DNA damage repair proteins--non-homologous end joining

The following tables of genes were modified from Joel Huberman's DNA Repair Lectures, which explain the color coding and organization of the tables. Eventually each of the proteins should have a link to a page of detailed information.

Genes and proteins important for NHEJ
(Non-homologous end joining)

Yeast gene name Mammalian gene name Protein

?

XRCC4

Unknown function; interacts with DNA ligase IV

HDF2

XRCC5

Ku80

HDF1

XRCC6

Ku70; deficiency associated with elevated frequency of T-cell lymphoma

not present in yeast

XRCC7

DNA-PKcs

RAD50 RAD50 Stimulates MRE11 exonuclease
MRE11 MRE11 3' to 5' exonuclease
XRS2 NBS1 Interacts with Rad50, Mre11

This is a draft page with information about DNA-repair proteins. There is a lot more work to be done on these pages.
(icon needed) UCSC Center for Biomolecular Engineering slug icon to go to School of Engineering home page UCSC Engineering (icon needed) DNA repair main page
       

The Bioinformatics group at UCSC is supported in part by NSF grant BIR-9408579, NSF grant MIP-9488395, DOE grant DE-FG03-95ER62112, LACOR grant 4158U0015-3A-01, and by GANN and NSF graduate fellowships.

The DNA-repair pages are not currently funded, so development of them is very slow.

Questions about page content should be directed to

Kevin Karplus
Computer Engineering
University of California, Santa Cruz
Santa Cruz, CA 95064
USA
karplus@soe.ucsc.edu
(831) 459-4250