CASP3 Target T0072

1. Protein Name

CD5 domain 1

2. Organism Name

human

3. Number of amino acids (approx)

110

4. Accession number

P06127

5. Sequence Database

Swiss-prot

6. Amino acid sequence

RLSWYD PDFQARLTRS NSKCQGQLEV YLKDGWHMVC
SQSWGRSSKQ WEDPSQASKV CQRLNCGVPL SLGPFLVTYT PQSSIICYGQ LGSFSNCSHS
RNDMCHSLGL TCLE

7. Homologous Sequence of known structure

yes

8. Current state of the experimental work

We have been working on this protein for a while now.
We are starting to get interpretable NMR spectra of N-15
labelled protein. It is not yet clear if this will be
sufficient to solve the structure without C-13 labelling also.
We may not have the structure by the deadline, but hopefully
we might have a low resolution picture of the fold by the
end of the year, and perhaps before. However if we waited until
CASP 4 it would be too late to make this a suitable target.

9. Interpretable map?

yes

10. Estimated date of chain tracing completion

see comments above

11. Estimated date of public release of structure

see comments above

12. Additional Information

This protein domain is an archetypal member of the Scavenger
Receptor Cysteine-Rich (SRCR) superfamily of domains. There
has been quite a lot of discussion of the possible structure
in the literature in the past. Some recent publications purport
to have identified the pairing of Cys residues in disulphide
bonds.

13. Name

Dr. Paul C. Driscoll

14. Mailing address

Department of Biochemistry and Molecular Biology
University College London
Gower Street
London, WC1E 6BT
U.K.

15. Telephone

44-171 380 7035

16. Fax

44-171 380 7193

17. Email

driscoll@biochem.ucl.ac.uk

18. Source of information about experiment

Newsgroup

Related Files

Template PDB file