We focus primarily on the application of systems and control theory to research problems in single-molecule instrumentation and biophysics.
The image depicts a biological nanopore and a captured protein-bound DNA complex under voltage control. In this simple configuration, feedback voltage control enables rapid single-molecule manipulation and measurement. This research involves several collaborators, including faculty, staff and students from Biomolecular Engineering, Computer Engineering and Applied Mathematics and Statistics.
Funding sources for research involving biological and solid-state nanopores
include NIH, NSF and the W.M. Keck Foundation.
February, 2011 Graduate student Daniel Garalde
is the lead author on recent paper published in
The Journal of Biological Chemistry.
Full Information: Daniel R. Garalde, Christopher A. Simon, Joseph M. Dahl, Hongyun Wang, Mark Akeson, and Kate R. Lieberman
DISTINCT COMPLEXES OF DNA POLYMERASE I (KLENOW FRAGMENT) FOR BASE AND SUGAR DISCRIMINATION DURING NUCLEOTIDE SUBSTRATE SELECTION
J. Biol. Chem. 2011 jbc.M111.218750.
March, 2011 New paper entitled Measuring single-molecule DNA hybridization by active control of DNA in a nanopore in The Biophysical Journal. Lead author and PhD graduate Brett Gyarfas now working in the Lindsay Lab at ASU's Biodesign Institute.
© 2007 William B. Dunbar | Design by A. Viklund