EVDALELV...KMAQHAENHF 27 GR....GLGSSGAAVVAGVILG........NEVAQL........GFSKQRML...DYCLMIERHP 28 GA....GLSSSASLEMLVGTIL........NSLFDG........GFEPLELV...QFGVKVENDY 29 TR....GMGSSSAMIVGAVASA........FAFLGF........DFDRENIV...NTALIYENHP 30 GS....GLSSSAAIEMLMGIIL........KDEFNL........DVDRVSLA...KMGQRTENEF 31 GG....GFGGGSSDAATVLLVL........NALWHT........RLDVAVLA...ALGLRLGADV 32 TR....GMGSSSAMIVGAVASA........FAFLGF........AFDRENIL...NTALIYENHP 33 GA....GLSSSASLELLVGVVL........EDLFDL........AIDRLALV...QTGKKVENEF 34 GS....GLGSSAASSAGTAYAI........NELFKL........NLDKLKLV...DYASYGELAS 35 GA....GLSSSASLEVAVGTVL........QQLYHL........PLDGAQIA...LNGQEAENQF 36 GA....GLSSSASLEVAVGTVL........QQLYHL........PLDGAQIA...LNGQEAENQF 37 AR....GLGSSATAIVGGIEAA........LALHKV........ELPLKEKL...KIAFEFEKHP 38 GS....GLSSSSSLELLIGVIV........EKLYDI........KLERLDLV...KIGKQTENDF 39 AA....GLAGGSADAAAVLVGL........DLLWNL........GLTRPELE...QLAAQLGSDI 40 GR....GMGSSGSAAIAGVMLA........NEIAKL........GLSKLQMM...DYVLMIERHP 41 GS....GLGSSACSIVAALDAL........NQFHAS........PLDETELL...ALMGEMEGKI 42 GA....GLSSSASLEVAVGTVL........QQLYHL........PLDGAQIA...LNGQEAENQF 43 GS....GLGSSAASAAAAAVAV........NEIFGR........KLGSDQLV...LAGLESEAKV 44 GS....GLGSSAASAAAAAVAV........NEIFGR........KLGSDQLV...LAGLESEAKV 45 SS....GLGSSAAVIVAALHIA........NEGTGR........NLSREDLM...KLAVELEGHP 46 KS....GLGSSGASSVAGALAA........ARVLGV........DNDELIIM...-AALEGEKAA 47 GS....GLGSSACSIVAALVAL........NQFHNE........PFSKMELL...EMMGELEGRI 48 SR....GLGSSAAAAVAGVAAA........NGLADF........PLTQEQIV...QLSSAFEGHP 49 GS....GLSSSAAFVCSATIAI........MAVFGH........NFEKKELA...QLTCECERHI 50 GS....GLSSSAAFVCSATIAI........MAVFGH........NFEKKELA...QLTCECERHI 51 SR....GLGSSAAAAVAGVAAA........NGLADF........PLTQEQIV...QLSSAFEGHP 52 AR....GLGSSATAIVGGLLAA........NQAAGN........PCTTSEIL...QMAIAMEGHP 53 GS....GLSSSAAFVCSATIAI........MAVFGH........NFEKKELA...QLTCECERHI 54 GS....GLSSSAAFVCSATIAI........MAVFGH........NFEKKELA...QLTCECERHI 55 SR....GLGSSAAVAVAFVRAS........YDFLGK........SLTKEELI...EKANWAEQIA 56 GA....GLSSSAALEVVIGQTF........KELYQL........KISQAEIA...LNGQQAENQF 57 SR....GLGSSAAVAVAFIRAS........YDYLGL........PLTDKELL...ENADWAERIA 58 SS....GMGGSAASCVAALLAA........NALLEE........PLRREHLY...RYALDGEAVA 59 SR....GLGSSAAVAVAFVRAS........YDFMDQ........PLDDKTLI...KEANWAEQIA 60 GS....GLGSSAAVIVATIAAL........NAEFDG........DMDKEAIF...QMAKQVEIDV 61 AR....GLGSSSSVIVAGIELA........NQLGQL........NLSDHEKL...QLATKIEGHP 62 GA....GLGSSAAVAVATIGAV........SRLLGL........ELSKEEIA...KLGHKVELLV 63 AA....GLAGGSSDAAATLRGL........NRLWNL........NLSAETLA...ELGAEIGSDV 64 AR....GLGSSSSVIIAGIELA........NQLAKL........NLTSDEKL...KLACEIEGHP 65 SNgrkyGLGSSGAVTVATVKAL........NVFYAL........NLSQLEIF...KIAALANLAV 66 SC....GLGSSASITIGTIKAV........SGFYNK........ELKDDEIA...KLGYMVEKEI 67 SNgrkyGLGSSGAVTVGTVKAL........NIFYDL........GLENEEIF...KLSALAHLAV 68 GR....GLGSSASAIVAGVYLG........NEIGNL........KLDKYRLL...DYCLMIERHP 69 GR....GLGSSGASAAAAVAAV........SHALAL........EVPVDRLV...FYAGLGERAA 70 GS....GLGGGSSNAAAVLRYL........GEVFKI........PL--EDLL...NIAAQVGSDV 71 AA....GLASSASAYAALAAAC........NEALSL........NLSDTDLS...RLARRGSGSA 72 GA....GLGSSAAVAVATIGAV........SKLLDL........ELSKEEIA...KMGHKVELLV 73 GG....GLSSSAAFCVASTLAI........IRANGIt.......DLTKQDLT...RITVVSEHYV 74 GA....GLSSSAALEVATAYAI........SEYFGF........NVPKLELV...---------- 75 GA....GLGGGSSNLAVVLKKV........NELLGS........PLSEEELR...ELVGSISADA 76 GG....GLSSSAAFCVASTLAV........LYANGVe.......DISKADLT...RITVVSEHYL 77 AA....GLASSASAYAALAAAC........NQALDL........QLSDKDLS...RLARIGSGSA 78 NSgqkyGLGSSAAVLVSVVKAL........NEFYGL........ELSNLYIY...KLAVIANMKL 79 GG....GLSSSAAFCVASTLAI........LHANGVk.......DITKADLT...RITVVCEHYV 80 AS....GLGGGSSDAASTLLAL........AELYPAp.......DHRPVDLP...ALALTLGADV 81 GG....GLGGGSSNAATVLVAL........NHLWQC........GLSMDELA...EMGLTLGADV 82 AA....GLASSASGLAALAGAC........NTALKL........GLDDLSLS...RFARRGSGSA 83 AG....GMAGGSADAAAVLVAM........NSLWEL........NVPRRDLR...MLAARLGSDV 84 GA....GLSSSASFEVGILETL........DKLYNL........KLDSLSKV...LLAKKAENEF 85 GS....GLAGGSSNAATALFAL........NQMFQT........GLSDEELR...SLAEKVGMDT 86 SR....GLGSSAAAVVGGLAVV........NGFVAQidst....PLSNAQLI...QLASEFEGHP 87 AA....GLSSSSSGLSALVKAC........NAYFKL........GLDRSQLA...QEAKFASGSS 88 GA....GLSSSAALEVVLALAM........NDLYAL........GLRGWQLA...RLCQRAENVY 89 KS....GLGSSGASAVAGALGA........AKLLGV........SNDELILK...AAMKGEEKAS 90 ER....GMGSSAAVATAVTRAF........YDYLAF........PLSREILL...ENVQLSEKIA 91 GS....GLGGGSADAAALLCGL........DTLFGT........TLSARVLR...EVAYSVGSDV 92 AG....GMAGGSADGAGALLAC........DALWGT........GASREELL...EICAGLGSDV 93 AA....GLSSSSSGLSALVKAC........DQLFDT........QLDQKALA...QKAKFASGSS 94 QS....GLGGGSSNAATALYAL........NEHFQT........HIPITTLQ...LWAREIGSDV 95 GA....GLAGGSSNAATALFAL........NQIFKT........GLSDEEMR...SLAEQLGVDT 96 AA....GLASSASAYAALAGAC........NEALQL........GLSDKDLS...RLARRGSGSA 97 GR....GLGSSAAGSRAIALAL........ADLFGH........ELAEHTAY...ELVQTAENMA 98 ER....GMGSSAATAVAIVRSL........FDYFDY........AYTYQELF...ELVSLSEKIA 99 GA....GLASSASGFAALAVAA........AAAYGL........ELDDRGLS...RLARRGSGSA 100 CA....GLGGGSSDCASFLLLI........NETLNL........KLNLQELI...NLSIQLGSDI 101 GK....GLKSSSAAANSLTKAL........VEALRL........NIDDLSIV...KLGVEAAKRA 102 KS....GLSSSSATSNAVVLAT........FDALGE........KIDDELIL...NLGIKSSFDE 103 SR....GLGSSAAAVVGGLAAV........NGLVVQtdss....PSSDAELI...QLASEFEGHP 104 HS....GLGSGTQLSLATARLV........AEYHGM........KFTARELA...HIVGRGGTSG 105 GA....GLGSSASISVSLALAM........AYLGGLigs10klsENDKHIVN...QWAFIGEKCI 106 GA....GLGSSASISVSLALAM........AYLGGLigs10klsENDKHIVN...QWAFIGEKCI 107 GR....GLGSSAANARAIILAL........ADLFGR........ELTEGEVF...DLVQEAENLT 108 RA....GLGSSAASMVAYALSY........SAMHGD........PLSAEDLY...SVAMEGEKIA 109 AS....GLSSSSAASNATVMAV........SSLLSDefglq...PMEDFEML...NMAVDASLQA 110 GS....GLGSSAALCVALTAALlas11trgNGWSSL........DETNLELLn..KWAFEGEKII 111 AA....GLASSSSGFASIAACI........LKYFN-........KYSCNSAS...NLARVGSASA 112 GA....GLGGGSSNAAAIMKYI........LEFEG-........-IKEINYK...DVVNKLGADI 113 GS....GLGSSAALCVALTAALlas11trgNGWSSL........DETNLELLn..KWAFEGEKII 114 HS....GLGSGTQLSLAVGKLI........SKIYNK........EMNAYNIA...KITGRGGTSG 115 GS....GLGGSGAFLVALATAL........SHLTGD........PLTPAAAA...RAAFRIERAL 116 QA....GLGGGSTDAGGLLYHL........NQIFDW........RLSLEELY...SMGSLVGADT 117 HV....GLGSGTQISLAVGRAF........SELYGL........NLTTRQIA...EIMGRGGTSG 118 HI....GLGSTTQLTLAIASAI........LRIAKK........EVPIEDVA...---------- 119 HV....GLGSGTQAALSVAAAI........NEIYGL........GKSVRELA...VAVGRGGTSG 120 GS....GLGSSSAFVNALICAV........KKMKGE........ELNAFEIL...RSNARFSLEA 121 HI....GLGSTTQLTLAIASAI........LRIAKK........DIPIEEVAfslKRARESGAGL 122 WV....GLGFHTTLALTLGLGI........NRIYNL........GLSLEDIA...LTVRRGLITA 140 150 160 170 18 | | | | 1 O........DKVYGIT.ISGSGPS........IIAFPKEEFID.EVENILR.DYYENTIRTEVGK 2 P........VFVRGHA.AFAEGVG........EILTPVDPPEK.WYLVAHP.GVSIPTPVIFKDP 3 P........VFVRGHA.AFAEGVG........EILTPVNPPEK.WYLVAHP.GVSIPTPVIFKDP 4 P........VFTRGRA.AFAEGVG........EKLTPVDIPEP.WYLVVVP.QVLVSTAEIFSDP 5 P........IFVHGHA.AFAEGVG........EKITYCEPAEK.WFVILKP.DDSISTAVIFQDP 6 P........VFTRGRA.AFAEGVG........EKLTPVDIPEP.WYLVVVP.QVLVSTAEIFSDP 7 P........IFVHGHA.AFAEGVG........EKITYCEPAEK.WFVILKP.DDSISTAVIFQDP 8 V........GVRCGIM.DQFTSAFgkkdha..IFLDTMTLEYE.YVPLKLE.GYEINLVDSNVKH 9 I........GVNSGIM.DQFAIGMgaekka..IYLDTKTLEYD.LVPLDLG.DNVIVIMNTNKRR 10 V........GVRCGIM.DQFTAVFgkkdha..IFLDTMTLEYE.YVPLKLE.GYEINLVDSNVKH 11 Dnag54kefPYADAVK.ASAVSNI........LIAAIMSKDWP.LVGKIMKkDMFHQPYRAMLVP 12 P........FFIFGKN.AFARGIG........DRLDEMDIPKQ.WYVIVKP.PVHVSTAKIFTHE 13 I........GVNSGIL.DQFAIGFgevkka..ILLDCNTLKYE.MVPVELR.DYDIVIMNTNKPR 14 Dnag54kefPYADAVK.ASAVSNI........LIAAIMSKDWP.LVGKIMKkDMFHQPYRAMLVP 15 I........GVNSGIL.DQFAIGFgevkka..ILLDCNTLKYE.MVPVELR.DYDIVIMNTNKPR 16 Sgsi59aqyRRQDCIA.HGRHLAG........FIHACYSRQPE.LAAKLMK.DVIAEPYRERLLP 17 P........FFIFGKN.AFARGIG........DRLDEMDIPKQ.WYVIVKP.PVHVSTAKIFTHE 18 Sgsi60aqyRRQDCIA.HGRHLAG........FIHACYSRQPE.LAAKLMK.DVIAEPYRERLLP 19 Dnia55knlSFNDAVF.NLSHASF........LTACFLEKKYE.FLKFASQ.DKLHEINRMKNLP 20 Dnit90kayPTQDLVF.NLQRLAVlt......TALTMDPPNAD.LIYPAMQ.DRVHQPYRKTLIP 21 Sgsv60aqyRRQDCIS.HGRYLAG........FIHACHTRQPQ.LAAKLMQ.DVIAEPYRTRLLP 22 Dnvv55tefSRADAIF.NTAHLGL........LLRGLATGKGE.WLKTALQ.DKLHQPYRKALIP 23 I........GVNSGIM.DQFIVGMgrkdqa..ILLDTATLEYH.YVPTEFG.DYVISIMNTNKRR 24 Dnva55reySRADTVH.ALSHAAL........LAAALAQGRLD.LLRHAMQ.DYVHQVWRAPLVP 25 P........VFTRGFA.AFAEGVG........EELSAVEPEEK.WYLVVRP.AVSIATKDIFTHP 26 I........GVNCGIM.DQFAIGMgkkhha..MLLNCDTLDYE.YSKLNVS.GLALVIANTNKKR 27 Dnit90kayPTQDLVF.NLQRLAVlt......TALTMDPPNAD.LIYPAMQ.DRVHQPYRKTLIP 28 I........GVNSGVM.DQFAIEMgranqa..TLLDTNTMKYE.YLPVEMG.DNVIVIMNTNKRR 29 Dnit55krySVQESVF.NLSHASL........MTMAIVQGKWD.LLRCCSK.DRMHQYKRMQTYP 30 I........GLNSGIM.DQFACIMgkknsa..IFLDCNTLKYE.YLPLALG.DYEIIIMATNNPH 31 P........VFVHGCN.AWAEGVG........ECLTPMILPGA.AYLLLDP.GVCVPTRELFLDP 32 Dnit55krySVQESVF.NLSHASL........MTMAIVQGKWD.LLRCCSK.DRMHQYKRMQTYP 33 I........GVNSGIM.DQFAIGFgevdka..ILLDTNTLKYE.MVPVKLD.GYAVVIMNTNKRR 34 Sga116evkDKVYGIT.ISGSGPS........IIAFPKEEFID.EVENILR.DYYENTIRTEVGK 35 V........GCNCGIM.DQLISAL........-----------.-------.------------- 36 V........GCNCGIM.DQLISAL........-----------.-------.------------- 37 Dnii55kkvELKEAVF.NVQRSAL........FVSALLTKDYK.LLREAVR.DKLHQPYREKLVP 38 I........GVNSGIM.DQFAIGMgadqca..IYLDTNTLKYD.LVPLDLK.DNVVVIMNTNKRR 39 P........FCIGGGT.AIATGRG........EILDPLPDGNC.FWVVLAK.HRSI--------- 40 Dnvm82tsyGRTDVVY.NLQRLALlt......TALGQTPINPH.LVYEVMK.DKVHQPYRASLIP 41 Sgsi60aqyRRQDIVA.HGRYLAG........FIHACHTQQPE.LAAKMIK.DVIAEPYREKLLP 42 V........GCNCGIM.DQLISAL........-----------.-------.------------- 43 Sgyh61teiPMVHHVW.NSSQAAA........LVAAVLEGDAV.MLGKALSsDKIVEPTRAPLIP 44 Sgyh61teiPMVHHVW.NSSQAAA........LVAAVLEGDAV.MLGKALSsDKIVEPTRAPLIP 45 Dnvv53ekvPFEDAVF.NIKNSCQ........FLAKIAAGKIK.EALKYVG.DRLHQNYRINGNK 46 Sgsp58ekvPLKDAIK.NLAMASS........LVLALKEGDIE.TVGRLLD.DNLALPYRKKLMP 47 Sgsi60ksyTRQNVIA.HGRHLGG........FVHACHTHQEN.LAAIMMK.DVIAEPYRESLLP 48 Dnaa62tevTHIDARF.NVSRVAV........MIVALQQ-RPD.LLWEGTR.DRLHQPYRAEVLP 49 G........TQSGGMD.QAISI--........-----------.-------.------------- 50 G........TQSGGMD.QAISI--........-----------.-------.------------- 51 Dnaa62tevTHIDARF.NVSRVAV........MIVALQQ-RPD.LLWEGTR.DRLHQPYRAEVLP 52 Dnva55hqyDRSAAIF.NASHLAL........LVQAFSQGRGD.WLALALQ.DQIHQPYRQSLIP 53 G........TQSGGMD.QAISI--........-----------.-------.------------- 54 G........TQSGGMD.QAISI--........-----------.-------.------------- 55 H........GKPSGID.TQTIVSG........KPVWFQKGQAE.TLKTLSL.DGYMVVI------ 56 V........GCNCGIM.DQMISAQgqa.....-----------.-------.------------- 57 H........GKPSGID.TKTIVTN........QPVWYQKGEVE.ILKTLDL.DGYMVVI------ 58 Sgsr57dpyLLPDIVT.QSANLAL........VLAGCYHGDAE.LVRAGLR.DVLIEPRRAPLIA 59 H........GKPSGID.TQTIVSN........KPVWFKQGQAE.TLKSLKL.NGYMVV------- 60 Q........GRASGID.PFISTFGg.......SWLFPE-----.-------.------------- 61 Dnva59keaVAASSIA.NVAVAAL........LAGDMVTAG--.--QAIEG.DLFHERYRQDLVR 62 Q........GASSGID.PTVSAVG........GFLYYKQGKFE.PLPFME-.------------- 63 S........FCVYGGT.ALATGRG........EKIKHISTPPH.CWVILAK.P------------ 64 Dnva54nelTYKEAVA.ASSIANV........LTASLLTNNLE.VAGQMMEaDRFHESYRASLIP 65 Q........DNGSCGD.IAASCYG........GWIAFSTFDHP.WLQEQET.QHSISELLALDWP 66 Q........GKASITD.TSTITYK........GILEIKNNKFR.KIK----.------------- 67 Q........GNGSCGD.IAASCYG........GWIAFSTFDHD.WVNQKVT.TETLTDLLAMDWP 68 -........-------.-------........-----------.-------.------------- 69 Agqp63envSFRDAVR.NFSRAAG........IVAAAVNGDLKsMGALMMS.DEIVEPRRRSYVP 70 P........FFLYGGT.ALVRGRG........EIVEKLED---.-------.------------- 71 S........RSIFGGF.AEWEKG-........-----------.-------.------------- 72 Q........GASSGID.PTVSAIG........GFLYYKQGEFE.HLPFV--.------------- 73 G........VNTGGMD.QCASVCG........E----------.-------.------------- 74 -........-------.-------........-----------.-------.------------- 75 P........FFLLGKS.AIGRGKG........EVLEPVETE--.-------.------------- 76 G........LNNGGMD.QCASVYGeq......GKALFIQFKP-.-------.------------- 77 S........RSIYGGF.AEWEKGY........-----------.-------.------------- 78 Q........SLSSCGD.IAVSVYS........GWLAYSTFDHD.WVKQQME.ETSVNDVLEKNWP 79 G........VNTGGMD.QCASVYGep......DKALLIQFK--.-------.------------- 80 P........FFLLGGA.ALAEGVG........ERLTPVDD---.-------.------------- 81 P........VFVRGHA.AFAEGVG........EILTPVDPPEK.WYLVAHP.GVSIPTPVIFKDP 82 C........RSIFGGF.VEWEKGHddl9yakpVPSDSFEDDLA.MVFVLIN.D------------ 83 P........FALHGGT.ALGTGRG........EELA-------.-------.------------- 84 V........GVPCGIL.DQFAVVFgregnv..IFLDTHTLDYE.YIPF---.------------- 85 P........FFFSSGS.ALGLGRG........EKV--------.-------.------------- 86 D........NAAAAVL.GGAVVSW........VDRSYDQPDYC.AVPLRLH.PDIH--------- 87 S........RSFYGPL.GAWDKDS........GEIYPVETDLK.LAMIM--.------------- 88 V........GAPVGIM.DQTAS--........-----------.-------.------------- 89 Geph57smvPLKDAVK.NIAMASS........LILALKEGDLE.TIGRLLD.DNLALPYRKKLMP 90 H........GNPSGID.AAATSSL........QPIYFTKG---.-------.------------- 91 P........FFLASQA.ACVLGGG........EQLVPLVPKTG.YLGLLVW.PGL---------- 92 P........FSLVGGA.ALGTGRG........ERLAELEVGGD.-------.------------- 93 S........RSFFGPV.AAWDKDS........GAIYKVETDLK.MAMI---.------------- 94 P........FF-----.-------........-----------.-------.------------- 95 P........FFFSTGA.ALGVARG........EKIIAL-----.-------.------------- 96 S........RSIYGGF.AEWEK--........-----------.-------.------------- 97 H........GRASGVD.AMTVGAS........RPLLFQQGRTE.RLAIGCD.S------------ 98 H........GNPSGID.AAATSGA........DPLFFTRGFP-.-------.------------- 99 S........RSIFGGF.AVWHA--........-----------.-------.------------- 100 A........FFLSGFHsANVSSCG........EIIEEFEDDIP.NLKWTFP.QISCQ-------- 101 G........VTITGAF.DDACASY........FGGLCITDNYE.MEILVKR.EINPETVV----- 102 K........LTVTGAY.DDATASY........YGGITITDNIE.RKILKRD.KMRDDLNVLILIP 103 Dnaa35pdi-------.-------........-----------.-------.------------- 104 I........GVAS---.-------........-----------.-------.------------- 105 H........GTPSGID.NAVATYG........NALLFEKDSH-.-------.------------- 106 H........GTPSGID.NAVATYG........NALLFEKDS--.-------.------------- 107 H........GRASGVD.AVTVGAT........APLLF------.-------.------------- 108 H........GKPSGVD.VTIAVRG........GVLAYRRG---.-------.------------- 109 G........VSVTGAY.DDASASF........YGGLTVTDNME.RRIILRE.PMEN--------- 110 H........GKPSGID.NTVSAYG........NMIKFCSGEIT.RLQS---.------------- 111 A........RAIYGGF.-------........-----------.-------.------------- 112 P........FFLSGYK.TAYIS--........-----------.-------.------------- 113 H........GKPSGID.NTVSAYG........NMIKFCSGEIT.RLQS---.------------- 114 Igig25dkeDFRPSSA.SKGVKPA........PIIFRHDFDWE.TILIIPK.GEHV--------- 115 C........GRPVGQQ.DHWTAAS........GAAIELRIAPD.GTADA--.------------- 116 N........FFIS---.-------........-----------.-------.------------- 117 Ig.......-------.-------........-----------.-------.------------- 118 -........-------.-------........-----------.-------.------------- 119 Igv......-------.-------........-----------.-------.------------- 120 G........ISYTGAF.DDASASM........LGGFVVSDNRK.MRLIRTD.E------------ 121 Y........I------.-------........-----------.-------.------------- 122 L........-------.-------........-----------.-------.------------- 0 | 1 GVEVV 2 EL--- 3 QL--- 4 LL--- 5 NL--- 6 LL--- 7 NL--- 8 EL--- 9 EL--- 10 EL--- 11 ELSKV 12 GL--- 13 AL--- 14 ELSKV 15 AL--- 16 GF--- 17 SL--- 18 GF--- 19 ELFEV 20 GLTEI 21 GF--- 22 GYDAV 23 EL--- 24 GLSDI 25 QL--- 26 TL--- 27 GLTEI 28 EL--- 29 VLF-- 30 T---- 31 DL--- 32 VLF-- 33 EL--- 34 G---- 35 ----- 36 ----- 37 GLS-- 38 EL--- 39 ----- 40 GLQNI 41 GF--- 42 ----- 43 GMEAV 44 GMEAV 45 KMK-- 46 WFDEV 47 NFAEV 48 ----- 49 ----- 50 ----- 51 ----- 52 AYDQ- 53 ----- 54 ----- 55 ----- 56 ----- 57 ----- 58 GF--- 59 ----- 60 ----- 61 EF--- 62 ----- 63 ----- 64 ELQ-- 65 GL--- 66 ----- 67 EL--- 68 ----- 69 CYTQV 70 ----- 71 ----- 72 ----- 73 ----- 74 ----- 75 ----- 76 ----- 77 ----- 78 GL--- 79 ----- 80 ----- 81 EL--- 82 ----- 83 ----- 84 ----- 85 ----- 86 ----- 87 ----- 88 ----- 89 WFDEI 90 ----- 91 ----- 92 ----- 93 ----- 94 ----- 95 ----- 96 ----- 97 ----- 98 ----- 99 ----- 100 ----- 101 ----- 102 NLE-- 103 ----- 104 ----- 105 ----- 106 ----- 107 ----- 108 ----- 109 ----- 110 ----- 111 ----- 112 ----- 113 ----- 114 ----- 115 ----- 116 ----- 117 ----- 118 ----- 119 ----- 120 ----- 121 ----- 122 -----