; SAM: /projects/compbio/experiments/protein-predict/SAM_T08test/bin_freeze/sam/prettyalign v3.5 (July 15, 2005) compiled 04/12/08_09:06:02 ; (c) 1992-2001 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ----------------- Citations (SAM, SAM-T2K, HMMs) -------------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, et al., What is the value added by human intervention in protein ; structure prediction, Proteins: Stucture, Function, Genetics 45(S5):86--91, 2001. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; --------------------------------------------------------------------- ; Sequences correspond to the following labels: ; 1 T0465 yqbN, Bacillus subtilis, 157 residues ; 2 gi|52785107|ref|YP_090936.1|_1:149 XkdN1 [Bacillus licheniformis ATCC 14580] >gi|52347609|gb|AAU40243.1| XkdN1 [Bacillus licheniformis DSM 13] ; 3 gi|16079657|ref|NP_390481.1|_1:149 hypothetical protein BSU26040 [Bacillus subtilis subsp. subtilis str. 168] >gi|1176753|sp|P45930|YQBN_BACSU Uncharacterized protein yqbN >gi|1217861|dbj|BAA06946.1| ORF55 [Bacillus subtilis] >gi|1303754|dbj|BAA12410.1| YqbN [Bacillus subtilis] >gi|2635049|emb|CAB14545.1| yqbN [Bacillus subtilis subsp. subtilis str. 168] ; 4 gi|16078332|ref|NP_389149.1|_1:156 hypothetical protein BSU12670 [Bacillus subtilis subsp. subtilis str. 168] >gi|1722871|sp|P54333|XKDN_BACSU Phage-like element PBSX protein xkdN >gi|1225952|emb|CAA94036.1| xkdN [Bacillus subtilis] >gi|2633621|emb|CAB13124.1| xkdN [Bacillus subtilis subsp. subtilis str. 168] ; 5 gi|157693512|ref|YP_001487974.1|_1:146 hypothetical bacteriophage protein [Bacillus pumilus SAFR-032] >gi|157682270|gb|ABV63414.1| hypothetical bacteriophage protein [Bacillus pumilus SAFR-032] ; 6 gi|126698538|ref|YP_001087435.1|_1:146 phage protein [Clostridium difficile 630] >gi|126700526|ref|YP_001089423.1| phage protein [Clostridium difficile 630] >gi|145955396|ref|ZP_01804398.1| hypothetical protein CdifQ_04001113 [Clostridium difficile QCD-32g58] >gi|168693904|ref|ZP_02726181.1| phage protein [Clostridium difficile QCD-37x79] >gi|168724061|ref|ZP_02756338.1| phage protein [Clostridium difficile QCD-76w55] >gi|168731767|ref|ZP_02764044.1| phage protein [Clostridium difficile QCD-97b34] >gi|115249975|emb|CAJ67795.1| phage protein [Clostridium difficile 630] >gi|115251963|emb|CAJ69799.1| phage protein [Clostridium difficile 630] ; 7 gi|168714500|ref|ZP_02746777.1|_1:146 phage protein [Clostridium difficile QCD-63q42] ; 8 gi|169827347|ref|YP_001697505.1|_1:144 XkdN1 [Lysinibacillus sphaericus C3-41] >gi|168991835|gb|ACA39375.1| XkdN1 [Lysinibacillus sphaericus C3-41] ; 9 gi|134287351|ref|YP_001110734.1|_1:146 hypothetical protein phiC2p16 [Clostridium phage phiC2] >gi|93117189|gb|ABE99479.1| hypothetical protein phiC2p16 [Clostridium phage phiC2] ; 10 gi|126650061|ref|ZP_01722294.1|_1:144 XkdN1 [Bacillus sp. B14905] >gi|126593233|gb|EAZ87195.1| XkdN1 [Bacillus sp. B14905] ; 11 gi|148379694|ref|YP_001254235.1|_1:137 phage protein [Clostridium botulinum A str. ATCC 3502] >gi|148289178|emb|CAL83272.1| putative phage protein [Clostridium botulinum A str. ATCC 3502] ; 12 gi|168708891|ref|ZP_02741168.1|_1:146 phage protein [Clostridium difficile QCD-63q42] ; 13 gi|167462289|ref|ZP_02327378.1|_4:141 phage protein [Paenibacillus larvae subsp. larvae BRL-230010] ; 14 gi|168178739|ref|ZP_02613403.1|_1:137 conserved hypothetical protein [Clostridium botulinum NCTC 2916] >gi|182671202|gb|EDT83176.1| conserved hypothetical protein [Clostridium botulinum NCTC 2916] ; 15 gi|168179424|ref|ZP_02614088.1|_1:137 conserved hypothetical protein [Clostridium botulinum NCTC 2916] >gi|182669847|gb|EDT81823.1| conserved hypothetical protein [Clostridium botulinum NCTC 2916] ; 16 gi|167770421|ref|ZP_02442474.1|_1:144 hypothetical protein ANACOL_01764 [Anaerotruncus colihominis DSM 17241] >gi|167667428|gb|EDS11558.1| hypothetical protein ANACOL_01764 [Anaerotruncus colihominis DSM 17241] ; 17 gi|153941040|ref|YP_001391647.1|_1:137 hypothetical protein CLI_2405 [Clostridium botulinum F str. Langeland] >gi|152936936|gb|ABS42434.1| conserved hypothetical protein [Clostridium botulinum F str. Langeland] ; 18 gi|160881084|ref|YP_001560052.1|_1:143 XkdN-like protein [Clostridium phytofermentans ISDg] >gi|160429750|gb|ABX43313.1| XkdN-like protein [Clostridium phytofermentans ISDg] ; 19 gi|167463522|ref|ZP_02328611.1|_1:140 phage protein [Paenibacillus larvae subsp. larvae BRL-230010] ; 20 gi|168185999|ref|ZP_02620634.1|_1:137 phage protein [Clostridium botulinum C str. Eklund] >gi|169296039|gb|EDS78172.1| phage protein [Clostridium botulinum C str. Eklund] ; 21 gi|160878945|ref|YP_001557913.1|_1:142 XkdN-like protein [Clostridium phytofermentans ISDg] >gi|160427611|gb|ABX41174.1| XkdN-like protein [Clostridium phytofermentans ISDg] ; 22 gi|89896701|ref|YP_520188.1|_1:137 hypothetical protein DSY3955 [Desulfitobacterium hafniense Y51] >gi|109647327|ref|ZP_01371231.1| XkdN1 [Desulfitobacterium hafniense DCB-2] >gi|89336149|dbj|BAE85744.1| hypothetical protein [Desulfitobacterium hafniense Y51] >gi|109642573|gb|EAT52127.1| XkdN1 [Desulfitobacterium hafniense DCB-2] ; 23 gi|153954568|ref|YP_001395333.1|_1:150 hypothetical protein CKL_1950 [Clostridium kluyveri DSM 555] >gi|146347426|gb|EDK33962.1| Conserved hypothetical protein [Clostridium kluyveri DSM 555] ; 24 gi|16800349|ref|NP_470617.1|_10:162 hypothetical protein lin1280 [Listeria innocua Clip11262] >gi|16413754|emb|CAC96511.1| lin1280 [Listeria innocua] ; 25 gi|153954477|ref|YP_001395242.1|_1:150 XkdN-related protein [Clostridium kluyveri DSM 555] >gi|146347358|gb|EDK33894.1| XkdN-related protein [Clostridium kluyveri DSM 555] ; 26 gi|188587578|ref|YP_001920287.1|_1:137 putative phage protein [Clostridium botulinum E3 str. Alaska E43] >gi|188497859|gb|ACD50995.1| putative phage protein [Clostridium botulinum E3 str. Alaska E43] ; 27 gi|153955865|ref|YP_001396630.1|_1:144 hypothetical protein CKL_3256 [Clostridium kluyveri DSM 555] >gi|146348723|gb|EDK35259.1| Conserved hypothetical protein [Clostridium kluyveri DSM 555] ; 28 gi|125974972|ref|YP_001038882.1|_1:136 hypothetical protein Cthe_2487 [Clostridium thermocellum ATCC 27405] >gi|125715197|gb|ABN53689.1| conserved hypothetical protein [Clostridium thermocellum ATCC 27405] ; 29 gi|116629278|ref|YP_814450.1|_1:139 Core tail protein [Lactobacillus gasseri ATCC 33323] >gi|116629338|ref|YP_814510.1| Phage related protein [Lactobacillus gasseri ATCC 33323] >gi|116094860|gb|ABJ60012.1| Core tail protein [Lactobacillus gasseri ATCC 33323] >gi|116094920|gb|ABJ60072.1| Phage related protein [Lactobacillus gasseri ATCC 33323] ; 30 gi|90592622|ref|YP_529882.1|_1:139 hypothetical protein LGPKV5a_gp47 [Lactobacillus phage KC5a] >gi|89891951|gb|ABD78824.1| hypothetical protein [Lactobacillus gasseri phage KC5a] ; 31 gi|148380291|ref|YP_001254832.1|_1:145 hypothetical protein CBO2340 [Clostridium botulinum A str. ATCC 3502] >gi|148289775|emb|CAL83883.1| hypothetical phage protein [Clostridium botulinum A str. ATCC 3502] ; 32 gi|163932194|ref|YP_001642384.1|_1:139 hypothetical protein LJ771_041 [Lactobacillus johnsonii prophage Lj771] >gi|163562148|gb|ABY27004.1| hypothetical protein LJ771_041 [Lactobacillus johnsonii prophage Lj771] ; 33 gi|169185014|ref|ZP_02845177.1|_1:135 XkdN-like protein [Paenibacillus sp. JDR-2] >gi|169007929|gb|EDS54777.1| XkdN-like protein [Paenibacillus sp. JDR-2] ; 34 gi|150016525|ref|YP_001308779.1|_1:143 Phage XkdN-like protein [Clostridium beijerinckii NCIMB 8052] >gi|149902990|gb|ABR33823.1| Phage XkdN-like protein [Clostridium beijerinckii NCIMB 8052] ; 35 gi|153810680|ref|ZP_01963348.1|_10:183 hypothetical protein RUMOBE_01064 [Ruminococcus obeum ATCC 29174] >gi|149833076|gb|EDM88158.1| hypothetical protein RUMOBE_01064 [Ruminococcus obeum ATCC 29174] ; 36 gi|145955100|ref|ZP_01804104.1|_1:148 hypothetical protein CdifQ_04001511 [Clostridium difficile QCD-32g58] >gi|168696304|ref|ZP_02728581.1| hypothetical protein CdifQCD_12691 [Clostridium difficile QCD-37x79] >gi|168714438|ref|ZP_02746715.1| hypothetical protein CdifQCD-6_12308 [Clostridium difficile QCD-63q42] >gi|168723331|ref|ZP_02755608.1| hypothetical protein CdifQCD-7_03041 [Clostridium difficile QCD-76w55] >gi|168730964|ref|ZP_02763241.1| hypothetical protein CdifQCD-_06620 [Clostridium difficile QCD-97b34] ; 37 gi|187932802|ref|YP_001886914.1|_1:146 hypothetical phage protein [Clostridium botulinum B str. Eklund 17B] >gi|187720955|gb|ACD22176.1| hypothetical phage protein [Clostridium botulinum B str. Eklund 17B] ; 38 gi|150390328|ref|YP_001320377.1|_11:149 Phage XkdN-like protein [Alkaliphilus metalliredigens QYMF] >gi|149950190|gb|ABR48718.1| Phage XkdN-like protein [Alkaliphilus metalliredigens QYMF] ; 39 gi|126698965|ref|YP_001087862.1|_1:148 hypothetical protein CD1365 [Clostridium difficile 630] >gi|115250402|emb|CAJ68224.1| conserved hypothetical protein [Clostridium difficile 630] ; 40 gi|39653729|ref|NP_945294.1|_1:141 hypothetical protein EJ-1p55 [Streptococcus phage EJ-1] >gi|38638897|emb|CAE82137.1| hypothetical protein [Bacteriophage EJ-1] ; 41 gi|90592652|ref|YP_529567.1|_11:156 XkdN protein [Clostridium phage phi CD119] >gi|61697931|gb|AAX53476.1| XkdN protein [Clostridium difficile bacteriophage phi CD119] ; 42 gi|28211738|ref|NP_782682.1|_1:135 hypothetical protein CTC02122 [Clostridium tetani E88] >gi|28204180|gb|AAO36619.1| conserved protein [Clostridium tetani E88] ; 43 gi|187604630|ref|ZP_02990837.1|_1:149 phage XkdN-like protein [Exiguobacterium sp. AT1b] >gi|187483289|gb|EDU21286.1| phage XkdN-like protein [Exiguobacterium sp. AT1b] ; 44 gi|168694729|ref|ZP_02727006.1|_1:138 hypothetical protein CdifQCD_04685 [Clostridium difficile QCD-37x79] >gi|168715684|ref|ZP_02747961.1| hypothetical protein CdifQCD-6_18171 [Clostridium difficile QCD-63q42] ; 45 gi|150390186|ref|YP_001320235.1|_1:135 hypothetical protein Amet_2422 [Alkaliphilus metalliredigens QYMF] >gi|149950048|gb|ABR48576.1| hypothetical protein Amet_2422 [Alkaliphilus metalliredigens QYMF] ; 46 gi|167767968|ref|ZP_02440021.1|_1:163 hypothetical protein CLOSS21_02511 [Clostridium sp. SS2/1] >gi|167710297|gb|EDS20876.1| hypothetical protein CLOSS21_02511 [Clostridium sp. SS2/1] ; 47 gi|168726643|ref|ZP_02758920.1|_1:138 hypothetical protein CdifQCD-7_19793 [Clostridium difficile QCD-76w55] >gi|168732421|ref|ZP_02764698.1| hypothetical protein CdifQCD-_14018 [Clostridium difficile QCD-97b34] ; 48 gi|167745915|ref|ZP_02418042.1|_10:168 hypothetical protein ANACAC_00609 [Anaerostipes caccae DSM 14662] >gi|167654430|gb|EDR98559.1| hypothetical protein ANACAC_00609 [Anaerostipes caccae DSM 14662] ; 49 gi|150018224|ref|YP_001310478.1|_1:133 Phage XkdN-like protein [Clostridium beijerinckii NCIMB 8052] >gi|149904689|gb|ABR35522.1| Phage XkdN-like protein [Clostridium beijerinckii NCIMB 8052] ; 50 gi|109648029|ref|ZP_01371932.1|_1:121 conserved hypothetical protein [Desulfitobacterium hafniense DCB-2] >gi|109641119|gb|EAT50674.1| conserved hypothetical protein [Desulfitobacterium hafniense DCB-2] ; 51 gi|182418566|ref|ZP_02626736.2|_3:131 hypothetical protein CBY_3271 [Clostridium butyricum 5521] >gi|182377569|gb|EDT75120.1| hypothetical protein CBY_3271 [Clostridium butyricum 5521] ; 52 gi|167769223|ref|ZP_02441276.1|_1:142 hypothetical protein ANACOL_00546 [Anaerotruncus colihominis DSM 17241] >gi|167668863|gb|EDS12993.1| hypothetical protein ANACOL_00546 [Anaerotruncus colihominis DSM 17241] ; 53 gi|182418975|ref|ZP_02950231.1|_1:132 hypothetical protein CBY_2545 [Clostridium butyricum 5521] >gi|182377258|gb|EDT74826.1| hypothetical protein CBY_2545 [Clostridium butyricum 5521] 10 20 30 40 | | | | 1 ...M..SENQNEKV.Y...DL.SFFMPG.QTID..AEEVEVP..IS..KRF.VD..KEGN.V.VP 2 ...M..SEKQEEKV.Y...DL.SFFMPG.QTVE..AEEIKVP..IS..KRF.VD..KKGN.V.IP 3 ...M..SENQNEKV.Y...DL.SFFMPG.QTID..AEEVEVP..IS..KRF.VD..KEGN.V.VP 4 ...M..SEKN-ENV.Y...DL.SFFMPG.KTIE..AEEIKVP..IS..KRF.VD..KKGN.V.IP 5 ...-..--MSEKQT.F...DL.SFFMPG.QTVE..AEEVKVP..IS..KRF.VD..KKGN.V.IP 6 ...-..-------M.S...NL.SAFLSQ.NAIK..VDNVKYV..AS..NRF.LD..KEGK.P.VE 7 ...-..-------M.S...NL.SAFLSQ.NAIK..VDNVKYI..AS..DRF.LD..EEGK.P.VE 8 ...-..-------M.S...NL.TAFFAH.NKKQ..NENIKHA..IS..KKF.VD..EQGN.P.IE 9 ...-..-------M.G...DL.NAFLSQ.NAIK..VENRKYV..AS..ERF.IG..EDGK.A.IE 10 ...-..-------M.S...NL.TAFFAH.NKKQ..NENIKHA..IS..KKF.VD..EQGH.P.IE 11 ...-..-------M.N...NF.EDFLMD.SFEE..VEEIE--..--..-RE.IT..IGGK.K.KK 12 ...-..-------M.G...DL.NAFLSQ.NAIK..VENRKYV..AS..NRF.IN..EEGK.A.IE 13 ...-..-------MsG...GL.QAFFAQ.EAGE..AITEKVV..VS..DRF.KD..KDGK.P.VP 14 ...-..-------M.N...NF.EDFLMD.SFEE..VEEIE--..--..-RE.IT..IGGK.K.KK 15 ...-..-------M.N...NF.EDFLMD.SFEE..VEEIE--..--..-RE.IT..IGGK.K.KK 16 ...-..-----MKMaG...GL.SAFLAQ.NAVK..PENIRFA..AS..RRF.VD..EDGK.P.ML 17 ...-..-------M.N...NF.EDFLMD.SFEE..VEEIE--..--..-RE.IT..IGGK.K.KK 18 ...-..-------M.S...NF.NRFMKQ.NKVQ..KENTTYP..AT..KSL.TD..EKGN.P.LL 19 ...-..-------M.S...DL.SLFYAQ.NAEA..GIMEEFA..VS..NRF.KT..KDGK.P.VL 20 ...-..-------M.S...QF.EDFLID.SFED..VEEVE--..--..-KE.LE..IGGR.K.RK 21 ...-..--------.M...SL.QLFMKK.NKKV..KENVFYA..PT..KSL.LD..ENGL.P.LN 22 ...-..-------M.S...DL.QDFLMD.NFEE..AEPIE--..--..-RR.VS..LGGK.E.KI 23 ...-..--MDIEKM.Q...NMsEDDIID.AL--..LGEIEVP..TR..TVV.IQ..RLG-.-.IP 24 iekV..EESNEELV.Y...DI.TAFLPG.KHEE..KVKLERA..VS..NRF.KD..KNGN.V.IK 25 ...-..--MDIEKM.Q...NMsEDDVID.AL--..LGEIEVP..TR..TVV.IQ..RLG-.-.IP 26 ...-..-------M.N...NF.EDFLMD.SFED..TQEIE--..--..-RE.VT..IGGK.K.KL 27 ...M..KKMTDEQI.L...SMkEEDILA.KL--..MGTYEVP..TA..TVF.IE..RMG-.-.IP 28 ...-..-------M.Slg.SL.EAFL--.NPVK..VENKKVI..VS..NRF.KD..KDGN.L.VP 29 ...-..--------.-...--.---MAE.SVEDflFENVGSP..VE..EKE.VK..LERF.K.SP 30 ...-..--------.-...--.---MAE.SVEDflFENVGSP..VE..EKE.IK..LERF.K.SP 31 ...MsnEKIKDEEI.L...NMtEEDIIN.RL--..MEPDEVP..EA..TYF.IE..RLR-.-.IP 32 ...-..--------.-...--.---MAE.SVEDflFENVGSP..VE..EKE.VK..LERF.K.SP 33 ...-..--------.M...NL.QEFLNN.HPVD..NLTEEII..VS..PRF.KD..ADGL.P.LK 34 ...M..KKNEKDEV.L...AMkEEDILA.KL--..LETHDVP..TA..NIQ.VP..RLG-.-.IA 35 pynF..EKMEEKRMgI...DM.KAFMKP.ELKD..RGTMEFP..GI..ERY.KD..AKGN.V.IP 36 ...M..NENGLSKN.I...NI.VDLLLNaDTEN..LERPSTI..VEl.KRL.ST..IFGQ.E.FK 37 ...M..N--TENNV.L...EMqEEDIIK.KL--..LGEVEVP..KA..VVV.IE..RIG-.-.IP 38 ...IleEELTEEEM.I...EMsEDDIIN.KL--..LEPSDAP..ER..TYA.IE..RLG-.-.IQ 39 ...M..SENGLLKN.I...NI.VDLLLNaDTEN..LERPSTI..VEl.KRL.ST..IFGQ.E.FK 40 ...-..--------.M...AI.SDFLLE.NVQQ..EETKEVH..L-..KRF.KS..----.-.-P 41 keiV..DKKEATEV.K...NI.VELLLK.--MD..AGKIKMPsmTY..KIF.CK..KVGI.E.LP 42 ...-..-------M.N...TV.EKLLAL.DAGR..LEMPNKE..VT..LKL.GK..LGGA.K.VT 43 ...M..AVKN--KF.V...SL.EDVLGK.NAEE..L--TAVT..LG..EID.AK..KLGG.K.LP 44 ...-..-------M.N...TV.EKLLN-.--MD..AGKLKMP..SStfELY.CK..KLDD.T.LE 45 ...M..AKKPVIKK.L...TL.ND-LMQ.QREK..YEVKQDT..KE..EVL.LR..RGDD.Q.VT 46 ...M..AEKKETNV.TvteDN.EMDLIT.GLLK..AAEYKTE..VQ..QPLnIT..RNGQtL.FK 47 ...-..-------M.N...TV.EKLLN-.--MD..AGKLKMP..SSifELY.CK..KLDD.I.LE 48 aeeM..VKVTKENE.L...DL.VQGLLE.-AAD..FRNDDDL..QT..EIQ.IK..RNDK.VfFK 49 ...-..--------.M...NL.VEQLLK.--ID..AGKIEVP..SK..EVK.LKlaKLGNmE.IT 50 ...-..-------M.D...TL.ELLLKG.ERPN..MPEKEIK..L-..KRL.SK..ACGG.D.II 51 ...-..-------MqL...TI.ENLLES.KGII..EGETGVK..TT..NLG.IK..RLGG.E.I- 52 ...-..--MNSTPK.S...AL.SEF-SR.RAIQ..RLQAKKI..PK..KQI.LH..IPSL.E.AD 53 ...M..NKETARK-.A...TL.ED-LIA.KATQ..KENDKKK..VK..EIS.TV..VNSE.E.VS 50 60 70 80 9 | | | | 1 FIFKAITTDRIDELEKENT...TYKNV.KGR........G....RVK.E..LDSQRFYARIAVET 2 FVFKPITTERIDELEKENT...TYKNI.KGR........G....RVK.D..LDTQRFYARIAIES 3 FIFKAITTDRIDELEKENT...TYKNV.KGR........G....RVK.E..LDSQRFYARIAVET 4 FILKPITTERIDELEKENT...TFKNV.KSR........G....RVK.D..LDSQRFYARIAIES 5 FVFKAITTERIDELEKENT...TFKNV.KGR........G....RVK.D..LDSQRFYARIAIES 6 WELKVLSSEEDEALRRKCT...KRVKV.IGNngkhtg..Q....YTS.E..IDYNSYVAELCVAS 7 WELKVLSSEEDEVLRRNCT...KRVKV.IGNngkptg..Q....FTS.E..IDYNSYVAELCVAS 8 WEFAPISPERDEELKSESTkrsMIMQG.KRK........G....QYNtD..FDHFKYQRLLTIES 9 WELKAIDSDRDRQLRKDST...IRVPV.LNKkgkatg..Q....YTS.E..TDFNTYTLKLCVET 10 WEFAPISPERDEELKSESTkrsMIMQG.KRK........G....QYNtD..FDHFKYQRLLTVES 11 LKFKPISADKGDELRKKCK...KITIV.KGQ........K....M-S.E..TDQDKFIANQIIET 12 WEIRALSSEEDAAIRKNCP...KREPI.LNKkgkht...G....QYN.Tv.TDYNKYYEELSIAC 13 WEIRSMTEAENEEIRKSAT...RKVKS.KNG........M....YTT.E..TNNELYLAKLAVAS 14 MKFKPISADKGDELRKKCK...KITIV.KGQ........K....M-S.E..TDQDKFIANQIIET 15 MKFKPISADKGDELRKKCK...KVKLV.KGQ........K....MI-.E..TDQDKFVSNQIIET 16 WELRPLMSEEDEALRRRFT...RMVQV.PGK........Ssq..FRQ.E..FDSNGYLAAMAAGC 17 MKFKPISADKGDELRKKCK...KVKLV.KGQ........K....MI-.E..TDQDKFVSNQIIET 18 WSIKPLTTRENDAIREDCT...MDVPV.TGK........Pnm..FRP.K..VNTSKYIAKMICAA 19 WKIRCMTEAENEEHRKAAT...KKVKA.KNG........T....YLS.E..TNSDLYLAKLAVGS 20 MRFKAIGATRADEIRRDCR...NVKFI.KSQ........K....IV-.E..TDQDKYLEKVIVET 21 WEFRHVSTKEDEDIRESCT...MDVQI.TGK........Pga..YRK.K..IDTNAYIAKLVAAS 22 MKFKPISAATGDEIRRSCR...KTTFH.KGQ........-....RLV.E..TDQDAFVAKLIIET 23 IKLKALTGKQISKIRKDNT...HSEKV.KGS........K....LEK.Dv.FDDENFNADIIEKA 24 FVFENVTSERLEELRKDCT...K-RIP.KGR........G....RQP.EekFDSDKFQALLALES 25 IKLKALTGKQISKIRKDNT...HSEKV.KGS........K....LEK.Dv.FDDENFNAEIIEKA 26 MRFRPISAEMGDMIRKRNR...KTKLI.KGQ........-....RIM.E..TDQDKYVSDLIIET 27 LTLKGLSEKEISKIRKECT...YNRKS.RGG........K....SED.K..LDGNEFDAGLIVAA 28 FEIRPITQEENKMLIKKYT...KRDK-.KGQ........E....Y--.-..FDRAEYISELTASA 29 FKIKSLTADEVSHIRKQAT...KRVLN.RKT........H....RYEqE..TDENQFQGLVVAEA 30 FKIKSLTADEVSELRKQAT...KRVLN.RKT........Hk...YEQ.D..TDENQFQDLVVAEA 31 VTLKGLSEKEINKIKRQCT...YTRKE.RGK........-....RIK.E..LDDEEFNAALIEAA 32 FKIKSLTADEVSDLRKQAT...KRVLN.RKT........Hk...YEQ.E..TDENQFQDLVVAEA 33 FTIKAMTSQEFEEIRKSAT...EIR--.--K........G....RKV.E..FDAQKFNLRAVINH 34 IDLKGLTEKEISGIREECT...TRRKI.NGK........-....IET.K..LNNADFDAALIIGA 35 FIIKRLSMKEIKEIRNNYK...TKEVY.RDKrng14gqvA....VIN.D..YDGDSAGLEIMVEA 36 VMCRALTISKDEEIQNTCL...KI---.-DE........N....MKT.D..IDLPEMQMLTIIEG 37 VELKGLNTVEIKKIREKCT...SKRKI.KG-........V....AEE.K..LNGEEYDAALIIGA 38 VTLKGLSEREIQRIRKECT...VERKH.RGN........-....RTK.E..LNEEEFNAALIESA 39 VMCRALTISKDEEIQNTCL...KI---.-DE........N....MKT.D..IDLPEMQMLTIIEG 40 FVIRSIDESLNDTLKKRAT...IKKKN.RQG........V....AIP.E..FNNDKYIDSLMSAC 41 FECTALEPETFDELQSSGL...KIE--.--N........G....SLK.D..LDNFKMKTNIILAS 42 FLCKAVSPEKMAKIQDN--...LIEIS.K-K........G....NIQ.G..TNMGKNKVLTVMEG 43 V--ASFDNKEFSQIKKDCT...TYVKSgKNG........R....MLP.E..IDEDKLMVEVIVAA 44 IECKAIDPERFDEIRMNSM...DV---.-NS........G....DVE.N..INIYELKVNTILES 45 ITIK----KPTRSLCLEC-...-ITLS.QDE........N....RQE.Q..AD-----INMVYNI 46 FNVRPLSFDEIAQCRKKAT...TYMAN.PGG........AslplVEK.E..VSTADYMAWKIYTA 47 IECNAIDPERFDEIRMNSM...DV---.-DS........G....NLE.N..INVYELKVNTILES 48 FKVRPLSEEELVKARRNAV...VKMPN.PSNpklp....P....IEK.D..LRVEEFTAWKIYYA 49 FKCNAISMERYNEIQERVL...QVDK-.--K........G....NIQ.G..FATAQAKIETVLAG 50 FRLRALSFNRVAEIKNS--...----H.AGG........D....ME-.-..-------VHILLAG 51 -TIQSLDPKKLEQILKEA-...----N.SGK........S....TL-.E..LN-----KKIIYMS 52 ITIRSLSYEEIVE----CT...NIDDS.ADK........N....R--.-..--SDKYC---IYLS 53 LTF----VKPSQSIVLDAM...E-EIG.EGD........D....I--.K..MVVQAFT-HLIYEC 0 100 110 120 | | | | 1 T...VYPT....FKA..KELR.....EA.YK.....TE.DPVEV.AKRV....LS..V..GGEYA 2 T...IYPD....FRS..KELR.....EA.YK.....TA.DPVEV.AKRV....LS..V..GGEYA 3 T...VYPT....FKA..KELR.....EA.YK.....TE.DPVEV.AKRV....LS..V..GGEYA 4 T...IYPD....FRS..KDLR.....EA.YK.....TA.DPVEV.AKRV....LS..V..GGEYA 5 T...IYPD....FRS..KELR.....EA.YS.....TQ.DPVEV.AKRV....LS..V..GGEYA 6 T...VFPD....LKD..AELQ.....NS.YG.....VM.GEAQL.LKTM....LT..-..AGEYV 7 T...VFPD....LKD..AELQ.....NS.YG.....VM.GEAQL.LKTM....LT..-..AGEYV 8 I...VYPN....LND..KELQ.....DS.YG.....VM.GADAL.LGKM....LT..I..-GEIA 9 V...VFPD....LHD..AELQ.....NS.YG.....VM.GAEEL.LTTM....LT..-..PGEYT 10 I...VYPN....LND..KELQ.....DS.YN.....VM.GADAL.LGKM....LT..I..-GEIA 11 T...VYPD....LKN..AELQ.....KA.WG.....VM.GAEQL.LKAM....KSkmS..DGEYM 12 T...VFPD....LND..SMLQ.....DS.YR.....VM.GANQL.LKAM....LT..-..PGEYT 13 V...VFPD....LKN..VELQ.....QS.YG.....TL.GAENL.LRRM....L-..L..PGEYA 14 T...VYPD....LKN..AELQ.....KA.WG.....VM.GAEQL.LKAM....KSkmS..DGEYM 15 T...IHPD....LKN..SELQ.....KA.WG.....VM.GAEEL.LNAM....KS..RmtDGEYA 16 T...VFPN....LND..KGLQ.....DS.YG.....VM.GAEAL.LKAM....LT..-..SGESA 17 T...IYPD....LKN..SELQ.....KA.WG.....VI.GAEEL.LSAM....KS..RmtDGEYA 18 V...IEPN....LND..KELQ.....DS.YG.....VM.TPEEL.LKEM....VD..D..PGEYG 19 V...VYPD....LKD..AELQ.....KS.YG.....TL.GAENL.LRVM....L-..L..PGEYA 20 T...VYPD....LKN..AELQ.....SN.WG.....VM.GAVEL.LQAM....KSkmT..DGEYS 21 C...VVPN....LNN..AELQ.....DS.YG.....VK.KPEDL.LKEL....VD..D..PGEYQ 22 T...TVPD....FKS..QELQ.....QS.WG.....VL.GAENL.LKAM....KTkmK..DGEYA 23 T...VSPN....WNN..EKLK.....AA.LS.....VS.NGKEV.IKRR....L-..L..AGEMD 24 T...VYPK....FSS..KELL.....NA.YK.....SP.SALEV.AKKV....LS..V..PGDYM 25 T...VSPN....WNN..EKLK.....AA.LN.....VS.NGKEV.IKRR....L-..L..AGEMD 26 T...TCPD....LKN..SELQ.....AS.WG.....VL.GAEEL.LSAM....KSkmR..DGEFS 27 T...TNFN....WND..SKLL.....DS.AK.....AS.DGKQF.IRKK....L-..L..AGEIS 28 V...VFPD....LTN..AELQ.....KA.YG.....VL.GASAL.LQKM....LY..V..-GEYA 29 V...VSPN....LNN..EKLQ.....TS.WG.....CIaKPEEV.LKKM....LK..V..-GEYT 30 V...VSPN....LNN..EELQ.....TS.WG.....CIaKPEKV.LKKM....LK..V..-GEYT 31 T...VTPN....WND..ERLL.....DA.LK.....AS.DGKQV.IRKK....F-..L..AGETS 32 V...VSPN....LNN..EKLQ.....TS.WG.....CIaKPEEV.LKKM....LK..V..-GEYT 33 T...IVPD....FKD..AASI.....QK.LG.....CR.TADEY.VQKV....L-..L..AGEMS 34 T...TNFN....WNN..PKLI.....EP.LK.....LS.DGKAY.IRKK....L-..L..AGEIS 35 F...VQPK....LDD..PELM.....EY.YG.....VH.DRLDM.PNII....FP..D..KDDFK 36 V...CDLDgkllFKN..KELM.....DK.FK.....AP.TPKEL.ARKL....L-..L..PGEIT 37 T...TNFD....WNN..PKLL.....EK.YS.....LS.DGKQF.ILRK....L-..L..AGERT 38 T...IKPN....WSD..KRLL.....SS.LS.....LS.SGREV.IKRR....L-..L..AGEMV 39 V...CDLDgkllFKN..KELM.....DK.FK.....AP.TPKEL.ARKL....L-..L..PGEIT 40 V...VTPD....LKD..AQLQ.....ES.YR.....TV.GDEAAtLKAM....LK..I..-GEYA 41 C...--KT....FKD..KELL.....KH.FK.....SP.TPREL.LRKM....L-..L..AGEIN 42 C...-SDT....FRN..KDLL.....EH.FN.....AP.TPKEL.INKL....L-..L..AGEID 43 VhndTRSDft..FRN..PQLL.....EK.LG.....VI.SAAEA.AGIL....LS..-..PGEIQ 44 C...--PI....FSN..MELV.....KK.FS.....AI.TPKEL.VKKL....L-..L..SGEID 45 V...VEPN....LKD..TNLH.....KA.YG.....CI.EPIEI.VEKI....FE..-..TGEIA 46 T...VATDgkkfWDN..SALK.....EG.LKkaghmVM.TQNEI.IKEV....LT..-..AGELE 47 C...--PM....FRN..MEVV.....EN.LG.....LA.TPKDL.LKKL....L-..L..AGEID 48 T...VDKEev..WDN..PSVMkgleaKG.FP.....VL.RGIDV.INTV....L-..R..AGEKD 49 V...--PE....LRS..EELM.....KH.FK.....AP.TPKEL.MNKI....F-..L..PGEVD 50 V...ISPD....LKS..EDLK.....QK.YN.....AV.TPLEM.IKTM....L-..L..PGEIE 51 V...IDPN....LKD..NELL.....KG.YG.....CKnNPYEI.VEKI....FT..I..T-EIG 52 V...VSPD....LKQaaKEIM.....ESeSG.....LPaDQRSL.LEPLdivdLF..D..MGEVT 53 C...--PM....LQN..ADLQ.....KG.LN.....VL.DPYDT.VPKL....FE..L..-GEIM 130 140 150 | | | 1 NWLNKAIEING.F...DD..DLE.....D.LEEA.A...KNLEHHHHHH... 2 NWLNKAIEING.F...ED..DLE.....D.LEEE.A...KN--------... 3 NWLNKAIEING.F...DD..DLE.....D.LEEA.A...KN--------... 4 NWLNKAIEING.F...ED..DLE.....D.LEEE.G...KKLVKDGDKEavy 5 NWLNKAIEING.F...ED..EIE.....D.LEEA.A...KN--------... 6 NYTVKVNEVNG.F...DT..SFE.....D.KVEE.A...KN--------... 7 NYTVKVNEVNG.F...DT..TFE.....D.KVEE.A...KN--------... 8 DASAVAQEVNG.Y...QA..ELE.....D.MVEE.I...KN--------... 9 DLSSEVGEVNG.F...DR..TFE.....D.KVEE.A...KN--------... 10 DASAVAQEVNG.Y...QA..ELE.....D.MVEE.I...KN--------... 11 GWGSVVSEING.Y...DK..GIQ.....E.LVEE.A...KN--------... 12 EYVQEVLDING.F...DN..SFE.....D.KVEE.A...KN--------... 13 NLIEKVQEING.F...DK..DIE.....D.LKEE.I...KN--------... 14 EWGSVVSEING.Y...DK..GIQ.....E.LVEE.G...KN--------... 15 DWSSTVIEING.Y...DK..GIQ.....E.LVEE.A...KN--------... 16 NYFQKAQEVCG.F...-T..PIE.....E.LTEQ.A...KN--------... 17 DWSSTVIEING.Y...DK..GMQ.....E.LVEE.A...KN--------... 18 DFANFVQQFNG.F...TT..TMD.....D.KVEE.A...KN--------... 19 ALIEKVQQING.F...DK..DLN.....E.LKEE.V...KN--------... 20 SWSNVVSEING.Y...DK..ELQ.....E.LIEE.A...KN--------... 21 DLFVFIQKYNG.F...DT..SME.....E.EVEE.A...KN--------... 22 TFSNIVSEVNG.Y...DK..SMN.....D.LVEE.A...KN--------... 23 DLINKIFDLSG.Y...ND..EAE.....D.-IED.I...KNSSGLDTNFi.. 24 NWISAASEANG.F...DD..EID.....D.EAES.IelaKN--------... 25 NLIEQVFDLSG.Y...ND..EAE.....D.-IEE.I...KNSLEPDTDSi.. 26 DWSSIVGEVNG.Y...DK..SVN.....D.LIEE.A...KN--------... 27 ALTDKILELSG.F...NN..ELE.....E.M-ED.I...KNS-------... 28 ELAQAVQELSG.L...DT..DIN.....E.DIEE.V...KNA-------... 29 ELSQAIMDLSG.Lnd.DD..SSE.....D.LVEE.A...KN--------... 30 ELSQAIMDLSG.Lnd.DD..SSE.....D.LVEE.A...KN--------... 31 AMGDKVLELSG.F...DN..ELE.....E.-IED.I...KN--------... 32 ELSQAIMDLSG.Lnd.DD..SSE.....D.LVEE.A...KN--------... 33 TIVSKIQELSG.F...DV..GMN.....E.LIDE.A...KN--------... 34 FLANKVLELSG.F...ND..ELE.....E.-KED.I...KN--------... 35 YADDCLMEACG.Las.KK..NDK.....E.TVEE.I...KKMMSGEGDDens 36 NLYRILQDVMG.Y...GK..NA-.....-.VIEE.V...KN--------... 37 NLVNKVLDLSG.Y...ND..ELS.....D.-AED.I...KNLSGEEE--... 38 ALGDKVMELSG.F...DN..EL-.....-.--EE.I...KN--------... 39 NLYRILQDVMG.Y...GK..NA-.....-.VIEE.V...KN--------... 40 TLMQEIQSLNG.F...DE..DIN.....D.LVEE.S...KKRLEDGDAElsy 41 DLYNKICELNG.YsesNS..EKD.....K.RIEEkI...KN--------... 42 ELYNTINELNG.Y...EQ..D-E.....E.EEEE.I...KNL-------... 43 RGAMEVQEISG.F...NT..GAE.....EeRAEE.V...KNS-------... 44 KLYEEVNKVNG.I...DA..EGDkkrqkE.RAKD.I...KN--------... 45 QISGYGMELAG.Y...GN..EMK.....-.AIKD.I...KN--------... 46 AVSDAIDNLSG.-...-G..GVS.....-.VVDY.A...KN--------... 47 NLYEEVNKVNG.I...DA..EGDkkrqkE.RAKD.I...KN--------... 48 AIDDQIDKISG.Fy..DS..EIS.....E.-EEY.A...KN--------... 49 ILADTVTEISG.V...ES..TNQ.....K.--ED.I...KNS-------... 50 DISREIEKLSG.Y...RV..T--.....-.TVEE.V...KKK-------... 51 IIADKIAKLNG.L...DDvkNLE.....D.FVVE.I...KN--------... 52 EIAMKVMELSGvL...NN..RKV.....T.VVEQ.L...KN--------... 53 KIGNQLSDLIG.L...NA..-VS.....D.TV--.-...KN--------...