UCSC BME 200 Fall 2014

Being a Biomolecular Engineering and Bioinformatics Grad Student

(Last Update: 15:30 PST 26 December 2014 )
This is a required course for graduate students in Biomolecular Engineering and Bioinformatics.

For catalog copy and pre-requisites, see the main page for BME200.

Who, When, and Where:

Instructor: Kevin Karplus ( karplus@soe.ucsc.edu) http://www.soe.ucsc.edu/~karplus
Office hours: PSB 318, W 4–5
+1-831-459-4250

lecture and discussion section (REQUIRED): PSB 305 Thurs 4–5:45 p.m.

Do not take BME 200 for a letter grade!

The lectures and discussions will cover topics specific to bioinformatics, including such things as lab safety and cultural differences between the academic cultures of biology and computer science, as well as more general graduate student stuff, such as how to write a research paper, avoiding sexual harassment, fellowships, library usage, LaTeX, teaching, speaking loudly, ...

All new grad students should also plan on taking BME 280B this quarter, since it will be a series of introductory lectures by faculty who can accept grad students into their labs for lab rotation projects.


Requirements to pass

There will be a small number of written assignments for this class: a LaTeX exercise, a library/BibTeX exercise, writing a fellowship or grant proposal, and a web page exercise.

The course is graded strictly on the Satisfactory/Unsatisfactory scale. Do not register for a letter grade.

Homework assignment: LaTeX assignment Due 16 Oct 2014. Reproduce the example in latex-assign.pdf using LaTeX.

Homework assignment: fellowship application Due Fri 24 Oct 2014 (joint with BME 205).

Homework assignment: LaTeX/BibTeX assignment Due 4 Dec 2014.

Homework assignment: Web page assignment Due Mon 15 Dec 2014 4 p.m. (exam slot for course)

Texts

Required:

Optional:

Academic Integrity

Anyone caught cheating in the class will be punished severely—most likely failed in the class and possibly thrown out of grad school. Cheating includes any attempt to claim someone else's work as your own. Plagiarism in any form (including close paraphrasing) will be considered cheating. Use of any source without proper citation will be considered cheating.

Collaboration without explicit written acknowledgment will be considered cheating. Collaboration on some assignments with explicit written acknowledgment is encouraged—guidelines for the extent of reasonable collaboration will be given in class.


Rogues' Gallery

Who is in the class this year. I'm trying to learn the names of this year's students. I'm hoping to have them all straight within 10 weeks. That doesn't sound very challenging with so few students, but I have real trouble with names.

Note: FERPA prohibits the dissemination of academic records without permission, and UCSC has taken the particularly paranoid view that any mention of a student could be considered an academic record. So pictures and names can't be posted here without student permission. Other faculty and grad students use these pictures to help get to know who the new students are (with our tiny department spread over 6 different floors in 4 buildings, a physical bulletin board of students wouldn't help much), so I encourage students to allow their names and pictures to be posted.

The pictures below have links to larger images.


XXX YYY

Tentative schedule of topics

Note: list should be updated throughout the quarter to reflect what really happens.

2 Oct 2014

Discuss textbooks and assignments, go over syllabus.

Tour rooms openable with BME grad key.

Handy tool for finding classrooms: http://maps.ucsc.edu/
Unfortunately, this map only gets you to the nearest building, and does not help with finding the desired room within the building, which can be quite challenging at some of the colleges.
List of classrooms with capacity and media equipment: http://its.ucsc.edu/classrooms/
Locations of bicycle "FixIt" stations on campus: http://ucscsustainability.blogspot.com/2013/04/new-bike-fixit-stations-installed.html
Web pages of seminars:
Biomolecular Engineering and Bioinformatics seminar
Microbiology and Environmental Toxicology Tuesdays 12–1 PSB 240
MCD Bio Seminar Mondays and Fridays 12:30–1:40 Nat Sci Annex 101
Chemistry Seminar MWF 3:30–4:40 PSB 240 (M,W,F have different foci)
Mailing lists:
compbio
optional, but highly recommended, mailing list: bioinformatics seminar announcements, jobs, bread-and-tea, ...
https://groups.google.com/a/soe.ucsc.edu/forum/?fromgroups#!forum/compbio
bme-grads
automatic, can't unsubscribe: official announcements from the department.
genecats
For developers of the genome browser, and comparative genomics research results.
https://groups.google.com/a/soe.ucsc.edu/forum/?fromgroups#!forum/genecats
bme-social
This mailing list is for Biomolecular Engineering and Bioinformatics grad students (and the computational biology track of PBSE). It is intended for informal, social stuff that involves primarily grad students, though postdocs, staff, and others are welcome to join. Formal announcements go to binf-grads and stuff of broader community interest (seminars, job opportunities, bread-and-tea, ... ) go to compbio. https://groups.google.com/a/soe.ucsc.edu/forum/?fromgroups#!forum/bme-social
bme-cbse-postdocs
For the postdocs and lab staff who aren't grad students or faculty. I believe that postdocs are supposed to be automatically signed up for this list, but I bet the maintenance is not all it should be, since there isn't a clear owner in charge who needs to contact the postdocs. This list may be obsolete.
TeX-users
(Created 21 April 2011) Mailing list for users of TeX and LaTeX. A good place to discuss style files, tools, home installation, and cool TeX resources. Also suitable for asking help questions of experts. Not for reporting bugs in the SoE installation—use the normal IT Request mechanism for that. This list still exists but has seen alomst no traffic in the past couple of years. https://groups.google.com/a/soe.ucsc.edu/forum/?fromgroups#!forum/tex-users
Science and Justice Working Group
http://scijust.ucsc.edu/ A biweekly interdisciplinary discussion group. "The Science and Justice Working Group brings together faculty and graduate students from all five academic divisions on the UC Santa Cruz campus-arts, humanities, social sciences, engineering, and physical and biological sciences-to promote interdisciplinary conversations and exchange. We expand UCSC's historical focus on social justice to include questions about the formation of science and technology, and related public-policy debates."
mcdseminars
Announcements of the topics for seminars in the Monday+Friday Molecular, Cell, and Developmental Biology series (12:30 in Nat Sci Annex 101) http://lists.pbsci.ucsc.edu/mailman/listinfo/mcdseminars
pdb-l
Users mailing list for the Protein Data Bank. Often has questions about tools and interpretation of protein models, resulting in tutorial replies.
See https://lists.sdsc.edu/mailman/listinfo.cgi/pdb-l for more information.
molvis-list
Molecular visualization mailing list.
See http://bioinformatics.org/mailman/listinfo/molvis-list
proteopedia list
Proteopedia users. See http://www.bioinformatics.org/mailman/listinfo/proteopedialist-for-users for more information about the proteopedia mailing list. Proteopedia itself can be found at proteopedia.org
Blogs:
There are many blogs that talk about life as a grad student, a scientist, a researcher, an academic, a teacher, and so forth. Here are a few that may be worth following:
Female Science Professor
Musings about being a professor, about sexism in academia, about mentoring, about running a lab, about job searches, ... . This blog has dropped way down in frequency over the past year.

If you like this blog, you might want to check out others on this list of blogs by female scientists: http://www.guardian.co.uk/science/the-lay-scientist/2010/sep/16/women-science-blogging , though it might be a bit UK-centric.

Jack Baskin School of Engineering News
Not a blog, but an RSS feed for press releases from the School of Engineering. The BME faculty get written up fairly often (awards, big grants, exciting research results, ..)
Gas Station Without Pumps
Various musings on teaching, bioinformatics, being an academic, home schooling, ...
Privacy of student records
In 2014, faculty were sent the following information:
This reminder is being sent to every instructor teaching a class this quarter. Instructors' access to confidential student information is accompanied by a responsibility for understanding and following the University's policy on the privacy of student records. Instructors must also avoid inadvertent disclosure by ensuring that identifiable student work is not placed in an unmonitored area for students to pick up, and by shredding printed material that contains sensitive or restricted data. A printable quick guide and a faculty guide, FERPA for Faculty, may be found on the Registrar's Privacy of Student Records website in the Resources section. In addition to reviewing these references, we recommend you complete the training on the Family Educational Rights and Privacy Act (FERPA) of 1974.
There is more information on the UCSC Privacy of Student Records web page.
9 Oct 2014

TAships and union activity

Instructor Checklist for TAs. All TAs need to consult with the instructor they are working for, and discuss the TA responsibilities at the beginning of the quarter. Once both parties agree on what the TA needs to do, they need to sign the checklist. This is a requirement of the job. The checklist forms can be found on http://ga.soe.ucsc.edu/current/forms, and you can compare these with the union's information at http://www.uaw2865.org/member-resources/. They have a generic checklist on their page http://www.uaw2865.org/member-resources/ase-checklist/

Handout on Center for Teaching and Learning and their services: TA Starter Package "Services provided by CTL have been suspended for budgetary purposes until further notice."

I have been strongly warned that as a faculty member I am "management" and not allowed to talk to you about the TA union, nor how to start or avoid the union grievance process. You are on your own for figuring that out. (Sorry---we used to have good discussions in this class how what the legal options were during strikes, about the strategic difficulties of strikes as a bargaining tool for teachers and public employees, and where you could get more information, but I've been told I can't even get someone else to present the information.) Contacting your union steward:
UAW Local 2865 310 Locust St., Suite B / Mailbox 2
Santa Cruz, CA 95060
Fax (831) 423-3606
santacruz@uaw2865.org
http://www.uaw2865.org/home/home.php

Note: TAs are not allowed to have office hours in shared grad-student space. TA office hours are to be scheduled in Baskin Engineering 312 C and D by Tracie Tucker. See http://ga.soe.ucsc.edu/ta/office-hours for more information.

There have been grad computing labs in Baskin 314A and 316, for which you would need keys different from the BME grad key that opens the labs in Physical Sciences Building—few BME students have opted to use the Baskin computers.

Discussion of faculty union SCFA, which I am a member of. Brief mention of AAUP and their publication Academe, which is available on-line as http://www.aaup.org/AAUP/pubsres/academe/

Practice speaking loudly

Homework assignment: LaTeX assignment

The purpose of this assignment is to develop some preliminary facility with LaTeX, particularly with math equations and tables. You are to try to duplicate (approximately) the 2-page paper in latex-assign.pdf

Go over some examples of a basic LaTeX paper in example.tex and the corresponding output example.pdf. You can use "make" to do the repeated calls to latex with the Makefile

I strongly recommend using LaTeX for thesis proposals and theses. There is a style file available (which should be a good starting point at least) in http://www.soe.ucsc.edu/~you/notes/ucthesis-ucsc/

There is a cool tool for guessing the LaTeX code for hand-drawn symbols at http://detexify.kirelabs.org/classify.html Personally, I find it faster to scan a list of symbols (particularly since drawing with a touch pad on a laptop is tough), but others may find this drawing approach useful. The comprehensive list at http://www.tex.ac.uk/tex-archive/info/symbols/comprehensive/symbols-a4.pdf is a useful one.

Cover preparing a document with LaTeX. Using a Makefile and gnumake to run LaTeX, BibTeX, dvips, and distill. Explain difference between distill and ps2pdf, and talk about how to set up ssh to do passphraseless ssh to apache or sundance to run distill.

Setting up your PRINTER environment variable correctly: see instructions at http://support.soe.ucsc.edu/printing

I use the small distribution BasicTex on my Mac, because it is quick to download, takes up little disk space (only 86Mbytes), and has everything I use. Some people prefer a GUI interface like TeXWorks.

Turn in both the .tex source and the printed output at the beginning of class.

16 Oct 2014
  • Guest speaker: Tracey Tsugawa, Sexual Harassment/Title IX. Handouts from last year (update if Tracey brings others). Mention the report Annual Campus Security and Fire Safety Report 2013, which is 69 pages long, but has a lot of good stuff in it. The list of prevention programs and the crime statistics are what change most from year to year.
  • Classroom accommodations for disabilities
    The Dean for Undergraduate Education (William Ladusaw) recommends incorporating the following paragraph into all syllabi: "If you qualify for classroom accommodations because of a disability, please submit your Accommodation Authorization from the Disability Resource Center (DRC) to me during my office hours in a timely manner, preferably within the first two weeks of the quarter. Contact DRC at 459-2089 (voice), 459-4807 (TTY)."

    The DRC has provided an updated and comprehensive faculty resource page at: http://drc.ucsc.edu/fac-staff/faculty/index.html and they call particular attention to exam accommodation: http://drc.ucsc.edu/fac-staff/faculty/faculty-exam-sheet.html They also have a link to requirements of the Americans with Disabilities Act (ADA) for grad students as employees, students, teachers, providers of public service, and web developers.

    I used to have a lot of links to DRC resources, but they have scrambled their web page since then, so that none of the links are good any more. Note: this is standard practice at UCSC—there is not much point in keeping bookmarks for long, as the web masters on campus believe in scrambling the web pages frequently. Learn some keywords and do Google searches, and hope that the frequent web scrambling doesn't cause the information you need to disappear completely.

  • 23 Oct 2014
    Guest lecture by tech staff on computer and cluster use by bioinformatics grad students.
    Where things are kept, how to get access to cluster computing. How to report problems (email: cluster-admin, http://itrequest.ucsc.edu)
    Review of LaTeX assignment.
    • The main missed point on LaTeX was that several people did not use the \label and \ref commands for creating cross-references.
    • The trick for unaligning the first line was rather ugly:
          \begin{eqnarray}
          \hbox to 5pt{$E(c^2) =$ \hskip 0pt minus 1fill} & & \nonumber\\
      	    &=& \lambda^{-2} \int_{-\infty}^{\infty}  {y^2\over(1+e^{y})(1+e^{-y})}   dy \\
      
          
    • Trick for getting good-looking conditional probability:
          \newcommand{\prob}{\mbox{Prob}}
          \newcommand{\bfgiven}{\mathchoice{\mathrel{\Bigl|}}{\mathrel{\bigl|}}{\mathrel{\bigl|}}{\mathrel{|}}}
          \newcommand{\condprob}[2]{\prob\left( #1 \bfgiven #2 \right)}
          
    • Left quotes with ``
    • Using unbreakable space (~) after non-sentence-ending period.
    • Using ~. to end sentence in display math
    • Distinguishing \Pi from \prod
    30 Oct 2014
    Guest lecture: Lab safety and computer ergonomics, guest lecturers: Lisa Wisser and Brian MacDonald, EHS.
    Jumping into toxic waste does not give
				you super powers
    (Image cleaned up from http://chzoddlyspecific.files.wordpress.com/2010/07/ecd7fef9-6190-4efe-b70d-84608866d526.jpg)

    The ergonomics resources can be found at the bottom of http://ehs.ucsc.edu/programs/ergo/index.html

    The lab safety information can be found using the left-navigation panel of http://ehs.ucsc.edu/programs/research-safety/index.html

    6 Nov 2014
    Discussion of advancement to candidacy and thesis committees.
    Discussion of elevator talks.
    Cultural differences in who is included as co-author on a paper. ... Who is an author? NIH's Office or Research Integrity has an article on different meanings of authorship in different fields in their Sept 2009 newsletter
    13 Nov 2014

    Not covered in class, but possibly useful for BibTeX assignment:

    • Selecting slots for presenting Teach Like a Champion topics.
    • BibTeX: citation databases in LaTeX.
      How to use the tools John Archie created and the existing database in
      /projects/compbio/papers/tex/citations.bib
      
      Put
      setenv BIBINPUTS .:/projects/compbio/papers/tex::
      
      in your .cshrc file and say \bibliography{full-journals,my,citations,crossrefs} to include both your file my.bib and /projects/compbio/papers/tex/citations.bib in your search for bibliography entries. (See the notes at the beginning of citations.bib for more info, including fancy tools like pmid2bib and update-journals.)
    • Pictures in papers: (use graphics package or older epsfig package) Should mention subfigure package and give examples.
    • Oral presentation (ideas behind 2-minute elevator talk). Tools for designing your slides (PowerPoint, keynote, LaTeX+acroread). Frequent failure of embedded video. http://teachers.net/gazette/wordpress/tim-newlin/powerpoint-pandemic/ Preparing slides (Beamer package in LaTeX).
    • How to Write a Scientific Paper by E. Robert Schulman Annals of Improbable Research, Vol. 2, No. 5, pg. 8.
    • Responsibilities for research integrity. All authors at fault for any errors or fraud. http://www.canada.com/University+Waterloo+researchers+issue+retraction+apology+after+using+expert+text+information/7226185/story.html
    • Teaching techniques (from Teach Like a Champion) intro.
    • Another good lecture/article on learning to teach: "The Problem of Learning to Teach" P. R. Halmos, E. E. Moise and George Piranian The American Mathematical Monthly, Vol. 82, No. 5 (May, 1975), pp. 466-476 Published by: Mathematical Association of America Article Stable URL: http://www.jstor.org/stable/2319737
    • Intellectual property, patents, and software copyright. See the ISCB statement on software sharing at http://www.iscb.org/iscb-policy-statements/software_sharing and their policy statement on open-access publishing at http://www.iscb.org/iscb-policy-statements/literature_open_access
    • Choosing a journal. Open-access or subscriber?
    • How to produce posters, mainly design and where to print: the School of Engineering poster printer (free for SoE posters). Some discussion of design guidelines.
    • Instructions for setting up SoE web pages, turning on directory indexing, and similar stuff is on http://support.soe.ucsc.edu/web/personal General discussion on presentation of data.
    • Lab rotation talks. What they are, when we'll have them, how to prepare.
    20 Nov 2014
    student presentations of techniques from Doug Lemov's Teach Like a Champion: 49 Techniques that Put Students on the Path to College
    4 Dec 2014
    Feedback on student presentations of techniques from Doug Lemov's Teach Like a Champion: 49 Techniques that Put Students on the Path to College
    11 Dec 2014
    • Instructor evaluation.
    • More feedback on student presentations of techniques from Doug Lemov's Teach Like a Champion: 49 Techniques that Put Students on the Path to College
    Mon 15 Dec 2014, 4 p.m.–7 p.m.
    Final exam slot, not used. (4pm final deadline for all homework)

    Topics that haven't been scheduled, but probably should be

    Writing proposals (thesis proposals, funding applications, ...) (Covered in BME 205.)

    Over 20 examples of thesis proposals that passed can be found on the BSoE file servers at /projects/compbio/papers/thesis-proposals/

    Funding sources.

    Useful resources

    URLs not checked yet for Fall 2014

    baskin-icon
    SoE home
    sketch of Kevin Karplus by Abe
    Kevin Karplus's home page
    BME-slug-icon
    Biomolecular Engineering Department
    Questions about page content should be directed to Kevin Karplus
    Biomolecular Engineering
    University of California, Santa Cruz
    Santa Cruz, CA 95064
    USA
    karplus@soe.ucsc.edu
    1-831-459-4250
    318 Physical Sciences Building

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