; SAM: prettyalign v3.1b (February 24, 1999) compiled 04/18/00_11:44:15 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ------ Citations (HMMs, SAM) ------ ; A. Krogh et al., Hidden Markov models in computational biology: ; ------------- Citations (SAM, SAM-T99, HMMs) ----------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; -------------------------------------------------------------- ; Sequence numbers correspond to the following labels: ; 1 T0100 ; 2 gi|6689890|gb|AAF23891.1|_213:498 ; 3 gi|7489091|pir||T16976_1:288 ; 4 gi|7489090|pir||T16975_1:288 ; 5 gi|6174913|sp|P14280|PME1_LYCES_229:514 ; 6 gi|1256267|gb|AAB67740.1|_113:398 ; 7 gi|7447380|pir||T10492_269:555 ; 8 gi|6174912|sp|O04886|PME1_CITSI_269:555 ; 9 gi|1617588|gb|AAB38794.1|_122:407 ; 10 gi|6093734|sp|Q96575|PM22_LYCES_234:518 ; 11 gi|2507165|sp|P09607|PM21_LYCES_234:518 ; 12 gi|1256263|gb|AAB67739.1|_234:518 ; 13 gi|6056392|gb|AAF02856.1|AC009324_5_272:556 ; 14 gi|6689892|gb|AAF23892.1|AF152172_1_261:546 ; 15 gi|82097|pir||S00629_58:342 ; 16 gi|2895510|gb|AAC72288.1|_277:561 ; 17 gi|6093740|sp|Q43143|PMEU_LYCES_268:553 ; 18 gi|7447367|pir||S78456_3:289 ; 19 gi|6093744|sp|Q43062|PME_PRUPE_205:492 ; 20 gi|7447366|pir||T01317_257:542 ; 21 gi|6056422|gb|AAF02886.1|AC009525_20_263:548 ; 22 gi|130346|sp|P07863|PMEA_ERWCH_26:366 ; 23 gi|478290|pir||JN0799_26:366 ; 24 gi|6714532|dbj|BAA89480.1|_283:571 ; 25 gi|2583131|gb|AAB82640.1|_202:479 ; 26 gi|7447368|pir||S72525_2:285 ; 27 gi|6093738|sp|Q96576|PME3_LYCES_228:512 ; 28 gi|7447375|pir||T05202_161:445 ; 29 gi|7549630|gb|AAF63815.1|_247:542 ; 30 gi|6093737|sp|Q42534|PME2_ARATH_267:551 ; 31 gi|7447372|pir||T06468_237:523 ; 32 gi|6174914|sp|O04887|PME2_CITSI_198:481 ; 33 gi|7447371|pir||T06374_237:523 ; 34 gi|7447381|pir||T10494_198:481 ; 35 gi|7447365|pir||T01318_203:489 ; 36 gi|7447387|pir||T02184_273:573 ; 37 gi|6630558|gb|AAF19577.1|AC011708_20_300:583 ; 38 gi|7447386|pir||T02183_280:580 ; 39 gi|6723392|emb|CAB66401.1|_280:565 ; 40 gi|6093122|emb|CAB58974.1|_280:580 ; 41 gi|7485174|pir||G71425_387:675 ; 42 gi|3342904|gb|AAC27719.1|_273:571 ; 43 gi|6630559|gb|AAF19578.1|AC011708_21_253:531 ; 44 gi|6093743|sp|Q43043|PME_PETIN_54:335 ; 45 gi|6899927|emb|CAB71877.1|_272:572 ; 46 gi|7447376|pir||T00978_179:467 ; 47 gi|7447384|pir||T04359_247:531 ; 48 gi|1172538|sp|P41510|PME_BRANA_268:568 ; 49 gi|6714449|gb|AAF26136.1|AC011620_12_251:540 ; 50 gi|7447370|pir||T00429_153:439 ; 51 gi|7329683|emb|CAB82677.1|_192:465 ; 52 gi|7447369|pir||T00977_235:519 ; 53 gi|7447389|pir||T01418_218:503 ; 54 gi|7447390|pir||T05203_292:581 ; 55 gi|2829892|gb|AAC00600.1|_247:525 ; 56 gi|4531441|gb|AAD22126.1|AC006224_8_210:484 ; 57 gi|6714448|gb|AAF26135.1|AC011620_11_238:514 ; 58 gi|7649367|emb|CAB89048.1|_212:494 ; 59 gi|6093741|sp|Q42608|PME_BRACM_255:555 ; 60 gi|6048277|emb|CAB57457.2|_2:255 ; 61 gi|6093742|sp|Q42920|PME_MEDSA_127:411 ; 62 gi|7529744|emb|CAB86929.1|_224:496 ; 63 gi|6093736|sp|Q43867|PME1_ARATH_276:554 ; 64 gi|7447391|pir||T01870_214:507 ; 65 gi|7447388|pir||T01347_162:444 ; 66 gi|6688852|emb|CAB65291.1|_245:529 ; 67 gi|6093739|sp|Q43111|PME3_PHAVU_270:547 ; 68 gi|7671413|emb|CAB89354.1|_237:532 ; 69 gi|7447382|pir||T12995_277:564 ; 70 gi|7489092|pir||T16977_5:247 ; 71 gi|5922617|dbj|BAA84618.1|_300:579 ; 72 gi|6688851|emb|CAB65290.1|_227:517 ; 73 gi|6554203|gb|AAF16649.1|AC011661_27_43:298 ; 74 gi|7025485|gb|AAF35897.1|AF229849_1_1:246 ; 75 gi|6554192|gb|AAF16638.1|AC011661_16_213:522 ; 76 gi|4415916|gb|AAD20147.1|_87:372 ; 77 gi|4415915|gb|AAD20146.1|_38:321 ; 78 gi|7447362|pir||T07181_1:216 ; 79 gi|7447363|pir||T07183_2:219 ; 80 gi|4567229|gb|AAD23644.1|AC007119_10_47:320 ; 81 gi|100008|pir||S25171_2:217 ; 82 gi|7576181|emb|CAB87932.1|_63:347 ; 83 gi|2388565|gb|AAB71446.1|_87:370 ; 84 gi|1552379|emb|CAA69348.1|_93:361 ; 85 gi|4514622|dbj|BAA75474.1|_25:324 ; 86 gi|7488000|pir||T00536_37:321 ; 87 gi|130345|sp|P17872|PME_ASPTU_25:324 ; 88 gi|7576179|emb|CAB87930.1|_46:328 ; 89 gi|6358800|gb|AAF07380.1|AC010675_3_50:324 ; 90 gi|7576180|emb|CAB87931.1|_63:347 ; 91 gi|5802953|gb|AAD51853.1|AF178989_1_34:329 ; 92 gi|5442422|gb|AAD43340.1|AF159252_1_35:331 ; 93 gi|1084429|pir||S46296_2:219 ; 94 gi|7670030|dbj|BAA94984.1|_42:326 ; 95 gi|2499454|sp|Q12535|PME_ASPAC_25:325 ; 96 gi|100010|pir||S25172_2:215 ; 97 gi|7447385|pir||T09823_2:215 ; 98 gi|6554191|gb|AAF16637.1|AC011661_15_1:193 ; 99 gi|7488907|pir||T10488_46:261 ; 100 gi|130347|sp|P24791|PME_BURSO_75:394 ; 101 gi|5734773|gb|AAD50038.1|AC007980_3_155:344 ; 102 gi|7489089|pir||T16974_5:183 ; 103 gi|2507166|sp|P46130|YBHC_ECOLI_77:420 ; 104 gi|4062339|dbj|BAA35436.1|_45:388 ; 105 gi|2499456|sp|Q47474|PMEB_ERWCH_84:408 ; 106 gi|2275206|gb|AAB63828.1|_14:226 ; 107 gi|7485253|pir||T01761_30:231 ; 108 gi|82096|pir||A25010_3:272 ; 109 gi|7767677|gb|AAF69174.1|AC007915_26_55:217 ; 110 gi|2121037|pir||S70913_20:179 ; 111 gi|2499455|sp|P55743|PMEB_ERWCA_3:156 ; 112 gi|5566248|gb|AAD45347.1|_2:96 ; 113 gi|5566252|gb|AAD45348.1|_1:75 ; 114 gi|1932927|gb|AAB51702.1|_2:98 ; 115 gi|6554190|gb|AAF16636.1|AC011661_14_265:350 ; 116 gi|2895514|gb|AAC02974.1|_2:78 ; 117 gi|2895512|gb|AAC02973.1|_2:78 ; 118 gi|1932925|gb|AAB51701.1|_2:84 ; 119 gi|2895516|gb|AAC02975.1|_2:73 10 20 30 40 50 | | | | | 1 ATTYNAVVSKSSSDGKTFKTIADAIASAPAGS....TPFVILIKNGVYNER.LTIT..RNNLHLK 2 DIKANAVVAQDGTG--DYQTLAEAVAAAPDKSk...TRYVIYVKMGIYKEN.VEVTsrKMNLMIV 3 AITANVVVANDGSG--KYKTIKEAVASVPDNSn...SRYVIYVKKGIYKEN.VEIGkkKKNVMLV 4 AITANVIVAKDGSG--KYKTVKEAVASVPDNSn...SRYVIYVKKGIYKEN.VEIGkkKKNVMLV 5 DIIANAVVAQDGTG--DYQTLAEAVAAAPDKSk...TRYVIYVKRGTYKEN.VEVAsnKMNLMIV 6 DIIANAVVAQDGTG--DYQTLAEAVAAAPDKSk...TRYVIYVKRGTYKEN.VEVSsnKMNLMIV 7 SVTPNAVVAADGSG--NFKTVAAAVAAAPQGGt...KRYIIRIKAGVYREN.VEVTkkHKNIMFI 8 SVTPNAVVAADGSG--NFKTVAAAVAAAPQGGt...KRYIIRIKAGVYREN.VEVTkkHKNIMFI 9 DIIANRVVAQDGTG--KYRTLAEAVAAAPNRSk...KRYVIYVKRGIYKEN.VEVSsnKMNLMIV 10 -IGANAVVAKDGTG--KYRTLAEAVAAAPDKSk...TRYVIYVKRGIYKEN.VEVSsrKMKLMIV 11 -IGANAVVAKDGTG--KYRTLAEAVAAAPDKSk...TRYVIYVKRGTYKEN.VEVSsrKMNLMII 12 -IGANAVVAKDGTG--KYRTLAEAVAAAPDKSk...TRYVIYVKRGTYKEN.VEVSsrKMNLMII 13 TIKADATVADDGSG--DFTTVAAAVAAAPEKSn...KRFVIHIKAGVYREN.VEVTkkKTNIMFL 14 TVTPDVVVAADGSG--DYKTVSEAVAKAPEKSs...KRYVIRIKAGVYREN.VDVPkkKTNIMFM 15 -IGANAVVAKDGTG--KYRTLAEAVAAAPDKSk...TRYVIYVKRGTYKEN.VEVSsrKMNLMII 16 GVKRDATVAADGSG--TFKTVAAAVAAAPENSn...KRYVIHIKAGVYREN.VEVAkkKKNIMFM 17 TVTPDVVVAADGSG--DYKTVSEAVRKAPEKSs...KRYVIRIKAGVYREN.VDVPkkKTNIMFM 18 DVKANVVVAQDGSG--KFKTVTEAVASAPDNGk...TRYVIYVKKGTYKEH.VEIGkkKKNIMLV 19 -VSVDAIVAQDGTG--NFTNVTDAVLAAPDYSm...RRYVIYIKRGTYKEN.VEIKkkKWNLMMI 20 ---DIVTVNQNGTG--NFTTITEAVNSAPNKTdgtaGYFVIYVTSGVYEEN.VVIAknKRYLMMI 21 ---DIVTVSQDGTG--NFTNITAAVAAAPNNTdgsaGFFLIYVTAGIYEEY.ISIAknKRYMMMI 22 -TTYNAVVSKSSSDGKTFKTIADAIASAPAGS....TPFVILIKNGVYNER.LTIT..RNNLLLK 23 -TTYNAVVSKSSSDGKTFKTIADAIASAPAGS....TPFVILIKNGVYNER.LTIT..RNNLHLK 24 KPKPNVSVAKDGSG--DFKTISEALAAMPAKYe...GRYVIFVKQGVYDET.VTVTkkMANITMY 25 -PKDNAVVAKDGSG--NFKTIKEAIDAAS-GS....GRFVIYVKQGVYSEN.LEIR..KKNVMLR 26 --KANVVVAQDGSG--KFKTVTEAVASAPDNGk...TRYVIYVKKGTYKEH.VEIGkkKKNIMLV 27 DIIANRVVAQDGTG--DYQTLAEAVAAAPDKNk...TRYVIYVKMGIYKEN.VVVTkkKMNLMIV 28 -RTYDVSVALDGTG--NFTKIMDAIKKAPDYSs...TRFVIYIKKGLYLEN.VEIKkkKWNIVML 29 PVKANAVVAQDGTG--QFKTITDALNAVPKGNk...VPFIIHIKEGIYKEK.VTVTkkMPHVTFI 30 TIKADATVADDGSG--DFDNGSAAVAAAPEKSn...KRFVIHIKAGVYREN.VEVTkkKTNIMFL 31 DIKANVVVAKDGSG--KFKTVAEAVASAPDNGk...ARYVIYVKRGTYKEK.VEIGkkKTNVMLV 32 TPRANIVVAQDGSG--NVKTIQEAVAAASRAGg...SRYVIYIKAGTYNEN.IEVK..LKNIMFV 33 DIKANVVVAKDGSG--KFKTVAEAVASAPDNGk...ARYVIYVKRGTYKEK.VEIGkkKTNVMLV 34 TPRANIVVAQDGSG--NVKTIQEAVAAASRAGg...SRYVIYIKAGTYNEN.IEVK..LKNIMFV 35 ETKVNLVVAQNGTG--NYTTIGEAISAAPNSSe...TRFVIYIKCGEYFEN.IEIPreKTMIMFI 36 -VRTNFVVAKDGSG--QFKTVQQAVDACPENNr...GRCIIYIKAGLYREQ.VIIPkkKNNIFMF 37 ----AVIVGPFKSD--NFTTITDAIAAAPNNTrpedGYFVIYAREGVYEEY.IVVPinKKNLMLM 38 -IRATFVVAKDGSG--QFKTVQQAVNACPEKNp...GRCIIHIKAGIYREQ.VIIPkkKNNIFMF 39 QIQADIIVSKDGNG--TCKTISEAIKKAPQNSt...RRIIIYVKAGRYEENnLKVGrkKINLMFV 40 -IRATFVVAKDGSG--QFKTVQQAVNACPEKNp...GRCIIHIKAGIYREQ.VIIPkkKNNIFMF 41 GIKANVVVAKDGSG--KCKTIAQALAMVPMKNt...KKFVIHIKEGVYKEK.VEVTkkMLHVMFV 42 -VRTNFVVAKDGSG--QFKTVQQAVDACPENNr...GRCIIYIKAGLYREQ.VIIPkkKNNIFMF 43 --VADIVVAKDGSG--KYRTIKRALQDVPEKSe...KRTIIYVKKGVYFEN.VKVEkkMWNVIVV 44 NAKPNATVALDGSG--QYKTIKEALDAVPKKNt...EPFIIFIKAGVYKEY.IDIPksMTNVVLI 45 KIKATHVVAKDGSG--QFKTISEAVMACPDKNp...GRCIIHIKAGIYNEQ.VRIPkkKNNIFMF 46 ALKPNATVAKDGSG--DFTTINDALRAMPEKYe...GRYIIYVKQGIYDEY.VTVDkkKANLTMV 47 QPKPNAIVAKDGSG--QFKSIQQAVDAVPKGHq...GRYVIYVKAGLYDEI.VMVPkdKVNIFMY 48 KIKPTHVVAKDGSG--QFKTISEAVKACPEKNp...GRCIIYIKAGVYKEQ.VTIPkkVNNVFMF 49 DVKPDIVVAQDGSG--QYKTINEALQFVPKKRn...TTFVVHIKAGLYKEY.VQVNktMSHLVFI 50 ---DIVTVIQNGTG--NFTTINAAIAAAPNKTdgsnGYFLIYVTAGLYEEY.VEVPknKRYVMMI 51 -SRADFVVARDGSA--THRTINQALAAVSRMGksrlNRVIIYIKAGVYNEK.IEIDrhMKNIMLV 52 --SESLVVAADGTG--NFSTINEAISFAPNMSn...DRVLIYVKEGVYDEN.IDIPiyKTNIVLI 53 -TNYNLSVAIDGTG--NFTTINDAVFAAPNMSe...TRFIIYIKGGEYFEN.VELPkkKTMIMFI 54 ALKPNATVAKDGSG--NFTTINAALKAMPAKYq...GRYTIYIKHGIYDES.VIIDkkKPNVTMV 55 -AKADLVVAKDGSG--HYTSIQQAVNAAAKLPrrn.QRLVIYVKAGVYREN.VVIKksIKNVMVI 56 -LNVDAVVAPDGSG--THKTIGEALLSTSLASsg..GRTKIYLKAGTYHEN.INIPtkQKNVMLV 57 --HPNTVVAIDGKG--KYRTINEAINEAPNHSt...KRYVIYVKKGVYKEN.IDLKkkKTNIMLV 58 --VADAVVAADGTG--NFTTISDAVLAAPDYSt...KRYVIHVKRGVYVEN.VEIKkkKWNIMMV 59 KIKPTHVVAKDGSG--QFKTISEAVKACPEKNp...GRCIIYIKAGVYKEQ.VTIPkkVNNVFMF 60 --------------------------------....-RYVIRIKAGVYREN.VDVPkkKTNIMFM 61 NVQPNAVVAQDGSG--QFKTLTDALKTVPPKNa...VPFVIHVKAGVYKET.VNVAkeMNYVTVI 62 ELRPHAVVAADGSG--THMSVAEALASLEKGS....GRSVIHLTAGTYKEN.LNIPskQKNVMLV 63 GLKPDVTVAGDGTG--DVLTVNEAVAKVPKKSl...KMFVIYVKSGTYVEN.VVMDksKWNVMIY 64 --IADVVVAKDGTG--KYNTVNAAIAAAPQHSh...KRFIIYIKTGIYDEI.VAIEntKPNLTLI 65 --KVDVVVAQDGSG--DYKTIQEAVNGAGERLkgs.PRYVIHVKQGVYEEY.VNVGikSNNIMIT 66 NVKANAVVAQDGSG--QFKTLTDALKTVPPTNa...APFVIYVKAGVYKET.VNVAkeMNYVTVI 67 -STPDAVVAKDGSG--QFKTIGEALKLVKKKSe...ERFSVYVKEGRYVEN.IDLDknTWNVMIY 68 -LKEDVTVCKDGKC--GYKTVQDAVNAAPEDNgm..RKFVIKISEGVYEEN.VIVPfeKKNVVFI 69 -SSPHLVVAQDRSG--HFRSIQAAINFAARRRfk..SRFVIYVKKGVYREN.IDVGndNHNIMLV 70 --------------------------------....--------------N.VEIGkkKKNVMLV 71 AMRVDVVVAQDGSG--RWRTVSEAVARAPSHSr...RRYVIYVKRGVYEEN.VEVRkkKTNIVIV 72 TVKPNVVVAQDGSG--QFKTLTDAIKTVPANNa...QNFVIYVKEGVYNET.VNVPkdMAFVTII 73 --KADLIVAKDGSG--NFTTVNEAVAAAPENGv...KPFVIYIKEGLYKEV.IRIGkkKTNLTLV 74 --------------------------------....---------GAYFEN.VEVIrrKTNLMWV 75 --IADVVVAKDGTG--KYSTVNAAIAAAPQHSq...KRFVIYIKTGIYDEI.VVIEntKPNLTLI 76 -TSLVLTVDLHGCG--NFSNVQSAIDVVPDLSs...SKTLIIVNSGSYREK.VTVNenKTNLVIQ 77 -FTMVLKVSLNGCG--RFKRVQDAIDASIGSSq...SKTLILIDFGIYRER.FIVHenKNNLVVQ 78 --------AKDGSG--KYKTLLEAVASAPDNSk...TRFVIYVKKGTYKEN.VEIGkkKKNIMLV 79 ------VVAKDGTG--DYQTLAEAVAAAPDRSk...TRYVIYVKMGIYKEN.VEVTsrKMNLMIV 80 -TAILIRVDQSGKG--DFSKIQEAIESIPPNLnns.QLYFIWVKPGIYREK.VVIPaeKPYITLS 81 ------VVAKDGSG--KFKTVAEAVASAPDN-....RRYVIYVKKGTYKEN.VEIGkkKKNVMLV 82 -ARQIITVNQKGGA--NFKTLNEAIKSIPTGNk...NRVIIKLAPGVYNEK.VTIDiaRPFITLL 83 -TTSYLCVDKNGCC--NFTTVQSAVDAVGNFSq...RRNVIWINSGI--EK.VVIPktKPNITLQ 84 --------------------------------kgg.DRFVIRIKEGVYEET.VRAGfyKTNLVFL 85 --AGAIVVAKSGGD---YDTLSAAVNALSTTEt...ATQTIFIEEGTYDEQ.VYIPslAGKLIIY 86 -IAKTIIVNPNDAR--YFKTVQSAIDSIPLQNq...DWIRILISNGIYSEK.VTIPrgKGYIYMQ 87 --SGAIVVAKSGGD---YDTISAAVDALSTTSt...ETQTIFIEEGSYDEQ.VYIPalSGKLIVY 88 ---RIINVNPKGGE---FKTLTDAIKSVPAGNt...KRVIIKMAHGEYREK.VTIDrnKPFITLM 89 --------------GGEFKTLTDAIKSVPAGNt...KRVIIKMAPGEYKEK.VTIDrnKPFITLM 90 -SRRVIIVNQNGGG--DFKTINAAIKSIPLANk...NRVIIKLAPGIYHEK.VTVDvgRPYVTLL 91 -----GCLSVGSSG--TYKTVSAAVAKLSTSSt...TAQCIFIYKGTYKEQ.VYVPalKSALTIY 92 ---PAGCLTVGGSG--KYKTVQSAVNALDKSTs...KAQCIFIAKGTYTEQ.VYIQqlNSPLTIY 93 ------TVALDGSG--QYKTIKEALDAVPKKNt...EPFIIFIKAGVYKEY.IDIPksMTNVVLI 94 -TNRSIIVDIEGKG--DYTSVQKAIDAVPVGNs...NWIIVHVRKGIYKER.VHIPenKPFIFMR 95 --SGAIVVAKSGGD---YTTIGDAIDALSTSTt...DTQTIFIEEGTYDEQ.VYLPamTGKVIIY 96 ------VVAKDGSG--QFKTIGEALKLVKKKSe...KRFSVYVKEGRYVEN.IDLDknTWNVMIY 97 ------VVAKDGTG--NFQTVKEAMDAAD-GK....KRFVIYVKAGVYKEK.IHSN..KDGITLI 98 --------------------------------....---------------.----..------- 99 SVTPNVVVAADGSG--NFKTVAAAVAAAPQGGt...KRYIIRIKAGVYREN.VEVTkkHKNIMFI 100 GFRANYAVAADGSA--QYKTVQAAIDAAVADGgv..ARKYISVKAGTYNEL.VCVPesAPPITLY 101 --------------------------------....---------------.----..------- 102 --------------------------------....--------------N.VEVTkkKMNLMIV 103 PAQPDFVVGPAGTQGVTHTTIQAAVDAAIIKRtn..KRQYIAVMPGEYQGT.VYVPaaPGGITLY 104 PAQPDFVVGPAGTQGVTHTTIQAAVDAAIIKRtn..KRQYIAVMPGEYQGT.VYVPaaPGGITLY 105 -TAAYVVGPRAGVAGATHTSIQQAVNAALRQHpgq.TRVYIKLLPGTYTGT.VYVPegAPPLTLF 106 QIAYTITVDLNGGG--NFTTVQSAIDSISPPNh...NWIRVFTQNGIYR--.----..------- 107 -VVNTIVVDQAGSG--KFRTVQAAIDSVGELNs...LWIKIKVKRGVYN--.----..------- 108 ---ANAVVAQDGTG--DYQTLAEAVAAAPDKSk...TRYVIYVKRGTYKEN.VEVAsnKEFPTYL 109 --ITDILVAKDVTG--NYNIVNVAIAAAPQHSq...KRFVIYIKTSIYVEI.VVIGnmKSNLTLI 110 --------------------------------....---------------.----..------- 111 --------------------------------....---------------.----..------- 112 --------------------------------....---------------.----..------- 113 --------------------------------....---------------.----..------- 114 ------TVAADGSG--TFKTVAAAVAAAPENSn...KRYVIHIKAGVYREN.VEVAkkKKNXMFM 115 HVTANVVVAKDGTG--KFKTVNEAVAAAPENSn...TRYVIYVKKGVYKET.IDIGkkKKNLMLV 116 --------------------------------....---------------.----..------- 117 --------------------------------....---------------.----..------- 118 ------TVAADGSG--TFKTVAAAVAAAPENSn...KRYVIHIKAGVYREN.VEVAkkKKNIMFM 119 --------------------------------....---------------.----..------- 60 70 80 90 100 | | | | | 1 ..GESRNGAVIAAATAAGTLKSDGS........KW..GTAGSSTI........TISAKDFSAQSL 2 ..GDGMNATIITGSLNY------VD........GT..TTFRSATL........AAVGQGFILQDI 3 ..GDGMDATIITGNLNV------VD........GA..TTFNSATV........AAVGDGFIAQDV 4 ..GDGMDATIITGNLNV------VD........GA..TTFNSATV........AAVGDGFIAQDV 5 ..GDGMYATTITGSLNV------VD........GS..TTFRSATL........AAVGQGFILQDI 6 ..GDGMYATTITGSLNV------VD........GS..TTFRSATL........AAVGQGFILQDI 7 ..GDGRTRTIITGSRNV------VD........GS..TTFKSATV........AVVGEGFLARDI 8 ..GDGRTRTIITGSRNV------VD........GS..TTFKSATA........AVVGEGFLARDI 9 ..GDGMYATTITGSLNV------VD........GS..TTFRSATL........AAVGQGFILQDI 10 ..GDGMHATIITGNLNV------VD........GS..TTFHSATL........AAVGKGFILQDI 11 ..GDGMYATIITGSLNV------VD........GS..TTFHSATL........AAVGKGFILQDI 12 ..GDGMYATIITGSLNV------VD........GS..TTFHSATL........AAVGKGFILQDI 13 ..GDGRGKTIITGSRNV------VD........GS..TTFHSATV........AAVGERFLARDI 14 ..GDGRSNTIITASRNV------QD........GS..TTFHSATV........AAVGEKFLARDI 15 ..GDGMYATIITGSLNV------VD........GS..TTFHSATL........AAVGKGFILQDI 16 ..GDGRTRTIITGSRNV------VD........GS..TTFHSATV........AAVGERFLARDI 17 ..GDGKSNTIITASRNV------QD........GS..TTFHSATV........VRVAGKVLARDI 18 ..GDGMDATIITGSLNF------ID........GT..TTFNSATV........AAVGDGFIGQDI 19 ..GDGMDATIISGNRSF------VD........GW..TTFRSATF........AVSGRGFIARDI 20 ..GDGINRTVVTGNRNV------VD........GW..TTFNSATF........AVTSPNFVAVNM 21 ..GDGINQTVVTGNRSV------VD........GW..TTFNSATF........AVTAPNFVAVNI 22 ..GESRNGAVIAAATAAGTLKSDGS........KW..GTAGSSTI........TISAKDFSAQSL 23 ..GESRNGAVIAAATAAGTLKSDGS........KW..GTAGSSTI........TISAKDFSAQSL 24 ..GDGSQKTIVTGNKNF------AD........GV..QTFRTATF........AVLGDGFLCKFM 25 ..GDGIGKTIITGSKSV------GG........GT..TTFNSATV........AAVGDGFIARGI 26 ..GDGMDATIITGSLNF------ID........GT..TTFNSATV........AAVGDGFIGQDI 27 ..GDGMNATIITGSLNV------V-........DG..STFPSNTL........AAVGQGFILQDI 28 ..GDGIDVTVISGNRSF------ID........GW..TTFRSATF........AVSGRGFLARDI 29 ..GDGPNKTLITGSLNFG-----IG........KV..KTFLTATI........TIEGDHFTAKNI 30 ..GDGRGKTIITGSRNV------VD........GS..TTFHSATV........AAVGERFLARDI 31 ..GDGMDATIITGNLNF------ID........GT..TTFNSATV........AAVGDGFIAQDI 32 ..GDGIGKTIITGSKSV------GG........GA..TTFKSATV........AVVGDNFIARDI 33 ..GDGMDATIITGNLNF------ID........GT..TTFNSATV........AAVGDGFIAQDI 34 ..GDGIGKTIITGSKSV------GG........GA..TTFKSATV........AVVGDNFIARDI 35 ..GDGIGRTVIKANRSY------AD........GW..TAFHSATV........GVRGSGFIAKDL 36 ..GDGARKTVISYNRSVAL----SR........GT..TTSLSATV........QVESEGFMAKWM 37 ..GDGINKTIITGNHNV------VD........GW..TTYNCSSF........AVVGERFMAVDV 38 ..GDGARKTVISYNRSVKL----SP........GT..TTSLSGTV........QVESEGFMAKWI 39 ..GDGKGKTVISGGKSI------FD........NI..TTFHTASF........AATGAGFIARDI 40 ..GDGARKTVISYNRSVKL----SP........GT..TTSLSGTV........QVESEGFMAKWI 41 ..GDGPTKTVITGDIAFL-----PD........QV..GTYRTASV........AVNGDYFMAKDI 42 ..GDGARKTVISYNRSV------AL........SR..GTTTSLSA........TVESEGFMAKWM 43 ..GDGESKSIVSGRLNV------ID........GT..PTFKTATF........AVFGKGFMARDM 44 ..GEGPTKTKITGNKSV------KD........GP..STFHTTTV........GVNGANFVAKNI 45 ..GDGATQTIITFDRSVKL----SP........GT..TTSLSGTV........QVESEGFMAKWI 46 ..GDGSQKTIVTGNKSH------AK........KI..RTFLTATF........VAQGEGFMAQSM 47 ..GDGPKQSRVTGRKSF------AD........GI..TTMKTATF........SVEASGFICKNM 48 ..GDGATQTIITFDRSVGL----SP........GT..TTSLSGTV........QVESEGFMAKWI 49 ..GDGPDKTIISGNKNY------KD........GI..TTYRTATV........AIVGNYFIAKNI 50 ..GDGINQTVITGNRSV------VD........GW..TTFNSATF........ILSGPNFIGVNI 51 ..GDGMDRTIVTNNRNV------PD........GS..TTYGSATF........GVSGDGFWARDI 52 ..GDGSDVTFITGNRSV------GD........GW..TTFRSATL........AVSGEGFLARDI 53 ..GDGIGKTVIKANRSR------ID........GW..STFQTPTV........GVKGKGYIAKDI 54 ..GDGSQKTIVTGNKSH------AK........KI..RTFLTATF........VAQGEGFMAQSM 55 ..GDGIDSTIVTGNRNV------QD........GT..TTFRSATF........AVSGNGFIAQGI 56 ..GDGKGKTVIVGSRSN------RG........GW..TTYKTATV........AAMGEGFIARDM 57 ..GDGIGQTIITGDRNF------MQ........GL..TTFRTATV........AVSGRGFIAKDI 58 ..GDGIDATVITGNRSF------ID........GW..TTFRSATF........AVSGRGFIARDI 59 ..GDGATQTIITFDRSVGL----SP........GT..TTSLSGTV........QVESEGFMAKWI 60 ..GDGRSNTIITGSRNV------KD........GS..TTFNSATV........AAVGEKFLARDI 61 ..GDGPTKTKFTGSLNY------AD........GI..NTYNTATF........GVNGANFMAKDI 62 ..GDGKGKTVIVGSRSN------RG........GW..NTYQSATV........AAMGDGFIARDI 63 ..GDGKGKTIISGSKNF------VD........GT..PTYETATF........AIQGKGFIMKDI 64 ..GDGQDSTIITGNLSA------SN........VR..RTFYTATFdns11mfeASNGKGFIGVDM 65 ..GDGIGKTIITGDKSK------GR........GF..STYKSATF........VAEGDGFVGRDI 66 ..GDGPTKTKFTGSLNY------AD........GI..NTYKTATF........GVNGANFMAKDI 67 ..GDGKDKTFVVGSRNF------MD........GT..PTFETATF........AVKGKGFIAKDI 68 ..GDGMGKTVITGSLNAG-----MP........GI..TTYNTATV........GVVGDGFMARDL 69 ..GDGERKTIITSGRSV------QH........GY..TTYNSATG........GFGGQRFVAKDM 70 ..GDGMDATIITGNLNV------VD........GA..TTFNSATV........AAVGDGFIAQDV 71 ..GEGMGETVITGSRSM------AA........GW..TTFRSATF........AVSGAGFIARDM 72 ..GDGPAKTKFTGSLNY------AD........GL..LPYNTATL........GVNGENFMAKDI 73 ..GDGRDLTVLSGDLNG------VD........GI..KTFDSATL........AVDESGFMAQDL 74 ..GDGIGKTVVKASRNV------VD........GW..TTFQSATV........AVVGDGFIAKGV 75 ..GDGQDLTIITSNLSA------SN........VR..RTFNTATVgkn27ifeASNGNGFIGVDM 76 ..GRGYQNTSIEWNDTA------KS........AG..NTADSFSF........VVFAANFTAYNI 77 ..GMGYSRTSIEWNNTT------AS........SN..GTFSSFSV........AVFGEKFTAYNI 78 ..GDGMDATIITGNLNV------ID........GS..TTFKSATV........AAVGDGFIAQDL 79 ..GDGMNATIITGSLNF------VD........GT..TTFRSATL........AAVGQGFILQDI 80 ..GTQASNTFLIW----------SD........GE..DILESPTL........TIFASDFVCRFL 81 ..GDGKDLTVITGSLNY------ID........GT..GTFQTATV........AAVGDGFIGQDI 82 ..GQPGAETVLTYHGTA-------A........QY..GTVESATL........IVWAEYFQAAHL 83 ..GQGFDITAIAWNDTA------YS........AN..GTFYCATV........QVFGSQFVAKNI 84 ..GDGMGKTVITGSISTG-----IT........RI..TTYNTATV........GILGDGFMASGL 85 ..GQTEDDTTYTGNLVNITHNIKLA........DVa.NDDETATV........RNHSPNSSIYNL 86 ..GGGIEKTIIAY----------GD........HQ..LTNTSATF........TSYPSNIIITGI 87 ..GQTEDTTTYTSNLVNITHAIALA........DVd.NDDETATL........RNYAEGSAIYNL 88 ..GQPNAMPVITYDGTA-------A........KY..GTVDSASL........IILSDYFMAVNI 89 ..GQPNAMPVITYDGTA-------A........KY..GTVDSASL........IILSDYFMAVNI 90 ..GKPGAETNLTYAGTA-------A........KY..GTVESATL........IVWATNFLAANL 91 ..GETTDTSGFASNTVTITQGKSQD........DVs.GNDLTATL........RAWTPNLKVYNI 92 ..GETKDTRSYSGNTVTITQRKSQN........DTp.SNDETATL........RAHTPNLKVYNI 93 ..GEGPTKTKITGNKSV------KD........GP..STFHTTTV........GVNGANFVAKNI 94 ..GNGKGKTVIESS---------QS........SV..DNVASATF........KVEANHFVAFGI 95 ..GQTENTDSYADNLVTITHAISYE........DAgeSDDLTATF........RNKAVGSQVYNL 96 ..GDGKDKTFVLGSRNF------MD........GT..PTFETATF........AVKGKGFIAKDI 97 ..GDGKYSTIIVGDDSV------AG........GS..TMPGSATI........TMTGDGFIARDI 98 ..-----------------------........--..--------........-------MAQDI 99 ..GDGRTRTIITGSRNV------VD........GS..TTFKSATV........------------ 100 slDANANNTVIVYNNANPTPASGAKtnp11snaTV..GTVRSATA........MVRASNFNARNL 101 ..-----------------------........--..--------........-IDGNWFMAQDL 102 ..GDGMNSTVITGSLNV------VD........GS..TTFRSATL........AAVGQGFILQDI 103 ..GTGEKPIDVKIGLSLDGGMSPADwrh30rsdSI..GVLCSAVF........WSQNNGLQLQNL 104 ..GTGEKPIDVKIGLSLDGGMSPADwrh30rsdSI..GVLCSAVF........WSQNNGLQLQNL 105 ..GAGDRPEQVVVSLALDSMMSPADyra30agaTI..NTTCSAVM........WSQSNDFQLKNL 106 ..-----------------------........--..--------........------------ 107 ..---------TYNRLT--------........--..--------........----------SL 108 ..GRPWKEYSRTVVMES-------Y........LG..GLINPAGW........AEWDGDFALKTL 109 ..ADGQDSTIITFNLSS------SN........SK..RTFNTATF........-----GKNLVDM 110 ..--------------------TAC........GG..QTPNSARF........QPVFPGTVSRPV 111 ..-----------------------........--..--------........------------ 112 ..-----------------------........--..--------........------------ 113 ..-----------------------........--..--------........------------ 114 ..GDGRTRTIITGSRNV------VD........GS..TTFHSATV........AAVREKFLTRDI 115 ..GDGKDATIITGSLNV------ID........GS..TTFRSATV........------------ 116 ..-----------------------........--..--------........------------ 117 ..-----------------------........--..--------........------------ 118 ..GDGRTRTIITGSRNV------VD........GS..TTFHSATV........AAV--------- 119 ..-----------------------........--..--------........------------ 110 120 130 140 150 160 | | | | | | 1 TIRNDFDFPANQAKSDSDSSKIKDTQAVALYVTKSGDRAYFKDVSLVGYQDTLYV........SG 2 CIQNTAG--------------PEKHQAVALRV--GGDMSVINRCPIDAYQDTLYA........HS 3 QFQNTAG--------------AAKHQAVALRV--GADQSVINRCKIDAFQDTLYT........HS 4 QFQNTAG--------------AAKHQAVALRV--GADQSVINRCKIDAFQDTLYT........HS 5 CIQNTAG--------------PAKDQAVALRV--GADMSVINRCRIDAYQDTLYA........HS 6 CIQNTAG--------------PAKDQAVALRV--GADMSVINRCRIDAYQDTLYA........HS 7 TFQNTAG--------------PSKHQAVALRV--GADLSAFYNCDMLAYQDTLYV........HS 8 TFQNTAG--------------PSKHQAVALRV--GADLSAFYNCDMLAYQDTLYV........HS 9 CIQNTAG--------------PAKDQAVALRV--GADMSVINRCRIDAYQDTLYA........HS 10 CIQNTAG--------------PAKHQAVALRV--GADKSVINRCRIDAYQDTLYA........HS 11 CIQNTAG--------------PAKHQAVALRV--GADKSVINRCRIDAYQDTLYA........HS 12 CIQNTAG--------------PAKHQAVALRV--GADKSVINRCRIDAYQDTLYA........HS 13 TFQNTAG--------------PSKHQAVALRV--GSDFSAFYQCDMFAYQDTLYV........HS 14 TFQNTAG--------------ASKHQAVALRV--GSDLSAFYKCDILAYQDTLYV........HS 15 CIQNTAG--------------PAKHQAVALRV--GADKSVINRCRIDAYQDTLYA........HS 16 TFQNTAG--------------PSKHQAVALRV--GSDFSAFYNCDMLAYQDTLYV........HS 17 TFQNTAG--------------ASKHQAVALCV--GSDLSAFYRCDMLAYQDTLYV........HS 18 WFQNTAG--------------AAKHQAVALRV--GADQSVINRCRIDAFQDTLYA........HS 19 TFENTAG--------------PEKHQAVALRS--DSDLSVFYRCNIRGYQDTLYT........HT 20 TFRNTAG--------------PEKHQAVAMRS--SADLSIFYSCSFEAYQDTLYT........HS 21 TFRNTAG--------------PEKHQAVALRS--GADFSIFYSCSFEAYQDTLYT........HS 22 TIRNDFDFPANQAKSDSDSSKIKDTQAVALYVTKSGDRAYFKDVSLVGYQDTLYV........SG 23 TIRNDFDFPANQAKSDSDSSKIKDTQAVALYVTKSGDRAYFKDVSLVGYQDTLYV........SG 24 GFRNTAG--------------PEKHQAVAIRV--QADRAIFLNCRFEGYQDTLYA........QT 25 TFRNTAG--------------ASNEQAVALRS--GSDLSVFYQCSFEAYQDTLYV........HS 26 -FQNTAG--------------AAKHQAVALRV--GADQSVINRCRIDAFQDTLYA........HS 27 CIQNTAG--------------PEKDQAVALRV--GADMSVINRCRIDAYQDTLYA........HS 28 TFQNTAG--------------PEKHQAVALRS--DSDLSVFFRCAMRGYQDTLYT........HT 29 GIENTAG--------------PEGGQAVALRV--SADYAVFHSCQIDGHQDTLYV........HS 30 TFQNTAG--------------PSKHQAVALRV--GSDFSAFYQCDMFAYQDTLYV........HS 31 GFQNTAG--------------PEKHQAVALRV--GADQSVINRCKIDAFQDTLYA........HS 32 TIRNTAG--------------PNNHQAVALRS--GSDLSVFYRCSFEGYQDTLYV........HS 33 GFQNTAG--------------PEKHQAVALRV--GADQSVINRCKIDAFQDTLYA........HS 34 TIRNTAG--------------PNNHQAVALRS--GSDLSVFYRCSFEGYQDTLYV........HS 35 SFVNYAG--------------PEKHQAVALRS--SSDLSAYYRCSFESYQDTIYV........HS 36 GFKNTAG--------------PMGHQAAAIRV--NGDRAVIFNCRFDGYQDTLYV........NN 37 TFRNTAG--------------PEKHQAVALRN--NAEGSSFYRCSFEGYQDTLYV........HS 38 GFKNTAG--------------PMGHQAVAIRV--NGDRAVIFNCRFDGYQDTLYV........NN 39 TFENWAG--------------PAKHQAVALRI--GADHAVIYRCNIIGYQDTLYV........HS 40 GFKNTAG--------------PMGHQAVAIRV--NGDRAVIFNCRFDGYQDTLYV........NN 41 GFENTAG--------------AARHQAVALRV--SADFAVFFNCHMNGYQDTLYV........HT 42 GFKNTAG--------------PMGHQAAAIRV--NGDRAVIFNCRFDGYQDTLYV........NN 43 GFINTAG--------------PSKHQAVALMV--SADLTAFYRCTMNAYQDTLYV........HA 44 GFENTAG--------------PEKEQAVALRV--SADKAIIYNCQIDGYQDTLYV........HT 45 GFKNTAG--------------PLGHQAVALRV--NGDRAVIFNCRFDGYQDTLYV........NN 46 GFRNTAG--------------PEGHQAVAIRV--QSDRSIFLNCRFEGYQDTLYA........YT 47 GFHNTAG--------------AERHQAVALRV--QGDLAAFYNCRFDAFQDTLYV........QP 48 GFQNTAG--------------PLGHQAVAFRV--NGDRAVIFNCRFDGYQDTLYV........NN 49 GFENTAG--------------AIKHQAVAVRV--QSDESIFFNCRFDGYQDTLYT........HS 50 TIRNTAG--------------PTKGQAVALRS--GGDLSVFYSCSFEAYQDTLYT........HS 51 TFENTAG--------------PHKHQAVALRV--SSDLSLFYRCSFKGYQDTLFT........HS 52 MITNTAG--------------PEKHQAVALRV--NADFVALYRCVIDGYQDTLYT........HS 53 SFVNSAG--------------PAKAQAVAFRS--GSDHSAFYRCEFDGYQDTLYV........HS 54 GFRNTAG--------------PEGHQAVAIRV--QSDRSVFLNCRFEGYQDTLYA........YT 55 TFENTAG--------------PEKHQAVALRS--SSDFSVFYACSFKGYQDTLYL........HS 56 TFVNNAG--------------PKSEQAVALRV--GADKSVVHRCSVEGYQDSLYT........HS 57 TFRNTAG--------------PQNRQAVALRV--DSDQSAFYRCSVEGYQDTLYA........HS 58 TFQNTAG--------------PEKHQAVAIRS--DTDLGVFYRCAMRGYQDTLYA........HS 59 GFQNTAG--------------PLGNQAVAFRV--NGDRAVIFNCRFDGYQDTLYV........NN 60 TFQNTAG--------------AAKHQAVALRV--GSDLSAFYRRDILAYQDSLYV........HS 61 GFENTAG--------------TGKHQAVALRV--TADQAIFYNCQMDGFQDTLYV........QS 62 TFVNSAG--------------PNSEQAVALRV--GSDRSVVYRCSIDGYQDSLYT........LS 63 GIINTAG--------------AAKHQAVAFRS--GSDFSVYYQCSFDGFQDTLYP........HS 64 CFRNTVG--------------PAKGPAVALRV--SGDMSVIYRCRVEGYQDALYP........HI 65 TIRNTAG--------------PENHQAVALRS--NSDMSVFYRCSIEGYQDTLYV........HS 66 GFENTAG--------------TSKFQAVALRV--TADQAIFHNCQMDGFQDTLFV........ES 67 GFVNNAG--------------ASKHQAVALRS--GSDRSVFFRCSFDGFQDTLYA........HS 68 TFQNTAG--------------PDAHQAVAFRS--DSDFSLIENCEFLGNQDTLYA........HG 69 TFINTAG--------------PLRGQAVAVRS--SSDLSVFYRVGIHGFQDTLYI........HS 70 QFQNTAG--------------AAKHQAVALRV--GAGQSVINRCKIDAFQDTLYT........HS 71 TIRNTAG--------------PAAHQAVALRV--DSDRSAFFRIAVEGHQDTLYA........HS 72 SIENTAG--------------PEKHQAVALRV--TADKAIFYNCQIDGYQATLFA........ES 73 CIRNTAG--------------PEKRQAVALRI--STDMTIIYRCRIDAYQDTLYA........YS 74 TFENSAG--------------PSKHQAVALRN--GADFSAFYQCSFVAYQDTLYV........HS 75 CFRNTAG--------------PAKGPAVALRV--SGDMSVIYRCRVEGYQDALYP........HS 76 SFKNNAPEPDPG---------EADAQAVALRI--EGDQAAFYGCGFYGAQDTLLD........DK 77 SFKNTAPAPNPG---------AVDAQAVALKV--VGDKAAFYGCGFYGNQDTLLD........QE 78 QFQNTAG--------------PQKHQAVALRV--GADQSVINRCKIDAFQDTLYT........HT 79 CIQNTAG--------------PEKHQAVALRI--GGDMSVINRCRIDAYQDTLYA........HS 80 TIQNKFG---------------TAGRAVALRV--AADKAAFYGCVITSYQDTLLD........DN 81 WFQNTAG--------------PQKHQAVALRV--GADQSVINRCRVDAYQDTLYA........HT 82 TIKNTAPMPKPG----------SQGQALAMRI--NADKAAFYSCRFHGFQDTLCD........DK 83 SFMNVAPIPKPG---------DVGAQAVAIRI--AGDESAFVGCGFFGAQDTLHD........DR 84 TIENTAG--------------PDAHQAVAFRS--DSDFSYIENCEFLGNQDTIYV........HS 85 NIINTCG--------------QVCHQALAVSP--YGNGQGYYGCQFTGYQDTLLA........QS 86 TFKNKYNI---------ASSSSPTKPAVAAMM--LGDKYAIIDSSFDGFQDTLYD........DY 87 NIANTCG--------------QACHQALAVSA--YASEQGYYACQFTGYQDTLLA........ET 88 VVKNTAPAPDGK---------TKGAQALSMRI--SGNFAAFYNCKFYGFQDTICD........DT 89 VVKNTAPAPDGK---------TKGAQALSMRI--SGNFAAFYNCKFYGFQDTICD........DT 90 NIINTSPMPKPG----------TQGQALAMRI--NGDKAAFYNCRFYGFQDTLCD........DR 91 NIVNTRG---------------EGSQALALSA--NADKQGYYGCQFKGYQDTILA........QT 92 NLVNTRG---------------QGSQALAVSA--WADKQGYYGCSFKGYQDTVLA........QL 93 GFENTAG--------------PEKEQAVALRV--SADKAIIYNCQIDGYQDTLYV........HT 94 SIRNDAPVGMAF---------TSENQSVAAFV--AADKVAFYHCAFYSLHNTLFD........NK 95 NIANTCG--------------QACHQALALSA--WADQQGYYGCNFTGYQDTLLA........QT 96 GFVNNAG--------------ASKHQAVALRS--GSDRSVFFRCSFDGFQDTLYA........HS 97 GFQNTAG--------------PQGEQALALNI--ASDHSVLYRCSIAGYQDTLYA........HA 98 WFQNTAG--------------PAKHQAVALRV--SADQTVINRCRIDAYQDTLYT........HT 99 -------------------------------------------------------........-- 100 TFKNSYV---------EGTFADNNQSAVALAV--RGDKAILENVSVIGNQDTLYLgatnnt..MV 101 WIQNTAG--------------PAKGQAVALRV--SGDAVVIYRCRIDAYQDTLYA........HS 102 CIQNTAG--------------PEKHQAVALRV--GADMSVINRCRIDAYQDTLYA........HS 103 TIENTLG----------DSVDAGNHPAVALRT--DGDQVQINNVNILGRQNTFFVtns12etnRQ 104 TIENTLG----------DSVDAGNHPAVALRT--DGDQVQINNVNILGRQNTFFVtns12etnRQ 105 TVVNALL----------DTVDSGTHQAVALRT--DGESGATGKCPPAQPSDTFFVnts12vtdHY 106 -------------------------------M--LGDRYVVTDSSFVGLQDTLFD........GK 107 TKANGMS--------------WDIKPAVAISV--YGDKSAFYNCDFLGLQDTVWD........NL 108 YYGEFMN----------------------GKV--GADMSVINRCRIDAYQDTLYA........HS 109 CFRNTTW--------------PVKGPVVTLRV--NGDMSIIYRCRVEEYQDALYP........HK 110 LSAQEAG--------------RFTHQAVALRT--DGESGATGKCPPAQPSDTFFVnts12vtdHY 111 -----------------------------------------------GRQDTFFVnts12vtdRY 112 -----------------------------------------------GFQDTLYP........HT 113 --------------------------------------------------DTLYA........HS 114 TFXNT--------------------------------------------------........-- 115 -------------------------------------------------------........-- 116 -------------------------------------------------------........-- 117 -------------------------------------------------------........-- 118 -------------------------------------------------------........-- 119 -------------------------------------------------------........-- 170 180 190 200 210 220 | | | | | | 1 GRSFFSDCRISGTVDFIFGD.GTALFNNCDLVSRYRADVK.SGNVSGYLTAPST..NINQKYGLV 2 QRQFYRDSYVSGTIDFIFGN.AAVVFQKCQLVARKP----.SKNQKNMVTAQGRt.DPNQATGTS 3 LRQFYRDCYITGTVDFIFGN.AAVVFQNSKIAARKP----.GSGQKNMVTAQGRe.DPNQNTGTS 4 LRQFYRDCYITGTVDFIFGN.AAVVFQNSKIAARKP----.GSGQKNMVTAQGRe.DPNQNTGTS 5 QRQFYRDSYVTGTVDFIFGN.AAVVFQKCQLVARKP----.GKYQQNMVTAQGRt.DPNQATGTS 6 QRQFYRDSYVTGTVDFIFGN.AAVVFQKCQLVARKP----.GKYQQNMVTAQGRt.DPNQATGTS 7 NRQFFVNCLIAGTVDFIFGN.AAAVLQNCDIHARKP----.NSGQKNMVTAQGRt.DPNQNTGIV 8 NRQFFVNCLIAGTVDFIFGN.AAAVLQNCDIHARKP----.NSGQKNMVTAQGRt.DPNQNTGIV 9 QRQFYRDSYVTGTVDFIFGN.AAVVFQKCQLVARKP----.GKYQQNMVTAQGTt.DPNQATGTS 10 QRQFYRDSYVTGTIDFIFGN.AAVVFQKCKLVARKP----.GKYQQNMVTAQGRt.DPNQATGTS 11 QRQFYRDSYVTGTIDFIFGN.AAVVFQKCQLVARKP----.GKYQQNMVTAQGRt.DPNQATGTS 12 QRQFYRDSYVTGTIDFIFGN.AAVVFQKCQLVARKP----.GKYQQNMVTAQGRt.DPNQATGTS 13 NRQFFVKCHITGTVDFIFGN.AAAVLQDCDINARRP----.NSGQKNMVTAQGRs.DPNQNTGIV 14 NRQFFVQCLVAGTVDFIFGN.GAAVLQDCDIHARRP----.GSGQKNMVTAQGRt.DPNQNTGIV 15 QRQFYQSSYVTGTIDFIFGN.AAVVFQKCQLVARKP----.GKYQQNMVTAQGRt.DPNQATGTS 16 NRQFFVKCLIAGTVDFIFGN.AAVVLQDCDIHARRP----.NSGQKNMVTAQGRt.DPNQNTGIV 17 NRQFFVQCLVAGTVDFIFGN.GAAVFQDCDIHARRP----.GSGQKNMVTAQGRt.DPNQNTGIV 18 NRQFYRDSVITGTIDFIFGN.AAVVFQKCNLVARKP----.MSNQKNMVTAQGRe.DPNQNTGTS 19 MRQFYRDCKISGTVDFIFGD.ATVVFQNCQILAKKG----.LPNQKNSITAQGRk.DPNEPTGIS 20 LRQFYRECDIYGTVDFIFGN.AAVVFQDCNLYPRQP----.MQNQFNAITAQGRt.DPNQNTGIS 21 LRQFYRECDVYGTVDFIFGN.AAVVFQNCNLYPRKP----.MPNQFNAITAQGRs.DPNQNTGTS 22 GRSFFSDCRISGTVDFIFGD.GTALFNNCDLVSRYRADVK.SGNVSGYLTAPST..NINQKYGLV 23 GRSFFSDCRISGTVDFIFGD.GTALFNNCDLVSRYRADVK.SGNVSGYLTAPST..NINQKYGLV 24 HRQFYRSCVITGTVDFIFGD.ATSVFQNCLITVRKP----.LENQQNIVTAQGRi.DGHETTGIV 25 NRQFYRDCDVYGTVDFIFGN.AAAVLQNCNIFARRP----.-RSKTNTITAQGRs.DPNQNTGII 26 NRQFYRDSVITGTIDFIFGN.AAVVFQKCNLVARKP----.MSNQKNMVTAQGRe.DPNQNTGTS 27 QRQFYRDSYVTGTVDFIFGN.AAVVFQKCQIVARKP----.NKRQKNMVTAQGRt.DPNQATGTS 28 MRQFYRECTITGTVDFIFGD.GTVVFQNCQILAKRG----.LPNQKNTITAQGRk.DVNQPSGFS 29 HRQFYRDCTVSGTVDFIFGD.AKCILQNCKIVVRKP----.NKGQTCMVTAQGRs.NVRESTGLV 30 NRQFFVKCHITGTVDFIFGN.AAAVLQDCDINARRP----.NSGQKNMVTAQGRs.DPNQNTGIV 31 NRQFYRDSFITGTVDFIFGN.AGVVFQKSKLVARKP----.MSNQKNMVTAQGRe.DPNQNTATS 32 QRQFYRECDIYGTVDFIFGN.AAVVLQNCNIFARKP----.-PNRTNTLTAQGRt.DPNQSTGII 33 NRQFYRDSFITGTVDFIFGN.AGVVFQKSKLVARKP----.MSNQKNMVTAQGRe.DPNQNTATS 34 QRQFYRECDIYGTVDFIFGN.AAVVLQNCNIFARXP----.-PNRTNTLTAQGRt.DPNQNTGII 35 HKQFYRECDIYGTVDFIFGD.ASVVFQNCSLYARRP----.NPNQKIIYTAQGRe.NSREPTGIS 36 GRQFYRNCVVSGTVDFIFGK.SATVIQNTLIVVRKG----.SKGQYNTVTADGNelGLGMKIGIV 37 LRQFYRECDIYGTVDFIFGN.AAAIFQNCNIYARKP----.MAKQKNAITAHGRl.DPNQNTGIS 38 GRQFYRNIVVSGTVDFIFGK.SATVIQNSLIVVRKG----.NKGQFNTVTADGNekGLAMKIGIV 39 NRQFFRECDIYGTVDFIFGN.AAVVLQNCSIYARKP----.MDFQKNTITAQNRk.DPNQNTGIS 40 GRQFYRNIVVSGTVDFIFGK.SATVIQNSLIVVRKG----.NKGQFNTVTADGNekGLAMKIGIV 41 HRQFYRNCRVSGTIDFVFGD.AKAVFQNCEFVIRRP----.MEHQQCIVTAQGRk.DRRETTGIV 42 GRQFYRNCVVSGTVDFIFGK.SATVIQNTLIVVRKG----.SKGQYNTVTADGNelGLGMKIGIV 43 QRQFYRECTIIGTVDFIFGN.SASVLQSCRILPRRP----.MKGQQNTITAQGRt.DPNMNTGIS 44 YRQFYRDCTITGTVDFIFGN.GEAVLQNCKVIVRKP----.AQNQSCMVTAQGRt.EPIQKGAIV 45 GRQFYRNIVVSGTVDFIFGK.SATVIQNSLILVRKG----.SPGQSNYVTADGNekGAAMKIGIV 46 HRQYYRSCVIVGTIDFIFGD.AAAIFQNCNIFIRKG----.LPGQKNTVTAQGRv.DKFQTTGFV 47 RRQFFRNCVVSGTIDFIFGN.SAAVFQNCLIITRRP----.MDNQQNSVTAHGPt.DPNMKSGLV 48 GRQFYRNIVVSGTVDFIFGK.SATVIQNSLILCRKG----.SPGQTNHVTADGNekGKAVKIGIV 49 HRQFFRDCTISGTIDFLFGD.AAAVFQNCTLLVRKP----.LPNQACPITAHGRk.DPRESTGFV 50 LRQFYRECDVYGTVDFIFGN.AAVVLQNCNLYPRQP----.RKGQSNEVTAQGRt.DPNQNTGTA 51 LRQFYRDCHIYGTIDFIFGD.AAAVFQNCDIFVRRP----.MDHQGNMITAQGRd.DPHTNSEFE 52 FRQFYRECDIYGTIDYIFGN.AAVVFQGCNIVSKLP----.MPGQFTVITAQSRd.TQDEDTGIS 53 AKQFYRECDIYGTIDFIFGN.AAVVFQNSSLYARKP----.NPGHKIAFTAQSRn.QSDQPTGIS 54 HRQYYRSCVIIGTVDFIFGD.AAAIFQNCDIFIRKG----.LPGQKNTVTAQGRv.DKFQTTGFV 55 SRQFLRNCNIYGTVDFIFGD.ATAILQNCNIYARKP----.MSGQKNTITAQSRk.EPDETTGFV 56 KRQFYRETDITGTVDFIFGN.SAVVFQSCNIAARKP----.LPGQRNFVTAQGRs.NPGQNTGIA 57 LRQFYRDCEIYGTIDFIFGN.GAAVLQNCKIYTRVP----.LPLQKVTITAQGRk.SPNQNTGFV 58 MRQFFRECIITGTVDFIFGD.ATAVFQSCQIKAKQG----.LPNQKNSITAQGRk.DPNEPTGFT 59 GRQFYRNIVVSGTVDFINGK.SATVIQNSLILCRKG----.SPGQTNHVTADGKqkGKAVKIGIV 60 NRQYFVQCLIAGTVDFIFGN.AAAVLQNCDIHARRP----.GSGQKNMVTAQGRt.DPNQNTGVV 61 QRQFYRDCSISGTIDFVFGE.RFGVFQNCKLVCRLP----.AKGQQCLVTAGGRe.KQNSASALV 62 KRQFYRETDITGTVDFIFGN.SAVVFQSCNLVSRKG----.-SSDQNYVTAQGRs.DPNQNTGIS 63 NRQFYRDCDVTGTIDFIFGS.AAVVFQGCKIMPRQP----.LSNQFNTITAQGKk.DPNQSSGMS 64 DRQFYRECFITGTVDFICGN.AAAVFQFCQIVARQP----.NMGQSNFITAQSRe.TKDDKSGFS 65 GRQFFRECDIYGTVDFIFGN.AAAVLQNCRIFARNP----.-PNGVNTITAQSRf.NPNQTTGIV 66 QRQFYRDCAISGTIDFVFGD.AFGVFQNCKLICRVP----.AKGQKCLVTAGGRd.KQNSASALV 67 NRQFYRDCDITGTIDFIFGN.AAVVFQSCKIMPRQP----.LPNQFNTITAQGKk.DPNQNTGII 68 LRQFYKNCRIQGNVDFIFGN.SAAVFQDCEILIAPRQINP.EKGEKNAVTAQGRi.DPSQSTGFV 69 QRQFFRECYISGTIDFIFGN.AAVVFQNCMILVRRP----.LHGQANIITAQGRg.DPFQNTGIT 70 LRQFYRDCYITGTVDFIFGN.AAVVFQNSKIAARKP----.GSGQKNMVTAQGRe.DPNQNTGTS 71 LRQFYRDCRVSGTVDFIFGN.GIAVIQRTTISTLPP---A.AGQNAGSVTAQGRr.DPNQNTGFA 72 QRQFYRDCSISGTIDMIYGD.AFAVFQNCKLIVRKP----.LEEQQCFVAADGRt.KSDSSSGFV 73 GRQFYRDCYITGTVDFIFGR.AAAVFQYCQIEARKP----.GIGQTNILTAQSRe.EDTATSGFS 74 LRQFYRECDVYGTVDFIFGN.AAAVLQNCNLYARKP----.NKNQRNLFTAQGRe.DPNQSTGIS 75 DRQFYRECFITGTVDFICGN.AVAVFQFCQIVARQP----.KMGQSNVITAQSRa.FKDIYSGFT 76 GRHFFKECFIQGSIDFIFGN.GRSLYQDCTINSIAK--GN.TSGVTGSITAQGRq.SEDEQSGFS 77 GRHFFKGCFIEGSIDFIFGN.GRSLYEDCTLHSIAK----.-ENTIGCITANGKd.TLKDRTGFV 78 LRQFYRDCYITGTVDFIFGN.AAVVFQNSKLAARKP----.MSGQKNMVTAQGRe.DPNQVTGTS 79 QRQFYRDSYVSGTIDFIFGN.AAVVFQKCQLVARKP----.SKYQKNMVTAQGRt.DPNQATGTS 80 GNHYFKNCYIEGATDFICGS.ASSLYERCHLHSLSP----.---NNGSITAQMRt.SATEKSGFT 81 NRQFYRDSFITGTVDFIFGN.AAVVFQKCYLVARKP----.MSNQKNMVTAQGRe.DPNQSTGTS 82 GNHFFKDCYIEGTYDFIFGR.GASLYLNTQLHA-------.VGDGLRVITAQGRq.SATEQNGYT 83 GRHYFKDCYIQGSIDFIFGN.AKSLYQDCRIISMANQLSPgSKAVNGAVTANGRs.SKDENSGFS 84 LRQLFKSCRIEGNVDFIFGN.AAAIFQDCTILVRPRQVKP.EKGETNAIAAHGRt.DPAQTTGFA 85 GNQVYAHNLIEGAVDFIFGQhARAWFQDCDIRVLKG----.--PSSGYITANGRs.SETDTSYYV 86 GRHYYKRCVISGGIDFIFGG.AQSIFEGCTLKLRVG-IYP.PNEVYGTITAQGRd.SPTDKGGFV 87 GYQVYAGTYIEGAVDFIFGQhARAWFHECDIRVLEG----.--PSSASITANGRs.SESDDSYYV 88 GNHFFKDCYVEGTFDFIFGS.GTSMYLGTQLHV-------.VGDGIRVIAAHAGk.SAEEKSGYS 89 GNHFFKDCYVEGTFDFIFGS.GTSMYLGTQLHV-------.VGDGIRVIAAHAGk.SAEEKSGYS 90 GNHFFKNCYIEGTYDFIFGR.GASLYLTTQLHA-------.VGDGLRVIAAHNRq.STTEQNGYS 91 GNQVYAKSYIEGATDFIFGQkATAWFDGVDIRV-------.LAASLGYITANGRd.SDSNPSYYV 92 GNQVYAKSYIEGATDFIFGQqARAWFDGCDIGV-------.LGAQVGWITASGRa.ADSNPSYYV 93 YRQFYRDCTITGTVDFIFGN.GEAVLQNCKVIVRKP----.AQNQSCMVTAQGRt.EPIQKGAIV 94 GRHYYHECYIQGSIDFIFGR.ATSIFNNCEIFVISD---K.RVKPYGSITAHHRe.SAEEKTGYV 95 GNQLYINSYIEGAVDFIFGQhARAWFQNVDIRVVEG----.--PTSASITANGRs.SETDTSYYV 96 NRQFYRDCDITGTIDFIFGN.AAVVFQSCKIMPRQP----.LPNQFNTITAQGKk.DPNQNTGII 97 LRQFYRECDIYGTVDFIFGN.AAAVFQNCYLVLRLP----.RKKGYNVILANGRs.DPGQNTGFS 98 LRQFYRDSYITGTVDFIFGN.SAVVFQNCDIVARNP----.GAGQKNMLTAQGRe.DQNQNTAIS 99 ------------------GQ.TAAVLQNCDIHARKP----.NSGQKNMVTAQGRa.DPNQNTGIV 100 IRAYFKNSFIQGDTDFIFGA.GTAVFHGCTIQYTAA--RL.GARATSYVFAPST..APDNPHGFL 101 YRQFYRDCFITGTVDFIFGH.ASAIFQNCRIEARKP----.MEGQSNVITAQQS..DKPGTSGFS 102 LRQFYRDCYVTGTVDFIFGN.AAVVLQKCQLVPRKP----.GKNQKNMVTAQGRt.DPNQATGTS 103 PRTLVTNSYIEGDVDIVSGR.GAVVFDNTEFRVVNS----.RTQQEAYVFAPAT..LSNIYYGFL 104 PRTLVTNSYIEGDVDIVSGR.GAVVFDNTEFRVVNS----.RTQQEAYVFAPAT..LSNIYYGFL 105 SRAYIKDSYIEGDVDYVFGR.ATAVFDRVRFHTVSS----.RGSKEAYVFAPDS..IPSVKYGFL 106 GRHYYKRCIISGGIDFIFGY.GQSLFKECTLNMTLG-IYA.PDNPYGTITAHQRp.SPSDEGGFV 107 GRHHFKNCYIEGAIDFIFGS.GQSVYE-------------.-------------..--------- 108 QRQFYRDDYVTGTVDFIFGG.AAVVKNKCQLVARKP----.GKYQQNMVTAQGRt.DPNQATGTS 109 NRQCYREYFLMDTVDFICGN.AAAVFQFCQIV--------.-------------..--------- 110 SRAYIKDSYIEGDVDYVFGR.ATAVFDRVRFHTVSS----.RGSKEAYVFAPDS..IPSVKYGFL 111 SRAYIKDSYIEGDVDYVFGR.ATAVFDRVHFHTVSS----.RGAKDIHVFAPDS..MPWAQYGFL 112 NRQFYRECRISGTVDFIFGD.ATVVFQNCQILVKKG----.LPNQKNTITAQGRk.DPAQPTGFS 113 NRQFYRECDITGTIDFIFGN.AAVVFQACKIQPRQP----.MSNQFNTITAQGKk.DPNQNTGIS 114 --------------------.-------------------.-------------..--------- 115 --------------------.-------------------.-------------..--------- 116 -----------GTXDFIFGN.AAVVFQDCNLYPRQP----.MQNQFNAITAQGRt.DPNQNTGIS 117 -----------GTXDFIFGN.SAVVFQNCDIVARNP----.GAGQKNMLTAQGRe.DQNQNTAIS 118 --------------------.-------------------.-------------..--------- 119 -----------GTXDFIFGA.GTVVFQGCSIRPRQP----.LPNQFNTITAEGTq.EANQNTGIS 230 240 250 260 270 | | | | | 1 ITNSRVIR.ESDSVPAK.......SYGLGRPWHPTTTFSDGRYADPNAIGQTVFLNTSMDNHIY. 2 IQFCDIIA.SPDLEPVVkef....KTYLGRPWKEYSR--------------TVVMQSYLGGLIDp 3 IQNCDIIP.SSDLAPVKgsv....KTYLGRPWKAYSR--------------TVFMQSNIGDHIDp 4 IQNCDIIP.SSDLAPVKgsv....KTYLGRPWKAYSR--------------TVFMQSNIGDHIDp 5 IQFCNIIA.SSDLEPVLkef....PTYLGRPWKEYSR--------------TVVMESYLGGLINp 6 IQFCDIIA.SSDLEPLLkef....PTYLGRPWKEYSR--------------TVVMESYLGGLINp 7 IQKSRIGA.TSDLKPVQgsf....PTYLGRPWKEYSR--------------TVIMQSSITDLIHp 8 IQKSRIGA.TSDLKPVQgsf....PTYLGRPWKEYSR--------------TVIMQSSITDLIHp 9 IQFCNIIA.SSDLEPVLkef....PTYLGRPWKEYSR--------------TVVMESYLGGLINp 10 IQFCNIIA.SSDLEPVLkef....PTYLGRPWKKYSR--------------TVVMESYLGGLINp 11 IQFCDIIA.SPDLKPVVkef....PTYLGRPWKKYSR--------------TVVMESYLGGLIDp 12 IQFCDIIA.SPDLKPVVkef....PTYLGRPWKKYSR--------------TVVMESYLGGLIDp 13 IQNCRIGG.TSDLLAVKgtf....PTYLGRPWKEYSR--------------TVIMQSDISDVIRp 14 IQKCRIGA.TSDLRPVQksf....PTYLGRPWKEYSR--------------TVIMQSSITDVIQp 15 IQFCDIIA.SPDLKPVVkef....PTYLGRPWKKYSR--------------TVVMESSLGGLIDp 16 IQKCRIGA.TSDLQSVKgsf....PTYLGRPWKEYSQ--------------TVIMQSAISDVIRp 17 IQKCRIGA.TSDLRPVQksf....PTYLGRPWKEYSR--------------TVIMQSSITDVIQp 18 IQQCNLTP.SSDLKAVVgsi....KTYLGRPWKKYSR--------------TVIMQSSIDSHIDp 19 IQFCNITA.DSDLEAASvnst...PTYLGRPWKLYSR--------------TVIMQSFLSNVIRp 20 IHNCTIKP.ADDLVSSNytv....KTYLGRPWKEYSR--------------TVFMQSYIDEVVEp 21 IQNCTIKP.ADDLVSSNytv....KTYLGRPWKEYSR--------------TVYMQSYIDGFVEp 22 ITNSRVIR.ESDSVPAK.......SYGLGRPWHPTTTFSDGRYADPNAIGQTVFLNTSMDNHIY. 23 ITNSRVIR.ESDSVPAK.......SYGLGRPWHPTTTFSDGRYADPNAIGQTVFLNTSMDNHIY. 24 LQSCRIEP.DKDLVPVKnki....RSYLGRPWKEFSR--------------TVIMDSTIGDFIHp 25 IHNSRVTA.ASDLRPVLgst....KTYLGRPWRQYSR--------------TVFMKTSLDSLIDp 26 -QQCNLTP.SSDLKAVVgsi....KTYLGRPWKKYSR--------------TVIMQSSIDSHIDp 27 IQFCDIIA.SPDLEPVMney....KTYLGRPWKKHSR--------------TVVMQSYLDGHIDp 28 IQFSNISA.DADLVPYLntt....RTYLGRPWKLYSR--------------TVFIRNNMSDVVRp 29 LHGCHITG.DPAYIPMKsvn....KAYLGRPWKEFSR--------------TIIMKTTIDDVIDp 30 IQNCRIGG.TSDLLAVKgtf....PTYLGRPWKEYSR--------------TVIMQSDISDVIRp 31 IQQCNVIP.SSDLKPVQgsi....KTYLGRPWKKYSR--------------TVVLQSVVDSHIDp 32 IHNCRVTA.ASDLKPVQssv....KTFLGRPWKQYSR--------------TVYIKTFLDSLINp 33 IQQCNVIP.SSDLKPVQgsi....KTYLGRPWKKYSR--------------TVVLQSVVDSHIDp 34 IHNCRVTA.ASDLKPVQssv....KTFLGRPWKQYSR--------------TVXIKTFLDSLINp 35 IISSRILA.APDLIPVQanf....KAYLGRPWQLYSR--------------TVIMKSFIDDLVDp 36 LQNCRIVP.DRKLTPERltv....ATYLGRPWKKFST--------------TVIMSTEMGDLIRp 37 IINCTIKA.APDLAAEPksa....MTFLGRPWKPYSR--------------TVFMQSYISDIVQp 38 LQNCRIVP.DKKLAAERliv....ESYLGRPWKKFST--------------TVIINSEIGDVIRp 39 IHASRVLA.ASDLQATNgst....QTYLGRPWKLFSR--------------TVYMMSYIGGHVHt 40 LQNCRIVP.DKKLAAERliv....ESYLGRPWKKFST--------------TVIINSEIGDVIRp 41 IHNSRITG.DASYLPVKakn....RAFLGRPWKEFSR--------------TIIMNTEIDDVIDp 42 LQNCRIVP.DRKLTPERltv....ATYLGRPWKKFST--------------TVIMSTEMGDLIRp 43 IHRCNISP.LGDLTDV-.......MTFLGRPWKNFST--------------TVIMDSYLHGFIDr 44 LQNCEIKP.DTDYFSLSpps....KTYLGRPWKEYSR--------------TIIMQSYIDKFIEp 45 LHNCRIIP.DKELEADKlti....KSYLGRPWKKFAT--------------TVIIGTEIGDLIKp 46 VHNCKIAA.NEDLKPVKeey....KSYLGRPWKNYSR--------------TIIMESKIENVIDp 47 IQNCRLVP.DQKLFPDRfki....PSYLGRPWKEFSR--------------LVIMESTIADFVKp 48 LHNCRIMA.DKELEADRltv....KSYLGRPWKPFAT--------------TAVIGTEIGDLIQp 49 FQGCTIAG.EPDYLAVKets....KAYLGRPWKEYSR--------------TIIMNTFIPDFVQp 50 IHGCTIRP.ADDLATSNytv....KTYLGRPWKEYSR--------------TVVMQTYIDGFLEp 51 AVKGRF--.--------.......KSYLGRPWKKYSR--------------TVFLKTDIDELIDp 52 MQNCSILA.SEDLFNSSnkv....KSYLGRPWREFSR--------------TVVMESYIDEFIDg 53 ILNCRILA.APDLIPVKenf....KAYLGRPWRKYSR--------------TVIIKSFIDDLIHp 54 IHNCTVAP.NEDLKPVKaqf....KSYLGRPWKPHSR--------------TVVMESTIEDVIDp 55 IQSSTVAT.AS------.......ETYLGRPWRSHSR--------------TVFMKCNLGALVSp 56 IQNCRITA.ES------.......MTYLGRPWKEYSR--------------TVVMQSFIGGSIHp 57 IQNSYVLA.TQ------.......PTYLGRPWKLYSR--------------TVYMNTYMSQLVQp 58 IQFSNIAA.DTDLLLNLntt....ATYLGRPWKLYSR--------------TVFMQNYMSDAINp 59 LHNCRIMA.DKELEADRltv....KSYLGRPWKPFAT--------------TAVIGTEIGDLIQp 60 IQNCRIGA.TSDLRPVQksf....PTYLGRPWKEYSR--------------TVIMQSSITDVINs 61 FQSSHFTG.EPALTSVTpk.....VSYLGRPWKQYSK--------------VVIMDSTIDAIFVp 62 IHNCRITG.ST------.......KTYLGRPWKQYSR--------------TVVMQSFIDGSIHp 63 IQRCTISA.NGNVIA--.......PTYLGRPWKEFST--------------TVIMETVIGAVVRp 64 IQNCNITA.SSDLDTATv......KTYLGRPWRIFST--------------VAVLQSFIGDLVDp 65 IHNSVVKG.APGVQLGGv......KTYLGRPWRSYAR--------------TVVIGTYLDTLIEp 66 FLSSHFTG.EPALTSVTpk.....LSYLGRPWKLYSK--------------VVIMDSTIDAMFAp 67 IQKSTITP.FGNNLTA-.......PTYLGRPWKDFST--------------TVIMQSDIGALLNp 68 FLNCLING.TEEYMKLFkanpkvhKNFLGRPWKDYSR--------------TVFIGCNLEALITp 69 IHSSRIIA.ASDLKPVIray....KTYLGRPWQAYSR--------------VTIMKTYIDNSISp 70 IQNCDIIP.SSDLAPVKgsv....KTYLGRPWKAYSR--------------TVFMQSNIGDHIDp 71 LHACIVEA.KY------.......PTYLGRPWKPFSR--------------VVVMESYLGAGVQp 72 FQSCHFTG.EPEVAKIDpk.....IAYLGRPWKSYSK--------------VVIMDSNIDDIFDp 73 FQKCNISA.SSDLTPIKgtv....KTFLGRPWRAFSR--------------VVFMESFIDDVIDr 74 IINCKVAA.AADLIPVKsef....RNYLGRPWKMYSR--------------TVFLNSLMEDLIEp 75 IQKCNITA.SSDLDTTTv......KTYLGRPWRIFST--------------VAVMQSFIGDLVDp 76 FVNCKIDG.SG------.......EILLGRAWGAYAT--------------VVFSNTYMSGIITp 77 FVNCKITG.SA------.......RVWLGRAWRPYAR--------------VIFSKTYMSRVVSl 78 IQNCDIIP.SSDLAPVKgsv....KTYLGRPW--------------------------------. 79 IQFCDIIA.SPDLEPVVnef....KTYLGRPW--------------------------------. 80 FLGCKLTG.SG------.......STFLGRPWGAYSR--------------VVFAYSFFSNVVAp 81 IQQCNITP.SLDLKPVAgsi....KTYLGRPW--------------------------------. 82 FVHCKVTG.TGT-----.......GIYLGRSWMSHPK--------------VVYAFTEMTSVVNp 83 FVNCTIGG.TG------.......HVWLGRAWRPYSR--------------VVFVSTTMTDVIAp 84 FLGCLING.TDDYMKLYhskpskhKNYLGRPWKMYSR--------------TVYINCTMESLIAp 85 IHKSSVAAaDGNDVPSG.......TYYLGRPWSQYAR--------------VLYQETSMTDVINs 86 FKDCTVMG.SG------.......KALLGRAWKSYSR--------------VIFYRSMFSDNILp 87 IHKSTVAAaDGNDVSSG.......TYYLGRPWSQYAR--------------VCFQKTSMTDVINh 88 FVHCKVTG.TGG-----.......GIYLGRAWMSHPK--------------VVYAYTEMTSVVNp 89 FVHCKVTG.TGG-----.......GIYLGRAWMSHPK--------------VVYAYTEMTSVVNp 90 FVHCKVTG.VGT-----.......GIYLGRAWMSHPK--------------VVYSYTEMSSVVNp 91 INKSKVSAaSGNTVKAG.......AFYLGRPWRNYAR--------------VVFQNTAPSNVVNa 92 FNKSKVSPaVGATVSSG.......VYYLGRPWGNYAR--------------VVFQHTDLSNVINp 93 LQNCEIKP.DTDYFSLSpps....KTYLGRPW--------------------------------. 94 FIRGKVYG.ID------.......EVYLGRAKGPYSR--------------VIFAKTYLSKTVVp 95 INKSTVAAkEGDDVAEG.......TYYLGRPWSEYAR--------------VVFQQTSMTNVINs 96 IQKSTITP.FGNNLTA-.......PTYLGRPW--------------------------------. 97 VHNCRIVP.SSEFSPVKhky....ESYLGRPW--------------------------------. 98 IQKCKITA.SSDLAPVKgsv....KTFLGRPWKLYSR--------------TVIMQSFIDNHIDp 99 IQKSRIGA.TSDLKPVQgsf....PTYLGRPWKEYSR--------------TVIMQSSITDVIHp 100 AINSTFNA.TGNASNN-.......STHLGRAWDQGVSGTSAYINGSSPNGQVVIRDSSLGAHIR. 101 IQNCSITA.SSDLVPVKrmv....KTFLGRPWGDFST--------------VVFMESYLDDMIDp 102 IQFCNIIA.SPDLEPVKney....KTYLGRPW--------------------------------. 103 AVNSRFNA.FGD----G.......VAQLGRSLDVDAN----------TNGQVVIRDSAINEGFN. 104 AVNSRFNA.FGD----G.......VAQLGRSLDVDAN----------TNGQVVIRDSAINEGFN. 105 VINSQLTG.DNGYRGAQ.......KAKLGRAWDQGAK-QTGYLPGKTANGQLVIRDSTIDSSYD. 106 FSDCTVTG.VG------.......KTLLGRAWGSNAR--------------VIFDRSRLSDVVLp 107 --------.----VWST.......SVYLGRAYGPFSR--------------VIFIQTDLSSVVHp 108 IQFCNIIA.SGDLERPVmivgd..--------GMYATTITGSL--NVVEGSTTFRSATLAAVGQ. 109 --------.--------.......----------------------------------------. 110 VINSQLTG.DNGYRGAQ.......KAKLGRAWD-------------------------------. 111 AVSCRFTG.DEGFSGGR.......KAKLGRAWDQGAR-QTGYQPNKTANGQLVIRDSTIDASYD. 112 IQFSNISA.DSDLLASVnst....LSHLGRPW--------------------------------. 113 IQKCSISA.LN------.......----------------------------------------. 114 --------.--------.......----------------------------------------. 115 --------.--------.......----------------------------------------. 116 IYNCTIKP.ADDLVSSNytv....KTYXGRPWKEY-----------------------------. 117 IQKCKITA.SSDLAPVKgsv....KTYXGRPWKEY-----------------------------. 118 --------.--------.......----------------------------------------. 119 IHQCTISP.NGNVTA--.......TTYXGRPWKEY-----------------------------. 280 290 300 310 320 | | | | | 1 .GWDKM........SGKDKNGNTI..WFNPEDSRF...FEYKSYGAGAA..VSKDRRQLTDAQAA 2 aGWAEW........SGE-------..-FALKTLYY...GEYMNNGPGAG..TSKRVKWPGYHVIT 3 eGWSVW........DGD-------..-FALKTLYY...GEYMNKGPGAG..TSKRVKWPGYHILS 4 eGWSVW........DGD-------..-FALKTLYY...GEYMNKGPGAG..TSKRVKWPGYHILS 5 aGWAEW........DGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHVIT 6 aGWAEW........DGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHVIT 7 aGWHEW........DGN-------..-FALNTLFY...GEHQNSGAGAG..TSGRVKWKGFRVIT 8 aGWHEW........DGN-------..-FALNTLFY...GEHQNSGAGAG..TSGRVKWKGFRVIT 9 aGWAEW........DGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHVIT 10 aGWAEW........DGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHCIT 11 sGWAEW........HGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHVIT 12 sGWAEW........HGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHCIT 13 eGWHEW........SGS-------..-FALDTLTY...REYLNRGGGAG..TANRVKWKGYKVIT 14 aGWHEW........NGN-------..-FALNTLFY...GEYANTGAGAA..TSGRVKWKGHKVIT 15 sGWAEW........HGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHVIT 16 eGWSEW........TGT-------..-FALNTLTY...REYSNTGAGAG..TANRVKWRGFKVIT 17 aGWHEW........NGN-------..-FALDTLFY...GEYANTGAGAP..TSGRVKWKGHKVIT 18 tGWAEW........DAQSK-----..-DFLQTLYY...GEYMNSGAGAG..TSKRVNWPGYHIIT 19 eGWLEW........NGD-------..-FALNSLFY...GEYMNYGPGAG..LGSRVKWPGYQVFN 20 vGWREW........NGD-------..-FALSTLYY...AEYNNTGSGSS..TTDRVVWPGYHVIN 21 vGWREW........NGD-------..-FALSTLYY...AEYNNTGPGSN..TTNRVTWPGYHVIN 22 .GWDKM........SGKDKNGNTI..WFNPEDSRF...FEYKSYGAGAA..VSKDRRQLTDAQAA 23 .GWDKM........SGKDKNGNTI..WFNPEDSRF...FEYKSYGAGAT..VSKDRRQLTDAQAA 24 gGWLPW........QGD-------..-FGLKTLYY...AEYSNKGGGAQ..TNARIKWPGYHIIK 25 rGWLEW........DGN-------..-FALKTLFY...AEFQNTGPGAS..TSGRVTWPGFRVL- 26 tGWAEW........DAQSK-----..-DFLQTLYY...GEYMNSGAGAG..TSKRVNWPGYHIIT 27 sGWFEW........RGD-------..-FALKTLYY...GEFMNNGPGAG..TSKRVKWPGYHVIT 28 eGWLEW........NAD-------..-FALDTLFY...GEFMNYGPGSG..LSSRVKWPGYHVFN 29 aGWLPW........SGD-------..-FALKTLYY...AEHMNTGPGSN..QAQRVKWPGIKKLT 30 eGWHEW........SGS-------..-FALDTLTY...REYLNRGGGAG..TANRVKWKGYKVIT 31 aGWAEW........DAASK-----..-DFLQTLYY...GEYLNSGAGAG..TSKRVTWPGYHIIK 32 aGWMEW........SGD-------..-FALNTLYY...AEYMNTGPGSS..TANRVKWRGYHVLT 33 aGWAEW........DAASK-----..-DFLQTLYY...GEYLNSGAGAG..TSKRVTWPGYHIIK 34 aGWMEW........SGD-------..-FALNTLYY...AEYMNTGPGSS..TANRVKWRGYHVLT 35 aGWLKW........KDD-------..-FALETLYY...GEYMNEGPGSN..MTNRVQWPGFKRIE 36 eGWKIW........DGE-------..-SFHKSCRY...VEYNNRGPGAF..ANRRVNWAKVARSA 37 vGWLEW........NGT-------..-IGLDTIYY...GEYSNFGPGAN..TNQRVQWLGYNLLN 38 eGWKIW........DGE-------..-SFHKSCRY...VEYNNRGPGAI..TNRRVNWVKIARSA 39 rGWLEW........NTT-------..-FALDTLYY...GEYLNSGPGSG..LGQRVSWPGYRVIN 40 eGWKIW........DGE-------..-SFHKSCRY...VEYNNRGPGAI..TNRRVNWVKIARSA 41 eGWLKW........NET-------..-FALNTLFY...TEYRNRGRGSG..QGRRVRWRGIKRIS 42 eGWKIW........DGE-------..-SFHKSCRY...VEYNNRGPGAF..ANRRVNWAKVARSA 43 kGWLPW........TGD-------..-SAPDTIFY...GEYKNTGPGAS..TKNRVKWKGLRFLS 44 eGWAPW........NITN------..-FGRDTSYY...AEYQNRGPGAA..LDKRITWKGF---- 45 eGWTEW........QGE-------..-QNHKTAKY...IEFNNRGPGAA..TTQRPPWVKVAKSA 46 vGWLRW........QETD------..-FAIDTLYY...AEYNNKGSSGD..TTSRVKWPGFKVIN 47 eGYMPW........NGD-------..-FALKTLYY...AEYNNRGPGAG..TSKRVNWPGFHVIG 48 tGWNEW........QGE-------..-KFHLTATY...VEFNNRGPGAN..TAARVPWAKMAKSA 49 qGWQPW........LGD-------..-FGLKTLFY...SEVQNTGPGSA..LANRVTWAGIKTLS 50 sGWNAW........SGD-------..-FALSTLYY...AEYNNTGPGSD..TTNRVTWPGYHVIN 51 rGWREW........SGS-------..-YALSTLYY...GEFMNTGAGAG..TGRRVNWPGFHVLR 52 sGWSKW........NGG-------..-EALDTLYY...GEYNNNGPGSE..TVKRVNWPGFHIMG 53 aGWLEG........KKD-------..-FALETLYY...GEYMNEGPGAN..MAKRVTWPGFRRIE 54 vGWLRW........QETD------..-FAIDTLSY...AEYKNDGPSGA..TAARVKWPGFRVLN 55 aGWLPW........SGS-------..-FALSTLYY...GEYGNTGAGAS..VSGRVKWPGYHVIK 56 sGWSPW........SGG-------..-FGLKSLFY...GEYGNSGPGSS..VSGRVKWSGCHPS- 57 rGWLEW........FGN-------..-FALDTLWY...GEYNNIGPGWR..SSGRVKWPGYHIMD 58 vGWLEW........NGN-------..-FALDTLYY...GEYMNSGPGAS..LDRRVKWPGYHVLN 59 tGWNEW........QGE-------..-KFHLTATY...VEFNNRGPGAN..PAARVPWAKMAKSA 60 aGWHEW........NGN-------..-FALNTLFY...GEYQNTGAGAG..TSGRVKWRGFKVIT 61 eGYMPW........MGS-------..-AFKETCTY...YEYNNKGPGAD..TNLRVKWHGVKVLT 62 sGWSPW........SSN-------..-FALKTLYY...GEFGNSGPGSS..VSGRVSWAGYHPA- 63 sGWMSW........VSGV------..-DPPASIVY...GEYKNTGPGSD..VTQRVKWAGYKP-- 64 aGWTPW........EGE-------..-TGLSTLHY...REYQNRGPGAV..TSRRVKWSGFKVMK 65 nGWIDW........DNV-------..-TALSTLYY...GEYQNSGPGSG..TENRVDWAGFHVIS 66 eGYMPM........VGG-------..-AFKDTCTF...YEYNNKGPGAD..TNLRVKWHGVKVLT 67 vGWMSW........VPNV------..-EPPTTIFY...AEYQNSGPGAD..VSQRVKWAGYK--- 68 dGWLPW........SGD-------..-FALKTLYY...GESKNTGPGSD..RSQRVSWSSQIPDE 69 lGWSPW........LRGSN-----..-FALNTVFY...GEYKNFGPGSS..TRWRVRWKGFHAIT 70 eGWSVW........DGD-------..-FALKTLYY...GEYMNKGPGAG..TSKRVKWPGYHILS 71 rGWLEW........DGDG------..-GELATLFY...GEYRNYGPGAN..IGGRVRWPGYHVIM 72 eGYMPW........MGS-------..-AFKDTCTF...YEYNNKGPGAD..TSKRVKWPGVKSIS 73 .-----........----------..---------...---------AD..TSKRVGWKGYHTI- 74 aGWLEW........NGT-------..-FALDTLYY...GEYNNRGPGAN..TSGRVTWPGYRVIT 75 aGWTPW........EGE-------..-TGLSTLHY...REYQNRGPGAV..TSRRVKWSGFKVMK 76 eGWNNW........GDS-------..-TKEKTVTF...GEHKCYGPGAD..YKERVLFGKQLTDS 77 dGWNDM........GDP-------..-KTQRTVYY...GEHRCYGPGAN..HSKRVTYAKLLSDV 78 .-----........----------..---------...-----------..-------------- 79 .-----........----------..---------...-----------..-------------- 80 qGWNQW........GDS-------..-TKENTVYY...GEYKCYGPGAD..REQRVEWSKQLSDE 81 .-----........----------..---------...-----------..-------------- 82 sGWREN........LNR-------..-GYDKTVFY...GEYKCFGPGSH..LEKRVPYTQDIDKN 83 eGWNNF........NDP-------..-SRDATIFY...GEYNCSGPGAD..MSKRAPYVQKLNET 84 eGWLPW........SGD-------..-FALSTLYY...GEFGNSGPGAN..VSSRVPWSRLVPEE 85 aGWSVW........STTQ------..-ANTENVTF...AEYGNTGAGAE..--GTRASFSEKLSE 86 iGWDAW........KAK-------..-GQEGHITF...VEFGCTGVGAD..TSKRVPWLTKASEK 87 lGWTEW........STST------..-PNTENVTF...VEYGNTGTGAE..--GPRANFSSELTE 88 tGWQEN........KTP-------..-AHDKTVFY...GEYKCSGPGSH..KAKRVPFTQDIDDK 89 tGWQEN........KTP-------..-AHDKTVFY...GEYKCSGPGSH..KAKRVPFTQDIDDK 90 sGWQEN........RVR-------..-AHDKTVFY...GEYMCTGPGSH..KAKRVAHTQDIDNK 91 kGWTQW........GSSD------..-PRTDKVTF...GEYGNTGDGAS..--GTRATFAKKLSS 92 qGWAAW........NTGD------..-ARTDHVLF...GEYQNTGAGAS..---GKRSFGQTLKA 93 .-----........----------..---------...-----------..-------------- 94 dGWTNW........SYH-------..-GSTQNLYH...GEYKCHGPGAE..RQKRSDWAKDLTKQ 95 lGWTEW........STST------..-PNTEYVTF...GEYANTGAGSE..--GTRASFAEKLDA 96 .-----........----------..---------...-----------..-------------- 97 .-----........----------..---------...-----------..-------------- 98 aGWFPW........DGE-------..-FALSTLYY...GEYANTGPGAD..TSKRVNWKGFKVIK 99 aGWHEW........DGN-------..-FALNTLFY...GEHQNAGAGAG..TSGRVKWKGFRVIT 100 .LADPW........GPSTAGRPYCssKCAYSANRF...FEYNNTGAGS-..-------------- 101 mGWTPW........NSSTT-----..-GRLSTLYY...GEYKNKGPRAN..TSQRV--------- 102 .-----........----------..---------...-----------..-------------- 103 .TAKPWada13agnTGSVDDNDEI..QRNLNDTNYnrmWEYNNRGVGSK..-------------- 104 .TAKPWada13agnTGSVDDNDEI..QRNLNDTNYnrmWEYNNRGVGSK..-------------- 105 .LANPW........GAAATTDRPF..KGNI-----...-----------..-------------- 106 iGWDAW........RAK-------..-GNERDLTF...VEAGCTGAGAD..TSQRVPWLKKLSLS 107 eGWYSW........HYG-------..-GYEMSFTY...AEVECKGAGSD..MSRRVPWIDKLHSF 108 .GTLLQ........DICIQ-----..---------...---NTAGPARDqaVALRVKWPGYHVIT 109 .-----........----------..---------...-----------..-------------- 110 .-----........----------..---------...-----------..-------------- 111 .REQPW........GVAATTARPF..AGNVD----...-----------..-------------- 112 .-----........----------..---------...-----------..-------------- 113 .-----........----------..---------...-----------..-------------- 114 .-----........----------..---------...-----------..-------------- 115 .-----........----------..---------...-----------..-------------- 116 .-----........----------..---------...-----------..-------------- 117 .-----........----------..---------...-----------..-------------- 118 .-----........----------..---------...-----------..-------------- 119 .-----........----------..---------...-----------..-------------- 330 340 | | 1 EYTQSKVLGDWTPTLP 2 D--------------- 3 AAE------------- 4 AAE------------- 5 D--------------- 6 D--------------- 7 SA-------------- 8 SA-------------- 9 D--------------- 10 D--------------- 11 D--------------- 12 D--------------- 13 ---------------- 14 S--------------- 15 D--------------- 16 ---------------- 17 S--------------- 18 ---------------- 19 EST------------- 20 S--------------- 21 S--------------- 22 EYTQSKVLGDWTPTLP 23 EYTQSKVLGDWTPTLP 24 KEEA------------ 25 ---------------- 26 S--------------- 27 D--------------- 28 N--------------- 29 PQDALLYTGD------ 30 ---------------- 31 ---------------- 32 SP-------------- 33 ---------------- 34 SP-------------- 35 TV-------------- 36 AEVNGFTAANWLGP-- 37 ---------------- 38 AEVNDFTVANWLGP-- 39 ---------------- 40 AEVNDFTVANWLGP-- 41 DRA------------- 42 AEVNGFTAANWLGP-- 43 ---------------- 44 ---------------- 45 AEVETYTVANWVG--- 46 KEE------------- 47 ---------------- 48 AEVERFTVANWLT--- 49 EEDIL----------- 50 AT-------------- 51 ---------------- 52 YE-------------- 53 NQ-------------- 54 KEEA------------ 55 TV-------------- 56 ---------------- 57 KRT------------- 58 ---------------- 59 AEVERFTVANWLT--- 60 S--------------- 61 S--------------- 62 ---------------- 63 ---------------- 64 DP-------------- 65 D--------------- 66 S--------------- 67 ---------------- 68 HV-------------- 69 S--------------- 70 AAE------------- 71 DA-------------- 72 STEAAAF--------- 73 ---------------- 74 N--------------- 75 DP-------------- 76 EASS------------ 77 EAAPF----------- 78 ---------------- 79 ---------------- 80 EATVF----------- 81 ---------------- 82 EVTPFLTLG------- 83 Q--------------- 84 HVS------------- 85 PVAISTILGSDWAQW- 86 DVLQFT---------- 87 PITISWLLGSDWEDW- 88 EANCFLSLG------- 89 EANRFLSLG------- 90 EASQFLTLG------- 91 AVSISTVLGSSYKNW- 92 ALSITDILGSNYKDW- 93 ---------------- 94 EVESFLS--------- 95 KLTITDILGSDYTSW- 96 ---------------- 97 ---------------- 98 D--------------- 99 SA-------------- 100 ---------------- 101 ---------------- 102 ---------------- 103 ---------------- 104 ---------------- 105 ---------------- 106 EVDGF----------- 107 YTKQQFSISNF----- 108 ---------------- 109 ---------------- 110 ---------------- 111 ---------------- 112 ---------------- 113 ---------------- 114 ---------------- 115 ---------------- 116 ---------------- 117 ---------------- 118 ---------------- 119 ----------------