Abstract: Escherichia coli O157:H7 is a major food-borne infectious pathogen that causes diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome. Here we report the complete chromosome sequence of an O157:H7 strain isolated from the Sakai outbreak, and the results of genomic comparison with a benign laboratory strain, K-12 MG1655. The chromosome is 5.5 Mb in size, 859 Kb larger than that of K-12. We identified a 4.1-Mb sequence highly conserved between the two strains, which may represent the fundamental backbone of the E. coli chromosome. The remaining 1.4-Mb sequence comprises of O157:H7-specific sequences, most of which are horizontally transferred foreign DNAs. The predominant roles of bacteriophages in the emergence of O157:H7 is evident by the presence of 24 prophages and prophage-like el... [Click above reference link for full abstract]
A genome position can be specified by chromosomal coordinate range, COG
ID, or keywords from the GenBank or TIGR description of a gene.
The available chromosome/plasmid names are:
Browser Chrom/Plasmid Name | Length (bp) | GC Content (%) | Gene Count | NCBI RefSeq Accession |
---|---|---|---|---|
plasmid_pOSAK1 | 3306 | 43.41 | 3 | NC_002127 |
plasmid_pO157 | 92721 | 47.60 | 85 | NC_002128 |
chr | 5498450 | 50.54 | 5395 | NC_002695 |
The following list shows examples of valid position queries for this genome:
Request: | Genome Browser Response: |
---|---|
chr | Displays the entire sequence "chr" in the browser window |
chr:1-10000 | Displays first ten thousand bases of the sequence "chr" |
transporter | Lists all genes with "transporter" in the name or description |
pO157p06 | Display genome at position of gene pO157p06 |
If you use the browser in your published research, please cite our publication in the Nucleic Acids Research Database Issue. Citations and positive feedback will help us obtain funding to continue development of this community resource.