; SAM: prettyalign v3.1b (February 24, 1999) compiled 04/18/00_11:44:15 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ------ Citations (HMMs, SAM) ------ ; A. Krogh et al., Hidden Markov models in computational biology: ; ------------- Citations (SAM, SAM-T99, HMMs) ----------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; -------------------------------------------------------------- ; Sequence numbers correspond to the following labels: ; 1 gi|82096|pir||A25010_3:272 ; 2 gi|3342904|gb|AAC27719.1|_273:571 ; 3 gi|7447387|pir||T02184_273:573 ; 4 gi|6093122|emb|CAB58974.1|_280:580 ; 5 gi|7447386|pir||T02183_280:580 ; 6 gi|6899927|emb|CAB71877.1|_272:572 ; 7 gi|1172538|sp|P41510|PME_BRANA_268:568 ; 8 gi|6093741|sp|Q42608|PME_BRACM_255:555 ; 9 gi|7671413|emb|CAB89354.1|_237:532 ; 10 gi|1552379|emb|CAA69348.1|_93:361 ; 11 gi|7447382|pir||T12995_277:564 ; 12 gi|6688852|emb|CAB65291.1|_245:529 ; 13 gi|6093742|sp|Q42920|PME_MEDSA_127:411 ; 14 gi|6688851|emb|CAB65290.1|_227:517 ; 15 gi|7447384|pir||T04359_247:531 ; 16 gi|6093743|sp|Q43043|PME_PETIN_54:335 ; 17 gi|1084429|pir||S46296_2:219 ; 18 gi|7447385|pir||T09823_2:215 ; 19 gi|7529744|emb|CAB86929.1|_224:496 ; 20 gi|4531441|gb|AAD22126.1|AC006224_8_210:484 ; 21 gi|6093736|sp|Q43867|PME1_ARATH_276:554 ; 22 gi|100010|pir||S25172_2:215 ; 23 gi|6093739|sp|Q43111|PME3_PHAVU_270:547 ; 24 gi|6630559|gb|AAF19578.1|AC011708_21_253:531 ; 25 gi|7447369|pir||T00977_235:519 ; 26 gi|6554203|gb|AAF16649.1|AC011661_27_43:298 ; 27 gi|5734773|gb|AAD50038.1|AC007980_3_155:344 ; 28 gi|2895512|gb|AAC02973.1|_2:78 ; 29 gi|6554191|gb|AAF16637.1|AC011661_15_1:193 ; 30 gi|7447391|pir||T01870_214:507 ; 31 gi|6554192|gb|AAF16638.1|AC011661_16_213:522 ; 32 gi|7767677|gb|AAF69174.1|AC007915_26_55:217 ; 33 gi|7447390|pir||T05203_292:581 ; 34 gi|7447376|pir||T00978_179:467 ; 35 gi|6714532|dbj|BAA89480.1|_283:571 ; 36 gi|7549630|gb|AAF63815.1|_247:542 ; 37 gi|7485174|pir||G71425_387:675 ; 38 gi|6714449|gb|AAF26136.1|AC011620_12_251:540 ; 39 gi|6723392|emb|CAB66401.1|_280:565 ; 40 gi|5922617|dbj|BAA84618.1|_300:579 ; 41 gi|6714448|gb|AAF26135.1|AC011620_11_238:514 ; 42 gi|7447388|pir||T01347_162:444 ; 43 gi|6554190|gb|AAF16636.1|AC011661_14_265:350 ; 44 gi|2895516|gb|AAC02975.1|_2:73 ; 45 gi|1932927|gb|AAB51702.1|_2:98 ; 46 gi|5566252|gb|AAD45348.1|_1:75 ; 47 gi|6093737|sp|Q42534|PME2_ARATH_267:551 ; 48 gi|6056392|gb|AAF02856.1|AC009324_5_272:556 ; 49 gi|1932925|gb|AAB51701.1|_2:84 ; 50 gi|2895510|gb|AAC72288.1|_277:561 ; 51 gi|6174912|sp|O04886|PME1_CITSI_269:555 ; 52 gi|7447380|pir||T10492_269:555 ; 53 gi|7488907|pir||T10488_46:261 ; 54 gi|6048277|emb|CAB57457.2|_2:255 ; 55 gi|6689892|gb|AAF23892.1|AF152172_1_261:546 ; 56 gi|6093740|sp|Q43143|PMEU_LYCES_268:553 ; 57 gi|7447389|pir||T01418_218:503 ; 58 gi|7447365|pir||T01318_203:489 ; 59 gi|7025485|gb|AAF35897.1|AF229849_1_1:246 ; 60 gi|2583131|gb|AAB82640.1|_202:479 ; 61 gi|7447381|pir||T10494_198:481 ; 62 gi|6174914|sp|O04887|PME2_CITSI_198:481 ; 63 gi|7447370|pir||T00429_153:439 ; 64 gi|6056422|gb|AAF02886.1|AC009525_20_263:548 ; 65 gi|2895514|gb|AAC02974.1|_2:78 ; 66 gi|7447366|pir||T01317_257:542 ; 67 gi|6630558|gb|AAF19577.1|AC011708_20_300:583 ; 68 gi|7329683|emb|CAB82677.1|_192:465 ; 69 gi|2829892|gb|AAC00600.1|_247:525 ; 70 gi|7649367|emb|CAB89048.1|_212:494 ; 71 gi|5566248|gb|AAD45347.1|_2:96 ; 72 gi|6093744|sp|Q43062|PME_PRUPE_205:492 ; 73 gi|7447375|pir||T05202_161:445 ; 74 gi|7447372|pir||T06468_237:523 ; 75 gi|7447371|pir||T06374_237:523 ; 76 gi|7447368|pir||S72525_2:285 ; 77 gi|7447367|pir||S78456_3:289 ; 78 gi|100008|pir||S25171_2:217 ; 79 gi|7447362|pir||T07181_1:216 ; 80 gi|7489092|pir||T16977_5:247 ; 81 gi|7489091|pir||T16976_1:288 ; 82 gi|7489090|pir||T16975_1:288 ; 83 gi|6093738|sp|Q96576|PME3_LYCES_228:512 ; 84 gi|7489089|pir||T16974_5:183 ; 85 gi|7447363|pir||T07183_2:219 ; 86 gi|6689890|gb|AAF23891.1|_213:498 ; 87 gi|1256267|gb|AAB67740.1|_113:398 ; 88 gi|6174913|sp|P14280|PME1_LYCES_229:514 ; 89 gi|1617588|gb|AAB38794.1|_122:407 ; 90 gi|6093734|sp|Q96575|PM22_LYCES_234:518 ; 91 gi|1256263|gb|AAB67739.1|_234:518 ; 92 gi|2507165|sp|P09607|PM21_LYCES_234:518 ; 93 gi|82097|pir||S00629_58:342 ; 94 gi|7670030|dbj|BAA94984.1|_42:326 ; 95 gi|7485253|pir||T01761_30:231 ; 96 gi|2275206|gb|AAB63828.1|_14:226 ; 97 gi|7488000|pir||T00536_37:321 ; 98 gi|2388565|gb|AAB71446.1|_87:370 ; 99 gi|4415916|gb|AAD20147.1|_87:372 ; 100 gi|4415915|gb|AAD20146.1|_38:321 ; 101 gi|4567229|gb|AAD23644.1|AC007119_10_47:320 ; 102 gi|7576180|emb|CAB87931.1|_63:347 ; 103 gi|7576181|emb|CAB87932.1|_63:347 ; 104 gi|6358800|gb|AAF07380.1|AC010675_3_50:324 ; 105 gi|7576179|emb|CAB87930.1|_46:328 ; 106 gi|130346|sp|P07863|PMEA_ERWCH_26:366 ; 107 T0100 ; 108 gi|478290|pir||JN0799_26:366 ; 109 gi|130347|sp|P24791|PME_BURSO_75:394 ; 110 gi|2121037|pir||S70913_20:179 ; 111 gi|2499455|sp|P55743|PMEB_ERWCA_3:156 ; 112 gi|2499456|sp|Q47474|PMEB_ERWCH_84:408 ; 113 gi|4062339|dbj|BAA35436.1|_45:388 ; 114 gi|2507166|sp|P46130|YBHC_ECOLI_77:420 ; 115 gi|5442422|gb|AAD43340.1|AF159252_1_35:331 ; 116 gi|5802953|gb|AAD51853.1|AF178989_1_34:329 ; 117 gi|2499454|sp|Q12535|PME_ASPAC_25:325 ; 118 gi|130345|sp|P17872|PME_ASPTU_25:324 ; 119 gi|4514622|dbj|BAA75474.1|_25:324 10 20 30 40 50 | | | | | 1 ---ANAVVAQDGTG--DYQTLAEAVAAAPDKSk...TRYVIYVKRGTYKEN.VEVAsnKEFPTYL 2 -VRTNFVVAKDGSG--QFKTVQQAVDACPENNr...GRCIIYIKAGLYREQ.VIIPkkKNNIFMF 3 -VRTNFVVAKDGSG--QFKTVQQAVDACPENNr...GRCIIYIKAGLYREQ.VIIPkkKNNIFMF 4 -IRATFVVAKDGSG--QFKTVQQAVNACPEKNp...GRCIIHIKAGIYREQ.VIIPkkKNNIFMF 5 -IRATFVVAKDGSG--QFKTVQQAVNACPEKNp...GRCIIHIKAGIYREQ.VIIPkkKNNIFMF 6 KIKATHVVAKDGSG--QFKTISEAVMACPDKNp...GRCIIHIKAGIYNEQ.VRIPkkKNNIFMF 7 KIKPTHVVAKDGSG--QFKTISEAVKACPEKNp...GRCIIYIKAGVYKEQ.VTIPkkVNNVFMF 8 KIKPTHVVAKDGSG--QFKTISEAVKACPEKNp...GRCIIYIKAGVYKEQ.VTIPkkVNNVFMF 9 -LKEDVTVCKDGKC--GYKTVQDAVNAAPEDNgm..RKFVIKISEGVYEEN.VIVPfeKKNVVFI 10 --------------------------------kgg.DRFVIRIKEGVYEET.VRAGfyKTNLVFL 11 -SSPHLVVAQDRSG--HFRSIQAAINFAARRRfk..SRFVIYVKKGVYREN.IDVGndNHNIMLV 12 NVKANAVVAQDGSG--QFKTLTDALKTVPPTNa...APFVIYVKAGVYKET.VNVAkeMNYVTVI 13 NVQPNAVVAQDGSG--QFKTLTDALKTVPPKNa...VPFVIHVKAGVYKET.VNVAkeMNYVTVI 14 TVKPNVVVAQDGSG--QFKTLTDAIKTVPANNa...QNFVIYVKEGVYNET.VNVPkdMAFVTII 15 QPKPNAIVAKDGSG--QFKSIQQAVDAVPKGHq...GRYVIYVKAGLYDEI.VMVPkdKVNIFMY 16 NAKPNATVALDGSG--QYKTIKEALDAVPKKNt...EPFIIFIKAGVYKEY.IDIPksMTNVVLI 17 ------TVALDGSG--QYKTIKEALDAVPKKNt...EPFIIFIKAGVYKEY.IDIPksMTNVVLI 18 ------VVAKDGTG--NFQTVKEAMDAAD-GK....KRFVIYVKAGVYKEK.IHSN..KDGITLI 19 ELRPHAVVAADGSG--THMSVAEALASLEKGS....GRSVIHLTAGTYKEN.LNIPskQKNVMLV 20 -LNVDAVVAPDGSG--THKTIGEALLSTSLASsg..GRTKIYLKAGTYHEN.INIPtkQKNVMLV 21 GLKPDVTVAGDGTG--DVLTVNEAVAKVPKKSl...KMFVIYVKSGTYVEN.VVMDksKWNVMIY 22 ------VVAKDGSG--QFKTIGEALKLVKKKSe...KRFSVYVKEGRYVEN.IDLDknTWNVMIY 23 -STPDAVVAKDGSG--QFKTIGEALKLVKKKSe...ERFSVYVKEGRYVEN.IDLDknTWNVMIY 24 --VADIVVAKDGSG--KYRTIKRALQDVPEKSe...KRTIIYVKKGVYFEN.VKVEkkMWNVIVV 25 --SESLVVAADGTG--NFSTINEAISFAPNMSn...DRVLIYVKEGVYDEN.IDIPiyKTNIVLI 26 --KADLIVAKDGSG--NFTTVNEAVAAAPENGv...KPFVIYIKEGLYKEV.IRIGkkKTNLTLV 27 --------------------------------....---------------.----..------- 28 --------------------------------....---------------.----..------- 29 --------------------------------....---------------.----..------- 30 --IADVVVAKDGTG--KYNTVNAAIAAAPQHSh...KRFIIYIKTGIYDEI.VAIEntKPNLTLI 31 --IADVVVAKDGTG--KYSTVNAAIAAAPQHSq...KRFVIYIKTGIYDEI.VVIEntKPNLTLI 32 --ITDILVAKDVTG--NYNIVNVAIAAAPQHSq...KRFVIYIKTSIYVEI.VVIGnmKSNLTLI 33 ALKPNATVAKDGSG--NFTTINAALKAMPAKYq...GRYTIYIKHGIYDES.VIIDkkKPNVTMV 34 ALKPNATVAKDGSG--DFTTINDALRAMPEKYe...GRYIIYVKQGIYDEY.VTVDkkKANLTMV 35 KPKPNVSVAKDGSG--DFKTISEALAAMPAKYe...GRYVIFVKQGVYDET.VTVTkkMANITMY 36 PVKANAVVAQDGTG--QFKTITDALNAVPKGNk...VPFIIHIKEGIYKEK.VTVTkkMPHVTFI 37 GIKANVVVAKDGSG--KCKTIAQALAMVPMKNt...KKFVIHIKEGVYKEK.VEVTkkMLHVMFV 38 DVKPDIVVAQDGSG--QYKTINEALQFVPKKRn...TTFVVHIKAGLYKEY.VQVNktMSHLVFI 39 QIQADIIVSKDGNG--TCKTISEAIKKAPQNSt...RRIIIYVKAGRYEENnLKVGrkKINLMFV 40 AMRVDVVVAQDGSG--RWRTVSEAVARAPSHSr...RRYVIYVKRGVYEEN.VEVRkkKTNIVIV 41 --HPNTVVAIDGKG--KYRTINEAINEAPNHSt...KRYVIYVKKGVYKEN.IDLKkkKTNIMLV 42 --KVDVVVAQDGSG--DYKTIQEAVNGAGERLkgs.PRYVIHVKQGVYEEY.VNVGikSNNIMIT 43 HVTANVVVAKDGTG--KFKTVNEAVAAAPENSn...TRYVIYVKKGVYKET.IDIGkkKKNLMLV 44 --------------------------------....---------------.----..------- 45 ------TVAADGSG--TFKTVAAAVAAAPENSn...KRYVIHIKAGVYREN.VEVAkkKKNXMFM 46 --------------------------------....---------------.----..------- 47 TIKADATVADDGSG--DFDNGSAAVAAAPEKSn...KRFVIHIKAGVYREN.VEVTkkKTNIMFL 48 TIKADATVADDGSG--DFTTVAAAVAAAPEKSn...KRFVIHIKAGVYREN.VEVTkkKTNIMFL 49 ------TVAADGSG--TFKTVAAAVAAAPENSn...KRYVIHIKAGVYREN.VEVAkkKKNIMFM 50 GVKRDATVAADGSG--TFKTVAAAVAAAPENSn...KRYVIHIKAGVYREN.VEVAkkKKNIMFM 51 SVTPNAVVAADGSG--NFKTVAAAVAAAPQGGt...KRYIIRIKAGVYREN.VEVTkkHKNIMFI 52 SVTPNAVVAADGSG--NFKTVAAAVAAAPQGGt...KRYIIRIKAGVYREN.VEVTkkHKNIMFI 53 SVTPNVVVAADGSG--NFKTVAAAVAAAPQGGt...KRYIIRIKAGVYREN.VEVTkkHKNIMFI 54 --------------------------------....-RYVIRIKAGVYREN.VDVPkkKTNIMFM 55 TVTPDVVVAADGSG--DYKTVSEAVAKAPEKSs...KRYVIRIKAGVYREN.VDVPkkKTNIMFM 56 TVTPDVVVAADGSG--DYKTVSEAVRKAPEKSs...KRYVIRIKAGVYREN.VDVPkkKTNIMFM 57 -TNYNLSVAIDGTG--NFTTINDAVFAAPNMSe...TRFIIYIKGGEYFEN.VELPkkKTMIMFI 58 ETKVNLVVAQNGTG--NYTTIGEAISAAPNSSe...TRFVIYIKCGEYFEN.IEIPreKTMIMFI 59 --------------------------------....---------GAYFEN.VEVIrrKTNLMWV 60 -PKDNAVVAKDGSG--NFKTIKEAIDAAS-GS....GRFVIYVKQGVYSEN.LEIR..KKNVMLR 61 TPRANIVVAQDGSG--NVKTIQEAVAAASRAGg...SRYVIYIKAGTYNEN.IEVK..LKNIMFV 62 TPRANIVVAQDGSG--NVKTIQEAVAAASRAGg...SRYVIYIKAGTYNEN.IEVK..LKNIMFV 63 ---DIVTVIQNGTG--NFTTINAAIAAAPNKTdgsnGYFLIYVTAGLYEEY.VEVPknKRYVMMI 64 ---DIVTVSQDGTG--NFTNITAAVAAAPNNTdgsaGFFLIYVTAGIYEEY.ISIAknKRYMMMI 65 --------------------------------....---------------.----..------- 66 ---DIVTVNQNGTG--NFTTITEAVNSAPNKTdgtaGYFVIYVTSGVYEEN.VVIAknKRYLMMI 67 ----AVIVGPFKSD--NFTTITDAIAAAPNNTrpedGYFVIYAREGVYEEY.IVVPinKKNLMLM 68 -SRADFVVARDGSA--THRTINQALAAVSRMGksrlNRVIIYIKAGVYNEK.IEIDrhMKNIMLV 69 -AKADLVVAKDGSG--HYTSIQQAVNAAAKLPrrn.QRLVIYVKAGVYREN.VVIKksIKNVMVI 70 --VADAVVAADGTG--NFTTISDAVLAAPDYSt...KRYVIHVKRGVYVEN.VEIKkkKWNIMMV 71 --------------------------------....---------------.----..------- 72 -VSVDAIVAQDGTG--NFTNVTDAVLAAPDYSm...RRYVIYIKRGTYKEN.VEIKkkKWNLMMI 73 -RTYDVSVALDGTG--NFTKIMDAIKKAPDYSs...TRFVIYIKKGLYLEN.VEIKkkKWNIVML 74 DIKANVVVAKDGSG--KFKTVAEAVASAPDNGk...ARYVIYVKRGTYKEK.VEIGkkKTNVMLV 75 DIKANVVVAKDGSG--KFKTVAEAVASAPDNGk...ARYVIYVKRGTYKEK.VEIGkkKTNVMLV 76 --KANVVVAQDGSG--KFKTVTEAVASAPDNGk...TRYVIYVKKGTYKEH.VEIGkkKKNIMLV 77 DVKANVVVAQDGSG--KFKTVTEAVASAPDNGk...TRYVIYVKKGTYKEH.VEIGkkKKNIMLV 78 ------VVAKDGSG--KFKTVAEAVASAPDN-....RRYVIYVKKGTYKEN.VEIGkkKKNVMLV 79 --------AKDGSG--KYKTLLEAVASAPDNSk...TRFVIYVKKGTYKEN.VEIGkkKKNIMLV 80 --------------------------------....--------------N.VEIGkkKKNVMLV 81 AITANVVVANDGSG--KYKTIKEAVASVPDNSn...SRYVIYVKKGIYKEN.VEIGkkKKNVMLV 82 AITANVIVAKDGSG--KYKTVKEAVASVPDNSn...SRYVIYVKKGIYKEN.VEIGkkKKNVMLV 83 DIIANRVVAQDGTG--DYQTLAEAVAAAPDKNk...TRYVIYVKMGIYKEN.VVVTkkKMNLMIV 84 --------------------------------....--------------N.VEVTkkKMNLMIV 85 ------VVAKDGTG--DYQTLAEAVAAAPDRSk...TRYVIYVKMGIYKEN.VEVTsrKMNLMIV 86 DIKANAVVAQDGTG--DYQTLAEAVAAAPDKSk...TRYVIYVKMGIYKEN.VEVTsrKMNLMIV 87 DIIANAVVAQDGTG--DYQTLAEAVAAAPDKSk...TRYVIYVKRGTYKEN.VEVSsnKMNLMIV 88 DIIANAVVAQDGTG--DYQTLAEAVAAAPDKSk...TRYVIYVKRGTYKEN.VEVAsnKMNLMIV 89 DIIANRVVAQDGTG--KYRTLAEAVAAAPNRSk...KRYVIYVKRGIYKEN.VEVSsnKMNLMIV 90 -IGANAVVAKDGTG--KYRTLAEAVAAAPDKSk...TRYVIYVKRGIYKEN.VEVSsrKMKLMIV 91 -IGANAVVAKDGTG--KYRTLAEAVAAAPDKSk...TRYVIYVKRGTYKEN.VEVSsrKMNLMII 92 -IGANAVVAKDGTG--KYRTLAEAVAAAPDKSk...TRYVIYVKRGTYKEN.VEVSsrKMNLMII 93 -IGANAVVAKDGTG--KYRTLAEAVAAAPDKSk...TRYVIYVKRGTYKEN.VEVSsrKMNLMII 94 -TNRSIIVDIEGKG--DYTSVQKAIDAVPVGNs...NWIIVHVRKGIYKER.VHIPenKPFIFMR 95 -VVNTIVVDQAGSG--KFRTVQAAIDSVGELNs...LWIKIKVKRGVYN--.----..------- 96 QIAYTITVDLNGGG--NFTTVQSAIDSISPPNh...NWIRVFTQNGIYR--.----..------- 97 -IAKTIIVNPNDAR--YFKTVQSAIDSIPLQNq...DWIRILISNGIYSEK.VTIPrgKGYIYMQ 98 -TTSYLCVDKNGCC--NFTTVQSAVDAVGNFSq...RRNVIWINSGI--EK.VVIPktKPNITLQ 99 -TSLVLTVDLHGCG--NFSNVQSAIDVVPDLSs...SKTLIIVNSGSYREK.VTVNenKTNLVIQ 100 -FTMVLKVSLNGCG--RFKRVQDAIDASIGSSq...SKTLILIDFGIYRER.FIVHenKNNLVVQ 101 -TAILIRVDQSGKG--DFSKIQEAIESIPPNLnns.QLYFIWVKPGIYREK.VVIPaeKPYITLS 102 -SRRVIIVNQNGGG--DFKTINAAIKSIPLANk...NRVIIKLAPGIYHEK.VTVDvgRPYVTLL 103 -ARQIITVNQKGGA--NFKTLNEAIKSIPTGNk...NRVIIKLAPGVYNEK.VTIDiaRPFITLL 104 --------------GGEFKTLTDAIKSVPAGNt...KRVIIKMAPGEYKEK.VTIDrnKPFITLM 105 ---RIINVNPKGGE---FKTLTDAIKSVPAGNt...KRVIIKMAHGEYREK.VTIDrnKPFITLM 106 -TTYNAVVSKSSSDGKTFKTIADAIASAPAGS....TPFVILIKNGVYNER.LTIT..RNNLLLK 107 ATTYNAVVSKSSSDGKTFKTIADAIASAPAGS....TPFVILIKNGVYNER.LTIT..RNNLHLK 108 -TTYNAVVSKSSSDGKTFKTIADAIASAPAGS....TPFVILIKNGVYNER.LTIT..RNNLHLK 109 GFRANYAVAADGSA--QYKTVQAAIDAAVADGgv..ARKYISVKAGTYNEL.VCVPesAPPITLY 110 --------------------------------....---------------.----..------- 111 --------------------------------....---------------.----..------- 112 -TAAYVVGPRAGVAGATHTSIQQAVNAALRQHpgq.TRVYIKLLPGTYTGT.VYVPegAPPLTLF 113 PAQPDFVVGPAGTQGVTHTTIQAAVDAAIIKRtn..KRQYIAVMPGEYQGT.VYVPaaPGGITLY 114 PAQPDFVVGPAGTQGVTHTTIQAAVDAAIIKRtn..KRQYIAVMPGEYQGT.VYVPaaPGGITLY 115 ---PAGCLTVGGSG--KYKTVQSAVNALDKSTs...KAQCIFIAKGTYTEQ.VYIQqlNSPLTIY 116 -----GCLSVGSSG--TYKTVSAAVAKLSTSSt...TAQCIFIYKGTYKEQ.VYVPalKSALTIY 117 --SGAIVVAKSGGD---YTTIGDAIDALSTSTt...DTQTIFIEEGTYDEQ.VYLPamTGKVIIY 118 --SGAIVVAKSGGD---YDTISAAVDALSTTSt...ETQTIFIEEGSYDEQ.VYIPalSGKLIVY 119 --AGAIVVAKSGGD---YDTLSAAVNALSTTEt...ATQTIFIEEGTYDEQ.VYIPslAGKLIIY 60 70 80 90 100 | | | | | 1 ..GRPWKEYSRTVVMES-------Y........LG..GLINPAGW........AEWDGDFALKTL 2 ..GDGARKTVISYNRSV------AL........SR..GTTTSLSA........TVESEGFMAKWM 3 ..GDGARKTVISYNRSVAL----SR........GT..TTSLSATV........QVESEGFMAKWM 4 ..GDGARKTVISYNRSVKL----SP........GT..TTSLSGTV........QVESEGFMAKWI 5 ..GDGARKTVISYNRSVKL----SP........GT..TTSLSGTV........QVESEGFMAKWI 6 ..GDGATQTIITFDRSVKL----SP........GT..TTSLSGTV........QVESEGFMAKWI 7 ..GDGATQTIITFDRSVGL----SP........GT..TTSLSGTV........QVESEGFMAKWI 8 ..GDGATQTIITFDRSVGL----SP........GT..TTSLSGTV........QVESEGFMAKWI 9 ..GDGMGKTVITGSLNAG-----MP........GI..TTYNTATV........GVVGDGFMARDL 10 ..GDGMGKTVITGSISTG-----IT........RI..TTYNTATV........GILGDGFMASGL 11 ..GDGERKTIITSGRSV------QH........GY..TTYNSATG........GFGGQRFVAKDM 12 ..GDGPTKTKFTGSLNY------AD........GI..NTYKTATF........GVNGANFMAKDI 13 ..GDGPTKTKFTGSLNY------AD........GI..NTYNTATF........GVNGANFMAKDI 14 ..GDGPAKTKFTGSLNY------AD........GL..LPYNTATL........GVNGENFMAKDI 15 ..GDGPKQSRVTGRKSF------AD........GI..TTMKTATF........SVEASGFICKNM 16 ..GEGPTKTKITGNKSV------KD........GP..STFHTTTV........GVNGANFVAKNI 17 ..GEGPTKTKITGNKSV------KD........GP..STFHTTTV........GVNGANFVAKNI 18 ..GDGKYSTIIVGDDSV------AG........GS..TMPGSATI........TMTGDGFIARDI 19 ..GDGKGKTVIVGSRSN------RG........GW..NTYQSATV........AAMGDGFIARDI 20 ..GDGKGKTVIVGSRSN------RG........GW..TTYKTATV........AAMGEGFIARDM 21 ..GDGKGKTIISGSKNF------VD........GT..PTYETATF........AIQGKGFIMKDI 22 ..GDGKDKTFVLGSRNF------MD........GT..PTFETATF........AVKGKGFIAKDI 23 ..GDGKDKTFVVGSRNF------MD........GT..PTFETATF........AVKGKGFIAKDI 24 ..GDGESKSIVSGRLNV------ID........GT..PTFKTATF........AVFGKGFMARDM 25 ..GDGSDVTFITGNRSV------GD........GW..TTFRSATL........AVSGEGFLARDI 26 ..GDGRDLTVLSGDLNG------VD........GI..KTFDSATL........AVDESGFMAQDL 27 ..-----------------------........--..--------........-IDGNWFMAQDL 28 ..-----------------------........--..--------........------------ 29 ..-----------------------........--..--------........-------MAQDI 30 ..GDGQDSTIITGNLSA------SN........VR..RTFYTATFdns11mfeASNGKGFIGVDM 31 ..GDGQDLTIITSNLSA------SN........VR..RTFNTATVgkn27ifeASNGNGFIGVDM 32 ..ADGQDSTIITFNLSS------SN........SK..RTFNTATF........-----GKNLVDM 33 ..GDGSQKTIVTGNKSH------AK........KI..RTFLTATF........VAQGEGFMAQSM 34 ..GDGSQKTIVTGNKSH------AK........KI..RTFLTATF........VAQGEGFMAQSM 35 ..GDGSQKTIVTGNKNF------AD........GV..QTFRTATF........AVLGDGFLCKFM 36 ..GDGPNKTLITGSLNFG-----IG........KV..KTFLTATI........TIEGDHFTAKNI 37 ..GDGPTKTVITGDIAFL-----PD........QV..GTYRTASV........AVNGDYFMAKDI 38 ..GDGPDKTIISGNKNY------KD........GI..TTYRTATV........AIVGNYFIAKNI 39 ..GDGKGKTVISGGKSI------FD........NI..TTFHTASF........AATGAGFIARDI 40 ..GEGMGETVITGSRSM------AA........GW..TTFRSATF........AVSGAGFIARDM 41 ..GDGIGQTIITGDRNF------MQ........GL..TTFRTATV........AVSGRGFIAKDI 42 ..GDGIGKTIITGDKSK------GR........GF..STYKSATF........VAEGDGFVGRDI 43 ..GDGKDATIITGSLNV------ID........GS..TTFRSATV........------------ 44 ..-----------------------........--..--------........------------ 45 ..GDGRTRTIITGSRNV------VD........GS..TTFHSATV........AAVREKFLTRDI 46 ..-----------------------........--..--------........------------ 47 ..GDGRGKTIITGSRNV------VD........GS..TTFHSATV........AAVGERFLARDI 48 ..GDGRGKTIITGSRNV------VD........GS..TTFHSATV........AAVGERFLARDI 49 ..GDGRTRTIITGSRNV------VD........GS..TTFHSATV........AAV--------- 50 ..GDGRTRTIITGSRNV------VD........GS..TTFHSATV........AAVGERFLARDI 51 ..GDGRTRTIITGSRNV------VD........GS..TTFKSATA........AVVGEGFLARDI 52 ..GDGRTRTIITGSRNV------VD........GS..TTFKSATV........AVVGEGFLARDI 53 ..GDGRTRTIITGSRNV------VD........GS..TTFKSATV........------------ 54 ..GDGRSNTIITGSRNV------KD........GS..TTFNSATV........AAVGEKFLARDI 55 ..GDGRSNTIITASRNV------QD........GS..TTFHSATV........AAVGEKFLARDI 56 ..GDGKSNTIITASRNV------QD........GS..TTFHSATV........VRVAGKVLARDI 57 ..GDGIGKTVIKANRSR------ID........GW..STFQTPTV........GVKGKGYIAKDI 58 ..GDGIGRTVIKANRSY------AD........GW..TAFHSATV........GVRGSGFIAKDL 59 ..GDGIGKTVVKASRNV------VD........GW..TTFQSATV........AVVGDGFIAKGV 60 ..GDGIGKTIITGSKSV------GG........GT..TTFNSATV........AAVGDGFIARGI 61 ..GDGIGKTIITGSKSV------GG........GA..TTFKSATV........AVVGDNFIARDI 62 ..GDGIGKTIITGSKSV------GG........GA..TTFKSATV........AVVGDNFIARDI 63 ..GDGINQTVITGNRSV------VD........GW..TTFNSATF........ILSGPNFIGVNI 64 ..GDGINQTVVTGNRSV------VD........GW..TTFNSATF........AVTAPNFVAVNI 65 ..-----------------------........--..--------........------------ 66 ..GDGINRTVVTGNRNV------VD........GW..TTFNSATF........AVTSPNFVAVNM 67 ..GDGINKTIITGNHNV------VD........GW..TTYNCSSF........AVVGERFMAVDV 68 ..GDGMDRTIVTNNRNV------PD........GS..TTYGSATF........GVSGDGFWARDI 69 ..GDGIDSTIVTGNRNV------QD........GT..TTFRSATF........AVSGNGFIAQGI 70 ..GDGIDATVITGNRSF------ID........GW..TTFRSATF........AVSGRGFIARDI 71 ..-----------------------........--..--------........------------ 72 ..GDGMDATIISGNRSF------VD........GW..TTFRSATF........AVSGRGFIARDI 73 ..GDGIDVTVISGNRSF------ID........GW..TTFRSATF........AVSGRGFLARDI 74 ..GDGMDATIITGNLNF------ID........GT..TTFNSATV........AAVGDGFIAQDI 75 ..GDGMDATIITGNLNF------ID........GT..TTFNSATV........AAVGDGFIAQDI 76 ..GDGMDATIITGSLNF------ID........GT..TTFNSATV........AAVGDGFIGQDI 77 ..GDGMDATIITGSLNF------ID........GT..TTFNSATV........AAVGDGFIGQDI 78 ..GDGKDLTVITGSLNY------ID........GT..GTFQTATV........AAVGDGFIGQDI 79 ..GDGMDATIITGNLNV------ID........GS..TTFKSATV........AAVGDGFIAQDL 80 ..GDGMDATIITGNLNV------VD........GA..TTFNSATV........AAVGDGFIAQDV 81 ..GDGMDATIITGNLNV------VD........GA..TTFNSATV........AAVGDGFIAQDV 82 ..GDGMDATIITGNLNV------VD........GA..TTFNSATV........AAVGDGFIAQDV 83 ..GDGMNATIITGSLNV------V-........DG..STFPSNTL........AAVGQGFILQDI 84 ..GDGMNSTVITGSLNV------VD........GS..TTFRSATL........AAVGQGFILQDI 85 ..GDGMNATIITGSLNF------VD........GT..TTFRSATL........AAVGQGFILQDI 86 ..GDGMNATIITGSLNY------VD........GT..TTFRSATL........AAVGQGFILQDI 87 ..GDGMYATTITGSLNV------VD........GS..TTFRSATL........AAVGQGFILQDI 88 ..GDGMYATTITGSLNV------VD........GS..TTFRSATL........AAVGQGFILQDI 89 ..GDGMYATTITGSLNV------VD........GS..TTFRSATL........AAVGQGFILQDI 90 ..GDGMHATIITGNLNV------VD........GS..TTFHSATL........AAVGKGFILQDI 91 ..GDGMYATIITGSLNV------VD........GS..TTFHSATL........AAVGKGFILQDI 92 ..GDGMYATIITGSLNV------VD........GS..TTFHSATL........AAVGKGFILQDI 93 ..GDGMYATIITGSLNV------VD........GS..TTFHSATL........AAVGKGFILQDI 94 ..GNGKGKTVIESS---------QS........SV..DNVASATF........KVEANHFVAFGI 95 ..---------TYNRLT--------........--..--------........----------SL 96 ..-----------------------........--..--------........------------ 97 ..GGGIEKTIIAY----------GD........HQ..LTNTSATF........TSYPSNIIITGI 98 ..GQGFDITAIAWNDTA------YS........AN..GTFYCATV........QVFGSQFVAKNI 99 ..GRGYQNTSIEWNDTA------KS........AG..NTADSFSF........VVFAANFTAYNI 100 ..GMGYSRTSIEWNNTT------AS........SN..GTFSSFSV........AVFGEKFTAYNI 101 ..GTQASNTFLIW----------SD........GE..DILESPTL........TIFASDFVCRFL 102 ..GKPGAETNLTYAGTA-------A........KY..GTVESATL........IVWATNFLAANL 103 ..GQPGAETVLTYHGTA-------A........QY..GTVESATL........IVWAEYFQAAHL 104 ..GQPNAMPVITYDGTA-------A........KY..GTVDSASL........IILSDYFMAVNI 105 ..GQPNAMPVITYDGTA-------A........KY..GTVDSASL........IILSDYFMAVNI 106 ..GESRNGAVIAAATAAGTLKSDGS........KW..GTAGSSTI........TISAKDFSAQSL 107 ..GESRNGAVIAAATAAGTLKSDGS........KW..GTAGSSTI........TISAKDFSAQSL 108 ..GESRNGAVIAAATAAGTLKSDGS........KW..GTAGSSTI........TISAKDFSAQSL 109 slDANANNTVIVYNNANPTPASGAKtnp11snaTV..GTVRSATA........MVRASNFNARNL 110 ..--------------------TAC........GG..QTPNSARF........QPVFPGTVSRPV 111 ..-----------------------........--..--------........------------ 112 ..GAGDRPEQVVVSLALDSMMSPADyra30agaTI..NTTCSAVM........WSQSNDFQLKNL 113 ..GTGEKPIDVKIGLSLDGGMSPADwrh30rsdSI..GVLCSAVF........WSQNNGLQLQNL 114 ..GTGEKPIDVKIGLSLDGGMSPADwrh30rsdSI..GVLCSAVF........WSQNNGLQLQNL 115 ..GETKDTRSYSGNTVTITQRKSQN........DTp.SNDETATL........RAHTPNLKVYNI 116 ..GETTDTSGFASNTVTITQGKSQD........DVs.GNDLTATL........RAWTPNLKVYNI 117 ..GQTENTDSYADNLVTITHAISYE........DAgeSDDLTATF........RNKAVGSQVYNL 118 ..GQTEDTTTYTSNLVNITHAIALA........DVd.NDDETATL........RNYAEGSAIYNL 119 ..GQTEDDTTYTGNLVNITHNIKLA........DVa.NDDETATV........RNHSPNSSIYNL 110 120 130 140 150 160 | | | | | | 1 YYGEFMN----------------------GKV--GADMSVINRCRIDAYQDTLYA........HS 2 GFKNTAG--------------PMGHQAAAIRV--NGDRAVIFNCRFDGYQDTLYV........NN 3 GFKNTAG--------------PMGHQAAAIRV--NGDRAVIFNCRFDGYQDTLYV........NN 4 GFKNTAG--------------PMGHQAVAIRV--NGDRAVIFNCRFDGYQDTLYV........NN 5 GFKNTAG--------------PMGHQAVAIRV--NGDRAVIFNCRFDGYQDTLYV........NN 6 GFKNTAG--------------PLGHQAVALRV--NGDRAVIFNCRFDGYQDTLYV........NN 7 GFQNTAG--------------PLGHQAVAFRV--NGDRAVIFNCRFDGYQDTLYV........NN 8 GFQNTAG--------------PLGNQAVAFRV--NGDRAVIFNCRFDGYQDTLYV........NN 9 TFQNTAG--------------PDAHQAVAFRS--DSDFSLIENCEFLGNQDTLYA........HG 10 TIENTAG--------------PDAHQAVAFRS--DSDFSYIENCEFLGNQDTIYV........HS 11 TFINTAG--------------PLRGQAVAVRS--SSDLSVFYRVGIHGFQDTLYI........HS 12 GFENTAG--------------TSKFQAVALRV--TADQAIFHNCQMDGFQDTLFV........ES 13 GFENTAG--------------TGKHQAVALRV--TADQAIFYNCQMDGFQDTLYV........QS 14 SIENTAG--------------PEKHQAVALRV--TADKAIFYNCQIDGYQATLFA........ES 15 GFHNTAG--------------AERHQAVALRV--QGDLAAFYNCRFDAFQDTLYV........QP 16 GFENTAG--------------PEKEQAVALRV--SADKAIIYNCQIDGYQDTLYV........HT 17 GFENTAG--------------PEKEQAVALRV--SADKAIIYNCQIDGYQDTLYV........HT 18 GFQNTAG--------------PQGEQALALNI--ASDHSVLYRCSIAGYQDTLYA........HA 19 TFVNSAG--------------PNSEQAVALRV--GSDRSVVYRCSIDGYQDSLYT........LS 20 TFVNNAG--------------PKSEQAVALRV--GADKSVVHRCSVEGYQDSLYT........HS 21 GIINTAG--------------AAKHQAVAFRS--GSDFSVYYQCSFDGFQDTLYP........HS 22 GFVNNAG--------------ASKHQAVALRS--GSDRSVFFRCSFDGFQDTLYA........HS 23 GFVNNAG--------------ASKHQAVALRS--GSDRSVFFRCSFDGFQDTLYA........HS 24 GFINTAG--------------PSKHQAVALMV--SADLTAFYRCTMNAYQDTLYV........HA 25 MITNTAG--------------PEKHQAVALRV--NADFVALYRCVIDGYQDTLYT........HS 26 CIRNTAG--------------PEKRQAVALRI--STDMTIIYRCRIDAYQDTLYA........YS 27 WIQNTAG--------------PAKGQAVALRV--SGDAVVIYRCRIDAYQDTLYA........HS 28 -------------------------------------------------------........-- 29 WFQNTAG--------------PAKHQAVALRV--SADQTVINRCRIDAYQDTLYT........HT 30 CFRNTVG--------------PAKGPAVALRV--SGDMSVIYRCRVEGYQDALYP........HI 31 CFRNTAG--------------PAKGPAVALRV--SGDMSVIYRCRVEGYQDALYP........HS 32 CFRNTTW--------------PVKGPVVTLRV--NGDMSIIYRCRVEEYQDALYP........HK 33 GFRNTAG--------------PEGHQAVAIRV--QSDRSVFLNCRFEGYQDTLYA........YT 34 GFRNTAG--------------PEGHQAVAIRV--QSDRSIFLNCRFEGYQDTLYA........YT 35 GFRNTAG--------------PEKHQAVAIRV--QADRAIFLNCRFEGYQDTLYA........QT 36 GIENTAG--------------PEGGQAVALRV--SADYAVFHSCQIDGHQDTLYV........HS 37 GFENTAG--------------AARHQAVALRV--SADFAVFFNCHMNGYQDTLYV........HT 38 GFENTAG--------------AIKHQAVAVRV--QSDESIFFNCRFDGYQDTLYT........HS 39 TFENWAG--------------PAKHQAVALRI--GADHAVIYRCNIIGYQDTLYV........HS 40 TIRNTAG--------------PAAHQAVALRV--DSDRSAFFRIAVEGHQDTLYA........HS 41 TFRNTAG--------------PQNRQAVALRV--DSDQSAFYRCSVEGYQDTLYA........HS 42 TIRNTAG--------------PENHQAVALRS--NSDMSVFYRCSIEGYQDTLYV........HS 43 -------------------------------------------------------........-- 44 -------------------------------------------------------........-- 45 TFXNT--------------------------------------------------........-- 46 --------------------------------------------------DTLYA........HS 47 TFQNTAG--------------PSKHQAVALRV--GSDFSAFYQCDMFAYQDTLYV........HS 48 TFQNTAG--------------PSKHQAVALRV--GSDFSAFYQCDMFAYQDTLYV........HS 49 -------------------------------------------------------........-- 50 TFQNTAG--------------PSKHQAVALRV--GSDFSAFYNCDMLAYQDTLYV........HS 51 TFQNTAG--------------PSKHQAVALRV--GADLSAFYNCDMLAYQDTLYV........HS 52 TFQNTAG--------------PSKHQAVALRV--GADLSAFYNCDMLAYQDTLYV........HS 53 -------------------------------------------------------........-- 54 TFQNTAG--------------AAKHQAVALRV--GSDLSAFYRRDILAYQDSLYV........HS 55 TFQNTAG--------------ASKHQAVALRV--GSDLSAFYKCDILAYQDTLYV........HS 56 TFQNTAG--------------ASKHQAVALCV--GSDLSAFYRCDMLAYQDTLYV........HS 57 SFVNSAG--------------PAKAQAVAFRS--GSDHSAFYRCEFDGYQDTLYV........HS 58 SFVNYAG--------------PEKHQAVALRS--SSDLSAYYRCSFESYQDTIYV........HS 59 TFENSAG--------------PSKHQAVALRN--GADFSAFYQCSFVAYQDTLYV........HS 60 TFRNTAG--------------ASNEQAVALRS--GSDLSVFYQCSFEAYQDTLYV........HS 61 TIRNTAG--------------PNNHQAVALRS--GSDLSVFYRCSFEGYQDTLYV........HS 62 TIRNTAG--------------PNNHQAVALRS--GSDLSVFYRCSFEGYQDTLYV........HS 63 TIRNTAG--------------PTKGQAVALRS--GGDLSVFYSCSFEAYQDTLYT........HS 64 TFRNTAG--------------PEKHQAVALRS--GADFSIFYSCSFEAYQDTLYT........HS 65 -------------------------------------------------------........-- 66 TFRNTAG--------------PEKHQAVAMRS--SADLSIFYSCSFEAYQDTLYT........HS 67 TFRNTAG--------------PEKHQAVALRN--NAEGSSFYRCSFEGYQDTLYV........HS 68 TFENTAG--------------PHKHQAVALRV--SSDLSLFYRCSFKGYQDTLFT........HS 69 TFENTAG--------------PEKHQAVALRS--SSDFSVFYACSFKGYQDTLYL........HS 70 TFQNTAG--------------PEKHQAVAIRS--DTDLGVFYRCAMRGYQDTLYA........HS 71 -----------------------------------------------GFQDTLYP........HT 72 TFENTAG--------------PEKHQAVALRS--DSDLSVFYRCNIRGYQDTLYT........HT 73 TFQNTAG--------------PEKHQAVALRS--DSDLSVFFRCAMRGYQDTLYT........HT 74 GFQNTAG--------------PEKHQAVALRV--GADQSVINRCKIDAFQDTLYA........HS 75 GFQNTAG--------------PEKHQAVALRV--GADQSVINRCKIDAFQDTLYA........HS 76 -FQNTAG--------------AAKHQAVALRV--GADQSVINRCRIDAFQDTLYA........HS 77 WFQNTAG--------------AAKHQAVALRV--GADQSVINRCRIDAFQDTLYA........HS 78 WFQNTAG--------------PQKHQAVALRV--GADQSVINRCRVDAYQDTLYA........HT 79 QFQNTAG--------------PQKHQAVALRV--GADQSVINRCKIDAFQDTLYT........HT 80 QFQNTAG--------------AAKHQAVALRV--GAGQSVINRCKIDAFQDTLYT........HS 81 QFQNTAG--------------AAKHQAVALRV--GADQSVINRCKIDAFQDTLYT........HS 82 QFQNTAG--------------AAKHQAVALRV--GADQSVINRCKIDAFQDTLYT........HS 83 CIQNTAG--------------PEKDQAVALRV--GADMSVINRCRIDAYQDTLYA........HS 84 CIQNTAG--------------PEKHQAVALRV--GADMSVINRCRIDAYQDTLYA........HS 85 CIQNTAG--------------PEKHQAVALRI--GGDMSVINRCRIDAYQDTLYA........HS 86 CIQNTAG--------------PEKHQAVALRV--GGDMSVINRCPIDAYQDTLYA........HS 87 CIQNTAG--------------PAKDQAVALRV--GADMSVINRCRIDAYQDTLYA........HS 88 CIQNTAG--------------PAKDQAVALRV--GADMSVINRCRIDAYQDTLYA........HS 89 CIQNTAG--------------PAKDQAVALRV--GADMSVINRCRIDAYQDTLYA........HS 90 CIQNTAG--------------PAKHQAVALRV--GADKSVINRCRIDAYQDTLYA........HS 91 CIQNTAG--------------PAKHQAVALRV--GADKSVINRCRIDAYQDTLYA........HS 92 CIQNTAG--------------PAKHQAVALRV--GADKSVINRCRIDAYQDTLYA........HS 93 CIQNTAG--------------PAKHQAVALRV--GADKSVINRCRIDAYQDTLYA........HS 94 SIRNDAPVGMAF---------TSENQSVAAFV--AADKVAFYHCAFYSLHNTLFD........NK 95 TKANGMS--------------WDIKPAVAISV--YGDKSAFYNCDFLGLQDTVWD........NL 96 -------------------------------M--LGDRYVVTDSSFVGLQDTLFD........GK 97 TFKNKYNI---------ASSSSPTKPAVAAMM--LGDKYAIIDSSFDGFQDTLYD........DY 98 SFMNVAPIPKPG---------DVGAQAVAIRI--AGDESAFVGCGFFGAQDTLHD........DR 99 SFKNNAPEPDPG---------EADAQAVALRI--EGDQAAFYGCGFYGAQDTLLD........DK 100 SFKNTAPAPNPG---------AVDAQAVALKV--VGDKAAFYGCGFYGNQDTLLD........QE 101 TIQNKFG---------------TAGRAVALRV--AADKAAFYGCVITSYQDTLLD........DN 102 NIINTSPMPKPG----------TQGQALAMRI--NGDKAAFYNCRFYGFQDTLCD........DR 103 TIKNTAPMPKPG----------SQGQALAMRI--NADKAAFYSCRFHGFQDTLCD........DK 104 VVKNTAPAPDGK---------TKGAQALSMRI--SGNFAAFYNCKFYGFQDTICD........DT 105 VVKNTAPAPDGK---------TKGAQALSMRI--SGNFAAFYNCKFYGFQDTICD........DT 106 TIRNDFDFPANQAKSDSDSSKIKDTQAVALYVTKSGDRAYFKDVSLVGYQDTLYV........SG 107 TIRNDFDFPANQAKSDSDSSKIKDTQAVALYVTKSGDRAYFKDVSLVGYQDTLYV........SG 108 TIRNDFDFPANQAKSDSDSSKIKDTQAVALYVTKSGDRAYFKDVSLVGYQDTLYV........SG 109 TFKNSYV---------EGTFADNNQSAVALAV--RGDKAILENVSVIGNQDTLYLgatnnt..MV 110 LSAQEAG--------------RFTHQAVALRT--DGESGATGKCPPAQPSDTFFVnts12vtdHY 111 -----------------------------------------------GRQDTFFVnts12vtdRY 112 TVVNALL----------DTVDSGTHQAVALRT--DGESGATGKCPPAQPSDTFFVnts12vtdHY 113 TIENTLG----------DSVDAGNHPAVALRT--DGDQVQINNVNILGRQNTFFVtns12etnRQ 114 TIENTLG----------DSVDAGNHPAVALRT--DGDQVQINNVNILGRQNTFFVtns12etnRQ 115 NLVNTRG---------------QGSQALAVSA--WADKQGYYGCSFKGYQDTVLA........QL 116 NIVNTRG---------------EGSQALALSA--NADKQGYYGCQFKGYQDTILA........QT 117 NIANTCG--------------QACHQALALSA--WADQQGYYGCNFTGYQDTLLA........QT 118 NIANTCG--------------QACHQALAVSA--YASEQGYYACQFTGYQDTLLA........ET 119 NIINTCG--------------QVCHQALAVSP--YGNGQGYYGCQFTGYQDTLLA........QS 170 180 190 200 210 220 | | | | | | 1 QRQFYRDDYVTGTVDFIFGG.AAVVKNKCQLVARKP----.GKYQQNMVTAQGRt.DPNQATGTS 2 GRQFYRNCVVSGTVDFIFGK.SATVIQNTLIVVRKG----.SKGQYNTVTADGNelGLGMKIGIV 3 GRQFYRNCVVSGTVDFIFGK.SATVIQNTLIVVRKG----.SKGQYNTVTADGNelGLGMKIGIV 4 GRQFYRNIVVSGTVDFIFGK.SATVIQNSLIVVRKG----.NKGQFNTVTADGNekGLAMKIGIV 5 GRQFYRNIVVSGTVDFIFGK.SATVIQNSLIVVRKG----.NKGQFNTVTADGNekGLAMKIGIV 6 GRQFYRNIVVSGTVDFIFGK.SATVIQNSLILVRKG----.SPGQSNYVTADGNekGAAMKIGIV 7 GRQFYRNIVVSGTVDFIFGK.SATVIQNSLILCRKG----.SPGQTNHVTADGNekGKAVKIGIV 8 GRQFYRNIVVSGTVDFINGK.SATVIQNSLILCRKG----.SPGQTNHVTADGKqkGKAVKIGIV 9 LRQFYKNCRIQGNVDFIFGN.SAAVFQDCEILIAPRQINP.EKGEKNAVTAQGRi.DPSQSTGFV 10 LRQLFKSCRIEGNVDFIFGN.AAAIFQDCTILVRPRQVKP.EKGETNAIAAHGRt.DPAQTTGFA 11 QRQFFRECYISGTIDFIFGN.AAVVFQNCMILVRRP----.LHGQANIITAQGRg.DPFQNTGIT 12 QRQFYRDCAISGTIDFVFGD.AFGVFQNCKLICRVP----.AKGQKCLVTAGGRd.KQNSASALV 13 QRQFYRDCSISGTIDFVFGE.RFGVFQNCKLVCRLP----.AKGQQCLVTAGGRe.KQNSASALV 14 QRQFYRDCSISGTIDMIYGD.AFAVFQNCKLIVRKP----.LEEQQCFVAADGRt.KSDSSSGFV 15 RRQFFRNCVVSGTIDFIFGN.SAAVFQNCLIITRRP----.MDNQQNSVTAHGPt.DPNMKSGLV 16 YRQFYRDCTITGTVDFIFGN.GEAVLQNCKVIVRKP----.AQNQSCMVTAQGRt.EPIQKGAIV 17 YRQFYRDCTITGTVDFIFGN.GEAVLQNCKVIVRKP----.AQNQSCMVTAQGRt.EPIQKGAIV 18 LRQFYRECDIYGTVDFIFGN.AAAVFQNCYLVLRLP----.RKKGYNVILANGRs.DPGQNTGFS 19 KRQFYRETDITGTVDFIFGN.SAVVFQSCNLVSRKG----.-SSDQNYVTAQGRs.DPNQNTGIS 20 KRQFYRETDITGTVDFIFGN.SAVVFQSCNIAARKP----.LPGQRNFVTAQGRs.NPGQNTGIA 21 NRQFYRDCDVTGTIDFIFGS.AAVVFQGCKIMPRQP----.LSNQFNTITAQGKk.DPNQSSGMS 22 NRQFYRDCDITGTIDFIFGN.AAVVFQSCKIMPRQP----.LPNQFNTITAQGKk.DPNQNTGII 23 NRQFYRDCDITGTIDFIFGN.AAVVFQSCKIMPRQP----.LPNQFNTITAQGKk.DPNQNTGII 24 QRQFYRECTIIGTVDFIFGN.SASVLQSCRILPRRP----.MKGQQNTITAQGRt.DPNMNTGIS 25 FRQFYRECDIYGTIDYIFGN.AAVVFQGCNIVSKLP----.MPGQFTVITAQSRd.TQDEDTGIS 26 GRQFYRDCYITGTVDFIFGR.AAAVFQYCQIEARKP----.GIGQTNILTAQSRe.EDTATSGFS 27 YRQFYRDCFITGTVDFIFGH.ASAIFQNCRIEARKP----.MEGQSNVITAQQS..DKPGTSGFS 28 -----------GTXDFIFGN.SAVVFQNCDIVARNP----.GAGQKNMLTAQGRe.DQNQNTAIS 29 LRQFYRDSYITGTVDFIFGN.SAVVFQNCDIVARNP----.GAGQKNMLTAQGRe.DQNQNTAIS 30 DRQFYRECFITGTVDFICGN.AAAVFQFCQIVARQP----.NMGQSNFITAQSRe.TKDDKSGFS 31 DRQFYRECFITGTVDFICGN.AVAVFQFCQIVARQP----.KMGQSNVITAQSRa.FKDIYSGFT 32 NRQCYREYFLMDTVDFICGN.AAAVFQFCQIV--------.-------------..--------- 33 HRQYYRSCVIIGTVDFIFGD.AAAIFQNCDIFIRKG----.LPGQKNTVTAQGRv.DKFQTTGFV 34 HRQYYRSCVIVGTIDFIFGD.AAAIFQNCNIFIRKG----.LPGQKNTVTAQGRv.DKFQTTGFV 35 HRQFYRSCVITGTVDFIFGD.ATSVFQNCLITVRKP----.LENQQNIVTAQGRi.DGHETTGIV 36 HRQFYRDCTVSGTVDFIFGD.AKCILQNCKIVVRKP----.NKGQTCMVTAQGRs.NVRESTGLV 37 HRQFYRNCRVSGTIDFVFGD.AKAVFQNCEFVIRRP----.MEHQQCIVTAQGRk.DRRETTGIV 38 HRQFFRDCTISGTIDFLFGD.AAAVFQNCTLLVRKP----.LPNQACPITAHGRk.DPRESTGFV 39 NRQFFRECDIYGTVDFIFGN.AAVVLQNCSIYARKP----.MDFQKNTITAQNRk.DPNQNTGIS 40 LRQFYRDCRVSGTVDFIFGN.GIAVIQRTTISTLPP---A.AGQNAGSVTAQGRr.DPNQNTGFA 41 LRQFYRDCEIYGTIDFIFGN.GAAVLQNCKIYTRVP----.LPLQKVTITAQGRk.SPNQNTGFV 42 GRQFFRECDIYGTVDFIFGN.AAAVLQNCRIFARNP----.-PNGVNTITAQSRf.NPNQTTGIV 43 --------------------.-------------------.-------------..--------- 44 -----------GTXDFIFGA.GTVVFQGCSIRPRQP----.LPNQFNTITAEGTq.EANQNTGIS 45 --------------------.-------------------.-------------..--------- 46 NRQFYRECDITGTIDFIFGN.AAVVFQACKIQPRQP----.MSNQFNTITAQGKk.DPNQNTGIS 47 NRQFFVKCHITGTVDFIFGN.AAAVLQDCDINARRP----.NSGQKNMVTAQGRs.DPNQNTGIV 48 NRQFFVKCHITGTVDFIFGN.AAAVLQDCDINARRP----.NSGQKNMVTAQGRs.DPNQNTGIV 49 --------------------.-------------------.-------------..--------- 50 NRQFFVKCLIAGTVDFIFGN.AAVVLQDCDIHARRP----.NSGQKNMVTAQGRt.DPNQNTGIV 51 NRQFFVNCLIAGTVDFIFGN.AAAVLQNCDIHARKP----.NSGQKNMVTAQGRt.DPNQNTGIV 52 NRQFFVNCLIAGTVDFIFGN.AAAVLQNCDIHARKP----.NSGQKNMVTAQGRt.DPNQNTGIV 53 ------------------GQ.TAAVLQNCDIHARKP----.NSGQKNMVTAQGRa.DPNQNTGIV 54 NRQYFVQCLIAGTVDFIFGN.AAAVLQNCDIHARRP----.GSGQKNMVTAQGRt.DPNQNTGVV 55 NRQFFVQCLVAGTVDFIFGN.GAAVLQDCDIHARRP----.GSGQKNMVTAQGRt.DPNQNTGIV 56 NRQFFVQCLVAGTVDFIFGN.GAAVFQDCDIHARRP----.GSGQKNMVTAQGRt.DPNQNTGIV 57 AKQFYRECDIYGTIDFIFGN.AAVVFQNSSLYARKP----.NPGHKIAFTAQSRn.QSDQPTGIS 58 HKQFYRECDIYGTVDFIFGD.ASVVFQNCSLYARRP----.NPNQKIIYTAQGRe.NSREPTGIS 59 LRQFYRECDVYGTVDFIFGN.AAAVLQNCNLYARKP----.NKNQRNLFTAQGRe.DPNQSTGIS 60 NRQFYRDCDVYGTVDFIFGN.AAAVLQNCNIFARRP----.-RSKTNTITAQGRs.DPNQNTGII 61 QRQFYRECDIYGTVDFIFGN.AAVVLQNCNIFARXP----.-PNRTNTLTAQGRt.DPNQNTGII 62 QRQFYRECDIYGTVDFIFGN.AAVVLQNCNIFARKP----.-PNRTNTLTAQGRt.DPNQSTGII 63 LRQFYRECDVYGTVDFIFGN.AAVVLQNCNLYPRQP----.RKGQSNEVTAQGRt.DPNQNTGTA 64 LRQFYRECDVYGTVDFIFGN.AAVVFQNCNLYPRKP----.MPNQFNAITAQGRs.DPNQNTGTS 65 -----------GTXDFIFGN.AAVVFQDCNLYPRQP----.MQNQFNAITAQGRt.DPNQNTGIS 66 LRQFYRECDIYGTVDFIFGN.AAVVFQDCNLYPRQP----.MQNQFNAITAQGRt.DPNQNTGIS 67 LRQFYRECDIYGTVDFIFGN.AAAIFQNCNIYARKP----.MAKQKNAITAHGRl.DPNQNTGIS 68 LRQFYRDCHIYGTIDFIFGD.AAAVFQNCDIFVRRP----.MDHQGNMITAQGRd.DPHTNSEFE 69 SRQFLRNCNIYGTVDFIFGD.ATAILQNCNIYARKP----.MSGQKNTITAQSRk.EPDETTGFV 70 MRQFFRECIITGTVDFIFGD.ATAVFQSCQIKAKQG----.LPNQKNSITAQGRk.DPNEPTGFT 71 NRQFYRECRISGTVDFIFGD.ATVVFQNCQILVKKG----.LPNQKNTITAQGRk.DPAQPTGFS 72 MRQFYRDCKISGTVDFIFGD.ATVVFQNCQILAKKG----.LPNQKNSITAQGRk.DPNEPTGIS 73 MRQFYRECTITGTVDFIFGD.GTVVFQNCQILAKRG----.LPNQKNTITAQGRk.DVNQPSGFS 74 NRQFYRDSFITGTVDFIFGN.AGVVFQKSKLVARKP----.MSNQKNMVTAQGRe.DPNQNTATS 75 NRQFYRDSFITGTVDFIFGN.AGVVFQKSKLVARKP----.MSNQKNMVTAQGRe.DPNQNTATS 76 NRQFYRDSVITGTIDFIFGN.AAVVFQKCNLVARKP----.MSNQKNMVTAQGRe.DPNQNTGTS 77 NRQFYRDSVITGTIDFIFGN.AAVVFQKCNLVARKP----.MSNQKNMVTAQGRe.DPNQNTGTS 78 NRQFYRDSFITGTVDFIFGN.AAVVFQKCYLVARKP----.MSNQKNMVTAQGRe.DPNQSTGTS 79 LRQFYRDCYITGTVDFIFGN.AAVVFQNSKLAARKP----.MSGQKNMVTAQGRe.DPNQVTGTS 80 LRQFYRDCYITGTVDFIFGN.AAVVFQNSKIAARKP----.GSGQKNMVTAQGRe.DPNQNTGTS 81 LRQFYRDCYITGTVDFIFGN.AAVVFQNSKIAARKP----.GSGQKNMVTAQGRe.DPNQNTGTS 82 LRQFYRDCYITGTVDFIFGN.AAVVFQNSKIAARKP----.GSGQKNMVTAQGRe.DPNQNTGTS 83 QRQFYRDSYVTGTVDFIFGN.AAVVFQKCQIVARKP----.NKRQKNMVTAQGRt.DPNQATGTS 84 LRQFYRDCYVTGTVDFIFGN.AAVVLQKCQLVPRKP----.GKNQKNMVTAQGRt.DPNQATGTS 85 QRQFYRDSYVSGTIDFIFGN.AAVVFQKCQLVARKP----.SKYQKNMVTAQGRt.DPNQATGTS 86 QRQFYRDSYVSGTIDFIFGN.AAVVFQKCQLVARKP----.SKNQKNMVTAQGRt.DPNQATGTS 87 QRQFYRDSYVTGTVDFIFGN.AAVVFQKCQLVARKP----.GKYQQNMVTAQGRt.DPNQATGTS 88 QRQFYRDSYVTGTVDFIFGN.AAVVFQKCQLVARKP----.GKYQQNMVTAQGRt.DPNQATGTS 89 QRQFYRDSYVTGTVDFIFGN.AAVVFQKCQLVARKP----.GKYQQNMVTAQGTt.DPNQATGTS 90 QRQFYRDSYVTGTIDFIFGN.AAVVFQKCKLVARKP----.GKYQQNMVTAQGRt.DPNQATGTS 91 QRQFYRDSYVTGTIDFIFGN.AAVVFQKCQLVARKP----.GKYQQNMVTAQGRt.DPNQATGTS 92 QRQFYRDSYVTGTIDFIFGN.AAVVFQKCQLVARKP----.GKYQQNMVTAQGRt.DPNQATGTS 93 QRQFYQSSYVTGTIDFIFGN.AAVVFQKCQLVARKP----.GKYQQNMVTAQGRt.DPNQATGTS 94 GRHYYHECYIQGSIDFIFGR.ATSIFNNCEIFVISD---K.RVKPYGSITAHHRe.SAEEKTGYV 95 GRHHFKNCYIEGAIDFIFGS.GQSVYE-------------.-------------..--------- 96 GRHYYKRCIISGGIDFIFGY.GQSLFKECTLNMTLG-IYA.PDNPYGTITAHQRp.SPSDEGGFV 97 GRHYYKRCVISGGIDFIFGG.AQSIFEGCTLKLRVG-IYP.PNEVYGTITAQGRd.SPTDKGGFV 98 GRHYFKDCYIQGSIDFIFGN.AKSLYQDCRIISMANQLSPgSKAVNGAVTANGRs.SKDENSGFS 99 GRHFFKECFIQGSIDFIFGN.GRSLYQDCTINSIAK--GN.TSGVTGSITAQGRq.SEDEQSGFS 100 GRHFFKGCFIEGSIDFIFGN.GRSLYEDCTLHSIAK----.-ENTIGCITANGKd.TLKDRTGFV 101 GNHYFKNCYIEGATDFICGS.ASSLYERCHLHSLSP----.---NNGSITAQMRt.SATEKSGFT 102 GNHFFKNCYIEGTYDFIFGR.GASLYLTTQLHA-------.VGDGLRVIAAHNRq.STTEQNGYS 103 GNHFFKDCYIEGTYDFIFGR.GASLYLNTQLHA-------.VGDGLRVITAQGRq.SATEQNGYT 104 GNHFFKDCYVEGTFDFIFGS.GTSMYLGTQLHV-------.VGDGIRVIAAHAGk.SAEEKSGYS 105 GNHFFKDCYVEGTFDFIFGS.GTSMYLGTQLHV-------.VGDGIRVIAAHAGk.SAEEKSGYS 106 GRSFFSDCRISGTVDFIFGD.GTALFNNCDLVSRYRADVK.SGNVSGYLTAPST..NINQKYGLV 107 GRSFFSDCRISGTVDFIFGD.GTALFNNCDLVSRYRADVK.SGNVSGYLTAPST..NINQKYGLV 108 GRSFFSDCRISGTVDFIFGD.GTALFNNCDLVSRYRADVK.SGNVSGYLTAPST..NINQKYGLV 109 IRAYFKNSFIQGDTDFIFGA.GTAVFHGCTIQYTAA--RL.GARATSYVFAPST..APDNPHGFL 110 SRAYIKDSYIEGDVDYVFGR.ATAVFDRVRFHTVSS----.RGSKEAYVFAPDS..IPSVKYGFL 111 SRAYIKDSYIEGDVDYVFGR.ATAVFDRVHFHTVSS----.RGAKDIHVFAPDS..MPWAQYGFL 112 SRAYIKDSYIEGDVDYVFGR.ATAVFDRVRFHTVSS----.RGSKEAYVFAPDS..IPSVKYGFL 113 PRTLVTNSYIEGDVDIVSGR.GAVVFDNTEFRVVNS----.RTQQEAYVFAPAT..LSNIYYGFL 114 PRTLVTNSYIEGDVDIVSGR.GAVVFDNTEFRVVNS----.RTQQEAYVFAPAT..LSNIYYGFL 115 GNQVYAKSYIEGATDFIFGQqARAWFDGCDIGV-------.LGAQVGWITASGRa.ADSNPSYYV 116 GNQVYAKSYIEGATDFIFGQkATAWFDGVDIRV-------.LAASLGYITANGRd.SDSNPSYYV 117 GNQLYINSYIEGAVDFIFGQhARAWFQNVDIRVVEG----.--PTSASITANGRs.SETDTSYYV 118 GYQVYAGTYIEGAVDFIFGQhARAWFHECDIRVLEG----.--PSSASITANGRs.SESDDSYYV 119 GNQVYAHNLIEGAVDFIFGQhARAWFQDCDIRVLKG----.--PSSGYITANGRs.SETDTSYYV 230 240 250 260 270 | | | | | 1 IQFCNIIA.SGDLERPVmivgd..--------GMYATTITGSL--NVVEGSTTFRSATLAAVGQ. 2 LQNCRIVP.DRKLTPERltv....ATYLGRPWKKFST--------------TVIMSTEMGDLIRp 3 LQNCRIVP.DRKLTPERltv....ATYLGRPWKKFST--------------TVIMSTEMGDLIRp 4 LQNCRIVP.DKKLAAERliv....ESYLGRPWKKFST--------------TVIINSEIGDVIRp 5 LQNCRIVP.DKKLAAERliv....ESYLGRPWKKFST--------------TVIINSEIGDVIRp 6 LHNCRIIP.DKELEADKlti....KSYLGRPWKKFAT--------------TVIIGTEIGDLIKp 7 LHNCRIMA.DKELEADRltv....KSYLGRPWKPFAT--------------TAVIGTEIGDLIQp 8 LHNCRIMA.DKELEADRltv....KSYLGRPWKPFAT--------------TAVIGTEIGDLIQp 9 FLNCLING.TEEYMKLFkanpkvhKNFLGRPWKDYSR--------------TVFIGCNLEALITp 10 FLGCLING.TDDYMKLYhskpskhKNYLGRPWKMYSR--------------TVYINCTMESLIAp 11 IHSSRIIA.ASDLKPVIray....KTYLGRPWQAYSR--------------VTIMKTYIDNSISp 12 FLSSHFTG.EPALTSVTpk.....LSYLGRPWKLYSK--------------VVIMDSTIDAMFAp 13 FQSSHFTG.EPALTSVTpk.....VSYLGRPWKQYSK--------------VVIMDSTIDAIFVp 14 FQSCHFTG.EPEVAKIDpk.....IAYLGRPWKSYSK--------------VVIMDSNIDDIFDp 15 IQNCRLVP.DQKLFPDRfki....PSYLGRPWKEFSR--------------LVIMESTIADFVKp 16 LQNCEIKP.DTDYFSLSpps....KTYLGRPWKEYSR--------------TIIMQSYIDKFIEp 17 LQNCEIKP.DTDYFSLSpps....KTYLGRPW--------------------------------. 18 VHNCRIVP.SSEFSPVKhky....ESYLGRPW--------------------------------. 19 IHNCRITG.ST------.......KTYLGRPWKQYSR--------------TVVMQSFIDGSIHp 20 IQNCRITA.ES------.......MTYLGRPWKEYSR--------------TVVMQSFIGGSIHp 21 IQRCTISA.NGNVIA--.......PTYLGRPWKEFST--------------TVIMETVIGAVVRp 22 IQKSTITP.FGNNLTA-.......PTYLGRPW--------------------------------. 23 IQKSTITP.FGNNLTA-.......PTYLGRPWKDFST--------------TVIMQSDIGALLNp 24 IHRCNISP.LGDLTDV-.......MTFLGRPWKNFST--------------TVIMDSYLHGFIDr 25 MQNCSILA.SEDLFNSSnkv....KSYLGRPWREFSR--------------TVVMESYIDEFIDg 26 FQKCNISA.SSDLTPIKgtv....KTFLGRPWRAFSR--------------VVFMESFIDDVIDr 27 IQNCSITA.SSDLVPVKrmv....KTFLGRPWGDFST--------------VVFMESYLDDMIDp 28 IQKCKITA.SSDLAPVKgsv....KTYXGRPWKEY-----------------------------. 29 IQKCKITA.SSDLAPVKgsv....KTFLGRPWKLYSR--------------TVIMQSFIDNHIDp 30 IQNCNITA.SSDLDTATv......KTYLGRPWRIFST--------------VAVLQSFIGDLVDp 31 IQKCNITA.SSDLDTTTv......KTYLGRPWRIFST--------------VAVMQSFIGDLVDp 32 --------.--------.......----------------------------------------. 33 IHNCTVAP.NEDLKPVKaqf....KSYLGRPWKPHSR--------------TVVMESTIEDVIDp 34 VHNCKIAA.NEDLKPVKeey....KSYLGRPWKNYSR--------------TIIMESKIENVIDp 35 LQSCRIEP.DKDLVPVKnki....RSYLGRPWKEFSR--------------TVIMDSTIGDFIHp 36 LHGCHITG.DPAYIPMKsvn....KAYLGRPWKEFSR--------------TIIMKTTIDDVIDp 37 IHNSRITG.DASYLPVKakn....RAFLGRPWKEFSR--------------TIIMNTEIDDVIDp 38 FQGCTIAG.EPDYLAVKets....KAYLGRPWKEYSR--------------TIIMNTFIPDFVQp 39 IHASRVLA.ASDLQATNgst....QTYLGRPWKLFSR--------------TVYMMSYIGGHVHt 40 LHACIVEA.KY------.......PTYLGRPWKPFSR--------------VVVMESYLGAGVQp 41 IQNSYVLA.TQ------.......PTYLGRPWKLYSR--------------TVYMNTYMSQLVQp 42 IHNSVVKG.APGVQLGGv......KTYLGRPWRSYAR--------------TVVIGTYLDTLIEp 43 --------.--------.......----------------------------------------. 44 IHQCTISP.NGNVTA--.......TTYXGRPWKEY-----------------------------. 45 --------.--------.......----------------------------------------. 46 IQKCSISA.LN------.......----------------------------------------. 47 IQNCRIGG.TSDLLAVKgtf....PTYLGRPWKEYSR--------------TVIMQSDISDVIRp 48 IQNCRIGG.TSDLLAVKgtf....PTYLGRPWKEYSR--------------TVIMQSDISDVIRp 49 --------.--------.......----------------------------------------. 50 IQKCRIGA.TSDLQSVKgsf....PTYLGRPWKEYSQ--------------TVIMQSAISDVIRp 51 IQKSRIGA.TSDLKPVQgsf....PTYLGRPWKEYSR--------------TVIMQSSITDLIHp 52 IQKSRIGA.TSDLKPVQgsf....PTYLGRPWKEYSR--------------TVIMQSSITDLIHp 53 IQKSRIGA.TSDLKPVQgsf....PTYLGRPWKEYSR--------------TVIMQSSITDVIHp 54 IQNCRIGA.TSDLRPVQksf....PTYLGRPWKEYSR--------------TVIMQSSITDVINs 55 IQKCRIGA.TSDLRPVQksf....PTYLGRPWKEYSR--------------TVIMQSSITDVIQp 56 IQKCRIGA.TSDLRPVQksf....PTYLGRPWKEYSR--------------TVIMQSSITDVIQp 57 ILNCRILA.APDLIPVKenf....KAYLGRPWRKYSR--------------TVIIKSFIDDLIHp 58 IISSRILA.APDLIPVQanf....KAYLGRPWQLYSR--------------TVIMKSFIDDLVDp 59 IINCKVAA.AADLIPVKsef....RNYLGRPWKMYSR--------------TVFLNSLMEDLIEp 60 IHNSRVTA.ASDLRPVLgst....KTYLGRPWRQYSR--------------TVFMKTSLDSLIDp 61 IHNCRVTA.ASDLKPVQssv....KTFLGRPWKQYSR--------------TVXIKTFLDSLINp 62 IHNCRVTA.ASDLKPVQssv....KTFLGRPWKQYSR--------------TVYIKTFLDSLINp 63 IHGCTIRP.ADDLATSNytv....KTYLGRPWKEYSR--------------TVVMQTYIDGFLEp 64 IQNCTIKP.ADDLVSSNytv....KTYLGRPWKEYSR--------------TVYMQSYIDGFVEp 65 IYNCTIKP.ADDLVSSNytv....KTYXGRPWKEY-----------------------------. 66 IHNCTIKP.ADDLVSSNytv....KTYLGRPWKEYSR--------------TVFMQSYIDEVVEp 67 IINCTIKA.APDLAAEPksa....MTFLGRPWKPYSR--------------TVFMQSYISDIVQp 68 AVKGRF--.--------.......KSYLGRPWKKYSR--------------TVFLKTDIDELIDp 69 IQSSTVAT.AS------.......ETYLGRPWRSHSR--------------TVFMKCNLGALVSp 70 IQFSNIAA.DTDLLLNLntt....ATYLGRPWKLYSR--------------TVFMQNYMSDAINp 71 IQFSNISA.DSDLLASVnst....LSHLGRPW--------------------------------. 72 IQFCNITA.DSDLEAASvnst...PTYLGRPWKLYSR--------------TVIMQSFLSNVIRp 73 IQFSNISA.DADLVPYLntt....RTYLGRPWKLYSR--------------TVFIRNNMSDVVRp 74 IQQCNVIP.SSDLKPVQgsi....KTYLGRPWKKYSR--------------TVVLQSVVDSHIDp 75 IQQCNVIP.SSDLKPVQgsi....KTYLGRPWKKYSR--------------TVVLQSVVDSHIDp 76 -QQCNLTP.SSDLKAVVgsi....KTYLGRPWKKYSR--------------TVIMQSSIDSHIDp 77 IQQCNLTP.SSDLKAVVgsi....KTYLGRPWKKYSR--------------TVIMQSSIDSHIDp 78 IQQCNITP.SLDLKPVAgsi....KTYLGRPW--------------------------------. 79 IQNCDIIP.SSDLAPVKgsv....KTYLGRPW--------------------------------. 80 IQNCDIIP.SSDLAPVKgsv....KTYLGRPWKAYSR--------------TVFMQSNIGDHIDp 81 IQNCDIIP.SSDLAPVKgsv....KTYLGRPWKAYSR--------------TVFMQSNIGDHIDp 82 IQNCDIIP.SSDLAPVKgsv....KTYLGRPWKAYSR--------------TVFMQSNIGDHIDp 83 IQFCDIIA.SPDLEPVMney....KTYLGRPWKKHSR--------------TVVMQSYLDGHIDp 84 IQFCNIIA.SPDLEPVKney....KTYLGRPW--------------------------------. 85 IQFCDIIA.SPDLEPVVnef....KTYLGRPW--------------------------------. 86 IQFCDIIA.SPDLEPVVkef....KTYLGRPWKEYSR--------------TVVMQSYLGGLIDp 87 IQFCDIIA.SSDLEPLLkef....PTYLGRPWKEYSR--------------TVVMESYLGGLINp 88 IQFCNIIA.SSDLEPVLkef....PTYLGRPWKEYSR--------------TVVMESYLGGLINp 89 IQFCNIIA.SSDLEPVLkef....PTYLGRPWKEYSR--------------TVVMESYLGGLINp 90 IQFCNIIA.SSDLEPVLkef....PTYLGRPWKKYSR--------------TVVMESYLGGLINp 91 IQFCDIIA.SPDLKPVVkef....PTYLGRPWKKYSR--------------TVVMESYLGGLIDp 92 IQFCDIIA.SPDLKPVVkef....PTYLGRPWKKYSR--------------TVVMESYLGGLIDp 93 IQFCDIIA.SPDLKPVVkef....PTYLGRPWKKYSR--------------TVVMESSLGGLIDp 94 FIRGKVYG.ID------.......EVYLGRAKGPYSR--------------VIFAKTYLSKTVVp 95 --------.----VWST.......SVYLGRAYGPFSR--------------VIFIQTDLSSVVHp 96 FSDCTVTG.VG------.......KTLLGRAWGSNAR--------------VIFDRSRLSDVVLp 97 FKDCTVMG.SG------.......KALLGRAWKSYSR--------------VIFYRSMFSDNILp 98 FVNCTIGG.TG------.......HVWLGRAWRPYSR--------------VVFVSTTMTDVIAp 99 FVNCKIDG.SG------.......EILLGRAWGAYAT--------------VVFSNTYMSGIITp 100 FVNCKITG.SA------.......RVWLGRAWRPYAR--------------VIFSKTYMSRVVSl 101 FLGCKLTG.SG------.......STFLGRPWGAYSR--------------VVFAYSFFSNVVAp 102 FVHCKVTG.VGT-----.......GIYLGRAWMSHPK--------------VVYSYTEMSSVVNp 103 FVHCKVTG.TGT-----.......GIYLGRSWMSHPK--------------VVYAFTEMTSVVNp 104 FVHCKVTG.TGG-----.......GIYLGRAWMSHPK--------------VVYAYTEMTSVVNp 105 FVHCKVTG.TGG-----.......GIYLGRAWMSHPK--------------VVYAYTEMTSVVNp 106 ITNSRVIR.ESDSVPAK.......SYGLGRPWHPTTTFSDGRYADPNAIGQTVFLNTSMDNHIY. 107 ITNSRVIR.ESDSVPAK.......SYGLGRPWHPTTTFSDGRYADPNAIGQTVFLNTSMDNHIY. 108 ITNSRVIR.ESDSVPAK.......SYGLGRPWHPTTTFSDGRYADPNAIGQTVFLNTSMDNHIY. 109 AINSTFNA.TGNASNN-.......STHLGRAWDQGVSGTSAYINGSSPNGQVVIRDSSLGAHIR. 110 VINSQLTG.DNGYRGAQ.......KAKLGRAWD-------------------------------. 111 AVSCRFTG.DEGFSGGR.......KAKLGRAWDQGAR-QTGYQPNKTANGQLVIRDSTIDASYD. 112 VINSQLTG.DNGYRGAQ.......KAKLGRAWDQGAK-QTGYLPGKTANGQLVIRDSTIDSSYD. 113 AVNSRFNA.FGD----G.......VAQLGRSLDVDAN----------TNGQVVIRDSAINEGFN. 114 AVNSRFNA.FGD----G.......VAQLGRSLDVDAN----------TNGQVVIRDSAINEGFN. 115 FNKSKVSPaVGATVSSG.......VYYLGRPWGNYAR--------------VVFQHTDLSNVINp 116 INKSKVSAaSGNTVKAG.......AFYLGRPWRNYAR--------------VVFQNTAPSNVVNa 117 INKSTVAAkEGDDVAEG.......TYYLGRPWSEYAR--------------VVFQQTSMTNVINs 118 IHKSTVAAaDGNDVSSG.......TYYLGRPWSQYAR--------------VCFQKTSMTDVINh 119 IHKSSVAAaDGNDVPSG.......TYYLGRPWSQYAR--------------VLYQETSMTDVINs 280 290 300 310 320 | | | | | 1 .GTLLQ........DICIQ-----..---------...---NTAGPARDqaVALRVKWPGYHVIT 2 eGWKIW........DGE-------..-SFHKSCRY...VEYNNRGPGAF..ANRRVNWAKVARSA 3 eGWKIW........DGE-------..-SFHKSCRY...VEYNNRGPGAF..ANRRVNWAKVARSA 4 eGWKIW........DGE-------..-SFHKSCRY...VEYNNRGPGAI..TNRRVNWVKIARSA 5 eGWKIW........DGE-------..-SFHKSCRY...VEYNNRGPGAI..TNRRVNWVKIARSA 6 eGWTEW........QGE-------..-QNHKTAKY...IEFNNRGPGAA..TTQRPPWVKVAKSA 7 tGWNEW........QGE-------..-KFHLTATY...VEFNNRGPGAN..TAARVPWAKMAKSA 8 tGWNEW........QGE-------..-KFHLTATY...VEFNNRGPGAN..PAARVPWAKMAKSA 9 dGWLPW........SGD-------..-FALKTLYY...GESKNTGPGSD..RSQRVSWSSQIPDE 10 eGWLPW........SGD-------..-FALSTLYY...GEFGNSGPGAN..VSSRVPWSRLVPEE 11 lGWSPW........LRGSN-----..-FALNTVFY...GEYKNFGPGSS..TRWRVRWKGFHAIT 12 eGYMPM........VGG-------..-AFKDTCTF...YEYNNKGPGAD..TNLRVKWHGVKVLT 13 eGYMPW........MGS-------..-AFKETCTY...YEYNNKGPGAD..TNLRVKWHGVKVLT 14 eGYMPW........MGS-------..-AFKDTCTF...YEYNNKGPGAD..TSKRVKWPGVKSIS 15 eGYMPW........NGD-------..-FALKTLYY...AEYNNRGPGAG..TSKRVNWPGFHVIG 16 eGWAPW........NITN------..-FGRDTSYY...AEYQNRGPGAA..LDKRITWKGF---- 17 .-----........----------..---------...-----------..-------------- 18 .-----........----------..---------...-----------..-------------- 19 sGWSPW........SSN-------..-FALKTLYY...GEFGNSGPGSS..VSGRVSWAGYHPA- 20 sGWSPW........SGG-------..-FGLKSLFY...GEYGNSGPGSS..VSGRVKWSGCHPS- 21 sGWMSW........VSGV------..-DPPASIVY...GEYKNTGPGSD..VTQRVKWAGYKP-- 22 .-----........----------..---------...-----------..-------------- 23 vGWMSW........VPNV------..-EPPTTIFY...AEYQNSGPGAD..VSQRVKWAGYK--- 24 kGWLPW........TGD-------..-SAPDTIFY...GEYKNTGPGAS..TKNRVKWKGLRFLS 25 sGWSKW........NGG-------..-EALDTLYY...GEYNNNGPGSE..TVKRVNWPGFHIMG 26 .-----........----------..---------...---------AD..TSKRVGWKGYHTI- 27 mGWTPW........NSSTT-----..-GRLSTLYY...GEYKNKGPRAN..TSQRV--------- 28 .-----........----------..---------...-----------..-------------- 29 aGWFPW........DGE-------..-FALSTLYY...GEYANTGPGAD..TSKRVNWKGFKVIK 30 aGWTPW........EGE-------..-TGLSTLHY...REYQNRGPGAV..TSRRVKWSGFKVMK 31 aGWTPW........EGE-------..-TGLSTLHY...REYQNRGPGAV..TSRRVKWSGFKVMK 32 .-----........----------..---------...-----------..-------------- 33 vGWLRW........QETD------..-FAIDTLSY...AEYKNDGPSGA..TAARVKWPGFRVLN 34 vGWLRW........QETD------..-FAIDTLYY...AEYNNKGSSGD..TTSRVKWPGFKVIN 35 gGWLPW........QGD-------..-FGLKTLYY...AEYSNKGGGAQ..TNARIKWPGYHIIK 36 aGWLPW........SGD-------..-FALKTLYY...AEHMNTGPGSN..QAQRVKWPGIKKLT 37 eGWLKW........NET-------..-FALNTLFY...TEYRNRGRGSG..QGRRVRWRGIKRIS 38 qGWQPW........LGD-------..-FGLKTLFY...SEVQNTGPGSA..LANRVTWAGIKTLS 39 rGWLEW........NTT-------..-FALDTLYY...GEYLNSGPGSG..LGQRVSWPGYRVIN 40 rGWLEW........DGDG------..-GELATLFY...GEYRNYGPGAN..IGGRVRWPGYHVIM 41 rGWLEW........FGN-------..-FALDTLWY...GEYNNIGPGWR..SSGRVKWPGYHIMD 42 nGWIDW........DNV-------..-TALSTLYY...GEYQNSGPGSG..TENRVDWAGFHVIS 43 .-----........----------..---------...-----------..-------------- 44 .-----........----------..---------...-----------..-------------- 45 .-----........----------..---------...-----------..-------------- 46 .-----........----------..---------...-----------..-------------- 47 eGWHEW........SGS-------..-FALDTLTY...REYLNRGGGAG..TANRVKWKGYKVIT 48 eGWHEW........SGS-------..-FALDTLTY...REYLNRGGGAG..TANRVKWKGYKVIT 49 .-----........----------..---------...-----------..-------------- 50 eGWSEW........TGT-------..-FALNTLTY...REYSNTGAGAG..TANRVKWRGFKVIT 51 aGWHEW........DGN-------..-FALNTLFY...GEHQNSGAGAG..TSGRVKWKGFRVIT 52 aGWHEW........DGN-------..-FALNTLFY...GEHQNSGAGAG..TSGRVKWKGFRVIT 53 aGWHEW........DGN-------..-FALNTLFY...GEHQNAGAGAG..TSGRVKWKGFRVIT 54 aGWHEW........NGN-------..-FALNTLFY...GEYQNTGAGAG..TSGRVKWRGFKVIT 55 aGWHEW........NGN-------..-FALNTLFY...GEYANTGAGAA..TSGRVKWKGHKVIT 56 aGWHEW........NGN-------..-FALDTLFY...GEYANTGAGAP..TSGRVKWKGHKVIT 57 aGWLEG........KKD-------..-FALETLYY...GEYMNEGPGAN..MAKRVTWPGFRRIE 58 aGWLKW........KDD-------..-FALETLYY...GEYMNEGPGSN..MTNRVQWPGFKRIE 59 aGWLEW........NGT-------..-FALDTLYY...GEYNNRGPGAN..TSGRVTWPGYRVIT 60 rGWLEW........DGN-------..-FALKTLFY...AEFQNTGPGAS..TSGRVTWPGFRVL- 61 aGWMEW........SGD-------..-FALNTLYY...AEYMNTGPGSS..TANRVKWRGYHVLT 62 aGWMEW........SGD-------..-FALNTLYY...AEYMNTGPGSS..TANRVKWRGYHVLT 63 sGWNAW........SGD-------..-FALSTLYY...AEYNNTGPGSD..TTNRVTWPGYHVIN 64 vGWREW........NGD-------..-FALSTLYY...AEYNNTGPGSN..TTNRVTWPGYHVIN 65 .-----........----------..---------...-----------..-------------- 66 vGWREW........NGD-------..-FALSTLYY...AEYNNTGSGSS..TTDRVVWPGYHVIN 67 vGWLEW........NGT-------..-IGLDTIYY...GEYSNFGPGAN..TNQRVQWLGYNLLN 68 rGWREW........SGS-------..-YALSTLYY...GEFMNTGAGAG..TGRRVNWPGFHVLR 69 aGWLPW........SGS-------..-FALSTLYY...GEYGNTGAGAS..VSGRVKWPGYHVIK 70 vGWLEW........NGN-------..-FALDTLYY...GEYMNSGPGAS..LDRRVKWPGYHVLN 71 .-----........----------..---------...-----------..-------------- 72 eGWLEW........NGD-------..-FALNSLFY...GEYMNYGPGAG..LGSRVKWPGYQVFN 73 eGWLEW........NAD-------..-FALDTLFY...GEFMNYGPGSG..LSSRVKWPGYHVFN 74 aGWAEW........DAASK-----..-DFLQTLYY...GEYLNSGAGAG..TSKRVTWPGYHIIK 75 aGWAEW........DAASK-----..-DFLQTLYY...GEYLNSGAGAG..TSKRVTWPGYHIIK 76 tGWAEW........DAQSK-----..-DFLQTLYY...GEYMNSGAGAG..TSKRVNWPGYHIIT 77 tGWAEW........DAQSK-----..-DFLQTLYY...GEYMNSGAGAG..TSKRVNWPGYHIIT 78 .-----........----------..---------...-----------..-------------- 79 .-----........----------..---------...-----------..-------------- 80 eGWSVW........DGD-------..-FALKTLYY...GEYMNKGPGAG..TSKRVKWPGYHILS 81 eGWSVW........DGD-------..-FALKTLYY...GEYMNKGPGAG..TSKRVKWPGYHILS 82 eGWSVW........DGD-------..-FALKTLYY...GEYMNKGPGAG..TSKRVKWPGYHILS 83 sGWFEW........RGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHVIT 84 .-----........----------..---------...-----------..-------------- 85 .-----........----------..---------...-----------..-------------- 86 aGWAEW........SGE-------..-FALKTLYY...GEYMNNGPGAG..TSKRVKWPGYHVIT 87 aGWAEW........DGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHVIT 88 aGWAEW........DGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHVIT 89 aGWAEW........DGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHVIT 90 aGWAEW........DGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHCIT 91 sGWAEW........HGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHCIT 92 sGWAEW........HGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHVIT 93 sGWAEW........HGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHVIT 94 dGWTNW........SYH-------..-GSTQNLYH...GEYKCHGPGAE..RQKRSDWAKDLTKQ 95 eGWYSW........HYG-------..-GYEMSFTY...AEVECKGAGSD..MSRRVPWIDKLHSF 96 iGWDAW........RAK-------..-GNERDLTF...VEAGCTGAGAD..TSQRVPWLKKLSLS 97 iGWDAW........KAK-------..-GQEGHITF...VEFGCTGVGAD..TSKRVPWLTKASEK 98 eGWNNF........NDP-------..-SRDATIFY...GEYNCSGPGAD..MSKRAPYVQKLNET 99 eGWNNW........GDS-------..-TKEKTVTF...GEHKCYGPGAD..YKERVLFGKQLTDS 100 dGWNDM........GDP-------..-KTQRTVYY...GEHRCYGPGAN..HSKRVTYAKLLSDV 101 qGWNQW........GDS-------..-TKENTVYY...GEYKCYGPGAD..REQRVEWSKQLSDE 102 sGWQEN........RVR-------..-AHDKTVFY...GEYMCTGPGSH..KAKRVAHTQDIDNK 103 sGWREN........LNR-------..-GYDKTVFY...GEYKCFGPGSH..LEKRVPYTQDIDKN 104 tGWQEN........KTP-------..-AHDKTVFY...GEYKCSGPGSH..KAKRVPFTQDIDDK 105 tGWQEN........KTP-------..-AHDKTVFY...GEYKCSGPGSH..KAKRVPFTQDIDDK 106 .GWDKM........SGKDKNGNTI..WFNPEDSRF...FEYKSYGAGAA..VSKDRRQLTDAQAA 107 .GWDKM........SGKDKNGNTI..WFNPEDSRF...FEYKSYGAGAA..VSKDRRQLTDAQAA 108 .GWDKM........SGKDKNGNTI..WFNPEDSRF...FEYKSYGAGAT..VSKDRRQLTDAQAA 109 .LADPW........GPSTAGRPYCssKCAYSANRF...FEYNNTGAGS-..-------------- 110 .-----........----------..---------...-----------..-------------- 111 .REQPW........GVAATTARPF..AGNVD----...-----------..-------------- 112 .LANPW........GAAATTDRPF..KGNI-----...-----------..-------------- 113 .TAKPWada13agnTGSVDDNDEI..QRNLNDTNYnrmWEYNNRGVGSK..-------------- 114 .TAKPWada13agnTGSVDDNDEI..QRNLNDTNYnrmWEYNNRGVGSK..-------------- 115 qGWAAW........NTGD------..-ARTDHVLF...GEYQNTGAGAS..---GKRSFGQTLKA 116 kGWTQW........GSSD------..-PRTDKVTF...GEYGNTGDGAS..--GTRATFAKKLSS 117 lGWTEW........STST------..-PNTEYVTF...GEYANTGAGSE..--GTRASFAEKLDA 118 lGWTEW........STST------..-PNTENVTF...VEYGNTGTGAE..--GPRANFSSELTE 119 aGWSVW........STTQ------..-ANTENVTF...AEYGNTGAGAE..--GTRASFSEKLSE 330 340 | | 1 ---------------- 2 AEVNGFTAANWLGP-- 3 AEVNGFTAANWLGP-- 4 AEVNDFTVANWLGP-- 5 AEVNDFTVANWLGP-- 6 AEVETYTVANWVG--- 7 AEVERFTVANWLT--- 8 AEVERFTVANWLT--- 9 HV-------------- 10 HVS------------- 11 S--------------- 12 S--------------- 13 S--------------- 14 STEAAAF--------- 15 ---------------- 16 ---------------- 17 ---------------- 18 ---------------- 19 ---------------- 20 ---------------- 21 ---------------- 22 ---------------- 23 ---------------- 24 ---------------- 25 YE-------------- 26 ---------------- 27 ---------------- 28 ---------------- 29 D--------------- 30 DP-------------- 31 DP-------------- 32 ---------------- 33 KEEA------------ 34 KEE------------- 35 KEEA------------ 36 PQDALLYTGD------ 37 DRA------------- 38 EEDIL----------- 39 ---------------- 40 DA-------------- 41 KRT------------- 42 D--------------- 43 ---------------- 44 ---------------- 45 ---------------- 46 ---------------- 47 ---------------- 48 ---------------- 49 ---------------- 50 ---------------- 51 SA-------------- 52 SA-------------- 53 SA-------------- 54 S--------------- 55 S--------------- 56 S--------------- 57 NQ-------------- 58 TV-------------- 59 N--------------- 60 ---------------- 61 SP-------------- 62 SP-------------- 63 AT-------------- 64 S--------------- 65 ---------------- 66 S--------------- 67 ---------------- 68 ---------------- 69 TV-------------- 70 ---------------- 71 ---------------- 72 EST------------- 73 N--------------- 74 ---------------- 75 ---------------- 76 S--------------- 77 ---------------- 78 ---------------- 79 ---------------- 80 AAE------------- 81 AAE------------- 82 AAE------------- 83 D--------------- 84 ---------------- 85 ---------------- 86 D--------------- 87 D--------------- 88 D--------------- 89 D--------------- 90 D--------------- 91 D--------------- 92 D--------------- 93 D--------------- 94 EVESFLS--------- 95 YTKQQFSISNF----- 96 EVDGF----------- 97 DVLQFT---------- 98 Q--------------- 99 EASS------------ 100 EAAPF----------- 101 EATVF----------- 102 EASQFLTLG------- 103 EVTPFLTLG------- 104 EANRFLSLG------- 105 EANCFLSLG------- 106 EYTQSKVLGDWTPTLP 107 EYTQSKVLGDWTPTLP 108 EYTQSKVLGDWTPTLP 109 ---------------- 110 ---------------- 111 ---------------- 112 ---------------- 113 ---------------- 114 ---------------- 115 ALSITDILGSNYKDW- 116 AVSISTVLGSSYKNW- 117 KLTITDILGSDYTSW- 118 PITISWLLGSDWEDW- 119 PVAISTILGSDWAQW-