(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html

Citations (SAM, SAM-T99, HMMs)

Sequence numbers correspond to the following labels:

    • T0208 EFR41, E.faecalis
    • gi|22992348|ref|ZP_00036998.1|_1:356 COG1312: D-mannonate dehydratase [Enterococcus faecium]
    • gi|46189412|ref|ZP_00206011.1|_1:352 COG1312: D-mannonate dehydratase [Enterococcus faecium]
    • gi|23026862|ref|ZP_00065335.1|_8:388 COG1312: D-mannonate dehydratase [Microbulbifer degradans 2-40]
    • gi|23029206|ref|ZP_00067563.1|_26:415 COG1312: D-mannonate dehydratase [Microbulbifer degradans 2-40]
    • gi|22405248|ref|ZP_00000149.1|_22:326 COG1312: D-mannonate dehydratase [Ferroplasma acidarmanus]
              10        20        30             40        50          
              |         |         |              |         |          
   1 MKWGFRWYGAAGDAIPLKHIRQIPGITGVVGTLLNKLPG.....DVWTVAEIQALKQSVE.....
   2 MKLVFRWYGEKHDTVTLEQIRQIPGVEGVVGALFDIPVG.....EVWPFEEIMKLKETVE.....
   3 MKLVFRWFGEKHDTVTLEQIRQIPGVEGVVGALFDIPVG.....EVWPLEEIMKLKETVE.....
   4 MEQTWRWYGP-NDPVSLADVRQA-GATGVVTALHHIPNG.....EVWSVEEILKRKAIIE.....
   5 MEQTWRWYGP-NDPVSLADVRQA-GATGVVTALHHIPNG.....EVWSVEEILKRKAIVE.....
   6 MEQTWRWYGP-NDPVSLADVRQA-GATGVVTALHHIPNG.....EVWSVEEILKRKAIVE.....
   7 MEQTWRWYGP-NDPVSLADVRQA-GATGVVTALHHIPNG.....EVWSVEEILKRKAIVE.....
   8 MEQTWRWYGP-NDPVSLADVRQA-GATGVVTALHHIPNG.....EVWSVEEILKRKAIVE.....
   9 MEQTWRWYGP-NDPVSLDDIRQA-GATGIVNALHHIPNG.....EVWSKEEILKRKAIIE.....
  10 MEQAWRWYGP-KDPVSLSDIRQA-GATGIVTALHHIPNG.....EVWSIEEIKKRKTEIE.....
  11 MEQTWRWYGP-NDPVSLADVRQA-GATGVVTALHHIPNG.....EVWSVEEILKRKAIVE.....
  12 MEQAWRWYGP-KDPVSLSDIRQA-GATGIVTALHHIPNG.....EIWSIEEIKKRKTEIE.....
  13 MEQTWRWYGP-NDPVSLDDICQA-GATGIVNALHHIPNG.....EVWSKEEILKRKAIIE.....
  14 MEQAWRWYGP-KDPVSLSDIRQA-GATGIVTALHHIPNG.....EIWGIEEIKKRKTEIE.....
  15 MEQTWRWYGP-NDPVSLDDICQA-GATGIVNALHHIPNG.....EVWSKEEILKRKAIIE.....
  16 MEQTWRWYGP-NDPVSLDDIRQA-GATGIVNALHHIPNG.....EVWSKEEILKRKAIIE.....
  17 MKQTWRWYGP-NDPVTLSDVRQA-GATGVVTALHHIPNG.....EIWSVDEIQKRKAIVE.....
  18 MEQTWRWYGP-NDPVSLNDIRQA-GATGIVNALHHIPNG.....EVWTKEEILIRKALIE.....
  19 MEQTWRWYGP-NDPVSLDDVRQA-GATGVVTALHHIPNG.....QVWSVEEINKRKALLE.....
  20 MEQTWRWYGP-NDPVSLDDVRQA-GATGVVTALHHIPNG.....QVWSVEEINKRKALLE.....
  21 MEQTWRWFGP-NDPVSLDDIRQA-GATGIVTALHHIPNG.....HIWNKDEILARKTLIE.....
  22 MEQTWRWYGP-NDPVSLDDIRQA-GATGVVTALHHIPNG.....VVWPVSEIKQRQAELA.....
  23 MRMVFRWFGAGNDSVSLAHIRQIPGVEGIVWALHDIPPG.....EVWPLSRIMEIKEQAE.....
  24 MKMTFRWFGKEHDTVSLDHIRQIPGVEGIVGALYHIPVG.....EVWPLDDILELKRQVN.....
  25 MKWGFRWYGAAGDAIPLKHIRQIPGITGVVGTLLNKLPG.....DVWTVAEIQALKQSVE.....
  26 MEMTFRWYGSQEEKITLDEIRQIPAVKGIVGTLMDIPVG.....EVWPRERIKELKEEIE.....
  27 MKWGFRWYGEKGDSIPLKYVRQIPGINGIIGTLLTKMPG.....DVWEISEIEELKASVE.....
  28 MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVG.....DVWEKEEIRAETEYIQ.....
  29 -EQTWRWYGP-NDPVSLWDIKQA-GATGIVNALHHIPNG.....EVWTVEEIMKRKQMIE.....
  30 MNITFRWYGQGNDTVTLEHVRQIPGVKGIVWALHQKPAG.....EVWEKEDIEAEVRFIQ.....
  31 MKMSFRWYGE-SDPVSLQYIRQIPGVTHIVSAIYDEPVG.....EVWPAHKIDALKATIE.....
  32 MEMTMRWFGSNADKIKLSEIAQVPGVKGVVGMIMDIPAG.....EIWPKERIKALKEEIE.....
  33 MQLSFRWYGD-SDPVTLKQIKQIPDMKHIVSAIYDVPVG.....DVWTKDKINALKSSIE.....
  34 MNLSFRWYGA-DDAVKLQYIRQIPSIKSIVTAIYDVPVG.....EKWSIEAILKLKNEVE.....
  35 MAQTMRWFGP-SDPVSLRDIRQA-GCTGVVSALHHLPNG.....AIWPLAEILERKQLIE.....
  36 MQETWRWFGP-NDSISLQKIAQA-GATGIVSSLHHVPTG.....ALWQLEEIEAQKKIIE.....
  37 MEQCWRWYGP-DDPVTLDHVRQA-GATGVVSALHHIYDG.....RAWPEADVLERKRIIE.....
  38 MEMTFRWYGK-DDPVKLEYIKQIPGMKGIVTAIYDIPVG.....EVWPLERILELKKEIE.....
  39 MRLTMRWFGP-SDKVKLEYIKQIPGMKGIVSAIYDVAVG.....GVWPKEKILALKNNIE.....
  40 MRHTWRWFGP-VDRVSVQDAAQA-GAHGIVSALHHIPTG.....DVWPVDEIGKRQEEVR.....
  41 MEKTWRWFGK-KDKITLPMLRQI-GVEGIVTALHDIPNG.....EIWTIEAINALKSYIE.....
  42 MRHTWRWFGP-VDKVTVQDAAQA-GAEGIVSALHHITTG.....DVWPVDEITKRHEAIK.....
  43 MKQTWRWFGP-RDTATIDDVVQA-GAEGIVTALHHLPNG.....AVWTRKEIVQRQAEISll6gs
  44 MKETWRWFGE-SDPITLEHVRQT-GASGVVTALHQIPDG.....TAWPAEEIAKRKAMIE.....
  45 MEMSFRWYGE-DDPVTLENIGQIPTMKGIVTAIYDVPVG.....EVWSRERIQQLKEKVE.....
  46 MEMSFRWYGE-DDPVTLENIGQIPTMKGIVTAIYDVPVG.....EVWSRERIQQLKEKVE.....
  47 MRQTWRWFGP-KDLVSVDDMRQA-GVEGVVSALHHIPTG.....ALWTPEEIARRQREIGvm6ga
  48 MLQGWRWYGP-DDPVSLDDVRQA-GATDIVSALHQVPIG.....EAWTRKAVEERKNFIErgqpg
  49 MRQAWRWFGP-EAGVPLDAVRQA-GATDIVSALHEVPIG.....QEWTSAQIVERKNLIEstptg
  50 MRQAWRWFGP-EAGVPLDAVRQA-GATDIVSALHEVPIG.....QEWTSAQIVERKNLIEstptg
  51 -----RWFAD----------------------WRNSYED.....DPWDYYPLMRYRNMIE.....
  52 ------------------ILKQI-GVNDAVGVLPRNYNDwr7edEPWDYYPLMKYMNMLQ.....
  53 -------------------LRNI-GINDAVGILPRHFSDwr7elNPWDYISLKRYKNMIN.....
  54 -------------------LKQI-GVNEVVGTLPRDPSDwr7pdLPWDYAPLSSLKRRLS.....
  55 ------------DDEDFKVWAQL-GVKNISADPPGKPAS.....--WVLDDFERLRDKVE.....
  56 -------------------MAQL-GVRHVCADLAGNPHD.....--WTLDDLLRHREKIE.....
  57 MEQTWRWYGP-NDPVSLADVRQA-GATGVVTALHHIPNG.....EVWSVEEILKRKAIVE.....
  58 ---------------------------------------.....----------------.....


         60            70            80        90       100       110  
         |             |             |         |         |         |  
   1 QEGLALLGIE....SVAIHD....AIKAGTDQRDHYIDNYRQTLRNLGKCGISLVCYSFKPIFGW
   2 KAGLKLEVIE....SVNVHE....DIKLGLPTRDRYIENYKKTIRNLAKAGVKVVCYNFMPVFDW
   3 RAGLKLEVIE....SVNVHE....DIKLGLPTRDRYIENYKETIRNLAKAGVKVVCYNFMPVFDW
   4 DAGLVWSVVE....SVPIHE....DIKTHTGNYEQWIANYQQTLRNLAQCGIRTVCYNFMPVLDW
   5 DAGLVWSVVE....SVPIHE....DIKTHTGNYEQWIANYQQTLRNLAQCGIRTVCYNFMPVLDW
   6 DAGLVWSVVE....SVPIHE....DIKTHTGNYEQWIANYQQTLRNLAQCGIRTVCYNFMPVLDW
   7 DAGLVWSVVE....SVPIHE....DIKTHTGNYEQWIANYQQTLRNLAQCGIRTVCYNFMPVLDW
   8 DAGLVWSVVE....SVPIHE....DIKTHTGNYEQWIANYQQTLRNLAQCGIRTVCYNFMPVLDW
   9 AKGLTWSVVE....SVPVHE....EIKTQTGNFQQWIDNYKQTLRNLAECGIDTVCYNFMPVLDW
  10 NAGLSWSVVE....SVPVHE....EIKTQTGNYQKWINNYKQTLRNLAQCGIDTVCYNFMPVLDW
  11 DAGLVWSVVE....SVPIHE....DIKTHTGNYEQWIANYQQTLRNLAQCGIRTVCYNFMPVLDW
  12 NAGLSWSVVE....SVPVHE....EIKTQTGNYQKWINNYKQTLRNLAQCGIDTVCYNFMPVLDW
  13 EKGLTWSVVE....SVPVHE....EIKTQTGNFQQWIDNYKQTLRNLAECGIDTVCYNFMPVLDW
  14 NAGLSWSVVE....SVPVHE....EIKTQTGNYQKWINNYKQTLRNLAQCGIDTVCYNFMPVLDW
  15 EKGLTWSVVE....SVPVHE....EIKTQTGNFQQWIDNYKQTLRNLAECGIDTVCYNFMPVLDW
  16 EKGLTWSVVE....SVPVHE....EIKTLTGNFQQWIDNYKQTLRNLAECGVDTVCYNFMPVLDW
  17 EAGLEWSVVE....SVPIHE....DIKTHTGQYDLWIKNYQQTLRNLAQCGIYTVCYNFMPVLDW
  18 DKGLTWSVVE....SVPVHE....EIKTQTGNYQLWIDNYKQTLRNLAECGIDTVCYNFMPVLDW
  19 EKGLVWSVVE....SVPIHE....DIKTQTGNYQQWIDNYKQTLRNLASCGIDIVCYNFMPVLDW
  20 EKGLVWSVVE....SVPIHE....DIKTQTGNYQQWIDNYKQTLRNLASCGIDIVCYNFMPVLDW
  21 NKGLIWSVVE....SVPVHE....EIKTRTGHYSQWINNYKTSLKNLAECGIDTVCYNFMPVLDW
  22 AKNLVWSVVE....SVPIHE....DIKTHSGNYQQYIENYQQTLRNIAECGIDTVCYNFMPILDW
  23 QHQFHIDVVE....SVNVHE....DIKLGLPTRDRYIEAYKQTIKHLAKAGVKVICYNFMPVFDW
  24 EKGFHLEVIE....SVNVHE....DIKLGLPSRDRYIENYKQTIRNLAKAGVKVICYNFMPIFDW
  25 QEGLALLGIE....SVAIHD....AIKAGTDQRDHYIDNYRQTLRNLGKCGISLVCYSFKPIFGW
  26 SRGLTLKVIE....SVNVHD....AIKIGLPSREQYIENYKQTIRNLAEYGIEVICYNFMPVFDW
  27 SQGLELLGIE....SVAIHD....AIKAGTDERDYYIDNYIRTIKNLSRCGVRLICYSFKPIFGW
  28 SYGFHAEVVE....SVNVHE....AIKLGNEERGRYIENYKQTIRNLAGFGVKVICYNFMPVFDW
  29 EVGLTWSVVE....SVPVHE....HIKTQTGEYLKYIENYKESIRNLAKCGVMVVTYNFMPVLDW
  30 SYGFHAEVVE....SVNVHE....AIKLGHEERGQYIEHYKQTIRNLSEFGVKVICYNFMPIFDW
  31 RAGLQFEVVE....SVPVHE....DIKLGKPGRDRLIDHYRQTIRHLGAAGVRVICYNFMPVFDW
  32 AAGLTLKVIE....SVNIHD....DIKIGLPTRDKYIENYKETIRNLAEFGIEVICYNFMPVFDW
  33 QEGLTLSVME....SLPVHE....SIKLGEANRDNLIENYKKSLRNLGESGIKTVCYNFMPVFDW
  34 SYGLNFDVIE....SVPVHE....DIKLGLKTRDKYIENYKENIRNLSKAGVKVICYNFMPIFDW
  35 KAGLEWKVVE....SVPVHE....HIKTQQAGFEELIENYKQTILNLGQAGIEVITYNFMPVLDW
  36 DAGLEWSVIE....SIPVHN....DIKTRTGNFQEYIENYKQSVINAGKAGVKTICYNFMPVVDW
  37 AAGLTWSVVE....SIPVHN....SFKIGAPERERYAGYYRDSIRTLATAGIKTICYNFMPVVDW
  38 SHGLKLSVIE....SVPVHE....DIKLGLPTRDRYIDNYIQTIRNLAEAGVDTICYNFMPVFDW
  39 RHGLTLDVIE....SVPVHE....DIKLGKPTRDRYIENYKQTLRHLAECGIDTVCYNFMPVFDW
  40 AGGLEWEVVE....SVPVSE....CIKTQTGPWREHVANWQETLRRLSAAGIRTVCYNFMPVLDW
  41 SYGLRWSVVE....SLPVCE....AIKYGGTEREQLIENYKVSLTNLGKCGIKTVCYNFMPVIDW
  42 AGGLYWDVVE....SVPVSE....DIKTQTGDWKNHIANWQETLRRLSASGIRTVCYNFMPVLDW
  43 PSGLRWDVVE....SLPVSE....EIKTQTGAWRSHVENYCASLENLWEAGIETICYNFMPILDW
  44 AAGLEWSVCE....SIPMEQ....SIKRGDADAPKAIARWKDTLSRLGRAGVPVVCYNFMPVVDW
  45 AAGLKISVIE....SVPVHE....DIKLGRPTRDLLIDNYIQTVKNLAAEGIDTICYNFMPVFDW
  46 AAGLKISVIE....SVPVHE....DIKLGRPTRDLLIDNYIQTVKNLAAEGIDTICYNFMPVFDW
  47 ASGLNWEVVE....SLPVSE....DIKKQKGDWRAHLETWKASMRNLRAAGIEVICYNFMPVLDW
  48 RSQLTWSVVE....SIPIPD....DVKRLGGKATKSIEAWIASLEAVAASGIKIICYNFMPVVDW
  49 RHPLTWSVVE....SIPVSD....DIKRSGKAARHDIGAWIASMEALARNDIKVICYNFMPVVDW
  50 RHPLTWSVVE....SIPVSD....DIKRSGKAARHDIGAWIASMEALARNDIKVICYNFMPVVDW
  51 DSGFHLTAIE....DNPPMQ....NIIYGTERRDEEIENVIRMIRNFGRIGVKVWCYNWMAGTGW
  52 DSGLNLIAIE....DNPPMN....GIMYGNSDREKEIDYISKMIENMGELNIKIWCYNWMAGSGW
  53 DSGFNLVAIE....DNPPMD....KIILNLDGKDDELENVARMIENFGKLNIKIWCYNWMAVIGW
  54 EYGLTLSAIE....DNPPME....KIKYGVKGKEDELENVLRLIENMGRLKIGVWCYNWMAGQGW
  55 SFGLVLDMVQlplpSRPIEQasypDILLAGPERDRQIDAVCTMIENIAKAGIPAAKYNLN-LIGI
  56 GFGLQLDMIQlplsSRPIEEqqspGILTAGPTRDREIDSICRLIENLARAGIPAAKYNFN-IIGI
  57 DAGLVWSVVE....SVPIHE....DIKTHTGNYEQWIANYQQTLRNLAQCGIRTVCYNFMPVLDW
  58 ----------....------....-----------------------------------------


           120       130       140            150       160          17
            |         |         |              |         |            
   1 AKTDLAYENEDGSLSLLFDQAVVENMQPEDMYQ.....LIHSQSKGFRLPGWEE...ERLQQFQE
   2 MRTDLHKKLPDGSETMEYDHRLIEGVTPDELIK.....RVKEGSQGFVLPGWEW...DRLEKLRE
   3 MRTDLHKKLPDGSETMEYDHSLIEGVTPDELIE.....RVKEGSEGFVLPGWEW...DRLEKLRE
   4 TRTDLEYVLPDGSKALRFDQIEFAAFEMHILKRp27dkARLTRNIIAGLPGAEEg..YTLDQFRK
   5 TRTDLEYVLPDGSKALRFDQIEFAAFEMHILKRp27dkARLTRNIIAGLPGAEEg..YTLDQFRK
   6 TRTDLEYVLPDGSKALRFDQIEFAAFEMHILKRp27dkARLTRNIIAGLPGAEEg..YTLDQFRK
   7 TRTDLEYVLPDGSKALRFDQIEFAAFEMHILKRp27dkARLTRNIIAGLPGAEEg..YTLDQFRK
   8 TRTDLEYVLPDGSKALRFDQIEFAAFEMHILKRp27dkARLTRNIIAGLPGAEEg..YTLDQFRK
   9 TRTDLEFEMPDGSKALRFDQIAFAAFELHILKRp27qiQQLTSNIIAGLPGAEEg..YTLEEFQA
  10 TRTDLAYELPDGSKALRFDHIAFAAFELHILKRp27diTQLTRNIIAGLPGAEEg..YTLDEFQT
  11 TRTDLEYVLPDGSKALRFDQIEFAAFEMHILKRp27dkARLTRNIIAGLPGAEEg..YTLDQFRK
  12 TRTDLAYELPDGSKALRFDHIAFAAFELHILKRp27diVQLTRNIIAGLPGAEEg..YTLDEFQT
  13 TRTDLEFEMPDGSKALRFDQIAFAAFELHILKRp27qiQQLTSNIIAGLPGAEEg..YTLEEFQA
  14 TRTDLAYELPDGSKALRFDHIAFAAFELHILKRp27diAQLTRNIIAGLPGAEEg..YTLDEFQT
  15 TRTDLEFEMPDGSKALRFDQIAFAAFELHILKRp27qiQQLTSNIIAGLPGAEEg..YTLEEFQA
  16 TRTDLEFEMPDGSKALRFDQIAFAAFELHILKRp27qiQQLTSNIIAGLPGAEEg..YTLEEFQA
  17 TRTDLEYVLPDGSKALRFDQIEFAAFELHILKRp27dkARLTRNIIAGLPGAEEg..YTLDQFRQ
  18 TRTDLEFEMDDGSKALRFDQIAFAAFELHILKRp27diAKLTGNIIAGLPGAEEg..YTLQEFQA
  19 TRTDLEYEMPDGSKALRFDQVAFAAFELYILKRp27diAKLTKNIIAGLPGSEEg..YTLEEFQA
  20 TRTDLEYEMPDGSKALRFDQVAFAAFELYILKRp27diAKLTKNIIAGLPGSEEg..YTLEEFQA
  21 TRTDLEYSLPDGSKALRFDQIAFAAFEIYILKRp27diKKLTTNIIAGLPGAEEg..YTLAEFQA
  22 TRTDLEYELPDGSKALRFDQIAFAAFELHILKRp27diAKLTGNIIAGLPGAEEg..YTLDQFRA
  23 VRTDLYKKLEDGSTALFYEKKEVDEMNPKGLVE.....TIAS-NKTFTMPGWEP...ERLASLKT
  24 TRSDLAKRRPDGSTVLAYEKQKIEQIDPEEMIR.....RIESGANGFLLPGWEP...ERLKTIKP
  25 AKTDLAYENEDGSLSLLFDQAVVENMQPEDMYQ.....LIHSQSKGFRLPGWEE...ERLQQFQE
  26 VKSDLDYRLEDGSSTLAFISDDIPDDPREIVAR.....IEHS-SNEFELPGWEP...ERLAHIKS
  27 AKTDLFNENNDGSYSLLYDQKIVDQMEPGEMYQ.....LIHSQSKGFKLPGWEE...ERLKKFAQ
  28 TRTDMFRPLEDGSTALFFEKAKVESLDPQELIR.....TVEEAS-DMTLPGWEP...EKLARIKE
  29 TRTDLAYTMPDGSKALRFEKAAFLAFDLFILKRp27dkKLLVRNMIAGLPGSEEs..FTVEQFQE
  30 TRTDMFRALEDGSTALFFEKAKVESLPPEELIR.....TVEES-SDLTLPGWEP...EKMARIKE
  31 TRTELSKTLDDGSTCLAFSTDAVDRIDPD----.....------DGIALPGWDSs..YQPEQLKA
  32 LKSDLDYRLADNSQTMAFVARDIPA-NPQEIID.....RVQAADGCFSLPGWEP...ERLSEVRG
  33 TRSNLDYELEDGSKTLMYDNDFVKDIDPV----.....-----TTNLNLPGWDEs..YTKEEMAT
  34 TRTQVDKVLDDGSTTLVYYKNQLKKMDPL----.....-----TGELSLPGWDSs..YTKDQLSS
  35 TRTNLDFELADGAKALKFERLALVAFDVYMLQRp27dkATLERNIIAGLPGSEEs..FTLAEFQQ
  36 TRTNLSYRLPNASQALRFEMTDFAAYDVYLLQRe27ekDLLEKNIIAGLPGGEGs..YTRDTIRE
  37 TRTDLMYRLPTTGYALRFDAVDFAAYDLFVLQRk27qvDQIERNLIAGLPATERk..YDRDSFRE
  38 TRSDLNYKLEDGSTCLIYDEEQVKKMDPAL---.....------GELELPGWDTs..YGEGGLKG
  39 TRSQLDFKLEDGSEALIYEEDVISRTNPL----.....-----SGELELPGWDTs..YENESLKG
  40 TRTDLRWTARHGAKAMRFDRIDFAAFDIHLLERp27rrLALSRNIGAGLPGSADg..YSLPQLRE
  41 IRTDLQYLCPDGTSSLYYDRIRFAYFDMKILERe32idTIIVKTQGFVNGNIKEgdkEPVVLFKR
  42 TRTDLRWETRHGARAMRFDLTDFAAFDIHILKRp27kiAALGRNIGAGLPGSADg..YTLAQLLE
  43 TRTDLRWRLPHGGRCMRFDLVDFAVFDVFLLKRa27srERLVQNATCGLPGANQt..LTINDVRE
  44 TRTNLRWQARNTGLALRFEMADFVAYDVFILKRi27eqSLLERNIIAGLPGGALv..QTRQSIAA
  45 TRTDLAYQYPDGSTALIFDETVSKKMDPV----.....-----NGELSLPGWDAs..YSKEEMKA
  46 TRTDLAYQYPDGSTALIFDETVSKKMDPV----.....-----NGELSLPGWDAs..YSKEEMKA
  47 TRTDLAWRRPSGATCMRFDLTDFAAFDIHILERp27rrSELARNVVFGLPGAAEq..FTLDDVRR
  48 CRTDLEWELPNGARAMRFDQDRFAAFELHILKRp27diDYLVMVIASALPGSTTep.MTIPQFRD
  49 CRTDLDYITSTGATAMRFDQDRFAAFDLHILQRk27eiEQLIVNIASALPGSTTep.LTIPAFRE
  50 CRTDLDYITSTGATAMRFDQDRFAAFDLHILRRk27eiEQLIVNIASALPGSTTep.LTIPAFRK
  51 SRTNTHIPGGYGSYVTGFDRSFIGD--------.....----------------...--------
  52 SRTKSDIIGKNGEYVSGFDYNDIKNIEPPVM--.....----------------...--------
  53 FRSSTHI-LKDYGTTSGFNENDINDYNFNV---.....----------------...--------
  54 MRSRISIPDRGGAEVTGFSLSDIEEYPPPKM--.....----------------...--------
  55 PRTEMEL-GRGGSLNEAWRWDKADH--------.....-----NADPGLAGV--...--------
  56 PRSNPEV-GRGGSLHSSFRWEKMDQ--------.....-----NAAPSIAGV--...--------
  57 TRTDLEYVLPDGSKALRF---------------.....----------------...--------
  58 ---------------------------------.....----------------...--------


      0       180       190       200       210           220       230
     |         |         |         |         |             |         |
   1 LKAMYAGVTEEDLVENLRYFLERVIPVCEEENIKMGIHPDDP..PWE.IF.GLPRITKNLADLKR
   2 TFELYKNVDEEKLFENLVYFLERVIPVCEECDVKLAIHPDDP..PWS.IF.GLPRIITNKENIER
   3 TFELYKNVDEEKLFENLVYFLERVIPVCEECDVKLAIHPDDP..PWS.IF.GLPRIITNKENIER
   4 HLELYKDIDKAKLRENFAVFLKAIIPVAEEVGVRMAVHPDDP..PRP.IL.GLPRIVSTIEDMQW
   5 HLELYKDIDKAKLRENFAVFLKAIIPVAEEVGVRMAVHPDDP..PRP.IL.GLPRIVSTIEDMQW
   6 HLELYKDIDKAKLRENFAVFLKAIIPVAEEVGVRMAVHPDDP..PRP.IL.GLPRIVSTIEDMQW
   7 HLELYKDIDKAKLRENFAVFLKAIIPVAEEVGVRMAVHPDDP..PRP.IL.GLPRIVSTIEDMQW
   8 HLELYKDIDKAKLRENFAVFLKAIIPVAEEVGVRMAVHPDDP..PRP.IL.GLPRIVSTIEDMQW
   9 QLDRYAGISKDKLREHMAYFLSQLMPVCEAHGLKLAVHPDDP..PRP.IL.GLPRIVSTIEDIDW
  10 QLDRYKDISPEKFRTHLAYFLNEIVPVAQEVGIKMAIHPDDP..PRP.IL.GLPRIVSTIEDMQW
  11 HLELYKDIDKAKLRENFAVFLKAIIPVAEEVGVRMAVHPDDP..PRP.IL.GLPRIVSTIEDMQW
  12 QLDRYKDISSEKFRTHLAYFLNEIVPVAQEVGIKMAIHPDDP..PRP.IL.GLPRIVSTIEDMQW
  13 QLDRYAGISKDKLREHMAYFLSQLMPVCEAHGLKLAVHPDDP..PRP.IL.GLPRIVSTIEDIDW
  14 QLDRYKDISSEKFRTHLAYFLNEIVPVAQEIGIKMAIHPDDP..PRP.IL.GLPRIVSTIEDMQW
  15 QLDRYAGISKDKLREHMAYFLSQLMPVCEAHGLKLAVHPDDP..PRP.IL.GLPRIVSTIEDIDW
  16 QLDRYAGISKDKLREHMAYFLSQLMPVCEAHGLKLAVHPDDP..PRP.IL.GLPRIVSTIEDIDW
  17 HLATYKDIDKAKLREHFAYFLKAIIPVADEVGVRMAVHPDDP..PRP.IL.GLPRIVSTIEDMQW
  18 QLDLYDGITKDKLREHMVYFLKELMPICDANGLKMAVHPDDP..PRP.IL.GLPRIVSTIEDIDW
  19 QLDRYKGISTEKFRTHLAYFLNEIVPVAQEVGIRMAIHPDDP..PRP.IL.GLPRIVSTIDDMQW
  20 QLDRYKGISTEKFRTHLAYFLNEIVPVAQEVGIRMAIHPDDP..PRP.IL.GLPRIVSTIDDMQW
  21 QLDRYKDITRDKLREHLAYFLHQIVPVCEEYGLRLAIHPDDP..PRP.IL.GLPRIISTIEDIEW
  22 RLAEYDGIDKAQLRENMAYFLRAIIPVAEQVGLRMAVHPDDP..PRP.IL.GLPRIVSTIEDMQW
  23 LFEAYEHVSTEDLWDHLHYFLQEVIPVAEACDIKMAIHPDDP..PWP.IF.GLPRIVTNHDNIRR
  24 LFSLYKGVTEEDLFDHLRYFLEQIVPVAEECGVRMALHPDDP..PWS.VF.GLPRIATNKENLDR
  25 LKAMYAGVTEEDLVENLRYFLERVIPVCEEENIKMGIHPDDP..PWE.IF.GLPRITKNLADLKR
  26 LLEAYASVDEEKLRENFAYFLQSIIPTCEEVGVKMAVHPDDP..PYS.IF.GLPRIVKNREDLDW
  27 LEKLYEGMTEEELFENLTYFLEKVIPVCEKADVKMAIHPDDP..PWE.LF.GFPRVTKNLGDLKK
  28 LFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDP..PWP.IF.GLPRIITGEASYKK
  29 ALDRYNDIDAEKLRSNLIFFLKEIAPVADEVGVKLVIHPDDP..PYT.IL.GLPRILSTEEDFKK
  30 LFEAYQTVEEKQLWANLEFFLHEILPVAEEHGIQMAIHPDDP..PWS.IF.GLPRIITGEKSYEK
  31 LLAEYRDVDEAALWANLEYFLKAIIPVAEEAGVKMAIHPDDP..PRP.IF.GLPRIVKNRDDLAR
  32 LFEAYKNVDEHKLRENFAYFLKAIIPTCEEVGIKMAVHPDDP..PYP.MF.GLPRVVKNREDLDW
  33 LIEKYRQFDEEDLWKNLEYFLNAVLPIAIEHDIDLTIHPDDP..PWS.IF.GIPRIIKTKESYQR
  34 LFEKYQNVDQEVLWSNLEYFLKQIIPVAEECDVKMAIHPDDP..PYN.IF.GLPRIITNEQNLDR
  35 ALDTYEGIDEAKLREHLIYFLSEVCPVADSAGVKMAIHPDDP..PCS.IL.GLPRIIKNRQDIIS
  36 AIQQFIDLGTEGFRNHMFEFLREIIPAAESVGVKMCIHPDDP..PFS.LF.GLPRVVSTADDARK
  37 ALAEYDGIGPKELRDNLAWFLREIIPVAEEEGVRMCIHPDDP..PFS.LY.GLPRVVSTAQDARF
  38 LLEQYKDIDEEILWSNLNYFIQRIMKVADKVRMKMAIHPDDP..PWG.IF.GLPRIITNFDNLKR
  39 VLQAYKKISEEDLWDHLTYFVQAIMPVADEVGIKMAIHPDDP..PWS.IF.GLPRIVTNKANLER
  40 HLRTYDGVSREKLQRHLVEFLAEVAPVAERTGINICAHPDDP..PWA.LL.GLPRILSNAEDYAF
  41 LLTLYKDINRDILRENMCHFLSAIMPVCEEYGVNMCVHPDDP..PFQ.VL.GLPRIVTNEEDIAW
  42 KLRSYHGINRGRLQQNLIDFLSEVTPVAEEVGINICAHGDDP..PWP.LL.GLPRILSTEADYAH
  43 LLGRYQQIGPDLLRRHLYDFLELVIPTAERLGLRLCCHPDDP..PFS.LL.GLPRIMSTEEDYAD
  44 LIASFDGIDSATMQGNLLAFLKEVVPVAEEVGVHLGIHPDDP..PFS.LF.GLPRVVSTPADIRA
  45 IMDAYAEIDEEKLWENLTYFIKRIIPEAEAVGVKMAIHPDDP..PYS.IF.GLPRIITGLEAIER
  46 IMDAYAEIDEEKLWENLTYFIKRIIPEAEAVGVKMAIHPDDP..PYS.IF.GLPRIITGLEAIER
  47 HLSDYAAMRPETLRRHLVDFLSEVAPLAEELGVRLCCHPDDP..PFP.LL.GLPRVMSTEADYAA
  48 RLETYRDITPRILRQHLAEFLERVTPVAEQLGVSLTLHPDDP..PRP.LF.GLPRIASSADDYQA
  49 KLETYASIDAAHLRRNLVEFLEAVTPVADSLGVKLTLHPDDP..PRS.LF.GLPRIASTEADYAA
  50 KLETYASIDAAHLRRNLVEFLEAVTPVADSLGVKLTLHPDDP..PRS.LF.GLPRIASTEADYAA
  51 DLPRMGRIDAASLWKNLKYFLDEVIPVAEENDVRLAMHPDDP..PLP.SFrGIDRIMNSIEAYQR
  52 -----GKIGKDELWKNLKYFLDNIIPVAEENDVKLAMHPDDP..PIE.NFrGIDRIMNSIESYDK
  53 ------RINKSDLWKNLNDFLDFIVPIAEDNDVKLAMHPDDP..PLD.NFsGIPRIMNSIESYDH
  54 -----GKIDAETLWKNLAWFLDNVIPVAEDSGVKIAMHPDDP..PLEeIR.GVSRIMNNVKAFDK
  55 -------LSEDENWERIDYFLERVVPVAASNKVRLACHPHDPytPPG.YK.GVTRVLGTIEGLKK
  56 -------VSESENWERIDYFLERVVPVAEENRIRLACHPHDPytPPG.YR.GVTRVLGTVEGLKK
  57 ------------------------------------------..---.--.--------------
  58 ---------------------EAVTPAAEARGVKLTLHPDDP..PRS.LF.GLPRIASTADDYAA


             240       250             260          270       280      
              |         |               |            |         |      
   1 ILSLVDSPANGITFCTGSLGAD...PTN...DLPTMIREIG...HRINFVHFRNVKYLGE...H.
   2 MLKAVDSPYNGITFCMGSLGAN...PEN...NIPEMIRYFGkm.GRIHFAHVRNLKFTGE...K.
   3 LLKAVDSPYNGITLCMGSLGAN...PEN...NIPEMIRYFGkm.GRIHFAHVRNLKFTGE...K.
   4 MVDTVNSMANGFTMCTGSYGVR...ADN...DLVDMIKQFG...PRIYFTHLRSTMREDNp..K.
   5 MVDTVNSMANGFTMCTGSYGVR...ADN...DLVDMIKQFG...PRIYFTHLRSTMREDNp..K.
   6 MVDTVNSMANGFTMCTGSYGVR...ADN...DLVDMIKQFG...PRIYFTHLRSTMREDNp..K.
   7 MVDTVNSMANGFTMCTGSYGVR...ADN...DLVDMIKQFG...PRIYFTHLRSTMREDNp..K.
   8 MVDTVNSMANGFTMCTGSYGVR...ADN...DLVDMIKQFG...PRIYFTHLRSTMREDNp..K.
   9 LTEKVPSKMNGLTMCTGSYGVR...GDN...DLVKMIKKHG...ERIYFTHLRSTKREES...Np
  10 FVETQPLPANGFTMCTGSYGVR...SDN...DLVKMTEQFA...DRIYFAHLRSTQREDNp..L.
  11 MVDTVNSMANGFSMCTGSYGVR...ADY...DLVDMIKQFG...PRIYFTHLRSTMREDNp..K.
  12 FVETQPLPANGFTMCTGSYGVR...SDN...DLVKMTEQFA...DRIYFAHLRSTQREGNp..L.
  13 LTEKVPSKMNGLTMCTGSYGVR...GDN...DLVKMIKKHG...ERIYFTHLRSTKREES...Np
  14 FVETQPLPANGFTMCTGSYGVR...SDN...DLVKMTEQFA...DRIYFAHLRSTQREGNp..L.
  15 LTEKVPSKMNGLTMCTGSYGVR...GDN...DLVKMIKKHG...ERIYFTHLRSTKREES...Np
  16 LTEKVPSKMNGLTMCTGSYGVR...GDN...DLVKMIKKHG...ERIYFTHLRSTKREES...Np
  17 MVETVNSMANGFTMCTGSYGVR...ADN...DLVDMIKQFG...PRIYFTHLRSTLREENp..K.
  18 LTAEVPSQMNGITMCTGSYGAR...GDN...DLVNMIRQHG...DRIYFTHLRSTQREDNq..L.
  19 FVDTQPLAANGFTFCTGSYGVL...AEN...DLVKMAEKFA...DRIYFVHLRSTQREENp..R.
  20 FVDTQPLAANGFTFCTGSYGVL...AEN...DLVKMAEKFA...DRIYFAHLRSTQREENp..R.
  21 LTTIEPSPANGITMCTGSYGVR...SDN...DLVEIIKHYG...NRIYFTHLRSTQREENs..K.
  22 LKETVDSIHNGFTMCTGSYGVR...ADN...DLVKMIETFG...DRIHFTHLRSTCREGNp..K.
  23 LLKLVDHPTNGITLCSGALGAD...PNN...QVPEMIREFA...DRIPFAHIRNIKRFDN...G.
  24 IVHMVNSPANGLTLCSGSLGAN...PAN...DVPDIFRHFLrm.GRVPFAHVRNVEIHAN...G.
  25 ILSLVDSPANGITFCTGSLGAD...PTN...DLPTMIREIG...HRINFVHFRNVKYLGE...H.
  26 LCRIVDSPYNGITLCTGSIAED...PEN...DVYGILAEFCqr.DRIPFAHVRNIKFLAN...R.
  27 ILNAVDSPYNGLTLCTGSLGAN...PEN...DLVEIIHEVG...SRIHFVHFRNVEFLGE...R.
  28 LRAISDSPSNCITLCTGSMGAN...PAN...DMVEIAKTYA...GIAPFSHIRNVKIYEN...G.
  29 LIEAVPNESNGLCLCTGSFGVR...ADN...DLAGMMERFG...DRVNFVHLRSTQRDEE...G.
  30 LREISDSPANCITLCTGSMGAD...PAN...DMVKITKHYA...GAAPFAHIRNVKICDN...G.
  31 IVRIVDTPANGLTLCSGSLGAG...PQN...DVEALVREFGam.GRIHFAHIRNVKVDAN...G.
  32 ICNVVDSPSNAITLCTGSIAED...PAN...NVYEIMAEFVkr.DRIPFAHVRNIKFLPS...Gk
  33 LIAINSSKNNGICFCTGSLGCL...EEN...DLPEIIKEFG...DHIHFVHMRNIKRLDN...H.
  34 FLKIVDSKYNGLTFCTGSLGCA...SFN...DVVKMVDKYSsq.GRIHFMHVRNVKLLFD...G.
  35 LTKAVPNPSNGLCFCAGSYGAS...VDN...DLPAMVEEFG...ERVNFLHLRNVIRDAA...G.
  36 LLNAVPSPSNGLTLCAGSYGAR...GDN...DLVGMAKEFG...DRIYFVHLRNVKREPD...G.
  37 ILNAVDSPANGLTFCTGSYGTR...ADN...DIVAMVKEFA...DRIHFVHLRNITIEED...G.
  38 FIDLYDSPYHGITLCTGSLGCT...KVN...DMVQMINYFGkerNRIHFAHLRNVKITGD...S.
  39 LLSLYDSPNHGITMCSGSLGAN...EAN...DLPEMIRHFGgq.GRIHFAHARNIKRTGP...R.
  40 MLREVDSPANGVTLCTGSLGAL...AAN...DLPAMTRQFA...SRIHFVHLRNVLREEV...Rt
  41 FLNAVDNPHNGLTFCAGSLSAG...EHN...DTRELAKKFA...KRTHFIHLRSTAAMPG...G.
  42 MLSQVDSRANGVTLCTGSLGAR...ADN...DLPFIAGRFA...DRIHFVHLRNVTRDTDtvpC.
  43 LMRQIDSPANGMTLCSGSLGAR...PDN...DLTGMMRRLG...DRVHFLHLRNVHRESG...Gi
  44 ILSAVESPNNGITLCTGSYGAR...SDN...DLVAMAKEFA...SRVNFAHLRNVTVEAD...G.
  45 FVKLYDSKSNGITLCVGSYASD...PQN...DVLEISRRAFel.DRVNFVHARNIKLGDG...K.
  46 FVKLYDSKSNGITLCVGSYASD...PQN...DVLEISRRAFel.DRVNFVHARNIKLGDG...K.
  47 VMEAVDLKANGITLCTGSLGAR...AEN...DLPGMMERLG...DRVHFLHLRNVTLERD...Gd
  48 LFDAVPSKANGICLCTGSLGVR...PEN...NLPEMAERFG...PRIAFAHLRATKREAD...Gl
  49 IFAAVPAQSNGMCFCTGSLGVR...ADN...DLPAIARRFA...SRIHFSHLRATTREGD...Gr
  50 IFAAVPAQSNGMCFCTGSLGVR...ADN...DLPAIARRFA...SRIHFSHLRATTREGD...Gr
  51 LIDLNRSEYNGITLCQGNFTLM...-TD...DLPSVIRRFH...DRIYFVHFRDVS-GNS...E.
  52 LLELNRSKYNGITLCQGNFTLM...TDN...-LPSAIRHFN...DRIFFVHFRDVN-GNK...Y.
  53 LIELNKSDYNGITMCQGNFTLM...ADN...-LPDVIKHFN...KKIFFVHFRDVL-GDR...H.
  54 LIEMKRSEYNTITLCQGNFTLM...-TE...DLPSAIRHFVrk.KAVSFVHFRDVK-GKK...D.
  55 FVQMRENPYHGLNFCQGSIGEM...LDNpreEIDDIIRWFGsr.DKIFNVHFRNIS-GGK...L.
  56 FVGMRESPYHGLNFCQGTVAEMlddPKN...EINDVIRWFGqr.GKIFNVHFRNIR-GGR...L.
  57 ----------------------...---...----------...----------------...-.
  58 LFDAVPSQASGMCYCTGSLGVR...ADN...DLPAIARRFA...PRIHFAHLRATTREGD...Gr


               290       300       310            320            330   
                |         |         |              |              |   
   1 ....RFEETAHPSVAGSLDMAELMQALVDVGYE.....GVIRPDHGRAIWDE.....KAMPGYGL
   2 ....SFYETAHPSFCGSHDLFEVMKAFHDIGYE.....GYIRPDHGRLIWGE.....KARPGYGL
   3 ....SFYETAHPSFCGSHDLFEVMKAFHDIGYE.....GYIRPDHGRLIWGE.....KARPGYGL
   4 ....TFHEAAH--LNGDVDMYEVVKAIVEEEHRrk9dlIPMRPDHGHQMLDDlkk..KTNPGYSA
   5 ....TFHEAAH--LNGDVDMYEVVKAIVEEEHRrk9dlIPMRPDHGHQMLDDlkk..KTNPGYSA
   6 ....TFHEAAH--LNGDVDMYKVVKAIVEEEHRrk9dlIPMRPDHGHQMLDDlkk..KTNPGYSA
   7 ....TFHEAAH--LNGDVDMYEVVKAIVEEEHRrk9dlIPMRPDHGHQMLDDlkk..KTNPGYSA
   8 ....TFHEAAH--LNGDVDMYEVVKAIVEEEHRrk9dlIPMRPDHGHQMLDDlkk..KTNPGYSA
   9 m...TFHEAAH--LDGDVDMYNVVMAILDEEQRra9rlIPMRPDHGHQMLDDlkk..KTNPGYSA
  10 ....TFHEAAH--LEGDVDMFNVVKALLNEEYRrl9rlIPMRPDHGHQMLDDlrk..KTNPGYSA
  11 ....TFHEAAH--LNGDVDMYEVVKAIVEEEHRrk9dlIPMRPDHGHQMLDDlkk..KTNPGYSA
  12 ....TFHEAAH--LEGDVDMFNVVKALLNEEYRrl9rlIPMRPDHGHQMLDDlrk..KTNPGYSA
  13 m...TFHEAAH--LDGDVDMYNVVMAILDEEQRra9rlIPMRPDHGHQMLDDlkk..KTNPGYSA
  14 ....TFHEAAH--LEGDVDMFNVVKALLNEEYRrl9rlIPMRPDHGHQILDDlrk..KTNPGYSA
  15 m...TFHEAAH--LDGDVDMYNVVMAILDEEQRra9rlIPMRPDHGHQMLDDlkk..KTNPGYSA
  16 m...TFHEAAH--LDGDVDMYNVVMAILDEEQRra9rlIPMRPDHGHQMLDDlkk..KTNPGYSA
  17 ....TFHEAAH--LHGDVDMYEVVKAIVEEEHRrk9dlIPMRPDHGHQMLDDlkk..KTNPGYSA
  18 ....SFHEAAH--LDGDVDMYNVVMEILKEEQRrd9rlIPMRPDHGHQMLDDlnk..KTNPGYSA
  19 ....SFHEADH--LAGDVNMFGVTKALLTEEYRrk9rlIPMRPDHGHQMLDDlkk..KTNPGYSA
  20 ....SFHEADH--LAGDVNMFGVTKALLTEEYRrk9rlIPMRPDHGHQMLDDlkk..KTNPGYSA
  21 ....TFHEATH--LAGDVDMYNVVMEILREEYRrk9rlIPMRPDHGHQIIDDlkk..QTNPGYSC
  22 ....TFHEGGH--LQGDVDMYSVVKAILTEEQRrq9rpIPMRPDHGHQMLDDlhk..KTNPGYSA
  23 ....DFVETSHREQDGSIDIVSIVKAYHEVGFT.....GYVRPDHGRHIWDE.....QCRPGYGL
  24 ....DFEETSHRSCDGSLNICEIMKALHEANFQ.....GYIRPDHGRMIWGE.....QARPGYGL
  25 ....RFEETAHPSVAGSLDMAELMQALVDVGYE.....GVIRPDHGRAIWDE.....KAMPGYGL
  26 ....DFYEAPHKSEYGSLDMYRILKTMYDNGFN.....EYIRPDHGRMIWNE.....TGRPGYGL
  27 ....KFKETAHPSTEGSLDMYHIMKALVQEGFD.....GPIRPDHGRTVWGE.....VAMPGYGL
  28 ....DFIETSHLTKDGSINIQGVMEELHKQDYE.....GYVRPDHGRHLWGE.....QCRPGYGL
  29 ....NFYEANH--LEGNVDMYNVMKSLILLQQRrkcs.IAMRPDHGHQMIDDlkk..KTNPGYSC
  30 ....DFTETSHLTSDGSIDITGVVKELHGQDYK.....GYVRPDHGRHIWGE.....QCRPGYGL
  31 ....DFEETAHLSSCGSLDIAAIVKAYHDTGFT.....GYVRPDHGRMIWGE.....TGKPGYGL
  32 k...DFYEAPHMSKYGSLDMYKIMKAMYDNGFD.....GYIRPDHGRMIWGE.....TGRPGYGL
  33 ....SFVESGHLSKYGSVDMKAVVRALKDINYK.....GTIRPDHGRMIWGE.....TGKAGYGL
  34 ....SFEESAHYSPCGSLDIVEIMKVLHKNKFD.....GYIRPDHGRMIWGE.....TGRPGYGL
  35 ....NFMEAAH--LDGDTDMYELVSAIRRVSIKrqvs.IPMRPDHGHQMMDDldk..KTNPGYSG
  36 ....SFYEADH--LDGDNDMVGLVNALLCEERRr10caIPMRPDHGHLMADElnlp.DVKPGYSY
  37 ....SFYEAEH--LEGGTDMAHVILALMQEEARr10wrIPMRPDHGHLLADDigkk.KINPGYSL
  38 ....SFNEVAHLSEAGSLDFYEIVKAYCDYDFA.....GPYRPDHGRMIWGE.....TGRPGYGL
  39 ....SFQESAHLSEAGSVNMVAMLKAYHDIGFT.....GPLRPDHGRMIWGE.....KGRPGYGL
  40 pc..SFYEDEH--LEGDTDMVAVIAELLQEEQRr10hqIPMRPDHGQEILDDlsr..GAQPGYPA
  41 ....NFIESSH--LAGRGHIIDLIRIFEKENPG.....LPMRIDHGRMMLGDedk..GYNPGYSF
  42 ....SFFEDEH--LEGGTDMVAVIAALITEEARr10htIPMRPDHGQEILDDltr..GAQPGYPA
  43 pa..SFHESAH--LDGDVDMVSLMAEVLREEARr10hsIPMRPDHGHDICDDlnr..SAQPGYAT
  44 ....SFFEDDH--LDGGADMIGVIEALLREERSta9tnIPMRPDHGHLLGDDitk..KTNPGYSY
  45 ....SFKESAHPSEYGSIDMYEVIKLCHEFGFE.....GAIRPDHGRMIWGE.....TGRPGYGL
  46 ....SFKESAHPSEYGSIDMYEVIKLCHEFGFE.....GAIRPDHGRMIWGE.....TGRPGYGL
  47 alrnSFFEDGH--LEGGTDMVAMIAAILAEERRr10isIPMRPDHGQDILDDlgr..KGQPGYPS
  48 ....SFYESDH--LDGDVDMVAVLKALLKENARrs6krIVFRPDHGHRMLDDlaatkRTNPGYTA
  49 ....TFHEAAH--LEGDVDMVGILRILLEEDRKrd6qtIIFRSDHGHRMMDDlek..KVTPGYPV
  50 ....TFHEAAH--LEGDVDMVGILRILLEEDRKrd6qtIIFRSDHGHRMMDDlek..KVTPGYPV
  51 ....KFVETLI--GRGKTDMAACMNAYIEVDYR.....WIMRIDHSPTFPGDh....ELIPGYSY
  52 ....NYQESLI--NEGRTDMAACMKAYNDINYN.....GIMRVDHTPTLEGDi....ELVPGYSY
  53 ....NFIETLI--GHGKTDLYKCMKAYNDINFD.....GIMRVDHVPTLYSDd....ASVPGYSY
  54 ....NFIESFI--DDGKTDTASCMSAYIEEGFD.....GIMRTDHTPTLYGDt....YKVPGYSI
  55 ....SFMETFP--DEGDMDMVRSLKLYHELGYR.....YMIMPDHVPTIAGR.....DPV----G
  56 ....SFMETFP--EDGDMDMWRALKVYAEVGYK.....YMLMPDHVPKVSGK.....DP----EA
  57 ....-----------------------------.....--------------.....--------
  58 ....TFHESAH--LDGDVDMVAVLRELVAEDRRrg6esIVFRSDHGHRMLDDlkkv.CYNPVTPG


          340       350       
           |         |       
   1 YDRAMGLTYIQGLYEATKAKQNRK
   2 YDRALGATYILGLWEAIDKMKK--
   3 YDRALGATYILGLWEAISKMK---
   4 IGRLKGLAEVRGVELAIQ------
   5 IGRLKGLAEVRGVELAIQ------
   6 IGRLKGLAEVRGVELAIQ------
   7 IGRLKGLAEVRGVELAIQ------
   8 IGRLKGLAEVRGVELAIQ------
   9 IGRLKGLAEVRGLEMALK------
  10 IGRLKGLAEFRGLEMALKK-----
  11 IGRLKGLAEVRGVELAIQ------
  12 IGRLKGLAEFRGLEMALKK-----
  13 IGRLKGLAEVRGLEMALK------
  14 IGRLKGLAEFRGLEMALKK-----
  15 IGRLKGLAEVRGLEMALK------
  16 IGRLKGLAEVRGLEMALK------
  17 IGRLKGLAEVRGVELAIQ------
  18 IGRLKGLAEVRGLEMALK------
  19 IGRLRGLAEFRGLELALKK-----
  20 IGRLRGLAEFRGLELALKK-----
  21 IGRLKGLAEIRGLELGLR------
  22 IGRLKGLAEVRGVELALKR-----
  23 YDRALGIMYLWGIWDSVQNG----
  24 YDRALGIMYLLGIWDSLENEKKK-
  25 YDRAMGLTYIQGLYEATKAKQ---
  26 YDRALGAVYLNGLWEAIEKGNK--
  27 YDRAMGLTYMQGLYEAISK-----
  28 YDRALGIMYLNGLWDAYEAMAK--
  29 LGRLRGLAELRGLEMGI-------
  30 YDRALGIMYLNGLWDAFSSH----
  31 YDRALGAVYLNGLWEALAKF----
  32 YDRALGASYLNGLWEALE------
  33 FDRALGATYINGLIEGVE------
  34 YDRALGAMYITGIWETLEKISK--
  35 IGRIKGLAEIRGLEIGI-------
  36 TGRMKGLAELRGVIHALEV-----
  37 IGRLKGLAELRGIMRAVE------
  38 YDRALGAVYINGLIEAIKK-----
  39 YDRALGATYLNGIWEAV-------
  40 IGRLKGLAELRGIERALS------
  41 YGRMLALAQVEGMMTVVDDEIK--
  42 IGRLKGLAELRGIERTL-------
  43 IGRLRGLAELRGVHRAL-------
  44 IGRMKGLGELRGVIRTIERQLR--
  45 YDRALGATYVSGLYEAV-------
  46 YDRALGATYLSGLYEAV-------
  47 IGRLKGLAELRGIMTALD------
  48 IGRLRGLAELRGAVRAI-------
  49 IGRMRGLAELRGIITALD------
  50 IGRMRGLAELRGIITALD------
  51 TGRIYSIGYVQGLFDSLSNH----
  52 SGRIYSIGYIKGLRDSI-------
  53 LNRLYAIGYINGLRDSIKNGS---
  54 LGRLHAIGYIQGLIDG--------
  55 VAFGFCYGYIAALIEALD------
  56 AGFAFCFGYIAALLQALED-----
  57 ------------------------
  58 FGRMRGFAELRGILHALD------