(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html

Citations (SAM, SAM-T99, HMMs)

Sequence numbers correspond to the following labels:

    • T0115 Homoserine kinase, Methanococcus jannaschii
              10             20                  30             40     
              |              |                   |              |     
   1 MREIMKVRVKAPCTSAN.....LGVGFD.....VFG.....LCLKE.....PYDVIEVEA.....
   2 -REIMKVRVKAPCTSAN.....LGVGFD.....VFG.....LCLKE.....PYDVIEVEA.....
   3 ------VKVYAPASSAN.....MSVGFD.....VLG.....AAVTPvdgalLGDVVTVEA.....
   4 -KNLPEITVYAPGRVNI.....IGEHTDyndgfVMP.....CAIN-.....FGTAVSGTK.....
   5 -KNLPEITVYAPGRVNI.....IGEHTDyndgfVMP.....CAIN-.....FGTAVSGTK.....
   6 -KNLPEITVYAPGRVNI.....IGEHTDyndgfVMP.....CAIN-.....FGTAVSGTK.....
   7 FGVEADHTFFSPGRINL.....IGEHTDynggnVLP.....VAIT-.....LGTYGAARK.....
   8 ------VKVYAPASIGN.....VSVGFD.....VLG.....AAVSPidgtlLGDCVSVEA.....
   9 FGYPATHTIQAPGRVNL.....IGEHTDyndgfVLP.....CAID-.....YQTVISCAP.....
  10 FGYPATHTIQAPGRVNL.....IGEHTDyndgfVLP.....CAID-.....YQTVISCAP.....
  11 FGYPATHTIQAPGRVNL.....IGEHTDyndgfVLP.....CAID-.....YQTVISCAP.....
  12 -------FFFAPGRVNL.....IGEHTDyngghVFP.....CALT-.....MGTYAAVAE.....
  13 ----AKDVFFSPGRINV.....IGEHTDyngghVFP.....APIS-.....LGVYGVYGP.....
  14 ------MRVKAPGRINI.....IGEHTDyndgyVLP.....FAVN-.....RFVFLTIED.....
  15 --YSAAQTVFAPGRVNI.....IGEHTDyndgfVMP.....CAIN-.....YGMAVSFSK.....
  16 FGKQAEHTFFAPGRINL.....IGEHTDyngghVFP.....CAIS-.....LGTYAAVGT.....
  17 FGPKQTAQYFSPGRINL.....IGEHTDyngghVFP.....ASIT-.....YGTQGVAAS.....
  18 -EADMLFSVTVPGSTAN.....LGPGFD.....SVG.....MALS-.....RYLKLTVFE.....
  19 ----MKKRIYAPATIAN.....FGPGFD.....VFG.....MAIEE.....PGDEVIVKE.....
  20 ------MKVKAPGRINI.....IGEHTDyndgyVLP.....FAVN-.....RYVFLSIEG.....
  21 ------IKIEVPATTTN.....FGSGFD.....TFG.....LALS-.....LTNTFSVDF.....
  22 -EADMLFSVTVPGSTAN.....LGPGFD.....SVG.....MALS-.....RYLKLTVFE.....
  23 ------VKVYAPASSAN.....MSVGFD.....VLG.....AAVTPvdgalLGDVVTVEA.....
  24 FGREADATFFSPGRINL.....IGEHTDynggrVFP.....AAIT-.....LGTYGAARK.....
  25 --------FFSPGRINL.....IGEHTDynggyVFP.....ASIT-.....IGTTGLARL.....
  26 FGASPQLFARSPGRVNL.....IGEHIDyegysVLP.....MAIR-.....QDTIIAIRK.....
  27 FGASPQLFARSPGRVNL.....IGEHIDyegysVLP.....MAIR-.....QDTIIAIRK.....
  28 --------FFSPGRINL.....IGEHTDynggyVFP.....ASIT-.....IGTTGLARL.....
  29 FGASPQLFARSPGRVNL.....IGEHIDyegysVLP.....MAIR-.....QDTIIAIRK.....
  30 EPVFVSVKTFAPATVAN.....LGPGFD.....FLG.....CAVDG.....LGDHVTLRV.....
  31 ------LRIYAPASSAN.....ISVGFD.....TLG.....AAISPidgslLGDVVQIES.....
  32 -NVGRKVTVTVPGSSAN.....LGPGFD.....TLG.....LALS-.....VYDTVEVEI.....
  33 -NVGRKVTVTVPGSSAN.....LGPGFD.....TLG.....LALS-.....VYDTVEVEI.....
  34 EPVFVSVKTFAPATVAN.....LGPGFD.....FLG.....CAVDG.....LGDHVTLRV.....
  35 ------MVVSVPATSAN.....LGPGFD.....CLG.....LSLN-.....LRNRFFIEP.....
  36 ------IKVKSPGRVNL.....IGEHTDytygyVMP.....MAIN-.....LYTKIEAEK.....
  37 ------MVVSVPATSAN.....LGPGFD.....CLG.....LSLN-.....LRNRFFIEP.....
  38 FGASPQLFARSPGRVNL.....IGEHIDyegysVLP.....MAIR-.....QDTIIAIRK.....
  39 FNTQPEVAAFAPGRINL.....IGEHTDynggyVFP.....AAIE-.....LGTYGLASK.....
  40 ------FKIKVPASSAN.....IGPGYD.....VLG.....VGLS-.....LFLELDVTI.....
  41 ------MKIIVPATSAN.....IGPGFD.....SVG.....VAVT-.....KYLQIEVSE.....
  42 ------FKIKVPASSAN.....IGPGYD.....VLG.....VGLS-.....LFLELDVTI.....
  43 ------MKILVPATSAN.....LGPGFD.....CLG.....LSLK-.....LFNETQIQK.....
  44 ----RPFTVRAPASSAN.....LGPGFD.....SLG.....LSVP-.....LYTTLRVTP.....
  45 ------MKIIVPATSAN.....LGAGFD.....SIG.....IAVN-.....LYLTVEVLG.....
  46 YGAEPEGVWAAPGRVNL.....IGEHTDyndgfVMP.....FALP-.....HQAVAAVSR.....
  47 MSVVSSVTVTVPATTAN.....LGPGFD.....CIG.....AALT-.....LYNKVKFTR.....
  48 ----VSFTVSVPATTAN.....IGPGFD.....CLG.....AALG-.....LYNHVTVTD.....
  49 ------MKVLVPATTTN.....LGAGFD.....VFG.....LALD-.....LFNEVEFSF.....
  50 ----QKFQIKVPASSAN.....IGPGFD.....VLG.....MSLE-.....EYMTLDVEV.....
  51 --------FPAPAKLNL.....DLRITGr10ieSIF.....CLID-.....LQDTVYLKP.....
  52 ----MRTQWPSPAKLNL.....FLYITGq10lqTLF.....QFLD-.....YGDTISIEL.....
  53 ------VLASAPAKVIL.....FGEHSV.....VYGkpaiaSAIE-.....LRTYVRAQF.....
  54 ------YTLHAPAKINL.....FLEILGd10lvMVL.....QSIA-.....LGDKITVRA.....
  55 -----------------.....------.....---.....MAIDK.....PFDEVVVEE.....
  56 ------THWPSPAKLNL.....FLYITGq10lqTLF.....QFLD-.....YGDTLHIEP.....
  57 PNDEIEFFARSPGRVNL.....IGDHIDynyfpVLP.....MAIE-.....VDVVAAVST.....
  58 ----SRARARAYSSAAN.....LGPGFD.....ALA.....VALDA.....YYDEVEVRV.....
  59 -PAAHQARAFAPASVAN.....VAVGFD.....LLG.....YPMDQ.....VGDTVTVRR.....
  60 PNASIDFFARSPGRVNL.....IGDHIDynffpVLP.....MAIS-.....ADVIVAVNV.....
  61 -SNGQPLRFPSPAKLNL.....FLYINGk10lqTLF.....QFLD-.....FGDWLDISI.....
  62 -SNGQPLRFPSPAKLNL.....FLYINGk10lqTLF.....QFLD-.....FGDWLDISI.....
  63 ------IRTQTPLRLGL.....AGGGTDi11gyVLN.....ATIS-.....LYIHCTLIK.....
  64 --------FSAPAKLNL.....DLRITGr10ieSIF.....CLID-.....LQDTVYLKP.....
  65 ------MIASAPGKIIL.....FGEHAV.....VYGrhavvSAIN-.....LRCRVSVRK.....
  66 ----LVASAVVAASSAN.....LGPGFD.....SIG.....LALS-.....LCDEIVVET.....
  67 ------VLASAPAKIIL.....FGEHSV.....VYGkpaiaSAID-.....LRTYVRAEF.....
  68 ------ASAVVAASSAN.....LGPGFD.....SVG.....LALS-.....LYDEIIVET.....
  69 ------VTVRVPGKVNL.....YLAVGDr10ltTVF.....HAVS-.....LVDEVTVRN.....
  70 ----MRILEKAPAKINL.....SLDVTRk10veMIM.....TTID-.....LADRIELTE.....
  71 ------MIIETPSKVIL.....FGEHAV.....VYGyraisMAID-.....LTSTIEIKE.....
  72 ------VIVRTPRRLHLgi8gsLGRKFG.....SIG.....VALE-.....GGYDIKVTP.....
  73 -------YALASGTIIN.....AIATGK.....GSA.....FGLD-.....LKVYAKVKL.....
  74 -----PFLTSAPGKVII.....FGEHSA.....VYNkp8svSALRT.....YLLISESSA.....
  75 ------MIVRTPRRLHLgm8gsLGRRFG.....SIG.....VALE-.....GGYEIKVTP.....
  76 ------MIIQTPSRIHMgl8gsIGRVDG.....GIG.....LALEE.....PNIKIEGKE.....
  77 -------NVVSPSRLHLtl8aeIGRVDG.....GVG.....ITLES.....PSLEISASE.....
  78 ----VKKTVRSPGSATV.....INAIATgr...GSA.....FGIG-.....LRVEAEAEL.....
  79 ----IELIINTPSRLHLtl8geRGRLDG.....GVG.....ITLNE.....PELVVGLEA.....
  80 ---PVIHHHFAPAKINL.....GLSVLGv10lhSLM.....VPLT-.....VGDELEIRP.....
  81 ---------FAPGHITG.....FFVICKss8tgSIG.....AGIT-.....---------.....
  82 ----MSVTVRVPAKVNV.....QLAVGAa10laNVF.....LAVS-.....LYDEVTATP.....
  83 ------------GRENL.....IGEHTDyndgfVMP.....SAL--.....PHQVAAVSR.....
  84 ----------SYAKLNL.....YLDVLGk10ivGLF.....QTIS-.....LHDTLTVEI.....
  85 ----MLIRAFVPAHITA.....FFVPIIr10slGAG.....INLS-.....KGTNVFISF.....
  86 --------WPAPAKLNL.....FLQITGr10lqTVF.....RLLD-.....WGDTIHLRV.....
  87 ----MEVKARAPGKIIL.....AGEHAV.....VHGstavaAAID-.....LYTYVTLRFplpsn
  88 ---MMRAKAYAAGTVLN.....ALPTGI.....GSA.....FGIE-.....MHTIVKLRP.....
  89 ------IKVLSPAKINL.....GLWVLGrlps.GYH.....EI---.....LTLYQEIPF.....
  90 ----VRLSLPAPAKLNL.....FLHILGr10lqTLF.....QFLD-.....HGDELHFEA.....
  91 ----MEVKARAPGKIIL.....AGEHAV.....VHGstavaAAID-.....LYTYVTLRFpl7en
  92 ----SRLTLFSPCKINV.....FLRITSk10laSLF.....HVIS-.....LGDKIKFSL.....
  93 ----SRVRVSAPSHVHAgn8gsIGRLYG.....TVG.....LALGE.....PRLTLEASP.....
  94 -----TVSYGAPGRVNL.....IGEHTDynlgfALP.....IALP-.....RRTVVTFTP.....
  95 --FKMKPRVFVPAHITG.....FFEVVMq10srGAG.....VVLD-.....RGVKTGVKL.....
  96 ------LRLRTPSRIHItl8gsIGRVDG.....GVG.....LALEE.....PHIEIKAKE.....
  97 ----MLVRAFVPAHITA.....FFVPIIr10slGAG.....VNLS-.....RGTNVFISF.....
  98 ------LRGRAPLRLGL.....GGGGTDv11grILS.....VTID-.....KYAYAFAER.....
  99 ------------AKIDL.....GYSVYKk11feSIF.....ILVEN.....IYDDIEITK.....
 100 -----IVNAFATGKGAA.....IG----.....---.....--IE-.....LWTEARVRV.....
 101 ------ARASAPGKVII.....VGEHFV.....VRGslaivAAIG-.....RRLRVTVRS.....
 102 ----MKIKCKVHASLAL.....IKYWGKk11tsSLA.....VSVDK.....FYSISELEL.....
 103 -------DVTAPLRLSL.....AGGGSDl11crLLA.....VALTA.....HGALRLAEA.....
 104 -----------------.....------e....SVM.....QR---.....------ITL.....
 105 PGDDITFFARSPGRVNL.....IGDHIDynffpVLP.....MAIA-.....NDVIAAVNV.....
 106 -----------------.....------.....---.....-----.....---------.....
 107 -----SFKIKVPASSAN.....IGPGFD.....VLG.....IGLQ-.....LYLTITVTI.....
 108 -----PFLTSAPGKVII.....FGEHSA.....VYNkp8svSALRT.....YLLISESSA.....
 109 -----------------.....------.....---.....-----.....---------.....
 110 ------MKVKAPGRINI.....IGEHTDyndgyVLP.....FAVN-.....RYVFLSIEG.....
 111 -----------------.....------.....---.....-----.....---------.....
 112 ------MQYFSPAKLNL.....FLKIWGk10ltTLY.....QAID-.....FGDTLSLKN.....


                  50             60        70                  80      
                  |              |         |                   |      
   1 IDDK.EIII...EVDDKN.....IPTDPDKNVAGIVAKKMIDDF.....NIG.....KGVKITIK
   2 IDDK.EIII...EVDDKN.....IPTDPDKNVAGIVAKKMIDDF.....NIG.....KGVKITIK
   3 AETF.SLNN...LGRFADk....LPSEPRENIVYQCWERFCQEL.....GKQ.....IPVAMTLE
   4 RDDH.IWNV...YAADLDet8lnVEIPKSEHKWANYVRGVVKFI.....QERypdfqQGANLVIS
   5 RDDH.IWNV...YAADLDet8lnVEIPKSEHKWANYVRGVVKFI.....QERyphfqQGANLVIS
   6 RDDH.IWNV...YAADLDet8lnVEIPKSEHKWANYVRGVVKFI.....QERypdfqQGANLVIS
   7 RDDK.VLRF...FSANFEe10leNLRFEKEHNWTNYPKGVLHFL.....QEAghtidSGMDIYIY
   8 AETF.SLQN...AGRFVSk....LPAEPKENIVYQCWERFCQEI.....GRE.....VPVAMRLE
   9 RDDR.KVRV...MAADYEn10daPIVAHENYQWANYVRGVVKHL.....QLRnnsf.GGVDMVIS
  10 RDDR.KVRV...MAADYEn10daPIVAHENYQWANYVRGVVKHL.....QLRnnsf.GGVDMVIS
  11 RDDR.KVRV...MAADYEn10daPIVAHENYQWANYVRGVVKHL.....QLRnnsf.GGVDMVDH
  12 RNDG.LVRM...YSDNFRn10ldDIRYQKEDDWANYPKGVIYEF.....QQRgyavpHGFDIVFS
  13 RDDK.KVRL...YSGNVDg11dtNVEKDEDRFWANYFKGMITYLrekydGID.....HGFNLYIE
  14 SGKF.VFHS...ENMNETve...MEKIEKLNRWTDYISGVIKAF.....EKRgykv.SPVKISVS
  15 RDDS.VWRV...YAIDIDeq8lsRPIEPSEHKWANYVRGVVKYI.....QEKcpefkQGADLAMT
  16 NEDN.AFRL...YSANFQrl9ifGSFQDKRGLWTDYFQGMARVM.....KTAganftHGLNVYIN
  17 RKDN.KVLV...YSTNFEd10lnELEYDKQAGWANYVKGMILKL.....KEAgytfdHGFELLVE
  18 SDKW.SFEA...ETETVA.....GIPAGTDNLIYQVAKRTADLY.....GKEm....PPVHVKVW
  19 SDSF.EIEV...EGYDVP.....R---DENNVAVISAKALFKMV.....GEE.....GGVKIRLK
  20 SERF.IFHS...ENVNETve...MEKIEKLNKWTDYISGVIASF.....EKRgyrv.SPVKISVS
  21 SDKY.EVQI...EGYSSG.....IPK-DQKNLFIKVYKKTCQSI.....GKKp....KPLKLIQE
  22 SDKW.SFEA...ETETVA.....GIR-GTDNLIYQVAKRTADLY.....GKEm....PPVHVKVW
  23 AQTF.SLNN...LGRFADk....LPSEPRENIVYQCWERFCQEL.....GKQ.....IPVAMTLE
  24 RDDK.LLRF...YSANFEe10ldHLIFNKKDSWTNYAKGVIKYL.....QEAghsidTGMDVYVF
  25 REDK.KVKL...YSENFPk10ldEVEKKDGELWSNYVKGMIVMLkgagyE--id...KGFELLIK
  26 CEDQ.KQLR...IANVNDk16idLKNHKWGHYFICAYKGFHEYAks7nlGSP.....VGLDVLVD
  27 CEDQ.KQLR...IANVNDk16idLKNHKWGHYFICAYKGFHEYAks7nlGSP.....VGLDVLVD
  28 REDN.KVKL...YSENFPk10ldDVENKDGELWSNYVKGMIVMLkgagyE--id...KGFELLIK
  29 CEDQ.KQLR...IANVNDk16idLKNHKWGHYFICAYKGFHEYAks7nlGSP.....VGLDVLVD
  30 DPSV.RAGE...VSISEItg6tkLSTNPLRNCAGIAAIATMKML.....GIRs....VGLSLDLH
  31 ISTGfELES...AGYFVRk....LPKEPQKNIVYQAYVLFSEQL.....KLRganv.KPLRLTLE
  32 IPSGlEVEV...FGEGQG.....EVPLDGSHLVVKAIRAGLKAA.....DAEv....PGLRVVCH
  33 IPSGlEVEV...FGEGQG.....EVPLDGSHLVVKAIRAGLKAA.....DAEv....PGLRVVCH
  34 DPSV.RAGE...VSISEItg6tkLSTNPLRNCAGIAAIATMKML.....GIRs....VGLSLDLH
  35 SSFH.AVKL...VGEGEG.....IPKFLTNNIFTKVFYEILKKH.....GND.....GSFKFLLH
  36 HGEV.ILYS...EHFGEErkfs.LNDLRKENSWIDYVKGIFWVL.....KESdyev.GGIKGRVS
  37 SNIH.AVKL...VGEGEG.....IPKFLTNNIFTKVFYEILKKH.....GND.....GSFKFLLH
  38 CEDQ.KQLR...IANVNDk16idLKNHKWGHYFICAYKGFHEYAks7nlGSP.....VGLDVLVD
  39 RNDN.KICL...YSNNFEs10ldELQFDTTHSWANYPKGMVKFLkesgyQ--id...SGFNILIE
  40 DSSQ.AQET...NDDPNNc14stVPLRSDANLITRTALYVLRCN.....NIRnfp..SGTKVHVS
  41 ERDE.WLIE...HQIGKW.....IPHDERNLLLTIALQIVPDLQ.....PRR.....----LKMT
  42 DSSQ.AQET...NDDPNNc14stVPLRSDANLITRTALYVLRCNir...NFP.....SGTKVHVS
  43 SGVF.SISI...GGEGSD.....NIFLKKNNIFVNIFYEIYEKLs....GKK.....DNFRFIFQ
  44 QDKA.EVVP...LGTELA.....DTPADESNYVYRAMTLAAKRA.....GRTl....PPARVEIE
  45 ESRD.WKID...HDLGEN.....IPT-DERNLLLTTLSAVLEDK.....NVAls...AKFHLKMT
  46 RDDG.ILRL...HSADIDad9vaDLAPGSDKSWTAYPSGVLWAL.....REAghel.TGADVHLA
  47 LDAG.GLII...HVTGKEae...GVNTDESNLLYQAFVKLYQHIe....QIP.....PSVKIEID
  48 PTDP.EVDL...LIEARGrdge.KISTTKDNLLYQAIAYFYQQT.....GQAi....PPLKLEID
  49 -DTK.ETTI...ESTGKY.....ASDLKDHNLFFEVLRFFERKT.....GYRv....PPVRIKQT
  50 STES.GPCV...LTYEGDgkeh.VSLDVQKNMITQTSLYVLRCN.....NIStfp..YATKIHVI
  51 RDDG.KIIL...HNPVDG.....MP--QEADLSYRAASLLQKYA.....RTP.....TGVEIWLD
  52 RDDG.DIRL...LTPVEG.....VE--HEDNLIVRAARLLMKTAad6rlPTG.....SGANISID
  53 NDSG.NIKI...EAHDIKt12dkIYFETDYGKAAEVLSYVRYAIel7esDKR.....VGIDVSIT
  54 NGTD.DIRL...SCGDSP.....LAN-DATNLAYRAAQLMINNF.....PQAhdny.GGVDITLT
  55 FNEF.EIIS...SGYPVP.....N---GEDNIALFSAKTLFKML.....NIE.....GGLRIKLK
  56 RHDG.EIHL...LTPVNG.....VE--NEDNLIVRAARLLMKVA.....SESgr6agSGADISIE
  57 NNND.MIVI...ANTDSAk12eeFTIDREHHTWANYFKCGLIVA.....SKFlq9klKGMNITFS
  58 CSGG.NSVY...VDEVEGkfs..SGVLQGPNTAAEAVRGLLNME.....GVE.....AEVGIRVY
  59 IDTP.QVRIaaiRGIAQP.....LPLQTERNTAGAALLSMHRDL.....ALP.....FGFELEID
  60 NDEP.EIVI...THTDSKn15dgFEIDSQHHSWANYFKCALIVA.....NNYl10qlKGMKLTFD
  61 REQD.NQIV...LTPEIP.....NLK-TENNLIYRAAKLLQEKA.....NIQ.....LGANIHLD
  62 REQD.NQIV...LTPEIP.....NLK-TENNLIYRAAKLLQEKA.....NIQ.....LGANIHLD
  63 REDG.KIIF...DSPDTNs10efLGNDGKLDIFKSIYNRIVKDF.....TKKp....LSFSLHTY
  64 RDDG.KIIL...HNPVDG.....MP--QEVDLSYRAASLLQKYA.....RNP.....AGVEIWLD
  65 SDRF.LIRS...SLGESG.....LDY-QRHPYVVQAVKRFGELR.....NIP.....-GAEIEIE
  66 TDSGlVVVV...DGEGAD.....QVPMGPEHLVVRAVRRGLQAV.....GVSa....AGLVVRCR
  67 NDSG.NIKI...EAHDIKt22ka---AEVLSYVRHAIELVLEEA.....DKR.....TGVSVSIT
  68 TDSGlTVTV...DGEGGD.....QVPLGPEHLVVRAVQHGLQAA.....GVSa....AGLAVRCR
  69 ADVL.SLEL...VGEGAD.....QLPTDERNLAWQAAELMAEHV.....GRA.....PDVSIMID
  70 LAED.EVRV...SSHNRF.....VPD-DQRNLAYQAAKLIKDRY.....NVK.....KGVSIMIT
  71 TQED.EIIL...NLNDLNk14inPNNFGDFKYCLCAIKNTLDYL.....NIEpk...TGFKINIS
  72 AGSL.TIEA...DK----.....----EDREVIEKIVKELNLEY.....ETG.....LDYYIEVR
  73 IDDG.KNKI...EGKVLD.....NPN-IKPNLIVRCVKNTLDYF.....GLN.....YSAYVETK
  74 PDTI.ELDF...PDISFNh45aqLSESFHYHAAFCFLYMFVCLC.....PHA.....KNIKFSLK
  75 AGSL.TIEA...DE----.....----EDRKVIERVVKELNLKY.....ETG.....LDYYIEVR
  76 SDDI.SIEF...DKKLIEkyge.DYIKSVRDRVYNTAIKVLDVI.....GGE.....-GVDLKIL
  77 ADTV.EVV-...------.....----GSSLLAGRMLKAAKAVI.....PEG.....KGIKIHIK
  78 IDSG.VECI...SREG--.....----ADTSLMELCTRMVIEHY.....GVD.....AGVRVVTS
  79 SDDM.GVEF...TSHAEG.....KLREEYRSKIMEAARRTLKHI.....GSD.....EKFHFTVR
  80 AGAL.TLRV...EGADLP.....T---DERNLVYRAARAYLDAA.....GAA.....GGADLVLH
  81 IDRG.VNVE...LKEGNG.....SIFYNNKKVNICAVEKVIEHYkkf..GYN.....DDYDIIFS
  82 AADGlRVTC...EGPDAG.....QVPLDRTNLAARAAEALAARY.....GRA.....PDVHLHIA
  83 RERR.ILRL...HSADVDad9vaDLAPASDKSWTAYPSGVLWAL.....REAghel.TGADVHLA
  84 CDRG.FYLE...SSVA--.....---LPSDNTIKRAWEMFRKNT.....GKE.....FGLKVTLK
  85 EESL.EKHV...HVAFNG.....EPVKKEDARITYHVIEKILPE.....DYI.....GEVEVWQY
  86 REDG.QIHR...IGESVT.....GVV-EADDLVVRAAYLLKYAT.....NVH.....LGADIFVE
  87 NDRL.TLQL...KDISLEf40veEQNLPKEKMWLSSGISTFLWL.....YTRiigf.NPATVVIN
  88 SDEL.KVFV...NGVERR.....SIV----------AERILNSM.....DV-.....-TAEVIVE
  89 YDEI.YIRE...GVLRVEtn...IGIPQEENLVYKGLREFERIT.....GIE.....INYSIFIQ
  90 RQDG.QVRL...HTEIAG.....VP--HDSNLIVRAARGLQEAS.....GSP.....QGVDIWLD
  91 NDRL.TLQL...KDISLEf40veEQNLPKEKMWLSSGISTFLWL.....YTRiigf.NPATVVIN
  92 SPSK.SKDR...LSTNVA.....GVPLDERNLIIKALNLYRKKT.....GTD.....NYFWIHLD
  93 SHSV.EVEG...G-----.....----SRRREAEDLARLYLDKV.....GSRgcrl.EGVKIRIY
  94 EHTG.AITA...RSDRADgs7plDTTPGQVTGWAAYAAGAIWAL.....RGAghpv.PGGAMSIT
  95 RGSD.DTTK...VRVNGR.....R---DDDGVSIRAVEILRELT.....GFS.....EGVSIHHE
  96 SETF.VLKG...EPI---.....-----NRERFEIAAAKMAEYC.....GR-.....-GAEIEVV
  97 EESL.ERHV...HVALNG.....EPVKREDAKVTFHVIDKMLPQ.....EYV.....GEVEVWQY
  98 GTGD.EIAF...RSPDRDr10dlASLEEDFPLHVAVYRRVIAEF.....NGGtp...FPLQLATQ
  99 IEKN.IDDV...HYYNET.....NEIYVYSRLVHKTLEWIRHTY.....HIK.....NHYRINIK
 100 TGDG.EVRG...KIVVKG.....EEF-KDYRLVNSVISVLREVT.....GEP.....FGVRFEIH
 101 GGKG.IVLE...SSMLGRh12aa--KVSPVLEPYIAVLRSLAAR.....GYSv....VPHTILVE
 102 SNRD.EIIL...NS--KP.....VILKNREKVFFDYARKILNEP.....NV-.....-RFKIKSK
 103 PEGV.TVRA...FGTETR.....AE--HASSHPDPLVRAALGYF.....GID.....RGVHLTVE
 104 ADSL.SLSR...LDIPGRce6spYMALPRENTLTRAYARFCQVT.....GVH.....DGVRVRVV
 105 NSTN.EIII...TNTDSKd11rnSQIDQEHHSWANYFKCALIVA.....KQYle9slKGMKLTFN
 106 ----.----...------.....----HEDNLIVRAARLLMKTAad6rlPTG.....SGANISID
 107 DPSI.DTSS...DPHHALls8gkVPFESNENLITQTALYVMRCN.....GIKdfp..RGTHIHVN
 108 PDTI.ELDF...PDISFNh45aqLSESFHYHAAFCFLYMFVCLC.....PHA.....KNIKFSLK
 109 ----.----...------.....----LEENSLFKALQILKNFL.....KSKn10slDTLAIEVE
 110 SERF.IFHS...ENVNETve...MEKIEKLNKWTDYISGVIASF.....EKRgyrv.SPVKISVS
 111 ----.----...------.....-----EENSLFKALQVLKKFLvqk..NFShs7slDTLAIEVE
 112 SMKD.SLSS...NV----.....NELLSPSNLIWKSLEIFRRET.....QIH.....QPVSWHLN


        90       100            110            120       130       140 
        |         |              |              |         |         | 
   1 KGVKAGSGLGSSAASSAGTAYAI.....NELFKL.....NLDKLKLVDYASYGELASSGAKHAD.
   2 KGVKAGSGLGSSAASSAGTAYAI.....NELFKL.....NLDKLKLVDYASYGELASSGAKHAD.
   3 KNMPIGSGLGSSACSVVAALMAM.....NEHCGK.....PLNDTRLLALMGELEGRISGSIHYD.
   4 GNVPLSSGLSSSAALEVAVGKFC.....QQLGDL.....PLSHTDIALNGQKAENQFVGANCGNm
   5 GNVPLSSGLSSSAALEVAVGKFC.....QQLGNL.....PLSHTDIALNGQKAENQFVGANCGNm
   6 GNVPLSSGLSSSAALEVAVGKFC.....QQLGDL.....PLSHTDIALNGQKAENQFVGANCGNm
   7 GNIPNGSGLSSSSSLELLIGVIV.....EKLYDI.....KLERLDLVKIGKQTENDFIGVNSGIm
   8 KNMPIGSGLGSSACSVVAGLMAM.....NEFCDR.....PLDKTTLLGLMGELEGRISGSVHYD.
   9 GNVPQGAGLSSSASLEVAVGTVL.....QQLYHL.....PLDGAQIALNGQEAENQFVGCNCGIm
  10 GNVPQGAGLSSSASLEVAVGTVL.....QQLYHL.....PLDGAQIALNGQEAENQFVGCNCGIm
  11 GNVPQGAGLSSSASLEVAVGTVL.....QQLYHL.....PLDGAQIALNGQEAENQFVGCNCGIm
  12 GNIPNGAGLSSSASIELLMGVVL.....QSYFHP.....EVDALELVKMAQHAENHFIGVNCGIm
  13 ANLPSGSGLSSSAAIEMLMGIIL.....KDEFNL.....DVDRVSLAKMGQRTENEFIGLNSGIm
  14 SNLPMGAGLSSSAALEMATAYAI.....SEHFGF.....HLPKLELVKIAREAEVEFVGVRCGIm
  15 SDVPMSSGLSSSAALEISIGKTA.....RVLGDL.....PLSLTEIALIGQQAENKFVGANCGNm
  16 GNLPDGAGLSSSASLEMLVGTIL.....NSLFDG.....GFEPLELVQFGVKVENDYIGVNSGVm
  17 GTIPNGAGLSSSASLELLVGVVL.....EDLFDL.....AIDRLALVQTGKKVENEFIGVNSGIm
  18 SDIPLARGLGSSAAAIVAAIELA.....DELCGL.....KLSEADKLHLASLEE------GHPD.
  19 KGVRPKSGLGSSGASSVAGALAA.....ARVLGV.....DNDELIIM-AALEGEKAASGSPHGD.
  20 SNLPIGAGLSSSAALEVATAYAI.....SEYFGF.....NVPKLELVKIAREAEVEFVGVRCGIm
  21 NRVPPARGLGSSATAIVGGIEAA.....LALHKV.....ELPLKEKLKIAFEFE------KHPD.
  22 SDIPLARGLGSSAAAIVAAIELA.....DELCGL.....KLSEADKLHLASLEE------GHPD.
  23 KNMPIGSGLGSSACSVVAALMAM.....NEHCGK.....PLNDTRLLALMGELEGRISGSIHYD.
  24 GNIPNGSGLSSSSSLELLIGIMA.....EELFDL.....KLDRLDLVKIGKRTENDFIGVNSGIm
  25 GEIPTASGLSSSASLELLVGVVL.....DDLFNL.....NVPRLELVQLGQKTENDYIGVNSGIl
  26 GIVPTGSGLSSSAAFVCSATIAI.....MAVFGH.....NFEKKELAQLTCECERHIGTQSGGM.
  27 GIVPTGSGLSSSAAFVCSATIAI.....MAVFGH.....NFEKKELAQLTCECERHIGTQSGGM.
  28 GEIPTASGLSSSASLELLVGVVL.....DDLFKL.....SVPRLELVQLGQKTENDYIGVNSGIl
  29 GIVPTGSGLSSSAAFVCSATIAI.....MAVFGH.....NFEKKELAQLTCECERHIGTQSGGM.
  30 KGLPLGSGLGSSAASAAAAAVAV.....NEIFGR.....KLGSDQLVLAGLESEAKVSG-YHAD.
  31 KNMPIGSGLGSSACSIVAALVAL.....NQFHNE.....PFSKMELLEMMGELEGRISGSIHYD.
  32 NNIPQSRGLGSSAAAAVAGVAAA.....NGLADF.....PLTQEQIVQLSSAFE------GHPD.
  33 NNIPQSRGLGSSAAAAVAGVAAA.....NGLADF.....PLTQEQIVQLSSAFE------GHPD.
  34 KGLPLGSGLGSSAASAAAAAVAV.....NEIFGR.....KLGSDQLVLAGLESEAKVSG-YHAD.
  35 NKVPITRGMGSSSAMIVGAVASA.....FAFLGF.....DFDRENIVNTALIYE------NHPD.
  36 GNLPLGAGLSSSASFEVGILETL.....DKLYNL.....KLDSLSKVLLAKKAENEFVGVPCGIl
  37 NKVPITRGMGSSSAMIVGAVASA.....FAFLGF.....AFDRENILNTALIYE------NHPD.
  38 GIVPTGSGLSSSAAFVCSATIAI.....MAVFGH.....NFEKKELAQLTCECERHIGTQSGGM.
  39 GNIPNGASLSSSASIEILMGWLL.....KALFNL.....EVERLELIELGRKVENQFIGVNSGIm
  40 NPIPLGRGLGSSGAAVVAGVILG.....NEVAQL.....GFSKQRMLDYCLMIE------RHPD.
  41 SDVPLARGLGSSSSVIVAGIELA.....NQLGQL.....NLSDHEKLQLATKIE------GHPD.
  42 NPIPLGRGLGSSGAAVVAGVILG.....NEVAQL.....GFSKQRMLDYCLMIE------RHPD.
  43 NNIPLSRGLGSSSAVIVGAIASA.....YYMSGF.....KVEKECILDEALIYE------NHPD.
  44 TEVPLARGLGSSAAALVAGVVAG.....NELLGR.....PLDDETVLDVTAREE------GHPD.
  45 SEVPLARGLGSSSSVIIAGIELA.....NQLAKL.....NLTSDEKLKLACEIE------GHPD.
  46 STVPSGAGLSSSAALEVVLALAM.....NDLYAL.....GLRGWQLARLCQRAENVYVGAPVGIm
  47 LGVPLARGLGSSATAIVGGLVAA.....NQLAGE.....PLSQLQVMELAIAME------GHPD.
  48 LEIPLARGLGSSATAIVGGLLAA.....NQAAGN.....PCTTSEILQMAIAME------GHPD.
  49 CNIPVSSGLGSSAAVIVAALHIA.....NEGTGR.....NLSREDLMKLAVELE------GHPD.
  50 NPIPLGRGMGSSGSAAIAGVMLA.....NEIAKL.....GLSKLQMMDYVLMIE------RHPD.
  51 KKIPTGAGLGGGSSDAATVLLVL.....NRWWQC.....GLTQRQLIDSGA---------ALGA.
  52 KRLPMGGGLGGGSSNAATVLVAL.....NHLWQC.....GLSMDELAEMGL---------TLGA.
  53 SQIPVGAGLGSSAAVAVATIGAV.....SRLLGL.....ELSKEEIAKLGHKVELLVQGASSGI.
  54 KHIPMAAGLAGGSADAAAVLVGL.....DLLWNL.....GLTRPELEQLAA---------QLGS.
  55 KGIRPKSGLGSSGASAVAGALGA.....AKLLGV.....SN-DELILKAAMKGEEKASGEPHPD.
  56 KRLPMGGGLGGGSSNAATVLVAL.....NHLWQC.....GLSIDELATLGL---------TLGA.
  57 GTVPTGGGLSSSAAFCVASTLAV.....LYANGVe....DISKADLTRITVVSEHYLGLNNGGM.
  58 KGVPPGRGLGSSGASAAAAVAAV.....SHALAL.....EVPVDRLVFYAGLGERAAAGQPHFD.
  59 KGIPLSSGMGGSAASCVAALLAA.....NALLEE.....PLRREHLYRYALDGEAVASGSRHGD.
  60 GNVPTGGGLSSSAAFCVASTLAI.....LHANGVk....DITKADLTRITVVCEHYVGVNTGGM.
  61 KILPMGGGVGGGSSNAATALVSL.....NYLWQA.....NLSIDELAKLGL---------TLGA.
  62 KILPMGGGVGGGSSNAATALVSL.....NYLWQA.....NLSIDELAKLGL---------TLGA.
  63 SDVPSGSGLGGSSTLVVGVIKAF.....AEWLNL.....PLGEYEIAKLAYEIEREDLGIVGGAq
  64 KKIPTGAGLGGGSSDAATVLLVL.....NRWWQC.....GLTQRQLIDSGA---------ALGA.
  65 SEIPIGSGLGSSAAVIVATIAAL.....NAEFDG.....DMDKEAIFQMAKQVEIDVQGRASGI.
  66 NAIPHSRGLGSSAAAVVGGLAVV.....NGFVAQidst.PLSNAQLIQLASEFE------GHPD.
  67 SQIPVGAGLGSSAAVAVATIGAV.....SKLLDL.....ELSKEEIAKMGHKVELLVQGASSGI.
  68 NAIPHSRGLGSSAAAVVGGLAAV.....NGLVVQtdss.PSSDAELIQLASEFE------GHPD.
  69 KSIPVAGGMAGGSADAAAVLVAM.....NSLWEL.....NVPRRDLRMLAA---------RLGS.
  70 KVIPVAAGLAGGSSDAAATLRGL.....NRLWNL.....NLSAETLAELGA---------EIGS.
  71 SKIPISCGLGSSASITIGTIKAV.....SGFYNK.....ELKDDEIAKLGYMVEKEIQGKASIT.
  72 KSIPRHIGLGSTTQLTLAIASAI.....LRIAKK.....DIPIEEVAFSLKRAR------ESGA.
  73 TEIPIKSGLSSSSATSNAVVLAT.....FDALGE.....KIDDELILNLGIKSSFDEKLTVTGAy
  74 STLPIGAGLGSSASISVSLALAM.....AYLGGLi10lsENDKHIVNQWAFIGEKCIHGTPSGI.
  75 RSIPRHIGLGSTTQLTLAIASAI.....LRIAKK.....EVPIEDVAFSLGRSR------ESGA.
  76 SLFPAHSGLGSGTQLSLAVGKLI.....SKIYNK.....EMNAYNIAKITGRGG------TSGI.
  77 RDLPDHVGLGSGTQAALSVAAAI.....NEIYGL.....GKSVRELAVAVGRGG------TSGI.
  78 SDLPVASGLSSSSAASNATVMAV.....SSLLSDefglqPMEDFEMLNMAVDASLQAGVSVTGAy
  79 SMFPAHSGLGSGTQLSLATARLV.....AEYHGM.....KFTARELAHIVGRGG------TSGI.
  80 KRLPLASGLGGGSSDAASTLLAL.....AELYPAp....DHRPVDLPALAL---------TLGA.
  81 SDFPLGSGLGMSGGCALILAKKL.....NEMLNL.....NENYAEIAHISEVEC------GTGLg
  82 KDIPVAGGMAGGSADGAGALLAC.....DALWGT.....GASREELLEICA---------GLGS.
  83 STVPSGAGLSSSAALEV-RPLAM.....NDLYAL.....ALRGWQLARLCQRAENVYVGAPVGIm
  84 KEIPVGSGLGGGSSNAAAVLRYL.....GEVFKI.....PL--EDLLNIAA---------QVGS.
  85 FDYPTGHGYGNSAGGALGTALGL.....SYKFGG.....TL--LSASRIAHEAEVIH---KGGLg
  86 KRIPVGGGFGGGSSDAATVLLVL.....NALWHT.....RLDVAVLAALGL---------RLGA.
  87 SELPYGSGLGSSAALCVALTAALl11rgNGWSSLd....ETNLELLNKWAFEGEKIIHGKPSGI.
  88 SEIPGGSGLGSSSAFVNALICAV.....KKMKGE.....ELNAFEILRSNARFSLEAGISYTGAf
  89 KNIPPGAGLGGGSSNLAVVLKKV.....NELLGS.....PLSEEELRELVG---------SISA.
  90 KRLPMGGGIGGGSSDAATTLLAL.....NHLWQL.....GWDEDRIAALGL---------RLGA.
  91 SELPYGSGLGSSAALCVALTAALl11rgNGWSSLd....ETNLELLNKWAFEGEKIIHGKPSGI.
  92 KKVPTGAGLGGGSSNAATTLWAA.....NQFSGC.....VATEKELQEWSG---------EIGS.
  93 EEIPAHVGLGSTTALALSIGSSI.....YRICGLe....PLDLRELAVTAGRSLVSALGLYSFE.
  94 SDVEIGSGLSSSAALIGAVLGAV.....GAATGT.....RIDRLERARLAQRAENDYVGAPTGLl
  95 VEVPIGCGFGTSAACALGSVLAI.....ASELEL.....PITFNMAGEVAHRAEVEL---GTGLg
  96 SDYDAHVGLGSGTQISLAVGRAF.....SELYGL.....NLTTRQIAEIMGRGG------TSGI.
  97 FDYPTGHGFGNSGGGALGTALCL.....AYKFRR.....TL--LSAAKVAHEAE---VLNRGGLg
  98 VDAPPGSGLGSSSALVVAMLLTT.....CALIGS.....SPGPYELARLAWEIERVDLGMAGGWq
  99 KRIPIGAGLGGGSSNAAAIMKYI.....LEFEGIk....EINYKDVVN------------KLGA.
 100 SDIPVGKGLKSSSAAANSLTKAL.....VEALRL.....NIDDLSIVKLGVEAAKRAGVTITGAf
 101 SGIPPRAGLGSSAASMVAYALSY.....SAMHGD.....PLSAEDLYSVAMEGEKIAHGKPSGV.
 102 NNFPTAAGLASSSSGFASIAACI.....LKYFNKys...CNSASNLARVGS------------A.
 103 SDVAPGSGLGGSGAFLVALATAL.....SHLTGD.....PLTPAAAARAAFRIERALCGRPVGQq
 104 KRIPAGSGLGGGSADAAALLCGL.....DTLFGT.....TLSARVLREVAY---------SVGS.
 105 GNVPTGGGLSSSAAFCVASTLAI.....IRANGIt....DLTKQDLTRITVVSEHYVGVNTGGM.
 106 KRLPMGGGLGGGSSNAATVLVAL.....NHLWQC.....GLSMDELAEMGL---------TLGA.
 107 NPIPLGRGLGSSASAIVAGVYLG.....NEIGNL.....KLDKYRLLDYCLMIE------RHPD.
 108 STLPIGAGLGSSASISVSLALAM.....AYLGGLi10lsENDKHIVNQWAFIGEKCIHGTPSGI.
 109 KNIPTQAGLGGGSTDAGGLLYHL.....NQIFDW.....RLSLEELYSMGS---------LVGA.
 110 SNLPIGAGLSSSAALEVATAYAI.....SEYFGF.....NVPKLELV-----------------.
 111 KNIPTQAGLGGGSADAGGLLYHL.....NQMFDW.....RLSLKELYTMGS---------LVGA.
 112 KSIPLQSGLGGGSSNAATALYAL.....NEHFQT.....HIPITTLQLWAR---------EIGS.


                   150                 160                   170       
                    |                   |                     |       
   1 .NVAPAIFG.....GFT..MVT.....NYE...PLE.....V..LHIPI.....DFKLDILIAIP
   2 .NVAPAIFG.....GFT..MVT.....NYE...PLE.....V..LHIPI.....DFKLDILIAIP
   3 .NVAPCFLG.....GMQ..LMI.....EEN...DII.....S..QQVPG.....FDEWLWVLAYP
   4 .DQLISALGqe...NHL..LMI.....DCR...SLE.....T..TPTPV.....PQDVAVIIVNS
   5 .DQLISALGqe...NHL..LMI.....DCR...SLE.....T..TPTPV.....PQDVAVIIVNS
   6 .DQLISALGqe...NHL..LMI.....DCR...SLE.....T..TPTPV.....PQDVAVIIVNS
   7 .DQFAIGMGad...QCA..IYL.....DTN...TLK.....Y..DLVPLd....LKDNVVVIMNT
   8 .NVAPCYLG.....GLQ..LML.....EEE...GII.....S..QEVPC.....FDDWLWVMAYP
   9 .DQLISALGkk...DHA..LLI.....DCR...SLG.....T..KAVSM.....PKGVAVVIINS
  10 .DQLISALGkk...DHA..LLI.....DCR...SLG.....T..KAVSM.....PKGVAVVIINS
  11 .DQLISALGkk...DHA..LLI.....DCR...SLG.....T..KAVSM.....PKGVAVVIINS
  12 .DQFAIGMGkk...HHA..MLL.....NCD...TLD.....Y..EYSKLn....VSGLALVIANT
  13 .DQFACIMGkk...NSA..IFL.....DCN...TLK.....Y..EYLPLa....LGDYEIIIMAT
  14 .DQFTSAFGkk...DHA..IFL.....DTM...TLE.....Y..EYVPLk....LEGYEINLVDS
  15 .DQLTSALGqk...DQV..IMI.....DCR...SLD.....I..TPTPV.....PHGYSIAIINS
  16 .DQFAIEMGra...NQA..TLL.....DTN...TMK.....Y..EYLPVe....MGDNVIVIMNT
  17 .DQFAIGFGev...DKA..ILL.....DTN...TLK.....Y..EMVPVk....LDGYAVVIMNT
  18 .NAGASLVG.....GLV..IGL.....HED...DET.....Q..MIRVP.....NADIDVVVVIP
  19 .NVIPSYYG.....GFN..ILE.....SLN...PLR.....V..HRVD-.....-VELNVVVVLP
  20 .DQFTAVFGkk...DHA..IFL.....DTM...TLE.....Y..EYVPLk....LEGYEINLVDS
  21 .NIIPAFVG.....GFTv.CAT.....SES...GVI.....F..KKLPF.....PEDIKIVFVIP
  22 .NAGASLVG.....GLV..IGL.....HED...DET.....Q..MIRVP.....NADIDVVVVIP
  23 .NVAPCFLG.....GMQ..LMI.....EEN...DII.....S..QQVQG.....LMSGCGCSRIR
  24 .DQFAIGMGae...KKA..IYL.....DTK...TLE.....Y..DLVPLd....LGDNVIVIMNT
  25 .DQFAIGFGev...KKA..ILL.....DCN...TLK.....Y..EMVPVe....LRDYDIVIMNT
  26 .DQAISIMAkt...GFA..ELI.....DFN...PVR.....A..TDVKL.....PDGGSFVIAHS
  27 .DQAISIMAkt...GFA..ELI.....DFN...PVR.....A..TDVKL.....PDGGSFVIAHS
  28 .DQFAIGFGev...KKA..ILL.....DCN...TLK.....Y..EMVPVe....LRDYDIVIMNT
  29 .DQAISIMAkt...GFA..ELI.....DFN...PVR.....A..TDVKL.....PDGGSFVIAHS
  30 .NIAPAIMG.....GFV..LIR.....NYE...PLD.....L..KPLRFps...DKDLFFVLVSP
  31 .NVAPCYLG.....GVQ..FMV.....QSL...GNI.....C..QKLPF.....FDNWYWVLAYP
  32 .NAAASVLG.....GAV..VSWtn6idGKS...QPQ.....Y..AAVPLev...QDNIRATALVP
  33 .NAAASVLG.....GAV..VSWtn6idGKS...QPQ.....Y..AAVPLev...QDNIRATALVP
  34 .NIAPAIMG.....GFV..LIR.....NYE...PLD.....L..KPLKFps...DKDLFFVLVSP
  35 .NITPAVFGg....YNA..AFV.....EKK...KVI.....S..LKTKI.....PSFLKAVMVIP
  36 .DQFAVVFGre...GNV..IFL.....DTH...TLD.....Y..EYIPF.....PKDVSILVFYT
  37 .NITPAVFGg....YNA..AFV.....EKK...KVI.....S..LKTKI.....PSFLKAVMVIP
  38 .DQAISIMAkt...GFA..ELI.....DFN...PVR.....A..TDVKL.....PDGGSFVIAHS
  39 .DQFIVGMGrk...DQA..ILL.....DTA...TLE.....Y..HYVPTe....FGDYVISIMNT
  40 .NITAAMMG.....GFCgsFLR.....DLT...PQEv34grH..VKYQW.....NPAIKCIAIIP
  41 .NVAPAIYG.....NLV..IAS.....SVE...GQV.....S..AIVAD.....FPECDFLAYIP
  42 .NITAAMMG.....GFCgsFLR.....DLT...PQEv34grH..VKYQW.....NPAIKCIAIIP
  43 .NIAPATLG.....GFV..CSLv....EKN...KVY.....S..IKKEI.....DKDLAAVVVIP
  44 .NVAPALFG.....GIV..VATl....DKL...GTH.....Y..VRLDP.....PAHLGVTVLVP
  45 .NVAPALLG.....NLV..IAS.....TVA...GKT.....S..HIVAD.....FPSCALLAFVP
  46 .DQTASACCea...GHA..LFL.....DTR...DLS.....Q..RQIPFdla..AEGMRLLVVDT
  47 .NVVPALLG.....GCR..LAAt....SAE...GWE.....I..CDVPW.....DENVVPVVAIP
  48 .NVAPALLG.....GCQ..LAV.....KNG...DHWq....L..VALDW.....PSKFVPVLAIP
  49 .NVVPAFTG.....GLV..VCY.....QNG...SHL.....-..DFEKF.....EIDLSLTFLVP
  50 .NVMASMMG.....GFVgsFLR.....ELS...EEEk26gtF..ARLPW.....ASELKAIVVIP
  51 .DVPFFIFG.....KNA..FAR.....GIG...DRL.....D..EMD--.....IPKQWYVIVKP
  52 .DVPVFVRG.....HAA..FAE.....GVG...EIL.....T..PVDP-.....-PEKWYLVAHP
  53 .DPTVSAVG.....GFL..Y--.....-YK...QGK.....F..EPLP-.....FMELPIVVGYT
  54 .DIPFCIGG.....GTA..IAT.....GRG...EIL.....D..PLPDG.....NCFWVVLAKHR
  55 .NVVPSYYG.....GFT..VIE.....SKS...PLR.....V..HFVD-.....-AKLRGVVVLP
  56 .DVPVFVRG.....HAA..FAE.....GVG...EIL.....T..PVNP-.....-PEKWYLVAHP
  57 .DQCASVYGeq...GKA..LFI.....QFK...PQLk....G..TPFEF.....PVKNLTFVITN
  58 .NAAASILG.....GLA..VVA.....SDA...AGK.....L..RVFRV.....PFKAWFAVVTP
  59 .NLGPLFLG.....GLV..LCTl....---...-ER.....L..VPVTV.....PAAWHSLLVHP
  60 .DQCASVYGep...DKA..LLI.....QFK...PKL.....Ig.KPFKF.....PVENLTFVITN
  61 .DVPIFVHG.....HAA..FAE.....GVG...EKI.....T..YCEP-.....-AEKWFVILKP
  62 .DVPIFVHG.....HAA..FAE.....GVG...EKI.....T..YCEP-.....-AEKWFVILKP
  63 .DQYAATFG.....GFN..FME.....FYN...NKR.....V..IVNPLri8asELEARTVLYFT
  64 .DVPFFIFG.....KNA..FAR.....GIG...DRL.....D..EMD--.....IPKQWYVIVKP
  65 .DPFISTFG.....GSW..LFP.....ERR...KVE.....M..PFKF-.....-------FVIN
  66 .NAAAAVLG.....GAV..VSWvdr..SYD...QPD.....Y..CAVPLrl...HPDIHLFAAIP
  67 .DPTVSAIG.....GFL..Y--.....-YK...QGE.....F..EHLP-.....FVELPIVVGYT
  68 .NAAAAVLG.....GAV..VSWtdhsgDRP...NYS.....A..VSLRL.....HPDIRLFTAIP
  69 .DVPFALHG.....GTA..LGT.....GRG...EEL.....A..TVLS-.....RNTFHWVLAFA
  70 .DVSFCVYG.....GTA..LAT.....GRG...EKI.....-..KHIST.....PPHCWVILAKP
  71 .DTSTITYK.....GIL..EIK.....NNK...FRK.....IkgEFEEF.....LKNCKFLIVYA
  72 .GLYIFKFG.....GFV..VDG.....GVKdtyPPL.....I..MRHDF.....PENWAFILVIP
  73 dDATASYYG.....GIT..ITD.....NIE...RKI.....L..KRDKM.....RDDLNVLILIP
  74 .DNAVATYG.....NAL..LFE.....KDS...HNGti6nnF..KFLDD.....FPAIPMILTYT
  75 .SLYVFKYG.....GLV..IDG.....GVKdkyPPL.....V..MRHEF.....PENWAFLLVIP
  76 .GIGAFEYG.....GFL..IDG.....GHS...FGKg20ap-..IIFRH.....DFDWETILIIP
  77 .GVAAFEYG.....GFI..LDG.....GHR...FRDk16gpV..LFRRA.....FPDWNIVLAIP
  78 dDASASFYG.....GLT..VTD.....NME...RRI.....I..LREP-.....MENQKVLIYMP
  79 .GVASFEDG.....GFI..VDA.....GHS...SREk17pvI..ARYDF.....PEEWNIIIAIP
  80 .DVPFFLLG.....GAA..LAE.....GVG...ERL.....-..TPVDD.....LPPVHLVLANA
  81 .DVIAQYVK.....GFV..IRK.....TPG...FPI.....N..VEKIV.....VDDDYYIIIEI
  82 .DVPFSLVG.....GAA..LGT.....GRG...ERL.....-..AELEV.....GGDFHWVFALA
  83 .DQTASACCrg...GHA..LFL.....DTR...DLS.....Q..RQIPFdla..AEGMRLLVVDT
  84 .DVPFFLYG.....GTA..LVR.....GRG...EIV.....E..KLED-.....IEGYSVDLFFP
  85 .DIVAQLAG.....GIE..IRI.....KEG...GPG.....V..AVVDNi....LVEGFKVLTIS
  86 .DVPVFVHG.....CNA..WAE.....GVG...ECL.....T..PMI--.....LPGAAYLLLDP
  87 .DNTVSAYG.....N--..-MI.....KFC...SGE.....I..TRLQS.....NMPLRMLITNT
  88 dDASASMLG.....GFV..VSD.....NRK...MRL.....I..RTDE-.....-FEGYSAVLIP
  89 .DAPFFLLG.....KSA..IGR.....GKG...EVL.....-..EPVET.....EISGKITLVIP
  90 .DVPVFTRG.....RAA..FAE.....GVG...EKL.....-..TPVD-.....IPEPWYLVVVP
  91 .DNTVSAYG.....N--..-MI.....KFC...SGE.....I..TRLQS.....NMPLRMLITNT
  92 .DIPFFFSH.....GAA..YCT.....GRG...EVV.....Qd.IPSPI.....PFDIPMVLIKP
  93 .QGGLIVDG.....GFV..RGE.....RRP...PPL.....V..FRAHV.....PGSVKVVVALP
  94 .DHLAALFGap...KTA..LLI.....DFR...DIT.....V..RPVAFd....PDACDVVLLLM
  95 .DLIAEVTG.....GMV..IRT.....REG...PPG.....Y..GRVDRi....IQDGLHVITRT
  96 .GVAVFDHG.....GLV..VDG.....GHS...TKEk17pmI..ARLD-.....FPDWNVVLAIP
  97 .DIVAQLAG.....GVE..VRI.....KEG...GPG.....V..AIVDNl....IVEGFKVLTIS
  98 .DHYAAAFG.....GFN..FME.....SRP...NGE.....V..VVNPLri8iaELEASLLLYFG
  99 .DIPFFLSGy....KTA..YIS.....DYG...SVL.....E..DLTG-.....QFKLNYEVYLM
 100 dDACASYFG.....GLC..ITD.....NYE...MEI.....L..VKREI.....NPETVVLLIPR
 101 .DVTIAVRG.....G-V..LAY.....RRG...ENP.....V..DIRPG.....LTGVTLLVADT
 102 .SAARAIYG.....GFT..ILK.....EGS...KES.....F..QLRDQsy...FNDLRIIFAII
 103 .DHWTAASGaa7ri---..---ap8daRPD...PEL.....Y..EALGP.....LLDHRLLPCAP
 104 .DVPFFLAS.....QAA..CVL.....GGG...EQL.....V..PLVP-.....KTGYLGLLVWP
 105 .DQCASVCG.....---..---.....---...---.....-..-----.....-----------
 106 .DVPVFVRG.....HAA..FAE.....GVG...EIL.....T..PVDP-.....-PEKWYLVAHP
 107 .NI------.....---..---.....---...---.....-..-----.....-----------
 108 .DNAVATYG.....NAL..LFE.....KDS...HNGti6nnF..KFLDD.....FPAIPMILT--
 109 .DTNFFISQy....KST..NAT.....SYG...EVI.....E..NFEEE.....PLENRLEIYAP
 110 .--------.....---..---.....---...---.....-..-----.....-----------
 111 .DTNFFISQy....KSA..NAT.....SYG...EVI.....E..NFEEE.....SLEDRLEIYAP
 112 .DVPFFF--.....---..---.....---...---.....-..-----.....-----------


      180                190            200            210             
       |                  |              |              |             
   1 NISI.....NTKEARE....ILPKAVGLK.....DLVNNVGK.....ACGMV..YAL.....YNK
   2 NISI.....NTKEARE....ILPKAVGLK.....DLVNNVGK.....ACGMV..YAL.....YNK
   3 GIKV.....STAEARA....ILPAQYRRQ.....DCIAHGRH.....LAGFI..HAC.....YSR
   4 NVPHdl8ynTRRQQCE....EAAKFFGVKa29arHVVTENQR.....VLDAV..EAL.....KNN
   5 NVPHdl8ynTRRQQCE....EAAKFFGVKa29arHVVTENQR.....VLDAV..EAL.....KNN
   6 NVPHdl8ynTRRQQCE....EAAKFFGVKa29arHVVTENQR.....VLDAV..EAL.....KNN
   7 NKRRe12raECETAVS....ELQEKLDIQt27arHVVLENQR.....TLQAR..KAL.....ETG
   8 GIKV.....STAEARA....ILPAQYRRQ.....DCISHGRY.....LAGFI..HAC.....HTR
   9 NFKRt14qcETGARFF....QQPALRDVTi20vrHILTENAR.....TVEAA..SAL.....EQG
  10 NFKRt14qcETGARFF....QQPALRDVTi20vrHILTENAR.....TVEAA..SAL.....EQG
  11 NFKRt14qcETGARFF....QQPALRDVTi20vrHILTENAR.....TVEAA..SAL.....EQG
  12 NKKRt12rqECNDALL....DLKKGLDIAa27akHAVYENHR.....AIKTA..HMF.....KEN
  13 NNPHt12vaECGRALK....KLQQKLDIKa27arHAVSENQR.....TLRAT..QAM.....KDG
  14 NVKHe12rqECEEVLR....VLGKRSFREv18aqHVLEENER.....VLKSV..QAL.....KEG
  15 NVKHdl8ynSRRQECE....FAARFFGVKa29akHIISENQR.....VLEAV..EAL.....KAN
  16 NKRRe12rsECEKALA....MLQKGIEVKs27arHAVFENQR.....TLKAS..KAL.....QDG
  17 NKRRe12rsECEEALK....RLQTQLTIDa27arHAVTENQR.....TLEAK..AEL.....EKG
  18 FYEV.....LTRDARD....VLPKEFPYA.....DAVKASAV.....SNILI..AAI.....MSK
  19 EVEV.....PTKEARR....IVPEKVPLK.....DAIKNLAM.....ASSLV..LAL.....KEG
  20 NVKHe12rqECEEVLK....TLEKKSFREv18aqHVLEENER.....VLKSV..QAL.....KEG
  21 DFEV.....STSEARR....VLPKKVELK.....EAVFNVQR.....SALFV..SAL.....LTK
  22 FYEV.....LTRDARD....VLPKEFPYA.....DAVKASAV.....SNILI..AAI.....MSK
  23 GLKS.....RRQKQ-G....YLPAQYRRQ.....DCIAHGRH.....LAGFI..HAC.....YSR
  24 NKRRe12rtECEKAVE....ELNVLLDIKt27arHAVSENQR.....TLKAK..KAL.....AAG
  25 NKPRa12faETREALK....RMQTRLDIQs27arHAVYENNR.....TKIAQ..KAF.....VAG
  26 LAESq30gmEPKEAIS....KVKTLSDVEg68aaHVYSEARR.....VHGFK..DTVnsnlsDEE
  27 LAESq30gmEPKEAIS....KVKTLSDVEg68aaHVYSEARR.....VHGFK..DTVnsnlsDEE
  28 NKPRa12faETREALK....RMQTKLDIQs27arHAVYENNR.....TKIAQ..KAF.....VAG
  29 LAESq30gmEPKEAIS....KVKTLSDVEg68aaHVYSEARR.....VHGFK..DTVnsnlsDEE
  30 DFEA.....PTKKMRA....ALPTEIPMV.....HHVWNSSQ.....AAALV..AAV.....LEG
  31 GIEV.....STAEARA....ILPKSYTRQ.....NVIAHGRH.....LGGFV..HAC.....HTH
  32 NFHA.....STEAVRR....VLPTEVTHI.....DARFNVSR.....VAVMI..VAL.....QQR
  33 NFHA.....STEAVRR....VLPTEVTHI.....DARFNVSR.....VAVMI..VAL.....QQR
  34 EFEA.....PTKKMRA....ALPTEIPMV.....HHVWNSSQ.....AAALV..AAV.....LEG
  35 NRAI.....STKQSRH....LLPKRYSVQ.....ESVFNLSH.....ASLMT..MAI.....VQG
  36 GVRRe24kgSSKEVREg...ELSKLPPLHrkffgYIVRENAR.....VLEVR..DAL.....KEG
  37 NRVI.....STKQSRH....LLPKRYSVQ.....ESVFNLSH.....ASLMT..MAI.....VQG
  38 LAESq74epYTAEEIEk...ILEEKLPSIv24aaHVYSEARR.....VHGFK..DTVnsnlsDEE
  39 NKRRe12lkECQSALA....LLQQELDVDa27arHAITENAR.....VKEAH..AAL.....NRK
  40 QFEL.....STADSRG....VLPKAYPTQ.....DLVFNLQR.....LAVLT..TAL.....TMD
  41 NYEL.....RTRDSRS....VLPKKLSYK.....EAVAASSI.....ANVAV..AAL.....LAG
  42 QFEL.....STADSRG....VLPKAYPTQ.....DLVFNLQR.....LAVLT..TAL.....TMD
  43 NLAM.....STEQSRQ....ALAKNLSFN.....DAVFNLSH.....ASFLT..ACF.....LEK
  44 DFEL.....STSKARA....VLPREYSRA.....DTVHALSH.....AALLA..AAL.....AQG
  45 DYEL.....KTVESRK....VLPNELTYK.....EAVAASSI.....ANVLT..ASL.....LTN
  46 RVKHs32yaDLDAALE....RLGDEEEVRrlvr.HVVTEDER.....VERVV..ALL.....ESG
  47 DFEL.....STQEARR....VLPTEFSRA.....DAIFNTAH.....LGLLL..RGL.....ATG
  48 NFEL.....STEAARA....VLPHQYDRS.....AAIFNASH.....LALLV..QAF.....SQG
  49 NFPV.....CTNEMRK....ILPEKVPFE.....DAVFNIKN.....SCQFL..AKI.....AAG
  50 EFHL.....ATSKARS....VLPTSYGRT.....DVVYNLQR.....LALLT..TAL.....GQT
  51 PVHV.....STAKIFTh...---------.....--------.....-EGLT..RNS.....ASS
  52 GVSI.....PTPVIFKdp..ELPRNTP--.....--------.....-----..---.....-KR
  53 GSTG.....STKELVA....MVRKRYEEMp11amGKLVDKAK.....EIILS..KLD.....EEE
  54 SIEV.....STPWAYQ....TYRQKFGKNyl8sqRARRKTIH.....AGPLL..QGI.....QHR
  55 EVEI.....PTAKARK....ILPSMVPLK.....DAVKNIAM.....ASSLI..LAL.....KEG
  56 GVSI.....PTPVIFKdp..QLPRNTP--.....--------.....-----..---.....-KR
  57 SLQVs16vvEMAIAGD....LLAKKLNVEg94alHVYRESLR.....VLKTL..QLLstvvdASQ
  58 MNPVpqg..KTGVMRK....VLPENVSFR.....DAVRNFSR.....AAGIV..AAA.....VNG
  59 DTLL.....ETRRARE....VLKDPYLLP.....DIVTQSAN.....LALVL..AGC.....YHG
  60 SLQVs16vvEMAIAAD....VLVKKLNLGt95akHVYQESLR.....VLETL..KLLs12ddDES
  61 DDSI.....STAVIFQdp..NLPRNTPKK.....SLAQLLSEp....-----..---.....---
  62 DDSI.....STAVIFQdp..NLPRNTPKK.....SLAQLLSEp....-----..---.....---
  63 NITR.....EAKDIEEhkkgKLGDEKSLE.....AMHAIKQD.....AIKMK..EAL.....FRA
  64 PVHV.....STAKIFTh...---------.....--------.....-ESLT..RNS.....ASS
  65 FGSR.....STAEMVA....KVAELRERHp....EVVDKIFD.....AIDAIslEAS.....DVG
  66 EERS.....STAESRV....LLPARVSHD.....DARFNVSR.....AALLV..VAL.....TER
  67 GSSG.....STKELVA....MVRRRYEEMp11smGKLVDKAK.....EVIIS..KLD.....EEE
  68 EQRS.....STAETRV....LLPAQVSHD.....DARFNVSR.....AALLV..VAL.....TER
  69 DSGL.....LTSAVYN....ELDRLREVG.....DPPR-LGE.....PGPVL..AAL.....AAG
  70 TIGV.....STAEVYR....ALK------.....LDGIEHPD.....VQGMI..EAI.....EEK
  71 EKRKk....KTAELVN....EVAKIENKD.....EIFKEIDK.....VID--..EAL.....KIK
  72 KVKR.....GLSEEEEegi.MFGSNFGNV.....NIAKEITYrl...MLGLV..PSL.....IEK
  73 N---.....-------....-LEKNVDVN.....RMKLIKDY.....VEIAF..NEA.....ING
  74 RIPR.....STKDLVA....RVRVLVTEKf20glEIMTKLSK.....CKGTD..DEA.....VET
  75 KVKR.....GLSEEEEkdi.MFGSNFGKV.....EIAKEISHrl...LLGLI..PAL.....VER
  76 KGEHv....YGKKEVD....IFKKYCPVPl....NEVEKICHlv...LMKMM..PAV.....VEK
  77 NTKGv....HDAEEVD....IFKKACPIPl....SEVQEISHvi...LMQML..PAL.....IEE
  78 DRKS.....LTAQS--....------DVP.....RMKLLAPW.....VDMAF..REV.....LDG
  79 EIDRsv...SGRREVN....IFQEYCPLPl....RDVERLSHii...LMKMM..PAI.....LEG
  80 GAEV.....SAGDAYR....WLDETGDFSg....KLRLEAMR.....LAL--..---.....---
  81 FGKK.....ETKEIITn...---------.....DIWIKKIN.....EYGER..CLN.....ELL
  82 ARGL.....STPAVFR....EFDRLGEGL.....DLPEPVAD.....QAV-L..DAL.....AKG
  83 RVKHs32yaDLDAALE....RLGDEE---ev7vrHVVTEDER.....VERVV..ALL.....ESG
  84 GIHS.....STKEMYLs...LTPEMYR--.....---KGPGR.....VEELH..RAY.....LER
  85 IGKL.....ETRKVLDs...---------.....EVVEKIKI.....AGKQA..LEN.....LLR
  86 GVCV.....PTRELFL....DPDLTRDAS.....PATIGDFI.....AGTA-..---.....---
  87 RVGR.....NTKALVSg...VSQRAVRHP.....DAMKSVFN.....AVDSI..SKEl12tsVTE
  88 KFSR.....G------....----KVDWR.....RLRERASE.....VEGAV..EAA.....MRG
  89 QVSS.....STGRVYS....SLRE-----.....EHFVTPEY.....AEEKI..QRI.....ISG
  90 QVLV.....STAEIFSd...---------.....-PLLTRDS.....PAIKV..RTV.....LEG
  91 RVGR.....NTKALVSg...VSQRAVRHP.....DAMKSVFN.....AVDSI..SKEl12tsVTE
  92 QQAC.....STAEVYK....RFQ--LDLS.....SKVDPLSL.....LEKIS..TSG.....ISQ
  93 ERPIak8krREDELLA....RMPPMDPSM.....AGWASRVV.....LLGIM..ANA.....AEG
  94 DSRAr14raSCERAAA....DLGVSSLRAv22arHVLTENQR.....VLDFA..AAL.....ADS
  95 LGEL.....DTASVIH....------DDA.....HVRAINRM.....GGGMI..GRL.....LKR
  96 DLKGf....FGEREVN....LFQKSCPVPl....EDVREICHli...LMKML..PAV.....VEA
  97 LGRL.....STREVLDs...---------.....DVVEKIKV.....EGQKS..LEN.....LLA
  98 GVSR.....LSSEVIA....DQQRNVVERda6laATHSICAE.....ALEMK..DLL.....VVG
  99 NVNV.....NTKIVFE....KFDD--NSW.....HVIKNNFK.....TII--..---.....--K
 100 E---.....------T....VLTESLKGV.....DFSKISPF.....IGEAL..RLA.....ISG
 101 GVER.....RTRDVVEh...VLSIADALG.....EASTYIYRaadliAREAL..HAI.....EKG
 102 DSNEkel..SSRAAMN....ICKRHKFYY.....DAWIASSKki...FKDAL..YFF.....LKK
 103 PHTF.....RPTPLAA....QARALRGKR.....DMTHIQSL.....VDDVR..KAL.....VAA
 104 GLHS.....GSAQAYE....DLDRLRACGvhaa.DGEQYSLR.....GATAL..SAH.....YAQ
 105 ----.....-------....---------.....--------.....-----..---.....---
 106 GVSI.....PTPVIFKdp..ELPRNTPKR.....--------.....-----..---.....---
 107 ----.....-------....---------.....--------.....-----..---.....---
 108 ----.....-------....---------.....--------.....-----..---.....---
 109 NHVFc....STKAVYQay..KPETCFSQA.....KEWLKKPS.....LECLK..TYD.....RNG
 110 ----.....-------....---------.....--------.....-----..---.....---
 111 NHVFc....STKAVYQ....AYKPETCFF.....QAKEWLKK.....TSLEC..LKT.....YDR
 112 ----.....-------....---------.....--------.....-----..---.....---


       220                 230       240           250       260       
        |                   |         |             |         |       
   1 DKSLFGRYM.....MSDK.....VIEPVRGKLIPNYFKIKE....EVKDKVYGITISG..SG..P
   2 DKSLFGRYM.....MSDK.....VIEPVRGKLIPNYFKIKE....EVKDKVYGITISG..SG..P
   3 QPELAAKLM.....-KDV.....IAEPYRERLLPGFRQARQa...VAEIGAVASGISG..SG..P
   4 DLTCLGKLM.....EASHd....SMRDDFEITVPQIDYLVElaq.LVIGKSGGARMTGggFG..G
   5 DLTCLGKLM.....EASHd....SMRDDFEITVPQIDYLVElvq.LVIGKSGGTRMTGggFG..G
   6 DLTCLGKLM.....EASHd....SMRDDFEITVPQIDYLVElaq.LVIGKSGGARMTGggFG..G
   7 DLEGFGRLM.....NASHv....SLEYDYEVTGLELDTLAHta..WEQEGVLGARMTGagFG..G
   8 QPQLAAKLM.....-QDV.....IAEPYRTRLLPGFAEARKa...AQEIGALACGISG..SG..P
   9 DLKRMGELM.....AESHa....SMRDDFEITVPQIDTLVEivk.AVIGDKGGVRMTGggFG..G
  10 DLKRMGELM.....AESHa....SMRDDFEITVPQIDTLVEivk.AVIGDKGGVRMTGggFG..G
  11 DLKRMGELM.....AESHa....SMRDDFEITVPQIDTLVEivk.AVIGDKGGVRMTGggFG..G
  12 NIDEIGQLM.....KESHl....SLKDDYEVTCPELDELVFaa..WDHEGVIGSRMTGagFG..G
  13 DLEKLGRLI.....NASHe....SLHYDYEVTGKELDTLAEas..WKQPGVLGARMIGggFG..G
  14 DFETLGRLL.....FSSHe....SLRDLYEVSCEQTDFIVDfl..KGREGILGARMVGggFG..G
  15 DMVKLGQLM.....AGSHd....SMRDDFEITIPEIDYLVElaq.VAIGKNGGARMTGggFG..G
  16 DLKTFGKLV.....SASGv....SLAFDYEVTGIELDTLVTna..LKQRGVLGARMTGagFG..G
  17 NLAAFGKLL.....NASHy....SLRHDYEVTGIELDTLVDaa..QKQEGVLGARMTGagFG..G
  18 DWPLVGKIM.....KKDM.....FHQPYRAMLVPELSKVEHv...AEMKGAYGTALSG..AG..P
  19 DIETVGRLL.....-DDN.....LALPYRKKLMPWFDEVRKa...GLEAGAYGVTVSG..SG..P
  20 DFETLGKLL.....FSSHe....SLRDLYEVSCEETDFIVDyl..RGKEGILGARMVGggFG..G
  21 DYKLLREAV.....-RDK.....LHQPYREKLVPGLSEAILv...SYKEGALATFLSG..AG..P
  22 DWPLVGKIM.....KKDM.....FHQPYRAMLVPELSKVEHv...AEMKGAYGTALSG..AG..P
  23 QPELAAKLM.....-KDV.....IAEPYRERLLPGFRQARQa...VAEIGAVASGISG..SG..P
  24 DLEKFGRLV.....NASHv....SLEHDYEVTGIELDTLAHta..WEQEGVLGARMTGsgFG..G
  25 NLTKFGELL.....NASHa....SLKDDYEVTGLELDTLAEta..QKQAGVLGARMTGagFG..G
  26 KLKKLGDLM.....NESHy....SCSVLYECSCPELEELVQv...CKENGALGARLTGagWG..G
  27 KLKKLGDLM.....NESHy....SCSVLYECSCPELEELVQv...CKENGALGARLTGagWG..G
  28 NLTKFGELL.....NASHa....SLKDDYEVTGLELDTLAEta..QKQAGVLGARMTGagFG..G
  29 KLKKLGDLM.....NESHy....SCSVLYECSCPELEELVQv...CKENGPLGARLTGagWG..G
  30 DAVMLGKAL.....SSDK.....IVEPTRAPLIPGMEAVKKa...ALEAGAFGCTISG..AG..P
  31 QENLAAIMM.....-KDV.....IAEPYRESLLPNFAEVKQa...TRDLGALATGISG..SG..P
  32 PDLLWEGTR.....--DR.....LHQPYRAEVLPVTSEWVN....RLRNRGYAAYLSG..AG..P
  33 PDLLWEGTR.....--DR.....LHQPYRAEVLPITSEWVN....RLRNRGYAAYLSG..AG..P
  34 DAVMLGKAL.....SSDK.....IVEPTRAPLIPGMEAVKKa...ALEAGAFGCTISG..AG..P
  35 KWDLLRCCS.....-KDR.....MHQYKRMQTYPVLFAIQKi...ALENNALMSTLSG..SG..S
  36 NVEEVGKIL.....TTAHw....DLAKNYEVSCKELDFFVEr...ALKLGAYGARLTGagFG..G
  37 KWDLLRCCS.....-KDR.....MHQYKRMQTYPVLFAIQKl...ALENNALMSTLSG..SG..S
  38 KLKKLGDLM.....NETHy....SCSVLYECSCPELEELVQv...CKENGALGARLTGagWG..G
  39 DFIEFGRLL.....NASHa....SLKNDYEVTGIELDTLAEta..QQVEGVLGARMTG..AGfaG
  40 PPNADLIYPa....MQDR.....VHQPYRKTLIPGLTEILScvtpSTYPGLLGICLSG..AG..P
  41 DMVTAGQAI.....EGDL.....FHERYRQDLVREFAMIKQv...TKENGAYATYLSG..AG..P
  42 PPNADLIYPa....MQDR.....VHQPYRKTLIPGLTEILScvtpSTYPGLLGICLSG..AG..P
  43 KYEFLKFAS.....-QDK.....LHEINRMKNLPELFEVQKf...ALENKALMSTLSG..SG..S
  44 RLDLLRHAM.....-QDY.....VHQVWRAPLVPGLSDILEh...AHEYGALGAALSG..AG..P
  45 NLEVAGQMM.....EADR.....FHESYRASLIPELQLLREi...GHEFGAYGTYLSG..AG..P
  46 DTRAIGAVL.....VEGHa....SLRDDFRISCPELDLVVDt...ALASGALGARMTGggFG..G
  47 KGEWLKTAL.....-QDK.....LHQPYRKALIPGYDAVNQa...AVAAGAYGMVISG..AG..P
  48 RGDWLALAL.....-QDQ.....IHQPYRQSLIPAYDQLHQa...ALAAGAYNLVISG..AG..P
  49 KIKEALKYV.....-GDR.....LHQNYRINGNKKMKEFVEa...ILSKNPEYWFVSG..SG..P
  50 PINPHLVYEv....MKDK.....VHQPYRASLIPGLQNILAtlnpDTQPGLCGICLSG..AG..P
  51 IMPTFQNLQ.....PFRN.....DMQAVVFKEYPEVWKAYS....ELSRYGF-ALMTG..SG..A
  52 SIETLLKCE.....-FSN.....DCEVIARKRFREVDAVLS....WLLEYAP-SRLTG..TG..A
  53 KLTKLGELM.....NINH.....GLLDALGVSTKKLGELVYa...ARTAGAIGAKLTGagGG..G
  54 NPGQIASHI.....--HN.....DLEKVVLPAHQPVAQLRQv...LQSAGGLGTMMSG..SG..P
  55 DLETIGRLL.....-DDN.....LALPYRKKLMPWFDEIRRv...ALETGAYGITVSG..SG..P
  56 SIDTLLKCE.....-FSN.....DCEVIARKRFREVDAALS....WLLEYAP-SRLTG..TG..A
  57 FLQTFGSLM.....NESQh....DLDILNESSNPKLNEICSi...ALANGAYGSRVTGagWG..G
  58 DLKSMGALM.....MSDE.....IVEPRRRSYVPCYTQVRKa...ALQAGALGFSLSG..AG..P
  59 DAELVRAGL.....-RDV.....LIEPRRAPLIAGFTAAQQa...ALQADAMGASISG..AG..P
  60 FLVKFGELM.....NQSQs....DLDKLNESSNDKLNKICSi...ALQNGSYGSRITGagWG..G
  61 ---------.....-YKN.....DCEKVVINHYSNVEKALN....WLLQYAP-ARLTG..TG..A
  62 ---------.....-YKN.....DCEKVVINHYSNVEKALN....WLLQYAP-ARLTG..TG..A
  63 DFGTLAQIL.....GKSWrs...KKIISEIVSNDELERIYKl...AIDNGAYSGKTSGagAG..G
  64 IMPTFQNLQ.....PFRN.....DMQAVVFKEYPEVWKAYS....ELSRYGF-ALMTG..SG..A
  65 SAERLEELI.....AINQ.....SLLRAIGVSNPEIDRTIA....ELERMGLNAKITGagGG..G
  66 PDLLMAATE.....--DV.....LHQPHRASAMSASAEYLR....LLRRHNVAATLSG..AG..P
  67 KFLKLGELM.....NINH.....GLLDALGVSTKKLSELVYa...ARTAGAIGAKLTGagGG..G
  68 PDLLMAATE.....--DL.....LHQPQRAAAMTASAEYLR....LLRRHNVAAALSG..AG..P
  69 DPDQLAPLL.....--GN.....EMQAAAVSLDPALARALRa...GVEAGALAGIVSG..SG..P
  70 SFQKMCSRL.....--GN.....VLESVTLDMHPEVAMIKNq...MKRFGADAVLMSG..SG..P
  71 NKEDFGKLM.....TKNH.....ELLKKLNISTPKLDRIVD....IGNRFGFGAKLTGagGG..G
  72 NIEKFGRFLtd6elVGKH.....FATFQGGTFREDIKTVVE....ILKETTYGAGQSS..WG..P
  73 NYFKALFLN.....----.....-GILYASALNFPTNIAID....ALDAGAITAGLSG..TG..P
  74 NNELYEQLLeli..RINH.....GLLVSIGVSHPGLELIKNl...SDDLRIGSTKLTGagGG..G
  75 DIESFGRFLse6elVGSH.....FSTFQGGTFREDIGIIVE....ILKELTYGAGQSS..WG..P
  76 NLDDFGEVI.....NKLQyl...GFKKVELSLQSDIVKDLIn...ELHKDVY-AGLSS..FG..P
  77 DIDSFGRAV.....NHFQtv...GFKKREVELQPETVLNVMky..MQDNGASGSGVSS..FG..P
  78 RVHSALTLN.....----.....-GILYCASLGFDPGIALD....ALEAGALAAGLSG..TG..P
  79 DIEAFGESV.....NEIQgtg..FKRIERELQDPLIDRIIDs...MISAGAPGAGMSS..FG..P
  80 ---ARGVEV.....PYFN.....SLQAGVLARVPSVLTTLEa...LADAGLHSVLMSG..SG..A
  81 KNPTLENFV.....NLSY.....EFAVNTGLINEKILSICE....DLKFTVG-ASQSM..LG..N
  82 DAAALAVAV.....--TN.....DLQPAALSLFPELSDTLAa...GRAAGALAALVSG..SG..P
  83 DTRRIGAVL.....VEGHa....SLRDDFRISCPELDLVVDt...ALASAALGRRMTGggFG..G
  84 NYEKIKELS.....--YN.....VFEKVFLEKHPEVMDGLR....NFGDGSIVKMMTG..SG..S
  85 DP-RPETLM.....KEAR.....SFAVETGLMSEDLIEIANe...IDREISLPSSMIM..LG..K
  86 ---------.....-FGN.....AFEPVLRRRESAVAGALD....VLSEVGF-ARVTG..SG..S
  87 KEERIKELM.....EMNQ.....GLLLSMGVSHSSIEAVIL....TTVKHKLVSKLTGagGG..G
  88 EYCKAMKLN.....----.....--TEYICKMLGYPLEIAE....KGWEKGICCGISG..NG..P
  89 EVEEI----.....--EN.....VLGDIARELYPEINEVYR....FVEYLGFKPFVSG..SG..S
  90 D--------.....-SRN.....DCQPVVERRYPE------....-------------..--..-
  91 KEERIKELM.....EMNQ.....GLLLSMGVSHSSIEAVIL....TTVKHKLVSKLTGagGG..G
  92 DV-------.....-CVN.....DLEPPAFEVLPSLKRLKQrviaAGRGQYDAVFMSG..SG..S
  93 RWGEAARWM.....GEFNrr7ywAGEQGGIYCCSEVEEIVRa...MVDAGAWSGLQSS..WG..P
  94 DFTAAGQLL.....TASHe....SMREDFAITTERIDLIAEs...AVRAGALGARMTGggFG..G
  95 P--APARFM.....ELSR.....EFAEGAGLIPRELREPLE....ELSEGTLGASMAM..LG..N
  96 DLDEFGKAL.....-KRI.....QELGFKKAEVEQYGELIK....GCFDLADCIGMSS..TG..P
  97 NP-TLETLM.....REAR.....RFAEVTGLMDDELKEIARe...VDKVISLPSSMIM..LG..K
  98 DIPGFADSL.....LRGWqa...KKRTSTRISNPAIEHAYQv...AQSSGMVAGKVSG..AG..G
  99 NLKENIVVN.....-IHN.....DLQEYCFELYPNIKYKYN....ELLSDGFYTILSG..AG..S
 100 EWKKALVIN.....----.....-GLLYSTFLGYDLAPMRE....ALKLGAF-VGLCG..KG..P
 101 DAERLGLIM.....NAAQ.....GLLSSLGASSLEIETLVYr...MRSAGALGAKLTGagWG..G
 102 DFIHFGATI.....VKSYqn9faSSIFYFKNSTIDLIRYAA....DLRNEGIFVFETMd.AG..P
 103 DIARVGALL.....HEHWta...KRAVSDAMSTPEIDRWYAm...VRDHGAYGAKLVG..AG..G
 104 DCARWRFFN.....----.....SLDAPVQRRYPVVALARWd...LARAGACFTAMSG..SG..S
 105 ---------.....----.....------------------....-------------..--..-
 106 ---------.....----.....------------------....-------------..--..-
 107 ---------.....----.....------------------....-------------..--..-
 108 ---------.....----.....------------------....-------------..--..-
 109 LNDLLKPAL.....LTNQ.....ALKDIESELGKE------....--------WFFSG..SG..S
 110 ---------.....----.....------------------....-------------..--..-
 111 N--------.....-ELN.....DLLKPALRTNPALKDIES....QLSKEWF---FSG..SG..S
 112 ---------.....----.....------------------....-------------..--..-


          270              280       290       300
           |                |         |         |
   1 SIIAFPKE....E.FIDEV.E.NILRDYYENTIRTEVGKGVEVV
   2 SIIAFPKE....E.FIDEV.E.NILRDYYENTIRTEVGKGVEV-
   3 TLFALCDK....P.--ETA.Q.RVADWLGKNYLQNQEGFVH---
   4 CIVALAPH....D.KVDSV.R.KIIADNYEKTTGLKETFYV---
   5 CIVALAPH....D.KVDAV.R.KIIADNYEKTTGLKETFYV---
   6 CIVALAPH....D.KVDSV.R.KIIADNYEKTTGLKETFYV---
   7 CAIALVNK....D.KVEDF.K.KAVGQRYEEVVGYAPSFYI---
   8 TLFAVCND....G.--ATA.Q.RMAAWLQQHYLQNDEGFVH---
   9 CIVALIPE....E.LVPAV.Q.QAVAEQYEAKTGIKETFYV---
  10 CIVALIPE....E.LVPAV.Q.QAVAEQYEAKTGIKETFYV---
  11 CIVALIPE....E.LVPAV.Q.QRVAEQYEAKTGIKETFYV---
  12 CTISIVKD....E.FVDDF.I.QKVGDRYQEKTGLRADFYV---
  13 SAIAIVKK....S.EAENF.K.KNVGKIYRDAVGYDASFY----
  14 GVIVLSKK....G.AFEKI.K.EELKNAYRDRFKIELTF-----
  15 CIVCLVPD....E.KVEHL.R.RIIADNYEKQTGIKETFH----
  16 CAIAIVNS....A.DVEDF.I.DNVGKTYREKIGYDAHFYV---
  17 CAIALVKE....E.NIPEF.E.NNVYDAYLKVIGYAPEFYV---
  18 TILVMTEK....G.KGEEL.K.EQLA------------------
  19 SLFAIGEN....-.-LKDI.G.KAMKEKF---------------
  20 GVIVLSKK....G.AFGKI.K.EELVESYRKRFGID--------
  21 TICSLTTE....N.-EEKI.G.EAIREVITKFSGYDAQV-----
  22 TILVMTEK....G.KGEEL.K.EQLA------------------
  23 TLFALCDK....P.--ETA.Q.RVADWLGKNYLQNQEGFVH---
  24 CGIAIVAK....D.KVAAL.K.ENVGRIYTETVGYAPRFY----
  25 CAIALVAH....D.NVSAF.E.KAVGQVYEEVVGYPASFYV---
  26 CAVALVKE....F.DVTQF.I.PAVKEKYYK-------------
  27 CAVALVKE....F.DVTQF.I.PAVKEKYYK-------------
  28 CAIALVAH....D.NVSAF.E.KAVGEVYEEVVGYPASFYV---
  29 CAVALVKE....F.DVTQF.I.PAVKEKYYK-------------
  30 TAVAVIDS....E.EKGQV.-.----------------------
  31 TIFSIAPD....-.-LQTA.I.KLSSYLESHYLQNNEGF-----
  32 TAMVLSTE....P.IPDKV.L.EDARESGIKVLELEVAGPV---
  33 TAMVLSTE....P.IPDKV.L.EDARESGIKVLELEVAGPV---
  34 TAVAVIDS....E.EKGQV.-.----------------------
  35 SFFNMCYE....E.DAPKL.K.QVLSKKFPK-------------
  36 SAIALVDK....E.DAETIgE.EILREYLKRFPWKARHF-----
  37 SFFNMCYE....E.DAPKL.K.QVLSKKFPK-------------
  38 CAVALVKE....F.DVTQF.I.PAVKEKYH--------------
  39 CAIALVHK....D.RIKDL.E.EEVTKIYKDKIGYEPSFYH---
  40 TILALATE....N.FEEIS.Q.EIINRFAKNGIKCSWK------
  41 TVMVLASH....D.KMPTI.K.AELEKQ----------------
  42 TILALATE....N.FEEIS.Q.EIINRFAKNGIKCSWK------
  43 SFFSLAFK....D.DALAL.A.KKIQTKFKD-------------
  44 TVLCFH--....-.-----.-.----------------------
  45 TVMLLVPD....D.KLTLL.T.E---------------------
  46 SAIVLVEA....A.GVDAV.T.KAVED-----------------
  47 TLLALADA....Q.N----.-.----------------------
  48 TLLAIADE....V.R----.-.----------------------
  49 SVCSNIND....-.-----.-.----------------------
  50 TVLALATG....N.FDEIA.H.AMLSIFEKHGVKC---------
  51 CVFTACQDr...N.SAYNI.Y.RQVSDLYEAY------------
  52 CVFAEFDT....E.--SEA.R.QVLEQAPE--------------
  53 CMYALAPG....R.-----.-.----------------------
  54 SVFTLCRE....Q.--AEA.E.QVLAIAKEKLNDPDVDFW----
  55 ALFAIGEN....-.-----.-.----------------------
  56 CVFAEFDT....E.S----.-.----------------------
  57 SIVHLTTT....E.NLPKL.T.KSLEAYYK--------------
  58 SMIALAPS....S.--EAA.R.EIAAAMEESCICCDNPM-----
  59 SVFAWFQT....R.-----.-.----------------------
  60 SIVHLTTL....D.KSKQL.I.QG--------------------
  61 CVFAEFDH....E.--AEA.Q.AVFRQKPEAFFG----------
  62 CVFAEFDH....E.--AEA.Q.AVFRQKPEAFFG----------
  63 FMFFFVDP....T.KKYNL.I.KALRKEQGYVQD----------
  64 CVFTACQDr...N.SAYNI.Y.RQVSDLYEAY------------
  65 CIFGLFKG....E.K----.-.----------------------
  66 SLIALSTQ....S.EL---.-.----------------------
  67 CMYALAPG....K.-----.-.----------------------
  68 SLIALSTD....S.EL---.-.----------------------
  69 TCAFLCT-....-.-----.-.----------------------
  70 TVFGLVQY....E.--SKV.Q.R---------------------
  71 CVIILVNE....E.KEKEL.L.KELNKEDVRIFNC---------
  72 TVYGLIRK....E.EYNSV.R.VKVADLLDDY------------
  73 SYIAMVED....E.NVEKV.K.EKLNRYGKVILTKPNNDG----
  74 CSLTLLRR....D.ITQEQ.I.DSFKKKLQDDFS----------
  75 TVYGLIKK....E.EFNLV.KtKV--------------------
  76 TIYAFGDKklivE.KANDI.F.DKYGVYGEIIITKANNVGHKIW
  77 VVYGIVES....SvEAGRL.Q.KEVQRMLDESLG----------
  78 SFVALTHE....D.SEADI.I.DAWENLEGDV------------
  79 AVYSVTDE....-.-----.-.----------------------
  80 TCFGLAHD....-.-----.-.----------------------
  81 TLFCISKK....E.TLEDA.L.SIL-------------------
  82 TTAFLATD....-.-----.-.----------------------
  83 SAIVLVEA....A.AVDAV.T.KAVED-----------------
  84 VFFALYP-....-.-----.-.----------------------
  85 GIFALVRE....E.EVEKV.K.EIVKDLD---------------
  86 GCFVEFST....R.D----.-.----------------------
  87 CVLTLLPT....GtVVDKV.V.EEL-------------------
  88 SYVAFGSK....N.EMEAL.A.ETWGEYGRVY------------
  89 TVYFFGGA....S.--EEL.K.KAAKMRGWKVV-----------
  90 --------....-.-----.-.----------------------
  91 CVLTLLPT....GtVVDKV.V.EEL-------------------
  92 TIVGVGSP....D.-----.-.----------------------
  93 TVYGLTPA....R.RAASV.L.EAARRAVERVGGG---------
  94 AVIALVPA....D.RARDV.A.DTVR------------------
  95 TVFALSED....P.D----.-.----------------------
  96 TVYAITDS....N.-AGGI.E.RSLRD-----------------
  97 GIFAMVRN....E.EVERV.K.ELVKDLGV--------------
  98 GGF-----....-.-----.-.----------------------
  99 SFIRIKLK....N.KEDL-.-.----------------------
 100 AFFAIADE....P.--EEI.I.EAWSSF----------------
 101 CVIGLFKE....G.EVERG.L.----------------------
 102 QVKFLCLE....E.NLNTI.L.KGLKQ-----------------
 103 GGHLLVAT....E.-----.-.----------------------
 104 XVFGLYRD....E.--EEL.R.RAHKLLAKRWC-----------
 105 --------....-.-----.-.----------------------
 106 --------....-.-----.-.----------------------
 107 --------....-.-----.-.----------------------
 108 --------....-.-----.-.----------------------
 109 AFFRLK--....-.-----.-.----------------------
 110 --------....-.-----.-.----------------------
 111 AFFRLKNT....-.-----.-.----------------------
 112 --------....-.-----.-.----------------------