We focus primarily on the application of systems and control theory to research problems in single-molecule instrumentation and biophysics.
The image depicts a biological nanopore and a captured protein-bound DNA complex under voltage control. In this simple configuration, feedback voltage control enables rapid single-molecule manipulation and measurement. This research involves several collaborators, including faculty, staff and students from Biomolecular Engineering, Computer Engineering and Applied Mathematics and Statistics. Funding sources for research involving biological and solid-state nanopores include NIH, NSF and the W.M. Keck Foundation. Recent press on NSF CAREER grant.
Recent News:
September, 2009 Newly funded NIH grant,
Award Number R21RR025347 from the National Center For Research Resources.
Project Title: "A Nanopore-based Instrument for Single Molecule Analysis of DNA-binding Proteins."
March, 2009 Collaborative Agreement between UCSC and New Zealand-based
nanotechnology company IZON Limited established. We are using the resizable nanopore instrument
qNano developed by IZON for colloidal particle analysis and quantization.
January, 2009
W.M. Keck Foundation awards $1.5 Million to UCSC team to establish
Center for Nanoscale Optofluidics: Official Press Release.
UCSC Faculty: Holger Schmidt (EE), Mark Akeson (BME), Dave Deamer (BME), Harry Noller (MCD Bio), Jin Zhang (Chem) and William Dunbar (CE).
January, 2009 Prof. Dunbar has been awarded an NSF CAREER Award, for his proposal
entitled
"Measurement, modeling and control of molecular motors above a nanopore."
© 2007 William B. Dunbar | Design by A. Viklund