(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html

Citations (SAM, SAM-T99, HMMs)

Sequence numbers correspond to the following labels:

    • T0217 TM1631, Thermotoga maritima
    • gi|45530416|ref|ZP_00181547.1|_28:281 COG1801: Uncharacterized conserved protein [Moorella thermoacetica ATCC 39073]
              10             20            30        40        50      
              |              |             |         |         |      
   1 MVYVGTSGFSFEDWK.....GVVYPEHLK....PSQFLKYYWAVLGFRIVELNFTYYTQPSWRSF
   2 MVYVGTSGFSFEDWK.....GVVYPEHLK....PSQFLKYYWAVLGFRIVELNFTYYTQPSWRSF
   3 MLFIGVTGWGDHD--.....-SLYIDPYE....NRNKLRTYSEY--FPIVEVDSSFYAMQPERNY
   4 MLFIGVTGWGDHD--.....-SLYIDPYE....NRNKLRTYSEY--FPIVEVDSSFYAMQPARNY
   5 -LFIGVTGWGDHD--.....-SLYIDPYE....NRNKLRTYSEH--FPIVEVDSSFYAMQPARNY
   6 MITIGLTGWSDHDSLlq...--------T....KKLTLADYAAH--FPVVEVDTSFYAIPSPRTT
   7 -LYIGTSGWAYSHWK.....EIFYPSNLP....YEERLSFYSKH--FLSAEVNSSFYHLPQEKTL
   8 MIYIGLTGWGDHD--.....-ELYTMGTK....PSEKLYTYGSH--FPAVEVDSSFYAIQPKRNM
   9 MVTIGLTGWSDHDSLlq...--------T....KKLTLADYAAH--FPVVEVDTSFYAIPSPRTT
  10 MIYVGVTGWGDHD--.....-SLYPTPQD....RKEKLAAYAGH--FPAVEVDSTYYAIQPERNY
  11 -------GWGDHD--.....-SLYINPYE....NRNKLRTYSEY--FPIVEVDSSFYAMQPARNY
  12 -IYIGLTGWGDHD--.....-SIYPPKTA....SQKKLQAYSSH--FPIVELDASFYAIQPARNN
  13 MITIGLTGWSDHDSLlq...--------T....KKLTLADYAAH--FPVVEVDTSFYAIPSPRTT
  14 NIRIGCSGWYYPHWA.....GKFYPSDLN....KSEWFRYYAQK--FDTVEINSTFYSFPNAARV
  15 MVTIGLTGWSDHDSLl....-------QS....KKLTLADYAAH--FPVVEVDTSFYAIPSPRTT
  16 -YYLGCSGYFYPGWR.....GKFYPKDLK....PKDWLKYYSKF--FNTVEINSTFYHFPNEKNL
  17 MVTIGLTGWSDHDSLl....-------QS....KKLTLADYAAH--FPVVEVDTSFYAIPSPRTT
  18 MIYIGLTGWGDHD--.....-TLYTADSK....PQEKLQDYSSH--FPIVELDASFYAIQPHRNI
  19 MIEIGLTGWGDHD--.....-TLYEDLER....KTDKLKTYASH--FPIVELDASYYAIQPERNI
  20 -IYIGTSGYSYRDWQ.....GYFYPRGLA....AKDMLPYYARE--FNFTEINSSYYALPRPQNL
  21 -IRIGISGWRYARWR.....GTFYPTGLA....QRRELAYAGRC--FPSVEINGSFYSLQRPESY
  22 -VHIGTSGWHYDHWR.....GTFYPPGLP....ADRLLEHYATR--FETAEINNSFYRLPEAKTL
  23 -ICIGISGWRYARWR.....GTFYPAGLA....QRRELEYAAGC--FPSVEINGSFYSLQRPESF
  24 -IRVGISGWTYKPWR.....GVFYPAGLP....HKQELSYAAQH--FRSVEINGTFYSMQWPESF
  25 -IRIGISGWRYGPWR.....KDFYPKGLK....QDDELAFASRA--VNSIEINGSFYSLQTPERY
  26 -LRIGISGWRYAPWR.....GDFYPEGLR....QKDELRFASRA--VNSIEINGTFYALQTPERF
  27 -IHIGISGWRYAPWR.....GDFYPKGLA....QKRELQFASRA--VNSIEINGSFYALQRPERY
  28 MINIGLTGWGDHY--.....-SLYEDLER....QTDKLKTYAGH--FPVVELDATYYAIQPERNI
  29 -YRVGTSGWVYPPWR.....NTFYPQDLP....QKKELFFASRH--LSSIEINGSFYSYQKPSTY
  30 -LRLGLTMWSHNQWQ.....QSFYGSGTK....PAERLEKYAQV--FHTVEGNTTFYATPTHNTV
  31 -YYLGCPSWSENAWR.....DSLYPEDAR....PTDFLSLYTQV--FNVVEGNTTFYARPAATTV
  32 --KIGTSGWVYKHWM.....DIFYPPNLP....SDQQLSFYAQH--FATVEINFSFYRLPERSVF
  33 -VRIGTSGWSYDHWA.....DVLYPPGTP....SARRLARYIEV--FDTVELNASFYRWPKDSTF
  34 -LYLGTSGWSYADWE.....GSLYPAGLA....PQGRLAEYARH--YATVEIDSTFYGIPRRSTV
  35 -YFLGCPSWNEAAWR.....GSFYPRELR....SADYLGHYGGI--FNAVEGNTTFYARPSAETV
  36 -FFIGCAVWAYKGWV.....GELYPQGTR....TADFLHLYSRR--FTTVEGNTTFYAVPNQETV
  37 -YYLGCPSWSENAWR.....DSLYPENAR....PNDFLNLYTQV--FNAVEGNTTFYARPAATTV
  38 MIRLGLTSFSEHDYL.....TG------K....KRSTLYEYASH--LPLVEMDTAYYGIPPKERV
  39 -LRLGLTLWSHPAWQ.....SEFYGSGTQ....ASERLAKYASV--FHTVEGNTTFYASPSPSTV
  40 -LFLGLAMWSHNQWQ.....KSLYGSGCK....NSDRLARYAEV--FNTVEGNTTFYATPAITTV
  41 -IRIGIGGWTYEPWR.....GVFYPDKLP....QRRELEYAASK--LTSIEINGTFYGSQKPESF
  42 --SIGCAVWAYKGWV.....GELYPPGTR....AGEFLHLYSRR--FTTVEGNTTFYATPNQETV
  43 -FFIGCSGWFYLHWK.....GRFYPEDIH....TKYWFRYYSSR--FNTVELNSTFYRFPSDKTA
  44 -IRVGIGGWNFEPWE.....GTFYPDDLP....KKRQLEFAGKE--LRTIEVNGTYYSSQKPATF
  45 -IRAGIGGWTFEPWE.....GTFYPDDLP....KKRQLEYASRQ--IPTIEVNGTYYSTFRPDTY
  46 --SIGCAVWAYKGWV.....GELYPQGSR....AGEFLHLYSRR--FTTVEGNTTFYAAPNQETV
  47 -IRVGTSGWSYDHWE.....GVLYPPGTP....ARDRLALYVRE--FPTVELNASFYRWPRDASF
  48 --CLGCPSWSEAGWR.....GRLYPDGTP....ASDYLALYARV--FNAVEGNTTFYARPSAATV
  49 -IRTGIGGWTFEPWE.....GTFYPEKLT....KKRQLEHASRQ--LTAIEVNGTYYSSQKPETF
  50 -IRTGIGGWTFEPWE.....GTFYPEKLT....KKRQLEHASRQ--LTAIEVNGTYYSSQKPETF
  51 -VYIGCGGYTDEDWTa....PGLIYEGVK....KDAFLETYAHH--FDAVELNSSFYAIPGLKAF
  52 -YFLGCPSWSENAWR.....DYLYPADAN....SNQMLGFYSQV--FNAVEGNTTFYARPAPGTI
  53 --HIGCSGYNYREWK.....GMFYPEGLP....QSKWLEYYCRH--YNTVEINASFYRFPTGKSL
  54 -LFVGTSGWQYKDWL.....GALYPPGCP....TRLWLEEYATR--FATVEINNAFYRLPSRGTF
  55 -VRIGISGWRYRAWR.....GDFYPQGLR....QRDELAYAAAR--FDTVEVNGSFYSLQRPTSY
  56 -YYLGCPSWSENAWR.....EYLYPVDAK....TSDLLGLYSQV--FNAVEGNTTFYASPSPATV
  57 NIFIGVGGWTFEPWR.....GVFYPEKLT....QAKELSYAASK--LTSIEINGTYYGSQKPESF
  58 -IRVGTASWTDPTLLa....SGWYPPGVRnh..PERRLRYYAQH--FDTVEVDSTFYALPRLEVV
  59 MIRIGLTSFKEHDKL.....TG------K....KNNTLYEYAGF--LPLVELDTAYYGIPRKSSV
  60 -IYLGTGGYSDTDLL.....GTLYPTGTK....KTDFLREYAKQ--YGAVEINSTFYAPIGQKAF
  61 -IHIGISGWRYAGWR.....GTFYPKGLK....QADELRYAASR--LQTIEINGTHYSLQSLASW
  62 -LRLGLTMWSHNQWQ.....QDFYGSGTK....PAERLEKYAQV--FHTVEGNTTFYATPNTPTV
  63 NIHIGIGGWTYAPWR.....GTFYPSDLT....QSRELEYASRN--LTSIEINGTFYGLQKPASY
  64 --WLGCAVWAYRNWV.....GSFYPPGTG....SDAFLRCYGER--LTAVEGNTTFYSIPSTETV
  65 NIHIGIGGWNYAPWR.....DNFYPAGLA....QARELEYASRH--LTAIEINSTYHGTQKRTSF
  66 -LRLGLTMWSHNQWQ.....QDFYGSGTK....PAERLEKYAQV--FHTVEGNTTFYATPNTPTV
  67 MIYIGLPQWSHPKWV.....RLGITS---....----LEEYARH--FNCVEGNTTLYALPKPEVV
  68 -VRIGISGWRYEGWR.....GVFYPKGLA....QRRELEYASRQ--VESIEINGSHYSLQSIKSW
  69 -LFVGTSGWQYRDWR.....ESFYPPGLP....VRRWLEHYAAA--FATVEINNAFYRLPARETF
  70 MIYIGLPQWSHPKWV.....RLGITS---....----LEEYARH--FNCVEGNTTLYALPKPEVV
  71 -IYLGTGGYSDTDLI.....GTLYPHGTS....KTDFLNIYSRH--YDTIEINSTFHAPIGEKAL
  72 MITIGLTTWTEHPSLl....------GGT....EKLTLTEYSGV--LPVVEVDTPFYGIPKVTTV
  73 MIYIGLPQWSHPKWV.....RLGITS---....----LEEYARH--FNCVEGNTTLYALPKPEVV
  74 -IRVGIGGWTYAPWR.....DNFYPAGLA....QTRELEYASRH--LTAIEINSTYHGTQKRTSF
  75 MIYIGCSGWFYLHWY.....KKFYPGDLK....KSQWFKYYTSK--FNTVEINSTFYRMPDERTF
  76 -IRSGMGGWTFEPWD.....TSFYPDKLS....KAKQLQYASRQ--VPSIEVNGTYYSSFKEPTF
  77 --RTGCSGWSYDFWK.....GKIYDYSES....PSNYLRDYARI--FDTVEIDSTFYAAQSQETV
  78 MIQIGLSTWADHPAL.....SV----EGK....PKSTLEEYVGH--FPIVEVDSSFYAIPSLSNV
  79 -VYCGCAGWSIPAAE.....RAQFGAG--....-SSVLQRYATR--LNAVEINSSFYRPHRTSTY
  80 --SIGAPVWSCDGWG.....DVVYPKKTP....RTEWLSWYTRS--FNTVEGNSTFYAVPGEQTF
  81 -IYVGCQGWRYPDWRl11lsAPFYPPRLP....AARELKHYART--FDLVEVDSTFYAVPQIRVV
  82 NILIGTASWTDPTLLac...GRFYPAAARt...PQARLQYYATR--FGMAEIDASFYALPDPHTA
  83 -IRTGIGGWTFEPWR.....GTFYPDDLK....QKDELKYAASK--LTSIEINGTYYSTFKPNSW
  84 --FIGTAGWGIPT--.....--RYKEDLPq...PGSHLERYARH--LPIVEIDTSFHKPHRRETY
  85 MIHLGCSGWSYDEWE.....KVFYPEHT-....-ADRLSFYSMI--FNTVEVDSTFYRIPPKNVA
  86 MIYIGLPQWSHPKWA.....RLGITS---....----LEEYARH--FNCVEGNTTLYALPKAEIV
  87 NILIGTASWTDPTLLac...GRFYPAAARt...PQARLQYYATR--FGMAEIDASFYALPDPHTA
  88 -IFIGCAGWSLPR--.....-EYWPDFPE....QGTHLQRYAAL--LNGVEINSSFYRPHKLQTY
  89 MIFVGCSGWSYEEWN.....GVFYPK--S....KINKLKFYSTM--FNTVEVNSTFYREINNDII
  90 -VRCGCAGWSIPAAD.....RAQFDEG--....-ASVLQRYATR--LDAVEINSSFYRPHRASTY
  91 -IHIGIGGWVYAPWRa....GMFYPDGLV....QRRELEYASRH--VTAIEINGTYYGTQKPATY
  92 NILIGTASWTDPTLLac...GRFYPAAARt...PQARLQYYATR--FGMAEIDASFYALPAPHTA
  93 -IHVGIGGWVYAPWRa....GMFYPEGLV....QRRELEYASRH--VTAIEINGTYYGAQKPATY
  94 --ALGTAGWGLSREQ.....QERFGPG--....-DSVLQRYATR--FNAAEINSSFYRPHRPATY
  95 -LYIGCSGFSYRDWK.....GTFYPSHIP....ESEMIIYYEQF--FNVVEINYTYYTMPHPYTF
  96 -LRIGTAGWSIDK--.....--RYADGLPa...PGSNLERYARR--LNAVEINSSFRRRHKPSTY
  97 -IRCGTAGWTDRTLIac...KRFYPRGSSs...AEARLRFYASQ--FPLVEVDSAYYAMPSASNA
  98 MIRIGIGGWVFEPWR.....GTFYPEGLP....QKRELGHAASR--LTTLEINGTYYGSQKPESF
  99 -ILVGACSWTDRQLLa....SGWYPRGRRd...AEGRLRHYASR--LPVVEVDAGYYALPSRRNS
 100 ---------------.....---------....--DYLGHYGGI--FNAVEGNTTFYARPSAETV
 101 ---------------.....---------....----LEEYARH--FNCVEGNTTLYALPKPEVV
 102 -PIIATAAWSIPKKV.....ASRFPEE--....-GSGLQRYASV--FDGVEINSTFYRRHKTSTF
 103 ---IATAAWSIPKKV.....ASRFPEE--....-GSGLQRYASV--FDGVEINSTFYRRHKTSTF
 104 --YIGLPQWQHPAWG.....RLG------....-LRDLADYSRY--FNCVEGNTTFYALPRPEIV
 105 -IYVGTSGWLYSW--.....--------N....LGKSLKWYVENSGLNSVELNSSFYRMPSEKQV
 106 MIFVGTSGWMYDW--.....--------N....EGGNLEWYVKYSGLNAVELNMSFYRFPFENQI
 107 -LRLGLAMWSHYHWQ.....DSVYGSTTK....QAERLARYATI--FNTVEGNTSFYATPNAQTM
 108 ---------------.....---------....-------YSQH--YDAVEINSTFHAPIGAKSL
 109 --FVGTSGWYYEW--.....--------N....KKKNLDWFVENSGLNSVELNASFYRFPFPGNV
 110 -LYFGTSSWSYPGWH.....GITYDGQYTesllSRKGLRACGQHPLLRAAGIDRGFYGPIPLADY
 111 -VRLGTSSWTFPGWD.....GIVYDGDFAqtklSREGLEAYGAHPLLKSVSLDRSFYGPLSVADY
 112 MIRVGTCGFCEGK--.....---------....-----RKYFKD--FDTVEIQQTFYRIMQERTL
 113 -VYVGCAKWNKTDLK.....N-FYPKGT-....-KDELQYYATQ--FNSIELNATFYKSPSKDQV
 114 --FVGTSGWYYEW--.....--------N....KKKNLDWFVENSGLNSVELNASFYRFPSSNNI
 115 -LRIGTSSWSYPGWE.....GLVYGGGYSesqlARKGLAAYGQHPLLRTVSIDRGFYAPIPLADY
 116 --FVGTSGWYYDW--.....--------N....KKKNLDWFIQNSGLNSVELNASYYRFPSPEQI
 117 -VRLGTSSWYFPGWN.....GIVFDGDFAqsklSREGLGAYGAHPLLRSVSLDRSFYGPLSVADY
 118 -IHLGTSTWSFPGWN.....GIVYGDEYSnsklSREGLTAYGAHPLLKTVSIDRSFYQALTVTEY
 119 MIHVGTCGFCEKQ--.....---------....-----DKYFQD--FSTVEIQQTFYKILQESTL
 120 -IFVGTSGWTYDW--.....--------N....DDDTLEWYVKNSGLNAVEVNMSFYRYPTRKQV
 121 MIHVGTCGFCEAR--.....---------....-----EKYFKD--FDAVEVQQTFYKVLQEKTL
 122 -LYLGTSSWSYNGWN.....GLVYDGEYSdnllSRKGLAAYSRHPLLRAAGIDRGFYGPIPLADY
 123 --KVGCCGFPVSM--.....---------....-----KRYFET--FDVVEVQKTFYKPPEVKTA
 124 ---------------.....---------....-------------LDAVEVQQTFYDPPPRSRL
 125 -VLVGTCGFPKSR--.....---------....-----RAVYSA--LDAVELQETFYNMPNSERM
 126 MIKVGTCGFTYKHFK.....Y--------....-------------FDVLEVQQTFYDIVSESQL
 127 MIKIGTCGFTRKHFN.....Y--------....-------------FDVLEVQETFYNFLSEERL
 128 --FVGCAKWNKTDLK.....G-FYPKGT-....-KDELSYYSTQ--FNSIEMNATFYGMPTPDQV
 129 ---------------.....---------....--------------------------------
 130 ---------------.....---------....-----------------EGNTTLYALPKPEVV
 131 ---------------.....---------....--------------------------------


        60              70        80             90           100      
        |               |         |              |             |      
   1 VQMLR.KT....PPD.FYFTVKTPGSVTHV.....LWKEGKDPKEDMENFTR....QIEPLI.EE
   2 VQMLR.KT....PPD.FYFTVKTPGSVTHV.....LWKEGKDPKEDMENFTR....QIEPLI.EE
   3 TKWAM.ET....PKD.FSFIVKAYQGMTGHmk...GEIPFSTFDEMFDVYKQ....SILPLI.EA
   4 TKWAM.ET....PKD.FSFIVKAYQGMTGHmk...GEIPFSTFDEMFDVYKQ....STLPLI.EA
   5 TKWAM.ET....PKD.FSFIVKAYQGMTGHmk...GEIPFSTFDEMFDVYKQ....SILPLI.EA
   6 ANWAA.QT....PDD.FRFVIKAFSAMTKHke...WSQYFDSENAMYTAYMD....MIAPIS.ET
   7 MKWYT.ST....PEG.FIFSVKASRHITHL.....--KKLCDVEEAWNNFKK....RIDLL-.-K
   8 EKWAS.DT....PEC.FRFVVKAYQGLTGHqr...GEIPFSSKEEMFAAFVE....SLQPLL.ES
   9 ANWAA.QT....PDD.FRFVIKAFSAMTKHke...WSQYFDSENAMYTAYMD....MIAPIS.ET
  10 QKWVS.ET....PDD.FRFIVKVHRAMSGH.....DRENKDPLGPIFEQYLA....SIEPMR.QS
  11 TKWAM.ET....PKD.FSFIVKAYQGMTGHmk...GEIPFSTFDEMFDVYKQ....SILPLI.EA
  12 EKWVK.ET....PET.FQFIVKAYQGMTGHqr...GEIPFDSKEEMFDAFKV....SLTPYL.HS
  13 ANWAA.QT....PDD.FRFVIKAFSAMTKHke...WSQYFDSENAMYTAYMD....MIAPIS.ET
  14 RSWVK.GS....PEN.FVFSVKVNRTITHV.....--KRLKDCDEEIGLFYE....IIGSL-.-G
  15 ANWAA.QT....PDE.FRFVIKAFSAMTKHke...WSQYFDSENAMYTAYMD....MIAPIS.ET
  16 RRLYR.ET....PKD.FKFSVKVNRNITHY.....--RKFKDVKELIKNFYE....VCRNG-.LR
  17 ANWAA.QT....PDE.FRFVIKAFSAMTKHke...WSQYFDSENAMYTAYMD....MIAPIS.ET
  18 EKWIK.ET....PEK.FQFVVKAYQGMTGHqr...GESPFESKEAMFEAFKE....SMIPFQ.KT
  19 IKWIN.ET....PNR.FQFVVKIHQALTLHad...YRDYAESRDILFKQFKE....MINPLK.EH
  20 EQMAR.KV....PEG.FIFAVKAYRTLTHD.....---RGESVTDDSKQFRQ....ALQPLV.DQ
  21 QSWHD.ET....PDD.FVFAVKGPRFVTHM.....--KRLRDCEQALANFFA....S-GVLR.LG
  22 AGWRR.RT....PRG.FVFAAKASRYLTHM.....--KKLREPEEPLRRLFG....RLEAL-.-G
  23 QRWHD.ET....PED.FVFSVKGPRFITHM.....--KRLRDCEQALANFFA....S-GVLR.LG
  24 ARWNE.QT....PDD.FVFAVKGSRYITHM.....--KRLKDVETPLANFLA....S-GVLR.LG
  25 LGWRE.AT....PEG.FVFAVKGPRYITHV.....--RRLKEIEEPVANFFA....S-GPLL.LG
  26 RGWAE.DT....PED.FVFSVKAPRYITHV.....--RRLREIDEPLANFFA....S-GPLA.LR
  27 AQWYA.ET....PDD.FVFSIKAPRFITHI.....--RRLRDIEKPLANFFA....S-GVLE.LK
  28 LKWIK.ET....PDT.FEFVVKIHQALTLHad...YKTFADTRQELFDQFKN....MLEPLH.TQ
  29 LHWYS.ET....PED.FVFSVKGPQYITHI.....--RRLKDVEMPLANFFA....S-GVLH.LR
  30 QNWKA.AT....HDD.FKFTFKLPKAITHE.....--QMLRGCNEQLRDFMK....IMEPL-.-H
  31 QRWAE.TM....PED.FRFTAKFHKDISHN.....--GDLRQQVGAAEAFIR....LLAPL-.-G
  32 ETWHK.QT....PSN.FLFAVKGSRYLTHM.....--KKLKDPIEPLSRIME....RASGL-.-Q
  33 AGWRE.QL....PDG.FTMSVKAHRGLTHY.....--RRLASPEPWIERFER....CWELL-.-G
  34 ERWRG.IS....PEG.FLFAAKFPREITHE.....--RRLAGAEGEARRFVE....TMALL-.-G
  35 RRWAE.TM....PAG.FRFCAKFPRDISHE.....--GDLRERLEAAGDFLE....LLAPL-.-G
  36 TRWAA.ET....PAG.FEFCLKLPRDITHQ.....--GLLQPYIPAALKFLE....GMRPL-.-G
  37 QRWAE.IM....PDD.FRFTAKFHKDISHN.....--GDLREQVGAAEEFIR....LLAPL-.-G
  38 AEWVK.AV....PEN.FRFVMKVYSGISCQge...WQTYYASEEEMITAFLE....SMAPLI.ES
  39 LNWRA.AT....HDD.FRFTFKLPKSITHQ.....--HLLRDCKEELLSFLR....LMQPL-.-H
  40 KKWHD.AT....PSD.FRFTFKLPSTITHQ.....--NQLMHCDQLLADFLN....VMAPL-.-E
  41 RKWAS.EV....PDD.FVFSLKGPRFATNR.....--KVLAEAGDSIERFYH....S-GVLE.LG
  42 SRWAK.ET....PPG.FEFCLKLPRDITHQ.....--GLLKPYIPAALTFLA....GMRPL-.-G
  43 LGWYN.SS....PEN.FTYSLKINRSITHI.....--KRLRDTDEEILKFYN....VAGKL-.-K
  44 AKWAA.EV....PDG.FIFSLKASRFVTNR.....--RVLSEAGESMERFLT....Q-GLTE.LG
  45 AKWAA.ET....PDG.FVFSVKAIRFATNR.....--RVLGEAGESITRFLE....S-GPAV.LG
  46 SRWAK.ET....PPG.FEFCLKLPRDITHQ.....--GLLKPYIPAALKFLE....GMQPL-.-G
  47 ASWRR.RL....PEG.FALSVKAPRGLTHA.....--KRLQAPEAWAQRMSA....SWHEL-.-G
  48 QRWAQ.RM....PAH.FRFCAKLPRDISHS.....--AELRLQMPAARAFVE....SLAPL-.-G
  49 AKWAS.EV....PDD.FIFSLKASRFVTNR.....--RVLAEAGESMTKFLT....Q-GLTE.LG
  50 AKWAS.EV....PDD.FIFSLKASRFVTNR.....--RVLAEAGESMTKFLT....Q-GLTE.LG
  51 EGMVR.KS....GGW.VRFAVKLNKVFTHV.....----RAPTDTDFDRMLQ....SPEPLR.EA
  52 ARWAQ.LM....PEH.FRFTAKFPRDVSHE.....--GDLRDQLEPAFDFTR....LMAPL-.-G
  53 KTWYD.KT....PAD.FRFSLKANNQITHY.....--KKFNGTQSLISELYE....VAAAG-.LK
  54 ETWRE.RT....PPD.FVVAVKASRYLTHI.....--KRLRDPEEPVHRLMT....HAAGL-.-G
  55 ASWRE.QT....PEG.FLFAVKGGRFITHL.....--KKLRDVEAPLANFFA....S-GVLA.LG
  56 QRWAE.VM....PEH.FRFTAKFPGDISHS.....--GDLRDQLTAAETFLQ....LLKPL-.-G
  57 RKWAS.EV....PEG.FVFSVKGPRFATNR.....--RVLAEAGDSIKRFYD....S-GVLE.LG
  58 RKWAE.RT....PEG.FLFHVKAYSAFTGHg24sqREVPEEVVEEAWNRFFA....SLAPLR.EA
  59 ENWIS.EV....PES.FRFVVKVYQGISGQgd...WKPYYQTEEEMIAHFLD....VMSPMV.DA
  60 AGMVN.KAytesNSE.LIFAVKLHQDFTHA.....----RKGTAEHAQAFLT....ALTPLI.EA
  61 RRWYD.ET....PPG.FTFAVKGARYLTHM.....LRFRDETATVACANFFA....Q-GLLA.LN
  62 LNWRA.AT....HDD.FRFTFKLPKQITHQ.....--QMLKGSQGLLREFLS....VMEPL-.-H
  63 EKWYQ.ET....PDD.FVFSLKAPRYATNR.....--KVLADAGETIERFFG....S-GVLL.LK
  64 QRWRQ.ET....PDR.FRFCLKLPRSLSHA.....--GPLAAQIEAAAAFRR....QLQPL-.-G
  65 ANWRD.AT....PDG.FVFSVKASRFATNR.....--RVLAEGSDSISRFID....S-GIAE.LR
  66 LNWRA.TT....HDD.FRFTFKLPKQITHQ.....--QMLKGSQGLLREFLS....VMEPL-.-H
  67 LRWRE.QT....TDD.FRFCFKFPATISHQ.....--AALRHCDDLVTEFLT....RMSPL-.-A
  68 RAWHD.AV....PDD.FVFAVKGPRYLTHL.....LRFRDEKAVPALANFFA....S-GVLA.LR
  69 TAWRD.RV....PPD.FTVAVKASRYLTHI.....--KRLRDPAEPVDRLMT....HAAGL-.-G
  70 LRWRE.QT....TDD.FRFCFKFPATISHQ.....--AALRHCDDLVTEFLT....RMSPL-.-A
  71 QGMVE.KA....EDR.LKFSVKLHQNFSHQ.....----RIATETQASLFLN....ALQPLI.ER
  72 AKWQK.AV....PDK.FQFILKANQVMTLHdtyd.EGVSMDALKTAYREYRA....MLKPLT.QH
  73 LRWRE.QT....TDD.FRFCFKFPATISHQ.....--AALRHCDDLVTEFLT....RMSPL-.-A
  74 AKWRD.ET....PDD.FVFSVKASRFATNR.....--RVLAESGESIARFID....S-GIAE.LG
  75 KNYYR.NS....PEN.FVYSVKMNKLVTHI.....--NKLNDPAELINSFIK....NVSIL-.-K
  76 VKWAS.EA....PDG.FVYSLKGNRFVTNR.....--RVLGEAGESMMRFLG....S-GVAA.LG
  77 EKWAS.SV....PEN.FLFSPKMPRKITHE.....--FRLERCEDDLAYFMK....NISLL-.-N
  78 VNWQH.QV....PDN.FKFIFKASRVMTLHdgvdgDEYLTPERRIEFTNFKK....VMQPLI.QN
  79 ARWAD.SV....PTH.FRFSVKLPRSISHD.....--ARLHQAGPLLDAFLA....QAGAL-.-G
  80 RGWAE.QA....ADG.FEFCFKFPKRISHD.....--SMLQHCDDEVREFLV....RLRVIA.KE
  81 KNWAT.QV....PET.FRFTLKLPRTLTHE.....--YRLARGRATLSAFCE....CARPL-.-G
  82 YLWAQ.RT....PPG.FVFNIKAFRLFTGHq24fdDQVPGAVRDELWRRYVQ....ALEPLR.QA
  83 MKWRD.ET....PDD.FVFSVKASRFCTNR.....--RVLSENNDSLEKFLS....Q-GLEE.LG
  84 ERWAR.SV....PEH.FRFAVKTPKAMTHE.....--HRLAGGDALAEMFLQ....QVEGL-.-G
  85 RQWGK.AMs...GKH.FLFAVKVPGDITHD.....--AIFTDMDRSCSIFRTfeqnVLNELS.TS
  86 DRWYA.QT....TDD.FRFCFKFPATISHQ.....--AALRHCDDLVQAFFT....RLAPL-.-E
  87 YLWAQ.RT....PPG.FVFNIKAFRLFTGHq24fdDQVPGAVRDELWRRYVL....ALEPLR.QA
  88 ARWAE.SV....ADG.FRFCVKMPKSISHE.....--RRLRDCESELDAFLK....QCSGL-.-G
  89 NRWIE.TVr...GKN.FIFSIKVPQNITHKa....ILEKDSNSKSLYETFIDk...TVRPIR.NA
  90 ARWAD.SV....PED.FRFSVKLPRSISHD.....--ARLHGTGPLLDAFLA....QAGAL-.-G
  91 AKWRD.EV....PPG.FVFSAKAPRRITQS.....--RKLAGTQAQVEDFIG....GIVEL-.-G
  92 YLWAQ.RT....PPG.FVFNIKAFRLFTGHq24fdDQVPGAVRDELWRRYVL....ALEPLR.QA
  93 AKWRD.EV....PPG.FVFSAKAPRRITQS.....--RTLAGTGAQVEDFIG....GIAEL-.-G
  94 ARWAA.SV....QQG.FRFSVKVPKAVTHT.....--ARLRECAAPLAEFVE....QVSHL-.-G
  95 QSFLE.KT....-KR.LRFAVKANQVFTHE.....----RNYTKEDVKKFIE....GIKPLLeEE
  96 ERWAS.SV....PEE.FRFSVKLPEEITHD.....--RGLVGCDEILKIFAA....ETAGL-.-G
  97 QLWSE.RT....PEG.FTFNFKAFRLFTGHq29yyRDMPAEIRDELWRRYRE....ALEPLR.LS
  98 ARWHD.EV....PDD.FVFALKAPRFATNR.....--RKLAEAGASVDRFLN....S-GILR.LG
  99 ELWVE.RT....PDG.FRFDVKAFSLLTGHp21rrGRAGEGLLDEVWGRFAE....GIEPLR.KA
 100 RRWAE.TM....PAG.FRFCAKFPRDISHE.....--GDLRERLGAADDFLE....LLAPL-.-G
 101 LRWRE.QT....TDD.FRFCFKFPATISHQ.....--AALRHCDDLVTEFLT....RMSPL-.-A
 102 ARWAG.FV....PDG.FRFSVKMPKEISHT.....--RAMIDVAEPFCSFIE....DIAPL-.-G
 103 ARWAG.FV....PDG.FRFSVKMPKEISHT.....--RAMIDVAEPFCSFIE....DIAPL-.-G
 104 LRWRD.MT....PDS.FRFCFKFPATISHQ.....--AALRDCDKELQAFYH....CLAPL-.-N
 105 RSWAE.A-....GRG.LRWAVKVYRGVTHY.....-RKLSERALELLRRFLA....LFRPM-.-E
 106 KGWSK.Y-....--K.IVWSIKVNRYITHV.....--KRLKDI-ESWEKFRK....LMDKI-.--
 107 MNWLR.AT....PDD.FRFTFKLPQTITHQ.....--KQLQHCQQELLQFFQ....VMSPL-.-A
 108 LGMVE.KA....QGR.LQFSVKLHQDFSHK.....----RTATREQAKVFLA....ALQPLK.DQ
 109 KSWGE.K-....GKG.LRWSVKVHRSITHW.....-RQFGESALEIWENFRE....LFKPM-.-D
 110 LNYAS.QV....PED.FRFLVKAPASVCDAw11rlQNAAFLNAEIAIRDFIE....PATSG-.LG
 111 LRYAQ.QV....PDD.FRFVVKAPASVTDAv11sgPNPTFLDADLATREFVQp...CLDGL-.-G
 112 RRWKE.EA....PEG.FTFSIKAFQGITHPp18vgLLKPTSEVFHYWRLTLK....EAEVL-.--
 113 QTWKA.KA....AKG.FKFFPKIPNTISHF.....--KRLVGVETIVEEFCD....AVVLF-.-E
 114 LNWST.K-....GAE.LRWSIKVHRSVTHW.....-RQFGESALETWENFRE....LFEPL-.-D
 115 VAYAA.SV....PDD.FRFAVKAPAAVCDAw11rqPNPAFLNAEFAVRDFVE....PATRG-.LD
 116 EGWNS.K-....GTG.LRWSIKVHRSITHW.....-RQLSESSLETLGNFLE....LFRPM-.-D
 117 LRYAQ.QV....PDD.FRFVVKAPASVTDAv11sgPNPTFLDAALATHEFVQp...CIDGL-.-G
 118 LRYAQ.QV....PEH.FRFIVKAPMTITDAt11vsMNPCFLNAQMAIDDFVTp...CLEGL-.-G
 119 KKWRE.KA....PEG.FVFSIKAFQGVTHPp18vgLLRPTNEVIHYWKITLN....EAKIL-.--
 120 ERWSK.F-....-KE.IRWIVKVNRRITHM.....--KRLKDF-QSWKEFQQ....IVDSL-.--
 121 ERWRK.KA....PEE.FTFSIKAFQGVTHPs18vgLLRPTNEVLHYWRITLK....EAKVL-.--
 122 LSYAA.QV....PEQ.FRFLVKAPASVCDAw11rlANAAFLDAEIAIRDFIT....PATSG-.LG
 123 EKWRK.SA....PED.FEFTIKAWQVITHPp17cgFFRPTEVVFMAWEETKK....IAKAL-.--
 124 DSWRS.EA....PED.FEFTVKAWMLVTHGy21ygGFKLTRENLWAWSVTLE....AAEAL-.--
 125 AQLRR.EA....PE-.FRFTAKVFQGITHSp19hgMLKPTRENLQLWEQFAE....AVSPL-.--
 126 QNWRK.KA....EENkVELTIKALQVITHEy20ygFFKNTKEVEEATEITLK....EAKLL-.--
 127 NKLKElSI....RNK.VELTIKANQIITHEy20ygYFRPTKEVMQALEITLN....EAKFL-.--
 128 FVWKN.KT....PDS.FKFFPKITNTVSHF.....--RRLKDVTEPVTQFAS....AIMNF-.-G
 129 -----.--....---.--------------.....--------EEAWNRFFA....SLAPLR.EA
 130 LRWRE.QT....TDD.FRFCFKFPATISHQ.....--AALRHCDDLATEFLT....RMSPL-.-A
 131 -----.--....---.--------------.....-----------------....------.--


        110       120            130                 140       150     
         |         |              |                   |         |     
   1 QRLKMTLAQFPFSFKF.....SRKNVEYLEKLRES.....Y.....PYELAVEFRHYSWDREE..
   2 QRLKMTLAQFPFSFKF.....SRKNVEYLEKLRES.....Y.....PYELAVEFRHYSWDREE..
   3 SKLKTILFQYPPWFDC.....KKKNVDFLRYTKEK.....Me....GLPCAIEFRNQTWFYPEmr
   4 GKLKTILFQYPPWFDC.....KKKNVDFLRYTKEK.....Me....GLPCAIEFRNQTWFYPEmr
   5 GKLKTILFQYPPWFDC.....KKKNVDFLRYTKEK.....Me....GLPCAIEFRNQTWFYPKmr
   6 GKLQAILFQFPPYFNC.....TKENVTYLKYIASK.....Mg....DLPVAVEFRHNSWYNEQnt
   7 DKLGPILLQFPPSFKK.....DQENVEKIINFLRG.....Ke....NYKFALEFRHKSWLDEE..
   8 NKLAMVLFQFPPWFDC.....TKEHVRYLRYCKQQ.....Mg....EIPVALEFRHQSWFRPSvr
   9 GKLQAILFQFPPYFNC.....TKENVTYLKYIASK.....Mg....DLPVAVEFRHNSWYNEQnt
  10 GKIAAILVQLPPWFDV.....SKVHLEYLQTIRKS.....La....GLPVAIEFRNPSWYSDAyq
  11 GKLKTILFQYPPWFDC.....KKKNVDFLRYTKEK.....Me....GLPCAIEFRNQTWFYPEmr
  12 NKLAMVLFQFPPWFDC.....KKENVAYLRWCKHQ.....Mg....DIPCALEFRNRSWFSPPfy
  13 GKLQAILYQFPPYFNC.....TKENVTYLRYIASK.....Mg....DLPVAIEFRNNSWYSEQnt
  14 KMLGCVLFQFPPSFKY.....SHDNLIMIEKALDQ.....-.....RFCNVVEFRNISWFSED..
  15 GKLQAILFQFPPYFNC.....TKENVIYLKYIASK.....Mg....DLPVAIEFRHNSWYNEQnt
  16 EKLGCVLFQLPPSYTY.....TKENLERILENLDF.....-.....GFKNVLEFRHISWWNEE..
  17 GKLQAILFQFPPYFNC.....TKENVTYLKYIASK.....Mg....DLPVAIEFRNSSWYNEQnt
  18 GKLATVLFQFPPWFDC.....KKEHVQYIRYCKKQ.....Mg....DIQVALEFRHQSWYSDSfr
  19 NKLAMVLVQFPPWFDC.....NVQNINYILYVRKQ.....Lt....DIPMSIEFRHQSWFDNQyk
  20 GRLGAVLLQFPYSFHN.....NQANREYLARLREL.....Lp....DLPLVVEFRHAGWVHDA..
  21 EKLGPILWQLPPTLRF.....DDAVLDAFLSSLPRd28rk-r....PLRHALEMRHPSFCDPS..
  22 EKLGPVLFQLPPRWRA.....NPGRLEALLKALPP.....-.....GRRCAFEFRDESWFCEE..
  23 AKLGPILWQLPPTLQF.....DAELLDAFLGSLPRd28rr-r....PIRHALEVRHDSFCDPA..
  24 AKLGPILWQFPPQMRF.....DPERFEPFFKLLPKt27gr-r....PLRHAVEIRHESFCTGK..
  25 EKLGPFLWQFPPSMKF.....DEDRFARFLELLPHt27gn-a....RLRHAVEIRHESFLCEA..
  26 QRLGPFLWQFPPSMRF.....DRELFADFLARLPRd27pa-q....RLRHAVEIRHESFVDPT..
  27 EKFGPILWQFPPNFTF.....DPERFEAFLDQLPHd27gk-k....PLRHAVEIRNDSFIDPD..
  28 KKLAMVLVQFPPWFDC.....NAQNIKYILYVRQQ.....Lq....AFPMCVEFRHQSWFSDAfk
  29 EKLGVFLWQLPPNFVF.....NPEKEDRLETFFRLl30ik-k....QIRHAIEVRHHSFENPE..
  30 ERVGQWTIQLPAAF--.....GPEYLERLKKFCAS.....Fpp...NFPLGVEVRHMAFFSKGee
  31 GRIAPFWLQLPASF--.....TPQRLAELVGFIDE.....L.....NVPLAVEVRNMAFFMKGde
  32 EKLGPILFQFPHTWHI.....NIERLQPFLELLQT.....Yp....KQKFTVEFRHSSWLIPQ..
  33 DRRGVLLVQLHPEQQR.....DDARLDSFLERMPA.....-.....SIRVAVELRHPSWNDPA..
  34 DRLGPLLVQLPPSF--.....DVEGMGVLEDFLGS.....Lpg...GFRYAVEVRHSSWLRSG..
  35 ERVSPLWLQLSAAF--.....TPQRLGELLYFLDE.....Ls....PRRIAVEVRHPAFFDKGed
  36 KHLGPIFAQLPPSY--.....APALFDDLTNFLEA.....Wprt..DAPLALEVRHPDWFREPha
  37 GRIAPFWLQLPASF--.....TPPRLAELAGFLDE.....L.....KVSVAVEVRNMAFFMKGde
  38 KKLFAFLVQFSGTFGC.....TKENVAYLQKIRHW.....Fk....DLPIAIELRNNSWYQPNfv
  39 DRIGMWTIQLPAAF--.....GPEHLAQLKNFRDW.....Fpa...DFPLGVEVRHLAFFGKGea
  40 SKVGLWKIQLPANF--.....GPDALPALKKFLQK.....Ipk...HLTYGVEVRHYAFFNKGda
  41 DRLGPVLWQFAPTKKY.....DEADFGKFLELLPR.....Eidgr.KLRHVVEVRHDSFKTPA..
  42 KRLGPIFAQLPPSY--.....APTLIEDLAAFLEA.....Wprt..TAPLALEVRHPDWFREPht
  43 EKLGCLLFQFPPSFKY.....SEENVSLIAKIPLS.....-.....KYCRVLEFRHKSWFDKK..
  44 DRLGPILWQFAPTKKF.....DAEDFEGFLKLLPE.....Kqdgl.KLRHVVEVRNPSFQVPD..
  45 EKLGPIVWQFAPTKKF.....DPEDFESFLKLLPE.....Kqdgv.PLRHVLEVRHASFVAPE..
  46 KHLGPIFSQLPPSY--.....APTLIDDLASFLEA.....Wprt..TAPLALEVRHPDWFREPhk
  47 PRRAVLLVQLRPDHAR.....DDDRLRSFLDRLPP.....-.....WMRVAVEFRHPSWHEEA..
  48 ERVTPFWLQLPASF--.....GPARLGELADFLAG.....F.....ERPLAVEVRHPAFFQRGee
  49 SHLGPILWQFAPTKKF.....DADDFGAFLALLPE.....Kqdgi.SLRHVVEVRNETFQVPE..
  50 SHLGPILWQFAPTKKF.....DADDFGAFLALLPE.....Kqdgi.SLRHVVEVRNETFQVPE..
  51 GMMGPYLAQFPYSFHR.....TAANRKYLALLTER.....Fa....GHELAVELRHASWDKPE..
  52 RRVSPYWLQLPAQF--.....GPARLGELCHFLDQ.....I.....AVPVAVEVRNQAFFAKGee
  53 DKLECILFQLPPSVKY.....TPEILERIVSQLDP.....-.....AFKNVLEFRDAGWWNNE..
  54 DRLGPVLVQLPPTLRA.....DPGLLDACLACFPS.....-.....GTRIAVEPRHDSWWAPA..
  55 DRLGPVLWQLPERVHF.....DAGVLDAFLAQLPRt31ed-r....RVRHTLEPRHESFGSEE..
  56 ERVSPMWLQLSKSF--.....TPHRLPELAAFIDA.....L.....DCPLAVEVRHEQFFAKGes
  57 DHLGPVLWQFAPTKKF.....DGADFGKFLELLPR.....Kldgr.ALRHVVEVRHDSFCTPD..
  58 GKLGYLHFGLPPWTEP.....KPRSFRYLERLAER.....Tq....GYLVAVEFRNPRWYTAWgf
  59 GKMFCFLVQFPSSFKC.....TKENVQYLRKLRKW.....Fe....GYPVSIELRDYSWYSDEfl
  60 DCLAPLLLQFPHGFDR.....TRDHRLYLANLVSW.....Fk....DYPLAIEFRHNGWHTPQ..
  61 DKLGPLLWQFPPSLRF.....DPDHMEHFLGLLPHd26rk-r....ALRHAIEVRHASFVDPA..
  62 PRIGQWTIQLPAAF--.....SPEHLPLLQRFCSY.....Fpe...GFPLGIEVRHLAFFAKGed
  63 QKLGPINWQFAPTKKF.....DSEEFEAFLKLLPA.....Siegq.KLRHAIEVRNDTFKTPE..
  64 DRLGPAFLQLPPRY--.....GPGAIADLSQFLAA.....Wpvv..QWPLAVEPRHPDWFQPQpr
  65 EKLGPVVWQFAPTKQF.....VADDFEAFLNLLPT.....Svegv.KLRHVMEVRHESFMCDA..
  66 PRIGQWTIQLPAAF--.....SPEHLPLLQRFCSY.....Fpe...GFPLGIEVRHLAFFAKGed
  67 PRIGQYWLQLPATF--.....GPRELPALWHFLDS.....Lpg...EFNYGVEVRHPQFFAKGee
  68 HKLGPFLWQFPPNYRF.....DAERFDRFLSLLPSd26gd-r....PLRHAVEVRHESFCTDA..
  69 DRLGPVLLQLPPTLRA.....DPDLLDACLACFPP.....-.....GTRVAVEPRHESWWTAE..
  70 PRIGQYWLQLPATF--.....GPRELPALWHFLDS.....Lpg...EFNYGVEVRHPQFFAKGee
  71 NCLANLFIQFPHTFER.....TTANRLYLAQLTKW.....Fn....GFSLAVEFRHSSWHIAQv.
  72 QQLKAVLFQFPPFFER.....SNRNFHYLQRMVEW.....Lp....GVPIAVEFRNQSWYEESvk
  73 PRIGQYWLQLPATF--.....GPRELPALWHFLDS.....Lpg...EFNYGVEVRHPQFFAKGee
  74 PKLGPLVWQFAPTKQF.....DAEDFEAFLQLLPD.....Svegv.TLRHVLEVRHDSFLSPD..
  75 EKLKCVLYQMPPSFKR.....SDENIKNIIENIPG.....G.....SF---IEFRSRSWDPKS..
  76 DKLGPILWQFAPTKKF.....DPDDFEAFLKLLPE.....Kqdgv.ALRHALEVRNDSFFVPE..
  77 NRLGTVLIQLPPDFPF.....NTGVLENFIELLPN.....-.....NIKYAIEFRHPSWFIDE..
  78 GQLESVLFQFPPSFRC.....DLTNIRYLFEIRQM.....Md....RIPISVEFRNPSWFIEAve
  79 ERLGCLLLQLPPSAVF.....DARVAASFFAVLRR.....Rw....DGAVVCEPRHPSWFTAQ..
  80 NRLGPTFLQLGPNF--.....GPDRLPILAKFLRR.....Lpr...ELPWAVELRHHDWFDSAdn
  81 VQLAAILIQLPPSF--.....ATDEFAALERFLPH.....Lpa...DLPFAVEFRDPAWLSER..
  82 GKLGAVHCQFAPWVRR.....EARGVARVRDCAAR.....Lrdag.GLVMAAEMRHASWFDSAaa
  83 PKLGPINWQFMATKKF.....DPADFEGFLKLLPS.....Eqkgv.RLRHAMEVRSPTFACQQ..
  84 EKLSVLLVQLPPSLPF.....EPDIACGFFDMLGR.....Rt....KARLACEPRHPSWFEAE..
  85 GVLGPILFQMPPRF--.....SVDNVERLISFMEC.....Vh....VRNAAVEVRNMTLYENRk.
  86 TRIGQYWLQLPAAF--.....GPRDLPALWQFLDA.....Lpa...TFTYGVEVRHPCFFDKGed
  87 GKLGAVHCQFAPWVRR.....EARGVARVRDCAAR.....Lrdag.GLVMAAEMRHASWFDSAaa
  88 DHLGCLLLQLPPSLTF.....DEAVAEAFFIGLRE.....Ry....SGAVVLEPRHASWAAAE..
  89 RMLGAVLVQLPPSF--.....NSNLQTELLDTICC.....En....EYRTAVEVRNKDLYSNEe.
  90 TRLGCLLLQLPPSAAF.....DAAVAARFFAMLRR.....Rw....DGGVVCEPRHASWFAAP..
  91 DTLGPLVWQFEQGHRL.....QADDLDAFLSLLPK.....Ragtr.ALRHVLEIRDHDAVDAS..
  92 GKLGAVHCQFAPWVRR.....EARGVARVRDCAAR.....Lrdag.GLVMAAEMRHASWFDSAaa
  93 DTLGPLVWQFEQGHRL.....QPDDLEGFLSLLPK.....Ragsr.VLRHVLEIRDHAAVDSA..
  94 EKLGPLLVQLPPSLSF.....ERDVVEDFFSLLHG.....Mt....LARTVCEPRHASWFTPE..
  95 ERFIAILFQFPESFRY.....TPENLEYIKRLSLD.....Fa....GIDRVIEVRHRSFANRE..
  96 SKLGTWLIQLPPKLAF.....DAKTFDSFFDLVNG.....Cs....DAMVAIEPRNATWFTEE..
  97 GRLGAVLFQFAPWITR.....APDGLALVDECRAR.....Ma....GYMMAAEFRNQSWFDEAha
  98 AKLGPINWQFLPTKAF.....DPEDFAAFLALLPP.....Ehegq.RLRHAVEVRHESFRDPA..
  99 GRLGTVLFQFPPWFAP.....GDPAEATLEACALR.....Tq....GWPLAVEFRHPGWWEPEra
 100 ERVSPLWLQLSAAF--.....TPQRLGELLYFLDE.....Ls....PRRIAVEVRHPAFFDKGed
 101 PRIGQYWLQLPATF--.....GPRELPALWHFLDS.....Lpg...EFNYGVEVRHPQFFAKGee
 102 EKRGPLLCQLPPSLAF.....ESRTFDIAFKTMRN.....Td....MGPIVIEARHKSWASLE..
 103 EKRGPLLCQLPPSLAF.....ESRTFDIAFKTMRN.....Td....MGPIVIEARHKSWASLE..
 104 DRIGQLWLQLPAAF--.....GPNELDRLWQFIDK.....Lpa...GFQYGVEVRHPEFFAKGaa
 105 DLIDFYLFQMPPSFKK.....TAENMSRIEKIALP.....L.....GERAAFEFRHPSWFTEG..
 106 -SPRFYLFQMPPTFKY.....NEENLKRVLEFEKI.....V.....GEKMAIEFRDTKWYEN-..
 107 EKTGLWKIQLPAHF--.....GPENLPALAQFLNQ.....Vpq...GLTYGVEVRHAAFFAKGea
 108 DCLANLFIQFPISFER.....TPANRYYLAELVSW.....Fq....EEVLAIEFRHPSWHNQS..
 109 HLIDFYLFQAPPRF--.....--EEIERALKFAEK.....Tgl...GERFALEIRNKELLGND..
 110 PRCGPLLFQLSPLAGM.....ADDGPAFLARLDAF.....La12tpNACYAVEIRDAALLTPR..
 111 RKAGVLVFQFSPLPDQllaq.PAELIDRLAAFFAA.....Lpp8adGTRYAIEIRDASLLTPR..
 112 -GARFILIQLPRSFKE.....NEESFSNAEKFFNS.....Ierk..DFEIAVELRG--WSEKG..
 113 ENLGMSFLQMHDNF--.....KPKDMDKLDAFLKK.....Fpa...SVPLAVELRNEEWYSDKnv
 114 HRIDFYLFQAPPKF--.....--DDAAKALGFAEE.....Tgl...GERFALEIRNKELLGNN..
 115 TRCGPLVFQLSPLGAL.....AEDAIGFLERLEAF.....La12tpDAVYAVELRDATLLTPR..
 116 HLIDFYLFQVPPKF--.....--DDVERALRFVEA.....Vkl...GKRFALEIRNKALLGND..
 117 KKAGVLVFQFSPMPDQ.....LLADPAALIERLAA.....Ff12pdGTRYAIEIRDACLLTPR..
 118 AKAGALVFQISPLPDQml7aaFIERLGEFLAALPK.....Lpd...GTCYAIEIRDASLLTPR..
 119 -NARFILIQLPRSFKE.....SEESFSNAERFFSI.....Idrg..EFEIAVELRG--WSERG..
 120 -NPDFYLFQLPPTFKR.....NSENEKRVFQFAEV.....L.....KDKMAVEFRDIQWYLK-..
 121 -GARFILIQLPRSFKE.....GEESFENAEKFFNA.....Idrg..DFEIGVELRG--WSEKG..
 122 AKCGPLLFQLSPLGSL.....ANDAAAFLDRLDGF.....Ls12tpHACYAVEMRDPVLLTPR..
 123 -KAEIIVFQTPKSFRD.....TAENMENMRAFFSS.....Idg...SFTFCFEPRG--WSEES..
 124 -KARIIVVQTPASFEA.....SIENSERIVEFFNK.....Aerg..GFIIAWEPRGAWWENPN..
 125 -RPEVLVFQTPPSLKP.....EPYIYDFFTAVMGK.....-.....-WRLAWEPRGETYGDLK..
 126 -NATIIIFQSPASFKP.....SEENTKAVIDYFST.....Lnk...SFKYAWEPRGEWYYRTDl.
 127 -NSRIIIFQTPPSFAP.....NNENIKNLKDFFSI.....Ldk...SFIYGWEPRGEWNQNHEv.
 128 EKLGMVFLQLHDNF--.....KPKDFDRLKKFIKD.....Wpv...EVPLAIELRNTEWFIDEnv
 129 GKLGYLHFGLPPWTEP.....KPRSFRYLERLAER.....Tq....GYLVAVEFRNPRWYTAWgf
 130 PRIGQYWLQLPATF--.....GPRELPALWHFLDS.....Lpg...EFNYGVEVRHPQFFAKGee
 131 ----------------.....--------------.....-.....-LPIAVEFRNASWFTDAvt


              160        170            180       190       200        
               |          |              |         |         |        
   1 ...TYEFLR.NHGI.TFVVVDEPKLP.....GLFPYRPITTTDYAYFRFHGRNERWF.....E..
   2 ...TYEFLR.NHGI.TFVVVDEPKLP.....GLFPYRPITTTDYAYFRFHGRNERWF.....E..
   3 dk.TLQFLE.QEKW.IHTICDEPQAGmg...SVPLVLEVTSAEMVLIRFHGRNVHGWldkg.E..
   4 dk.TLQFLE.QEKW.IHTICDEPQAGmg...SVPLVLEVTNAEMVLIRFHGRNVHGWldkg.E..
   5 dk.TLQFLE.QEKW.IHTICDEPQAGig...SVPLVLEVTNAEMVLIRFHGRNVHGWldkg.E..
   6 ek.TLDLLR.ELGF.IHTVVDEPQVGag...SVPIVLRETNSDMTLVRLHGRNQYGWmkassP..
   7 ...VYDLMR.KLKV.AWVIADSSRYP.....K----AKVVTADFAYIRMHGPEA---.....-..
   8 er.TLSYMR.EEGW.IHSICDEPQAGeg...SVPTVLVPSNEENVLVRFHGRNVEGWrrpqe-g.
   9 ek.TLDLLR.ELGF.IHTVVDEPQVGag...SVPIVLRETNSDMTLVRLHGRNQYGWmkansP..
  10 er.TLRFLA.EHQF.IHTICDEPQTEd....GSVPFVPVVTQETAFVRLHGRNVAGWlk8ssE..
  11 dr.TLQFLE.QEKW.IHTICDEPQAGig...SVPLVLEVTNSDMALIRFHGRNVHGWldkg.E..
  12 eq.TLSFMK.AEGW.IHSVCDEPQIGeg...SVPTVLRATDENKTLVRFHGRNKQGWmk6ggK..
  13 ek.TLDLLR.ELGF.IHTVVDEPQVGsg...SVPIVLRETNSEMTLVRLHGRNQYGWmkassP..
  14 ...ARCDLE.KSDL.HVVAVSSERIP.....-----LWIKEDSVVYVRLHGNVN---.....-..
  15 ek.TLELLR.ELGF.IHTVVDEPQVGsg...SVPIVLRETNSDMTLVRLHGRNQYGWmkassP..
  16 ...VFKILK.ERNV.TFCSVSAPNLP.....E----SLIETSETVYIRFHGKTS---.....-..
  17 ek.TLELLR.ELGF.IHTVVDEPQVGsg...SVPIVLRETNSDMTLVRLHGRNQYGWmkansP..
  18 eq.TISFMK.DGGW.MHSIADEPQAGkg...SVPFVPITTHPDTTIIRLHGRNFHGWtrsgnE..
  19 eq.TLSFLT.QHQI.IHAVVDEPQVKe....GSVPLVNRITSEIAFVRYHGRNHYGWtk7tdQ..
  20 ...VRDFLA.RNEL.AYTCVDEPDLP.....GLPGPVVYCTAPVAYVRFHGRNAAKWwr...H..
  21 ...CMKLLR.KHKV.GVVVADTAGKF.....---PYLEDVTADFVYLRLHGDAQ---.....-..
  22 ...VYRLLQ.EHGA.ALCVYDLGERS.....S----PRRLTAGFAYARLHGPEG---.....-..
  23 ...CMRLLR.RHNV.AVVVADTAGKF.....---PYLEDVSADFVYVRLHGDAQ---.....-..
  24 ...FIELLR.RYNI.ALVCADTPEWP.....----LLMDLTADFVYCRLHGAEQ---.....-..
  25 ...FVKLLR.KHRV.ALVVADSAGKW.....---PYVEDVTADFVYMRLHGDVE---.....-..
  26 ...FIELLR.EYRV.ALVVADTAGKW.....---PLLGDVCADFLYLRLHGDKE---.....-..
  27 ...FVRLLK.RYNT.ALVIADTAGKW.....---PYREDLTSDFVYLRLHGAEE---.....-..
  28 eq.TLAFLT.EHQI.IHAVVDEPQVKd....GSVPLVNRITNEIAFVRYHGRNHYGWtk7sdQ..
  29 ...FIKLLR.RNNV.ALVFAETAGKW.....---PYMEDVTSDFLYLRLHGDDS---.....-..
  30 eraLNQWLV.ENGI.DRIIMDSRPVFa16kkPKVPVHAIATASHPMIRFIGHPE---.....-..
  31 ermLNRLLL.DRGV.ERICLDSRALFn16kkPKVPPRPAALTSFPQVRFIGGPD---.....-..
  32 ...VYQLLE.TAGV.GLCLPVSPTVP.....----LDICLTAPWTYIRMHSGQW---.....-..
  33 ...VYALLE.RRRA.AYAVTSGLGLA.....----CIPRATTDLVYVRMHGPDP---.....-..
  34 ...LAELLR.ERGV.ALALVDRPGMP.....----RMEEATAGFVYIRWIGDRR---.....E..
  35 erlLNRHLR.ERGV.ERICLDSRALFs16kkPRLPIRPAAFSDTPQVRFIGGPD---.....-..
  36 sn.LTALLQ.KLGV.GRVLLDSRPIYt14rkPKLPLQLSVTAPFTLIRFISHPN---.....-..
  37 ermLNRLLL.DRGV.ERICLDSRALFs16kkPKVPPRPASLTLFPQVRFIGGPD---.....-..
  38 kq.MLQFMK.ENQF.SLVIVDEPQIPtn...PVPFYPYVTNPNLVLFRFHGRNAAGWland.A..
  39 ekaLNQWLI.EQNI.DRIIMDSRPVFs16kkPKVPVHAIATAKHPMIRFIGHPE---.....-..
  40 ektLNGLLV.EHQA.NRIIMDSRPVFa16kkPHVPVHAIATATQPMIRFIGHPE---.....-..
  41 ...FIALLR.EHNI.PVVYSEHATYP.....E----IADVTGDFVYARLQKGKD---.....-..
  42 sn.LTQLLE.SLGV.GRVLLDSRPIYt14rkPKLPLQFSVTAPFSLIRFISHPN---.....-..
  43 ...ILSSLV.DNGF.HIATVSSKDLP.....-----FLLIQDVIIYMRMHGDTN---.....-..
  44 ...FVKLIE.KYKV.AVVLAEHADYP.....----MIADVTGDFVYARLQKGSD---.....-..
  45 ...FAALAR.KYGA.AVCYAHHFTYP.....E----IADVTADFVYARLQRGED---.....-..
  46 sn.LTQLLE.TLGV.GRVLLDSRPIYt14rkPKLPLQFSVTAPFSLIRFISHPN---.....-..
  47 ...VFALLA.ERGV.GYCVMSGAHLP.....----CVLRVTAPFAYVRLHGPDH---.....-..
  48 eraLNRLLR.DRGV.ERLCLDSRPLFs16rkPRLPVRPAALTAFPQVRFIGHPL---.....-..
  49 ...FIDLIA.KYKV.AVVCADHHDYP.....----MLPDVTADFVYCRLQKGED---.....-..
  50 ...FIDLIA.KYKV.AVVCADHHDYP.....----MLPDVTADFVYCRLQKGED---.....-..
  51 ...VREGMG.EFGI.IWVSPDYPPVG.....GMPEPQVHVTGDVGYLRLHGRNRETWwe...G..
  52 erlLNRLLH.ERGV.ERICLDPRALFs16kkPKVPPRPAAFSQHPQVRFIGHPE---.....-..
  53 ...VYKVLQ.SKNI.VFCTSSYPGLP.....E----DFITTADTAYIRMHGNTE---.....-..
  54 ...VREVLE.ARGA.ALCWADVLSRP.....---ATPLWRTADWGYVRFHEGRA---.....-..
  55 ...ALAVLR.AHDV.ACVVAESAGRW.....---PTFEAVTTDLVHVRLHGDEE---.....-..
  56 erlLNRLLL.DRGV.ERICLDPRALFs16kkPRVPTRPAAFTQFPQVRFIGHPE---.....-..
  57 ...FVALIR.EFET.PVVFAEHGKYP.....A----IADVAGDFVYARLQKGND---.....-..
  58 ...VKRELM.RLGL.AHVSVDAPPHP.....EAPPRVLEPTREVAVLRCHGRNAETWkgp..-h.
  59 er.TRNFMS.RAAF.SLAIIDEPQLLnt...TIPFDPFVTNPNFALFRFHGRNAQGWqand.K..
  60 ...VVDSFI.EQGL.IWCSVDYPKVS.....GLPPSRLIFTQRTGYLRMHGNNLNWW.....Da.
  61 ...FVKLLR.RHAV.ALVVSDSTEPW.....---PQFEDLSADFVYMRLHGTET---.....-..
  62 ekrLNQWLM.ETKI.DRIIMDSRPVFa16kkPKVPVHAIATGEHPMIRFIGHPD---.....-..
  63 ...FVALAR.KYKV.AVVLAGDSDYP.....Q----IADITAPFVYARIMGTTD---.....-..
  64 qa.LNQLLQ.RYGC.GRVLLDTRPVYn14rkPQLPLHPDVIGEYALVRFISHPD---.....-..
  65 ...YLKLAR.KFKA.ATVFTDSPKFP.....S----FADLTSDFVYARLMNADE---.....-..
  66 ekrLNQWLM.ETKI.DRIIMDSRPVFa16kkPRVPVHAIATGEHPMIRFIGHPD---.....-..
  67 eqtLNRGLH.QRGV.NRVILDSRPVHa16kkPKVPVHAVLTAKNPLIRFIGSDD---.....-..
  68 ...FPAMLR.RHRA.ALVVSHAIADW.....---PYAEDVTSDFIYIRLHGAQA---.....-..
  69 ...TREVLV.ARRA.ALCWADVRARP.....---VTPLWRTTDWGYVRFHEGRA---.....-..
  70 eqtLNRGLH.QRGV.NRVILDSRPVHa16kkPKVPVHAVLTATNPLIRFIGSDD---.....-..
  71 ...KQAFAK.QPNL.IWCNVDYPTNI.....GLPSFYFYSNQKIAYLRLHGRNPNWW.....Ka.
  72 da.VFSFLK.DLGI.THVIVDEPHALnd...GVSFEPVVTNSKLALLRLHGRNQQGWsak..-ga
  73 eqtLNRGLH.QRGV.NQVILDSRPVHa16kkPKVPVHAVLTATNPLIRFIGSDD---.....-..
  74 ...YLKLAR.KYKA.ATVYTDSPKFP.....S----MADLSSDFVYARLMDSSE---.....-..
  75 ...INDI-I.NSGI.HVVSVSSKKMP.....-----FNLYDDKILYLRFHGDEN---.....-..
  76 ...FAALAR.KYKA.AIVYADHAKYP.....D----IADVTGDFVYARLQTGSD---.....-..
  77 ...VYGILR.KSGI.TMAWS----VL.....DYIKTPEIKTTENLYVRFLGNKSLEK.....K..
  78 sd.TLSYLE.RLKM.INVIVDEPFDGnq...GMPLVLQVTSAKKAMFRLHGRNAQGWftsg.K..
  79 ...AQALLH.RHRI.ARCAADPAPVPa....AALPDAPGMPGAPAYWRWHGTPK---.....-..
  80 earVNDLLR.DLQI.DKVTFDSRPLFq16rkPRTPVRQTVTAKRPMLRIVGRNR---.....-..
  81 ...TVELLA.AHRI.ALTLGDTPWIPtp...LALAWLDRLPTDWLYLRLMGSKSNGL.....-..
  82 snwTLALER.ELEL.VHTVVDSPQGFan...SVPPVWARTHPELALVRLHGRNAGAW.....Nnr
  83 ...FYDLCA.QYGV.AIVYAVDDEAP.....E-WPRIDQPTADFTYARLMCSRE---.....-..
  84 ...AETLLA.DRRI.ARVAADPAPVP.....A--AAMPGGWAGLAYFRWHGVPR---.....-..
  85 ...FREAIE.GLGV.AMVDVDSTERR.....---LNRIESGLKWAYVRLHGRNPGGW.....K..
  86 eqrLNRGLH.ARGV.NRVILDSRPVHa16kkPKVPVHAVVTASHPMVRFIGSDN---.....-..
  87 snwTLALER.ELEL.VHTVVDSPQGFan...SVPPVWARTHPELALVRLHGRNAGAW.....Nsr
  88 ...L--LLM.AYRI.AQAVVDPSRIS.....T--DAAPCGWRGVRYWRLHGSPR---.....-..
  89 ...LRKELE.KRGI.AIVDVDSTEHP.....---LSNLNSGLKWSYVRLHGRAQLGW.....K..
  90 ...AQALLA.RHRI.ARCAADPAPVP.....A--ASLPSPAAAPLYWRWHGAPR---.....-..
  91 ...LLALVR.GHGV.ATVFTDSDEHP.....S----FADLSTDFVYARLMRSQA---.....-..
  92 snwTLALER.ELEL.VHTVVDSPQGFan...SVPPVWARTHPELALVRLHGRNAGAW.....Nsr
  93 ...LIARVR.QHGV.ATVFTDSDEHP.....S----FADLSTDFVYARLMRSQA---.....-..
  94 ...VDALLR.DLNV.SRVAADPAKVP.....A--AAHPGGSLSMVYYRWHGSPK---.....-..
  95 ...FYEFVE.EVGFsTLVNVDAPKVK.....GLLIGPWVSVGTINYVRLHGRNKEKWha...H..
  96 ...VESRLI.ERRI.ARVAADPARVL.....G--SGEPGGWRGLAYFRWHGSPR---.....-..
  97 aw.SIDFLR.ERGI.VHVIVDAPPDVtn...RVHTVWEVTHPALAMVRLHGRNTETWsatg.-a.
  98 ...FVALAA.ERNV.AIVVEGDSEHP.....Q----IADPTADFVYARIMGTRE---.....-..
  99 ea.TRASLS.ALGA.SAVGTDMAQRLpg...SLPPIAPVTRPSLAVVRFHSRSAAWG.....R..
 100 erlLNRHLR.ERGV.ERICLDSRALFs16kkPRLPIRPAAFSDTPQVRFIGGPD---.....-..
 101 eqtLNRGLH.QRGV.NRVILDSRPVHa16kkPKVPVHAVLTATNPLIRFIGSDD---.....-..
 102 ...ASDLLK.TYEI.DRVLADPALVW.....P----VEVFDTPPRYIRLHGKPK---.....-..
 103 ...ASDLLK.TYEI.DRVLADPALVW.....P----VEVFDTPPRYIRLHGKPK---.....-..
 104 elaLNQGLH.QRSI.NRVMLDSRPIHa16kkPRLPVHAVVTGGQPLVRFIGGDQ---.....-..
 105 ...VVEWAE.GIGA.VLVSVDSPETS.....-----WIVSTRGVVYLRMHGRTF---.....-..
 106 ...---LPS.LTKA.TIVSIDSPIGT.....-----YIVNNSGVVYLRLHGREE---.....-..
 107 eraLNRLLM.DKQV.NRIIMDSRPLFa16kkPRVPVHAIATANTPVVRFIGQPD---.....-..
 108 ...VLDYFRgKEKL.IWCNVDYPQNI.....GLPAFQFYANQRTAYLRLHGRNPNWW.....Qa.
 109 ...ELCGRF.LNRV.TLVSVDSPDYI.....-----NRIFPGKTVYMRMHGREN---.....-..
 110 ...YIRMLR.ERGV.RFCLAARDRLPpv6qaAAQALMDDGAPGPLVLRWMLREGRSYsmae.Q..
 111 ...FIRALA.ALGV.RYCVGLHARMPdp6qaAALALLDGDAPGPLIVRWSLHGGFKY.....Eqa
 112 ...IKEFVR.EFDV.IDVTDPL----.....---VRIPLHKGKVRYYRLHGRYE---.....-..
 113 qddLHAMLV.KYKK.TFVLVDTAARR.....D--IMHMRLTSDKAFIRYVGANH---.....-..
 114 ...ELCAEL.LKKV.TLVSVDSPDYR.....-----NRIFPGKIVYMRMHGRDG---.....-..
 115 ...FIKMLR.AVGV.RYCVGLHERMPaa6qaAAVALLDAGAPGPLVVRWNLNSRYRYaqae.A..
 116 ...EACEEL.MKKV.TLVSVDSPDYK.....-----NRIFPGKNVYMRMHGRED---.....-..
 117 ...FIRTLA.ALGV.RYCVGLHARMPdp6qaAALALLDGDAPGPLIVRWSLHGGFKY.....Eqa
 118 ...FIRTLK.AAGV.RYCVGIHARMPdp6qaAALALLDGEPAGPLIVRWSLHGGFKY.....Eqa
 119 ...IKKFVR.EFDV.IDVVDPMVRVP.....-------LHGGGVNYYRLHGKYE---.....-..
 120 ...------.PLNV.TCVIVSIDSPI.....---GTYVIKNNDYIYLRLHGRDV---.....-..
 121 ...VKRFVR.EFDV.IDVTDPL----.....---LRIPLHKGSVNYYRLHGKYE---.....-..
 122 ...YIKLLR.RYGV.RFCLSARDRLPpv6qaSAQALMDAEAPGPLVLRWMLHAGRPYeva..-es
 123 ...VRAICE.ELDL.VHVVD------.....--PFVSKQLYGEICYYRLHGF-----.....-..
 124 ...LLAETA.RKAG.LVIAGDVLRGR.....-----LPPDEQELLYARLHGLGG---.....-..
 125 ...LIEKVA.ELGV.IIVVDPLRREP.....--------TAARHYYFRLHGLGG---.....-..
 126 ...LKKVLD.AVNI.IHVVD------.....---PFKHESLTSERYFRLHGIGK---.....-..
 127 ...LLKIFS.QIDV.IHVVDPFKNKS.....-------VDDKQIRYFRLHGLGS---.....-..
 128 fneTCELFE.QHNI.TNIIVDTAGRR.....D--MMHMRLTTPTAFVRYVG------.....-..
 129 ...VKRELM.RLGL.AHVSVDAPPHP.....EAPPRVLEPTREVAVLRCHGRNAETWkgp..-h.
 130 eqtLNRGLH.QRGV.NRV--------.....--------------------------.....-..
 131 ed.TLSYLQ.RLKM.INVTVDEPFDGnq...GMPFVLQVTSAKQAFFRLHGRNASGWfssg.K..


              210       220       230            240       250       26
               |         |         |              |         |         
   1 ..AEGEERYDYLYSEEELKTLFEDVVELSRRV.....KETYVFFNNCYKGQAAINALQFKKMLEE
   2 ..AEGEERYDYLYSEEELKTLFEDVVELSRRV.....KETYVFFNNCYKGQAAINALQFKKMLEE
   3 ..NWRAVRCLYRYNNKELEEWVERLEQLKKKT.....KDIYVLFNNNSGGDAADNAKQLMKMMN-
   4 ..NWRAVRCLYRYNNKELEEWVERLEQLKKKT.....KDIYVLFNNNSGGDAADNAKQLMKMMN-
   5 ..NWRAVRCLYRYNNKELEEWVERLEQLKKKT.....KNIYVLFNNNSGGDAADNAKQLMKMMN-
   6 ..EWREVRTLYRYNEEEINEWAKYVEHLQKLS.....KEVVVIFNNNSGGDAADNAKHLQKALQV
   7 ..-----LFSSSYSEEELEELAKDIEEYLKNC.....DEIYVYFNNDVNGCAIQNAKTLIK----
   8 ..NWREVRYLYRYSKDELAEWAEHLKQLAAQV.....KDVYVLFNNNSGGDAAANAKQMLELLEI
   9 ..EWREVRTLYRYNEEEINEWAKYVEHLQKLS.....KEVVVIFNNNSGGDAADNAKHLQKALQV
  10 ..DWRKVRCLYRYSEEELQELALHIRSLAEQA.....KDVYVFFNNNSAGDAVPNAKRLIEILGL
  11 ..NWRAVRCLYRYNNKELEEWVERLEQLKKKT.....KDIYVLFNNNSGGDAADNAKQLMKMMN-
  12 ..NWREVRYLYRYNQQELEDWKKHLNELQQQC.....KDVFVLFNNNSGGDAADNGKQMLELLDI
  13 ..EWREVRTLYRYNEEEINEWTKYVEHLQKLS.....KEVVVIFNNNSGGDAADNAKHLQKALQV
  14 ..-----GYATDYNEEYLTDLAQRIIDV--KP.....QSLYVYFNNDYSGYAPKNAIMLKSIIN-
  15 ..EWREVRTLYRYNEEEINEWAKYVEHLQKLS.....KEVVVIFNNNSGGDAADNAKHLQKALQV
  16 ..-----WYKYNYSERELKSWAKKIKKS--GA.....KEIFAYFNNDYNAYAPQNCLKLKELLG-
  17 ..EWREVRTLYRYNEEEINEWAKYVEHLQKLS.....KEVVVIFNNNSGGDAADNAKHLQKALQV
  18 ..NWREVRYLYDYNKEELLTLANEVTQLNKPN.....HDVIVLFNNNSGGHAANNAKQLQEMLGI
  19 ..EWRDVRYLYDYSDDELADLARKVEILNQKA.....KKVYVIFNNNSGGHAANNAKKYQNILDI
  20 ..EEAYERYDYLYTEAELKEWLPGIAYLAGQA.....RQVFVAFNNHYHSQAVTNARMLKELL--
  21 ..-----LYASGYSDHALDRWGERIAAWAAGGe17arRDVYCYFDNDMKVHAPFDARGLMQRLD-
  22 ..-----PYRGCYGERQLASWAGLLGGWAEEG.....TEVYCYFDNDEAGYAPRNAARLRQMM--
  23 ..-----LYASGYSDTALDRWAARIAAWAGGAe17amRDVYCYFDNDMKVHAPFDARGLMQRLQ-
  24 ..-----LYSSGYDDDALNCWSIRMDAWAKGHe18ggRDVYVYFDNDAKVHAPFDAANLAARLG-
  25 ..-----LYSSGYTARALRRWKERIQQWSEGRq18atRDVYCYFDNDQKVHAPYDARRLLQKLS-
  26 ..-----LYRSGYSEAALGQWQARIRAWAGGGq18taRDLYCYFDNDVKVRAPYDARRLLQLLE-
  27 ..-----LYASGYTRAALQRWAERIDAWHHGRq19ksREVFCYFDNDIKVRAPFDARSLLQRFD-
  28 ..EWRDVRYLYDYNEQELIDLAQKAQILAQKA.....KKVYVIFNNNSGGHAANNAKTYQRLLNI
  29 ..-----FYKKGYQPEQLRWWAQRLKIWAQGKs16stRDIFVFFDNDLKIKAPQDAEGLMLLL--
  30 ..--------EQKNYDFFVPWLSKLPQWIAEG.....KQPYVMIHTADNIIAPELAANIYKNLQ-
  31 ..--------LEANNEFLVQWVEKVAVWIEEG.....RTPYVFLHTPDNLKAPEQARRFHEQL--
  32 ..-------NVGYTDEELSTWVERIRSFLMQE.....IDVYVYFNNDPDGNAIRDAQRLYCLL--
  33 ..---AANYAGSYSDDDLRCWAERITAWDGDG.....KDVWMYFNNDLGGHAVRNALALREL---
  34 ..FPSHHTAPRRDRREDLRWWAERVRGFLEEG.....REVFAYANNHYQNHSPTTLRQFL-----
  35 ..--------LPANEVFLLPWVDKVADWIEAG.....LTPYVFLHTPDNHLAAQQAQRFHALLGQ
  36 ..--------LSVNQPFMEEWVRQIQQWLQAG.....VRIYFFVHCPIEARSPNIARHFQQLLE-
  37 ..--------LEANDQFLLQWVEKVAVWIEEG.....RTPYVFLHTPDNIRAAEQAMRFHQQL--
  38 ..EWRKKRTLYHYNTQEIADLSEAVLKMSQEA.....KEVGVIFNNNSGGDAAENALQMQKVLN-
  39 ..--------IEANLPFFGAWLHKLPEWIAQG.....KQPYLMIHTPDNDFAPQLAVQLYQQLQQ
  40 ..--------DLSNDPFFDNWLTRLPKWMADG.....KQPYLFIHTPDNVFAPELAIRLYQKLQQ
  41 ..-----DIATGYPQKSLSAWAKRLQLWADGGe17hkRDVFAYVIHEGKVRAPAAAMELIKL---
  42 ..--------LAVNQPFMEEWVQQIQQWLQAG.....TKIYFFVHCPIEERSPNTARHFQKLLE-
  43 ..-----GYATDYPLEKLKDMLNRIIDL--SP.....DYAYIYFNNDYNGYAPKNAEEIKSLL--
  44 ..-----EVKTCYPPKDLDRWAERLKTFAAGGe18apRDVFAFFITSGKVNAPNGARELQK----
  45 ..-----TIPTAYTPADLDAWADRAKIWAEGGm18rpRDVFVYFIHEGKIRAPHAARALMER---
  46 ..--------LAVNQVFMEEWVQQIQQWLQAG.....TRIYFFVHCPIEERSPNTARHFQKLLE-
  47 ..---DHLYAGSYSGADLAWWADRMLEWEAGG.....IEVHAYFNNDGGGNAVRDARGLIAALG-
  48 ..--------LAANDPFMAPWLDKVAAWIEEG.....RQPYVFLHTPDNLLAPELARRFHERLRE
  49 ..-----DIKTCYPQTGISDWAKRLKTYAAGGv18tqRDVFAFFITGGKINAPVGAQELQK----
  50 ..-----DIKTCYPQTGISDWAKRLKTYAAGGv18tqRDVFAFFITGGKINAPVGAQELQK----
  51 ..QSAGERHDYLYNRAEMDEWAEKIAAVAGDL.....SELYVFFQNTTGGHALKNIPMLREALN-
  52 ..--------LEANHTFLSPWVEKVAAWIEEG.....RNPYIFLHTSDNRLAAALAQRFHQRL--
  53 ..-----LYKSNYSDNQLQQLRNDLIDS--DV.....KEAFVYFDNTWGGNAIANAKTMEKLMQ-
  54 ..-----RRWPRYGRQALVTWARRIAETWPDD.....HEVYAYFNNDPHAAAVEDAAVF------
  55 ..-----LYSNRYSDAALDRWAEKVRGW-SEH.....ADVLVHFDNDAHGHAPHDALRLAARL--
  56 ..--------LEANDPFLVPWVAKIAEWIEEG.....RTPYIFLHTADNILAAKLAQRFHAQL--
  57 ..-----EIKTCYPPKQLDAWAQRFKDWAEGSe17epRDVFAYVIHEGKVRAPHGAMELI-----
  58 ..QKPYERFNWRYSEEELLDLAEATRTLAAQA.....ERVFVIFNNNYGTQGVEAALGLKRLLG-
  59 ..EWRKKRTLYRYSEKELQELAHEVKVVDSKT.....KEVGVIFNNNSGGDAAENALALQKILNI
  60 ..MSAADRHDYRYSKAEMNDWAQAIANQRQHF.....DTLYIFFQNTVNAHAYYNIAMLREALG-
  61 ..-----KYSGEYSDASLDRWAQRIETWSRGAq19haRAVYCYFDNDTKTRAPFDARRLMARLGV
  62 ..--------LESNLPFFAPWLSKLPLWITEG.....KQPYLMIHTPDNVEGPQLAKRLYQQLQQ
  63 ..-----KQAKGYSTKALDAWAERARQLAAGTt17aaRDVYLYVISGFKERNPAAAMALIK----
  64 ..--------RDRNPAYLAEWQERIRHWLAQG.....ITVYFFVHCPQEIYSPATAIAFQAQL--
  65 ..-----KVATGYAPKVLDQWAQRASAWAGGKs18kpKEAFLFFINGAKERAPAAAGALLERLG-
  66 ..--------LESNLPFFAPWLSKLPLWIAEG.....KQPYLMIHTPDNVEGPQLAKQLYQQLQQ
  67 ..--------MTQNRELFQVWLQKLAQW-HQT.....TTPYLFLHTPDIAQAPELVHTLWEDL--
  68 ..-----LYSGAYADKALDRWAQRVRAWAAGGe17vrRDVYCYFDNDQKVHAPFDAQRLRERL--
  69 ..-----AAWPHYGRRSLVTWIDRITAAWPHT.....SDVYTYFNNDPNTAAVQDAATF------
  70 ..--------MTQNRELFQVWLQKLAQW-HQT.....TTPYLFLHTPDIAQAPELVHTLWEDL--
  71 ..ETAQQRHDYRYSDPELQQLANLLHQHRSSF.....EQLYIYFQNTTNSHSFYNIATLKGYL--
  72 ..NWRSQRTLYRYSDQELAEFKQTVEQLQQQA.....DEVCVIFNNNSGGDAADNAMALKELLGV
  73 ..--------MTQNRELFQVWLQKLAQW-HQT.....TTPYLFLHTPDIAQAPELVHTLWEDL--
  74 ..-----KLTTGYGPKALDTWAEHARTWAAGKa17krREVFIFFINGAKERAPAAAQALLSRLGW
  75 ..-----GYMTDYSDR-LDYFAELILEN--NF.....DESYIYFNNDYNGLAPKNALRLIEIL--
  76 ..-----DNPDCYTPKGLDEWAARAKIWAEGKq18qpRDVFVYFITEGKVRAPFGAMALMKR---
  77 ..DLGEIRIN---RHGEIEQWVGKIKKQDSGQ.....GTVFIYANNHYEGLSPDTIKFIRHELG-
  78 ..EWRKERTNYRYSTDELTELAQWVKAVSERV.....EEVTIIFNNNGNHDAVDNAKELQKILGI
  79 ..-----VYYSGYDNAALQRLAAAVRSGMAAHaa...NEQWVIFDNTAAGLAVPNALQLQKLLG-
  80 ..--------VELAEAFLDQWVPIVVGWLAQG.....LRPIVFTHTPDDRLAPLFAELLLSKM--
  81 ..--EHFTHRQFDRTDTLDAWAAAVWRLAEGG.....KRVYVLLDNHFEGFSPGSATLLVRKLG-
  82 a.AASSSRFQYEYSPQELAELAERVRRLAERA.....RQTHAVFNTNYEDQGMRNAAGLAA----
  83 ..-----DEPTGMTSEELDGVVAQTHKW-AER.....GDVFAYFIAGAKVRNPAAAMALIGKL--
  84 ..-----VYYSDYDPESLDRIGRQVQAAAASG.....AEVWGIFDNTAAGHALGNALAI------
  85 ..AEN--PFDYRYTDAELREIASKIKSV--NY.....DDIFVYFNNHPHGSAPVNAMALSRMVG-
  86 ..--------MAQNREFFAAWLQKLPQW-RQT.....TTPFLFLHTPDIAQAPELVNTLWHDL--
  87 a.AASSSRFQYEYSPQELAELAERVRRLAERA.....RQTHAVFNTNYEDQGMRNAAGLAA----
  88 ..-----IYHSPYDSAYLETLAGDLQVAAVDG.....IDTWCIFDNTASGAALGNALELRRVL--
  89 ..SQN--PYDYRYSEQEISDLSSKIMAK--NY.....DEIFVYFNNHPRGSAPINALKMASCLG-
  90 ..-----RYYSSYAHTALQALAATVRASHPGStqpp.AERWVIFDNTAAGCATSNALELQRLL--
  91 ..-----RLTAGYPAPALARWAERIQAWRRGEd18qpREVFVFFISAAKERNPAAAMALLKEL--
  92 a.AASSSRFQYEYSPQELAELAERVRRLAERA.....RQTHAVFNTNYEDQGMRNAAGLAA----
  93 ..-----RLHTGYPAPALAQWAERIQAWRRGEd17taREVFVFFISAAKERNPAAAMALLQAL--
  94 ..-----MYSSSYLDSQLARLAAQVQA---NS.....GDVWVIFDNTAVGAAVENGLILRNLL--
  95 ..KEAYERYDYLYSIEELEEIKEKILRI-YEG.....KDTYVFFNNHYRGKGALNALQLKELFGE
  96 ..-----MYYSDYDRQALFSLGRRLESARLWG.....AETWCIFDNTAAGAALGNAL--------
  97 ..ASASDRFDYDYDEAELTELAVPIRAIATRA.....GRTHVIFNNCFEDQGQRNARTLMTIL--
  98 ..-----GEADGYPPEALDQWAARARDWEAGRa15tpRDVFLYVISGHKVANPAAAEALLA----
  99 ..GSKEDRFRYDYDVTELAAWVPRLRRAARQA.....DELHVLFNNCCADAAVGAAESMRRLL--
 100 ..--------LPANEVFLLPWVDKVADWIEAG.....LTPYVFLHTPDNHLAAQQAQRFHALLGQ
 101 ..--------MTQNRELFQVWLQKLAQW-HQT.....TTPYLFLHTPDIAQAPELVHTLWEDL--
 102 ..-----IYYSVYSDEEIEFFFKNVAP-----.....-DGWCVFDNTASGAAIENALSM------
 103 ..-----IYYSVYSDEEIEFFFKNVAP-----.....-DGWCVFDNTASGAAIENALSM------
 104 ..--------LDDNLALFAPWLQKLPLW-EQH.....HQPYVFIHTPDNGDSPQQAQKIWQKL--
 105 ..-----WYSHFYDEEELREVAGRILAL--GP.....KKVYVFFNN--NHAMLENARSMLALL--
 106 ..-----WYIYEYSEKELVELSNRIISL--KP.....KEIYVFFNN--DHWMLENARLMKKILEE
 107 ..------------------------------.....----------------------------
 108 ..QSAQERHDYRYNDTELQNLANLLNQYRNEF.....DQLYLYFQNTTKSHSFYNIEQLKAYL--
 109 ..-----WYSYNYSQEEIKETIEKITEL--ER.....EKVYIYFNN--NHKMLENARK-------
 110 ..AFSPFDKLVDEDAETRHAIADVVVRTLRAG.....QPAHVIVSNNAEGCAPLSIARLAEVI--
 111 kaKYEPFDKLVDEDPATRSALAELAARYALAG.....QPVIITINNKAEGSAPLSCIALAR----
 112 ..-EGKIIYNHSYSDEELKKLRERVLGW--NI.....EESFVFFNN---VAMCKDAKRFKSLL--
 113 ..---------ESDYARLDDWIKRIKTWRKEGl....NELYFFVHQNVELESPLLSAYFIEKMNK
 114 ..-----WYSYNYTQEEIKEIARKIDVF--EP.....EKVYIYFNN--NHNMLENARKAL-----
 115 ..AYKPFDKLVDEDPFSRETLADMAVAALAAG.....RQVTILVSNKAEGCSPLSCIRLAEAI--
 116 ..-----WYSYDYSQAEISETIRKIHEF--GP.....EKTYIYFNN--NHNMLDNARKA------
 117 kaKYEPFDQLVDEDPATRSALAELAARYALAG.....QPVIITINNKAEGSAPLSCIALAR----
 118 kaKYEPFNQLVDQDPATRASLAELAARYALAG.....QPVVIAINNKAEGSAPLSCVELAR----
 119 ..-NGRIIYSYKYSDEELLKIRERVLSF--HV.....EESYVYFNN---SNMCEDAQRFKQL---
 120 ..-----WYTYDYSEKELKELADKIISL--NP.....KYVYVFFNN--NHWMLDNGRYMLKIL--
 121 ..-GGKIIYNHSYSDEELKKIRERVLGW--NV.....EESFVFFNN---TSMCRDAKRFKLIL--
 122 ..IYAPFNRLVDEDPETRDAIADLVVRTLNAG.....QSATVIISNKAEGSAPLTCIRLAEAI--
 123 ..-----DYKHKYTDDELEKLLGIVDR-----.....-DGYVMFNN---VHMFDDALRFKKLVE-
 124 ..--GEVNYKYKYTDDDLKRLATTICGG--LW.....SEAYVMFNN---VYSFDDALRFKQVL--
 125 ..--REVNYKYKYTPQDLQKLASIIKRL--DG.....EEAYVMFNN---VYMYEDAVEFK-----
 126 ..--GEVNYSYKYTDDDLKKLKSMVRDG----.....--DYVLFNN---IYSFNDALRFKEIL--
 127 ..--SEVNYRYKYTKADLEKLKEYVLSE--RK.....ELIYVLFNN---VYSFDDALSFKRMI--
 128 ..------------------------------.....----------------------------
 129 ..QKPYERFNWRYSEEELLDLAEATRTLAAQA.....ERVFVIFNNNYGTQGVEAALGLKRLLG-
 130 ..------------------------------.....----------------------------
 131 ..NWRRERTNYRYSSAELKELAESIKAVAESV.....QDVMVIFNNNGNHDAVANAKELQELLGI


      0 
     | 
   1 RV
   2 R-
   3 --
   4 --
   5 --
   6 E-
   7 --
   8 E-
   9 E-
  10 --
  11 --
  12 E-
  13 E-
  14 --
  15 E-
  16 --
  17 E-
  18 D-
  19 --
  20 --
  21 --
  22 --
  23 --
  24 --
  25 --
  26 --
  27 --
  28 E-
  29 --
  30 --
  31 --
  32 --
  33 --
  34 --
  35 R-
  36 --
  37 --
  38 --
  39 --
  40 R-
  41 --
  42 --
  43 --
  44 --
  45 --
  46 --
  47 --
  48 --
  49 --
  50 --
  51 --
  52 --
  53 --
  54 --
  55 --
  56 --
  57 --
  58 --
  59 --
  60 --
  61 --
  62 Q-
  63 --
  64 --
  65 --
  66 Q-
  67 --
  68 --
  69 --
  70 --
  71 --
  72 S-
  73 --
  74 --
  75 --
  76 --
  77 --
  78 R-
  79 --
  80 --
  81 --
  82 --
  83 --
  84 --
  85 --
  86 --
  87 --
  88 --
  89 --
  90 --
  91 --
  92 --
  93 --
  94 --
  95 EV
  96 --
  97 --
  98 --
  99 --
 100 R-
 101 --
 102 --
 103 --
 104 --
 105 --
 106 K-
 107 --
 108 --
 109 --
 110 --
 111 --
 112 --
 113 E-
 114 --
 115 --
 116 --
 117 --
 118 --
 119 --
 120 --
 121 --
 122 --
 123 --
 124 --
 125 --
 126 --
 127 --
 128 --
 129 --
 130 --
 131 H-