UCSC Engineering
Mismatch-repair proteins are those that recognize specific mismatching base combinations right after replication and remove the offending nucleotides. This includes proofreading by replicases, and the products of the "mutator" genes.
The following tables of genes were modified from Joel Huberman's DNA Repair Lectures, which explain the color coding and organization of the tables. Eventually each of the proteins should have a link to a page of detailed information.
| E. coli | S. cerevisiae | Function in S. cerevisiae (human homologs have similar functions) |
Human |
|---|---|---|---|
| MutS | MSH1 | DNA repair in mitochondria | ? |
| " | MSH2 | loop mismatch repair (with MSH3) single mismatch repair (with MSH6) |
MSH2 |
| " | MSH3 | loop mismatch repair (with MSH2) | MSH3 |
| " | MSH4 | meiosis (with MLH1) | MSH4 |
| " | MSH5 | meiosis (with MLH1) | MSH5 |
| " | MSH6 | single mismatch repair (with MSH2) | MSH6/GTBP |
| MutL | MLH1 | mismatch repair | MLH1 |
| " | PMS1 | mismatch repair (with MLH1) | PMS2 |
" |
MLH2 |
Not involved in mismatch repair | ? |
| " | MLH3 | mismatch repair (with MLH1) |
PMS1 |
| MutH | ? | ? | ? |
| uvrD | ? | ? | ? |
? |
Exonuclease 1 |
mismatch repair (5' to 3' polarity) | Exonuclease 1 |
? |
RAD27 |
Mismatch repair (Flap endonuclease) | DNase IV FEN-1 |
| (icon needed) UCSC Center for Biomolecular Engineering |
UCSC Engineering
|
(icon needed) DNA repair main page |
The Bioinformatics group at UCSC is supported in part by NSF grant BIR-9408579, NSF grant MIP-9488395, DOE grant DE-FG03-95ER62112, LACOR grant 4158U0015-3A-01, and by GANN and NSF graduate fellowships.
The DNA-repair pages are not currently funded, so development of them is very slow.
Questions about page content should be directed to
Kevin Karplus