We focus primarily on the application of systems and control theory to research problems in single-molecule instrumentation, biotechnology and biophysics using nanopores.Funding sources for research involving biological and solid-state nanopores include NIH, NSF and the W.M. Keck Foundation.
Check out our review paper in Electrophoresis, Recent Advances in Nanopore Sequencing, May 2012.
June, 2013 PhD student Christopher O'Donnell is lead author on our new paper in Electrophoresis, Error Analysis of Idealized Nanopore Sequencing. Following our review paper from 2012, we asked the question: "How many times do you need to read each DNA molecule with a nanopore to get acceptable sequencing error?" That's exactly what our study examines, assuming idealized enzyme-controlled DNA rate control and ionic current sensing. Great paper Chris!
June, 2013 Graduate student Raj Maitra successfully finished his MS, having co-authored several journal paper, including the nanopore sequencing review paper cited above.
May, 2013 New paper entitled Measuring and Modeling the Kinetics of Individual DNA-DNA Polymerase Complexes on a Nanopore in ACS Nano. By using active control of individual DNA in the biological nanopore, we recorded and analyzed over 200,000 single-molecule events in this study! That's two orders of magnitude more than the typical number of events (a few thousand) recorded in standard nanopore capture experiments that don't use control.
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