Citations (SAM, SAM-T99, HMMs)
10 20 30 40 50 60 | | | | | | 1 MSEPVIKSLLDTDMYKITMHAAVFT.NFPDVTVTYKYTNRS.SQLTFNKEAINW...LKEQFSYL 2 -----ITSLLDTDLYKFTMMQVVLH.HFPAANVEYRFRCRT.PNVDL-VPYIGE...IRDEVRKL 3 -----IRSLLDTDLYKFTMMQVVLH.HFPQAQVEYRFKCRN.AGVDL-TPYVDE...IRSQITQL 4 -----ITSLLDTDLYKFTMMQVVLH.HFPAATVEYRFRCRT.RGVDL-VPYIDE...IRDEVRGL 5 -----ITSLLDTDLYKFTMMQVVLH.HFPAASVEYRFRCRT.PGVDL-VPYIDE...IRDEVRGL 6 ---MIIRSLLDTDLYKFTMMQVVLH.HFPGAHVEYRFKCRN.PGVDL-VPYIEA...IRAEIRHL 7 --EPVIKSLLDTDMYKITMHAAVFT.NFPDVTVTYKYTNRS.SQLTFNKEAINW...LKEQFSYL 8 -----IRSLLDTDLYKFTMMQVVLH.HFPGAHVEYRFKCRN.PGVDL-VPYIEA...IRAEIRHL 9 --SPVLHSLLDTDAYKLHMQQAVFH.HYYDVHVAAEFRCRG.DDLLG--IYADA...IREQIQAM 10 --SPVLHSLLDTDAYKLHMQQAVFH.HYYDVHVAAEFRCRG.DDLLG--IYADA...IREQIQAM 11 --SPVLHSLLDTDAYKLHMQQAVFH.HYYDVHVAAEFRCRG.DDLLG--IYADA...IREQVQAM 12 --SPVLHSLLDTDAYKLHMQQAVFH.HYYDVHVAAEFRCRG.DDLLG--IYADA...IREQVQAM 13 --SPVLHSLLDTDAYKLHMQQAVFH.HYYDVHVAAEFRCRG.DDLLG--IYADA...IREQVQAM 14 ----IITSLLDTDLYKFSMMQVVLH.HFPAAQVEYRYKCRT.PGINL-RPYLDE...IRAEVHEL 15 --ERIVQNLLDTDFYKLTMMQAVLH.NYPNAEVEWEFRCRN.AEDLR--PYLAE...IRYQIERL 16 ----IITSLLDTDLYKFSMMQVVLH.HFPAAQVEYRYKCRT.PGINL-RPYLDE...IRAEVHEL 17 --ERIVQNLLDTDFYKLTMMQAVLH.NYPNAEVEWEFRCRN.AEDLR--PYLAE...IRYQIERL 18 ----IITSLLDTDLYKFSMMQVVLH.HFPAAQVEYRYKCRT.PGVNL-RPYLDE...IRAEVHEL 19 -----IHSLLDTDLYKFTMMQAVLH.QHPAAQVDYRFKCRT.PGVDL-AQFIDE...ISREIDAL 20 ----IIKSLLDTDLYKFTMMQAVLH.QYPGAQVEYRFKCRT.PGVDL-ARFINE...ISHEIDGL 21 ----IIKSLLDTDLYKFTMMQAVLH.QYPGAQVEYRFKCRT.PGVDL-ARFINE...ISHEIDGL 22 ----IIKSLLDTDLYKFTMMQAVLH.QYPGAQVEYRFKCRT.PGVDL-ARFINE...ISHEIDGL 23 --NRIVQSLLDTDFYKLTMMQAVLH.NYPNVDVEWEFRCRN.GEDLR--PYLGE...IQHQIELL 24 -----IHSLLDTDLYKFTMMQAVLH.QHPAAQVDYRFKCRT.PGVDL-AQFIDE...ISREIDAL 25 ---PIIRSLLDTDLYKFTMLQVVLH.QFPAAHGEYEFRCRN.HPDTPLTQLKQQ...LETQLDLL 26 --SPVLHSLLDTDAYKLHMQQAVFH.HYYDVQVAAEFRCRG.DDLLG--IYADA...IREQVDAM 27 --SPVLHSLLDTDAYKLHMQQAVFH.HYYDVQVAAEFRCRG.DDLLG--IYADA...IREQVDAM 28 --NRIVQSLLDTDFYKLTMMQAVLH.NYPNVDVEWEFRCRN.GEDLR--PYLDE...IKHQIELL 29 ---PIIKSLLDTDAYKLHMQQAVYH.RYSHMPVVAEFRCRG.DELLG--EYATE...LRHQVNMM 30 --DRIVQNLLDTDFYKLTMMQAVLH.NYPNVEVEWEFRCRN.SEDLR--PYLAE...IRFQVERL 31 ---NPMVTPLLNDLYQFTMAYAYWKaGKQSERSVFDLYFRK.NPFGGEYTIFAG...LEECIKFL 32 ----IIHSLLDTDLYKFTMLQVVLH.QFPQTHSLYEFRCRN.ASTVYPLADIKEd..LEVELDAL 33 --TGIIHSLLDTDLYKFTMLQVVLH.QFPQTHSLYEFRCRN.ASTVYPLADIKEd..LEVELDAL 34 --EPIITSLLDNDLYKFTMLQAMLH.QFPQTHGVYRFRCRN.NKDAA-YPLADIkdaLEKQLDSL 35 ----IIHSLLDTDLYKFTMLQVVLH.QFPQTHSLYEFRCRN.ASTVYPLADIREd..LEAELDAL 36 --ERIVQNLLDTDFYKLTMMQAVLH.NYPNAEVEWEFRCRN.QEDLR--LYLPA...IREQLEYL 37 ---NSVVQPLLTDLYQITMAYAYWKsGKIDDHAVFDLFFRT.NPFQGEFTIFAG...LEECLKFL 38 ---NGVVQPLLTDLYQITMAYAYWKsDKTDDTAVFDLFFRN.NPFHGEFTIFAG...LEECLKFL 39 ---NPMVTPLLNDLYQFTMAYAYWKaGKHNERSVFDLYFRK.NPFGGEYTVFAG...LEECVKFL 40 ---PILTSLLDTDAYKLHMQQAVFH.HYRHITVAAEFRCRS.DELLG--VYADE...IRHQVTLM 41 ---PILTSLLDTDAYKLHMQQAVFH.HYRHITVAAEFRCRS.DELLG--VYADE...IRHQVTLM 42 ---NPMVTPLLTDLYQFTMAYAYWKaGKHLDRAVFDLYFRK.NPFGGEFTIFGG...LEECIRFI 43 -----IKSLLDTDMYKLTMHAAVYV.NFPDTEVVYKYTNRS.AGLSFNKAAIVW...LEDQVSKL 44 ---EGVISFLDTDLYKLTMQCAVFK.FFKDVPVTYAYTNRT.PDKKLSRTAFKW...LEEQIRKL 45 ---NPMVTPLLNDLYQFTMAYAYWKaGKHNERSVFDLYFRK.NPFGGEYTVFAG...LEECVKFL 46 -----LVQPLLTDFYQITMCYAYWKtGTHNEPAVFDVFFRK.NPFNGEFTVFAG...LEDCLRFV 47 ---EGVISFLDTDLYKLTMQCAVFK.FFKDVPVTYAYTNRT.PDKKLSRTAFKW...LEEQIGKL 48 ----GVISFLDTDLYKLTMQCAVLK.YFKDVPVTYSFTNRT.PEKKLSREAFVW...LEEQVMKL 49 ---NPMVTPLLNDLYQFTMAYAYWKaNKHQERAVFDLYFRK.NPFGGEYTVFSG...LEECIRFI 50 --ERIVHNLLDTDFYKLTMMQGVLH.NYPDADVEWEFRCRN.GEDLR--PYLGE...IRNQLERL 51 -----LVQPLLTDFYQITMCYAYWKtGTHNEPAVFDVFFRK.NPFQGEFTVFAG...LEDCLRFV 52 -----LVQPLLTDFYQITMCYAYWKtGTHNEPAVFDVFFRK.NPFQGEFTVFAG...LEDCLRFV 53 -----LVQPLLTDFYQITMCYAYWKtGTHNEPAVFDVFFRK.NPFQGEFTVFAG...LEDCLRFV 54 -----LVQPLLTDFYQITMCYAYWKtGTHNEPAVFDVFFRK.NPFQGEFTVFAG...LEDCLRFV 55 ---PIVKTLLDTDAYKLHMQQAVFY.HYKNVNVVAEFLCRG.DNFLG--CYANI...LLDQISMM 56 ---PVIKSFLDTDLYKLFMHAAVNK.QFPDVPVKYRYTNRT.PQLKLNSQAISW...LKKQIEYL 57 ---------LHTDAYQINMIQTYWNkGIHNKTAIFEVFFRN.MPFDNGYAVFAG...LDRIIDYI 58 ---------LHNDLYQINMAESYWNdNIHEKMAVFDLYFRK.MPFNSGYAVFNG...LKRVIDFI 59 ---------LHNDLYQINMAESYWNdNIHEKMAVFDLYFRK.MPFNSGYAVFNG...LKRVIDFI 60 ----PMATALLTDQYQFSMAYAYWKaGKHADRAVFDLYFRK.NPFGGEFTVFAG...LEECIKFI 61 ---------LHTDAYQINMIQTYWEqGIHNKHAVFEVFFRK.MPFRNGYAVFAG...LERVVNYI 62 ---------LHNDLYQINMAESYWNdNIHEKMAVFDLYFRK.MPFNSGYAVFNG...LKRVIDFI 63 ---------LHTDAYQINMIYTYWKqGIDQKPVVFEAYFRK.MPFNNGYVIFSG...LERIVKIL 64 ---------LHTDMYQINMMQTYWElGRADLHAVFECYFRE.MPFNHGYAIFAG...LERLVNYL 65 ----GFVTPLLTDLYQITMAYSLWKnNRHEIPAVFDLYFRK.SPFGGEFTVFAG...LEEVIRFV 66 ------------------MAYAYWKsGKIDDHAVFDLFFRT.NPFQGEFTIFAG...LEECLKFL 67 ---NSVVQPLLTDLYQITMAYAYWKsGKIDDHAVFDLFFRT.NPFQGEFTIFAG...LEECLKFL 68 ---------LHNDLYQINMAESYWNdNIHEKMAVFDLYFRK.MPFNSGYAVFNG...LKRVIDFI 69 ----PMATALLTDQYQFSMAYAYWKaGKHADRAVFDLYFRK.NPFGGEFTVFAG...LEECIKFI 70 --PDGVFSLLDTDLYKLTMQCAILK.YFPDVQVTYGFTNRT.PHMKLTRGAYKW...MLAQMDKL 71 ---------LHTDLYQINMMQTYWElGRADLHAVFECYFRE.MPFNHGYAVFAG...LERLVNYL 72 ---PIVKTLLDTDAYKFYMQQAVFY.HYKNVDVVAEFICRG.PNILG--CYSHI...LLDQINMM 73 --SRIIQSALDFDVYKVNMMSAVAA.LYPDAMVSYKFIVRS.EEDLS--ELLPE...VKAEVLKL 74 --------ILHTDLYEINMMYTYFKkGISERNSVFEVFFRK.EPFGNGYAVNAG...LSHVIQYL 75 ---------LLTDLYQLTMMQGYYQnGYENKEAVFDLYFRK.IPSGGGYVIAAG...LEQVVEYI 76 ---------LHTDLYQINMMQVYFDqGIHNKKAVFEVYFRQ.QPFKNGYAVFAG...LERIVNYL 77 ---------LHTDLYEINMMYTYFKkGISERNSVFEVFFRK.EPFGNGYAVNAG...LSHVIQYL 78 -LDPIIRSLLDTDFYKLLMLQMIWG.LYPRVDATFSLINRT.SSVRLADEIDEGe..LRAQLDHA 79 ---GIIDSLLDTDAYKLHMQQAIYH.QYPHVEAVAEFHCRS.KEDLR--PYAKA...IQAQIQHI 80 ---NGVVQPLLTDLYQITMAYAYWKsDKTDDTAVFDLFFRN.NPFHGEFTIFAG...LEECLKFL 81 ---------LHTDLYQINMMQVYFNkGIHNKRAVFEAYFRK.VPFENGYAVFAG...LERIVRYL 82 ---------LHTDLYQINMMQTYFElGRHQRQAVFEVFFRE.MPFKNGYAVFAG...LERMVDYL 83 --------PLLTDLYQATMALGYWRaGRARDAAEFELFFRR.CPFGGAFALAAG...LRDCVRFL 84 --------PLLTDLYQATMALGYWRaGRARDAAEFELFFRR.CPFGGAFALAAG...LRDCVRFL 85 ---------LHNDLYQINMAESYWNdGIHERIAVFDLYFRK.MPFNSGYAVFNG...LKRVVNFI 86 --------PLLTDLYQATMALGYWRaGRARDAAEFELFFRR.CPFGGAFALAAG...LRDCVRFL 87 -LDPIIRSLLDTDFYKLLMLQMIWG.LYPRVDATFSLINRT.SSVRLADEIDEGe..LRAQLDHA 88 ---------LHTDLYQINMMQVYFEqGIHNRHAVFEVYFRK.EPFNNGYAVFAG...LQRMVEYL 89 ---------LHTDLYQINMMQVYFEqGIHNRHAVFEVYFRK.EPFNNGYAVFAG...LQRMVEYL 90 ---------LHTDLYQINMMQVYFEqGIHNRHAVFEVYFRK.EPFNNGYAVFAG...LQRMVEYL 91 ---EGVISFLDTDLYKLTMQCAVLK.YYSNTSVTYSFTNRT.PEKRLSRKAYQW...LQDQIR-- 92 -LDPIVRSLIDTDFYKLLMLQMIWK.LYPEVDATFSLINRT.KTVRLAEEIDEMe..LREQLDHA 93 -LDPIVRSLIDTDFYKLLMLQMIWK.LYPEVDATFSLINRT.KTVRLAEEIDEMe..LREQLDHA 94 -LDPIIRSLLDTDFYKLLMVQMIWG.LYPNVNVTFSLINRS.KTIRLADDIDEMe..LRAQLDHA 95 ---------LHTDLYQINMAYTYWKdGIHNRRSVFDLYFRK.LPFENGYAVFAG...LEKIVEYI 96 -LDPIVRSLLDTDFYKLLMLQMIWG.MYPKVDATFSLINRT.TSVRLADEIDEGe..LREQLDHA 97 ---------LHTDLYQINMAYTYWKdGIHNRRSVFDLYFRK.LPFENGYAVFAG...LEKIVEYI 98 ---------LHTDLYQINMAYTYWKdGIHNRRSVFDLYFRK.LPFENGYAVFAG...LEKIVEYI 99 -LDPIVRSLLDTDFYKLLMLQMIWQ.LYPDVDATFSLINRT.KTVRLADEIDEQe..LRDQLDHA 100 ---------LHTDLYQINMAYTYWKdGIHNRRSVFDLYFRK.LPFENGYAVFAG...LEKIVEYI 101 -LDPIIRSLLDTDFYKLLMLQMIWG.LYPNVNVTFTLINRT.KTIRLADDIDEGe..LRAQLDHA 102 ---------LHTDLYQINMMQVYFNqGIHNKRAVFEVFFRK.EPFANGYAVFAG...LERMIAYL 103 ---NPMVTPLLTDLYQFTMAYAYWKaGKHLDRAVFDLYFRK.NPFGGEFTIFGG...LEECIRFI 104 ---------LHTDLYQINMAYTYWKdGIHNRRSVFDLYFRK.LPFENGYAVFAG...LEKIVEYI 105 ----MVVRPLLTDLYQATMALGYWRaGRACEAAEFELFFRH.CPFGGSFALSAG...LQDCMRFL 106 --EPVIKSLLDTDMYKITMHAAVFT.NFPDVTVTYKYTNRS.SQLTFNKEAINW...LKEQFSYL 107 -LDPICRSLLDTDFYKLLMLQMIWG.LYQDVDATFSLTNRN.HRVRLADEIDEAe..LRAQLDHA 108 ----------LTDFYELTMGNGYFEnGIGDRIAYFDMFFRR.VPENGGFAIMAG...LAQVIEYI 109 --PAIIQSVLDLDVYKINMMQAAYR.FYPQTQVRYELIVRS.DDNLS--DLVEE...VREEINRL 110 --PAIIQSVLDLDVYKINMMQAAYR.FYPQTQVRYELIVRS.DDNLS--DLVEE...VREEINRL 111 --EPAVVSILDTDLYKLTMLQAVLE.HYPDAQVSYKYTNRS.PKMALNQEAYNW...LREQIRGL 112 ---NPMVTPLLNDLYQFTMAYAYWKaGKQSERSVFDLYFRK.NPFGGEYTIFAG...LEECIKFL 113 -------RPLLTDLYQATMALGYWRaGRACEAAEFELFFRH.CPFGGSFALSAG...LQDCMRFL 114 -----------TDLYQATMALGYWRaGRAQDQAEFELFFRQ.CPFGGAFALAEG...LRDCVRFL 115 ------KSILDNDLYKFTMQMAVLE.LFPKAEAEYRFTNRG.SHHFSEEFVEKL...RRVIDEDI 116 ------KSILDNDLYKFTMQLAVLE.LFPKAEAEYRFTNRG.SQRFTTEFVEEL...ERTIREEI 117 ----------LADFYELTMANGYLKnNLGNKIAYFDMYFRR.VPDGGGYCVMAG...LQQLVEYL 118 --DPIIRSLLDTDFYKLLMLQMIRE.DYSNQQVTFSVINRS.RHVRLAEIIDEGe..LRAQLDHA 119 ---------LHTDLYQINMAETYWNdDVHNRKAVFDLYFRS.LPFGNGYGVYAG...LERIIEYM 120 ----MVVRPLLTDLYQATMGLGYWRaGRACEEAEFELFFRH.CPFGGSFALTAG...LQDCIRFL 121 ------KSILDNDLYKFTMQMAVLE.LFPKAEAEYRFTNRG.LQRFSREFVEEL...RRVIDEEI 122 ------------------MAYAYWRaGRHNEPAVFELFFRD.NPFGGGFSLFAG...LSDCLLFL 123 ---------MLVDFYELTMANGYFKnGIENKIAYFDMYFRR.VPDGGGYCIMAG...VEQLIEYL 124 ---------LHTDLYQINMAETYWRdGIHEKKAIFELFFRR.LPFENGYAVFAG...LEKAIEYL 125 -------SPLLTDLYQLTMMQGYFLsDLHRQQATFDLYFRR.LPFEGGYAVWAG...LEPMLDWL 126 -------SPLLTDLYQLTMLAGYLDeGMAETPAVFDLFFRH.NPFQGGYAVFAG...LDTALDFL 127 ---------LHTDLYQLNMMKAYFDdGLHERRSVFEVFFRD.MPFDSGFVVFAG...LERIIHYM 128 ---------LHTDLYQLNMMKAYFDdGLHERRSVFEVFFRD.MPFDSGFVVFAG...LERIINYM 129 ---------LHTDLYQLNMMKAYFDdGLHERRSVFEVFFRD.MPFDSGFVVFAG...LERIIHYM 130 ---------LHTDLYQLNMMKAYFDdGLHERRSVFEVFFRD.MPFDSGFVVFAG...LERIIHYM 131 -------------------ALGYWRaGRARDAAEFELFFRR.CPFGGAFALAAG...LRDCVRFL 132 -------------------ALGYWRaGRARDAAEFELFFRR.CPFGGAFALAAG...LRDCVRFL 133 ---------MLVDFYELTMGNGYLNkNVGNKTAYFDMFFRR.VPDNGGYCIMAG...VQQLTEYL 134 ----------LMDFYELTMANGYLLkGFGDKIVYFDVFYRK.NPDGAGFAIAAG...LQQIIDYI 135 -------SPLLTDLYQLTMLAGYLEeGMADKPAVFDIFFRH.NPFQGGYAVFAG...LDTALGYL 136 ----MVVRPLLTDLYQATMGLGYWRaGRACEEAEFELFFRH.CPFGGSFALTAG...LQDCIRFL 137 ---------LCTDLYELTMAQSYLY.EGKTGTAVFSLFVRK.LPEKRNFLISAG...LETLVERI 138 ----PIRSILDTDLYKLTMQQAVLR.HYPHTRVAYKFTNRSaATMKFTRQAMDR...IRNHIDNL 139 -IDPIVRSLIDTDFYKLLMCQSVFR.NRPDTVVRFSLINRT.SSVRLAELIDEGe..LREQLDHI 140 --------ALLCDFYEFTMSQGYFKnNKKDQICYFDIFFRK.IPDSGSFAIFAG...LEDILDFV 141 --------PLLNDFYQYTMAYSYYQaGFANRQATFEMFFRQ.NPFNGQYAVFAG...LRDLLDFI 142 -------SALFLDFYELTMAQGYFF.HKPHECAVFEVFFRK.HPFAGGYSIFAG...LDPLLTAI 143 ----------VTDLYELSMANGYQQ.ALEKEDGVFDVFFRH.VPDDGSFVITAG...LAQAIQAV 144 --PHIIRSLLDLDAYKINMMQAIHH.FYPDVSVRYELIVRS.EEDAS--GLLDA...IRQEIAHL 145 ---------LFTDFYEISMMNAYFT.KGINPKAKFEVFFRK.TPFKNGYIVLAG...MHTLINEL 146 -------NALFSDFYELTMAQGFWK.KGNNTKTVFEMFFRS.NPFKGGYSVFAG...LEPLLKTI 147 ---------LFTDFYELSMMNAYFT.KNINPKAKFEMFFRK.TPFKNGYIILAG...IHTLINIL 148 ------------------MAYAYWKsGKMEDKAVFDLFFRK.NPFKGEFAIFAG...LSECLKFL 149 ---------LLTDLYELSMANGFHH.DLPQTNATFDLFYRR.VPDNGSFVIAAG...LQQVVEAL 150 ---------LLTDLYQLTMIACYVGeKIDQRQASFELFVRK.LPTGFGYLIAMG...LAQALDYL 151 ----IIRSILDTDLYKFTTGYAYAK.LFPRAYGEFRFIDRN.RQGFT-EEFAEL...VRGEIRAM 152 -----VRTLLDTDLYKFTTSYAYIK.LFPYAMGTFSFNDRN.ETEYT-EEFLEA...LKSEFNKL 153 ------MNALFMDYYHLVMAYTFFRqKKHENISVFEVFFRK.CPFKGEFAVLGG...VHEVIKYI 154 ---------LLTDLYQLTMAACYTGeGVEQRRASFELFVRR.SPEGFGYLIAMG...LAQALEYL 155 ----NTINALFMDYYHLVMAYTYFKqNKHEDKSIFEVYFRK.CPFNGQFAILAG...VYEVIKYI 156 ---------LLTDLYQLTMAACYTGeGIEQRRASFELSVRR.LPEGFGYLIAMG...LTQALEYL 157 -----------TDQYQLAMGQVYFLkGKKNHPAVFDYFFRK.LPFGGGYAIFAG...LEDLLAIL 158 --------ALLTDLYQLTMLQGYVE.RDMLDGAVFEFFARK.PPACRNFYLAAG...LEQVLDYL 159 ----------------------VLE.LFPNARAEYRFINRG.AQSFTNDFVNEL...RRIINKDI 160 ------ESSLLTDLYQLTMAACYAGeGIAEKKASFELFVRR.LPDNFGYLIAMG...LAQGLQYL 161 ------VGALFTDLYEVTMAQAYWA.ERMSGTAVFEIFFRK.LPPGRSYIMAAG...LADVVEFL 162 ---------LMTDMYEYTMLDAALKdGTADRKCVFEVFTRH.LPEGRRYGVVAG...TGRILDAL 163 --------VINSDRYQYTESDIFLMeNMQNKIAVFDMFFRK.TEDGG-FAVVSG...IQEVIHLI 164 --------ALMTDMYEYTMLDAALKdGTADRKCVFEVFTRH.LPEGRRYGVVAG...TGRILDAL 165 ---------LLTDLYELTMVSTYAGeDLAWTPASFELSVRR.LPRGYTYLVAMG...LAQVLEYL 166 ------------------MAYAHWRaGRAQQPAVFELFFRE.NPFGGGFTLLAG...LHDCLRFL 167 -------TALLTDKYELTMLQAALAdGSAERPSTFEVFSRR.LPNERRYGVVAG...TARVLKAI 168 ----ERSTALLTDKYELTMLQAALAdGTADRQVTFEVFSRR.LPNERRYGVVAG...TARVLHAV 169 --PPILNSLLDTDAYKLHMQQAVFH.RYPDAEVVAEFHSRN.EEDLL--PMMGQ...IEEQLHLA 170 -------RVINSDRYQYTESDIFLMeNMQNKVAVFDMFFRK.TEDGG-FAVVSG...VQEVIHLI 171 --------ALLTDMYELTMLQSALAdGTAERQCTFEVFGRR.LPNERRYGVVAG...TPRVLEAV 172 -------------------------.---------------.------------...-------- 173 -----LVQPLLTDFYQITMCYAYWKtGTHNEPAVFDVFFRK.NPFQGEFTVFAG...LEDCLRFV 174 -------------------------.---------------.------------...-------- 175 -------------------------.---------------.------------...-------- 176 -------------------------.---------------.------------...-------- 177 -------------------------.---------------.------------...-------- 178 -------------------------.---------------.------------...-------- 179 -------------------------.---------------.------------...-------- 180 -------------------------.---------------.------------...-------- 181 -------------------------.---------------.------------...-------- 182 -LDPIVRSLLDTDFYKLLMLQMIWQ.LYPDVDATFSLINRT.KTVRLADEIDEQe..LRDQLDHA 70 80 90 100 11 | | | | 1 GNLRF.....TEEEIEYLKQEIPY.....LP..SAYIKYISSSNYKLHPEEQISFTSEE..I..E 2 CQLRF.....TDDELDYLRR-MRF.....IK..GDFIEFLALFHLNE---KYISIGPSP..K..G 3 CQLRF.....TDDELNYLRG-LRF.....IK..SDFVEFLALFHLNE---KYVQVLPSA..K..G 4 CALRF.....TDVELDYLRR-MRF.....IK..SDFVDFLALFHLNE---KYISIMPSP..K..G 5 CALRF.....SDVELDYLRR-MRF.....IK..SDFVDFLALFHLNE---KYISITPSP..K..G 6 CSLRF.....TEAELDYLRG-LRF.....IK..SDFVDFLDLFHLSE---KYIDIRPAA..S..N 7 GNLRF.....TEEEIEYLKQEIPY.....LP..SAYIKYISSSNYKLHPEEQISFTSEE..I..E 8 CSLRF.....TEAELDYLRG-LRF.....IK..SDFVDFLDLFHLSE---KYIDIRPAA..S..N 9 QHLRL.....QDDEYQWLSA-LPF.....FK..ADYLNWLREFRFNP------EQVTVS..N..D 10 QHLRL.....QDDEYQWLSA-LPF.....FK..ADYLNWLREFRFNP------EQVTVS..N..D 11 QHLRL.....QDDEYQWLSA-LPF.....FK..ADYLNWLREFRFNP------EQVTVS..N..D 12 QHLRL.....QDDEYQWLSA-LPF.....FK..ADYLNWLREFRFNP------EQVTVS..N..D 13 QHLRL.....QDDEYQWLSA-LPF.....FK..ADYLNWLREFRFNP------EQVTVS..N..D 14 CQLRF.....TSEELDYLRG-LRF.....IK..SDFVDFLGLFHLPE------RCIFIG..E..G 15 AEVEV.....TADQLAFLER-IPF.....MK..PDFIRFLSLFRFNL------RYVHTG..I..E 16 CQLRF.....TSEELDYLRG-LRF.....IK..SDFVDFLGLFHLPE------RCIFIG..E..G 17 AEVEV.....TADQLAFLER-IPF.....MK..PDFIRFLSLFRFNL------RYVHTG..I..E 18 CQLRF.....TSEELDYLRG-LRF.....IK..SDFVDFLGLFHLPE------RCIFIG..E..G 19 CRLRL.....REDEVDYLRS-LRF.....IK..PDFADFLALFHLDR------KYLSLT..A..S 20 CGLCF.....SKEELDYLRG-LRF.....MK..PDFVDFLGLFHLDR------KYLQLR..A..S 21 CALCF.....SKEELDYLRG-LRF.....MK..PDFVDFLGLFHLDR------KYLQLR..A..S 22 CALRF.....SKEELDYLRG-LRF.....MK..PDFVDFLGLFHLDR------KYLQLR..A..S 23 CELSL.....SPEHLVFLER-ITF.....MK..PDFLRFLGLFRFNT------RYVKTS..I..E 24 CRLRL.....REDEVDYLRS-LRF.....IK..PDFADFLALFHLDR------KYLALA..A..S 25 CELRF.....SQDELDYLRG-LRF.....IK..SDYVDYLELFHLQR------RFISVS..E..E 26 QHLRL.....LEDEFQWLSG-LPF.....FK..PDYLNWLREFRYNP------AQVCVT..N..D 27 QHLRL.....QEDEFQWLSG-LPF.....FK..PDYLNWLREFRYNP------AQVCVT..N..D 28 CELSL.....SPEHLAFLER-ITF.....IK..PDFLRFLGLFRFNT------RYVKTT..I..E 29 ADLAL.....TDAEFNYLSS-LPF.....FK..ADYLDWLKTFRFNP------QQVNIS..V..T 30 AELSL.....SADQLSFLER-ISF.....LK..PDFLRFLGLFRFNL------RYLHTG..I..E 31 ANFNL.....TDEEIDFVRDSLPG.....CE..EAFCDYLRGLDCSD-----IEVYAIS..E..G 32 CQLRF.....THDELDYLRS-LRF.....IK..SDFVDYLELFQLQR------RFVEVG..T..D 33 CQLRF.....THDELDYLRS-LRF.....IK..SDFVDYLELFQLQR------RFVEVG..T..D 34 CELRF.....LEDELEYLRG-LRF.....MR..SDFVDYLELFKLKR------RFITVT..T..D 35 CQLRF.....THDELGYLRS-LRF.....IK..SDFVDYLELFQLQR------RFVEIG..T..D 36 AGLAI.....SDEQLAFLER-IPF.....LA..PDFIRFLGLFRFNP------RYVQTG..I..E 37 DSFHY.....SETDIEYLKHALPQg....IE..DEFFEYLSQLTAKD-----VTLYAIE..E..G 38 DSFHY.....SQSDIEYLKQTLPEg....IE..HEFFEYLGNLTARD-----VTLYAID..E..G 39 ANFKL.....TDEEIDFVQECLPG.....SE..EAFCDYLRGLDCSD-----VEVYAIP..E..G 40 GQLAL.....TSDEFIYLSS-LPF.....FQ..DDYLHWLRDFRFKP------EQVSVA..V..H 41 GQLAL.....TSDEFIYLSS-LPF.....FQ..DDYLHWLRDFRFKP------EQVSVA..V..H 42 ANFKL.....TDTEITFLRSAMPT.....CE..DGFFEYLSSIDCSD-----VEVYAIP..E..G 43 ATLRF.....TAEEVAYLKETLPF.....LP..AQYIDYISSPECRMDPATQVQLLHEQ..R..E 44 GNISL.....STDEYLFLKKHCDY.....LS..DDYLNFLKEFRLSPREQVVATFTPVG..EdnG 45 ANFKL.....TDEEIDFVQECLPG.....SE..EAFCDYLRGLDCSD-----VEVYAIP..E..G 46 ENFKF.....SQSDIEYVKKILPEn....AD..DSFFEYLETLDGSR-----LTIEAVS..E..G 47 GNISL.....STDEYLFLKKHCDY.....LS..EDYLNFLKEFRLSPREQVVATFTPVG..EdtG 48 GNISL.....SPEELQFLKTHCPY.....LT..EEYLDYLSEFRLRPREQVAVSFRPDG..D..S 49 ANFKL.....SEDEIDFVRQSLSPs....CE..DAFFDYLRGLDCSD-----VEVYAIP..E..G 50 ADLTL.....DDGQLAFLER-ISF.....LK..PDFLRFLRLFRFNL------RYVHVG..I..E 51 ENFKF.....SQSDIDYVKKILPEn....AE..PEFYEYLETLNGSH-----LTIEAVA..E..G 52 ENFKF.....SQSDIDYVKKILPEn....AE..PEFYEYLETLNGSH-----LTIEAVA..E..G 53 ENFKF.....SQSDIDYVKKILPEn....AE..PEFYEYLETLNGSH-----LTIEAVA..E..G 54 ENFKF.....SQSDIDYVKKILPEn....AE..PEFYEYLETLNGSH-----LTIEAVA..E..G 55 RSLSL.....SHEEYVYMTS-FPF.....FK..KEYLHWLKKFRYNV------SQVKIN..S..Y 56 GDLRF.....SAEEILYLHRVLPQ.....LP..SDYLEYLADFKLVP--SSQIKYLDND..E..- 57 SNLHF.....SESDIEYLKD-VAG.....YP..DDFLAYLKDFHFRG------TIRSAV..E..G 58 EHFGF.....SESDLEYLKS--IG.....YK..DDFLSYLKDLKFTG------SIRSMQ..E..G 59 EHFGF.....SESDLEYLKS--IG.....YK..DDFLSYLKDLKFTG------SIRSMQ..E..G 60 ANFKF.....TEDDILFLQSVMPM.....CE..DAFFDYLRKTDCSD-----VEVYSIP..E..G 61 NHLHF.....TATDIAYLRE-LGG.....YS..DGFLDYLANFKFDA------TIRAVR..E..G 62 EHFGF.....SKSDLEYLKS--IG.....YK..DDFLSYLKDLKFTG------SIRSMQ..E..G 63 NQLKF.....TDDDIDYLQS-LDL.....YD..TEFLTYLKNWHLTA------TIRSAY..E..G 64 ENLTF.....TESDIAYLRE-VEE.....YP..EDFLTYLANFEFKC------TVRSAL..E..G 65 SDFHY.....TKEEVGFIKEMIPD.....CE..QEFLDYLSKLDSSS-----VTLYAMK..E..G 66 DSFHY.....SETDIEYLKHALPQg....IE..DEFFEYLSQLTAKD-----VTLYAIE..E..G 67 DSFHY.....SETDIEYLKHALPQg....IE..DEFFEYLSQLTAKD-----VTLYAIE..E..G 68 EHFGF.....SESDLEYLKS--IG.....YK..DDFLSYLKDLKFTG------SIRSMQ..E..G 69 ANFKF.....TEDDILFLQSVMPM.....CE..DAFFDYLRKTDCSD-----VEVYSIP..E..G 70 ANIRV.....TEDEIAFLKRRCPY.....FN..TAYLDFLTNFRLKPSEQIDINFTPVN..Dt.G 71 ENLTF.....NDSDIAYLRG-LEV.....YP..EGFLEYLQNFEFKA------TVRSAR..E..G 72 SSLSL.....SHEEYLYMTT-FPF.....FK..KEYLHWLKKFRYNI------TQVKVD..N..Y 73 QDVRF.....TEDEIAYMKRVAPY.....LK..PEFVEALRHFRFNPQSDVSFHNKTMS..D..G 74 NNLHF.....KESDLKYLKE-TCG.....YD..DEFIDYLRNLKLKL------TIRSAR..E..G 75 ENLRF.....SSEDMAYLRG-LNI.....FD..EGFLNLLKDFRFHG------DIDAVP..E..G 76 EDLRF.....SDSDIAYLES--LG.....YH..GAFLDYLRNFKLEL------TVRSAQ..E..G 77 NNLRF.....NESDLEYLKE-TCD.....YD..DDFIDYLRNLELRL------TIRSAR..E..G 78 RTLRF.....SKKEMIWLAGNTFYgrkqiFQ..PEFLAWLHDFQLPEYELRRKD-----..-..- 79 STLSF.....AQEELDYLAS-LSF.....FK..KDYLTYLKDFSLNS------EQVTVD..G..S 80 DSFHY.....SQSDIEYLKQTLPEg....IE..HEFFEYLGNLTARD-----VTLYAID..E..G 81 ENLSF.....SDSDLSYLEE--LG.....YP..EEFLDYLKNLKMEL------TVKSAK..E..G 82 KNLKF.....SETDIAYLRE--LD.....YP..EDFLNYLKELRFTG------TVRAMQ..E..G 83 RAFRL.....RDADVQFLASVLPPd....TD..PAFFEHLRALDCSE-----VTVRALP..E..G 84 RAFRL.....RDADVQFLASVLPPd....TD..PAFFEHLRALDCSE-----VTVRALP..E..G 85 ENFGF.....TNEDITYLKS--IG.....YE..EDFLNYLKDLKFTG------NIKSMQ..E..G 86 RAFRL.....RDADVQFLASVLPPd....TD..PAFFEHLRALDCSE-----VTVRALP..E..G 87 RTLRF.....SKKEMIWLAGNTFYgrkqiFQ..PEFLAWLHDCQLPEYELRRKD-----..-..- 88 EQFQF.....SETDLAYLEE--LG.....YP..ENFLTYLKELRLEL------TIRSAK..E..G 89 EQFQF.....SETDLAYLEE--LG.....YP..ENFLTYLKELRLEL------TIRSAK..E..G 90 EQFQF.....SETDLAYLEE--LG.....YP..ENFLTYLKELRLEL------TIRSAK..E..G 91 -----.....-NEEYRFLKDNCPY.....LG..TQYLEFLQNFRLNPRDQVIVSFAPVGkhE..G 92 RTLRL.....SKKENIWLAGNTFYgrsqiFE..PEFLSWLSSYQLPEYELFKRD-----..-..- 93 RTLRL.....SKKENIWLAGNTFYgrsqiFE..PEFLSWLSSYQLPEYELFKRD-----..-..- 94 LNLRF.....TKKEMIWLAGNTFYgrkqiFE..PDFLQWLENFQLPEYELTRKD-----..-..- 95 ENFSF.....TESDIAYLAE--LQ.....FE..EEFLQYLQNMKFTG------TIRSMQ..E..G 96 RTLRF.....SKKEMIWLGGNNFYgrkqiFE..PEFLAWLEGFRLPDYELSKRD-----..-..- 97 ENFSF.....TESDIAYLAE--LQ.....FE..EEFLHYLQNMKFTG------TVRSMQ..E..G 98 ENFSF.....TESDIAYLAE--LQ.....FE..EEFLHYLQNMKFTG------TIRSMQ..E..G 99 RGLRF.....TKKEMIWLAGNSFYgrtqiFS..PEFLAWLARFRLPEYELSRRD-----..-..- 100 ENFSF.....TESDIAYLAE--LQ.....FE..EEFLHYLQNMKFTG------TVRSMQ..E..G 101 LSLRF.....TKKEMIWLAGNTFYgrkqiFK..PDFLHWLKNFQLPEYELTRKD-----..-..- 102 QGLSF.....SETDIAYLEE--LG.....YP..ADFVAYLKEFKLEL------SVKSAK..E..G 103 ANFKL.....TDTEITFLRSAMPT.....CE..DGFFEYLSSIDCSD-----VEVYAIP..E..G 104 ENFSF.....TESDIAYLAE--LQ.....FE..EEFLHYLQNMKFTG------TVRSMQ..E..G 105 RAFRL.....RDADVQFLASVLPPd....TD..PAFFEHLRALDCSG-----VTVRALP..E..G 106 GNLRF.....TEEEIEYLKQEIPY.....LP..SAYIKYISSSNYKLHPEEQISFTSEE..I..E 107 RTIRF.....SKKEMIWLAGNSFYgrkqiFS..PEFLAWLADFQLPEYELRRRD-----..-..- 108 NNLKF.....EDDDIEFLRS-KGI.....FS..EDFLKYLKDFKFCC------DIWAIP..E..G 109 AELRF.....DAAQLAYLAEKAPY.....LT..AEFLSYLETFRFHPQQQVSVGIFRTA..Q..G 110 AELRF.....DAAQLAYLAEKAPY.....LT..AEFLSYLETFRFHPQQQVSVGIFRTA..Q..G 111 RNLHL.....LPEEEQWLRKNCPY.....LK..ESFYEFMHEFEFDPENSISLNYDSE-..-..- 112 ANFNL.....TDEEINFVRDSLPG.....CE..EAFCDYLRGLDCSD-----IEVYAIS..E..G 113 RAFRL.....RDADVQFLASVLPPd....TD..PAFFEHLRALDCSG-----VTVRALP..E..G 114 RAFRL.....RDADVQFLASALPPd....TD..PAFFEHLRALDCSG-----VTVRALP..E..G 115 SALML.....TEDEYQWLGENCSF.....LK..PMYLEYLKNFRFKPGEV---EVCLTE..-..- 116 SKLAL.....TEEEYNWLSENCPY.....LK..PMYLEYLKNFRFKPGEV---KVCLTE..-..- 117 SNLTF.....SEDDINFLRS-KSI.....FC..EEFLDYLKNFNFTC------DVWAIP..E..G 118 RTIRF.....TKKELIWLAGNTFYgkthmFS..ADFIRWLAEFRLPEYELRKVE-----..-..- 119 NNFRF.....TDADLTYLKE--IG.....YQ..DDFIEYLKSIRFTG------TIKSMK..E..G 120 RAFRL.....RDADVQFLASVLPPd....TD..PAFFEHLRALDCSR-----VSVRALP..E..G 121 SGLRL.....TEEEYRWLGEKCPF.....LK..PMYLEYLKNFRFKP---EEVEICLTR..E..- 122 QNFSF.....SDDDVQYLRSVLPAd....TD..AGFFSYLKELDCSC-----VSVSAVP..E..G 123 SNLNF.....SEDDIAYLRS-KEL.....FC..DEFLDFLINFKFTC------DVWAIP..E..G 124 ENFKF.....TDSDLSYLQD-ELG.....YH..EDFIEYLRGLSFTG------SLYSMK..E..G 125 QGLHF.....AEADLDYLAS-LGQ.....FR..PEFLAALREWRFSC------EVTAFP..E..G 126 EHLEF.....SEDEIEYLQG-LGL.....FR..PAFIDFLRSFRFRG------RVTAPP..E..G 127 QNLRF.....TETDIAYLHD-ELG.....FD..GPFLEYLRNFKFKG------NILAAK..E..G 128 QNLRF.....TETDIAYLHD-ELG.....FD..GPFLEYLRNFKFKG------NILAAK..E..G 129 QNLRF.....TETDISYLHD-ELG.....FD..GPFLEYLRNFKFKG------NILAAK..E..G 130 QNLRF.....TETDIAYLHD-ELG.....FE..GPFLEYLRNFKFKG------NILAAK..E..G 131 RAFRL.....RDADVQFLASVLPPd....TD..PAFFEHLRALDCSE-----VTVRALP..E..G 132 RAFRL.....RDADVQFLASVLPPd....TD..PAFFEHLRALDCSE-----VTVRALP..E..G 133 SNLRF.....TKEDIDYLRS-KHE.....FS..EEFLSYLKDFKFEC------DVWAVP..E..G 134 KNLKF.....SEEDIEYLKE-KNM.....FS..EDFLKYMKNFRFSG------SINAIP..E..G 135 ENLQF.....TEDDLEYLQG-LEI.....FR..PRFIDFLRSFRFRG------KVTAPP..E..G 136 RAFRLrd7stTSTDVQFLASVLPPd....TD..PAFFEHLRALDCSR-----VSVRALP..E..G 137 KNFKF.....GDEEIKYLKS-LGI.....FK..DDFLDYLKDFEFSG------NVYAIP..E..G 138 VHLSL.....SAQERAWLERSCPY.....LG..KDYLDYLEAFRFQPKQQVQLRFLPTG..E..D 139 RTLSL.....SRGESTFLRGNTFYgkrqmFR..PDFMEWFENLRMPPYHLEKRD-----..-..- 140 ENLSF.....DAEDIEFLRK-QGI.....FD..TEFLDFLANFKFKG------EIYAMR..E..G 141 LDFRF.....SDDDISYLKLCLPD.....LD..PGFFDYLKTLSWRQ-----LELYAPK..E..G 142 EQFRF.....SGEDIDYLRT-LHL.....FH..DDFLSYLASFRFSG------DIHALE..E..G 143 SDFHF.....DEKDLAYLKN-LDL.....FT..DNFLNFLKKFKFSG------NISAIP..E..G 144 GTLRF.....SDADIHYLTQHAPH.....LK..ATFLQSLRYFHFVPQEQV--EMGIVK..Q..G 145 KNIRF.....GENELKYLKS-FNI.....LD..KQFLNFLREFKLNV------KISSIE..E..G 146 QNFHF.....EKSDIDWLKS-LGI.....FE..KDFLEYIAGFKFSG------NIWAMK..E..G 147 KNLHF.....RKEEIEYLES-LEY.....FD..QKIFRILKDHFLNI------KISSIE..E..G 148 SNFRF.....SDSDINYLKQILPH.....VD..PQFWEYLSGLDASQ-----VTMSAIP..E..G 149 QDFHF.....TNSDLDYFRQ-LNL.....WD..ESFLAMLANFKLTC------QIKALP..E..G 150 EKFRF.....SSEQIDALKSTGIFan...AP..SEFWSLLAEAKFTG------NVWAVK..E..G 151 AALSL.....TRDEKEFLQRELPY.....LP..PIYIDFLDGFRFDP------EEVTVS..I..D 152 SRLRL.....TEEELEYMTRNCRF.....LP..RVYWEWLSSFRFDP------DKIDIH..L..D 153 NCFRF.....TQRQLEYIKKKMSHye...YI..DEFVDYLKGVNGSR-----LSIHSME..E..G 154 EKLRF.....SPEQIAALQATGIFah...AG..EGFWSLLAEGRFTG------DVWAVP..E..G 155 NCFRF.....TKAQLDFIRKKMSS.....YNdiDSFVQYLEKISGND-----LCIYGME..E..G 156 AKIRF.....SSAQIAALQATGIFah...AG..DRFWSLLAEGKFTG------DVWAVP..E..G 157 ENLRF.....NEKDIEFLHR--QG.....FH..PEFLNYLRDFRFTG------TLYASR..E..G 158 EQLHF.....TQGELDWLSG-LGL.....FR..PAFLDYLAGLRFSG------EVQAMA..E..G 159 SKIAL.....SEDEYIWLKDNCPF.....FK..PSYIEYLKNFRFNPEEVKIV-----L..T..E 160 ENLRF.....SAEQIDYLQSTGIFdh...VT..PYFWSLLQNQGFTG------DVWAVP..E..G 161 EAFRF.....DEQDLRYLRG-LGQ.....FS..DEFLRWLAGVRFTG------DVWAAP..E..G 162 EHFHL.....DEADLKFLAD-RHV.....VS..PETIKWLENFHFSG------TIRGYR..E..G 163 EVLNT.....TSEEEKRKYFSKIL.....EE..EHLINFLAKMKFTG------DLYAIQ..D..G 164 EHFHL.....DEADLKFLAD-RHV.....VS..PETIKWLENFHFSG------TIRGYR..E..G 165 QQLRL.....TPQQIDYLRGLAVFer...AP..AAFWELLSQGEFRG------DVWAVP..E..G 166 RGFRF.....SEDDVEFLRSVMPPt....TD..PAFFQFLLQLDASR-----VTLRSVP..E..G 167 RDFVF.....TEEQLAD----LDF.....LD..DRTLEYLRNYRFTG------QVDGYR..E..G 168 KDFTF.....TDEQLADL----DF.....LD..QRTRDFLASYRFTG------QIDGYR..E..G 169 GSLRL.....TRPELNFLAE-RPF.....FT..ADYLDHLRRKPLDA------SLLKVF..E..Q 170 EVLNT.....TSEEEKKKYFSKIL.....EE..EHLINFLSKMKFTG------DLYAIQ..D..G 171 QNFRF.....TEAQLAS----LTF.....LN..DTTLEYLRNYRFAG------HIDGYR..E..G 172 -----.....--------------.....--..--------------------------..-..- 173 ENFKF.....SQSDIDYVKKILPEn....AE..PEFYEYLETLNGSH-----LTIEAVA..E..G 174 -----.....--------------.....--..--------------------------..-..- 175 -----.....--------------.....--..--------------------------..-..- 176 -----.....--------------.....--..--------------------------..-..- 177 -----.....--------------.....--..----SLLESHNVDV--HAIPEGTVLK..A..R 178 -----.....--------------.....--..--------------------------..-..- 179 -----.....--------------.....--..--------------LRDKKIDVYAIP..E..G 180 -----.....--------------.....--..--------------------------..-..- 181 -----.....--------------.....--..--------------------------..-..- 182 RGLRF.....TKKEMIWLAGNSFYgrtqiFS..PEFLAWLARFRLPEYELSRRD-----..-..- 0 120 130 140 150 160 | | | | | | 1 GKPTHYK.....LKILVSGSWKDTILYEIPLLSLISEAYFK.....FVDIDWDYENQLEQAEKKA 2 N----GE.....IDIEIKGPWLHTILFEIPMLAIVNEVYFR.....NTQQKPDYSEGRGRLVEKI 3 N----GE.....IEIIIKGPWLHTILFEIPLLAIVNEVYFR.....RTQPKPDLAEGRRRLQAKL 4 N----GE.....IDIVIEGPWLHTILFEIPVLAIVNEVYFR.....NTQREPDYREGRERLRDKI 5 N----GE.....IDIEIIGPWLHTILFEIPVLAIVNEVYFR.....NTQREPDYREGRERLCEKI 6 D----GQ.....IDIVISGPWLHTIMFEVPVLAIVNEVYFS.....RTQAHPQWDEGKRRLTEKL 7 GKPTHYK.....LKILVSGSWKDTILYEIPLLSLISEAYFK.....FVDIDWDYENQLEQAEKKA 8 D----GQ.....IDIVISGPWLHTIMFEVPVLAIVNEVYFS.....RTQAHPQWDEGKRRLTEKL 9 N----GK.....LDIRLSGPWREVILWEVPLLAVISEMVHR.....YRSPQADVAQALDTLESKL 10 N----GK.....LDIRLSGPWREVILWEVPLLAVISEMVHR.....YRSPQADVAQALDTLESKL 11 N----GK.....LDIRLSGPWREVILWEVPLLAVISEMVHR.....YRSPQADVAQALDTLESKL 12 N----GK.....LDIRLSGPWREVILWEVPLLAVISEMVHR.....YRSPQADVAQALDTLENKL 13 N----GK.....LDIRLSGPWREVILWEVPLLAVISEMVHR.....YRSPQADVAQALDTLESKL 14 E--QPGE.....ISITVKGPWLHTILFEIPVLAIVNEVYFR.....NTRRNPDWEEGRKRLQSKM 15 D----GQ.....LAIRLRGPWLHVILFEVPLLAIVSEVRNR.....YRYREVVLEQVGEQLYRKL 16 E--QPGE.....ISITVKGPWLHTILFEIPVLAIVNEVYFR.....NTRRNPDWEEGRKRLQSKM 17 D----GQ.....LAIRLRGPWLHVILFEVPLLAIVSEVRNR.....YRYREVVLEQVGEQLYRKL 18 E--QPGE.....ISITVKGPWLHTILFEIPVLAIVNEVYFR.....NTRRNPDWEEGRKRLQSKM 19 A-THPGE.....IELTIRGPWLHTILFEVPLLAIINEVWFR.....NTS-EPDFEEGRSRLREKV 20 S-QVPGE.....IELDIRGPWLHTILFEVPLLAIINEVWFR.....NTSVL-NLDVGRDRLDAKV 21 S-QVPGE.....IELDIRGPWLHTILFEVPLLAIINEVWFR.....NTSVL-NLDVGRDRLDAKV 22 T-QVSGE.....IELDIRGPWLHTILFEVPLLAIINEVWFR.....NTSML-NLDVGRARLDAKV 23 N----DE.....LCIRLHGPWLHVILFEVPLLAIVSEVRNR.....HRYPDTLLSQARDRLYDKF 24 A-AHPGE.....IELTIRGPWLHTILFEVPLLAIINEVWFR.....NTS-EPDFEEGRSRLREKV 25 G----EQ.....LAIRIKGPMVQAMFFEIFVLAIVNELYFR.....PLDSKAVREEGRRRLEAKL 26 N----GK.....LNIRLTGPWREVIMWEVPLLAVISELVHH.....YRSPNAGVDQALDALESKL 27 N----GK.....LNIRLTGSWREVIMWEVPLLAVISELVHH.....YRSPNAGVDQALDALESKL 28 N----DE.....LCIRLHGPWLHVILFEVPLLAIVSEVRNR.....HRYPDTLLSQARDRLYDKF 29 N---GGQ.....LAIHISGLWYEVIMWEVPLLALISELIHR.....HHSPDNTVENAVNQLRKLI 30 N----GE.....LFIRLRGPWLHVILFEVPLLAIVSEVRNR.....YRYRETVLEQAREQLYRKF 31 SVVFPKV.....PLLRIEGPVAVVQLLETPFLNLIN-----.....-------YASLVATNAARH 32 D---KGR.....LNIRIEGPMIQAMFFEIFILAIVNELYFR.....RLETPAVIEEGERRLQAKA 33 D---KGR.....LNIRIEGPMIQAMFFEIFILAIVNELYFR.....RLETPAVIEEGERRLQAKA 34 D---KGR.....LFIDIEGPMIQAMFFEVFVLAIVNELYFK.....ALTDASVLEEGQRRLDEKV 35 D---KDR.....LNIRIEGPMIQAMFFEIFILAIVNELYFR.....RLETPAVIEEGERRLQAKA 36 N----DE.....FFLRLKGPWLHVILFEVPLLAMISEVRNR.....ARYPAATVEQARERLQEKF 37 SVAFPRV.....PLIKVAGPLIIVQLLETTLLTLVN-----.....-------YASLMATNAARY 38 TVAFPRV.....PIIKIEGPLIIVQLLETTLLTLVN-----.....-------YASLMATNAARY 39 SVVFPKV.....PLMRVEGPVGVVQLLETPFLNLVN-----.....-------FASLVATNAARH 40 D----GK.....LDIRIAGLWCEVIMWEVPLLAVISEIVHR.....RRSTQVTTDQAVQQLRTKL 41 D----GK.....LDIRIAGLWCEVIMWEVPLLAVISEIVHR.....RRSTQVTTDQAVQQLRTKL 42 SVVFPKV.....PLMIIEGPVAVIQLLETPFLSLVN-----.....-------YASLVTTNAARH 43 G-EERYD.....LNITVTGLWKDTILYEIHMLALISEAYFK.....FVDTDWVLDGQVEQAYRKT 44 DDSIEGD.....VDIQIKGTWVDTILYEIPMLALTSEAYFK.....FMDTDWNYEGQEKQAFEKG 45 SVVFPKV.....PLMRVEGPVGVVQLLETPFLNLVN-----.....-------FASLVATNAARH 46 SVVFPKV.....PLLTIYGPLAMCQLLETSILNLVN-----.....-------YASLVATNAARF 47 DDSIVGD.....VDIQIKGTWVDTILYEIPMLALTSEAYFK.....FMDTDWNYEGQEKQAFDKG 48 D---LGD.....IHYDIKGNWAETILYEIPLLALTSEAYFK.....FMDTDWDYDGQEEKAYEKG 49 TVVFPKI.....PLLRVEGPVAAVQLLETPFVNLIN-----.....-------FASLVSTNAARH 50 N----DQ.....LFLRLKGPWLHVILFEVPLLAIISEVRNR.....NLHPHMRLAEARDQLYRKF 51 SVVFPKV.....PLLTINGPLAMCQLIETSILNLVN-----.....-------YASLVATNAARF 52 SVVFPKV.....PLLTINGPLAMCQLIETSILNLVN-----.....-------YASLVATNAARF 53 SVVFPKV.....PLLTINGPLAMCQLIETSILNLVN-----.....-------YASLVATNAARF 54 SVVFPKV.....PLLTINGPLAMCQLIETSILNLVN-----.....-------YASLVATNAARF 55 Q----GR.....LHIRISGLWKEVILWEVPILALISEVFHG.....NFSPEITSQSALQYLDIKL 56 -----GD.....FELEIVGKWNDTILYEIPLLALVSEAYFK.....FVDTDWNYEGQYALAQKKA 57 DLVFNNE.....PILQVEGPLADCQLIETALLNIVN-----.....-------YQTLIATKAARI 58 ELCFGNE.....PLLRVEAPLIQAQLIETILLNIVN-----.....-------FHTLITTKASRI 59 ELCFGNE.....PLLRVEAPLIQAQLIETILLNIVN-----.....-------FHTLITTKASRI 60 SVVFPKV.....PLMRVEGPVAVVQLLETPFVNLIN-----.....-------YASLVTTNAARH 61 DLVFNNE.....PLLQVEGPLATCQLIETALLNIIN-----.....-------YQTLIATKAARI 62 ELCFGNE.....PLLRVEAPLIQAQLIETILLNIVN-----.....-------FHTLITTKASRI 63 EVMFNNE.....PLLQVEGPLVDAQLLETLLLNIIN-----.....-------FQTLIATKAARI 64 DLVFNNE.....PLIQIEGPLAQCQLVETALLNMVN-----.....-------FQTLIATKAARI 65 SVVFPRV.....PLLRVEGPMILCQLFETTLLCLVN-----.....-------FASLVATNAARH 66 SVAFPRV.....PLIKVAGPLIIVQLLETTLLTLVN-----.....-------YASLMATNAARY 67 SVAFPRV.....PLIKVAGPLIIVQLLETTLLTLVN-----.....-------YASLMATNAARY 68 ELCFGNE.....PLLRVEAPLIQAQLIETILLNIVN-----.....-------FHTLITTKASRI 69 SVVFPKV.....PLMRVEGPVAVVQLLETPFVNLIN-----.....-------YASLVTTNAARH 70 SDSDFGD.....IDYIVKGAWVDTILYEIPLLALTSQAYFM.....FSDKDWNYECQEGKAYRKG 71 ELVFANE.....PLIQVEGPLAHCQLVETALLNMVN-----.....-------FQTLIATKAARI 72 H----GQ.....LHIRISGLWKEVILWEVPILSLISEIFHR.....HCYPEITSNIAVQHLNKKL 73 S----SQ.....LRITINGLWKETILYETIIMSIVSEVRSR.....QRWSDIPFEQFQTVLEDKV 74 ELVFANE.....PIMQIEGPLAQAQLVETAILNIIN-----.....-------FQTLIATKAARI 75 TVVFPYE.....PLVRVKGRILEAQLIETALLNIIN-----.....-------FETLIATKASRV 76 DLVFANE.....PIVQVEGPLAQCQLVETALLNIVN-----.....-------YQTLVATKAARI 77 ELVFANE.....PIMQVEGPLAQAQLVETAILNIIN-----.....-------FQTLIATKAARI 78 -----GQ.....YELHFHGPWTHTTMWEIPALAIINELRSRaa7lgPFSLDVLYARAKAKMWSKV 79 G----DQ.....LSIKIKGKWIDIILWEVPLLAIICEIRSS.....ICYPHSTADDAIAQLKTKI 80 TVAFPRV.....PIIKIEGPLIIVQLLETTLLTLVN-----.....-------YASLMATNAARY 81 DLVFANE.....PLVQIEGPLAQCQLVETAILNIIN-----.....-------YQTLVATKAARI 82 QLAFANE.....PLVQVEGSLAECQLVETAILNIIN-----.....-------FQTLIATKAARI 83 SLAFPGV.....PLLQVSGPLLVVQLLETPLLCLVS-----.....-------YASLVATNAARV 84 SLAFPGV.....PLLQVSGPLLVVQLLETPLLCLVS-----.....-------YASLVATNAARV 85 EICFGNE.....PLLRVEAPLIQAQLIETILLNIIN-----.....-------FQTLIATKASRI 86 SLAFPGV.....PLLQVSGPLLVVQLLETPLLCLVS-----.....-------YASLVATNAARV 87 -----GQ.....YELHFHGPWTHTTMWEIPALAIINELRSRaa7lgPFSLDVLYARAKAKMWSKV 88 DLVFANE.....PIVQVEGPLGQCQLVETALLNIVN-----.....-------FQTLIATKAARI 89 DLVFANE.....PIVQVEGPLGQCQLVETALLNIVN-----.....-------FQTLIATKAARI 90 DLVFANE.....PIVQVEGPLGQCQLVETALLNIVN-----.....-------FQTLIATKAARI 91 ADSDVGD.....IDIQISGKWVDTILYEIPILALTSEAYFR.....FMDTDWDYQGQEELAYEKG 92 -----GQ.....YELNFHGRWMDTTLWEIPALSIINELRSRsa7lgYFTLDVLYARAKAKMWEKV 93 -----GQ.....YELNFHGRWMDTTLWEIPALSIINELRSRsa7lgYFTLDVLYARAKAKMWEKV 94 -----GQ.....YILHFHGPWTHSSMWEIPALSIISELRSRaa7ldRFTLDVLYARAKAKMWSKV 95 EVVFNNE.....PLLRVDAPLGEAQIIETALLNIVN-----.....-------YQTLIATKAARM 96 -----GQ.....YELSFSGPWMYTTLWEIPALAIINELRSRaa7fgPFALDVLYARAKAKMWAKT 97 EVVFNNE.....PLLRVDAPLGEAQIIETALLNIVN-----.....-------YQTLIATKAARM 98 EVVFNNE.....PLLRVDAPLGEAQIIETALLNIVN-----.....-------YQTLIATKAARM 99 -----GQ.....FELTFRGRWAETTMWEIPALAIINELRSRaa7lgPFTLDVLYARAKAKMWSKV 100 EVVFNNE.....PLLRVDAPLGEAQIIETALLNIVN-----.....-------YQTLIATKAARM 101 -----GQ.....YILHFHGPWSHSSMWEIPALAIISELRSRaa7ldRFALDVLYARAKAKMWSKV 102 DLVFANE.....PIVQIEGPLAQCQLVETAILNIVN-----.....-------FQTLIATKAARI 103 SVVFPKV.....PLMIIEGPVAVIQLLETPFLSLVN-----.....-------YASLVTTNAARH 104 EVVFNNE.....PLLRVDAPLGEAQIIETALLNIVN-----.....-------YQTLIATKAARM 105 SLAFPGV.....PLLQVSGPLLLVQLLETPLLCLVS-----.....-------YASLVATNAARL 106 GKPTHYK.....LKILVSGSWKDTILMRSLT-VLISEAYLI.....VTSTGLRN---HRQAEKKA 107 -----GQ.....FELHFYGRWMETTMWEIPALAIINELRSRaa7lgRFALDVLYARAKAKVWEKV 108 TPIFPNE.....PIITVRGPVIQAQFIETMILLTIN-----.....-------HQSLIATKANRI 109 D----CQ.....LRVTINGIWHETILYETLVMSIISELRNR.....RYWAQIPQSQLHKVLEDKL 110 D----CQ.....LRVTINGIWHETILYETLVMSIISELRNR.....RYWAQIPQSQLHKVLEDKL 111 ----TKD.....LSIFIHGLWKNTIFYEIPLLALVSESYFK.....FVDKDWSPEGQFEKAYEKG 112 SVVFPKV.....PLLRIEGPVAVVQLLETPFLNLIN-----.....-------YASLVATNAARH 113 SLAFPGV.....PLLQVSGPLLLVQLLETPLLCLVS-----.....-------YASLVATNAARL 114 SLAFPGV.....PLLQVSGPLLVVQLLETPLLCLVS-----.....-------YASLIATNAARL 115 ----EKE.....LDIRIKGPWHSTILWEIVLMAAVSELYFT.....TIEKEWNGKEWDGNISATS 116 ----EKD.....LDIRIKGPWHSTILWEIVLMATVSELYFT.....TIEKEWNGDSQGGCTSESV 117 TPVFPNE.....PLVTVKGPIIQAQFVETMILLSIN-----.....-------HQTLIATKANRI 118 -----GQ.....YELHFHGPWTHTTMWEIPALAILNELRSRaa7rgRFELDVLYARAKAKLWTKV 119 EIVFANE.....PILRVEASLAEAQLLETALLNIVN-----.....-------YQTLIATKASRI 120 SLAFPGV.....PLLQVSGPLLLVQLLETPLLCLVS-----.....-------YASLVATNAARL 121 -----ND.....LDMRIKGPWHSTILWEIVLMAAVSELYFT.....TIEKEWNGSTKNPGTPESA 122 SVVFARV.....PLLEVSGPLAVVQLLETSLLCLVN-----.....-------YASLVCSNAARF 123 NPVFPNE.....PLVIVKGPVIQAQFVETMILLTIN-----.....-------HQTLIATKANRI 124 ELVFNNE.....PIMRVEAPLVEAQLIETALLNIVN-----.....-------YQTLIATKAARI 125 SVVFPHE.....PLLTVRGPLWEAQLVETALLNTLN-----.....-------FQTLVATKAARC 126 TVVFANE.....PLVTVDAPLAQAQLVETALLNIIN-----.....-------FQTLVATKAARI 127 EFVFKTE.....PILQVEASLAEAQLIETALLNIVN-----.....-------FQTLIATKAARI 128 EFVFKTE.....PILQVEASLAEAQLIETALLNIVN-----.....-------FQTLIATKAARI 129 EFVFKTE.....PILQVEASLAEAQLIETALLNIVN-----.....-------FQTLIATKAARI 130 EFVFKTE.....PILQVEASLAEAQLIETALLNIVN-----.....-------FQTLIATKAARI 131 SLAFPGV.....PLLQVSGPLLVVQLLETPLLCLVS-----.....-------YASLVATNAARL 132 SLAFPGV.....PLLQVSGPLLVVQLLETPLLCLVS-----.....-------YASLVATNAARL 133 NPVFPNE.....PLVTVKGPAIQAQFVETMILLTIN-----.....-------HQTLIATKANRI 134 TPVFPNE.....ALITVKAKAIEAQLIETMLLITIN-----.....-------HECLIATKTNRI 135 TVVFANE.....PLVTIEAPLAQAQLVETALLNIIN-----.....-------FQTLVATKGARI 136 SLAFPGV.....PLLQVSGPLLLVQLLETPLLCLVS-----.....-------YASLVATNAARL 137 RIVFQNE.....PLVQVEAPIPEAQLLETLVINTIQ-----.....-------FETMIASKAVRS 138 G---WGH.....LDLNVSGVWSDVIFYEVPLMAIVSEVYFS.....TIDTDWSLQDQYQQAFDKA 139 -----GQ.....YELTFEGKWPEVMLWEIPALAVLMELRSRav7mgRFELQVLYARAMTKLWEKI 140 EVIFPNE.....PLLCIKATTIEAQLLETFLLLSLN-----.....-------HQSLIATKTNRI 141 TIVFAGE.....PVIIVRGPLLLCQLLESTLLVLIN-----.....-------YPTLVCTKACRL 142 SVIFPHE.....PIIRVHARLVEALLLEGLILNTIN-----.....-------FQSLIATKTARM 143 TPVFPRE.....PLLTISGPLIETQLFETILLNIVN-----.....-------HQSLIATKARRI 144 G---KQQ.....LRISIRGSWRDTILYETLVMAIVSEVRSR.....QRWAEVPADLPLKVLKTKL 145 RIVFPQA.....PVVVIEGHLIELLLIEGLVLNIIN-----.....-------FESLIATKTARI 146 SLVFPNE.....PLIRIEADTVEALLLEGLILNMIN-----.....-------FQTLIATKTARI 147 RIVFPHE.....PILIIEGNLIELLLIEGLVLNITI-----.....------NFESLIATKTARI 148 YVVFPKV.....PLIRLEGPLPVIQLLETTLLNLVN-----.....-------YASLVATNAARF 149 TPVFPRE.....PLLTITGPLEQAQLLETLALNIVN-----.....-------HQSLIATKARRL 150 TAIFPNQ.....PLLRIEAPLWQGQLVETYLLNTMN-----.....-------YQTLIATKAARM 151 A---QGH.....LDIRAQGLLYRVTLWETPILAVISELYYR.....FIGAEPDWKQVEEVTRSKG 152 T---TGR.....LHIEVSDFLYKVTLYEVPLLAIVSEIKNK.....FFGNVPDMSEILCKLSEKV 153 SIVFANE.....PLITLEGPLLICQILESAILNLIN-----.....-------YPTLIATNSMMH 154 TAVFANE.....PLLRVEAPLWQAQLVETYLLNTLN-----.....-------YQTLVATRAARL 155 SVVFPNE.....PLMVIEGPLLICQILESVILNLMN-----.....-------YPTLISTNSIMY 156 TAVFANQ.....PLLRVEAPLWQAQLVETYLLNTIN-----.....-------YQTLIATKAARL 157 DVVFPTR.....PILSVEAPLIEAQIVETLLLNILN-----.....-------FQTLIATKASRM 158 TPFFADE.....PILRVVAPLPEAQLVESRLINLLH-----.....-------FQTLIASKAARL 159 ----DNE.....LELCIEGPWHSSILWEIVLMSTISELYFT.....VTDNKGEEISASNANDPEN 160 IPIFANE.....PLLRVEAPLWQAQIVETYLLNTIN-----.....-------YQTLIATRAARM 161 TVIFPNE.....PAVQLIAPIIEAQLVETFVLNQIH-----.....-------LQSVLASKAARV 162 EMFFPNS.....PILQVEGTFGECTLLETLILSVLN-----.....-------YDSAVASAASRM 163 EIVYPNE.....PIITIKAPLIEAKILETPILNIMN-----.....-------MNMAIATKASMV 164 EMFFPNS.....PILQVEGTFGECTLLETLILSVLN-----.....-------YDSAVASAASRM 165 TVVFAQE.....PLLRIDAPLWQGQWIETCLLNIVN-----.....-------YQTLVATRASRL 166 SVVFARV.....PLMEVEGPLAVVQLVETSLLCLVN--YAR.....GVPELLRMWEPGLQQRRSL 167 EIYFPQS.....PLLTVRGTFAECVILETVILSIMN-----.....-------ADSAVASAAARM 168 ELYFPHS.....PLLTVRGTFAECVVLETVILSIMN-----.....-------ADSAVASAAARM 169 D----GR.....INVRVEGPWQDVILWEIPVLAIISEMRNR.....FRYPQFGVTQALERLDQKI 170 EIVYPNE.....PVITIKAPLIQAKILETPILNIMN-----.....-------MNMAISTKASMV 171 ELYFPHS.....PILTVRGTFAECVILETVILSIMN-----.....-------ADSAVATAAARM 172 -------.....-----------------------------.....------------------- 173 SVVFPKV.....PLLTINGPLAMCQLIETSILNLVN-----.....-------YASLVATNAARF 174 -------.....-----------------------------.....------------------- 175 -------.....-----------------------------.....------------------- 176 -------.....-----------------------------.....------------------- 177 DINGIPV.....PFLRISGKYLDFAELETPLLGFLC-----.....-------QASGISSYSSLL 178 -------.....-----------------------------.....------------------- 179 TLIKNRDek6pvPFLIIHGRYLDFAIYETALLGFLC-----.....-------QASGISSYSSMI 180 -------.....-----------------------------.....------------------- 181 -------.....-----------------------------.....------------------- 182 -----GQ.....FELTFRGRWAETTXWEIPALAIINELRSRaa7lgPFTLDVLYARAKAKMWSKV 170 180 190 200 210 | | | | | 1 ETLF.....DNGIRFSEFGTRRRRSLKAQDLIMQGIM.....KA.VNGNPD.RNKSLLLGTSNIL 2 KLLGarpe.FADCKIADYGTRRRFSKQWHEEVILKLK.....EG.L-----.--GEQFAGTSNVF 3 ELLAapp..YVDCVIADYGTRRRFSCDWQEEVLLSMR.....DA.I-----.--GPQLAGTSNVH 4 KLLGakpe.FADCKIADYGTRRRFSKVWHEEVALTLR.....DG.L-----.--GPQFAGTSNVF 5 KLLGakpe.FADCKIADYGTRRRFSKVWHEEVALTLR.....DG.L-----.--GPQFAGTSNVL 6 ASLTrpg..LEDCRIADYGTRRRFSHTWHEHVLMEAR.....SQ.L-----.--GSQYAGTSNVY 7 ETLF.....DNGIRFSEFGTRRRRSLKAQDLIMQGIM.....KA.VNGNPD.RNKSLLLGTSNIL 8 ASLTrpg..LEDCRIADYGTRRRFSHTWHEHVLMEAR.....SQ.L-----.--GSQYAGTSNVY 9 VDFSal7ldMSRFHLMDFGTRRRFSREVQETIVKRLQ.....Q-.------.--ESWFVGTSNYD 10 VDFSal7ldMSRFHLMDFGTRRRFSREVQETIVKRLQ.....Q-.------.--ESWFVGTSNYD 11 VDFSal7ldMSRFHLMDFGTRRRFSREVQETIVKRLQ.....Q-.------.--ESWFVGTSNYD 12 VDFSal7ldMSRFHLMDFGTRRRFSREVQETIVKRLH.....Q-.------.--ESWFVGTSNYD 13 VDFSal7ldMSRFHLMDFGTRRRFSREVQETIVKRLQ.....Q-.------.--ESWFVGTSNYD 14 NLVLddpa.LADFRVAEYGTRRRFSKVWHEEIVSTMK.....AR.M-----.--GVHFAGTSNVL 15 DWLSaq7eeLAEFQVADFGTRRRFSYRTQEEVVHILK.....RD.F-----.--PGRFVGTSNVH 16 NLVLddpa.LADFRVAEYGTRRRFSKVWHEEIVSTMK.....AR.M-----.--GVHFAGTSNVL 17 DWLSaq7eeLAEFQVADFGTRRRFSYRTQEEVVHILK.....RD.F-----.--PGRFVGTSNVH 18 NLVLddpa.LADFRVAEYGTRRRFSKVWHEEIVSTMK.....AR.M-----.--GVHFAGTSNVL 19 ASLRsm...PAGCKIADYGTRRRYSRQWHGELLPLLR.....DG.L-----.--GEQFVGTSNVY 20 RLLKdesg.YEECSIADYGTRRRYSRQWHAELLPLLA.....QG.L-----.--GSNFVGTSNVY 21 RLLKdesg.YEECSIADYGTRRRYSRQWHAQLLPLLA.....QG.L-----.--GSNFVGTSNVY 22 RLLKgesg.YEECSIADYGTRRRYSRQWHAELLPLLA.....QG.L-----.--GSNFVGTSNVY 23 EWLTvn7deLAELKVADFGTRRRFSYRVQEEVLNVLK.....LD.F-----.--PGQLVGTSNVH 24 RSLRsm...PAGCKIADYGTRRRYSRQWHGELLPLLR.....DG.L-----.--GEQFVGTSNVF 25 AELEr10gqRFPLLIADFGTRRRFSRDWQAHVVERLN.....HA.L-----.--PQVFRGTSNVY 26 VDFTal7ldMSRFHLMDFGTRRRFSREVQQAIVKRLQ.....Q-.------.--ESWFVGTSNYD 27 VDFTal7ldMSRFHLMDFGTRRRFSREVQQAIVKRLQ.....Q-.------.--ESWFVGTSNYD 28 EWLTth7deLAELKVADFGTRRRFSYRVQEEMLGVLK.....ND.F-----.--PGQFVGTSNVH 29 KLFYqh9idLSSFKLMDFGTRRRFSHRVQHAVVSELQ.....QH.F-----.---PYLIGTSNYQ 30 DWLTan7eeLSQLQVADFGTRRRFSYRVQEEVVNVLK.....HD.F-----.--PGRFVGTSNVH 31 RFVA.....GKSKLLLEFGARRAQGPDG---------.....-A.ISASKY.CYLGGFDATSNVA 32 ARLKei9pdEPPFLISDFGTRRRYKLAWQEHVIRTLL.....EA.A-----.--PSIVRGTSNVF 33 ARLKei9pdEPPFLISDFGTRRRYKLAWQEHVIRTLL.....EA.A-----.--PSIVRGTSNVF 34 ELLHr12rdIPPFIVADFGTRRRFNKDWQAHVVETLH.....KA.E-----.--PKIVGGTSNVY 35 ARLKei9pdEPPFLISDFGTRRRYKLAWQEHVIRTLL.....EA.A-----.--PGIVRGTSNVF 36 DWLRre7eeLAGFKMADFGTRRRFSYRVHEAVVSGLK.....ED.F-----.--PGCFVGTSNVH 37 RMVA.....GKHIHLLEFGLRRAQGPDG---------.....-G.LSASKY.SYIGGFDGTSNVL 38 RMVA.....GKHVKLLEFGLRRAQGPDG---------.....-G.LSASKY.SYTGGFDGTSNVL 39 RFVA.....GKSKSLLEFGARRAQGPDG---------.....-A.ISASKY.CYLGGFDATSNVA 40 EQFNal7idITHFKLMDFGTRRRFSREIQHTVVSTLK.....DE.F-----.---PYLVGTSNYD 41 EQFNal7idITHFKLMDFGTRRRFSREIQHTVVSTLK.....DE.F-----.---PYLVGTSNYD 42 RLVA.....GKSKNLLEFGLRRAQGPDG---------.....-G.ISASRY.CYMGGFDATSNVA 43 RLLL.....DNGLVFSEFGTRRRRSLLVQDLVLQGIA.....EA.V-ADSG.TGDTQFIGTSNVY 44 LKLL.....EAGCITSEFGTRRRRDYHTQALVFRGLV.....QAsKEAEKK.GFPGKLSGTSNVH 45 RFVA.....GKSKSLLEFGARRAQGPDG---------.....-A.ISASKY.CYLGGFDATSNVA 46 RQAA.....GNKINLLEFGLRRAQGPNG---------.....-G.LTASKY.CYIGGFDGTSNVL 47 LQLL.....EAGCVTSEFGTRRRRDYHTQALVFRGLV.....QAsKEAEKK.GFPGKLSGTSNVH 48 MRLL.....EAGCVFSEFGTRRRRDYHTQALVFRGLT.....KAaKEAEKR.GLTGKLSGTSNVH 49 RKVA.....GKSKTLLEFGLRRAQGPDG---------.....-G.ISASKY.CYIGGFDATSNVA 50 DWLRah7deLAELQVADFGTRRRFSSRVQEEVARVLR.....DD.F-----.--PGRFVGTSNVD 51 RQAS.....GWKIQLLEFGLRRAQGPNG---------.....-G.LTASKY.CYIGGFDATSNVL 52 RQAS.....GWKIQLLEFGLRRAQGPNG---------.....-G.LTASKY.CYIGGFDATSNVL 53 RQAS.....GWKIQLLEFGLRRAQGPNG---------.....-G.LTASKY.CYIGGFDATSNVL 54 RQAS.....GWKIQLLEFGLRRAQGPNG---------.....-G.LTASKY.CYIGGFDATSNVL 55 KKFFnr7idLSHLKIVDFGTRRRFSYDVQYSIVKRLK.....ES.F-----.---PFLIGSSNYH 56 KQLI.....SNECNFSEFGTRRRRSYESQEIVIKAIK.....DV.QIDTQS.KY---IAGTSNVY 57 KSVV.....-GSDKLLEFGTRRAQEMDA---------.....-A.LWGTRA.AYIGGFDATSNVR 58 RQIA.....-SNDKLMEFGTRRAQEIDA---------.....-A.LWGARA.AYIGGFDSTSNVR 59 RQIA.....-SNDKLMEFGTRRAQEIDA---------.....-A.LWGARA.AYIGGFDSTSNVR 60 RHVA.....GKSKVLLEFGLRRAQGPDG---------.....-A.ISASKY.CFMGGFDATSNVL 61 KSVV.....-GEDGLLEFGTRRAQEFDA---------.....-A.IWGTRA.AYIGGFDATSNVR 62 RQIA.....-SNDKLMEFGTRRAQEIDA---------.....-A.LWGARA.AYIGGFDSTSNVR 63 ASVT.....-NGDPLLEFGTRRAQELDA---------.....-A.LWGTRA.AFIGGFDATSNVR 64 KSVI.....-GDDPLLEFGTRRAQELDA---------.....-A.IWGTRA.AYIGGADATSNVR 65 RLAV.....GKEKVMLEFGLRRAQGPDG---------.....-A.MSASRY.SYLGGADGTSNVL 66 RMVA.....GKHIHLLEFGLRRAQGPDG---------.....-G.LSASKY.SYIGGFDGTSNVL 67 RMVA.....GKHIHLLEFGLRRAQGPDG---------.....-G.LSASKY.SYIGGFDGTSNVL 68 RQIA.....-SIDKLMEFGTRRAQEIDA---------.....-A.LWGARA.AYIGGFDSTSNVR 69 RHVA.....GKSKVLLEFGLRRAQGPDG---------.....-A.ISASKY.CFMGGFDATSNVL 70 YVLL.....ENGCTFSEFGTRRRRSYHTQDLVMQGLC.....RA.AREGKAkGLPGVFTGSSNVH 71 KSVI.....-GEDPLLEFGTRRAQELDA---------.....-A.VWGTRA.AYIGGADATSNVR 72 KEFFkk7vdLSRLKIVDFGTRRRFSYDVQYSIIKRLK.....DT.F-----.---PFLIGSSNYH 73 RYLKae7rnITNFKFADMSTRRRFSFQAQRTMLEYLS.....KE.L-----.--PQCLTGTSNYH 74 KVAV.....-GNDGLMEFGSRRAQETDA---------.....-A.IWGTRA.AYIGGFDATSNVR 75 VAAA.....-GGGSVMEFGLRRAQGPDA---------.....-G.ILGSRA.AFIGGCQFTSNVL 76 RSVI.....-EDEPLMEFGTRRAQEMDA---------.....-A.IWGTRA.AVIGGANGTSNVR 77 KVAV.....-GNDGLMEFGSRRAQETDA---------.....-A.IWGTRA.AYIGGFDATSNVR 78 ERLRq....LPDLKISDFGTRRRHSFLWQRWCVEALK.....EG.I-----.--GSAFTGTSNVL 79 ERFYl15tdLSQFDLIDFGSRRRFSKDVHHKVVDYLA.....AN.V-----.---PEFKGTSNYH 80 RMVA.....GKHVKLLEFGLRRAQGPDG---------.....-G.LSASKY.SYTGGFDGTSNVL 81 RSVI.....-EDEPLLEFGTRRAQEMDA---------.....-A.IWGTRA.AIIGGANATSNVR 82 KSVI.....-GDDPLLEFGTRRAQEMDA---------.....-A.IWGTRA.AIIGGADATSNVR 83 RLIA.....GPEKRLLEMGLRRAQGPDG---------.....-G.LTASTY.SYLGGFDSSSNVL 84 RLIA.....GPEKRLLEMGLRRAQGPDG---------.....-G.LTASTY.SYLGGFDSSSNVL 85 RQIA.....-THDTLMEFGTRRAQEIDA---------.....-A.LWGARA.AFIGGFDSTSNVR 86 RLIA.....GPEKRLLEMGLRRAQGPDG---------.....-G.LTASTY.SYLGGFDSSSNVL 87 ERLRq....LPDLKISDFGTRRRHSFLWQRWCVEALK.....EG.I-----.--GSAFTGTSNVL 88 RSVI.....-EDEPLLEFGTRRAQELDA---------.....-A.IWGTRA.AIIGGADATSNVR 89 RSVI.....-EDEPLLEFGTRRAQELDA---------.....-A.IWGTRA.AMIGGADATSNVR 90 RSVI.....-EDEPLLEFGTRRAQELDA---------.....-A.IWGTRA.AMIGGADATSNVR 91 KRIL.....EAGCILSEFGTRRRRDYHTQALVFRGLV.....KAsKEAQKR.GLSGKLSGTSNVH 92 ERLRe....LPGLRISDFGTRRRHSFLWQRWCVEALK.....EG.I-----.--GPAFTGTSNVL 93 ERLRe....LPGLRISDFGTRRRHSFLWQRWCVEALK.....EG.I-----.--GPAFTGTSNVL 94 ERLKk....LPNIKISDFGTRRRHSFLWQRWCVEALK.....EG.I-----.--GNSFTGTSNVL 95 KHAA.....-NNDELLEFGTRRAHEFDA---------.....-A.LWGTRA.AFIGGFSSTSNVR 96 ERLKa....LPGIRISDFGTRRRHSFLWQRWCVEALK.....EG.I-----.--GEAFTGTSNVL 97 KHAA.....-NNDELLEFGTRRAHEFDA---------.....-A.LWGTRA.AFIGGFSSTSNVR 98 KHAA.....-SNDELLEFGTRRAHEFDA---------.....-A.LWGTRA.AFIGGFSSTSNVR 99 EQLRe....HPNLRISDFGTRRRHSFLWQRWCVEALK.....EG.I-----.--GSSFTGSSNVL 100 KHAA.....-NNDELLEFGTRRAHEFDA---------.....-A.LWGTRA.AFIGGFSSTSNVR 101 EQLKk....LPDIKISDFGTRRRHSFLWQRWCVEALK.....EG.I-----.--GDSFTGTSNVL 102 RSVI.....-EDEPLLEFGTRRAQEMDA---------.....-A.IWGTRA.AVIGGANATSNVR 103 RLVA.....GKSKNLLEFGLRRAQGPDG---------.....-G.ISASRY.CYMGGFDATSNVA 104 KHAA.....-NNDELLEFGTRRAHEFDA---------.....-A.LWGTRA.AFIGGFSSTSNVR 105 RLIA.....GPDKKLLEMGLRRAQGPDG---------.....-G.FTASIY.SYLGGFDSSSNTL 106 ETLF.....DNGIRFRIHGTRRRRSLKAQDLIMQGIM.....KA.VNGNPD.RNKSLLLGTSNIL 107 ERLKk....YPDIRISDFGTRRRHSFLWQRWCVEALK.....EG.I-----.--GESFTGTSNVL 108 VRAA.....-QGRPVLEFGTRRAQGYDG---------.....-A.VLGARA.AYIGGCAGTACAI 109 DFLDse7rnITNFRFSEMGTRRRFSFAAQKTMLDVLR.....AR.V-----.--PELLLGTSNYH 110 DFLDse7rnITNFRFSEMGTRRRFSFAAQKTMLDVLR.....AR.V-----.--PELLLGTSNYH 111 KRLI.....RAGCAFTDFGTRRRRDPHTQEIVLQGLM.....KA.QEDFKG.--PGSFLGTSNVY 112 RFVA.....GKSKLLLEFGARRAQGPDG---------.....-A.ISASKY.CYLGGFDATSNVA 113 RLIA.....GPDKKLLEMGLRRAQGPDG---------.....-G.FTASIY.SYLGGFDSSSNTL 114 RLIA.....GPDKRLLEMGLRRAQGPDG---------.....-G.LTASTY.SYLGGFDASSNVL 115 ESILt15leENGCLFAEFGTRRRRSFELHDQVMKTLL.....Q-.------.--IETLTGTSNVF 116 LTAYe12leKNNCLFSEFGTRRRRSSELHDHVMKTLT.....G-.------.--IKTLTGTSNVY 117 CRAA.....-EGRSVMEFGSRRAQGYDG---------.....-A.IYGARA.AIIGGCNSTACTI 118 ERLRk....LENLRLSDFGTRRRHGFLWQRWCVEAVK.....EG.L-----.--GPSFIGTSNVL 119 RQLV.....-GDQLVMEFGTRRAQEMDA---------.....-A.VWGTRA.AFIGGFSATSNVR 120 RLIA.....GPDKRLLEMGLRRAQGPDG---------.....-G.FTASIY.SYLGGFDSSSNTL 121 TLESv17leENGCLFSEFGTRRRRSFELHDQVMRSLV.....R-.------.--IKTLTGTSNVY 122 RLAA.....GPRRRLMEMGLRRAQGPDG---------.....-G.LTASRY.TYIGGFDLTSNAL 123 CRAA.....-KDKTVMEFGSRRAQGYDG---------.....-A.IYGARA.AAIGGCDSTACTI 124 KGVI.....-GDEVALEFGTRRAHEMDA---------.....-A.MWGARA.ALIGGFSATSNVR 125 VLAAq....AGGGTVLEFGARRAQGPNG---------.....-A.VSAARA.AFVGGAVGTSNLE 126 VHAA.....-ADGTVLEFGLRRAQGPDG---------.....-G.LSEARA.AYVGGVRSTSNVL 127 RSVI.....-DDETFAEFGTRRAQEMDA---------.....-A.IWGTRA.AYIGGCDSTSNVR 128 RSVI.....-DDETFAEFGTRRAQEMDA---------.....-A.IWGTRA.AYIGGCDSTSNVR 129 RSVI.....-DDETFAEFGTRRAQEMDA---------.....-A.IWGTRA.AYIGGCDSTSNVR 130 RSVI.....-DDETFAEFGTRRAQEMDA---------.....-A.IWGTRA.AYIGGCDSTSNVR 131 RLIA.....GPEKRLLEMGLRRAQGPDG---------.....-G.LTASTY.SYLGGFDSSSNVL 132 RLIA.....GPEKRLLEMGLRRAQGPDG---------.....-G.LTASTY.SYLGGFDSSSNVL 133 CRAA.....-GNRPVMEFGSRRAQGYDG---------.....-A.IYGARA.AVIGGCSSTACTI 134 VRAA.....-KGRPVLEFGARRAQGYDG---------.....-A.VYGARA.SYIGGAAGTATTL 135 VHAA.....-VDGTVLEFGLRRAQGPDG---------.....-G.VSEARA.AYIGGVRSTSNVL 136 RLIA.....GPDKRLLEMGLRRAQGPDG---------.....-G.FTASIY.SYLGGFDSSSNTL 137 YLVA.....-KGKKLVDFGFRRAHGLEA---------.....-G.ILAARA.SYIAGFDGTSNVE 138 CRLT.....SNGIRYSEFGTRRRRSYQTHRIVLQGLM.....AGdLSASSG.CSSGKLLGTSNVH 139 ERLKr....IERLKIADFGTRRRHSFLWQDWCVQAMI.....EG.L-----.--GDAFTGTSNCL 140 VRAA.....-KDSKILEFGSRRAQGSEA---------.....-A.LKGARA.AFIGGCIGSACTL 141 RVACn24siCSNPVLSEFGLRRAQGVNG---------.....-G.ICASEY.AIMGGCNGTSNMY 142 WRAS.....-GEGVLMEFGLRRAQGYDG---------.....-A.LSATRA.AAIGGATGTSNTL 143 CYAA.....-QGMPIMEFGARRAQGPSA---------.....-A.TLGARA.AIIGGCASTSNLL 144 DQLKae7rgINNFSLTEMGTRRRFSSQVQRDVLACLK.....QE.I-----.--PQWVLGTSNYH 145 KES-.....-GAKILAELGLRRAQGING---------.....-A.LSASKA.AYIGGADFTSNML 146 WLAS.....-KKGSIMEFGLRRAQGNDG---------.....-A.MSATRA.AYIGGAFGTSNSL 147 KEA-.....-GATNLAEFGLRRAQGING---------.....-A.LSASKA.AYIGGADFTSNVL 148 RITA.....GESVQLLEFGLRRAQGPDG---------.....-G.LSASKY.CYIGGFDGTSNVL 149 SYAA.....-AGRPIMEFGARRAQGPDS---------.....-A.LYGTRA.AIIGGANSTSNVL 150 RDIA.....GNSTKLLEFGTRRAFSPQA---------.....-S.VLAARA.ALAGGMDATSNVL 151 ELMR.....EHRATFSIFGMRRRFSLEVEDRVTDILK.....QY.A-----.--GESLFGTSNVH 152 ELSN.....QHQLRFSEFGTRRRFSIDVQETVIKRLN.....DT.A-----.---KYCTGTSNCY 153 KISI.....-NQKTLAEFGCRRAQGPDG---------.....-A.LSGSRY.AY-AGADFTSNVY 154 RDIA.....GEQATLLEFGTRRAFSPQA---------.....-S.LWAARA.ALAGGLDATSNVL 155 KFSI.....-NNKTLAEFGCRRAQGPDG---------.....-A.LSGSKY.SFC-GCDFTSNVY 156 RDIA.....GESATLLEFGTRRAFSPQG---------.....-S.LWAARA.ALAGGLDSTSNVL 157 RQVA.....-EERALVDFGFRRAAGLA----------.....-S.YYASRA.AVIGGFDATSHVA 158 TLAA.....-SGRRLVDFGLRRAHGAEA---------.....-G.LLAARA.SYLAGFQASATVL 159 TLMEe14ldAKGCIFSEFGTRRRRGFKLHDKVVEVLH.....E-.------.--LDSFSGTSNVY 160 RDIA.....GEKAILLEFGTRRAFSPQG---------.....-A.IWAARA.ALGAGFDATSNVL 161 VAAA.....-RGRPVVDFGARRAHGTDA---------.....-A.CKVART.SYLAGAAGTSNLL 162 ASAA.....-KDRPCMDMGGRRTNEWA----------.....-A.VAAARA.AVVGGFKGTANLL 163 TRAA.....-DPVKVLAFGSRRAHGFDS---------.....-A.VEGNKA.AIIGGCYGHSNLV 164 ASAA.....-KDRPCMDMGGRRTNEWA----------.....-A.VAAARA.AVVGGFKGTANLL 165 RQLV.....GEEVDLLEFGTRRAFSPQA---------.....-S.LWAARS.ALAAGFTATSNVL 166 PHAA.....GPKRKLLEMGLRRAQGPDGGLTASRYTYi32trAR.VRADGG.TWPSGFDLTSNVQ 167 VTAA.....-DGRPIIEMGSRRTHEYS----------.....-A.VTASRA.AYLAGFSTTSNLE 168 VTAA.....-DGRPIIEMGSRRTHEYA----------.....-A.VTSSRA.AYLAGFSATSNLE 169 DKLEre7eeMNEFNLIDFGTRRRFSLAVQDAVVGRLK.....ER.L-----.---PAFRGTSNYL 170 TRAA.....-EPIKVLAFGSRRAHGFDS---------.....-A.VEGNKA.AIIGGCYGHSNLV 171 VTAA.....-DGRTIIEMGSRRTHEYA----------.....-A.VTATRA.AYLAGFSATSNLE 172 ----.....------ADFGTRRRFSYKVQEQVVKVLT.....AE.F-----.--PARFVGTSNVH 173 RQAS.....GWKIQLLEFGLRRAQGPNG---------.....-G.LTASKY.CYIGGFDATSNVL 174 ----.....----------------------------.....--.------.------------- 175 ----.....-------------RPGPDG---------.....-G.LSASKY.SYIGGFDYTSNIL 176 ----.....----------------------------.....--.------.------------- 177 KKSL.....-GNIPFISFGIRRMHPAI----------.....-S.PMIDRS.SYIGGAAGVSGVL 178 ----.....----------------------------.....--.------.------------- 179 YKVL.....-GDIPFYSFGIRRMNPAI----------.....-S.PMIDRS.AYIGGASGVSGIL 180 ----.....----------------------------.....--.------.------------- 181 ----.....----------------------------.....--.------.------------- 182 EQLRe....HPNLRISHFGTRRRHSFLWQRLC-----.....--.------.------------- 220 230 240 250 260 | | | | | 1 FAKKYGVKPIGTVAHEWVMGVASI...SE.....DYLHANKNAMDCWINTFGA..K.....NAGL 2 YAMKHGLTPLGTMAHEYLQACQAL...GP.....RLRDSQIFGFEMWAKEYRG..D.....-LGI 3 FARLHNMTPLGTMAHEYLQACQAL...GP.....RLRDSQVYALERWAHEYRG..D.....-LGI 4 YAMKHDLTPLGTMAHEYLQACQAL...GP.....RLRDSQTYGFEMWAKEYRG..D.....-LGI 5 YAMKHGITPLGTMAHEYLQACQAL...GP.....RLRDSQIYGFEMWAKEYRG..D.....-LGI 6 FAMKHNMTPLGTMAHEYLQACQSL...GP.....RLRDSQVFALETWAREYRG..D.....-LGI 7 FAKKYGVKPIGTVAHEWVMGVASI...SE.....DYLHANKNAMDCWINTFGA..K.....NAGL 8 FAMKHNMTPLGTMAHEYLQACQSL...GP.....RLRDSQVFALETWAREYRG..D.....-LGI 9 LARRLSLTPMGTQAHEWFQAHQQI...SP.....DLANSQRAALAAWLEEYPD..Q.....-LGI 10 LARRLSLTPMGTQAHEWFQAHQQI...SP.....DLANSQRAALAAWLEEYPD..Q.....-LGI 11 LARRLSLTPMGTQAHEWFQAHQQI...SP.....DLANSQRAALAAWLEEYPD..Q.....-LGI 12 LARRLSLTPMGTQAHEWFQAHQQI...SP.....DLANSQRAALAAWLEEYPD..Q.....-LGI 13 LARRLSLTPMGTQAHEWFQAHQQI...SP.....DLANSQRAALAAWLEEYPD..Q.....-LGI 14 LAMRHGVLPLGTMGHEYLQACQAL...GP.....RLRDSQVFALEVWAKEYRG..D.....-LGI 15 LAREYDLKPIGTMAHEWLMAHQQL...GP.....RLVDSQQAALDCWVREYRG..Q.....-LGI 16 LAMRHGVLPLGTMGHEYLQACQAL...GP.....RLRDSQVFALEVWAKEYRG..D.....-LGI 17 LAREYDLKPIGTMAHEWLMAHQQL...GP.....RLVDSQQAALDCWVREYRG..Q.....-LGI 18 LAMRHGVLPLGTMGHEYLQACQAL...GP.....RLRDSQVFALEVWAKEYRG..D.....-LGI 19 FAKQYGLTPLGTMAHEYLQAFQAL...GP.....RLRDSQVAALESWAREYRG..D.....-LGI 20 FAKQYGYTPLGTMAHEYLQAFQAL...GP.....RLRDSQVAGLEAWAREYRG..D.....-LGI 21 FAKQYGYTPLGTMAHEYLQAFQAL...GP.....RLRDSQVAGLEAWAREYRG..D.....-LGI 22 FAKQYGYTPLGTMAHEYLQAFQAL...GP.....RLRDSQVAGLEAWAREYRG..D.....-LGI 23 LARQLDLKPLGTMAHEWIMAHQQL...GP.....RLIDSQIAALDCWVREYRG..L.....-LGI 24 FAKQYGLTPLGTMAHEYLQAFQAL...GP.....RLRDSQVAALDSWAREYRG..D.....-LGI 25 LARKLGITPIGTMAHEFFQAFQAL...GV.....RLRDFQKAALESWVQEYRG..D.....-LGI 26 LARRLALTPMGTQAHEWFQAHQQI...SP.....DLATSQRAALAAWLNEYPD..Q.....-LGI 27 LARRLALTPMGTQAHEWFQAHQQI...NP.....DLATSQRAALAAWLNEYPD..Q.....-LGI 28 LARQLDLKPLGTMAHEWIMAHQQL...GP.....RLIDSQIAALDCWVREYRG..L.....-LGI 29 LAQQLGLPPVGTQAHEWFQAHQQI...SP.....DLASSQREALQSWLKEYPN..Q.....-LGI 30 LSRELDMKPLGTMAHEWIMAHQQL...GP.....RLIDSQIAALDCWVREYRG..L.....-LGI 31 AGKLFGIPLRGTHSHAFVSSFMSL...DEi40fsETNQSELAAFISYALAFPN..S.....--FL 32 LAKKLGITPIGTMAHEFLQAFQAL...DV.....RLRNFQKAALESWVHEYRG..D.....-LGV 33 LAKKLGITPIGTMAHEFLQAFQAL...DV.....RLRNFQKAALESWVHEYRG..D.....-LGV 34 LAKKLGMTPIGTMAHEFMQAFQAL...DV.....RLRDSQKAALEAWVHEYRG..D.....-LGI 35 LAKKLGITPIGTMAHEFLQAFQAL...DV.....RLRNFQKAALESWVHEYRG..D.....-LGV 36 LARKLDLKPLGTMAHEWLMAHQQL...GP.....RLIDSQSAALDCWVREYRG..L.....-LGI 37 AGKLFNIPVKGTHAHAYITSFTGI...DEl37tdESSEGELAAMVSFAIAFPD..G.....--FM 38 AGKLFNIPVKGTHAHAYITSFSSI...GEl37teESSEGELAAMVSYAIAFPD..G.....--FM 39 AGKLFGIPLRGTHSHAYVSSFMST...DEi40fsETNQSELAAFTSYALAFPK..T.....--FL 40 LARTLALAPVGTQAHEWFQAHQQI...SP.....TLANSQRVALQVWLDEYPN..Q.....-LGI 41 LARTLALAPVGTQAHEWFQAHQQI...SP.....TLANSQRVALQVWLDEYPN..Q.....-LGI 42 AGWLFGIPIRGTHSHAFVSSFMGL...DDi40frETNLSELAAFTSYALAFPN..S.....--FL 43 FAKKYGVKPVGTVAHEWYMGIAAL...TD.....DYRNANKNAMDFWLNTFGS..E.....QAGL 44 LAMRFNIPPVGTVAHEWFMGVAAI...IG.....DYRSATEVALRHWVACFGN..K.....-LGI 45 AGKLFGIPLRGTHSHAYVSSFMST...DEi40fsETNQSELAAFTSYALAFPK..T.....--FL 46 AGKLYGIPVKGTQAHSFICSFSSP...DEl39qsEVSDGELTAFVAYAIAFPD..S.....--FL 47 LAMRFNIPPVGTVAHEWFMGVAAI...LG.....DYKQATEVALRHWVACFGN..K.....-LGI 48 LAMRFNIPPVGTVAHEWFMGNAAI...LG.....DYKSATEEALSRWVGCYGP..G.....VLGI 49 AGKLFGIPLRGTHSHAFVSSYMSL...DEi37fgETNQSELAAFISYAFAFPD..N.....--FL 50 LAWKLDIKPLGTMAHEWIMAHQQL...GP.....RLIDSQIAALDCWVREYRG..L.....-LGI 51 AGKLYGIPVKGTQAHSFICSFSSP...AEl39lsEVSDGELSAFVAYAIAFPD..T.....--FL 52 AGKLYGIPVKGTQAHSFICSFSSP...AEl39lsEVSDGELSAFVAYAIAFPD..T.....--FL 53 AGKLYGIPVKGTQAHSFICSFSSP...AEl39lsEVSDGELSAFVAYAIAFPD..T.....--FL 54 AGKLYGIPVKGTQAHSFICSFSSP...AEl39lsEVSDGELSAFVAYAIAFPD..T.....--FL 55 IARILKIKPVGTQAHEWFQAHQQI...GS.....NLKNSQILALQKWLYQYKN..H.....-LGI 56 FAMKYDLPPIGTVAHEWYMGIASI...TQ.....DYVHANKLAMDYWIDTFGA..K.....YAGL 57 AGKKFGIPVSGTHAHALVQYY---...--.....---MNDYDAFKAYATTHRD..-.....--CV 58 AGKLFGIPVSGTHAHAFVQTY---...--.....---GDEYVAFKKYAERHKN..-.....--CV 59 AGKLFGIPVSGTHAHAFVQTY---...--.....---GDEYVAFKKYAERHKN..-.....--CV 60 AGNLFGIPLRGTHSHAYVSSYMLA...ESlc6fgETNQSELAAFASYALGFPT..H.....--FL 61 AGKIFGIPISGTHAHALVQTY---...--.....---RNDYQAFKAYAETHHD..-.....--CV 62 AGKLFGIPVSGTHAHAFVQTY---...--.....---GDEYVAFKKYAERHKN..-.....--CV 63 AGKLFNIPISGTHAHALVQAY---...--.....---HNDYDAFHAYAATHKN..-.....--VV 64 AGKIFGIPVSGTHAHSLVQSY---...--.....---GNDYEAFMAYAKTHRD..-.....--CV 65 AHCFFGIPIRGTHAHSFITNYSGP...DEl30ytATNLSELVAFVAYARTFPN..G.....--LV 66 AGKLFNIPVKGTHAHAYITSFTGI...DEl37tdESSEGELAAMVSFAIAFPD..G.....--FM 67 AGKLFNIPVKGTHAHAYITSFTGI...DEl37tdESSEGELAAMVSFAIAFPD..G.....--FM 68 AGKLFGIPVSGTHAHAFVQTY---...--.....---GDEYVAFKKYAERHKN..-.....--CV 69 AGNLFGIPLRGTHSHAYVSSYMLA...ESlc6fgETNQSELAAFASYALGFPT..H.....--FL 70 FAMKYDVDPVGTVAHEWYMTIAAI...TD.....DYENANEMALKYWLGCFGE..G.....VLGI 71 AGKIFGIPASGTHAHSLVQSY---...--.....---GNDYEAFMAYAKTHKD..-.....--CV 72 ISRILKLLPVGTQAHEWFQAHQQI...SS.....NLRNSQTLALKTWLSQYNQ..H.....-LSI 73 LARELDLTPIGTVAHEWFMGHQAL...VN.....-VRDSQKIALQRWQKMFNG..A.....-LGI 74 AGKLFGIPVAGTHAHSLVEAF---...--.....---NNEYDAFKAYAETHKD..-.....--CV 75 AGKRYGIPLSGTQAHSWIQCF---...--.....---PDELEAFRAYARTFPD..Q.....--CL 76 AGKLFDIPVLGTHAHALVQVY---...--.....---GNDYEAFKAYAATHKN..-.....--CV 77 AGKLFDIPVAGTHAHSLVEAF---...--.....---NNEYDAFKAYAETHKD..-.....--CV 78 LAMDTDLEALGTNAHELPMVLAALaktDD.....ELRSAPYRVLQDWNRYYGG..N.....-LLI 79 LARTRNLTPFGTQAHEWFQAHQQL...TG.....ELADSQQLALNRWLQEYPD..S.....-LGI 80 AGKLFNIPVKGTHAHAYITSFSSI...GEl37teESSEGELAAMVSYAIAFPD..G.....--FM 81 AGKIFNIPVSGTHAHALVQTY---...--.....---GDDYQAFKAYAETHKD..-.....--CV 82 AAKIFGLKASGTHAHALVQSY---...--.....---GNDYEAFKAYAQTHKD..-.....--CV 83 AGQLRGVPVAGTLAHSFVTSFSGS...EVp38vqEPHPGERAAFVAYALAFPR..A.....--FQ 84 AGQLRGVPVAGTLAHSFVTSFSGS...EVp38vqEPHPGERAAFVAYALAFPR..A.....--FQ 85 AGKLFNIPVSGTHAHALVQTY---...--.....---GDEYIAFKKYAERHKN..-.....--CV 86 AGQLRGVPVAGTLAHSFVTSFSGS...EVp38vqEPHPGERAAFVAYALAFPR..A.....--FQ 87 LAMDTDLEALGTNAHELPMVLAALaktDD.....ELRSAPYRVLQDWNRYYGG..N.....-LLI 88 AGKRFGIPVSGTHAHALVQAY---...--.....---GNDYDAFMAYAKTHKD..-.....--CV 89 AGKRFDIPVSGTHAHALVQAY---...--.....---GNDYDAFMAYAKTHKD..-.....--CV 90 AGKRFGIPVSGTHAHALVQAY---...--.....---GNDYDAFMAYAKTHKD..-.....--CV 91 LAMRFNMAPVGTVAHEWFMGIAAI...IG.....DYRSASEEALARWVGAFGP..G.....VLAI 92 LAMDSDLEAVGTNAHELPMVVAALaqtNE.....ELAAAPYQVLKDWNRLYGG..N.....-LLI 93 LAMDSDLEAVGTNAHELPMVVAALaqtNE.....ELAAAPYQVLKDWNRLYGG..N.....-LLI 94 LAMDTDLEALGTNAHELPMVIAAL...TNndn..ELRKAPYQVLQDWNRYYGG..N.....-LLI 95 AGKRFGIPVAGTHAHSFVQAY---...--.....---RDEYVAFKKYAETHKK..-.....--CV 96 LAMDNDLEALGTNAHELPMVFAAL...ANsek..ELKQAPYKVLQDWQRYYGG..N.....-LLI 97 AGKRFGIPVAGTHAHSFVQAY---...--.....---RDEYVAFKKYAETHKK..-.....--CV 98 AGKRFGIPVAGTHAHSFVQAY---...--.....---RDEYVAFKKYAETHKK..-.....--CV 99 LAMDNDLEAVGTNAHELPMVAAAL...TRndr..ELAAAPYKVLQDWNQLYGG..N.....-LLI 100 AGKRFGIPVAGTHAHSFVQAY---...--.....---RDEYVAFKKYAETHKK..-.....--CV 101 LAMATDLEALGTNAHELPMVIAAL...TNndn..ELCKAPYQVLQDWNRYYGG..N.....-LLI 102 AGKLFGIPVSGTHAHALVQAY---...--.....---GNDYDAFMAYAGTHKD..-.....--CV 103 AGWLFGIPIRGTHSHAFVSSFMGL...DDi40frETNLSELAAFTSYALAFPN..S.....--FL 104 AGKRFGIPVAGTHAHSFVQAY---...--.....---RDEYVAFKKYAETHKK..-.....--CV 105 AGQLRGVPVAGTLAHSFVTSFSGS...EVp38eqEPHPGERAAFVAYALAFPR..A.....--FQ 106 FAKKYGVKPIGTVAHEWVMGVASI...SEl....DYLHANKNAMDCWINTFGA..K.....NAGL 107 LAMDTDLEALGTNAHELPMVLAALsssDE.....ELKASPYQVLKDWQSYYGG..N.....-LLI 108 ADRDFGVPASGTMAHSWVQLF---...--.....---PSELEAFRAYARVYPD..N.....--CV 109 LAQEFNLTPIGTVAHEWTMAHQAL...VA.....-IQHSQRVALDKWLEAFNG..S.....-LGI 110 LAQEFNLTPIGTVAHEWTMAHQAL...VA.....-VQHSQCVALDKWLEAFNG..S.....-LGI 111 FAAKYNLNVSGTVAHEWYMGIAAI...TQ.....NYKQANRIASLKWVQTFGT..S.....-LLI 112 AGKLFGIPLRGTHSHAFVSSFMSL...DEi15tc------------------K..D.....--FI 113 AGQLRGVPVAGTLAHSFVTSFSGS...EVp38eqEPHPGERAAFVAYALAFPR..A.....--FQ 114 AGQLRGVPVAGTLAHSFVTSFSGS...EVp38vqEPHRGERAAFVAYALAFPR..A.....--FQ 115 FAKKYGLKPIGTVGHEWIMGTSAL...IG.....-LRYANRFAFENWVEVYKG..D.....-LGI 116 FAKKYGLKPIGTVGHEWIMGTSAL...VG.....-LRYANRFAFENWIDVYNG..D.....-LGI 117 AEQMFGVPSIGTMAHSWVQLF---...--.....---PTEYDAFKAWAEVYPD..N.....--CV 118 LAMDNDLEAIGTNAHELPMVAAGLakdDE.....ELRWAPYRILDQWRQTYGG..N.....-LLI 119 AGKLFGIPVSGTHAHSMIQAY---...--.....---RDEYKAFMKYAERHKD..-.....--CV 120 AGQLRGVPVAGTLAHSFITSFLGS...EVp38erEPHLGERAAFVAYALAFPR..A.....--FQ 121 FAKKYGVKPIGTVGHEWIMGTSAL...VG.....-LRYANRFAFENWVDVYNG..D.....-LGI 122 AGRLYGIPVAGTMAHSYITSFSSL...EEv37tnLIREGELAAFLSYAIAYPQ..N.....--FL 123 ADQMFDIPAIGTMAHSWIQLF---...--.....---GDEYEAFKAWAVAYPD..N.....--CT 124 AGKRFNIPVSGTHAHALVQAY---...--.....---RDEYTAFKKYAETHKD..-.....--CV 125 AGRQFGIPVSGTHAHAWVESF---...--.....---PTELDAFRAYAEFYPD..S.....--TT 126 AGKTFGIPVRGTHAHSWIMAF---...--.....---SDELTAFRKYAEVFPD..S.....--CI 127 AGKIFGIPVSGTMAHAMVQAY---...--.....---RDELEAFRSYAKTHFD..S.....---I 128 AGKIFGIPVSGTMAHAMVQAY---...--.....---RDELEAFRSYAKTHFD..S.....---I 129 AGKIFGIPVSGTMAHAMVQAY---...--.....---RDELEAFRSYAKTHFD..S.....---I 130 AGKIFGIPVSGTMAHAMVQAY---...--.....---RDELEAFRSYAKTHFD..S.....---I 131 AGQLRGVPVAGTLAHSFVTSFSGS...EVp38vqEPHPGERAAFVAYALAFPR..A.....--FQ 132 AGQLRGVPVAGTLAHSFVTSFSGS...EVp38vqEPHPGERAAFVAYALAFPR..A.....--FQ 133 SEQMFGVNAVGTMAHSWVQLF---...--.....---DNEFEAFKAWADVYPE..N.....--CV 134 SEQMFNVPASGTMAHSWIQFF---...--.....---GDEFEAFKAYAEIYPD..A.....--CT 135 AGKLFGIPVKGTHAHSWIMAF---...--.....---PDELTAFRAYAEVFPD..T.....--CI 136 AGQLRGVPVAGTLAHSFITSFLGS...EVp38erEPHPGERAAFVAYALAFPR..A.....--FQ 137 AGREFGIPVVGTMAHSYVMIF---...--.....---DKEEDAFRAFAKLYPK..N.....--AI 138 FAQQFDLVPIGTVAHEWTMAIAAL...QG.....-YAHSNLKALQLWDAVYSA..Pdf9thDLTI 139 IAMRREVEAIGTNAHELPMVYSALattDE.....DLARAPYQVLADWHEEHDG..N.....-LRI 140 AGKIYNIPINGTMAHSWVQMF---...--.....---ENELEAFKAYVKIYPK..N.....--PV 141 AARKLGILPVGTMAHSFVLSVVDT...PEa75vyRANLTELSAFMIYAYTHPN..S.....--FV 142 AAKLYGIRPMGTMAHAWVMSF---...--.....---DSEEEAFERYAALYGS..A.....--SV 143 AAEKFGLTVAGTMAHSWIEAF---...--.....---PNELSAFEKWAELYPD..N.....--SS 144 FAREFDLKPIGTIAHEWFMGHQAL...VN.....-ERDSQQVALERWLTAFDG..M.....-LAI 145 AGYKYNIPVTGTMAHSWIMSF---...--.....---ETEEQAFREYAKTYPN..K.....--VS 146 AAKELGIPALGTMAHSWIMSF---...--.....---KSEEDAFQAYADMYPD..N.....--SI 147 AGYKYNIPVTGTMAHSWVMSF---...--.....---KSEEEAFWEYAKIYPN..N.....--VS 148 AGKLFGIPVRGTHAHAFVNSFSSL...DEi24enETNEGELTAFLSYAFAFPT..S.....--CL 149 AAKLFDIPVAGTMAHSWIEAF---...--.....---PDELTAFRKWAEQYPD..N.....--SA 150 AALKLGRKPVGTMAHSLVMAISAV...E-.....---GSEEDAFKSFQRYFPT..A.....---T 151 LAHKHGLRVSGTHPHEWIQFHGAI...YG.....-YKMANYVAMEDWINVYDG..D.....-LGT 152 FAMKYGMKMMGTHPHEWFMFHGAQ...FG.....-YKHANYMALENWVNVYDG..D.....-LGI 153 ASFLYDIPILGTMSHSFILSFKGD...QSv29ckNANESELLAFVAFAQINPK..M.....--FI 154 AALQLGQQPSGTMAHALVMALSAM...E-.....---GSEEQAFSAFHRYFPG..A.....---P 155 ASYLYDIPILGTMSHSFISSFHNT...EKl29ckYTNESELIAFSAFAQINPK..N.....--FI 156 AALQLGQQPSGTMAHALVMALSAI...E-.....---GTEEQAFSAFHRYFPG..A.....---P 157 AGRDYDIPVVGTMAHSFVQSY---...--.....---DDELSAFRDFAEGRPD..D.....--CV 158 AGAQFGIPLAGTMAHSFVQAH---...--.....---LDEAEAFEHFARSLPQ..S.....--VL 159 FAKKYGVRPIGTIGHEWIMGNSAL...VG.....-LRNANKFAFDNWVKVYKG..D.....-LSI 160 AAKELNQQPSGTMAHALVMAIKGL...S-.....---GSEDEAFMAFNRHFPG..A.....---T 161 AARQYGIPTFGTMAHSFVQAF---...--.....---DSEVAAFEAFARLYPA..-.....--TM 162 AAQLYGLKAIGTAAHCFTLVH---...--.....---DSERDAFESQIEALGK..N.....--TT 163 TEYKYGIPSNGTMSHSYIQAF---...-G.....VGAEAEKEAFVTFIKHRRQrkN.....NSLI 164 AAQLYGLKAIGTAAHCFTLVH---...--.....---DSERDAFESQIEALGK..N.....--TT 165 AAQQLGVVPVGTMAHSLVMAIATL...K-.....---GTEQDAFTVFLRSYPE..-.....--GA 166 AGFLFGIPVTGTMAHSYVTSFTSL...EEv38agRVHEGELAAFLSYAAAYPH..N.....--FL 167 AAYRYGIPASGTSAHAWTLLH--I...ND.....DGTPNEAAAFKAQVESLGV..D.....--TT 168 ASFRYGIPASGTSAHAWTLLH--I...ND.....DGTPNEAAAFRSQVDQLGV..E.....--TT 169 LAQKYGLPAVGTQAHEWFQAHQQL...GF.....PLEHSQRAALTSWLDEFTN..H.....-LGI 170 TEYKYGIPSNGTMSHSYIQAF---...-G.....VGAEAEKEAFVTFIKHRRQrkN.....NSLI 171 AVHRYGIPGSGTAAHAWTLLH--V...NE.....DGTPNEKSAFESQVRAQGT..G.....--TT 172 LARKLDIKPLGTMAHEWIMAHQQL...GP.....RLIDSQIAALDCWVREYRG..L.....-LGI 173 AGKLYGIPVKGTQAHSFICSFSS-...--.....-------------------..-.....---- 174 --------PLGTMAHEYLQACQAL...GP.....RLRDSQVFALENWAREYRG..D.....-LGI 175 AGKLYGIPVRGTVAHSFIMSFRSL...EEv37sdKPNRGELAAFVSYAIAFPQ..D.....--FQ 176 ------------------------...--.....-LRDFQKAALESWVHEYRG..D.....-LGI 177 SSKILGIKPSGTMPHALSLILGDH...D-.....-----------AWKVQHDN..A.....SFRV 178 ------------------------...--.....ESSEGELAAMVSFAIAFPD..G.....--FM 179 GASLIGIKPVGTMPHALSIILGDD...A-.....-----------AWESVYKN..S.....DVKT 180 ------------------------...--.....EPHPGERAAFVAYALAFPR..A.....--FQ 181 -------------AHSYVTSFTCL...EEv38srRIHEGELAAFLSYAIAYPQ..N.....--FL 182 ------------------------...--.....-------------------..-.....---- 270 280 290 300 310 | | | | | 1 ALTDTFGTD.....DFLKSFRPP.....YSDA.....YVGVRQDS.....GDPVEYTKKISHHYH 2 ALSDVYGME.....AFLRDFDMY.....FCKL.....FDGARHDS.....GDPFDWGERLLKHYE 3 ALSDTYGFD.....AFLRDFDLY.....FCKL.....FDGVRHDS.....GDPFEWGERMIAHYA 4 ALSDVYGMD.....AFLNDFDMY.....FCKL.....FDGARHDS.....GDPFDWGERMLRHYE 5 ALSDVYGMD.....AFLNDFDMY.....FCKL.....FDGARHDS.....GDPFEWGERMLRHYE 6 ALSDTYGFD.....AFLRDFDMF.....FCKL.....FDGVRHDS.....GDPFEWGERMLKHYE 7 ALTDTFGTD.....DFLKSFRPP.....YSDA.....YVGVRQDS.....GDPVEYTKKISHHYH 8 ALSDTYGFD.....AFLRDFDMF.....FCKL.....FDGVRHDS.....GDPFEWGERMLKHYE 9 ALTDCITMD.....AFLRDFGVE.....FASR.....YQGLRHDS.....GDPVEWGEKAIAHYE 10 ALTDCITMD.....AFLRDFGVE.....FASR.....YQGLRHDS.....GDPVEWGEKAIAHYE 11 ALTDCITMD.....AFLRDFGVE.....FASR.....YQGLRHDS.....GDPVEWGEKAIAHYE 12 ALTDCITMD.....AFLRDFGVE.....FASR.....YQGLRHDS.....GDPVEWGEKAIAHYE 13 ALTDCITMD.....AFLRDFGVE.....FASR.....YQGLRHDS.....GDPVEWGEKAIAHYE 14 ALSDVYGMD.....AFLRDFDMY.....FCKL.....FDGARHDS.....GDPFVWGERLLEHYR 15 ALTDCITMD.....AFLDDFDLY.....FAKL.....FDGLRHDS.....GDPLAWAEKAIAHYR 16 ALSDVYGMD.....AFLRDFDMY.....FCKL.....FDGARHDS.....GDPFVWGERLLEHYR 17 ALTDCITMD.....AFLDDFDLY.....FAKL.....FDGLRHDS.....GDPLAWAEKAIAHYR 18 ALSDVYGMD.....AFLRDFDMY.....FCKL.....FDGARHDS.....GDPFVWGERLLEHYR 19 ALSDVVGLD.....AFLRDFDLY.....FCKL.....FDGMRHDS.....GDPFEWGERVIAHLE 20 ALSDVVGLD.....AFLGDFDLY.....FCKL.....FDGMRHDS.....GDPFKWGERIIMHLE 21 ALSDVVGLD.....AFLGDFDLY.....FCKL.....FDGMRHDS.....GDPFKWGERIIMHLE 22 ALSDVVGLD.....AFLGDFDLY.....FCKL.....FDGMRHDS.....GDPFKWGERIIMHLE 23 ALTDCITTD.....AFLNDFDLY.....FAKL.....FDGLRHDS.....GDPVKWAEKCISHYQ 24 ALSDVVGLD.....AFLRDFDLY.....FCKL.....FDGMRHDS.....GDPFDWGERVIAHLE 25 ALTDVVGMD.....AFLADFDLY.....FAKL.....FDGLRHDS.....GDPYIWGEKAIAHYR 26 ALTDCITMD.....AFLRDFGIE.....FASR.....YQGLRHDS.....GDPVAWGEKAIAHYE 27 ALTDCITMD.....AFLRDFGIE.....FASR.....YQGLRHDS.....GDPVAWGEKAIAHYE 28 ALTDCITTD.....AFLNDFDLY.....FAKL.....FDGLRHDS.....GDPVKWAEKCISHYQ 29 ALTDCITMD.....AFLRDFDAQ.....FAKN.....YQGLRHDS.....GDPVQWGEKAIAHYQ 30 ALTDCITTD.....AFLGDFDLF.....FAKL.....FDGLRHDS.....GDPVLWGEKCIAHYH 31 ALVDTYDVMk....SGIPNFCAVal6neLGYK.....AVGIRLDS.....GDLAYLSTEVRKFFC 32 ALTDVVGMD.....AFLRDFDLY.....FAKL.....FDGLRHDS.....GDPYIWGDKAYAHYQ 33 ALTDVVGMD.....AFLRDFDLY.....FAKL.....FDGLRHDS.....GDPYIWGDKAYAHYQ 34 ALTDVVGMD.....AFLRDFDLY.....FAKL.....FDGLRHDS.....GDPYLWGDKAIAHYK 35 ALTDVVGMD.....AFLRDFDLY.....FAKL.....FDGLRHDS.....GDPYVWGDKAYAHYQ 36 ALTDCITTD.....AFLRDFDLY.....FAKL.....FDGLRHDS.....GDPLLWAEKTIAHYL 37 ALVDTYDVKr....SGLLNFCAVal6ndQGYR.....AIGIRIDS.....GDLAYLSCLARETFE 38 ALVDTYDVKr....SGLLNFSAVal6ndLGYH.....ALGIRIDS.....GDLAYLSCLARETFE 39 ALVDTYDVMk....SGIPNFCAVal6ndFGYK.....ALGIRLDS.....GDLAYLSREARNFFC 40 ALTDCITMD.....AFLRDFDLA.....FANR.....YQGLRHDS.....GDPIEWGEKAIAHYE 41 ALTDCITMD.....AFLRDFDLA.....FANR.....YQGLRHDS.....GDPIEWGEKAIAHYE 42 ALVDTYDVMr....SGVPNFCAVal6ndMGYK.....AAGIRLDS.....GDLAYLSVETRKFFR 43 VLTDTFGTD.....TFLPMFRPP.....YSDV.....YDGVRQDS.....GDPAVFTEKVAHHYL 44 ALTDTFGTQ.....EFLRAFTQPv22ktYAET.....FAGIRQDS.....GDPAEYTKWMKEFYD 45 ALVDTYDVMk....SGIPNFCAVa23vlRRYK.....ALGIRLDS.....GDLAYLSREARNFFC 46 ALIDTYDVLr....SGVINFVAVsl6hdLGYR.....SMGCRIDS.....GDLSYLSRELRVRFV 47 ALTDTFGTQ.....EFLRAFTQTv22ktYAEA.....FAGIRQDS.....GDPAEYTKWMREFYD 48 ALTDTFGTP.....EFLRAFSKPm38ktYAQV.....FTGVRQDS.....GDPKEFVKLMRKFYD 49 ALVDTYDVMr....SGIPNFCAVal6gdLGYK.....AGGIRLDS.....GDLAYLSCQARKFFC 50 ALTDCITMD.....AFLGDFDLY.....FAKL.....FDGLRHDS.....GEPVAWAEKAIAHYQ 51 ALIDTYDVIr....SGVVNFVAVsl6hdLGYR.....SMGCRIDS.....GDLSYLSKELRECFV 52 ALIDTYDVIr....SGVVNFVAVsl6hdLGYR.....SMGCRIDS.....GDLSYLSKELRECFV 53 ALIDTYDVIr....SGVVNFVAVsl6hdLGYR.....SMGCRIDS.....GDLSYLSKELRECFV 54 ALIDTYDVIr....SGVVNFVAVsl6hdLGYR.....SMGCRIDS.....GDLSYLSKELRECFV 55 ALTDSITMD.....AFLDDFNLH.....FASF.....YQGIRHDS.....GDPVKWGEKALKHYE 56 ALTDTFGTD.....NYLTMFVAP.....YVNE.....YSGVRQDS.....GDPELYAEKIARHYE 57 FLVDTFDTLk....SGVPNAIRVakemgDKIN.....FLGVRIDS.....GDMAYLSKRVREQLD 58 FLVDTFHTLk....SGVPNAIKVakelgDKIN.....FVGIRLDS.....GDIAYLSKEARRMLD 59 FLVDTFHTLk....SGVPNAIKVakelgDKIN.....FVGIRLDS.....GDIAYLSKEARRMLD 60 ALVDTYDVMr....SGIPNFCAVal6hdLGYK.....ASGIRLDS.....GDLAYLSIEARKVFR 61 FLVDTYDTLr....SGVPSAIRVakemgDKIN.....FQGVRIDS.....GDMAYLSKRVREQLD 62 FLVDTFHTLk....SGVPNAIKVakelgDKIN.....FVGIRLDS.....GDIAYLSKEARRMLD 63 FLVDTFDTLk....SGVPNAIKVarefgDKIN.....FQGVRIDS.....GDMAYLSKKVRIMLD 64 FLVDTYDTLk....AGVPSAIRVaremgDKIN.....FLGVRIDS.....GDMAYISKRVREQLD 65 ALVDTYDTLa....SGVPNFICVal6hqLGYK.....AVGIRLDS.....GDLSYLSKASRKLFK 66 ALVDTYDVKr....SGLLNFCAVal6ndQGYR.....AIGIRIDS.....GDLAYLSCLARETFE 67 ALVDTYDVK.....RYSASRLYSl115dQGYR.....AIGIRIDS.....GDLAYLSCLARETFE 68 FLVDTFHTLk....SGVPNAIKVakelgDKIN.....FVGIRLDS.....GDIAYLSKEARRMLD 69 ALVGTYDVMr....SGIPNFCAVal6hdLGYK.....ASGIRLDS.....GDLAYLSIEARKVFR 70 ALTDTFGTP.....AFLDAFRKPi52ktYAQV.....YAGVRQDS.....GDPSYFVKMARDFYD 71 FLVDTYDTLk....SGVPSAIRVakelgDKIN.....FQGVRIDS.....GDMAYISKRVREQLD 72 ALTDCITMD.....SFLRDFNLF.....FSKS.....YQGIRHDS.....GDPVKWGEKAIEHYE 73 ALTDTIGID.....AFLKDFDEE.....LSHA.....YVGVRHDS.....GCPFTWGEKMIAHYE 74 FLVDTYDTLr....SGVPTAIKVakemgDKIN.....FQGVRIDS.....GDMAYISKKVRKQLD 75 LLVDTYNVLk....SGVPNAIKVgl6eaEGHR.....FLGIRIDS.....GDLTYLSREARKMLD 76 FLVDTYDTLr....IGVPAAIQVarelgDQIN.....FMGVRIDS.....GDIAYISKKVRQQLD 77 FLVDTYDTLr....SGVPTAIKVakemgDKIN.....FQGVRIDS.....GDMAYISKKVRKQLD 78 VLPDAFGTA.....AFLRNAPDW.....VAD-.....WTGFRPDS.....APPIEGGERIIEWWK 79 ALTDCINTD.....AFLRDFNSE.....LSER.....FVGLRHDS.....GDPITWGEKAIKHYE 80 ALVDTYDVK.....SRETEQANTe119dLGYH.....ALGIRIDS.....GDLAYLSCLARETFE 81 FLVDTYDTLr....VGVPNAIRVakemgEKIN.....FLGVRLDS.....GDLAYLSKKVRQQLD 82 FLVDTYDTLr....VGVPSAIKVarefgDKIN.....FQGVRIDS.....GDMAYISKKVRQQLD 83 GLLDTYSVWr....SGLPNFLAVal6geLGYR.....AVGVRLDS.....GDLLQQAQEIRKVFR 84 GLLDTYSVWr....SGLPNFLAVal6geLGYR.....AVGVRLDS.....GDLLQQAQEIRKVFR 85 FLVDTFHTLk....SGVPTAIKVakelgDTIN.....FIGIRLDS.....GDIAYLSKEARRMLD 86 GLLDTYSVWr....SGLPNFLAVal6geLGYR.....AVGVRLDS.....GDLLQQAQEIRKVFR 87 VLPDAFGTA.....AFLRNAPDW.....VAD-.....WTGFRPDS.....APPIEGGERIIEWWK 88 FLVDTYDTLk....VGVPTAIRVakemgDKIN.....FLGVRLDS.....GDLAYLSKTVRQQLD 89 FLVDTYDTLk....VGVPTAIRVakemgDKIN.....FLGVRLDS.....GDLAYLSKTVRQQLD 90 FLVDTYDTLk....VGVPTAIRVakemgDKIN.....FLGVRLDS.....GDLAYLSKTVRQQLD 91 ALTDTFGTP.....EFLKSFSRPv18ktYAQV.....FAGVRQDS.....GDPTTFVKRMREFYD 92 VLPDAFGTA.....AFLRNAPEW.....VAD-.....WTGFRPDS.....APPIEGGEKIIEWWR 93 VLPDAFGTA.....AFLRNAPEW.....VAD-.....WTGFRPDS.....APPIEGGEKIIEWWR 94 VLPDTFGTE.....AFLRNAPDW.....VAD-.....WTGFRPDS.....APPLEGGERIIQWWR 95 FLVDTYDTLk....SGVPNAIRVakefgDR--id...FYGIRLDS.....GDMAYLSKKARKLLD 96 VLPDAFGTA.....SFLRDAPDW.....VAD-.....WTGFRPDS.....APPIEGGEKILSWWR 97 FLVDTYDTLk....SGVPNAIRVakefgDR--id...FYGIRLDS.....GDMAYLSKKARKLLD 98 FLVDTYDTLk....SGVPNAIRVakefgDR--id...FYGIRLDS.....GDMAYLSKKARKLLD 99 VLPDAFGTA.....AFLRDAPDW.....VAD-.....WTGFRPDS.....APPIEGGEKIIAWWK 100 FLVDTYDTLk....SGVPNAIRVakefgDR--id...FYGIRLDS.....GDMAYLSKKARKLLD 101 VLPDTFGTE.....TFLRNAPDW.....VAD-.....WTGFRPDS.....APPIEGGERIIQWWK 102 FLVDTYDTLr....LGVPAAIRVaselgDKIN.....FLGVRIDS.....GDMAYLSKKVRKLLD 103 ALVDTYD--.....---------.....----.....AAGIRLDS.....GDLAYLSVETRKFFR 104 FLVDTYDTLk....SGVPNAIRVakefgDR--id...FYGIRLDS.....GDMAYLSKKARKLLD 105 GLLDSYSVRr....SGLPNFLAVal6geLGYR.....AVGVRLDS.....GDLLQQAKEIRGIFR 106 ALTDTFGTD.....DFLKSFRPP.....YSDA.....YVGVRQDS.....GDPVEYTKKISHHYH 107 VLPDTFGTE.....SFLEDAPGW.....VAD-.....WTGFRPDS.....APPIEGGERIISWWE 108 LLVDTYNVLk....SGVPNAIKVfk7vpRGFR.....PKGIRIDS.....GDIAYLSKEARKMLD 109 ALTDTIGID.....AFLSDFDLD.....KATA.....YAGVRHDS.....GSPFVWGDKIIAHYE 110 ALTDTIGID.....AFLSDFDLE.....KATA.....YAGVRHDS.....GSPFVWGDKIIAHYE 111 ALTDTFSTD.....VFLKSFTANsadd.LANV.....FHGVRQDS.....GCAEEYIEKVVKHYK 112 CLVQTCLTKiqvmkSGIPNFCAVal6neLGYK.....AVGIRLDS.....GDLAYLSTEVRKFFC 113 GLLDSYSVRr....SGLPNFLAVal6geLGYR.....AVGVRLDS.....GDLLQQAKEIRGIFR 114 GLLDTYSVRr....SGLPNFLAVal6qeLGYQ.....AVGVRLDS.....GDLLQQAREIRGVFR 115 ALTDTFGSE.....AFFKDMDLK.....LSKI.....YDGFRHDS.....GDPFTFVDRVIDHYR 116 ALTDTFGSK.....AFFKDMDLR.....LSKT.....YDGFRHDS.....GDPYDFVDAVIEHYR 117 FLVDTYNVLk....SGIPNAIKVfn7kpMGYR.....PKAVRIDS.....GDITYLSKKCREMLD 118 ALPDAFGTK.....AFLRDAPEW.....VAD-.....WTGFRPDS.....APPIQAGEEIIAWWE 119 FLVDTYDTLr....SGVPNAIKAakelgDSIN.....FQGIRLDS.....GDLAYLSKEARRMLD 120 GLLDSYSVRr....SGLPNFLAVal6geLGYR.....AVGVRLDS.....GDLLQQAKEIRGIFR 121 ALTDTFGSE.....AFFKDMDLK.....LSKI.....YDGFRHDS.....GDPYTFVDRVIEHYG 122 PVIDSYSVRc....SGLLCFCAVal6feLQYR.....PLGVRLDS.....GDLCRQSLDVRRVFR 123 LLIDTYNVLk....SGVPNAIKVfd7kpLGKR.....PKGIRIDS.....GDITYLSKKCRQMLD 124 FLVDTYDTLr....SGMPNAIRVakefgDRIN.....FIGIRLDS.....GDLAYLSKKARKMLD 125 LLLDTVDTLg....SGLPNALTVaa6raKGHE.....LGGVRVDS.....GDLAYLSRVIRERLD 126 LLVDTYDTLr....SGLPNAITVar6raKGHE.....LVGVRIDS.....GDLAYLSRQARRLFD 127 FLVDTYDTLk....SGVPNAIKVakemgDKIN.....FIGIRLDS.....GDMAFLSKKARQMLD 128 FLVDTYDTLk....SGVPNAIKVakemgDKIN.....FIGIRLDS.....GDMAFLSKKARQMLD 129 FLVDTYDTLk....SGVPNAIKVakemgDKIN.....FIGIRLDS.....GDMAFLSKKARQMLD 130 FLVDTYDTLk....SGVPNAIKVakemgDKIN.....FIGIRLDS.....GDMAFLSKKARQMLD 131 GLLDTYSVWr....SGLPNFLAVal6geLGYR.....AVGVRLDS.....GDLLQQAQEIRKVFR 132 GLLDTYSVWr....SGLPNFLAVal6geLGYR.....AVGVRLDS.....GDLLQQAQEIRKVFR 133 LLVDTYNVLk....SGLPNAIKVfd7kpKGIR.....PSGIRIDS.....GDITYLTKKCRKILD 134 LLVDTYNVLe....SGIPNAIKVak7epMGKR.....LKGIRLDS.....GDLAYLSKKVRKILN 135 LLVDTYDTLk....SGIPNAITVaq6rsQGHE.....LVGVRIDS.....GDLAYLSREGRRMFD 136 GLLDSYSVRr....SGLPNFLAVal6geLGYR.....AVGVRLDS.....GDLLQQAKEIRGIFR 137 FLIDTYDTI.....EAAKKVVDLak...EGVP.....VVGVRIDS.....GDIVKLSKEVRKILD 138 ALTDTFSTN.....VFWNDLLDNpsgieIARR.....WRGLRQDS.....GDSKAFAQKALDAYR 139 ILPDTYGTE.....GFLARAPDW.....LST-.....WTGIRIDS.....GDPAQGAETAIRWWQ 140 FLIDTYDCLn....SGLKNAIKVfke..FGIQ.....EGGVRIDS.....GNLLELSLKIRQELD 141 ALIDTYDSLn....SGLYNFLIVac6ieCSVQ.....PRGVRLDS.....GDLSFLSIEIKRAFS 142 FLIDTYHTLe....SGIQNAIAIgtrlkAAGK.....SFGVRLDS.....GDMQYLSVQVRAALD 143 LLVDTYDVVs....SGVPNAIKVfq6eeKGHK.....PIGIRIDS.....GDIAHLSKLARKMLD 144 APTDTLTID.....AFLNDFNRH.....LANA.....YDGVRHDS.....GCPFRWGDKMIAHYQ 145 LLIDTYDTLn....SGLKNAIKI.....FKELkh6knNFSIRIDS.....GDLEYLSKAARKELN 146 FLIDTYDTLr....SGIVNAIKVgkrlqEKGK.....NFGVRLDS.....GDIYYLSKDVRKRLD 147 LLIDTYDTLn....SGLKNAIKVfk6krKGHK.....NFSVRIDS.....GDLEYLSKEVRKILN 148 CLLDTYSVIk....SGLPNFLAVal6ndYGYR.....VIGVRLDS.....GDLAYLSRKCREGFN 149 LLVDTYDVLn....SGIPNAVTVfk6raAGHE.....PVGIRIDS.....GDVTTLSQAARTQLD 150 LLIDTYDTLsat..RLLARRVKQ.....GEMQ.....ISGVRLDS.....GNLVELSQKVRSLLP 151 VLTDTYTTD.....VFMRNFSKK.....HAML.....FTSLRHDS.....GDPEIFIEKAVRRYE 152 ALSDTYTSG.....IFLSNLSRK.....QAKL.....FDGVRCDS.....GNEFDFIDKLVARYK 153 SLIDTYSTLe....SGIFNFLIVal6heINYK.....PIGIRIDS.....GDLKHLSNECKKIFI 154 LLIDTYDTIaaa..QHLAEKVNT.....GKME.....LSGVRLDS.....GDLVSLSKQVRSLLP 155 CLIDTYDTLk....SGIYNFLIVal6yeINYK.....PIGIRIDS.....GDLRSLTNECKNIFN 156 LLIDTYDTI.....AAAGRLAEKvns..GEMQ.....LTGVRLDS.....GDLVTLSKQVRSLLP 157 LLVDTYDTLk....SGMPNAIKIak6eaRGQR.....LKGVRLDS.....GDLAYLAKKSRQMLD 158 LLIDTYDTE.....AAARKVVELap6aaAGIR.....VQGVRLDS.....GDLGEHARRVRAILD 159 ALSDTFGSK.....PFFQNFSIG.....LAKI.....YDGVRHDS.....GDPIKFADEVIEHYK 160 LLIDTYDTL.....AAAQRLAEN.....REIE.....IKGVRVDS.....GDLGSLSQKVRSLLP 161 LLVDTYDTL.....RGVDHVIELakr..---LgnrfdVRAVRLDS.....GDLDELSKATRARLD 162 LLVDTYNIE.....EAVKTAVEV.....AGPE.....LGGVRIDS.....GDLAAMAQRVRNQLD 163 LLVDTYDTIh....IGIENAIKA.....FKECgi8egVYGVRLDS.....GDLAYQSKKCRKRFD 164 LLVDTYNIE.....EAVKTAVEV.....AGPE.....LGGVRIDS.....GDLAAMAQRVRNQLD 165 LLVDTYDSLaai..ATLADRQAA.....GEIL.....VKAVRIDS.....GDLLSLSQKIRQLLP 166 SVIDSYSVGc....SGLLNFCAVal6ceLGYR.....PVGVRLDS.....GDLCSLSVDVRRVFR 167 LLVDTYDIT.....QGVATAIEV.....AGPD.....LGGVRIDS.....GDLGVLARKVRKQLD 168 LLVDTYDIA.....RGVETAIEV.....AGTD.....LGGVRIDS.....GDLGVLARQVRQQLD 169 ALTDCITMD.....AFLRDFDFE.....LASR.....YQGLRHDS.....GDPVVWGEKAISHYQ 170 LLVDTYDTIh....IGIENAIKA.....FKECgi8egVYGVRLDS.....GDLAYQSKKCRKRFD 171 LLIDTYDIA.....QGVRNAIEV.....AGPE.....LGAVRIDS.....GDLGVMTRKIRQELD 172 ALTDCITMD.....AFLGDFDLY.....FAKL.....FDGLRHDS.....GDPVQWAEKAIAHYR 173 ---------.....---------.....----.....--------.....--------------- 174 ALSDTYGFD.....AFLRDFDLF.....FCKL.....FDGVRHDS.....GDPFLWGEKMLAHYA 175 GLLDTYCVMr....SGLPNFCAVal6hqLGYR.....AIGVRLDS.....GNLIQQSKETRRVLR 176 ALTDVVGMD.....AFLNDFDLY.....FAKL.....FDGLRHDS.....GDPYEWGDKAYAHYQ 177 FLIDTFMDE.....KFAAIKAAD.....EFPD.....IDFIRLDTpssrrGNFPNLIREIRWELD 178 ALVDTYDVKr....SGLLNFCAVal6ndQGFR.....AVGIRIDS.....GDLAYLSCLARETFE 179 ILIDTFMDE.....KFAAIKAAE.....KFPG.....LDYIRLDTpasrrGNFKNIVRELRWELN 180 GLLDTYSVWr....SGLPNFLAVal6geLGYR.....AVGVRLDS.....GDLLQQAQEIRKVFR 181 SVIDSYSVG.....CGLLNFCAVal6ceLGYR.....PVGVRLDS.....GDLCSLSVDVRQVFR 182 ---------.....---------.....----.....--------.....--------------- 320 330 340 350 360 | | | | | 1 DV.....LKLPKFSKIICYSDSLNVEKAITYSHAAKENGMLATFGIGTNFTNDFRK.....KSEP 2 A-.....NRCDPRTKILVFSDALDIPKVLQLYERF-RGRCKLAFGVGTNLTNDL--.....---- 3 A-.....NRVDPRGKTLIFSDALDIPKVIELYERF-RGRCKLAFGVGTNLTNDL--.....---- 4 A-.....NRCDPRTKVLVFSDALDIPKVMQLYERF-RGRCKLAFGVGTNLTNDL--.....---- 5 S-.....NRCDPRTKVLVFSDALDIPKVMQLYERF-RGRCKLAFGVGTNLTNDL--.....---- 6 G-.....MRVDPQSKALIFSDSLDMPKVVRLYERF-RSRCKLAFGVGTNLTNDL--.....---- 7 DV.....LKLPKFSKIICYSDSLNVEKAITYSHAAKENGMLATFGIGTNFTNDFRK.....KSEP 8 G-.....MRVDPQSKALIFSDSLDMPKVVRLYERF-RSRCKLAFGVGTNLTNDL--.....---- 9 K-.....LGIDPQSKTLVFSDNLDLRKAVELYRHF-SSRVQLSFGIGTRLTCDI--.....---- 10 K-.....LGIDPQSKTLVFSDNLDLRKAVELYRHF-SSRVQLSFGIGTRLTCDI--.....---- 11 K-.....LGIDPQSKTLVFSDNLDLRKAVELYRHF-SSRVQLSFGIGTRLTCDI--.....---- 12 K-.....LGIDPQSKTLVFSDNLDLRKAVELYRHF-SSRVQLSFGIGTRLTCDI--.....---- 13 K-.....LEIDPQSKTLVFSDNLDLRKAVELYRHF-SSRVQLSFGIGTRLTCDI--.....---- 14 A-.....NRADPRAKTLVFSDSLTFPRAIELARQF-AGRCKVSFGIGTNLTNDL--.....---- 15 R-.....LGIDPLSKTLVFSDGLDMPKALQLFRAL-RGKINVSFGIGTNLTCDI--.....---- 16 T-.....NRADPRAKTLVFSDSLTFPRAIELARQF-AGRCKVSFGIGTNLTNDL--.....---- 17 R-.....LGIDPLSKTLVFSDGLDMPKALQLFRAL-RGKINVSFGIGTNLTCDI--.....---- 18 A-.....NRADPRAKTLVFSDSLTFPRAIELARQF-AGRCKVSFGIGTNLTNDL--.....---- 19 A-.....HRVDPRTKVLVFSDGLNIDKVMRLYQHF-HTRCRLAFGVGTSLTNDL--.....---- 20 S-.....HRIDPRTKVLVFSDGLDMNKVMRLYQHF-RGRCRLAFGVGTSLTNDL--.....---- 21 S-.....HRIDPRTKVLVFSDGLDMNKVMRLYQHF-RGRCRLAFGVGTSLTNDL--.....---- 22 S-.....HRIDPRTKVLVFSDGLDMNKVMRLYQHF-RGRCRLAFGVGTSLTNDL--.....---- 23 K-.....LGIDPMSKTLVFSDGLNLPKALDIFRAL-RGRINVSFGIGTNLTADI--.....---- 24 A-.....HRVDPRTKVLVFSDGLNIDKVMRLYEHF-SPRCRLAFGVGTSLTNDL--.....---- 25 K-.....LRIDPATKMLTFSDGLSVDSALQLQRHF-SPHIQVSFGIGTHFTNDM--.....---- 26 K-.....LGIDPLTKTLVFSDNLDLPKAVELYRHF-ASRVQLSFGIGTRLTCDI--.....---- 27 K-.....LGIDPLTKTLVFSDNLDLPKAVELYRHF-ASRVQLSFGIGTRLTCDI--.....---- 28 K-.....LGIDPMSKTLVFSDGLNLPKALDIFRAL-RGRINVSFGIGTNLTADI--.....---- 29 K-.....LGIDPMTKTLVFSDSLDFQKALALYRHF-HNRINLIFGIGTQLTCNI--.....---- 30 K-.....LGIDPMSKTLVFSDSLTLPKSLEIFRAL-RGRINVSFGIGTNLTCDI--.....---- 31 AIerdl.KVPDFGKMIVTASNDLNEETVDALNK---QGHEVDAFGIGTNLVTCY--.....---- 32 K-.....LKIDSRTKMLTFSDGLDIERSWALHQYF-KDRFKTGFGIGTNLTNDM--.....---- 33 K-.....LKIDSRTKMLTFSDGLDIERSWALHQYF-KDRFKTGFGIGTNLTNDM--.....---- 34 K-.....LKIDPRTKVLTFSDGLDLNKAWDLHQYF-KGQIKTSFGIGTNLTNDM--.....---- 35 K-.....LKIDSRTKMLTFSDGLDIERSWALHQYF-KDRFKTGFGIGTNLTNDM--.....---- 36 K-.....LGIDPLTKTLVFSDGLDLPRALKIYRAL-QGRINVSFGIGTHFTCDL--.....---- 37 RIaerf.KLPWFSKLTIVASNDINEDTILSLNE---QGHKIDCFGIGTHLVTCQ--.....---- 38 KVaerf.KVPWFNKLTIVASNDINEDTILSLNE---QGHKIDCFGIGTHLVTCQ--.....---- 39 TVerel.KVPGFGKMVVTASNDLNEETIDALNK---QGHEVDAFGIGTYLVTCY--.....---- 40 K-.....LGIDPMKKVLVFSDNLDLEKALFLYRHF-YQRIKLVFGIGTRLTCDI--.....---- 41 K-.....LGIDPMKKVLVFSDNLDLEKALFLYRHF-YQRIKLVFGIGTRLTCDI--.....---- 42 AIeeef.GFIGFGKMNITASNDLNEETIDALNK---QGHEVDAFGIGTYLVTCY--.....---- 43 NV.....LHYPRFSKVICYSDSLNPEKALQYAEVARAHGMRASFGIGTNFTNDFRR.....HSAP 44 K-.....-QGITDKKLIVFSDSLNIERCLEYKKIAEDLGFQPTFGVGTYLTNDFVH.....LTTG 45 TVerel.KVPGFGKMVVTASNDLNEETIDALNK---QGHEVDAFGIGTYLVTCY--.....---- 46 KVaalneDYKFFEKMCIVASNDINEETIMSLNE---QKHEINSFGVGTHLVTCQ--.....---- 47 K-.....-QGITDKKLIVFSDSLNIERCLEYKKVADDLGFQPTFGVGTYLTNDFTN.....TKTG 48 E-.....-QGIKDKKVIVFSDSLDIDRCLEYKEVAEAAGFQPTFGVGTYFTNDFVH.....KATG 49 SIekef.GVPGFGKLIITASNDLNEETLDALNK---QGHEVDAFGIGTYLVTCY--.....---- 50 K-.....LGIDPMTKTLVFSDGLNLTRSLEIFRAL-RGRINVSFGIGTNLTCDI--.....---- 51 KVstlkgEYKFFEKMSIVASNDINEETIMSLND---QQHEINAFGVGTHLVTCQ--.....---- 52 KVstlkgEYKFFEKMSIVASNDINEETIMSLND---QQHEINAFGVGTHLVTCQ--.....---- 53 KVstlkgEYKFFEKMSIVASNDINEETIMSLND---QQHEINAFGVGTHLVTCQ--.....---- 54 KVstlkgEYKFFEKMSIVASNDINEETIMSLND---QQHEINAFGVGTHLVTCQ--.....---- 55 K-.....LGIDPCTKTLLFSDNLDFKKIISLYKKF-HKKINVIFGIGTKLTCDI--.....---- 56 K-.....MGIAKNTKIICFSDSLNVEKCLKYKNTADKLGLISTFGIGTFFTNDFNK.....LSNG 57 E-.....--AGFPNAKIFASNDLDEKTIQNLKM---QGAKIEVWGVGTKLITAY--.....---- 58 E-.....--AGFTETKIIASNDLDEETITSLKA---QGAKVDSWGVGTKLITGY--.....---- 59 E-.....--AGFTETKIIASNDLDEETITSLKA---QGAKVDSWGVGTKLITGY--.....---- 60 TLekef.NVPAFGKMIITASNDLNEETIDALNK---QGHEVDSFGIGTYLVTCY--.....---- 61 E-.....--AGFPDAKIYASNDLDEKTIQNLKM---QGAKISVWGVGTKLITAF--.....---- 62 E-.....--AGFTETKIIASNDLDEETITSLKA---QGAKVDSWGVGTKLITGY--.....---- 63 E-.....--AGFTNAKIYASNDLDENTILNLKI---QGAKIDVWGIGTKLITAY--.....---- 64 E-.....--AGFTEAKIYASNDLDENTILNLKM---QKSKIDVWGVGTKLITAY--.....---- 65 QIgeqf.KIDYFEKFSIVASNDLNEPTIIALNR---QGHEIDVFAIGTNLVTCQ--.....---- 66 RIaerf.KLPWFSKLTIVASNDINEDTILSLNE---QGHKIDCFGIGTHLVTCQ--.....---- 67 RIaerf.KLPWFSKLTIVASNDINEDTILSLNE---QGHKIDCFGIGTHLVTCQ--.....---- 68 E-.....--AGFTETKIIASNDLDEETITSLKA---QGAKVDSWGVGTKLITGY--.....---- 69 TLekef.NVPAFGKMIITASNDLNEETIDALNK---QGHEVDSFGIGTYLVTCY--.....---- 70 R-.....-EGITGTKTVVFSDSLDIEHCLEYKVLAEEAGFKPVFGVGTFFTNDFIN.....TTTN 71 A-.....--AGFTEAKIYASNDLDEATILNLKM---QKAKIDVWGVGTKLITAY--.....---- 72 R-.....LGIDPTTKTLLFSDNLNFRKMISLYKKF-NNRVNIIFGIGTKLTCDI--.....---- 73 S-.....LGIDPMTKTLVFTDGLNFEQALDICEHF-QGRVQVSFGIGTSLANDMGN.....YVND 74 D-.....--AGFPDAKIYASNDLDEKTIQNLKM---QGAKIDVWGIGTKLITAF--.....---- 75 Q-.....--AGLEHARIVASNDLDEHTISAIRA---QGAAIDSWGVGTHLITSK--.....---- 76 E-.....--AGFTEAKIYASNDLDENTILNLKM---QKAKIDVWGVGTKLITAY--.....---- 77 D-.....--AGFPDAKIYASNDLDEKTIQNLKM---QGAKIDVWGIGTKLITAF--.....---- 78 S-.....KGKDPREKLLIFSDALDVDTIEETYRHF-EGRVRMGFGWGTNLTNDFAG.....CAPQ 79 S-.....LDIDLRTKSLIFSDSLTLDKALNIYKHF-ASRINVSFGIGTQLTCDL--.....---- 80 KVaerf.KVPWFNKLTIVASNDINEDTILSLNE---QGHKIDCFGIGTHLVTCQ--.....---- 81 D-.....--AGFPNAKIYASNDLDENTILNLKM---QKAKIDVWGVGTKLITAY--.....---- 82 E-.....--AGFTDAKIYASNDLDENTILSLKM---QKAKIDVWGVGTKLITAY--.....---- 83 AAaaqf.QVPWLESVLIVVSNNIDEEALARLAQ---EGSEVNVIGIGTSVVTCP--.....---- 84 AAaaqf.QVPWLESVLIVVSNNIDEEALARLAQ---EGSEVNVIGIGTSVVTCP--.....---- 85 E-.....--AGFTEAKIIASNDLDEQTITSLKA---QGAKVDGWGVGTKLITGY--.....---- 86 AAaaqf.QVPWLESVLIVVSNNIDEEALARLAQ---EGSEVNVIGIGTSVVTCP--.....---- 87 S-.....KGKDPREKLLIFSDALDVDTIEETYRHF-EGRVRMGFGWGTNLTNDFAG.....CAPQ 88 D-.....--AGFTEAKIYASNDLDENTILNLKM---QKAKIDVWGVGTKLITAY--.....---- 89 D-.....--AGFTEAKIYASNDLDENTILNLKM---QKAKIDVWGVGTKLITAY--.....---- 90 D-.....--AGFTEAKIYASNDLDENTILNLKM---QKAKIDVWGVGTKLITAY--.....---- 91 Q-.....-QRIKEKKTIVFSDSLDIDRCLVYKQVSEAAGFQPTFGVGTFLTNDFVG.....KSTG 92 K-.....MGRDPRTKMLIFSDGLDVDAIVDTYRHF-EGRVRMSFGWGTNLTNDFAG.....CAPK 93 K-.....MGRDPRTKMLIFSDGLDVDAIVDTYRHF-EGRVRMSFGWGTNLTNDFAG.....CAPK 94 E-.....KGKDPREKLLIFSDALDIDTIEKTYHHF-HGKVRMSFGWGTDLTNDFVG.....CSPQ 95 E-.....--AGFTNTKIIASSDLDEYTIMHLKS---QGAKIDVWGVGTKLITSF--.....---- 96 E-.....RGKDPKQKLLIFSDGLEVETIEETYRHF-KGKVRMSFGWGTNLTNDFEG.....CAPT 97 E-.....--AGFTNTKIIASSDLDEYTIMHLKS---QGAKIDVWGVGTKLITSF--.....---- 98 E-.....--AGFTNTKIIASSDLDEYTIMHLKS---QGAKIDVWGVGTKLITSF--.....---- 99 K-.....MGRDPREKLLIFSDGLDVDTIIRTYCHF-EGRVRMSFGWGTNLTNDFAG.....CAPT 100 E-.....--AGFTNTKIIASSDLDEYTIMHLKS---QGAKIDVWGVGTKLITSF--.....---- 101 E-.....KGKDPREKLLIFSDALDVNTIEQTYHHF-HGRVRMSFGWGTDLTNDFVG.....CAPQ 102 E-.....--AGYPHAKIYASNDLDENTILNLKM---QKAKIDIWGVGTKLITAY--.....---- 103 AIeeef.GFIGFGKMNITASNDLNEETIDALNK---QGHEVDAFGIGTYLVTCY--.....---- 104 E-.....--AGFTNTKIIASSDLDEYTIMHLKS---QGAKINVWGVGTKLITSF--.....---- 105 TAgaqf.QMPWLESVPIAVSNNIDESELMRLAQ---KGSEVNVIGIGTSVVTCP--.....---- 106 DV.....LKLPKFSKIICYSDSLNVEKAITYSHAAKENGMLATFGIGTNFTNDFRK.....KSEP 107 Q-.....HGRDPREKLLIFSDALDVDTIEQTYRHF-KGRSRLSFGWGTNLTNDFDG.....CAPE 108 E-.....--AGFPDCKIVVSNSLDEYIIRDILQ---QGAQVDIFGVGERLITSK--.....---- 109 S-.....LGIDPTTKTLIFTDGLDFARALDICEYF-AGRAQISFGIGTFLANDMGN.....WTND 110 S-.....LGIDPSTKTLIFTDGLDFARALDICEYF-AGRAQISFGIGTFLANDMGN.....WTND 111 S-.....IGVDPSTKVIVHSDALNVDRCIELYKYCEKCGIKSAFGIGTNLTSDFQK.....VSNP 112 AIerdl.KVPDFGKMIVTASNDLNEETVDALNK---QGHEVDAFGIGTNLVTCY--.....---- 113 TAgaqf.QMPWLESVPIAVSNNIDESELMRLAQ---KGSEVNVIGIGTSVVTCP--.....---- 114 TAaaqf.GVPWLQSVPIAVSNNIDEEELARLAQ---KGSEVNVIGIGTSVVTCP--.....---- 115 K-.....MGIDPMKKVIVFSDALNAEAAIRLKKYC-QDKINCSFGIGTSLTNNSEF.....FR-- 116 K-.....MGIDPMKKLLVFSDALNADTAIQLKKYC-EGKINCSFGIGTSLTNNSDF.....FR-- 117 E-.....--AGYEDVQITVSNSLDEYIIRSVLK---QGAPIDSFGVGERLITAR--.....---- 118 K-.....KGRNPRDKLLVFSDAMDVGSIEETYHHF-TGRVRLSFGWGTNLTNDFVG.....CAPD 119 E-.....--AGFPDAKIYASNDLDEYTIASLLA---QGAKIDVWGIGTKLITAY--.....---- 120 TVgaef.QMPWLEFVPIAVSNNIDEKELARLAQ---KGSEVNVIGIGTNVVTCP--.....---- 121 K-.....MGIDPMKKVIVFSDALNAEAAVKLKKYC-EGKINCSFGIGTSLTNNSEF.....FR-- 122 ECskhf.SVPQFESLIIVGTNSISEQSLSELNK---KDNEIDVVGVGTHLVTCT--.....---- 123 E-.....--AGYPDCKIIVSNSLDEYIIRDVLS---QGASIDAFGVGERLITAR--.....---- 124 E-.....--AGFTDAKVIASSDLDEHTIMNLKA---QGARIDVWGVGTKLITAY--.....---- 125 A-.....--AGFPDVKIVVSNDLSESVISGVIA---EGGRVDVYGVGTQLATAG--.....---- 126 E-.....--AGFPNVRIVASNELDEFVIESIRA---EGGCVDIYGVGTRLATCA--.....---- 127 E-.....--AGFTEAKIFASSDLDEHTILSLKA---QKAKIDSWGVGTKLITAY--.....---- 128 E-.....--AGFTEAKIFASSDLDEHTILSLKA---QKAKIDSWGVGTKLITAY--.....---- 129 E-.....--AGFTEAKIFASSDLDEHTILSLKA---QKAKIDSWGVGTKLITAY--.....---- 130 E-.....--AGFTEAKIFASSDLDEHTILSLKA---QKAKIDSWGVGTKLITAY--.....---- 131 AAaaqf.QVPWLESVLIVVSNNIDEEALARLAQ---EGSEVNVIGIGTSVVTCP--.....---- 132 AAaaqf.QVPWLESVLIVVSNNIDEEALARLAQ---EGSEVNVIGIGTSVVTCP--.....---- 133 E-.....--AGYSDCKIVISNSLDEHIITDVLL---QGAEVDSFGVGERLITAK--.....---- 134 A-.....--SGLEDCKIVVSNSLDEYIIEDLIA---QGAKIDVFGVGERMITAK--.....---- 135 E-.....--AGFPGVKIVASNELDEYVIESMRS---EGGRVDIYGVGTRLATCA--.....---- 136 TVgaef.QMPWLEFVPIAVSNNIDEKELARLAQ---KGSEVNVIGIGTNVVTCP--.....---- 137 E-.....--NGLKNVRIIVSGGVDEYKIKEWFD---RGAPIDAFGVGTKFITSA--.....---- 138 S-.....IGVDPKSKVVIYSDGLDVDRCLELAAYSNHIGIGAAFGIGTSFTNDFIQ.....LSTA 139 S-.....RGEDPRRKLVIFSDGLDVEKIEELHRQF-HGQVKVSFGWGTMFTNDFRG.....LVKD 140 Q-.....--AGLQKCKIIVSNALDEWSIKKLKE---QNAPIDIFGVGERLITAS--.....---- 141 TLd12cgKDGSIADCLVIASNDLDEEILYNLVK---EGACIDMFGIGTHLVTCN--.....---- 142 A-.....--AGLPEARIAVSNELDETIIESLVL---SGAPIDAWGVGTHLVTGG--.....---- 143 D-.....--AGFSEAKITASNALDETTIQSL--LFSQGAPIDNFGVGEELITSA--.....---- 144 Q-.....LGIDPTTKLFIFSDGLDFDQALELCEYF-AGRVKISFGIGTFLTNDLAN.....WRNA 145 R-.....--NGLNHVKIIASNELDENIIMYLNS---INAPIDIWGVGTNLVTAK--.....---- 146 E-.....--AGCTKAKISVSNELTEEIVESLVQ---NNAPIDSWGVGTHMVTGG--.....---- 147 E-.....--NGLFEVKIIISNELDEDIIMYLNS---IHAPIDCWGVGTNLVTAK--.....---- 148 LIadkf.GLPWIKQLIIVASNDINEDTLRSLKE-----------------------.....---- 149 A-.....--AGFPNAKITISNALDEHIITSLLH---EGAPIDNFGIGEKLITSA--.....---- 150 K-.....-------VRIFASGDIDEWEIARLQK---ENACIDGYGIGTKLVTGV--.....---- 151 E-.....LRVDPKIKYIIFSDSLTPQRAIEIQKLC-AGRIKASFGIGTNLTNDV--.....---- 152 E-.....LGIDATTKTIVFSNALDFTKALEIQEYC-KDKIRCSFGIGTNLTNDT--.....---- 153 DIssk..LNVPFDGLKICISNDINEKVIETFNQ---DKHHIDMFAIGTNLITCQ--.....---- 154 D-.....-------VSIFASGDLDEWEIAKLQA---AGAEIDGYGLGTKLVTGS--.....---- 155 DIsqk..LNVPFNQLKICVSNDINQKIINYLNE---EQNHIDIFAIGTNLITCQ--.....---- 156 G-.....-------VPIFASGDLDEWEIARLKA---AGAEIDGYGLGTRLVTGS--.....---- 157 D-.....--AGLSYVKIAASNQLDEYVIKSLLE---QKAPIDIFGVGTKLAIGA--.....---- 158 R-.....--GGLGDATVFASGNLDEYEVRRLLA---EGAPIDGFGVGTRLDTSS--.....---- 159 K-.....LGIDPMKKVLVFSDSLHVSDAVKLKEYC-SGRINCSFGIGTTLTNNPDF.....FS-- 160 K-.....-------VNIFASGDIDEWELQRLRS---ENALFDGYGVGTRLVTGH--.....---- 161 T-.....--AGLEQVEIFASSGLDENRIAALLA---ARCPIDGFGVGTQLVVAQ--.....---- 162 A-.....--LGATNTTITVTNDLDEYALAAL-----QTAPVDSYGVGTMLVTGS--.....---- 163 E-.....--EGFTKAKITLTNSLDEQLIRSLRE---QGACVDMYGVGDAIAVSK--.....---- 164 A-.....--LGATNTTITVTNDLDEYALAAL-----QTAPVDSYGVGTMLVTGS--.....---- 165 Q-.....-------AKIIASGDLDEGEIRRLQA---AGAAIDAYGIGTKLVTGE--.....---- 166 RCs15sfSAPAFDSLIIVGTNNISEKSLTEINL---RENEIDVVGVGTHLVTCTRQp18vfCSGG 167 D-.....--LNAHNTKIVVSSDLDEFAIAGL-----RGEPVDVFGVGTSVVTGS--.....---- 168 D-.....--LGAHNTKIVVSSDLDEFTIAGL-----RGEPVDVFGVGTSVVTGS--.....---- 169 R-.....LGIDPTEKTLVFSDGLNLDKAVELFR-----------------------.....---- 170 E-.....--EGFTKAKITLTNSLDEQLIRSLRE---QGACVDMYGVGDAIAVSK--.....---- 171 N-.....--LGAHNTQIVVSSDLDEYAIAGL-----RGNPVDVFGVGTSVVTGS--.....---- 172 K-.....LGIDPMTKTLVFSDGLNLTKTLEIFRAL-RGRINVSFGIGTNLTCDI--.....---- 173 --.....-------------------------------------------------.....---- 174 A-.....NRVDPLGKTLIFSDSLDIPRVIELYERF-HGRCKLAFGVGTNLTNDL--.....---- 175 ACgahf.QVPWFGSIPIAVSNDISERSVEDFVR---EGSEIDMVGVGTNLVTCP--.....---- 176 K-.....LRIDSRTKMLTFSDGLDLEKSWALHQYL-KDRFKTSFGIGTNLTNDL--.....---- 177 I-.....--RGHKNIKIMVSGGIKLEDIPEL-----ISAGVESFGIGTSISSAK--.....---- 178 RIseqf.KLPWFSKLTIVASNDINEETILSLNE---QGHKIDCFGIGTHLVTCQ--.....---- 179 I-.....--RGYNNIKIMASGGLKLEDLKDL-----VDAGVSAFGIGTSIA-----.....---- 180 AAaaqf.QVPWLESVLIVVSNNIDEEALARLAQ---EGSEVNVIGIGTSVVTCP--.....---- 181 RCsehf.SVPAFDSLIIVGTNNISEKSLTELSL---KENQIDVVGVGTHLVTCT--.....---- 182 --.....-------------------------------------------------.....---- 370 380 390 400 410 420 | | | | | | 1 Q.VKSEPLNIVIKLLEVNGN.....HAIKISDNLGK.....NMGDPATVKRVKEELGYTERSWSG 2 -.-GYNPLQIVIKMVRCNGQ.....PVAKLSDSPGK.....NMCEDKAYLAYLRQVFGI------ 3 -.-GYKPLQIVIKMVRCNGQ.....PVAKLSDTPEK.....TMCDDPGYLSYLRQVF-------- 4 -.-GYVPLQIVIKMVRCNGQ.....PVAKLSDSPGK.....SMCDDKAYLAYLRQVFGIA----- 5 -.-GYVPLQIVIKMVRCNGQ.....PVAKLSDSPGK.....SMCDDKAYLAYLRQVFGIAQP--- 6 -.-GYTPLQIVIKMVRCNGQ.....PVAKLSDAPEK.....TMCDDPAYLAYLKQVFG------- 7 Q.VKSEPLNIVIKLLEVNGN.....HAIKISDNLGK.....NMGDPATVKRVKEELGYTERSWSG 8 -.-GYTPLQIVIKMVRCNGQ.....PVAKLSDAPEK.....TMCDDPAYLAYLKQVFG------- 9 -.PQVKPLNIVIKLVECNGK.....PVAKLSDSPGK.....TICHDKAFVRALRKAFDL------ 10 -.PQVKPLNIVIKLVECNGK.....PVAKLSDSPGK.....TICHDKAFVRALRKAFDL------ 11 -.PQVKPLNIVIKLVECNGK.....PVAKLSDSPGK.....TICHDKAFVRALRKAFDL------ 12 -.PQVKPLNIVIKLVECNGK.....PVAKLSDSPGK.....TICHDKAFVRALRKAFDL------ 13 -.PQVKPLNIVIKLVECNGK.....PVAKLSDSPGK.....TICHDKAFVRALRKAFDL------ 14 -.-GHEPLQIVMKMVRCNGQ.....PVAKVSDAPEK.....TMCDDPAYLAYLRQVFQ------- 15 -.PGVEPMNIVLKMTACNGH.....PVAKISDAPGK.....TQCRDENFVAYLRHVFN------- 16 -.-GHEPLQIVMKMVRCNGQ.....PVAKVSDAPEK.....TMCDDPAYLAYLRQVFQ------- 17 -.PGVEPMNIVLKMTACNGH.....PVAKISDAPGK.....TQCRDENFVAYLRHVFN------- 18 -.-GHEPLQIVMKMVRCNGQ.....PVAKVSDAPEK.....TMCDDPAYLAYLRQVFQ------- 19 -.-GPTPLQIVIKMVRCNGQ.....PVAKLSDSPGK.....SMCEDIGYLRYLRDVFGLP----- 20 -.-GPTPLQIVIKMVRCNGQ.....PVAKLSDSPGK.....SMCDDPGYLHYLRQVFGV------ 21 -.-GPTPLQIVIKMVRCNGQ.....PVAKLSDSPGK.....SMCDDPGYLHYLRQVFGV------ 22 -.-GPTPLQIVIKMVRCNGQ.....PVAKLSDSPGK.....SMCDDPAYLHYLRQVFGV------ 23 -.PGIAPMNMVLKMTACAGQ.....AVAKISDESGK.....TQCKDPNFVAYLRHVFKVP----- 24 -.-GPTPLQIVIKMVRCNGQ.....PVAKLSDSPGK.....SMCEDLGYLRYLRDVFGLPPM--- 25 -.-GLEPLQIVLKLVSCNGQ.....PVAKLSDSPGK.....TMCSDETFLAYLRQVFKV------ 26 -.PQVKPLNIVIKLVECNGK.....PVAKLSDSPGK.....TICHDKAFVRALRKAFDL------ 27 -.PQVKPLNIVIKLVECNGK.....PVAKLSDSPGK.....TICHDKAFVRALRKAFDL------ 28 -.PGIAPMNMVLKMTACAGQ.....AVAKISDEPGK.....TQCKDPNFVAYLRHVFKVP----- 29 -.PGVKPLNIVIKLVECNGK.....PVAKLSDSPGK.....TICEDNEFVNRLRAAFDI------ 30 -.PGVEPMSIVLKMTACNGQ.....PVAKISDEPGK.....THCKDPNFVAYLRHVFQVP----- 31 -.-AQAALGCVFKLVEINNQ.....PRIKLSEDVTK.....VSIPCKKRTYRLFGKEGYPLVD-- 32 -.-GHTPLNIVLKLVECNGQ.....SVAKLSDSPGK.....TMTNNSTFLAYLRQVFDVP----- 33 -.-GHTPLNIVLKLVECNGQ.....SVAKLSDSPGK.....TMTNNSTFLAYLRQVFDVP----- 34 -.-GITPLNIVLKLVECNGQ.....PVAKLSDSPGK.....TMINNDTYLAYLRQVFDV------ 35 -.-GHTPLNIVLKLVECNGQ.....SVAKLSDSPGK.....TMTNNSTFLAYLRQVFDVP----- 36 -.PGVEPMNIVVKMSACNGH.....PVAKISDTPGK.....AQCRDPDFIHYLKHV--------- 37 -.-RQPALGCVYKMVEINNQ.....PRIKLSQDVGK.....VTMPGSKNVFRLYGADG------- 38 -.-RQPALGCVYKLVEINGQ.....PRIKLSQDVEK.....VTMPGNKNAYRLYSADG------- 39 -.-SQAALGCVFKLVEINNQ.....PRIKLSEDVTK.....VSIPCKKRSYRLYGKEGYPLVD-- 40 -.PDVKPLNIVIKLVECNDK.....PVAKLSDSPGK.....TICQDPAFVDQLRKAFA------- 41 -.PDVKPLNIVIKLVECNDK.....PVAKLSDSPGK.....TICQDPAFVDQLRKAFA------- 42 -.-AQAALGCVFKLVEINKQ.....PRIKLSEDVTK.....VSIPCKKRCYRLFGKEGYPLVD-- 43 D.AKSEPLNIVFKLLTVNGR.....PAIKISDDLGK.....TMGDPEKVEEVKRELGYIERTWEG 44 K.-KSVPLNIVIKISSAAGR.....PAVKISDNIGK.....NTGDKETVEKVKQELGYVEREWKE 45 -.-SQAALGCVFKLVEINNQ.....PRIKLSEDVTK.....VSIPCKKRSYRLYGKEGYPLVD-- 46 -.-KQPALGCVYKLVAQSSQ.....PKIKLSQDVTK.....ITIPGKKKCYRIFGKNGYA----- 47 K.-KSVPLNIVIKISSAAGN.....PAVKISDNAGK.....NTGDKETVEKVKRELGYVEREWKE 48 K.-KSTPLNIVIKLSSAAGN.....PAVKISDNVGK.....NTGDKATVEKVKRELGYVEKDWSE 49 -.-AQAALGVVFKLVDINNQ.....PRIKLSEDVSK.....VSIPCKKRSYRLYGKEGYPLVDIM 50 -.PGVAPMNIVLKMTDCNGA.....PVAKISDEAAK.....TQCRDENFVAYMRHVFKV------ 51 -.-KQPALGCVYKLVAQSAQ.....PKIKLSQDVTK.....ITIPGKKKCYRIFGKNGY------ 52 -.-KQPALGCVYKLVAQSAQ.....PKIKLSQDVTK.....ITIPGKKKCYRIFGKNGY------ 53 -.-KQPALGCVYKLVAQSAQ.....PKIKLSQDVTK.....ITIPGKKKCYRIFGKNGY------ 54 -.-KQPALGCVYKLVAQSAQ.....PKIKLSQDVTK.....ITIPGKKKCYRIFGKNGY------ 55 -.PYVKPLNIVIKLVECNGK.....PVAKISDSPGK.....TFCLDRIFLKNLCQVFNV------ 56 E.-KSQPMNIVIKIKEANGK.....PAIKISDNIGK.....NMGDQATVDRVKQELGYTERTWSE 57 -.-DQPALGAVYKMVSIERDgkmv.DTIKLSNNAEK.....VSTPGKKQVWRISR---------- 58 -.-DQPALGAVYKLVAIENEegsysDRIKLSNNAEK.....VTTPGKKNVYRIINK--------- 59 -.-DQPALGAVYKLVAIENEdgsysDRIKLSNNAEK.....VTTPGKKNVYRIINK--------- 60 -.-SQAALGCVFKLVEINSR.....PRIKLSEDVAKch6fqVSIPCKKRCFRLYGKEGYPL---- 61 -.-DQPALGAVYKMVSIENDhhqmvDTIKLSNNAEK.....VSTPGQKQVWRITK---------- 62 -.-DQPALGAVYKLVAIENEdgsysDRIKLSNNAEK.....VTTPGKKNVYRIINK--------- 63 -.-DQPALGAVYKMVSIDGD.....DTIKLSNNVEK.....ISTPGKKQVWRITDSK-------- 64 -.-DQPALGAVFKLVSIEGEdgqmkDTIKLSSNAEK.....VTTPGKKQVWRITRKS-------- 65 -.-AQPALGCVYKLVEINGS.....PRIKLSQEANK.....ITLPGRKTAYRLFGSEGHPL---- 66 -.-RQPALGCVYKMVEINNQ.....PRIKLSQDVGK.....VTMPGSKNVFRLYGADG------- 67 -.-RQPALGCVYKMVEINNQ.....PRIKLSQDVGK.....VTMPGSKNVFRLYGADG------- 68 -.-DQPALGAVYKLVAIENEdgsysDRIKLSNNAEK.....VTTPGKKNVYRIINK--------- 69 -.-SQAALGCVFKLVEINSR.....PRIKLSEDVAKch6fqVSIPCKKRCFRLYGKEGYPL---- 70 E.-KSQPLNIVIKISSANGR.....AAVKLSDNMGK.....NTGDKDTVQAVKKRLGYVEHEWEE 71 -.-DQPALGAVFKLVSIEDDegkmmDTIKLSSNAEK.....VTTPGKKQVWRITRNFD------- 72 -.PNVKPLNIVIKLVKCNGK.....PVAKLSDSPGK.....TFCLDRNFIKSLCKAF-------- 73 QgEAYQPLSIVIKMVTCNGS.....PVAKISDEPEK.....AMCEDIFFLMNLKRRFEQPLDL-- 74 -.-DQPALGGVYKLVAIEDKdgnmrDTLKISSNAEK.....VSTPGKKQVWRIQ----------- 75 -.-DTPALGGVYKLSAEGQKgvfe.PRLKVSENISK.....ITNPGIKKIVRFYDRRGK------ 76 -.-DQPALGAVYKIVAIEDEtgqmrNTIKLSNNAEK.....VSTPGKKQVWRITS---------- 77 -.-DQPALGGVYKLVAIEDKegkmrDTLKISSNAEK.....VSTPGKKQVWRIQ----------- 78 SiDGLKAISLVCKVTDANGH.....PAVKLSDNPQK.....ATGDPKEVARYLRFFGN------- 79 -.PGVETLNVVLKLTQCEGR.....PVAKISDEPGK.....IMCRDEDYLTQLRQA--------- 80 -.-RQPALGCVYKLVEINGQ.....PRIKLSQDVEK.....VTMPGNKNAYRLYSADG------- 81 -.-DQPALGAVYKIVSIETDagsmrDTIKLSNNAEK.....VSTPGKKQVWRIT----------- 82 -.-DQPALGAVYKLVSMEDEsgqmqDTIKLSSNAEK.....VSTPGKKQVWRITKK--------- 83 -.-QQPSLGGVYKLVAVGGQ.....PRMKLTEDPEK.....QTLPGSKAAFRLLGSDGSP----- 84 -.-QQPSLGGVYKLVAVGGQ.....PRMKLTEDPEK.....QTLPGSKAAFRLLGSDGSP----- 85 -.-DQPALGAVYKLVSIETDdgtmsDRIKLSNNAEK.....VTTPGKKNVYRIIN---------- 86 -.-QQPSLGGVYKLVAVGGQ.....PRMKLTEDPEK.....QTLPGSKAAFRLLGSDGSP----- 87 SiDGLKAISLVCKVTDANGH.....PAVKLSDNPQK.....ATGDPKEVARYLRFFGN------- 88 -.-DQPALGAVYKIVSIEQEdgsmrDTIKLSNNAEK.....VSTPGKKQVWRITS---------- 89 -.-DQPALGAVYKIVSIEQEdgsmrDTIKLSNNAEK.....VSTPGKKQVWRITS---------- 90 -.-DQPALGAVYKIVSIEQEdgsmrDTIKLSNNAEK.....VSTPGKKQVWRITS---------- 91 K.-KSTPLNIVIKLSSADGK.....PAVKLSDNIGK.....NTGDANTVEKVKREIGYEEKDWEG 92 TiASLKPISIVCKVSDANGR.....PAVKLSDNPQK.....ATGDPAEVERYLKFFGE------- 93 TiASLKPISIVCKVSDANGR.....PAVKLSDNPQK.....ATGDPAEVERYLKFFGE------- 94 EtATFDALSLVCKVTHANGR.....PAVKLSDNPEK.....TIGNPQEIQRYLNFFG-------- 95 -.-EQPALGAVYKLVAIEDTdgklnDTIKISSNPEK.....ITTPGLKRIYRIIN---------- 96 EtNSLDAISLVCKVTEANGR.....PAVKLSDNPAK.....ATGDEKEIERYLRIFG-------- 97 -.-EQPALGAVYKLVAIEDTdgklnDTIKISSNPEK.....ITTPGLKRIYRIIN---------- 98 -.-EQPALGAVYKLVAIEDTdgklnDTIKISSNPEK.....ITTPGLKRIYRIIN---------- 99 EiNGLNPISIVCKVSEANGR.....PAVKLSDNPRK.....ATGDPAEVERYLKFFG-------- 100 -.-EQPALGAVYKLVAIEDTdgklnDTIKISSNPEK.....ITTPGLKRIYRIIN---------- 101 KiATFDALSLVCKVTHANGR.....PAVKLSDNPEK.....TIGDPREIQRYLNFFG-------- 102 -.-DQPALGAVYKIVSIEDDngvmqDTIKLSNNAEK.....VSTPGKKQVWRIT----------- 103 -.-AQAALGCVFKLVEINKQ.....PRIKLSED---.....VSIPCKKRCYRLFGKEGYPLVD-- 104 -.-EQPALGAVYKLVAIEDTdgklnDTIKISSNPEK.....ITTPGLKRIYRIIN---------- 105 -.-KQPSMGCVYKLVSVGGQ.....PRIKLTEDPEK.....QTLPGSKAAFRFLGPD-------- 106 Q.VKSEPLNIVIKLLEVNGN.....HAIKISDNLGK.....NMGDPATVKRVKEELGYTERSWSG 107 KiDRLKAISLVCKVSSANGR.....PAVKLSDNPEK.....ATGRPEEIQRYLRVFG-------- 108 -.-TEPVFGGVYKLVAVEENgtii.PKIKMSENVVK.....ITNPGYKKVFRLFD---------- 109 KgTRYQPISMVVKMAECNGS.....PVAKISDEPEK.....AMCEDIFFLMNLKQRFGLEVDLDK 110 KgIRYQPISMVVKMAECNGS.....PVAKISDEPEK.....AMCEDIFFLMNLKQRFGLEVDLDK 111 S.EVSKPMNIVIKLFSAEGT.....KAVKISDDIMK.....NTGDRDAVI--------------- 112 -.-AQAALGCVFKLVEINNQ.....PRIKLSEDVTK.....VSIPCKKRTYRLFGKEGYPLVD-- 113 -.-KQPSMGCVYKLVSVGGQ.....PRIKLTEDPEK.....QTLPGSKAAFRFLGPD-------- 114 -.-RQPSLGCVYKLVSVGGQ.....PRMKLTEDPEK.....QTLPGSKAAFRLLGSD-------- 115 -.-ESPPLNMVIKLHSVNGI.....PVVKLSDSPEK.....ETGERDALRVANYIVG-------- 116 -.-KSPPLNMVIKLHSIDGI.....PVVKLSDSPEK.....ETGEKDAIRVANYIFG-------- 117 -.-SEPVFGGVYKLVAVEEDykii.PKIKISENEEK.....ITNPGFKKVYRIFD---------- 118 GsFNLDPISLVCKVSSVDGH.....PAVKLSDNPEK.....ATGLPSEIERYLRVFGDV------ 119 -.-DQPALGAVYKLVSIEDEngdmkDTIKLSGNPEK.....MTTPAMKKVYRIINKEN------- 120 -.-KQPSMGCVYKLVSVGGQ.....PRIKLTEESQK.....ETLPGSKAAFRFL----------- 121 -.-ESPPLNMVIKLHSINGI.....PVVKLSDSPEK.....ETGERDALRVANYIVG-------- 122 -.-RQPSLGCVYKLVEVRGR.....PRMKLSEDPEK.....STLPGRKAVYRLLDADGHP----- 123 -.-SEPVFGGVYKLVAVEDEegniiPRIKISENEEK.....ITNPGFKRIIRIFD---------- 124 -.-DQPALGAVYKLVAIEEDgkmv.DTIKISSNPEK.....VTTPGRKKVYRIINQ--------- 125 G.PGGGALGGVYKLAELNGR.....PRMKLTGDPAK.....SSLPGTKAVWRGLDHDHFAWDVL- 126 G.EGGGALGGVYKLVRIGDR.....PRLKVTSDLAK.....ATLPDRKRLLRAVAADG------- 127 -.-DQPALGAVYKMAAIADEndilqDSIKLSSNTEK.....VSTPGKKKVYRII----------- 128 -.-DQPALGAVYKMAAIADEndilqDSIKLSSNTEK.....VSTPGKKKVYRII----------- 129 -.-DQPALGAVYKMAAIADEndilqDSIKLSSNTEK.....VSTPGKKKVYRII----------- 130 -.-DQPALGAVYKMAAIADEndilqDSIKLSSNTEK.....VSTPGKKKVYRII----------- 131 -.-QQPSLGGVYKLVAVGGQ.....PRMKLTEDPEK.....QTLPGSKAAFRLLGSDGSP----- 132 -.-QQPSLGGVYKLVAVGGQ.....PRMKLTEDPEK.....QTLPGSKAAFRLLGSDGSP----- 133 -.-SEPVFGGVFKLCAVENDegnivPKIKISENQEK.....ITNPGFKKIYRLFD---------- 134 -.-SDPVFGGVYKLVAVEEDgqiv.PRIKLSENAEK.....ITNPGYKTPWRLYD---------- 135 G.EGGGALGGVYKLVRIGDR.....PKLKVTSDVAK.....ATLPDRKRLLRAV----------- 136 -.-KQPSMGCVYKLVSVGGQ.....PRIKLTEESQK.....RILPGSKAAFRFLDS--------- 137 -.-DAPYFDIAYKLVEYEGK.....PKYKLSP--GK.....KTFPYKRQVYRYYENGKMKYDETA 138 Q.-KSKPLNIVIKLDSVEHR.....RVVKISDDLTK.....NTGDPTEVLAVKRRFG-------- 139 D.-ALAPFSLVCKAVAADGR.....PTVKLSDNPLK.....AMGPADEIARYKRVFG-------- 140 -.-SDPIFSCVYKLAALEDQgik..PKIKISENNEK.....STLPHFKKLFRVYDKN-------- 141 -.-SQPSLGGVYKLVELDGI.....PRIKFSDEIGK.....VTIPGQKILYRLYTSTHT------ 142 -.-ADSAFTGVYKMSARATTq24wlPVMKVSDNPAK.....TTTPGIKQVWRLYDAA-------- 143 -.-SDPVLSGVYKLVAIKKEgkii.PKIKISDSREK.....VTLPGIKQLYRLYKKG-------- 144 AgVEYRPLSIVIKLAECQGR.....PVAKISDQPEK.....AMCEDPIFLANLKRRFNIELDVDA 145 -.-GDPSLSGVYKMISIEKNgkfi.PKIKISNNAEK.....STLPDQKEVARIYLNDQMILDFIF 146 -.-NEASLTGVYKMAARKSLge6wtPVMKFSDNPAK.....MTNPACKQVWRLYNPDGTF----- 147 -.-GEPNLSGVYKMISIQQNgkfi.PKMKISNNVDK.....ATLPSQKGVVRIYSNAQMIFDLIF 148 -.----------QLVEVNGE.....PRMKLSEDVEK.....INLPGKKNVFRLYSEDG------- 149 -.-SAPVLSGVYKLAATESNgqst.PKIKVSASREK.....LTIPGDKQVYRLYEP--------- 150 -.----PVNGVYKLVEIDGI.....PAMKNTT--GK.....VSYPGRKQIYRYLENGQLKQDYL- 151 G.GGVEPLNIVMKLWKCKMTak6whYCVKLSDVDGK.....HTGEPEEILLA------------- 152 -.-GFAPSNIVMKLTQCKMNvn6wrECIKLSDDEGK.....HTGSPEEVQACLY----------- 153 -.-SQPSLGLVFKLVEINNQ.....PCFKITNEHIK.....SNYPYKKMLYRLYT---------- 154 -.----PVNGVYKLVEIDDI.....PVMKKSS--GK.....TTYPGRKQIFRSFGDGQVQADR-- 155 -.-SQPSLGLVYKLVQINNA.....PCFKMTNENKK.....SNLPYQKNVYRIY----------- 156 -.----PVNGVYKLVDIDGI.....PVMKQSS--GK.....VTYPGRKQIFRSYTGGKVKADRLG 157 -.-PDAALDGVYKLAMSNLK.....PRIKLSESIAK.....ITLPYKKQVYRVIDQ--------- 158 -.-DAPYLDCVYKLQEYAGQ.....PRRKRSE--GK.....ATWPGRKQVWRRYDDDGRC----- 159 -.-YNPPLNMVIKLHKIDGI.....PVVKLSDSVEK.....ATGDKDALRVANYIFGR------- 160 -.----PVNGVYKLVEIDNV.....PTMKQSS--NK.....MTYPGRKQIFRRYNNGIIESDRLA 161 -.-DAPALDMAYKLVAYDGS.....GRTKFSS--GK.....VIYPGRKQVFRKLEHGVFCGDTLG 162 -.-GAPTCAMVYKLTEREGAdgtmvPVMKKSK--DK.....ATVPGRKLAFRSYEYALAEAEHVI 163 -.-SYPCFGGVYKIVELDEV.....PLIKISGDVIK.....ISNPGFKEVYRIFDKDGF------ 164 -.-GAPTCAMVYKLTEREGAdgtmvPVMKKSK--DK.....ATVPGRKLAFRSYEYALAEAEHVI 165 -.----PVNGVYKLVEINGQ.....GVMKIAS--GK.....MTLPGRKQIYRRP----------- 166 C.PSCPSGACVVQLVEVRGR.....PRMKISEDPEK.....STLPGRKQVFRLMDADGG------ 167 -.-GAPTAGLVYKIVEVAGH.....PVAKRSRNKES.....Y-GGGKK----------------- 168 -.-GAPTAGLVYKLVEVDGH.....PVAKRSR--NK.....ASHGGAKKAVR------------- 169 -.------------------.....-----------.....------------------------ 170 -.-SYPCFGGVYKIVELDEE.....PLIKISGDVIK.....ISNPGFKEVYRIFDKEGF------ 171 -.-GAPTAGMVYKLVEVDGN.....PVSKRSR--GK.....GMLGGAKRAARTHRASG------- 172 -.PGVAPMSIVLKMTDCNGQ.....PVAKISDEAAK.....TQCRDANFVAYLRHVFKV------ 173 -.------------------.....-----------.....------------------------ 174 -.-GYTPLQIVIKMVRCNGQ.....PVAKLSDTPEK.....TMCDDPGYLAYLRQVFD------- 175 -.-LQPSLGCVYKLVEVNGS.....PCLKFTEEEEK.....MTIPGIKAIYRLYDAAGHPF---- 176 -.-GHVTLNIVLKLVLCNGQ.....SVAKISDTPGK.....TMTDNDTFLAYLRQVFGL------ 177 -.----PVDFGMDIVNIDGT.....DITKRG-----.....-KFSGIKSVYRCKNCN-------- 178 -.-RQPALGCVYKMVEINAQ.....PRIKLSQDVVK.....VTMPGNKNVFRLYGADG------- 179 -.-SAEPVDFSLDIVNVEGT.....NITKR------.....------------------------ 180 -.-QQPSLGGVYKLVAVGGQ.....PRMKLTEDPEK.....QTLPGSKAAFRLLGSDGSP----- 181 -.-TQPSLGCVYKLVEVRGR.....PRMKISEDPEK.....STVPGRKQVYRLMDTD-------- 182 -.------------------.....-----------.....------------------------ 430 | 1 DNEAHRWTZ 2 --------- 3 --------- 4 --------- 5 --------- 6 --------- 7 DNEAHR--- 8 --------- 9 --------- 10 --------- 11 --------- 12 --------- 13 --------- 14 --------- 15 --------- 16 --------- 17 --------- 18 --------- 19 --------- 20 --------- 21 --------- 22 --------- 23 --------- 24 --------- 25 --------- 26 --------- 27 --------- 28 --------- 29 --------- 30 --------- 31 --------- 32 --------- 33 --------- 34 --------- 35 --------- 36 --------- 37 --------- 38 --------- 39 --------- 40 --------- 41 --------- 42 --------- 43 SDEAHRWK- 44 GDETSRWG- 45 --------- 46 --------- 47 GDETSRWG- 48 GDESARWG- 49 --------- 50 --------- 51 --------- 52 --------- 53 --------- 54 --------- 55 --------- 56 GDETHRWS- 57 --------- 58 --------- 59 --------- 60 --------- 61 --------- 62 --------- 63 --------- 64 --------- 65 --------- 66 --------- 67 --------- 68 --------- 69 --------- 70 GDERNRW-- 71 --------- 72 --------- 73 --------- 74 --------- 75 --------- 76 --------- 77 --------- 78 --------- 79 --------- 80 --------- 81 --------- 82 --------- 83 --------- 84 --------- 85 --------- 86 --------- 87 --------- 88 --------- 89 --------- 90 --------- 91 GDETSRL-- 92 --------- 93 --------- 94 --------- 95 --------- 96 --------- 97 --------- 98 --------- 99 --------- 100 --------- 101 --------- 102 --------- 103 --------- 104 --------- 105 --------- 106 DNEAHR--- 107 --------- 108 --------- 109 AIET----- 110 AIET----- 111 --------- 112 --------- 113 --------- 114 --------- 115 --------- 116 --------- 117 --------- 118 --------- 119 --------- 120 --------- 121 --------- 122 --------- 123 --------- 124 --------- 125 --------- 126 --------- 127 --------- 128 --------- 129 --------- 130 --------- 131 --------- 132 --------- 133 --------- 134 --------- 135 --------- 136 --------- 137 KWESKR--- 138 --------- 139 --------- 140 --------- 141 --------- 142 --------- 143 --------- 144 LIQELR--- 145 LKEE----- 146 --------- 147 LKEE----- 148 --------- 149 --------- 150 --------- 151 --------- 152 --------- 153 --------- 154 --------- 155 --------- 156 --------- 157 --------- 158 --------- 159 --------- 160 LIE------ 161 EHGE----- 162 SGSE----- 163 --------- 164 SGSE----- 165 --------- 166 --------- 167 --------- 168 --------- 169 --------- 170 --------- 171 --------- 172 --------- 173 --------- 174 --------- 175 --------- 176 --------- 177 --------- 178 --------- 179 --------- 180 --------- 181 --------- 182 ---------