28 August 1998 Christian ==> t85-2nd-fssp-vit.rdb <== HMM TARGET BUILDSCRIPT VITERBI SW_SCORE SCORE 8S 8S 15S 1N 1N 10N 2trcP t85-2nd varh50 1 2 -5.550 1dmr t85-2nd varh50 1 2 -5.310 1avc t85-2nd varh50 1 2 -4.900 1lefA t85-2nd varh50 1 2 -4.320 1rec t85-2nd varh50 1 2 -4.220 1avqA t85-2nd varh50 1 2 -4.180 1tf4A t85-2nd varh50 1 2 -3.960 1djxB t85-2nd varh50 1 2 -3.690 1dik t85-2nd varh50 1 2 -3.530 1occM t85-2nd varh50 1 2 -3.510 1pysA t85-2nd varh50 1 2 -3.360 1zwb t85-2nd varh50 1 2 -3.280 1avc is a phospholipid-binding protein, which is exactly the type of protein I was hoping for. Other structures in the 1avc FSSP family that show up in the rdb files: Z %IDE 1ain t85-2nd-sum98.rdb -3.410 41.7 46 1axn t85-2nd-sum98.rdb 0.280 40.4 52 1hvd t85-2nd-sum98.rdb 0.280 40.1 57 1occE t85-2nd-sum98.rd -0.570 4.5 10 3bct t85-2nd-sum98.rdb -0.080 4.3 3 1abv t85-2nd-sum98.rdb 0.390 4.0 4 Here are the non-self scores for 1avc 1avc/1avc-t85-2nd-fssp-global.pw.dist:t85-2nd 72 65.06 1000000.00 1avc/1avc-t85-2nd-global.pw.dist:t85-2nd 72 40.51 1000000.00 1avc/1avc-t85-2nd-vit.pw.dist:t85-2nd 72 -1.65 -0.36 1avc/t85-2nd-1avc-global.pw.dist:1avc 642 -7.59 -4.37 1avc/t85-2nd-1avc-vit.pw.dist:1avc 642 -4.85 -3.47 t85-2nd-1avc.cbarrett1.a2m This alignment is to a nice looking separable piece of 1avc that has 17 identities out of 65 aligned positions (71 if you count the one 6-residue deletion).