LOCUS       118458       1752 aa                              15-JUL-1998
DEFINITION  DESMOPLAKIN I AND II (DPI AND DPII).
ACCESSION   118458
PID         g118458
DBSOURCE    SWISS-PROT: locus DESP_HUMAN, accession P15924
            class: standard.
            created: Apr 1, 1990.
            sequence updated: Apr 1, 1990.
            annotation updated: Jul 15, 1998.
            xrefs: gi: 181607, gi: 181608, gi: 105831
            xrefs (non-sequence databases): MIM 125647
KEYWORDS    REPEAT; COILED COIL; PHOSPHORYLATION; CYTOSKELETON; STRUCTURAL
            PROTEIN; ALTERNATIVE SPLICING.
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
            Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1752)
  AUTHORS   Green,K.J., Parry,D.A., Steinert,P.M., Virata,M.L., Wagner,R.M.,
            Angst,B.D. and Nilles,L.A.
  TITLE     Structure of the human desmoplakins. Implications for function in
            the desmosomal plaque
  JOURNAL   J. Biol. Chem. 265 (5), 2603-2612 (1990)
  MEDLINE   90153880
  REMARK    SEQUENCE FROM N.A.
            Erratum:[[published erratum appears in J Biol Chem 1990 Jul
            5;265(19):11406-7]]
COMMENT     [FUNCTION] MAY PLAY A ROLE IN ATTACHING INTERMEDIATE FILAMENTS TO
            THE CELL SURFACE.
            [SUBUNIT] DP IS A TWO-STRANDED COILED COIL STRUCTURE.
            [SUBCELLULAR LOCATION] INNERMOST PORTION OF THE DESMOSOMAL PLAQUE.
            [TISSUE SPECIFICITY] DPI IS APPARENTLY AN OBLIGATE CONSTITUENT OF
            ALL DESMOSOMES; DPII RESIDE PREDOMINANTLY IN TISSUES AND CELLS OF
            STRATIFIED ORIGIN.
            DESMOPLAKINS I AND II ARE THE MAJOR HIGH MOLECULAR WEIGHT DESMOSOME
            PROTEINS.
            [ALTERNATIVE PRODUCTS] DPI AND DPII DERIVE FROM THE SAME GENE BY
            ALTERNATIVE SPLICING.
FEATURES             Location/Qualifiers
     source          1..1752
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     1..1752
     Protein         <1..1752
                     /product="DESMOPLAKIN I AND II"
     Region          42..900
                     /note="ROD (HEPTAD REPEAT PATTERN)."
                     /region_name="Domain"
     Region          42..197
                     /note="1."
                     /region_name="Repetitive region"
     Region          42..384
                     /note="2.5 X 156 AA APPROXIMATE TANDEM REPEATS."
                     /region_name="Domain"
     Region          76..675
                     /note="MISSING (IN DPII)."
                     /region_name="Splicing variant"
     Region          198..353
                     /note="2."
                     /region_name="Repetitive region"
     Region          262..826
                     /note="COILED COIL."
                     /region_name="Domain"
     Region          354..384
                     /note="3 (INCOMPLETE)."
                     /region_name="Repetitive region"
     Region          907..1064
                     /note="4.5 X 38 AA TANDEM REPEATS, A DOMAIN."
                     /region_name="Domain"
     Region          1150..1325
                     /note="TO THE HUMAN BP ANTIGEN (AA 427-600)."
                     /region_name="Similarity"
     Region          1150..1325
                     /note="4.5 X 38 AA TANDEM REPEATS, B DOMAIN."
                     /region_name="Domain"
     Region          1349..1379
                     /note="SINGLE NEAR COMPLETE REPEAT."
                     /region_name="Repetitive region"
     Region          1509..1684
                     /note="4.5 X 38 AA TANDEM REPEATS, C DOMAIN."
                     /region_name="Domain"
     Region          1705..1728
                     /note="6 X 4 AA TANDEM REPEATS OF G-S-R-[SR]."
                     /region_name="Domain"
     Site            1730
                     /note="(BY CAPK)."
                     /site_type="phosphorylation"
ORIGIN      
        1 rekrrrksve drfdqqkndy dqlqkarqce kenlgwqkle sekaikekey eierlrvllq
       61 eegtrkreye nelakvrnhy neemsnlrnk yeteinitkt tikeismqke ddsknlrnql
      121 drlsrenrdl kdeivrlnds ilqateqrrr aeenalqqka cgseimqkkq hleielkqvm
      181 qqrsednarh kqsleeaakt iqdknkeier lkaefqeeak rrweyenels kvrnnydeei
      241 islknqfete initkttihq ltmqkeedts gyraqidnlt renrslseei krlkntltqt
      301 tenlrrveed iqqqkatgse vsqrkqqlev elrqvtqmrt eesvrykqsl ddaaktiqdk
      361 nkeierlkql idketndrkc ledenarlqr vqydlqkans satetinklk vqeqeltrlr
      421 idyervsqer tvkdqditrf qnslkelqlq kqkveeelnr lkrtasedsc krkkleeele
      481 gmrrslkeqa ikitnltqql eqasivkkrs eddlrqqrdv ldghlrekqr tqeelrrlss
      541 evealrrqll qeqesvkqah lrnehfqkai edksrslnes kieierlqsl tenltkehlm
      601 leeelrnlrl eyddlrrgrs eadsdknati lelrsqlqis nnrtlelqgl indlqreren
      661 lrqeiekfqk qaleasnriq esknqctqvv qeresllvki kvleqdkarl qrledelnra
      721 kstleaetrv kqrlecekqq iqndlnqwkt qysrkeeair kieserekse reknslrsei
      781 erlqaeikri eercrrkled stretqsqle tersryqrei dklrqrpygs hretqtecew
      841 tvdtsklvfd glrkkvtamq lyecqlidkt tldkllkgkk sveevaseiq pflrgagsia
      901 gasaspkeky slveakrkkl ispestvmll eaqaatggii dphrnekltv dsaiardlid
      961 fddrqqiyaa ekaitgfddp fsgktvsvse aikknlidre tgmrlleaqi asggvvdpvn
     1021 svflpkdval arglidrdly rslndprdsq knfvdpvtkk kvsyvqlker criephtgll
     1081 llsvqkrsms fqgirqpvtv telvdsgilr pstvnelesg qisydevger ikdflqgssc
     1141 iagiynettk qklgiyeamk iglvrpgtal elleaqaatg fivdpvsnlr lpveeaykrg
     1201 lvgiefkekl lsaeravtgy ndpetgniis lfqamnkeli ekghgirlle aqiatggiid
     1261 pkeshrlpvd iaykrgyfne elseilsdps ddtkgffdpn teenltylql kercikdeet
     1321 glcllplkek kkqvqtsqkn tlrkrrvviv dpetnkemsv qeaykkglid yetfkelceq
     1381 eceweeitit gsdgstrvvl vdrktgsqyd iqdaidkglv drkffdqyrs gslsltqfad
     1441 mislkngvgt sssmgsgvsd dvfsssrhes vskistissv rnltirsssf sdtleesspi
     1501 aaifdtenle kisitegier givdsitgqr lleaqactgg iihpttgqkl slqdavsqgv
     1561 idqdmatsvk paqkafigfe gvkgkkkmsa aeavkekwlp yeagqrflef qyltgglvdp
     1621 evhgristee airkgfidgr aaqrlqdtss yakiltcpkt klkisykdai nrsmveditg
     1681 lrlleaasvs skglpspynm ssapgsrsgs rsgsrsgsrs gsrsgsrrgs fdatgnssys
     1741 ysysfssssi gh
//

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