From the Vega main page:
The Vertebrate Genome Annotation (VEGA) database is designed to be a central repository for manual annotation of different vertebrate finished genome sequence. In collaboration with the genome sequencing centres Vega attempts to present consistent high-quality curation of the published chromosome sequences.
Finished genomic sequence is analysed on a clone by clone basis using a combination of similarity searches against DNA and protein databases as well as a series of ab initio gene predictions (GENSCAN, Fgenes).
In addition, comparative analysis using vertebrate datasets such as the Riken mouse cDNAs and Genoscope Tetraodon nigroviridis Ecores (Evolutionary Conserved Regions) are used for novel gene discovery.
NOTE: VEGA annotations appear only on chromosomes 6, 7, 13, 14, 20, and 22.
Thanks to Steve Searle at the Sanger Institute for providing GTF and FASTA for the Vega annotations.
Vega gene annotations are generated by manual annotation from the following groups.