|
Research
interests
I am interested in computational approaches for predicting how genes
function and discovering how their functions can be regulated and manipulated to
produce orchestrated cellular responses.
I am particularly interested in approaches that combine genome-wide
functional data across multiple organisms to identify mechanisms
of gene activity in stem cells and cancer, and to understand how these genetic networks evolve.
- Discovering pathways underlying carcinogenesis. Work with Norm Lee at George Washington University Medical Center.
- Discovering molecular pathways targeted by bioactive compounds. With Scott Lokey in Chemistry.
- Discovering molecular signatures for stem-cells. With Camilla Forsberg in BME.
- Developing algorithms to detect genetic interactions from high-throughput data. Work on C. elegans interactions with Peter Roy at the University of Toronto, V. cholerae networks with Fitnat Yildiz in Microbiology and Environmental Toxicology, and interactions underlying colon cancer invasiveness with Norm Lee at GW.
List Publications [link]
|
